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Correction: Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients Mol. Cancer (IF 41.444) Pub Date : 2022-08-10 Ouyang, Qing, Gong, Xueyang, Xiao, Hualiang, Zhou, Ji, Xu, Minhui, Dai, Yun, Xu, Lunshan, Feng, Hua, Cui, Hongjuan, Yi, Liang
Correction: Mol Cancer 14, 21 (2015) https://doi.org/10.1186/s12943-015-0290-8 Following publication of the original article [1], the authors subsequently identified an error in Figure 4A. The images representing U87 cells were taken from GL261 cells by mistake. The corrected Figure 4 is now shown in this correction. The authors confirm that the conclusions of this article are not affected, and sincerely
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Retraction Note to: Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner Mol. Cancer (IF 41.444) Pub Date : 2022-08-10 Fu, Xiaomin, Zhu, Xiaoyan, Qin, Fujun, Zhang, Yong, Lin, Jizhen, Ding, Yuechao, Yang, Zihe, Shang, Yiman, Wang, Li, Zhang, Qinxian, Gao, Quanli
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0783-3.
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TIPE3 is a candidate prognostic biomarker promoting tumor progression via elevating RAC1 in pancreatic cancer Mol. Cancer (IF 41.444) Pub Date : 2022-08-09 Li, Zequn, Cao, Shougen, Sun, Yuqi, Niu, Zhaojian, Liu, Xiaodong, Niu, Jun, Zhou, Yanbing
Pancreatic cancer (PC) is the most lethal solid tumor all around the world. Most of the PC patients always present unfavorable prognosis [1]. Although progress has been made in the comprehensive therapies of this devastating disease in recent decades, the absence of effective biomarkers still leads to poor prognosis [2, 3]. Surgical resection remains the main treatment, but nearly 70% ~ 80% patients
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Targeting KRAS mutant cancers: from druggable therapy to drug resistance Mol. Cancer (IF 41.444) Pub Date : 2022-08-04 Zhu, Chunxiao, Guan, Xiaoqing, Zhang, Xinuo, Luan, Xin, Song, Zhengbo, Cheng, Xiangdong, Zhang, Weidong, Qin, Jiang-Jiang
Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with drugs is challenging because KRAS is considered undruggable due to the lack of classic drug binding sites. Over the past 40 years, great efforts have been made to explore routes for indirect targeting of KRAS mutant cancers, including KRAS expression
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BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer Mol. Cancer (IF 41.444) Pub Date : 2022-08-02 Zhang, Yanmei, Fang, Mengdie, Li, Shouye, Xu, Hao, Ren, Juan, Tu, Linglan, Zuo, Bowen, Yao, Wanxin, Liang, Guang
Brother of regulator of imprinted sites (BORIS) is expressed in most cancers and often associated with short survival and poor prognosis in patients. BORIS inhibits apoptosis and promotes proliferation of cancer cells. However, its mechanism of action has not been elucidated, and there is no known inhibitor of BORIS. A phage display library was used to find the BORIS inhibitory peptides and BTApep-TAT
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Retraction Note: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer Mol. Cancer (IF 41.444) Pub Date : 2022-07-30 Liu, Tong, Zhang, Xin, Du, Lutao, Wang, Yunshan, Liu, Xiaoming, Tian, Hui, Wang, Lili, Li, Peilong, Zhao, Yinghui, Duan, Weili, Xie, Yujiao, Sun, Zhaowei, Wang, Chuanxin
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-019-0981-7.
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A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML Mol. Cancer (IF 41.444) Pub Date : 2022-07-29 Cai, Baohuan, Liu, Yun, Chong, Yating, Mori, Stephanie Fay, Matsunaga, Atsuko, Zhang, Hualei, Fang, Xuexiu, Chang, Chang-Sheng, Cowell, John K., Hu, Tianxiang
Myeloid and lymphoid malignancies associated with chimeric FGFR1 kinases are the hallmark of stem cell leukemia and lymphoma syndrome (SCLL). In all cases, FGFR1 kinase is constitutively phosphoactivated as a result of chromosome translocations, which lead to acquisition of dimerization motifs in the chimeric proteins. Recently, we demonstrated that these chimeric kinases could be cleaved by granzyme
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Correction: Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy Mol. Cancer (IF 41.444) Pub Date : 2022-07-28 Li, Heng, Yu, Gan, Shi, Runlin, Lang, Bin, Chen, Xianguo, Xia, Ding, Xiao, Haibing, Guo, Xiaolin, Guan, Wei, Ye, Zhangqun, Xiao, Wei, Xu, Hua
Correction: Mol Cancer 13, 8 (2014) https://doi.org/10.1186/1476-4598-13-8 Following publication of the original article [1], an error was identified in the images presented in Fig. 4, specifically: Fig. 4 MiR-34a functioned as a tumor suppressor in MIBC cells. A The effect of ectopic miR-34a expression on MIBC cell proliferation was investigated by CCK-8. The miR-34a activity was mediated by transfection
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Multiplex Epstein-Barr virus BALF2 genotyping detects high-risk variants in plasma for population screening of nasopharyngeal carcinoma Mol. Cancer (IF 41.444) Pub Date : 2022-07-28 Miller, Jacob A., Sahoo, Malaya K., Yamamoto, Fumiko, Huang, ChunHong, Wang, Hannah, Zehnder, James L., Le, Quynh-Thu, Pinsky, Benjamin A.
Epstein-Barr Virus (EBV)-associated nasopharyngeal carcinoma (NPC) exhibits unusual geographic restriction despite ubiquitous lifelong infection. Screening programs can detect most NPC cases at an early stage, but existing EBV diagnostics are limited by false positives and low positive predictive value (PPV), leading to excess screening endoscopies, MRIs, and repeated testing. Recent EBV genome-wide
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CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma Mol. Cancer (IF 41.444) Pub Date : 2022-07-25 Wang, Feng, Zhao, Fen, Zhang, Li, Xiong, Lai, Mao, Qing, Liu, Yanhui, Qiu, Xiaoguang, Wang, Xiang, Shui, Lin, Chen, Xi, Ren, Kexing, Shui, Pixian, Zhang, Qiongwen, Deng, Yifei, Li, Weimin, Xie, Xiaoqi, Wu, Dengbin, Li, Tao, Lang, Jinyi, Liu, Lei, Chen, Huaying, Xu, Jianguo, Bai, Sen, Li, Zhiping, Yue, Qiang, Chen, Ni, Zhou, Bingwen, Yi, Cheng, Wei, Yuquan, Fu, Yuchuan, Luo, Yong, Gou, Qiheng, Liu,
Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. However, it’s role in glioma, which is ranked as one of the common primary malignant tumor in the central nervous system and is associated with high morbidity and mortality, is unclear. In this study, we explored CDC6 gene expression level in pan-cancer. Furthermore, we focused
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A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions Mol. Cancer (IF 41.444) Pub Date : 2022-07-22 Donzelli, Sara, Cioce, Mario, Sacconi, Andrea, Zanconato, Francesca, Daralioti, Theodora, Goeman, Frauke, Orlandi, Giulia, Di Martino, Simona, Fazio, Vito Michele, Alessandrini, Gabriele, Telera, Stefano, Carosi, Mariantonia, Ciliberto, Gennaro, Botti, Claudio, Strano, Sabrina, Piccolo, Stefano, Blandino, Giovanni
Breast cancer (BC) is a powerful example of the intra- and interpatient heterogeneity of tumours; thus, there remain several grey areas in BC treatment approaches. This is especially true for advanced/metastatic disease (mBC) [1,2,3]. Organoid cultures are suitable models for studying the histological complexity and genetic heterogeneity of parental tumours and can be used to assess treatment strategies
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E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer Mol. Cancer (IF 41.444) Pub Date : 2022-07-22 Wang, Haibo, Yang, Wenjing, Qin, Qiong, Yang, Xiaomei, Yang, Ying, Liu, Hua, Lu, Wenxiu, Gu, Siyu, Cao, Xuedi, Feng, Duiping, Zhang, Zhongtao, He, Junqi
Recurrence and chemoresistance constitute the leading cause of death in colorectal cancer (CRC). Thus, it is of great significance to clarify the underlying mechanisms and identify predictors for tailoring adjuvant chemotherapy to improve the outcome of CRC. By screening differentially expressed genes (DEGs), constructing random forest classification and ranking the importance of DEGs, we identified
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MARCKSL1–2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b Mol. Cancer (IF 41.444) Pub Date : 2022-07-21 Jiang, Min, Qi, Feng, Zhang, Kai, Zhang, Xiaofei, Ma, Jingjing, Xia, Suhua, Chen, Longbang, Yu, Zhengyuan, Chen, Jing, Chen, Dongqin
Long non-coding RNAs (lncRNAs) are implicated in the development of multiple cancers. In our previous study, we demonstrated that HDAC1/4-mediated silencing of microRNA-200b (miR-200b) enhances docetaxel (DTX)-resistance of human lung adenocarcinoma (LAD) cells. Herein, we probed the function of LncRNA MARCKSL1–2 (MARCKSL1-transcript variant 2, NR_052852.1) in DTX resistance of LAD cells. It was found
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CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma Mol. Cancer (IF 41.444) Pub Date : 2022-07-20 Liu, Lianyong, Gu, Mingjun, Ma, Junhua, Wang, Ying, Li, Miao, Wang, Hui, Yin, Xin, Li, Xiangqi
Emerging evidence indicates that circular RNAs (circRNAs) and m6A RNA methylation participate in the pathogenesis and metastasis of multiple malignancies including hepatocellular carcinoma (HCC). However, it remains undocumented how circRNAs form a feedback loop with the m6A modification contributing to HCC. A novel hsa_circ_0017114 (circGPR137B) was identified from three pairs of primary HCC and adjacent
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Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance Mol. Cancer (IF 41.444) Pub Date : 2022-07-18 Lin, Hong, Wang, Yuxi, Wang, Pinghan, Long, Fangyi, Wang, Ting
The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of therapeutic resistance may provide new strategies for overcoming cancer resistance. N6-methyladenosine (m6A) is the most prevalent RNA modification in eukaryotes, and is involved in the regulation of RNA splicing, translation
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LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer Mol. Cancer (IF 41.444) Pub Date : 2022-07-16 Sun, Zeguo, Zhang, Rui, Zhang, Xiao, Sun, Yifei, Liu, Pengpeng, Francoeur, Nancy, Han, Lei, Lam, Wan Yee, Yi, Zhengzi, Sebra, Robert, Walsh, Martin, Yu, Jinpu, Zhang, Weijia
Long Interspersed Nuclear Element-1 (LINE-1, L1) is increasingly regarded as a genetic risk for lung cancer. Transcriptionally active LINE-1 forms a L1-gene chimeric transcript (LCTs), through somatic L1 retrotransposition (LRT) or L1 antisense promoter (L1-ASP) activation, to play an oncogenic role in cancer progression. Here, we developed Retrotransposon-gene fusion estimation program (ReFuse), to
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Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway Mol. Cancer (IF 41.444) Pub Date : 2022-07-15 Xu, Zhipeng, Chen, Shuqiu, Liu, Ruiji, Chen, Hui, Xu, Bin, Xu, Weizhang, Chen, Ming
Increasing evidence has demonstrated that circular RNAs (circRNAs) are implicated in cancer progression. However, the aberrant expression and biological functions of circRNAs in clear cell renal cell carcinoma (cRCC) remain largely elusive. Differentially expressed circRNAs in cRCC were filtered via bioinformatics analysis. Aberrant circPOLR2A expression was validated in cRCC tissues and cell lines
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CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p Mol. Cancer (IF 41.444) Pub Date : 2022-07-15 Xi, Yong, Shen, Yaxing, Wu, Donglei, Zhang, Jingtao, Lin, Chengbin, Wang, Lijie, Yu, Chaoqun, Yu, Bentong, Shen, Weiyu
Circular RNAs (circRNAs) have been demonstrated to contribute to esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted to be differentially expressed in esophageal cancer by bioinformatics analysis. We investigated the oncogenic roles and biogenesis of circBCAR3 in esophageal carcinogenesis. Functions of circBCAR3 on cancer cell proliferation, migration, invasion, and ferroptosis
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target Mol. Cancer (IF 41.444) Pub Date : 2022-07-14 Zhao, Hui, Ming, Tianqi, Tang, Shun, Ren, Shan, Yang, Han, Liu, Maolun, Tao, Qiu, Xu, Haibo
The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults. The canonical Wnt signaling pathway regulates cell pluripotency and determines the differentiation fate of cells during development. The canonical Wnt signaling pathway (also known as the Wnt/β-catenin
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Retraction Note to: Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation Mol. Cancer (IF 41.444) Pub Date : 2022-07-11 Han, Mingli, Gu, Yuanting, Lu, Pengwei, Li, Jingyi, Cao, Hui, Li, Xiangke, Qian, Xueke, Yu, Chao, Yang, Yunqing, Yang, Xue, Han, Na, Dou, Dongwei, Hu, Jianguo, Dong, Huaying
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-020-1145-5.
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Retraction Note to: The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression Mol. Cancer (IF 41.444) Pub Date : 2022-07-08 Yang, Rui, Xing, Lei, Zheng, Xiaying, Sun, Yan, Wang, Xiaosong, Chen, Junxia
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0933-7.
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Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1 Mol. Cancer (IF 41.444) Pub Date : 2022-07-02 Zang, Xueyan, Jiang, Jiajia, Gu, Jianmei, Chen, Yanke, Wang, Maoye, Zhang, Yu, Fu, Min, Shi, Hui, Cai, Hui, Qian, Hui, Xu, Wenrong, Zhang, Xu
Increasing studies suggest that circular RNAs (circRNAs) are critical regulators of cancer development and progression. However, the biological roles and mechanisms of circRNAs in gastric cancer (GC) remain largely unknown. We identified the differentially expressed circRNAs in GC by analyzing Gene Expression Omnibus (GEO) datasets. We explored the biological roles of circRNAs in GC by in vitro functional
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CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA Mol. Cancer (IF 41.444) Pub Date : 2022-06-30 Yao, Bing, Zhang, Qinglin, Yang, Zhou, An, Fangmei, Nie, He, Wang, Hui, Yang, Cheng, Sun, Jing, Chen, Ke, Zhou, Jingwan, Bai, Bing, Gu, Shouyong, Zhao, Wei, Zhan, Qiang
Aberrant expression of circular RNAs (circRNAs) contributes to the initiation and progression of human malignancies, but the underlying mechanisms remain largely elusive. High-throughput sequencing was performed to screen aberrantly expressed circRNAs or miRNAs in colorectal cancer (CRC) and adjacent normal tissues. A series of gain- and loss-of-function studies were conducted to evaluate the biological
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Retraction Note to: Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer Mol. Cancer (IF 41.444) Pub Date : 2022-06-29 Dong, Huaying, Hu, Jianguo, Zou, Kejian, Ye, Mulin, Chen, Yuanwen, Wu, Chengyi, Chen, Xin, Han, Mingli
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0931-9.
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Ceritinib is a novel triple negative breast cancer therapeutic agent Mol. Cancer (IF 41.444) Pub Date : 2022-06-29 Dong, Shengli, Yousefi, Hassan, Savage, Isabella Van, Okpechi, Samuel C., Wright, Maryl K., Matossian, Margarite D., Collins-Burow, Bridgette M., Burow, Matthew E., Alahari, Suresh K.
Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of commonly targeted therapies within this subtype. Androgen receptor (AR) has been detected in 12–55% of TNBCs. AR stimulates breast tumor growth in the absence of estrogen receptor (ER), and it has become an emerging molecular target in TNBC treatment
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circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer Mol. Cancer (IF 41.444) Pub Date : 2022-06-29 Wu, Mengting, Qiu, Qiongzi, Zhou, Qing, Li, Jia, Yang, Juze, Zheng, Chengcai, Luo, Aoran, Li, Xufan, Zhang, Honghe, Cheng, Xiaodong, Lu, Weiguo, Liu, Pengyuan, Lu, Bingjian, Lu, Yan
CircRNAs are a novel class of evolutionarily conserved noncoding RNA molecules that form covalently closed continuous loop structures without 5′ caps and 3′ poly(A) tails. Accumulating evidence suggests that circRNAs play important regulatory roles in cancer and are promising biomarkers for cancer diagnosis and prognosis, as well as targets for cancer therapy. In this study, we identify and explore
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Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge Mol. Cancer (IF 41.444) Pub Date : 2022-06-24 Jiang, Junfeng, Zeng, Tao, Zhang, Li, Fan, Xingfei, Jin, Qishu, Ni, Haitao, Ye, Yusheng, Cheng, Lipeng, Li, Li, Wang, Liujun, Xu, Sha, Yang, Yu, Gu, Juan, Guo, Bing, Wang, Lei, Li, Xin, Qin, Yingyi, Li, Jiaxi, Wang, Jinjiang, Chen, Xi, Wu, Minjuan, Ying, Qi-long, Qin, Xingjun, Wang, Yefei, Wang, Yue
Cas9 RNA functions as a miRNA sponge. Let-7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous mutation improves its safety.
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circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop Mol. Cancer (IF 41.444) Pub Date : 2022-06-23 Li, Xiaomin, Wang, Jianjun, Lin, Weihao, Yuan, Qinzi, Lu, Yanxia, Wang, Haowei, Chen, Yujia, Chen, Lixia, Dai, Peiling, Long, Huaicheng, Li, Xuenong
In recent years, an increasing number of studies have indicated that circular RNA plays crucial roles in regulating tumor development and chemoresistance. Using two high-throughput RNA sequence datasets, we previously found that circEXOC6B was downregulated in colon cancer. However, its role and mechanism in colorectal cancer (CRC) remained unknown. Real-time quantitative PCR was used to examine the
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Correction: A novel approach for relapsed/refractory FLT3mut+acute myeloid leukaemia: synergistic effect of the combination of bispecific FLT3scFv/NKG2D-CAR T cells and gilteritinib Mol. Cancer (IF 41.444) Pub Date : 2022-06-23 Li, Ke-xin, Wu, Hui-yang, Pan, Wan-ying, Guo, Meng-qi, Qiu, De-zhi, He, Yan-jie, Li, Yu-hua, Yang, Dong-Hua, Huang, Yu-xian
Correction: Mol Cancer 21, 66 (2022) https://doi.org/10.1186/s12943-022-01541-9 Following publication of the original article [1], the authors identified minor errors in Figs. 3, 4, 5 and Additional file 5: Figure S5, and Additional file 14: Table S4; specifically: Fig. 3B: 'Control' panel was originally a duplicate of the Giliteritinib panel; this has been replaced by the correct images Fig. 4A: The
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Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells Mol. Cancer (IF 41.444) Pub Date : 2022-06-22 Wang, Xinbo, Miao, Jiaying, Wang, Sizhen, Shen, Rongxi, Zhang, Shuo, Tian, Yurao, Li, Min, Zhu, Daojun, Yao, Anlong, Bao, Wei, Zhang, Qun, Tang, Xingming, Wang, Xingyun, Li, Jieshou
Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features. In this study, single-cell RNA sequencing (scRNA-seq) was used to profile the distinct tumor microenvironment of UCOGCP using samples obtained from one UCOGCP patient and three PDAC patients
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Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer Mol. Cancer (IF 41.444) Pub Date : 2022-06-18 Heidegger, Isabel, Fotakis, Georgios, Offermann, Anne, Goveia, Jermaine, Daum, Sophia, Salcher, Stefan, Noureen, Asma, Timmer-Bosscha, Hetty, Schäfer, Georg, Walenkamp, Annemiek, Perner, Sven, Beatovic, Aleksandar, Moisse, Matthieu, Plattner, Christina, Krogsdam, Anne, Haybaeck, Johannes, Sopper, Sieghart, Thaler, Stefanie, Keller, Markus A., Klocker, Helmut, Trajanoski, Zlatko, Wolf, Dominik, Pircher
Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes that contribute to PCa tumor microenvironment (TME) alterations. Here we performed a detailed characterization of PCa tumor endothelial cells (TEC) to delineate intercellular crosstalk between TEC
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Retraction Note to: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis Mol. Cancer (IF 41.444) Pub Date : 2022-06-17 Liang, Yiran, Song, Xiaojin, Li, Yaming, Chen, Bing, Zhao, Wenjing, Wang, Lijuan, Zhang, Hanwen, Liu, Ying, Han, Dianwen, Zhang, Ning, Ma, Tingting, Wang, Yajie, Ye, Fangzhou, Luo, Dan, Li, Xiaoyan, Yang, Qifeng
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-020-01206-5
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Correction: m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC Mol. Cancer (IF 41.444) Pub Date : 2022-06-13 Jin, Dan, Guo, Jiwei, Wu, Yan, Yang, Lijuan, Wang, Xiaohong, Du, Jing, Dai, Juanjuan, Chen, Weiwei, Gong, Kaikai, Miao, Shuang, Li, Xuelin, Sun, Hongliang
Correction: Mol Cancer 19, 40 (2020) https://doi.org/10.1186/s12943-020-01161-1 Following publication of the original article [1], the authors identified minor errors in Figs. 1 and 5; specifically: Fig. 1 Ectopic expression of YAP and ALKBH5 regulates cell proliferation, invasion, migration, and EMT in NSCLC cells. a The mRNA and protein levels of YAP and ALKBH5 were analyzed by RT-PCR and western
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Letter to the Editor: An ultra-sensitive assay using cell-free DNA fragmentomics for multi-cancer early detection Mol. Cancer (IF 41.444) Pub Date : 2022-06-11 Bao, Hua, Wang, Zheng, Ma, Xiaoji, Guo, Wei, Zhang, Xiangyu, Tang, Wanxiangfu, Chen, Xin, Wang, Xinyu, Chen, Yikuan, Mo, Shaobo, Liang, Naixin, Ma, Qianli, Wu, Shuyu, Xu, Xiuxiu, Chang, Shuang, Wei, Yulin, Zhang, Xian, Bao, Hairong, Liu, Rui, Yang, Shanshan, Jiang, Ya, Wu, Xue, Li, Yaqi, Zhang, Long, Tan, Fengwei, Xue, Qi, Liu, Fangqi, Cai, Sanjun, Gao, Shugeng, Peng, Junjie, Zhou, Jian, Shao, Yang
Early detection can benefit cancer patients with more effective treatments and better prognosis, but existing early screening tests are limited, especially for multi-cancer detection. This study investigated the most prevalent and lethal cancer types, including primary liver cancer (PLC), colorectal adenocarcinoma (CRC), and lung adenocarcinoma (LUAD). Leveraging the emerging cell-free DNA (cfDNA)
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Correction: lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer Mol. Cancer (IF 41.444) Pub Date : 2022-06-10 Ren, Xiaofan, Chen, Changhao, Luo, Yuming, Liu, Mingyang, Li, Yuting, Zheng, Shangyou, Ye, Huilin, Fu, Zhiqiang, Li, Min, Li, Zhihua, Chen, Rufu
Correction: Mol Cancer 19, 35 (2020) https://doi.org/10.1186/s12943-020-01153-1 Following publication of the original article [1], errors were identified in the images presented in Figs. 2 and 6; specifically: Fig. 2K: overlap was found between the Transwell migration assay and invasion assay in si-PLACT1#1 group of AsPC-1 cells; the representative image of the invasion assay in si-PLACT1#1 group of
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PRMT7: a survive-or-die switch in cancer stem cells Mol. Cancer (IF 41.444) Pub Date : 2022-06-10 Nicot, Christophe
Cancer stem-like cells (CSCs) are involved in initiation, resistance and relapse of cancer [1, 2]. Identifying targets uniquely expressed in CSCs, instead their normal counterparts, has been puzzling the field of cancer biology. In the quintessential paradigm of CSCs in chronic myeloid leukemia (CML), resistance at least partially conferred by leukemia stem cells (LSCs) remains an increasing threat
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Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells Mol. Cancer (IF 41.444) Pub Date : 2022-06-10 Berlak, Mareike, Tucker, Elizabeth, Dorel, Mathurin, Winkler, Annika, McGearey, Aleixandria, Rodriguez-Fos, Elias, da Costa, Barbara Martins, Barker, Karen, Fyle, Elicia, Calton, Elizabeth, Eising, Selma, Ober, Kim, Hughes, Deborah, Koutroumanidou, Eleni, Carter, Paul, Stankunaite, Reda, Proszek, Paula, Jain, Neha, Rosswog, Carolina, Dorado-Garcia, Heathcliff, Molenaar, Jan Jasper, Hubank, Mike, Barone
Development of resistance to targeted therapies has tempered initial optimism that precision oncology would improve poor outcomes for cancer patients. Resistance mechanisms, however, can also confer new resistance-specific vulnerabilities, termed collateral sensitivities. Here we investigated anaplastic lymphoma kinase (ALK) inhibitor resistance in neuroblastoma, a childhood cancer frequently affected
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CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway Mol. Cancer (IF 41.444) Pub Date : 2022-06-09 Del Gaudio, Nunzio, Di Costanzo, Antonella, Liu, Ning Qing, Conte, Lidio, Dell’Aversana, Carmela, Bove, Guglielmo, Benedetti, Rosaria, Montella, Liliana, Ciardiello, Fortunato, Carafa, Vincenzo, Ambrosino, Concetta, Tucci, Valeria, Conte, Mariarosaria, Martens, Joost H. A., Stunnenberg, Hendrik G., Nebbioso, Angela, Altucci, Lucia
The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers involved in leukemogenesis may thus provide new anticancer strategies. Accumulating evidence suggests that the PRC1 complex member CBX2 is overexpressed in solid tumors and
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Correction: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1 Mol. Cancer (IF 41.444) Pub Date : 2022-06-07 Xia, Xin, Li, Xixi, Li, Fanying, Wu, Xujia, Zhang, Maolei, Zhou, Huangkai, Huang, Nunu, Yang, Xuesong, Xiao, Feizhe, Liu, Dawei, Yang, Lixuan, Zhang, Nu
Correction to: Mol Cancer 18, 131 (2019) https://doi.org/10.1186/s12943-019-1056-5 Following publication of the original article [1], errors were identified in the images presented in Figs. 3 and 4; specifically: Fig. 3C Representative images showing plate colony formations from different cell lines were incorrectly selected during figure assembly; this affects circ-AKT3 IRES mut U373 (bottom left
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CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis Mol. Cancer (IF 41.444) Pub Date : 2022-06-06 Hua, Jinghan, Wang, Xiaolin, Ma, Liying, Li, Jingxin, Cao, Guozhen, Zhang, Shaobo, Lin, Wenchu
Multiple lines of evidence have demonstrated that circular RNAs (circRNAs) play oncogenic or tumor-suppressive roles in various human cancers. Nevertheless, the biological functions of circRNAs in small cell lung cancer (SCLC) are still elusive. CircVAPA (annotated as hsa_circ_0006990) was identified by mining the circRNA profiling dataset of six paired SCLC tissues and the RNA-seq data of serum samples
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Correction to: Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription Mol. Cancer (IF 41.444) Pub Date : 2022-06-02 Huang, Xince, He, Min, Huang, Shuai, Lin, Ruirong, Zhan, Ming, Yang, Dong, Shen, Hui, Xu, Sunwang, Cheng, Wei, Yu, Jianxiu, Qiu, Zilong, Wang, Jian
Correction to: Mol Cancer 18, 166 (2019) https://doi.org/10.1186/s12943-019-1098-8 Following the publication of the article [1], the authors identified an error in the author name of Min He, which was originally presented as ‘Ming He’. The corrected author list can be found here. The original article has been corrected. Huang X, He M, Huang S, et al. Circular RNA circERBB2 promotes gallbladder cancer
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CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2 Mol. Cancer (IF 41.444) Pub Date : 2022-06-01 Meng, Lingdong, Zhang, Yihan, Wu, Pengfei, Li, Danrui, Lu, Yichao, Shen, Peng, Yang, Taoyue, Shi, Guodong, Chen, Qun, Yuan, Hao, Ge, Wanli, Miao, Yi, Tu, Min, Jiang, Kuirong
circular RNAs (circRNAs) have been reported to play crucial roles in the biology of different cancers. However, little is known about the function of circSTX6 (hsa_circ_0007905) in pancreatic ductal adenocarcinoma (PDAC). circSTX6, a circRNA containing exons 4, 5, 6 and 7 of the STX6 gene, was identified by RNA sequencing and detected by quantitative reverse transcription PCR (qRT–PCR). The biological
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AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p Mol. Cancer (IF 41.444) Pub Date : 2022-05-27 Chou, Jinjiang, Kaller, Markus, Jaeckel, Stephanie, Rokavec, Matjaz, Hermeking, Heiko
AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC. Here, we set out to determine the relevance of AP4 in human colorectal cancer (CRC) cells. A CRISPR/Cas9 approach was employed to generate AP4-deficient CRC cell lines with inducible expression of c-MYC. Colony formation, β-gal staining
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The circSPON2/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression Mol. Cancer (IF 41.444) Pub Date : 2022-05-27 Yao, Bing, Zhu, Sha, Wei, Xiyi, Chen, Ming-Kun, Feng, Yangkun, Li, Zhimin, Xu, Xinyu, Zhang, Yuwei, Wang, Yang, Zhou, Jingwan, Tang, Ningyuan, Ji, Chengjian, Jiang, Peng, Zhao, Shan-Chao, Qin, Chao, Feng, Ninghan
Prostate cancer (PCa) is the most frequently diagnosed malignancy in men, and its mechanism remains poorly understood. Therefore, it is urgent to discover potential novel diagnostic biomarkers and therapeutic targets that can potentially facilitate the development of efficient anticancer strategies. A series of functional in vitro and in vivo experiments were conducted to evaluate the biological behaviors
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PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN Mol. Cancer (IF 41.444) Pub Date : 2022-05-26 Chong, Xiaodan, Chen, Jingde, Zheng, Nanxin, Zhou, Zhuqing, Hai, Yanan, Chen, Shiqing, Zhang, Yu, Yu, Qingzhuo, Yu, Shijun, Chen, Zhiqin, Bao, Wenfang, Quan, Ming, Chen, Zhe-Sheng, Zhan, Yangyang, Gao, Yong
PIK3CA mutation and PTEN suppression lead to tumorigenesis and drug resistance in colorectal cancer (CRC). There is no research on the role of circular RNAs (circRNAs) in regulating PIK3CA mutation and MEK inhibitor resistance in CRC. The expression of circLHFPL2 in PIK3CA-mutant and wild-type cells and tissues was quantified by RNA-sequencing and qRT-PCR. CCK-8 assay and colony formation assay were
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The clinical utility of dynamic ctDNA monitoring in inoperable localized NSCLC patients Mol. Cancer (IF 41.444) Pub Date : 2022-05-19 Yang, Yin, Zhang, Tao, Wang, Jingbo, Wang, Jianyang, Xu, Yang, Zhao, Xiaotian, Ou, Qiuxiang, Shao, Yang, Wang, Xin, Wu, Yuqi, Wu, Linfang, Xu, Xin, Xu, Kunpeng, Zhao, Jingjing, Wang, Luhua, Bi, Nan
Approximately one-third of the non-small cell lung cancer (NSCLC) patients are diagnosed with inoperable localized disease [1], and definitive chemoradiotherapy (CRT) is the standard of care for these patients. Although the results of the PACIFIC trial, a randomized multi-centre phase III trial evaluating the role of anti-PD-L1 (programmed cell death-ligand 1) antibody in patients with unresectable
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Clustering cancers by shared transcriptional risk reveals novel targets for cancer therapy Mol. Cancer (IF 41.444) Pub Date : 2022-05-18 Gao, Hua, Baylis, Richard A., Luo, Lingfeng, Kojima, Yoko, Bell, Caitlin F., Ross, Elsie G., Wang, Fudi, Leeper, Nicholas J.
The pursuit of targeted cancer therapies has greatly benefitted from the existence of large transcriptomic datasets, such as The Cancer Genome Atlas (TCGA), which have enabled the correlation of intra-tumoral gene expression with patient survival. Here, we use pathway enrichment data to identify three distinct groups of cancers characterized by cluster-specific biology and diverging mortality rates
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Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives Mol. Cancer (IF 41.444) Pub Date : 2022-05-17 Song, Jia, Ge, Yuexin, Sun, Xiaoyu, Guan, Qiutong, Gong, Shiqiang, Wei, Minjie, Niu, Jumin, Zhao, Lin
Cancer is a type of malignant affliction threatening human health worldwide; however, the molecular mechanism of cancer pathogenesis remains to be elusive. The oncogenic hedgehog (Hh) pathway is a highly evolutionarily conserved signaling pathway in which the hedgehog-Patched complex is internalized to cellular lysosomes for degradation, resulting in the release of Smoothened inhibition and producing
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Potential clinical utility of liquid biopsies in ovarian cancer Mol. Cancer (IF 41.444) Pub Date : 2022-05-11 Zhu, Jie Wei, Charkhchi, Parsa, Akbari, Mohammad R.
Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. One of the main challenges in the management of OC is the late clinical presentation of disease that results in poor survival. Conventional tissue biopsy methods and serological biomarkers such as CA-125 have limited clinical applications. Liquid biopsy is a novel sampling method that analyzes distinctive tumour components released
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Liquid biopsies to occult brain metastasis Mol. Cancer (IF 41.444) Pub Date : 2022-05-10 Rehman, Asad Ur, Khan, Parvez, Maurya, Shailendra Kumar, Siddiqui, Jawed A., Santamaria-Barria, Juan A., Batra, Surinder K., Nasser, Mohd Wasim
Brain metastasis (BrM) is a major problem associated with cancer-related mortality, and currently, no specific biomarkers are available in clinical settings for early detection. Liquid biopsy is widely accepted as a non-invasive method for diagnosing cancer and other diseases. We have reviewed the evidence that shows how the molecular alterations are involved in BrM, majorly from breast cancer (BC)
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Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer Mol. Cancer (IF 41.444) Pub Date : 2022-05-10 Gu, Jianyou, Huang, Wenjie, Wang, Xianxing, Zhang, Junfeng, Tao, Tian, Zheng, Yao, Liu, Songsong, Yang, Jiali, Chen, Zhe-Sheng, Cai, Chao-Yun, Li, Jinsui, Wang, Huaizhi, Fan, Yingfang
Although gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to gemcitabine severely limits the effectiveness of this chemotherapy, and the underlying mechanism of gemcitabine resistance remains unclear. Various factors, such as ATP binding cassette (ABC) transporters, microRNAs and their downstream signaling pathways are included in
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N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma Mol. Cancer (IF 41.444) Pub Date : 2022-05-10 Chen, Yuanlei, Lu, Zeyi, Qi, Chao, Yu, Chenhao, Li, Yang, Huan, Wang, Wang, Ruyue, Luo, Wenqin, Shen, Danyang, Ding, Lifeng, Ren, Liangliang, Xie, Haiyun, Xue, Dingwei, Wang, Mingchao, Ni, Kangxin, Xia, Liqun, Qian, Jun, Li, Gonghui
Sunitinib resistance can be classified into primary and secondary resistance. While accumulating research has indicated several underlying factors contributing to sunitinib resistance, the precise mechanisms in renal cell carcinoma are still unclear. RNA sequencing and m6A sequencing were used to screen for functional genes involved in sunitinib resistance. In vitro and in vivo experiments were carried
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The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis Mol. Cancer (IF 41.444) Pub Date : 2022-05-07 Zhang, Ling-Xian, Gao, Jian, Long, Xiang, Zhang, Peng-Fei, Yang, Xin, Zhu, Shu-Qiang, Pei, Xu, Qiu, Bai-Quan, Chen, Shi-Wei, Lu, Feng, Lin, Kun, Xu, Jian Jun, Wu, Yong-Bing
Previous studies have confirmed the oncogenic role of HMGB2 in various cancers, but the biological functions of HMGB2-derived circRNAs remain unknown. Thus, we intended to investigate the potential role of HMGB2-derived circRNAs in lung adenocarcinomas (LUAD) and squamous cell carcinomas (LUSC). The expression profiles of HMGB2-derived circRNAs in LUAD and LUSC tissues and matched normal tissues were
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M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma Mol. Cancer (IF 41.444) Pub Date : 2022-05-06 Du, Ashuai, Li, Shiqin, Zhou, Yuzheng, Disoma, Cyrollah, Liao, Yujie, Zhang, Yongxing, Chen, Zongpeng, Yang, Qinglong, Liu, Pinjia, Liu, Sixu, Dong, Zijun, Razzaq, Aroona, Tao, Siyi, Chen, Xuan, Liu, Yuxin, Xu, Lunan, Zhang, Qianjun, Li, Shanni, Peng, Jian, Xia, Zanxian
Emerging evidence suggest the critical role of circular RNAs (circRNAs) in disease development especially in various cancers. However, the oncogenic role of circRNAs in hepatocellular carcinoma (HCC) is still largely unknown. RNA sequencing was performed to identify significantly upregulated circRNAs in paired HCC tissues and non-tumor tissues. CCK-8 assay, colony formation, transwell, and xenograft
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The functional roles of the circRNA/Wnt axis in cancer Mol. Cancer (IF 41.444) Pub Date : 2022-05-05 Xue, Chen, Li, Ganglei, Zheng, Qiuxian, Gu, Xinyu, Bao, Zhengyi, Lu, Juan, Li, Lanjuan
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer
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circRNAs shed light on cancer diagnosis and treatment Mol. Cancer (IF 41.444) Pub Date : 2022-04-29 Nicot, Christophe
Circular RNAs (circRNAs) are a subgroup of single-stranded endogenous RNAs which exert differential expression pattern between normal and cancerous tissues and function as important regulators in cancer initiation and progression. However, comprehensive characterization of circRNA landscape across cancer types is still lacking. In a recent article published in Molecular Cancer, Wang and his colleagues
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An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer Mol. Cancer (IF 41.444) Pub Date : 2022-04-27 Wang, Wenjing, Wang, Jianmin, Liu, Shuai, Ren, Yong, Wang, Jingyu, Liu, Sen, Cui, Wei, Jia, Lina, Tang, Xing, Yang, Jingyu, Wu, Chunfu, Wang, Lihui
Lung cancer is a kind of malignancy with high morbidity and mortality worldwide. Paclitaxel (PTX) is the main treatment for non-small cell lung cancer (NSCLC), and resistance to PTX seriously affects the survival of patients. However, the underlying mechanism and potential reversing strategy need to be further explored. We identified ALDH2 as a PTX resistance-related gene using gene microarray analysis
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Long noncoding RNA TLNC1 promotes the growth and metastasis of liver cancer via inhibition of p53 signaling Mol. Cancer (IF 41.444) Pub Date : 2022-04-27 Yuan, Kefei, Lan, Jiang, Xu, Lin, Feng, Xuping, Liao, Haotian, Xie, Kunlin, Wu, Hong, Zeng, Yong
Long non-coding RNAs (lncRNAs) have been demonstrated to play vital roles in cancer development and progression. However, their biological roles and function mechanisms in liver cancer remain largely unknown. RNA-seq was performed with clinical hepatoma tissues and paired adjacent normal liver tissues to identify differentially expressed lncRNAs. qPCR was utilized to examine the expression levels of
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Targeting TGF-β signal transduction for fibrosis and cancer therapy Mol. Cancer (IF 41.444) Pub Date : 2022-04-23 Peng, Dandan, Fu, Minyang, Wang, Manni, Wei, Yuquan, Wei, Xiawei
Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis. The role of TGF-β in fibrosis and cancer is complex and sometimes even contradictory, exhibiting either inhibitory or promoting effects depending on the stage of the disease. Under pathological conditions
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CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells Mol. Cancer (IF 41.444) Pub Date : 2022-04-22 Zhang, Lei, Li, Yidong, Hu, Chaohua, Chen, Yangmin, Chen, Zhuo, Chen, Zhe-Sheng, Zhang, Jian-Ye, Fang, Shuo
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1/P-gp) is a major cause of cancer chemotherapy failure, but the regulation mechanisms are largely unknown. Based on single gene knockout, we studied the regulation of CDK6-PI3K axis on ABCB1-mediated MDR in human cancer cells. CRISPR/Cas9 technique was performed in KB-C2 cells to knockout cdk6 or cdk4 gene. Western