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Outcomes After Endovascular Thrombectomy With or Without Alteplase in Routine Clinical Practice. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-13 Eric E Smith,Charlotte Zerna,Nicole Solomon,Roland Matsouaka,Brian Mac Grory,Jeffrey L Saver,Michael D Hill,Gregg C Fonarow,Lee H Schwamm,Steven R Messé,Ying Xian
Importance The effectiveness and safety of intravenous alteplase given before or concurrently with endovascular thrombectomy (EVT) is uncertain. Randomized clinical trials suggest there is little difference in outcomes but with only modest precision and insufficient power to analyze uncommon outcomes including symptomatic intracranial hemorrhage (sICH). Objective To determine whether 8 prespecified
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Identification of Caveolae-Associated Protein 4 Autoantibodies as a Biomarker of Immune-Mediated Rippling Muscle Disease in Adults. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-13 Divyanshu Dubey,Grayson Beecher,M Bakri Hammami,Andrew M Knight,Teerin Liewluck,James Triplett,Abhigyan Datta,Surendra Dasari,Youwen Zhang,Matthew M Roforth,Calvin R Jerde,Stephen J Murphy,William J Litchy,Anthony Amato,Vanda A Lennon,Andrew McKeon,John R Mills,Sean J Pittock,Margherita Milone
Importance Immune-mediated rippling muscle disease (iRMD) is a rare myopathy characterized by wavelike muscle contractions (rippling) and percussion- or stretch-induced muscle mounding. A serological biomarker of this disease is lacking. Objective To describe a novel autoantibody biomarker of iRMD and report associated clinicopathological characteristics. Design, Setting, and Participants This retrospective
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Implications of the National Institutes of Health Stroke Scale Cookie Theft Picture-A Closer Look. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-13 Sharon N Poisson,Kelly L Block,Karen D Orjuela
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Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-13 Edmond Teng,Paul T Manser,Karen Pickthorn,Flavia Brunstein,Mira Blendstrup,Sandra Sanabria Bohorquez,Kristin R Wildsmith,Bali Toth,Michael Dolton,Vidya Ramakrishnan,Ashwini Bobbala,Sietske A M Sikkes,Michael Ward,Reina N Fuji,Geoffrey A Kerchner,
Importance Neurofibrillary tangles composed of aggregated tau protein are one of the neuropathological hallmarks of Alzheimer disease (AD) and correlate with clinical disease severity. Monoclonal antibodies targeting tau may have the potential to ameliorate AD progression by slowing or stopping the spread and/or accumulation of pathological tau. Objective To evaluate the safety and efficacy of the
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Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months: A Secondary Analysis of the RESCUEicp Randomized Clinical Trial. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-06 Angelos G Kolias,Hadie Adams,Ivan S Timofeev,Elizabeth A Corteen,Iftakher Hossain,Marek Czosnyka,Jake Timothy,Ian Anderson,Diederik O Bulters,Antonio Belli,C Andrew Eynon,John Wadley,A David Mendelow,Patrick M Mitchell,Mark H Wilson,Giles Critchley,Juan Sahuquillo,Andreas Unterberg,Jussi P Posti,Franco Servadei,Graham M Teasdale,John D Pickard,David K Menon,Gordon D Murray,Peter J Kirkpatrick,Peter
Importance Trials often assess primary outcomes of traumatic brain injury at 6 months. Longer-term data are needed to assess outcomes for patients receiving surgical vs medical treatment for traumatic intracranial hypertension. Objective To evaluate 24-month outcomes for patients with traumatic intracranial hypertension treated with decompressive craniectomy or standard medical care. Design, Setting
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Disclosing Alzheimer Disease Biomarker Results to Research Participants. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-06 Joshua D Grill,Jason Karlawish
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Bilateral Complete Ophthalmoplegia in a 50-Year-Old Man. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-06 Nitika Arora,Jacqueline Leavitt,John J Chen
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Association of Aortic Stiffness and Pressure Pulsatility With Global Amyloid-β and Regional Tau Burden Among Framingham Heart Study Participants Without Dementia. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-06 Leroy L Cooper,Adrienne O'Donnell,Alexa S Beiser,Emma G Thibault,Justin S Sanchez,Emelia J Benjamin,Naomi M Hamburg,Ramachandran S Vasan,Martin G Larson,Keith A Johnson,Gary F Mitchell,Sudha Seshadri
Importance Aortic stiffness is associated with clinical hallmarks of Alzheimer disease and related dementias and could be a modifiable target for disease prevention. Objective To assess associations of aortic stiffness and pressure pulsatility with global amyloid-β plaques and regional tau burden in the brain of middle-aged and older adults without dementia. Design, Setting, and Participants The sample
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Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-31 Marte-Helene Bjørk,Helga Zoega,Maarit K Leinonen,Jacqueline M Cohen,Julie Werenberg Dreier,Kari Furu,Nils Erik Gilhus,Mika Gissler,Óskar Hálfdánarson,Jannicke Igland,Yuelian Sun,Torbjörn Tomson,Silje Alvestad,Jakob Christensen
Importance Women with epilepsy frequently need antiseizure medication (ASM) to prevent seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure to AMSs is uncertain. Objective To determine whether children exposed prenatally to ASMs in monotherapy and duotherapy have increased risk of neurodevelopmental disorders. Design, Setting, and Participants The Nordic register-based
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Rare APOE Missense Variants-Can We Overcome APOE ε4 and Alzheimer Disease Risk? JAMA Neurol. (IF 18.302) Pub Date : 2022-05-31 Gil D Rabinovici,Dena B Dubal
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Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-31 Yann Le Guen,Michael E Belloy,Benjamin Grenier-Boley,Itziar de Rojas,Atahualpa Castillo-Morales,Iris Jansen,Aude Nicolas,Céline Bellenguez,Carolina Dalmasso,Fahri Küçükali,Sarah J Eger,Katrine Laura Rasmussen,Jesper Qvist Thomassen,Jean-François Deleuze,Zihuai He,Valerio Napolioni,Philippe Amouyel,Frank Jessen,Patrick G Kehoe,Cornelia van Duijn,Magda Tsolaki,Pascual Sánchez-Juan,Kristel Sleegers,Martin
Importance The APOE ε2 and APOE ε4 alleles are the strongest protective and risk-increasing, respectively, genetic variants for late-onset Alzheimer disease (AD). However, the mechanisms linking APOE to AD-particularly the apoE protein's role in AD pathogenesis and how this is affected by APOE variants-remain poorly understood. Identifying missense variants in addition to APOE ε2 and APOE ε4 could
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Clinical Manifestations of Early-Onset Dementia With Lewy Bodies Compared With Late-Onset Dementia With Lewy Bodies and Early-Onset Alzheimer Disease. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-23 Jingwei Sim,Huihua Li,Shahul Hameed,Simon Kang Seng Ting
Importance Early-onset dementia, presenting in individuals younger than 65 years, is a diagnosis with significant social and financial implications. The early-onset form of dementia with Lewy bodies (DLB) is poorly understood. Objective To investigate clinical features that distinguish early-onset DLB (onset and diagnosis at age <65 years) from late-onset DLB (onset at age ≥65 years) and from early-onset
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TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-23 Takashi Kurashige,Hiroyuki Morino,Tomomi Murao,Yuishin Izumi,Tomohito Sugiura,Kazuya Kuraoka,Hideshi Kawakami,Tsuyoshi Torii,Hirofumi Maruyama
Importance Degeneration of neuromuscular junctions and axons is considered an important aspect of the pathomechanism of amyotrophic lateral sclerosis (ALS). However, a mechanism including the role of transactive response DNA-binding protein 43 (TDP-43) in axons has not been pathologically clarified. Objective To identify and characterize the histopathology of peripheral axons in the skeletal muscle
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Pneumorrhachis From Esophageal Perforation Due to Cervical Osteophyte. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-23 Stuart J McCarter,Benjamin A Johnson-Tesch
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Neuronal Ceroid Lipofuscinosis Owing to Complete Maternal Uniparental Disomy. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-16 Wenfei Yu,Lili Cao,Pengfei Lin
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Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-16 Alessandro Cagol,Sabine Schaedelin,Muhamed Barakovic,Pascal Benkert,Ramona-Alexandra Todea,Reza Rahmanzadeh,Riccardo Galbusera,Po-Jui Lu,Matthias Weigel,Lester Melie-Garcia,Esther Ruberte,Nina Siebenborn,Marco Battaglini,Ernst-Wilhelm Radue,Özgür Yaldizli,Johanna Oechtering,Tim Sinnecker,Johannes Lorscheider,Bettina Fischer-Barnicol,Stefanie Müller,Lutz Achtnichts,Jochen Vehoff,Giulio Disanto,Oliver
Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood. Objective To determine whether disability progression independent of relapse activity (PIRA) in patients with RMS is associated with accelerated brain tissue loss. Design, Setting, and Participants In this observational, longitudinal cohort study with median (IQR)
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Progressive Parkinsonism With Features of Mitochondrial Disease. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Tjerk J Lagrand,Mehri Salari,Alexander C Lehn
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Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Michael S Rafii,Olivier Sol,William C Mobley,Saskia Delpretti,Brian G Skotko,Anna D Burke,Marwan N Sabbagh,Shauna H Yuan,Robert A Rissman,Margaret Pulsifer,Casey Evans,A Carol Evans,Gregory Beth,Nicolas Fournier,Julian A Gray,Antonio Melo Dos Santos,Valerie Hliva,Marija Vukicevic,Marie Kosco-Vilbois,Johannes Streffer,Andrea Pfeifer,Howard H Feldman
Importance Individuals with Down syndrome (DS) are at high risk of developing Alzheimer disease due to an increased dose of the amyloid precursor protein gene, APP, which leads to increased levels of full-length APP and its products, including amyloid-β (Aβ). The liposome-based antiamyloid ACI-24 vaccine is intended to treat neurological disorders caused by misfolded Aβ pathological protein. However
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Risk Factors Associated With Alzheimer Disease and Related Dementias by Sex and Race and Ethnicity in the US. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Roch A Nianogo,Amy Rosenwohl-Mack,Kristine Yaffe,Anna Carrasco,Coles M Hoffmann,Deborah E Barnes
Importance Previous estimates suggested that 1 in 3 cases of Alzheimer disease and related dementia (ADRDs) in the US are associated with modifiable risk factors, the most prominent being physical inactivity, depression, and smoking. However, these estimates do not account for changes in risk factor prevalence over the past decade and do not consider potential differences by sex or race and ethnicity
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Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Ryosuke Oki,Yuishin Izumi,Koji Fujita,Ryosuke Miyamoto,Hiroyuki Nodera,Yasutaka Sato,Satoshi Sakaguchi,Hiroshi Nokihara,Kazuaki Kanai,Taiji Tsunemi,Nobutaka Hattori,Yuki Hatanaka,Masahiro Sonoo,Naoki Atsuta,Gen Sobue,Toshio Shimizu,Kazumoto Shibuya,Ken Ikeda,Osamu Kano,Kazuto Nishinaka,Yasuhiro Kojima,Masaya Oda,Kiyonobu Komai,Hitoshi Kikuchi,Nobuo Kohara,Makoto Urushitani,Yoshiaki Nakayama,Hidefumi
Importance The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there is a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin to be a promising agent. Objective To validate the efficacy and safety of ultrahigh-dose methylcobalamin for patients with ALS enrolled within 1 year of onset. Design, Setting, and Participants
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Cerebral Ultrasonography of Cytotoxic Edema in a Newborn With a Mitochondrial Disorder. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-09 Marta Agüera,Nuria Carreras,Thais Agut
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Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Kelly G Knupp,Ingrid E Scheffer,Berten Ceulemans,Joseph E Sullivan,Katherine C Nickels,Lieven Lagae,Renzo Guerrini,Sameer M Zuberi,Rima Nabbout,Kate Riney,Svetlana Shore,Anupam Agarwal,Michael Lock,Gail M Farfel,Bradley S Galer,Arnold R Gammaitoni,Ronald Davis,Antonio Gil-Nagel
Importance New treatment options are needed for patients with Lennox-Gastaut syndrome (LGS), a profoundly impairing, treatment-resistant, developmental and epileptic encephalopathy. Objective To evaluate the efficacy and safety of fenfluramine in patients with LGS. Design, Setting, and Participants This multicenter, double-blind, placebo-controlled, parallel-group randomized clinical trial was conducted
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Noninvasive Detection of Hippocampal Epileptiform Activity on Scalp Electroencephalogram. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Maurice Abou Jaoude,Claire S Jacobs,Rani A Sarkis,Jin Jing,Kyle R Pellerin,Andrew J Cole,Sydney S Cash,M Brandon Westover,Alice D Lam
Importance The hippocampus is a highly epileptogenic brain region, yet over 90% of hippocampal epileptiform activity (HEA) cannot be identified on scalp electroencephalogram (EEG) by human experts. Currently, detection of HEA requires intracranial electrodes, which limits our understanding of the role of HEA in brain diseases. Objective To develop and validate a machine learning algorithm that accurately
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When a Neurologist Gets a Cerebrospinal Fluid Leak. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-02 Liza Smirnoff
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Addition of Vision Impairment to a Life-Course Model of Potentially Modifiable Dementia Risk Factors in the US. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Joshua R Ehrlich,Jenna Goldstein,Bonnie K Swenor,Heather Whitson,Kenneth M Langa,Phillip Veliz
Importance Dementia prevention is a high priority, given the large impact of dementia on the well-being of individuals and society. The number of older adults with dementia in the US and globally is projected to increase as a result of population aging and growth. Thus, it is vital to identify potentially modifiable dementia risk factors. Vision impairment has been identified as a risk factor for accelerated
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Large Collaborative Registries and Real-world Data to Manage Amyloid-Related Imaging Abnormalities. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Fabrizio Piazza,Lutz Frölich,Alessandro Padovani
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Visual Impairment as a Modifiable Risk Factor in Dementia Prevention and Management. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Jennifer Deal,Julio C Rojas
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Large Collaborative Registries and Real-world Data to Manage Amyloid-Related Imaging Abnormalities-Reply. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Jacob N Hall,Sharon J Sha
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Adverse Childhood Experiences, Toxic Stress, and Trauma-Informed Neurology. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Robin Ortiz,Rachel Gilgoff,Nadine Burke Harris
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Photon-Counting Computed Tomography Scan of a Cerebrospinal Fluid Venous Fistula. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Fides R Schwartz,Michael D Malinzak,Timothy J Amrhein
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Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Christina B Young,Joseph R Winer,Kyan Younes,Karly A Cody,Tobey J Betthauser,Sterling C Johnson,Aaron Schultz,Reisa A Sperling,Michael D Greicius,Inma Cobos,Kathleen L Poston,Elizabeth C Mormino,
Importance Characterization of early tau deposition in individuals with preclinical Alzheimer disease (AD) is critical for prevention trials that aim to select individuals at risk for AD and halt the progression of disease. Objective To evaluate the prevalence of cortical tau positron emission tomography (PET) heterogeneity in a large cohort of clinically unimpaired older adults with elevated β-amyloid
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Blood Biomarkers May Have Found a New Frontier in Spaceflight-Reply. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Peter Zu Eulenburg
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Blood Biomarkers May Have Found a New Frontier in Spaceflight. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Taylor R Zuidema,Megan E Huibregtse,Keisuke Kawata
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Prediction of Long-term Survival After Status Epilepticus Using the ACD Score. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Lars Egil Roberg,Olav Monsson,Simon Bang Kristensen,Svein Magne Dahl,Line Bédos Ulvin,Kjell Heuser,Erik Taubøll,Adam Strzelczyk,Susanne Knake,Lydia Bechert,Felix Rosenow,Dagmar Beier,Sandor Beniczky,Thomas Krøigård,Christoph Patrick Beier
Importance Early prediction of long-term mortality in status epilepticus is important given the high fatality rate in the years after diagnosis. Objective To improve prognostication of long-term mortality after status epilepticus diagnosis. Design, Settings, and Participants This retrospective, multicenter, multinational cohort study analyzed adult patients who were diagnosed with and treated for status
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Sleep Recording for the Diagnosis and Treatment of Paraplegia. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Raphaël Vollhardt,Isabelle Arnulf,Béatrice Garcin
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Postmortem Assessment of Olfactory Tissue Degeneration and Microvasculopathy in Patients With COVID-19. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Cheng-Ying Ho,Mohammad Salimian,Julia Hegert,Jennifer O'Brien,Sun Gyeong Choi,Heather Ames,Meaghan Morris,John C Papadimitriou,Joseph Mininni,Peter Niehaus,Allen Burke,Leyla Canbeldek,Jonathan Jacobs,Autumn LaRocque,Kavi Patel,Kathryn Rice,Ling Li,Robert Johnson,Alexandra LeFevre,Thomas Blanchard,Ciara M Shaver,Ann Moyer,Cinthia Drachenberg
Importance Loss of smell is an early and common presentation of COVID-19 infection. Although it has been speculated that viral infection of olfactory neurons may be the culprit, it is unclear whether viral infection causes injuries in the olfactory bulb region. Objective To characterize the olfactory pathology associated with COVID-19 infection in a postmortem study. Design, Setting, and Participants
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The Global Burden of Polyneuropathy-In Need of an Accurate Assessment. JAMA Neurol. (IF 18.302) Pub Date : 2022-06-01 Melissa A Elafros,Michelle P Kvalsund,Brian C Callaghan
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Identification and Treatment of Neonatal Seizures During Therapeutic Hypothermia and Rewarming. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Sourabh Verma,Sean M Bailey,Pradeep V Mally
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Identification and Treatment of Neonatal Seizures During Therapeutic Hypothermia and Rewarming-Reply. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Lina F Chalak
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Association of Maintenance Intravenous Immunoglobulin With Prevention of Relapse in Adult Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 John J Chen,Saif Huda,Yael Hacohen,Michael Levy,Itay Lotan,Adi Wilf-Yarkoni,Hadas Stiebel-Kalish,Mark A Hellmann,Elias S Sotirchos,Amanda D Henderson,Sean J Pittock,M Tariq Bhatti,Eric R Eggenberger,Marie Di Nome,Ho Jin Kim,Su-Hyun Kim,Albert Saiz,Friedemann Paul,Russell C Dale,Sudarshini Ramanathan,Jacqueline Palace,Valentina Camera,Maria Isabel Leite,Byron L Lam,Jeffrey L Bennett,Sara Mariotto,Dave
Importance Recent studies suggest that maintenance intravenous immunoglobulin (IVIG) may be an effective treatment to prevent relapses in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); however, most of these studies had pediatric cohorts, and few studies have evaluated IVIG in adult patients. Objective To determine the association of maintenance IVIG with the prevention of
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Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Jun Y Oh,Christine M Walsh,Kamalini Ranasinghe,Mihovil Mladinov,Felipe L Pereira,Cathrine Petersen,Neus Falgàs,Leslie Yack,Tia Lamore,Rakin Nasar,Caroline Lew,Song Li,Thomas Metzler,Quentin Coppola,Natalie Pandher,Michael Le,Hilary W Heuer,Helmut Heinsen,Salvatore Spina,William W Seeley,Joel Kramer,Gil D Rabinovici,Adam L Boxer,Bruce L Miller,Keith Vossel,Thomas C Neylan,Lea T Grinberg
Importance Sleep disturbance is common among patients with neurodegenerative diseases. Examining the subcortical neuronal correlates of sleep disturbances is important to understanding the early-stage sleep neurodegenerative phenomena. Objectives To examine the correlation between the number of important subcortical wake-promoting neurons and clinical sleep phenotypes in patients with Alzheimer disease
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Effect of Gamification With Social Incentives on Daily Steps After Stroke: A Randomized Clinical Trial. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Kimberly J Waddell,Mitesh S Patel,Kayla Clark,Tory O Harrington,S Ryan Greysen
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Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Eric L Ross,Marc S Weinberg,Steven E Arnold
Importance Several anti-amyloid monoclonal antibodies have been developed for slowing the progression of Alzheimer disease (AD). Among the furthest developed are aducanumab, which received accelerated approval from the US Food and Drug Administration in 2021, and donanemab, which is currently undergoing phase 3 trials. The cost-effectiveness of these treatments has not been established. Objectives
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Incidence and Natural History of Pediatric Large Vessel Occlusion Stroke: A Population Study. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Kartik D Bhatia,Romain Briest,Robert Goetti,Richard Webster,Christopher Troedson,Russell C Dale,Prakash Muthusami,Christina Miteff,Ferdinand Miteff,John Worthington,Kylie Tastula,Timothy Ang,Ian Andrews
Importance The incidence and natural history of large vessel occlusion (LVO) stroke in children is largely unknown. These knowledge gaps limit the uptake of reperfusion therapies and reduce the efficiency of pediatric acute stroke pathways. Objective To determine the incidence and natural history of pediatric LVO stroke. Design, Setting, and Participants This retrospective population-based cohort study
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Why Some Individuals With Tourette Syndrome Experience Assault and Perpetrate Criminal Behavior. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Davide Martino,James F Leckman,Michael S Okun
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Provocative Hyperventilation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Yonatan Serlin,Mohammed Alshahrani,Birgit Frauscher
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Association of Tourette Syndrome and Chronic Tic Disorder With Violent Assault and Criminal Convictions. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 David Mataix-Cols,Suvi Virtanen,Anna Sidorchuk,Lorena Fernández de la Cruz,Henrik Larsson,Paul Lichtenstein,Antti Latvala
Importance Tic disorders are associated with multiple social adversities, but little is known about the experience of violent assault (including sexual assault) and criminality in this group. Objective To establish if Tourette syndrome (TS) and chronic tic disorder (CTD) are associated with an increased risk of experiencing violent assault and criminal convictions. Design, Setting, and Participants
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Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Stefan Pszczolkowski,Nikola Sprigg,Lisa J Woodhouse,Rebecca Gallagher,David Swienton,Zhe Kang Law,Ana M Casado,Ian Roberts,David J Werring,Rustam Al-Shahi Salman,Timothy J England,Paul S Morgan,Philip M Bath,Robert A Dineen
Importance Hyperintense foci on diffusion-weighted imaging (DWI) that are spatially remote from the acute hematoma occur in 20% of people with acute spontaneous intracerebral hemorrhage (ICH). Tranexamic acid, a hemostatic agent that is under investigation for treating acute ICH, might increase DWI hyperintense lesions (DWIHLs). Objective To establish whether tranexamic acid compared with placebo increased
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Tranexamic Acid and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Stephanie E Oh,Santosh B Murthy
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A Conversation About Suicide During Medical Training. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Amole Khadilkar
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Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source: The Young ESUS Longitudinal Cohort Study. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Kanjana S Perera,Danielle de Sa Boasquevisque,Purnima Rao-Melacini,Amanda Taylor,Anna Cheng,Graeme J Hankey,Sarah Lee,Joan Marti Fabregas,Sebastian F Ameriso,Thalia S Field,Antonio Arauz,Shelagh B Coutts,Marcel Arnold,Robert Mikulik,Danilo Toni,Jennifer Mandzia,Roland C Veltkamp,Elena Meseguer,Karl Georg Haeusler,Robert G Hart,
Importance Cryptogenic strokes constitute approximately 40% of ischemic strokes in young adults, and most meet criteria for the embolic stroke of undetermined source (ESUS). Two randomized clinical trials, NAVIGATE ESUS and RESPECT ESUS, showed a high rate of stroke recurrence in older adults with ESUS but the prognosis and prognostic factors among younger individuals with ESUS is uncertain. Objective
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Traumatic Brain Injury in Older Adults-A Public Health Perspective. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Dana Waltzman,Juliet Haarbauer-Krupa,Lindsay S Womack
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Diagnostic Challenges and Uncertainties of Embolic Strokes of Undetermined Source in Young Adults. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 George Ntaios,Setareh Salehi Omran
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One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China: A Longitudinal Cohort Study. JAMA Neurol. (IF 18.302) Pub Date : 2022-05-01 Yu-Hui Liu,Yang Chen,Qing-Hua Wang,Ling-Ru Wang,Li Jiang,Ying Yang,Xian Chen,Ying Li,Yuan Cen,Cheng Xu,Jie Zhu,Wei Li,Ye-Ran Wang,Li-Li Zhang,Juan Liu,Zhi-Qiang Xu,Yan-Jiang Wang
Importance Determining the long-term impact of COVID-19 on cognition is important to inform immediate steps in COVID-19 research and health policy. Objective To investigate the 1-year trajectory of cognitive changes in older COVID-19 survivors. Design, Setting, and Participants This cohort study recruited 3233 COVID-19 survivors 60 years and older who were discharged from 3 COVID-19-designated hospitals
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Reversal of Imaging Findings of Idiopathic Intracranial Hypertension After Lumbar Puncture. JAMA Neurol. (IF 18.302) Pub Date : 2022-04-01 Anish Kapadia,Erin Wong,Chris Heyn
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Inducers and Cardiovascular Risk-Potential Role for Lowered Drug Exposure. JAMA Neurol. (IF 18.302) Pub Date : 2022-04-01 Lorenz Van der Linden,Julie Hias,Isabel Spriet
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Identifying Parkinson Risk Markers in Primary Care-Old Associations and New Insights. JAMA Neurol. (IF 18.302) Pub Date : 2022-04-01 Bhavana Patel,Shannon Chiu,Melissa J Armstrong
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Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population. JAMA Neurol. (IF 18.302) Pub Date : 2022-04-01 Cristina Simonet,Jonathan Bestwick,Mark Jitlal,Sheena Waters,Aaron Ben-Joseph,Charles R Marshall,Ruth Dobson,Soha Marrium,John Robson,Benjamin M Jacobs,Daniel Belete,Andrew J Lees,Gavin Giovannoni,Jack Cuzick,Anette Schrag,Alastair J Noyce
IMPORTANCE Early features of Parkinson disease (PD) have been described through population-based studies that overrepresent White, affluent groups and may not be generalizable. OBJECTIVE To investigate the association between risk factors and prediagnostic presentations of PD in an ethnically diverse UK population with high socioeconomic deprivation but universal access to health care. DESIGN, SETTING
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Inducers and Cardiovascular Risk-Potential Role for Lowered Drug Exposure-Reply. JAMA Neurol. (IF 18.302) Pub Date : 2022-04-01 Colin B Josephson,Mark R Keezer,Samuel Wiebe