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Continence criteria of 193,618 patients after open, laparoscopic, and robotic radical prostatectomy BJU Int. (IF 4.5) Pub Date : 2023-09-15 Tomás B. C. Moretti, Luís A. Magna, Leonardo O. Reis
to apply a new evidence-gathering methodology, called reverse systematic review (RSR), to analyze the influence of different continence classification criteria on urinary continence rates among open (RRP), laparoscopic (LRP) and robotic (RARP) radical prostatectomy.
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Global Viewpoints: Updates on Prostate cancer in Sub-Saharan Africa BJU Int. (IF 4.5) Pub Date : 2023-09-13 Mohamed Jalloh, Ayun Cassell, Lamine Niang, Timothy Rebbeck
Prostate cancer is a major health concern in Sub-Saharan Africa (SSA), with high incidence and mortality rates. However, the widely used prostate-specific antigen (PSA) screening is not readily available or affordable in SSA. Alternative screening strategies, such as risk stratification approaches and cost-effective PSA tests, are being explored to target high-risk individuals and improve access to
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Transperineal template saturation and conventional biopsy for stage prediction in prostate cancer BJU Int. (IF 4.5) Pub Date : 2023-09-13 F. Lehner, A. Crippa, S. Sigg, D. Eberli, A. Mortezavi
To evaluate the performance of risk calculators (RCs) predicting lymph node invasion (LNI) and extraprostatic extension (EPE) in men undergoing transperineal MRI/TRUS-fusion template saturation biopsy (TTSB) and conventional systematic transrectal TRUS-guided biopsy (SB).
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Barriers and enablers of active surveillance for prostate cancer – a qualitive study of clinicians BJU Int. (IF 4.5) Pub Date : 2023-09-11 Trent A Pattenden, Isaac A Thangasamy, Wee Loon Ong, Dhanika Samaranayke, Andrew Morton, Declan G Murphy, Susan Evans, Jeremy Millar, Venu Chalasani, Prem Rashid, Matthew Winter, Ian Vela, David Pryor, Stephen Mark, Stacy Loeb, Nathan Lawrentschuk, Elizabeth Pritchard
To identify and explore barriers to, and enablers of active surveillance (AS) in men with low-risk prostate cancer (LRPC), as perceived by prostate cancer clinicians.
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Prevalence of urolithiasis in China: A systematic review and meta-analysis BJU Int. (IF 4.5) Pub Date : 2023-09-11 Songsong Tan, Dongbo Yuan, Hao Su, Weihong Chen, Siqi Zhu, Bo Yan, Fa Sun, Kehua Jiang, Jianguo Zhu
China has a large population and complex geographical environment, which is lead to a large number of urolithiasis patients. However, there is a dearth of comprehensive investigations of urolithiasis prevalence. Consequently, This study aimed to estimate the pooled prevalence , as well as the spatial and temporal distribution, urolithiasis among subjects in China.
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Randomized trial of holmium laser vs. thulium laser vs. bipolar enucleation of large size prostate BJU Int. (IF 4.5) Pub Date : 2023-09-05 Ahmed M Shoma, Fady K. Ghobrial, Nasr El-Tabey, Ahmed S. El-Hefnawy, Hamdy A. El-Kappany
To compare the outcome and morbidity of B-TUEP and ThuLEP to HoLEP in treatment of large symptomatic benign prostatic obstruction (BPO) through non inferiority randomized controlled trial (NCT03916536).
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Real-time Estimation of Nephron Activity with a Linear Measurement System (RENAL-MS) Predicts Postoperative eGFR BJU Int. (IF 4.5) Pub Date : 2023-09-04 Jared P. Schober, Kevin B. Ginsburg, Alexander Kutikov, Eric Y Cho, Matt Loecher, David Strauss, Alberto Andres Castro Bigalli, Elizabeth Handorf, Mengying Deng M. Math, Jordan Anaokar, David YT. Chen, Richard E. Greenberg, Marc C. Smaldone, Rosalia Viterbo, Andres F. Correa, Robert G. Uzzo, Marshall Strother
Preoperative nuclear medicine renal scintigraphy (NMRS) is often used to predict estimated glomerular filtration (eGFR) after nephrectomy by estimating preoperative split renal function. We sought to determine whether a simple point-of-care measurement system estimating renal parenchymal volume using tools ubiquitously available could be used to replace NMRS in current clinical practice.
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Methodological Rigour in Preclinical Urology: a 14-year systematic review reporting research quality BJU Int. (IF 4.5) Pub Date : 2023-09-04 Seung Hyun Park, Se Bee Lee, Seoyeon Park, Eun Young Kim, Damiano Pizzol, Mike Trott, Yvonne Barnett, Ai Koyanagi, Louis Jacob, Pinar Soysal, Nicola Veronese, Simona Ippoliti, Ramy Abou Ghayda, Nannan Thirumavalavan, Adonis Hijaz, David Sheyn, Rachel Pope, Britt Conroy, Irina Jaeger, Gupta Shubham, Amihay Nevo, Petre Cristian Ilie, Seung Won Lee, Dong Keon Yon, Hyun Ho Han, Sung Hwi Hong, Jae Il Shin
The demand for methodological rigour in preclinical studies is increasing since the research reproducibility and transparency in the medico-scientific field are being questioned. As a result, we investigated the prevalence and the trends of essential study design elements in preclinical urological studies, as well as key factors which may improve methodological rigour.
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Reducing the risks of nuclear war – the role of health professionals BJU Int. (IF 4.5) Pub Date : 2023-09-05 Kamran Abbasi, Parveen Ali, Virginia Barbour, Kirsten Bibbins-Domingo, Marcel GM Olde Rikkert, Andy Haines, Ira Helfand, Richard Horton, Bob Mash, Arun Mitra, Carlos Monteiro, Elena N. Naumova, Eric J. Rubin, Tilman Ruff, Peush Sahni, James Tumwine, Paul Yonga, Chris Zielinski
In January, 2023, the Science and Security Board of the Bulletin of the Atomic Scientists moved the hands of the Doomsday Clock forward to 90 s before midnight, reflecting the growing risk of nuclear war.1 In August, 2022, the UN Secretary-General António Guterres warned that the world is now in “a time of nuclear danger not seen since the height of the Cold War.2 The danger has been underlined by
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Membranous urethral length and urinary incontinence following robot-assisted radical prostatectomy: a systematic review and meta-analysis BJU Int. (IF 4.5) Pub Date : 2023-09-04 Benjamin M. Mac Curtain, Diarmuid D. Sugrue, Wanyang Qian, Michael O'Callaghan, Niall F. Davis
To provide an update on the association between preoperative membranous urethral length (MUL) and postoperative urinary incontinence (UI) in men who undergo robot-assisted radical prostatectomy (RARP)/robot-assisted laparoscopic prostatectomy (RALP).
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Retrospective first-in-human use of the LithoVue™ Elite ureteroscope to measure intrarenal pressure BJU Int. (IF 4.5) Pub Date : 2023-09-04 Naeem Bhojani, Kyo Chul Koo, Kahina Bensaadi, Abdulghafour Halawani, Victor KF. Wong, Ben H. Chew
To report on our first-in-human experience using the LithoVue Elite™ ureteroscope (Boston Scientific Corp., Marlborough, MA, USA) to measure intrarenal pressure (IRP) during flexible ureteroscopy.
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In vivo ureteroscopic intrarenal pressures and clinical outcomes: a multi-institutional analysis of 120 consecutive patients BJU Int. (IF 4.5) Pub Date : 2023-09-01 Stefanie M. Croghan, Eoghan M. Cunnane, Sorcha O'Meara, Muheilan Muheilan, Connor V. Cunnane, Kenneth Patterson, Andreas Skolarikos, Bhaskar Somani, Gregory S. Jack, James C. Forde, Fergal J. O'Brien, Michael T. Walsh, Rustom P. Manecksha, Barry B. McGuire, Niall F. Davis
To evaluate the pressure range generated in the human renal collecting system during ureteroscopy (URS), in a large patient sample, and to investigate a relationship between intrarenal pressure (IRP) and outcome.
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‘Case of the Month’ from the Universitaetsklinik für Urologie, Bern, Switzerland: management of an unusual foreign body in the renal pelvis BJU Int. (IF 4.5) Pub Date : 2023-08-31 Karl G. Sommer, George N. Thalmann
Introduction Foreign bodies in the upper urinary tract (UUT) represent a rare, but well-documented phenomenon. Most foreign bodies in the kidney and UUT represent remnants of previous endourological surgery, especially since the advance of endourological procedures for the treatment of stone disease and UUT urothelial cancer. Hence, the incidence of iatrogenic foreign bodies in the UUT has increased
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Using prostate-specific membrane antigen positron-emission tomography to guide prostate biopsies and stage men at high-risk of prostate cancer BJU Int. (IF 4.5) Pub Date : 2023-08-24 Yves J.L. Bodar, Liselotte M.S. Boevé, Pim J. van Leeuwen, Phillippe C. Baars, Jakko A. Nieuwenhuijzen, Ernst P. van Haarst, Jorg R. Oddens, Maarten L. Donswijk, Luigi A. M. J. G. van Riel, Matthijs J. Scheltema, Dennie Meijer, N. Harry Hendrikse, Daniela E. Oprea-Lager, André N. Vis
To assess whether a diagnostic pathway in which prostate-specific membrane antigen (PSMA) positron-emission tomography (PET)/computed tomography (CT) is used as a single imaging modality is feasible to guide targeted biopsy and to detect clinically significant prostate cancer (csPCa) in biopsy-naïve men at high-risk of disease.
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Performance of magnetic resonance imaging-based prostate cancer risk calculators and decision strategies in two large European medical centres BJU Int. (IF 4.5) Pub Date : 2023-08-22 Petter Davik, Sebastiaan Remmers, Mattijs Elschot, Monique J. Roobol, Tone Frost Bathen, Helena Bertilsson
To compare the performance of currently available biopsy decision support tools incorporating magnetic resonance imaging (MRI) findings in predicting clinically significant prostate cancer (csPCa).
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The Dedicated Imaging Post-Prostatectomy for Enhanced Radiotherapy outcomes (DIPPER) trial protocol: a multicentre, randomised trial of salvage radiotherapy versus surveillance for low-risk biochemical recurrence after radical prostatectomy BJU Int. (IF 4.5) Pub Date : 2023-08-21 Matthew J. Roberts, Ciara Conduit, Ian D. Davis, Rachel M. Effeney, Scott Williams, Jarad M. Martin, Michael S. Hofman, George Hruby, Renu Eapen, Chris Gianacas, Nathan Papa, Richard De Abreu Lourenço, Haryana M. Dhillon, Ray Allen, Antoinette Fontela, Baldeep Kaur, Louise Emmett
Salvage radiation therapy (SRT) and surveillance for low-risk prostate-specific antigen (PSA) recurrence have competing risks and benefits. The efficacy of early SRT to the prostate bed with or without pelvic lymph nodes compared to surveillance in patients with PSA recurrence after radical prostatectomy and no identifiable recurrent disease evident on prostate specific membrane antigen-positron emission
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Versius robotic surgical system: case series of 18 robot-assisted radical prostatectomies BJU Int. (IF 4.5) Pub Date : 2023-08-21 Maurizio De Maria, Iacopo Meneghetti, Luca Mosillo, Chiara Catalano
To present the results of the first series of patients treated with robot-assisted radical prostatectomy (RARP) with the use of the Versius® Surgical System (CMR Surgical Ltd., Cambridge, UK). RARP has demonstrated better perioperative outcomes compared to open RP. However, RARP remains limited by platform availability and cost-effectiveness issues. The increasing competition from new robotic surgical
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Prostagram MRI in a Screening Population: PI-RADS or Likert? BJU Int. (IF 4.5) Pub Date : 2023-08-17 Nikhil Mayor, David Eldred-Evans, Henry Tam, Heminder Sokhi, Anwar R Padhani, Martin J Connor, Derek Price, Martin Gammon, Natalia Klimowska-Nassar, Paula Burak, Emily Day, Mathias Winkler, Francesca Fiorentino, Taimur Shah, Hashim Uddin Ahmed
The IP1-PROSTAGRAM study highlighted the potential of short biparametric “Prostagram” magnetic resonance imaging (bpMRI) scanning in screening for prostate cancer. We aimed to compare biopsy recommendation rates and accuracy of PI-RADSv2 with the Likert scale for detection of clinically significant and insignificant prostate cancer in men screened within IP1-PROSTAGRAM.
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Predicting obstruction risk using common ultrasonography parameters in paediatric hydronephrosis with machine learning BJU Int. (IF 4.5) Pub Date : 2023-08-18 Adree Khondker, Jethro C. C. Kwong, Margarita Chancy, Neeta D'Souza, Kellie Kim, Jin K. Kim, Lai Nam Tse, Michael Chua, Priyank Yadav, Lauren Erdman, John Weaver, Armando J. Lorenzo, Mandy Rickard
To sensitively predict the risk of renal obstruction on diuretic renography using routine reported ultrasonography (US) findings, coupled with machine learning approaches, and determine safe criteria for deferral of diuretic renography.
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A robot-assisted laparoscopic revision of an artificial urinary sphincter in a patient with spinal cord injury BJU Int. (IF 4.5) Pub Date : 2023-08-17 James Kovacic, Ashan Canagasingham, Ahmed Goolam, Amanda Chung
This step-by-step article demonstrates our approach to robot-assisted laparoscopic revision of a bladder neck sited artificial urinary sphincter (AUS) for a spinal cord injured patient. The bladder neck location of an AUS in the spinal cord injured demographic is ideal to minimise urethral complications and urinary tract infections, whilst the transabdominal approach reduces the risk of wound breakdown
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Localised non-metastatic sarcomatoid renal cell carcinoma: a 31-year externally verified study BJU Int. (IF 4.5) Pub Date : 2023-08-17 Kyle A. Blum, Andrew W. Silagy, Andrea Knezevic, Stanley Weng, Alan Wang, Roy Mano, Julian Marcon, Renzo G. DiNatale, Alejandro Sanchez, Satish Tickoo, Sounak Gupta, Robert Motzer, Naomi B. Haas, Se Eun Kim, Robert G. Uzzo, Jonathan A. Coleman, A. Ari Hakimi, Paul Russo
To evaluate post-nephrectomy outcomes and predictors of cancer-specific survival (CSS) between patients with localised sarcomatoid renal cell carcinoma (sRCC) and those with Grade 4 RCC (non-sRCC), as most sRCC research focuses on advanced or metastatic disease with limited studies analysing outcomes of patients with localised non-metastatic sRCC.
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Efficacy of RestoreX after prostatectomy: open-label phase of a randomised controlled trial BJU Int. (IF 4.5) Pub Date : 2023-08-14 Eric Chung
Penile traction therapy (PTT) has emerged as an attractive conservative treatment for Peyronie's disease (PD) and published international guidelines recommended Grade B, Level 2 Evidence regarding the use of PTT as an effective and safe treatment [1]. While published literature on PTT is often hampered by lack of treatment randomisation, small numbers of participants, and poor treatment compliance
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September's reviewers of the month BJU Int. (IF 4.5) Pub Date : 2023-08-15
Lotte Kaasgaard Jakobsen Lotte Kaasgaard Jakobsen, MD, PhD, FEBU, FEAPU, graduated from medical school at Aarhus University in 2005. She is currently employed as a Paediatric Urologist at Aarhus University Hospital, Denmark. Her PhD studies were conducted in the period 2014–2017 and were focused on the development of the urinary tract, with regards to contractile properties of the bladder wall at different
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Advances in Andrology and Stone Disease BJU Int. (IF 4.5) Pub Date : 2023-08-15
© istock.com/ John_Lerskau
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F-SHARP: a Phase I/II trial of focal salvage high-dose-rate brachytherapy for Radiorecurrent prostate cancer BJU Int. (IF 4.5) Pub Date : 2023-08-10 Abhishek A. Solanki, Ryan K. Yoo, William Adams, Elai Davicioni, Michael L. Mysz, Steven Shea, Gopal N. Gupta, Timothy Showalter, Aurelie Garant, Courtney Hentz, Ahmer Farooq, Kristin Baldea, William Small, Matthew M. Harkenrider
Intraprostatic local radiorecurrence (LRR) after definitive radiation is being increasingly identified due to the implementation of molecular positron emission tomography (PET)/computed tomography (CT) imaging for the evaluation of biochemical recurrence. Salvage high-dose rate (HDR) brachytherapy offers a promising local therapy option, with encouraging toxicity and efficacy based on early series
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Urinary function in female patients after traditional, organ-sparing and nerve-sparing radical cystectomy for bladder cancer: a systematic review and pooled analysis BJU Int. (IF 4.5) Pub Date : 2023-08-10 Ekaterina Laukhtina, Markus von Deimling, Benjamin Pradere, Takafumi Yanagisawa, Pawel Rajwa, Tatsushi Kawada, Fahad Quhal, Maximilian Pallauf, Alberto Bianchi, Muhammad Majdoub, Hadi Mostafaei, Reza Sari Motlagh, Keiichiro Mori, Dmitry Enikeev, Margit Fisch, Marco Moschini, David D'Andrea, Francesco Soria, Simone Albisinni, Harun Fajkovic, Michael Rink, Jeremy Yuen-Chun Teoh, Paolo Gontero, Shahrokh
To determine and summarize the available data on urinary, sexual, and health-related quality-of-life (HRQOL) outcomes after traditional radical cystectomy (RC), reproductive organ-preserving RC (ROPRC) and nerve-sparing RC (NSRC) for bladder cancer (BCa) in female patients.
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Assessment of eligibility criteria in renal cell carcinoma trials evaluating systemic therapy BJU Int. (IF 4.5) Pub Date : 2023-08-07 Daniela V. Castro, Sweta R. Prajapati, Matthew I. Feng, Elyse H. Chan, Kyle O. Lee, Trishita Paul, Ishaan Sehgal, Jalen Patel, Xiaochen Li, Zeynep B. Zengin, Hedyeh Ebrahimi, Ameish Govindarajan, Luis Meza, Benjamin D. Mercier, Neal S. Chawla, Nazli Dizman, Errol J. Philip, JoAnn Hsu, Cristiane D. Bergerot, Alex Chehrazi-Raffle, Adam Rock, Sandy Liu, Abhishek Tripathi, Tanya B. Dorff, Sumanta K. Pal
To characterise the restrictiveness of eligibility criteria in contemporary renal cell carcinoma (RCC) trials, using recommendations from the American Society of Clinical Oncology (ASCO)-Friends of Cancer Research (FCR) initiative.
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Oncological outcomes after attempted nerve-sparing radical prostatectomy (NSRP) in patients with high-risk prostate cancer are comparable to standard non-NSRP: a longitudinal long-term propensity-matched single-centre study BJU Int. (IF 4.5) Pub Date : 2023-08-07 Marc A. Furrer, Niranjan Sathianathen, Brigitta Gahl, Niall M. Corcoran, Christopher Soliman, Jose Antonio Rodriguez Calero, Gallus B. Ineichen, Miriam Gahl, Bernhard Kiss, George N. Thalmann
To assess the long-term safety of nerve-sparing radical prostatectomy (NSRP) in men with high-risk prostate cancer (PCa) by comparing survival outcomes, disease recurrence, the need for additional therapy, and perioperative outcomes of patients undergoing NSRP to those having non-NSRP.
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Scrotal point-of-care ultrasonography: a UK cross-speciality pilot training course evaluation BJU Int. (IF 4.5) Pub Date : 2023-08-04 Akash Sharma, Arjun Nathan, Marimo Rossiter, Alexander Ng, Aqua Asif, Marie Edison, Nikita Bhatt, Sinan Khadhouri, Nick Mani, Paul S. Sidhu, Simon Freeman, Julia Burkert, Dean Huang, Ailey McLeod, Daniel Kelly, Aishah Azam, Veeru Kasivisvanathan, Hannah Warren, Eleanor Zimmermann
Spermatic cord torsion is a time-critical surgical emergency, with suspected cases typically taken directly to theatre for scrotal exploration. However, only 20%–25% of patients who undergo scrotal exploration in this setting are found to have testicular torsion [1]. Therefore, the majority of patients undergo an unnecessary operation with associated surgical and anaesthetic risks, while increasing
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A pilot study of an organised population-based testing programme for prostate cancer BJU Int. (IF 4.5) Pub Date : 2023-07-31 Max Alterbeck, Erik Thimansson, Johan Bengtsson, Erik Baubeta, Sophia Zackrisson, Anetta Bolejko, Kevin Sandeman, Sigrid Carlsson, Thomas Jiborn, Anders Bjartell
To determine the feasibility of a digitally automated population-based programme for organised prostate cancer testing (OPT) in Southern Sweden.
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Haemorrhagic cystitis: a review of management strategies and emerging treatments BJU Int. (IF 4.5) Pub Date : 2023-07-28 Kevin D. Li, Charles P. Jones, Nizar Hakam, Bradley A. Erickson, Alex J. Vanni, Michael B. Chancellor, Benjamin N. Breyer
Haemorrhagic cystitis (HC) is characterised by persistent haematuria and lower urinary tract symptoms following radiotherapy or chemotherapy. Its pathogenesis is poorly understood but thought to be related to acrolein toxicity following chemotherapy or fibrosis/vascular remodelling after radiotherapy. There is no standard of care for patients with HC, although existing strategies including fulguration
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Post-prostatectomy anastomotic stenosis: systematic review and meta-analysis of endoscopic treatment BJU Int. (IF 4.5) Pub Date : 2023-07-28 Ophélie Delchet, Mikaïl Nourredine, Adolfo González Serrano, Nicolas Morel-Journel, Damien Carnicelli, Alain Ruffion, Paul Neuville
To perform a systematic review and meta-analysis of endoscopic procedures for treating vesico-urethral anastomotic stenosis (VUAS) after prostatectomy, as initial VUAS management remains unclear.
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Detrusor relaxing agents for neurogenic detrusor overactivity: a systematic review, meta-analysis and network meta-analysis BJU Int. (IF 4.5) Pub Date : 2023-07-27 Zhonghan Zhou, Xuesheng Wang, Xunhua Li, Limin Liao
To evaluate the evidence regarding the therapeutic benefits and safety of oral detrusor relaxing agents (DRAs) in treating neurogenic detrusor overactivity (NDO).
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Prognostic value of programmed death ligand-1 and programmed death-1 expression in patients with upper tract urothelial carcinoma BJU Int. (IF 4.5) Pub Date : 2023-07-24 Luca Campedel, Eva Compérat, Géraldine Cancel-Tassin, Justine Varinot, Christian Pfister, Clara Delcourt, Françoise Gobet, Mathieu Roumiguié, Pierre-Marie Patard, Gwendoline Daniel, Pierre Bigot, Julie Carrouget, Caroline Eymerit, Stéphane Larré, Priscilla Léon, Anne Durlach, Alain Ruffion, Emilien Seizilles de Mazancourt, Myriam Decaussin-Petrucci, Thomas Bessède, Cédric Lebacle, Sophie Ferlicot,
To evaluate the prognostic value of programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) expression in patients with upper tract urothelial carcinoma (UTUC).
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Open versus robot-assisted radical cystectomy: pentafecta and trifecta achievement comparison from a randomised controlled trial BJU Int. (IF 4.5) Pub Date : 2023-07-20 Riccardo Mastroianni, Gabriele Tuderti, Mariaconsiglia Ferriero, Umberto Anceschi, Alfredo Maria Bove, Aldo Brassetti, Leonardo Misuraca, Simone D'Annunzio, Salvatore Guaglianone, Michele Gallucci, Giuseppe Simone
To compare University of Southern California (USC) Institute of Urology pentafecta and trifecta achievement comparing open radical cystectomy (ORC) vs robot-assisted RC (RARC) with totally intracorporeal urinary diversion (iUD) from a randomised controlled trial (RCT).
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Intraoperative ultrasonography (IOUS)-guided vs conventional laparoscopic nephrectomy: a randomised control trial BJU Int. (IF 4.5) Pub Date : 2023-07-20 Manoj K. Das, Gorrepati Rohith, Swarnendu Mandal, Abhay Singh Gaur, Prasant Nayak, Santosh Kumaraswamy, Vivek Tarigopula, Dheeraj Kumar Dheroo, Sambit Tripathy
To assess the efficacy of routine use of intraoperative ultrasonography (IOUS) in improving perioperative outcomes in patients undergoing IOUS-guided laparoscopic nephrectomy (IOUS-LN) and conventional laparoscopic nephrectomy (C-LN).
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ISUP Gleason Grade Groups stratify outcomes in the CHHiP phase 3 prostate radiotherapy trial BJU Int. (IF 4.5) Pub Date : 2023-07-18 David Dearnaley, Clare L Griffin, Pedro Silva, Anna Wilkins, Christine Stuttle, Isabel Syndikus, Shama Hassan, Julia Pugh, Clare Cruickshank, Emma Hall, Catherine M Corbishley
To compare the results of Gleason Grade Group (GGG) classification following central pathology (CP) review with previous local pathology (LP) assessment and examine the difference in using overall or worst GGG in a large patient cohort treated with radiotherapy and short-course hormonal therapy (s-cHT).
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Robot-assisted versus three-dimensional laparoscopic radical prostatectomy: 12-month outcomes of a randomised controlled trial BJU Int. (IF 4.5) Pub Date : 2023-07-17 Henry Haapiainen, Teemu J. Murtola, Juha Koskimäki, Jarno Riikonen, Tomi Pakarainen, Caelán M. Haney, Mika Raitanen, Antti Kaipia
To compare functional and oncological outcomes of robot-assisted laparoscopic prostatectomy (RALP) to three-dimensional laparoscopic radical prostatectomy (3D-LRP) at 12 months after surgery.
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Poly(adenosine diphosphate-ribose) polymerase inhibitor combinations in first-line metastatic castrate-resistant prostate cancer setting: a systematic review and meta-analysis BJU Int. (IF 4.5) Pub Date : 2023-07-17 Rashid K. Sayyid, Zachary Klaassen, Alejandro Berlin, Soumyajit Roy, Leonardo R. Brandão, Rui Bernardino, Julian Chavarriaga, Di Maria Jiang, Daniel E. Spratt, Neil E. Fleshner, Christopher J.D. Wallis
To compare radiographic progression-free survival (rPFS), overall survival (OS), and treatment-emergent adverse events (TEAEs) among patients with metastatic castrate-resistant prostate cancer (mCRPC) receiving a combination of first-line poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPi) plus androgen receptor axis-targeted agents (ARAT) vs placebo/ARAT.
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Salvage holmium laser enucleation of the prostate after previous interventions: a systematic review BJU Int. (IF 4.5) Pub Date : 2023-07-17 Panagiotis Kallidonis, Theodoros Spinos, Angelis Peteinaris, Bhaskar Somani, Evangelos Liatsikos
To investigate the feasibility, safety and efficacy of holmium laser enucleation of the prostate (HoLEP) in the re-treatment setting (salvage HoLEP) and compare it to the primary HoLEP procedure that is commonly used for the treatment of benign prostate hyperplasia (BPH).
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Impact of age >70 years on oncological outcomes in patients with non-muscle-invasive bladder cancer treated with Bacillus Calmette–Guérin BJU Int. (IF 4.5) Pub Date : 2023-07-13 Roberto Contieri, Valentina Grajales, Wei Shen Tan, Alberto Martini, Akshay Sood, Patrick Hensley, Kelly Bree, Niyati Lobo, Graciela M. Nogueras-Gonzalez, Charles C. Guo, Neema Navai, Colin P. Dinney, Ashish M. Kamat
To evaluate the impact of age on oncological outcomes in a large contemporary cohort of patients with non-muscle-invasive bladder cancer (NMIBC) treated with adequate Bacillus Calmette–Guérin (BCG).
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Implementation and yield of upfront genomic profiling in a clinical prostate cancer diagnostic pathway BJU Int. (IF 4.5) Pub Date : 2023-07-10 Charlie Massie, Vincent J. Gnanapragasam, Tristan Barrett, Anne Warren, Shubha Anand, Alexandra Keates, Simon Pacey
Recent landmark studies have shown a survival benefit from using genomic profiling to guide targeted personalized therapy in men with metastatic castrate-refractory prostate cancer (mCRPC) [1]. However, the point at which genomic profiles should be acquired in the prostate cancer pathway remains unclear. Primary high-grade and/or locally advanced prostate cancer has a significant relapse rate despite
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Diagnosis, treatment, and survival from kidney cancer: real-world National Health Service England data between 2013 and 2019 BJU Int. (IF 4.5) Pub Date : 2023-07-12 Samantha Conroy, James W.F. Catto, Axel Bex, Janet E. Brown, Jon Cartledge, Alison Fielding, Rob J. Jones, Vincent Khoo, David Nicol, Grant D. Stewart, Mark Sullivan, Maxine G.B. Tran, Rose Woodward, Marcus G. Cumberbatch
To report the NHS Digital (NHSD) data for patients diagnosed with kidney cancer (KC) in England. We explore the incidence, route to diagnosis (RTD), treatment, and survival patterns from 2013 to 2019.
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Mesorectal nodal metastasis with seminal vesicle invasion in biochemically recurrent prostate cancer BJU Int. (IF 4.5) Pub Date : 2023-07-11 Rashid K. Sayyid, Rui Bernardino, Zizo Al-Daqqaq, Raj Tiwari, Jessica Cockburn, Shagana Vijayakanthan, Ricardo Leão, Yazan Qaoud, Mohamad Baker Berjaoui, Ur Metser, Alejandro Berlin, Neil E. Fleshner
To determine the prevalence and predictors of mesorectal lymph node (MLN) metastases on prostate-specific membrane antigen (PSMA)-based positron emission tomography/computed tomography (PET/CT) in patients with biochemically recurrent prostate cancer (PCa) following radical therapy.
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Nephrectomy for kidney tumour increases the risk of de novo arterial hypertension BJU Int. (IF 4.5) Pub Date : 2023-07-11 Pierre Bigot, Jean-Christophe Bernhard, Zine-Eddine Khene, Charles Dariane, Souhil Lebdai, Nicolas Doumerc, François Xavier Nouhaud, Idir Ouzaid, Patrick Saulnier, Arnaud Méjean, Morgan Roupret, Karim Bensalah
To evaluate prospectively the effects of surgical excision of renal tumours on blood pressure (BP).
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The immune-related adverse events paradox in locally advanced or metastatic urothelial cancer after atezolizumab immunotherapy: analysis of individual patient data from IMvigor210 and IMvigor211 trials BJU Int. (IF 4.5) Pub Date : 2023-07-09 Daniele Robesti, Luigi Nocera, Federico Belladelli, Julianne G. Schultz, Giuseppe Fallara, Laura Marandino, Daniele Raggi, Francesco Montorsi, Pavlos Msaouel, Andrea Necchi, Alberto Martini
To investigate the association between immune-related adverse events (irAEs) and oncological outcomes in patients with advanced urothelial cancer receiving immune checkpoint inhibitors (ICIs), and whether the administration of systemic corticosteroids diminishes therapeutic impact.
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Prostate cancer outcomes following whole-gland and focal high-intensity focused ultrasound BJU Int. (IF 4.5) Pub Date : 2023-07-08 Matthew G. Parry, Arunan Sujenthiran, Julie Nossiter, Melanie Morris, Brendan Berry, Arjun Nathan, Ajay Aggarwal, Heather Payne, Jan van der Meulen, Noel W. Clarke
To report the 5-year failure-free survival (FFS) following high-intensity focused ultrasound (HIFU).
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Intrarenal pressures during flexible ureteroscopy: an insight into safer endourology BJU Int. (IF 4.5) Pub Date : 2023-07-07 Anne Hong, Cliodhna Browne, Greg Jack, Damien Bolton
To assess intrarenal pressures (IRPs) and complication rates after flexible ureteroscopy (fURS), and to assess factors that contribute to raised IRPs and postoperative complications.
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Personalised indocyanine-guided lymphadenectomy for prostate cancer: a randomised clinical trial BJU Int. (IF 4.5) Pub Date : 2023-07-06 Pedro de Pablos-Rodríguez, Francesco Claps, Giacomo Rebez, Natalia Vidal Crespo, Álvaro Gómez-Ferrer, Juan Manuel Mascarós, Argimiro Collado Serra, Ana Caltrava Fons, José Rubio-Briones, Juan Casanova Ramon Borja, Miguel Ramírez Backhaus
To study the safety and efficacy of a personalised indocyanine-guided pelvic lymph node dissection (PLND) against extended PLND (ePLND) during radical prostatectomy (RP).
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Aligning germline and somatic mutations in prostate cancer. Are genetics changing practice? BJU Int. (IF 4.5) Pub Date : 2023-07-06 Olivier Cussenot, Geraldine Cancel-Tassin, Srinivasa R. Rao, Dan J. Woodcock, Alastair D. Lamb, Ian G. Mills, Freddie C. Hamdy
To review the current status of germline and somatic (tumour) genetic testing for prostate cancer (PCa), and its relevance for clinical practice.
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Bladder cancer grading using the four-tier combination of the World Health Organization (WHO) 1973 and WHO 2004 classifications BJU Int. (IF 4.5) Pub Date : 2023-07-06 Staffan Jahnson, Georg Jancke, Hans Olsson, Firas Aljabery
To investigate the impact of grading in urothelial bladder cancer (UBC) stages Ta and T1, comparing the World Health Organization (WHO) grading classifications of 1973 (WHO73) and 2004 (WHO04) and a combination of these (WHO73/04).
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Guideline of guidelines: follow-up after orchidectomy for clinical stage 1 testicular cancer BJU Int. (IF 4.5) Pub Date : 2023-07-06 Julian Chavarriaga, Adam Bobrowski, Robert J. Hamilton
Several medical organisations have developed evidence-based guidelines for the diagnosis, management, and follow-up of testicular cancer. This article aimed to review, compare, and summarise the most updated international guidelines and surveillance protocols for clinical stage 1 (CS1) testicular cancer. We reviewed a total of 46 articles on proposed follow-up strategies for testicular cancer, and
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Parenchymal volume analysis to assess longitudinal functional decline following partial nephrectomy BJU Int. (IF 4.5) Pub Date : 2023-07-06 Carlos Munoz-Lopez, Kieran Lewis, Worapat Attawettayanon, Yosuke Yasuda, João Pedro Emrich Accioly, Nityam Rathi, Zaeem Lone, Melissa Boumitri, Rebecca A. Campbell, Andrew Wood, Jihad Kaouk, Georges-Pascal Haber, Mohamad Eltemamy, Venkatesh Krishnamurthi, Robert Abouassaly, Samuel Haywood, Christopher Weight, Steven C. Campbell
To identify factors associated with longitudinal ipsilateral functional decline after partial nephrectomy (PN).
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Adjustable transobturator male system (ATOMS) for stress urinary incontinence: the evidence is mounting BJU Int. (IF 4.5) Pub Date : 2023-07-06 Mohit Bajaj, Chris Frampton, Giovanni Losco, Andre Westenberg
To evaluate the New Zealand clinical experience with the adjustable transobturator male system (ATOMS), a novel continence device in the management of all degrees of stress urinary incontinence (SUI), focusing on efficacy and safety outcomes.
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Estimated glomerular filtration rate from the renal hypothermia trial: clinical implications BJU Int. (IF 4.5) Pub Date : 2023-07-06 Francis Lemire, Dean A. Fergusson, Greg Knoll, Christopher Morash, Luke T. Lavallée, Ranjeeta Mallick, Antonio Finelli, Anil Kapoor, Frédéric Pouliot, Jonathan Izawa, Ricardo Rendon, Ilias Cagiannos, Rodney H. Breau
To assess if estimated glomerular filtration rate (eGFR) can replace measured GFR (mGFR) in partial nephrectomy (PN) trials, using data from a randomised clinical trial.
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Mucomucosal anastomotic non-transecting augmentation (MANTA) urethroplasty: a ventral modification for obliterative strictures BJU Int. (IF 4.5) Pub Date : 2023-07-06 Phillip Marks, Roland Dahlem, Florian Janisch, Jakob Klemm, Lennart Kühnke, Frederik König, Liucheng Ding, Silke Riechardt, Margit Fisch, Malte W. Vetterlein
To present a surgical modification for the repair of bulbar urethral strictures containing short, highly obliterative segments and report on long-term objective and patient-reported outcomes.
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The impact of body mass index on oncological and surgical outcomes of patients undergoing nephrectomy: a systematic review and meta-analysis BJU Int. (IF 4.5) Pub Date : 2023-07-04 Chloe S.H. Ong, Terence Y.X. Law, Alex Mok, Kenny S.C. Ho, Ziting Wang, Edmund Chiong, Ho Yee Tiong, Jeremy Y.C. Teoh
To perform a systematic review and meta-analysis to evaluate the impact of body mass index (BMI) on oncological (primary) and surgical (secondary) outcomes of patients who underwent nephrectomy, as obesity or high BMI is a known risk factor for renal cell carcinoma (RCC) and predictor of poorer outcomes.
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Morphometric variations of Cajal-like cells are associated with pelviureteric junction obstruction in children. BJU Int. (IF 4.5) Pub Date : 2023-07-04 Udagedara Mudiyanselage Jayami Eshana Samaranayake,Yasith Mathangasinghe,Malik Samarasinghe,Ananda Kumara Lamahewage,Udari Apsara Liyanage,Nirmala Dushyanthi Sirisena,Mannikawadumesthri Vipula Chandu de Silva,Ajith Peiris Malalasekera
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Outcomes of transecting versus non-transecting urethroplasty for bulbar urethral stricture: a meta-analysis BJU Int. (IF 4.5) Pub Date : 2023-07-04 Maciej Oszczudlowski, Christian Yepes, Jakub Dobruch, Francisco E. Martins
To assess outcomes of transecting vs non-transecting urethroplasty for bulbar urethral stricture in terms of stricture recurrence rate, sexual dysfunction, and patient-reported outcome measures (PROMs) related to lower urinary tract (LUT) function.
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Robot-assisted radical cystectomy with intracorporeal urinary diversion: a Danish 11-year series BJU Int. (IF 4.5) Pub Date : 2023-07-03 Marie-Louise Vrang, Peter Busch Østergren, Mikkel Mejlgaard Fode, Michael Vangedal, Gitte Wrist Lam
To evaluate the oncological and perioperative outcomes from a large, single-centre, robot-assisted radical cystectomy (RARC) cohort performed with intracorporeal urinary diversion (ICUD).