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Salvage low‐dose vs high‐dose brachytherapy for radio‐recurrent prostate cancer BJU Int. (IF 3.7) Pub Date : 2025-02-11 Shaoqin Xie, Jianjiang Liu, Bin Shen, Huali Xu, Jiajing Ni
ObjectiveTo summarise the efficacy and toxicity of salvage low‐dose‐rate brachytherapy (LDR‐BT) and compare these findings with the published data on salvage high‐dose‐rate brachytherapy (HDR‐BT).MethodsWe reviewed PubMed and EMBASE for studies published up to May 2024, mainly focusing on recurrence‐free survival (RFS) with salvage LDR‐BT across subgroups. We also compared RFS and adverse events with
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Characterisation of vent designs in flexible and navigable suction ureteric access sheaths BJU Int. (IF 3.7) Pub Date : 2025-02-06 Richard Menzies‐Wilson, Jessica Williams, Candace Rhodes, Alycia Abbott, Thijs Ruiken, Benjamin Turney
ObjectivesTo evaluate the different vent designs in three commercially available flexible and navigable suction (FANS) access sheaths—ClearPetra® (Well lead, Guangzhou, China), Elephant II (YIGAOMedical, Hangzhou, China) and Tuohy‐Borst FANS access sheath (Seplou, Zhejiang, China)—and quantify the effects these differing designs have on the control of suction.MethodsWe conducted benchtop experiments
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Refining partial gland ablation for localised prostate cancer: the FALCON project BJU Int. (IF 3.7) Pub Date : 2025-02-04 Lara Rodriguez-Sanchez, Xavier Cathelineau, Theo M. de Reijke, Phillip Stricker, Mark Emberton, Anna Lantz, Bernardino Miñana López, Jose Luis Dominguez-Escrig, Fernando J. Bianco, Georg Salomon, Aiman Haider, Anita Mitra, Alberto Bossi, Eva Compérat, Robert Reiter, Pilar Laguna, Gaelle Fiard, Luca Lunelli, George R. Schade, Peter Ka-Fung Chiu, Petr Macek, Veeru Kasivisvanathan, Jean J.M.C.H. Rosette
To provide a contemporary statement on focal therapy (FT) for localised prostate cancer (PCa) from an international and diverse group of physicians treating localised PCa, with the aim of overcoming the limitations of previous consensus statements, which were restricted to early adopters, and to offer direction regarding the various aspects of FT application that are currently not well defined.
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Comparison of female and male prostate glands BJU Int. (IF 3.7) Pub Date : 2025-02-05 Britt Haller, James Brock, Eric Chung, Helen E. O’Connell
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Recommendation on the use of protective eyewear in endourological laser procedures BJU Int. (IF 3.7) Pub Date : 2025-02-01 Tom Lister, Stan Batchelor, Mike Regan, Jason Britton, Hari Ratan, Feras Al-Jaafari, Jake Patterson
This work examines the current evidence available regarding the risks of eye injury in endourology laser environments with the aim of providing a consensus recommendation on the appropriate use of protective eyewear.
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Global comparison of research ethical review protocols: insights from an international research collaborative BJU Int. (IF 3.7) Pub Date : 2025-01-31 Bing Jie Chow, Alexander Light, Arjun Nathan, Loic Baekelandt, Gautier Marcq, Stefanie Croghan, Fortis Gaba, Francesco Esperto, Luca Orecchia, Carlos Toribio-Vázquez, Juan Gómez Rivas, Adrian Chi-Heng Fung, Kaleab Habtemichael Gebreselassie, Eduardo Felicio, Aria Danurdoro, Nikolaos Pyrgidis, Vukovic Marko, Jan Svihra, Mohamed Javid, Andrés Salas, Tran Trung Thanh, Cameron Alexander, Nikita Bhatt,
Scientific ethical review is a cornerstone of conducting medical research. It aims to ensure human subject research is conducted in a manner that safeguards and respects participants’ rights and well-being. Research ethics committees (RECs) or institutional review boards (IRBs) are responsible for ethical evaluations before approval. This entails assessing potential risks and benefits associated with
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Extraperitoneal single‐site robot‐assisted radical prostatectomy with extended pelvic lymph node dissection: technique and experience BJU Int. (IF 3.7) Pub Date : 2025-01-30 Yubo Wang, Mingzhao Li, Kai Yao, Zhuyinjun Zong, Yifan Chang, Yongda Liu, Chao Cai, Fadi Mousa Al Kalailah, Shancheng Ren, Guohua Zeng, Di Gu
Introduction For patients with locally advanced or high-risk localised prostate cancer who require lymph node dissection (LND), guidelines recommend an extended pelvic LND (ePLND). Such an extensive dissection ensures accurate staging information for most patients [1]. Advancements in surgical instrumentation and optimisation of surgical techniques could potentially empower surgeons to perform an ePLND
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The 5‐year results of the Stratified Cancer Active Surveillance programme for men with prostate cancer BJU Int. (IF 3.7) Pub Date : 2025-01-30 Vincent J. Gnanapragasam, Alexandra Keates, Artitaya Lophatananon, Vineetha Thankapannair
ObjectivesTo report 5‐year outcomes from the STRATified CANcer Surveillance (STRATCANS) programme based on progression risks using National Institute for Health and Clinical Excellence (NICE) Cambridge Prognostic Group (CPG) at diagnosis, prostate specific antigen density and magnetic resonance imaging (MRI) visibility.Patients and MethodsMen with CPG1 and CPG2 disease selecting active surveillance
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Growth kinetics of renal tumours during pregnancy in patients with hereditary renal cancer syndromes BJU Int. (IF 3.7) Pub Date : 2025-01-29 Nityam Rathi, Rabindra Gautam, Jason Hyman, Daniel Nethala, W. Marston Linehan, Mark W. Ball, Sandeep Gurram
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Tumour size is associated with growth rates of >0.5 cm/year and delayed intervention in small renal masses in patients on active surveillance BJU Int. (IF 3.7) Pub Date : 2025-01-28 Maximilian Pallauf, Michael Rezaee, Roy Elias, Tina Wlajnitz, Sean A. Fletcher, Joseph Cheaib, Khalid Alkhatib, Peter Chang, Andrew A. Wagner, James M. McKiernan, Mohamad E. Allaf, Phillip M. Pierorazio, Nirmish Singla
ObjectiveTo evaluate the association between tumour size and the growth rate (GR) of small renal masses (SRMs) in patients managed by active surveillance (AS).Materials and MethodsWe queried the prospective, multi‐institutional Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) registry for patients on AS with an imaging interval of ≥6 months, identifying 456 patients. We tracked
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Improving environmental sustainability in urology as a resident BJU Int. (IF 3.7) Pub Date : 2025-01-28 Bushra Abdelqader, Archie McGrath, Pinky Kotecha, John S McGrath, Joseph John
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Robotic surgery for paediatric neurogenic lower urinary tract dysfunction: a systematic review BJU Int. (IF 3.7) Pub Date : 2025-01-28 Ihtisham Ahmad, Dheidan Alshammari, Priyank Yadav, Michael Chua, Margarita Chancy, Mohd S. Ansari, Mohan S. Gundeti
ObjectiveTo evaluate in a systematic review the outcomes, benefits, and limitations of robot‐assisted surgeries for paediatric neurogenic lower urinary tract dysfunction (LUTD), as robot‐assisted techniques have emerged as a potential alternative, offering enhanced precision, dexterity, and visualisation.MethodsThis review was registered in the International Prospective Register of Systematic Reviews
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Fluid intake and recurrence and progression risk of patients with non‐muscle‐invasive bladder cancer BJU Int. (IF 3.7) Pub Date : 2025-01-25 Ivy Beeren, Hilde Meijer, Antoine G. van der Heijden, Katja K.H. Aben, J. Alfred Witjes, Lambertus A.L.M. Kiemeney, Alina Vrieling
ObjectivesTo evaluate the association of pre‐ and post‐diagnosis fluid intake with non‐muscle‐invasive bladder cancer (NMIBC) recurrence and progression risk.Patients and MethodsData were used from the multicentre prospective cohort study UroLife. Participants reported pre‐diagnosis fluid intake at 6 weeks (food frequency questionnaire [FFQ]) (n = 1322) and post‐diagnosis fluid intake at 3 and 15 months
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Comparing open and video endoscopic lymphadenectomy for penile cancer: a systematic review and meta‐analysis of prospective studies BJU Int. (IF 3.7) Pub Date : 2025-01-25 Caio Vinícius Suartz, Richard Dobrucki de Lima, Luiza Rafih Abud, Pedro Henrique Souza Brito, Ketlyn Assunção Galhardo, Thalita Bento Talizin, André Lopes Salazar, Fernando Korkes, Giuliano Guglielmetti, Stênio de Cássio Zequi, Leopoldo Alves Ribeiro‐Filho, Paul Toren, Michele Lodde
ObjectiveTo conduct the first meta‐analysis using only prospective studies to evaluate whether video endoscopic inguinal lymphadenectomy (VEIL) offers advantages in perioperative outcomes compared to open IL (OIL) in patients with penile cancer.MethodsA systematic review with meta‐analysis was conducted across multiple databases, including Cochrane Central Register of Controlled Trials (CENTRAL), the
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Metabolic syndrome is associated with postoperative complications after holmium laser enucleation of the prostate BJU Int. (IF 3.7) Pub Date : 2025-01-24 Victoria S. Edmonds, Daniel J. Heidenberg, Connor Mayes, Carolyn Mead‐Harvey, Mitchell R. Humphreys
ObjectivesTo compare postoperative complication rates of patients with metabolic syndrome (MetS) with patients without MetS after holmium laser enucleation of the prostate (HoLEP) for management of benign prostatic hyperplasia (BPH).Patients and MethodsWe retrospectively reviewed patients aged >40 years who underwent HoLEP at our institution from 2007 to 2022. Criteria for MetS were diagnoses of at
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Re‐defining the interpretation of 24‐h urine studies for stone formers BJU Int. (IF 3.7) Pub Date : 2025-01-23 Wilson Sui, Heiko Yang, Maria C. Velasquez, Marshall L. Stoller, Thomas Chi
ObjectivesTo identify associations between 24‐h urine abnormalities and clinical risk factors for recurrent stone formers.Patients and methodsThe Registry for Stones of the Kidney and Ureter was queried for all patients who underwent 24‐h urine studies. Patients were categorised by the number of clinical risk factors for recurrent stone disease. Stone recurrence was calculated by stone events per person‐year
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Immunotherapy‐based neoadjuvant treatment and complication rates after radical cystectomy BJU Int. (IF 3.7) Pub Date : 2025-01-23 Reuben Ben‐David, Francesco Pellegrino, Reza Mehrazin, Joel Thomas, Jack Geduldig, Sarah Lidagoster, Evan B. Garden, Kyrollis Attalla, Ahmed Eraky, Paolo Zaurito, Marco Moschini, Alberto Briganti, Francesco Montorsi, John P. Sfakianos, Peter Wiklund
ObjectiveTo assess 30‐ and 90‐day postoperative complication rates in patients who underwent robot‐assisted radical cystectomy (RARC) after receiving novel immunotherapy‐based neoadjuvant treatment.MethodsA bi‐centre analysis was conducted in patients who underwent RARC with intracorporeal urinary diversion and who received an immunotherapy‐based neoadjuvant regimen between 2017 and 2023. Complications
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Randomised controlled feasibility trial of retroperitoneal vs transperitoneal robot‐assisted partial nephrectomy: the ROPARN study BJU Int. (IF 3.7) Pub Date : 2025-01-22 Sebastian Kälble, Simon U. Engelmann, Hannah Schrutz, Florian Zeman, Emily Rinderknecht, Maximilian Haas, Christoph Pickl, Christopher Goßler, Yushan Yang, Stefan Denzinger, Maximilian Burger, Johannes Bründl, Roman Mayr
ObjectivesTo assess the feasibility of trial recruitment and confirm that retroperitoneal robotic partial nephrectomy (RRPN) has the same oncological efficacy as transperitoneal robotic partial nephrectomy (TRPN), with time advantages and less peri‐operative morbidity, in a randomised controlled trial (RCT).Patients and MethodsThe study was designed as a single‐centre, open‐label, feasibility RCT.
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Association of prostate‐specific antigen density with prostate cancer mortality after a benign systematic prostate biopsy result BJU Int. (IF 3.7) Pub Date : 2025-01-22 Juho Pylväläinen, Kirsi Talala, Jani Raitanen, Antti Rannikko, Anssi Auvinen
ObjectiveTo assess the association between prostate‐specific antigen (PSA) density (PSAD) and prostate cancer mortality after a benign result on systematic transrectal ultrasonography (TRUS)‐guided prostate biopsy.Patients and MethodsThis retrospective study used data from the Finnish Randomised Study of Screening for Prostate Cancer (FinRSPC) collected between 1996 and 2020. We identified men aged
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Rethinking routine histological analysis of transurethral resection of the prostate tissue samples: cost, relevance, and patient impact BJU Int. (IF 3.7) Pub Date : 2025-01-21 Aikaterini Eleftheriadou, James Aljoe, Matthew Deacon, Vishwas Iyer, Nimalan Arumainayagam
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February's reviewers of the month BJU Int. (IF 3.7) Pub Date : 2025-01-21
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Outcomes of prostate cancer treatments BJU Int. (IF 3.7) Pub Date : 2025-01-21
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The COVID‐19 pandemic and Urology – reflecting on successful initiatives and lessons in Australia BJU Int. (IF 3.7) Pub Date : 2025-01-20 Jennifer Xu, Matthew Alberto, Dixon Woon, Damien Bolton, Joseph Ischia
ObjectivesTo summarise the impact of the coronavirus disease 2019 (COVID‐19) pandemic on urological practice globally with a focus on Australian initiatives, as the pandemic resulted in radical changes in healthcare infrastructure and policies.MethodsWe conducted a literature review of the Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE) and Web of
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Response to neoadjuvant chemotherapy leads to better survival outcomes in upper tract urothelial carcinoma BJU Int. (IF 3.7) Pub Date : 2025-01-18 Alice Yu, Patrick J. Hensley, Heather L. Huelster, Austin Martin, Aaron Potrezke, Jonathan Pham, Jay D. Raman, Maximilian Pallauf, Nirmish Singla, Andrew Katims, Jonathan Coleman, Vitaly Margulis, Surena F. Matin, Philippe E. Spiess
ObjectivesTo evaluate the benefit of neoadjuvant chemotherapy (NAC) for patients with high‐risk upper tract urothelial carcinoma (UTUC) using a large, well‐curated multi‐institutional database.Patients and MethodsThis study was a multi‐institutional retrospective analysis conducted by the UTUC Collaborative Network (UCAN), combining data from 2276 patients with UTUC who underwent radical nephroureterectomy
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Robotic surgery: turning proficiency to independence in modern times BJU Int. (IF 3.7) Pub Date : 2025-01-18 Kamran Haq, Bhavan Prasad Rai
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Outcomes after cystectomy in Australian rural and metropolitan hospitals by intensive care admissions BJU Int. (IF 3.7) Pub Date : 2025-01-17 Jessica A. Paynter, Zakary Doherty, Kirby R. Qin, David Pilcher, Janelle Brennan
ObjectivesTo examine demographics and in‐hospital outcomes for patients admitted to Australian intensive care units (ICUs) following cystectomy of the urinary bladder. Additionally, to compare outcomes between metropolitan and rural hospitals.Patients and MethodsA retrospective cohort analysis was undertaken of all adult patients admitted to participating Australian ICUs (Australian and New Zealand
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String theory: placement of locking ligation clips in sliding renorrhaphy for partial nephrectomy BJU Int. (IF 3.7) Pub Date : 2025-01-14 Victor Yu, Sarah Lorger, Mark Broe, Ruban Thanigasalam, Scott Leslie, Louie Tolentino, Nariman Ahmadi, George McClintock
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Patient‐side performance metrics in robotic surgery: international Delphi‐based consensus from the Junior European Association of Urology Robotic Section/Young Academic Urologists BJU Int. (IF 3.7) Pub Date : 2025-01-14 Christoph Würnschimmel, Marco Paciotti, Mike Wenzel, Carlo Andrea Bravi, Ruben De Groote, Paolo Dell'Oglio, Fabrizio Di Maida, Marcio Covas Moschovas, Federico Piramide, Filippo Turri, Iulia Andras, Gabriele Sorce, Nikolaos Liakos, Anthony Gallagher, Domenico Veneziano, Ton Brouwers, Evangelos Liatsikos, Alberto Breda, Alessandro Larcher
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Tattoos as a risk factor for bladder cancer: a call for cohort studies BJU Int. (IF 3.7) Pub Date : 2025-01-14 Nicolas Kluger, Sebastiaan A.S. van der van der Bent
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Urologists and social media: pitfalls and perils and what to think about before hitting ‘send’ BJU Int. (IF 3.7) Pub Date : 2025-01-13 Helen W Cui, John Reynard
ObjectiveTo summarise current guidelines from professional bodies relevant to urologists on social media, and to discusses a range of risks associated with social media use. These include the risk of a fitness to practise investigation, breaking the law, loss of employment, and personal risk in the form of harassment and doxxing.MethodsReview of guidelines and recommendations published by professional
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Spatial distribution and subtype‐specific expression patterns of Nectin‐4 in muscle‐invasive bladder cancer BJU Int. (IF 3.7) Pub Date : 2025-01-13 Csilla Olah, Lara Sichward, Boris Hadaschik, Christopher Darr, Viktor Grünwald, Ulrich Krafft, Barbara T. Grünwald, Osama Mahmoud, Mulham Al‐Nader, Peter Nyirady, Henning Reis, Tibor Szarvas
ObjectiveTo investigate the expression patterns of Nectin‐4, the target molecule of the antibody‐drug conjugate enfortumab vedotin (EV), in relation to histological and molecular subtypes of urothelial bladder cancer (UBC).Patients and MethodsWe assessed the protein expression patterns of Nectin‐4 in a spatially organised tissue microarray containing 1386 tissue cores from 314 consecutive patients
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Gemcitabine and docetaxel for high-risk non-muscle-invasive bladder cancer: EuroGemDoce group results BJU Int. (IF 3.7) Pub Date : 2025-01-11 Pietro Scilipoti, Mattia Longoni, Mario de Angelis, Paolo Zaurito, Albane Massiet, Daniele Dutto, Francesco Soria, Mario Álvarez-Maestro, Alfredo Aguilera Bazán, Benjamin Pradere, Tobias Klatte, Roberto Contieri, Rodolfo Hurle, Wojciech Krajewski, José Daniel Subiela, Renate Pichler, Aleksandra Szostek, Gautier Marcq, José Luis Rodríguez Elena, Javier Aranda, Paolo Gontero, Morgan Rouprêt, Shahrokh
To evaluate the oncological efficacy and safety of sequential intravesical gemcitabine/docetaxel (Gem/Doce) therapy in a European cohort of patients with high-risk and very-high-risk non-muscle-invasive bladder cancer (NMIBC) after previous Bacillus Calmette–Guérin (BCG) treatment.
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Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial BJU Int. (IF 3.7) Pub Date : 2025-01-11 Meryam El Issaoui, Marlene Elmelund, Niels Klarskov
ObjectivesTo evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder.Patients and MethodsThis single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for BTX‐A injections at our outpatient urogynaecology clinic
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Comparison of serum and plasma microRNA expression levels in patients with germ cell tumours BJU Int. (IF 3.7) Pub Date : 2025-01-10 Fady Baky, Richard S. Matulewicz, Andrea Knezevic, Jahwa Hossain, Brandon Williams, Anna Lee, Joel Sheinfeld, Nicole Liso, Rachel So, Alisa Valentino, Fei Ye, Samuel A. Funt, Darren R. Feldman
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Navigating choices: understanding the decision‐making journey of patients with localised kidney cancer BJU Int. (IF 3.7) Pub Date : 2025-01-08 Katharina Beyer, Lionne D.F. Venderbos, Monique J. Roobol, Rachel H. Giles, Paul Verhagen, Ravi Barod, Lisa M. Wintner, Michael A.S. Jewett, Mieke Van Hemelrijck, Netty Kinsella
ObjectiveTo explore patients’ experience of decision making regarding treatment of localised kidney cancer.MethodsA total of 21 patients with localised kidney cancer, across three countries, participated in either four focus groups or seven semi‐structured interviews that lasted on average 2 h. Focus groups and interviews were all conducted in the participants' native language, recorded, transcribed
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Impact of intraprostatic PSMA maximum standardised uptake value following prostatectomy: a systematic review and meta‐analysis BJU Int. (IF 3.7) Pub Date : 2025-01-07 David C. Chen, Siyu Huang, Nathan Papa, Shankar Siva, Damien M. Bolton, Nathan Lawrentschuk, Louise Emmett, Declan G. Murphy, Michael S. Hofman, Marlon L. Perera
ObjectiveTo perform a systematic review and meta‐analysis to assess the relationship between intraprostatic maximum standardised uptake value (SUVmax) of the dominant prostatic lesion as measured on preoperative prostate‐specific membrane antigen (PSMA) positron emission tomography (PET) with radical prostatectomy International Society of Urological Pathology (ISUP) Grade Group, pathological tumour
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‘BJUI Clinical Dilemma’: the incidental small renal mass in a solitary kidney BJU Int. (IF 3.7) Pub Date : 2025-01-07 Bruce Gao, Pratik Kanabur, Riccardo Campi, Maxine Tran, Jaime Landman, Ivan Pedrosa, Ben Challacombe, Tze Min Wah, Shankar Siva, Michael Jewett, Grant D. Stewart, Brian Shuch, Ralph Clayman
Introduction The incidental small renal mass (SRM; ≤4 cm; clinical T stage [cT]1a) has become increasingly common due to the widespread utilisation of ultrasonography and cross-sectional imaging. Today, most such patients present with asymptomatic, localised disease that can be surgically treated with curative intent; however, up to 25% of SRMs are benign [1]. This creates a clinical dilemma: balancing
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Selective treatment de‐escalation in advanced prostate cancer: have we come full circle? BJU Int. (IF 3.7) Pub Date : 2025-01-03 Bryan Chong, Marniza Saad, Tsung Wen Chong, John Thng, Yu Guang Tan, Kae Jack Tay, Christopher Cheng, Po‐Hung Lin, Jeremy Teoh, Peter Ka‐Fung Chiu, Nathan Lawrentschuk, Renu Eapen, Declan Murphy, Johan Chan, Melvin L.K. Chua, Jeffrey Tuan, John Yuen, Ravindran Kanesvaran, Kenneth Chen
Compelling evidence has solidified the notion of early treatment intensification in managing patients with metastatic hormone‐sensitive prostate cancer (mHSPC). Landmark trials have provided Level 1 evidence for the survival benefits achieved by combining multiple agents. The efficacy of combined therapy relies not only on how treatment is intensified but also on how it is de‐escalated. This underscores
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TYTOCARE™ home telemonitoring device after radical cystectomy to optimise postoperative outcomes BJU Int. (IF 3.7) Pub Date : 2024-12-27 Daniele Amparore, Sabrina De Cillis, Marco Colombo, Valentina Garzena, Michele Sica, Enrico Checcucci, Alberto Piana, Federico Piramide, Alberto Quarà, Matteo Manfredi, Cristian Fiori, Francesco Porpiglia
ObjectivesTo evaluate the role of the TYTOCARE™ telemedicine programme for home telemonitoring during the early postoperative period following radical cystectomy (RC) in a prospective single‐centre study.Materials and MethodsThe study included patients aged <80 years with internet access who underwent RC at our institution between March 2021 and August 2023. Upon discharge, patients were monitored
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Correction to “How can we reduce morbidity after robot‐assisted radical cystectomy with intracorporeal neobladder? A report on postoperative complications by the European Association of Urology Robotic Urology Section Scientific Working Group” BJU Int. (IF 3.7) Pub Date : 2024-12-26
Pellegrino F., Martini A., Falagario U.G. et al. How can we reduce morbidity after robot-assisted radical cystectomy with intracorporeal neobladder? A report on postoperative complications by the European Association of Urology Robotic Urology Section Scientific Working Group, BJU Int. 2024 Jun;133(6):673–677. doi: 10.1111/bju.16283 The author affiliations published in the June 2024 issue were incorrect
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Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease BJU Int. (IF 3.7) Pub Date : 2024-12-24 Sophie L. Harding, Marcus M. Ilg, Stephen A. Bustin, David J. Ralph, Selim Cellek
ObjectivesTo investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.Materials and MethodsFibroblasts isolated from the TA of men undergoing surgery for correction of PD
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External validation of predictive models for antibiotic susceptibility of urine culture BJU Int. (IF 3.7) Pub Date : 2024-12-23 Glenn T. Werneburg, Daniel D. Rhoads, Alex Milinovich, Sean McSweeney, Jacob Knorr, Lyla Mourany, Alex Zajichek, Howard B. Goldman, Georges‐Pascal Haber, Sandip P. Vasavada
ObjectiveTo develop, externally validate, and test a series of computer algorithms to accurately predict antibiotic susceptibility test (AST) results at the time of clinical diagnosis, up to 3 days before standard urine culture results become available, with the goal of improving antibiotic stewardship and patient outcomes.Patients and MethodsMachine learning algorithms were developed and trained to
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Metastatic risk in clear cell renal cell carcinoma: a tool incorporating sex, size, and grade BJU Int. (IF 3.7) Pub Date : 2024-12-20 Frederik F. Thomsen, Marcus Westerberg, Rasmus D. Petersson, Rasmine Bak, Julie Bak Lindholst, Hayder Al‐Husseinawi, Emma Heeno, Nessn H. Azawi
ObjectiveTo identify predictors of metastases, estimate the proportion of metastatic clear cell renal cell carcinoma (ccRCC) cases according to these predictors, and subsequently create a risk table showing the absolute difference in metastasis proportion for each 10 mm increase in tumour size.Patients and MethodsPatients diagnosed with histopathological confirmed ccRCC in 2010–2018 in Denmark identified
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Sharing surgical images on social media: a snapshot of practices and some reflections for improvement BJU Int. (IF 3.7) Pub Date : 2024-12-16 Patrick Juliebø‐Jones, Vineet Gauhar, Ali Talyshinskii, Christian Arvei Moen, Ingunn Roth, Lazaros Tzelves, Christian Beisland, Bhaskar K Somani
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Impact of patient positioning during surgery on neuropathies after robot‐assisted laparoscopic radical prostatectomy: a randomised controlled trial BJU Int. (IF 3.7) Pub Date : 2024-12-13 Nico Christian Grossmann, Fabian Joel Aschwanden, Julian Cornelius, Christian Malkmus, Leutrim Zahiti, Pascal Viktorin, Lea Fierley, Einar Wilder‐Smith, Philipp Baumeister, Agostino Mattei, Christian Daniel Fankhauser
ObjectiveTo investigate whether ankle braces or shoulder support used for fixation during robot‐assisted radical prostatectomy (RARP), where patients are commonly positioned in the head‐down Trendelenburg position, differ in their potential to cause peripheral nerve injury.Patients and MethodsA prospective, double‐blind, randomised controlled trial was conducted on patients undergoing RARP for prostate
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Primary retroperitoneal lymph node dissection in clinical stage 2a/b non-seminomatous germ cell tumour BJU Int. (IF 3.7) Pub Date : 2024-12-11 Luca Antonelli, Axel Heidenreich, Aditya Bagrodia, Armon Amini, Fady Baky, Nicolas Branger, Walter Cazzaniga, Timothy N. Clinton, Siamak Daneshmand, Hooman Djaladat, Scott Eggener, Alireza Ghoreifi, Robert J. Hamilton, Matthew Ho, Wade J. Sexton, Sebastiano Nazzani, David Nicol, Nicola Nicolai, Kathleen Olson, Pia Paffenholz, James Porter, Zhiyu Qian, Nicholas R. Rocco, Anirudh Yerrapragada, Sean P
To reassess the role of primary retroperitoneal lymph node dissection (RPLND) in patients with marker-negative non-seminomatous germ cell tumour (NSGCT) clinical stage (CS) 2a, to explore results in patients with CS 2b and to evaluate surgical methods, recurrence, and adjuvant chemotherapy indications.
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Survival after trimodal therapy in octogenarians with organ‐confined urothelial bladder cancer BJU Int. (IF 3.7) Pub Date : 2024-12-12 Mattia Longoni, Francesco Di Bello, Natali Rodriguez Peñaranda, Fabian Falkenbach, Andrea Marmiroli, Quynh Chi Le, Zhe Tian, Jordan A. Goyal, Nicola Longo, Salvatore Micali, Markus Graefen, Gennaro Musi, Felix K. H. Chun, Fred Saad, Shahrokh F. Shariat, Marco Moschini, Giorgio Gandaglia, Francesco Montorsi, Alberto Briganti, Pierre I. Karakiewicz
ObjectivesIt is not known whether cancer‐specific mortality (CSM) differences distinguish radical cystectomy (RC) from trimodal therapy (TMT) in octogenarians harbouring organ‐confined (T2N0M0) urothelial cancer of the urinary bladder (UCUB).MethodsWithin the Surveillance, Epidemiology, and End Results database (2004–2021), CSM and other‐cause mortality (OCM) rates were computed in octogenarian patients
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The impact of post‐nephroureterectomy surgically induced chronic kidney disease on survival outcomes BJU Int. (IF 3.7) Pub Date : 2024-12-12 Dhruv Puri, Margaret F. Meagher, Zhenjie Wu, Antonio Franco, Linhui Wang, Vitaly Margulis, Raj Bhanvadia, Firas Abdollah, Marco Finati, Alessandro Antonelli, Francesco Ditonno, Nirmish Singla, Stephan Broenimann, Giuseppe Simone, Gabriele Tuderti, Soroush Rais‐Bahrami, Sol C. Moon, Matteo Ferro, Marco Tozzi, Francesco Porpiglia, Daniele Amparore, Andreas Correa, Emma Helstrom, Mark L. Gonzalgo, Dinno
ObjectiveTo investigate the prevalence, predictors and impact of surgically induced chronic kidney disease (CKD‐S) on survival outcomes in patients with upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU).MethodsUtilising the ROBUUST 2.0 registry, a multicentre retrospective analysis was conducted in patients with UTUC undergoing RNU between 2006 and 2022 who did not
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The role of social media in education: how to maximise learning BJU Int. (IF 3.7) Pub Date : 2024-12-12 Thomas Hughes, Bhaskar K Somani
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New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation BJU Int. (IF 3.7) Pub Date : 2024-12-11 Chrystal Chang, David W. Barham, Zafardjan Dalimov, Daniel Swerdloff, Hossein Sadeghi‐Nejad, Robert Andrianne, Maxime Sempels, Tung‐Chin Hsieh, Georgios Hatzichristodoulou, Muhammed Hammad, Jake Miller, Daniar Osmonov, Aaron Lentz, Paul Perito, Alfredo Suarez‐Sarmiento, James Hotaling, Kelli Gross, James M Jones, Koenraad van Renterghem, Sung Hun Park, Jonathan N. Warner, Matthew Ziegelmann, Vaibhav
ObjectivesTo evaluate the pre‐ and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized.Patients and MethodsWe retrospectively reviewed a 16‐centre multi‐institutional database of IPP surgeries performed
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Sarcopenia may increase cisplatin toxicity in bladder cancer patients with borderline renal function BJU Int. (IF 3.7) Pub Date : 2024-12-10 Eiftu S. Haile, Zaeem Lone, David Shin, Amy S. Nowacki, Nicolas Soputro, Kyle Harris, Rebecca A. Campbell, Andrew Wood, Samuel C. Haywood, Mohamed Eltemamy, Georges‐Pascal Haber, Christopher J. Weight, Hadley M. Wood, Jonathan J. Taliercio, Amanda Nizam, Shilpa Gupta, Erick M. Remer, Nima Almassi
ObjectivesTo assess whether the effect of sarcopenia on neoadjuvant chemotherapy (NAC) toxicity is modified by borderline renal function (estimated glomerular filtration rate [eGFR] 40–65 mL/min) and whether sarcopenia and borderline renal function are independently associated with NAC toxicity risk.Patients and MethodsAll patients with muscle‐invasive bladder cancer (MIBC) who underwent radical cystectomy
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Novel bioabsorbable, low‐dose rate brachytherapy device (CivaSheet®) with radical prostatectomy and adjuvant external beam radiation for the management of prostate cancer BJU Int. (IF 3.7) Pub Date : 2024-12-10 Kennedy E. Okhawere, Shirin Razdan, Alp Tuna Beksac, Indu Saini, Laura Zuluaga, Kirolos Meilika, Burak Ucpinar, Ren‐Dih Sheu, Reza Mehrazin, John Sfakianos, Ashutosh Tewari, Richard G. Stock, Ketan Badani
ObjectiveTo investigate the safety and cancer control of a novel bioabsorbable, low‐dose rate brachytherapy device, CivaSheet® (CivaTech Oncology Inc., Durham, NC, USA), in combination with radical prostatectomy (RP) with or without adjuvant external beam radiation therapy (EBRT) for the management of prostate cancer (PCa).Patients and MethodsThis is an initial, single‐centre experience, two‐dose level
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A Prostate Imaging‐Reporting and Data System version 2.1‐based predictive model for clinically significant prostate cancer diagnosis BJU Int. (IF 3.7) Pub Date : 2024-12-10 David G. Gelikman, William S. Azar, Enis C. Yilmaz, Yue Lin, Luke A. Shumaker, Andrew M. Fang, Stephanie A. Harmon, Erich P. Huang, Sahil H. Parikh, Jason A. Hyman, Kyle Schuppe, Jeffrey W. Nix, Samuel J. Galgano, Maria J. Merino, Peter L. Choyke, Sandeep Gurram, Bradford J. Wood, Soroush Rais‐Bahrami, Peter A. Pinto, Baris Turkbey
ObjectivesTo develop and validate a Prostate Imaging‐Reporting and Data System (PI‐RADS) version 2.1 (v2.1)‐based predictive model for diagnosis of clinically significant prostate cancer (csPCa), integrating clinical and multiparametric magnetic resonance imaging (mpMRI) data, and compare its performance with existing models.Patients and MethodsWe retrospectively analysed data from patients who underwent
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Diagnostic and prognostic genomic aberrations in upper tract urothelial carcinoma can be identified in focal barbotage samples BJU Int. (IF 3.7) Pub Date : 2024-12-10 Tomas Andri Axelsson, Filip Sydén, Jesper Eisfeldt, Ylva Eriksson, Gustav Göthner Lundberg, Georg Jaremko, Ollanta Cuba Gyllensten, Emma Tham, Marianne Brehmer
ObjectivesTo investigate whether genetic analysis of focal barbotage samples obtained at ureterorenoscopy (URS) is possible, and to identify genetic aberrations that might add prognostic information.MethodsThis prospective study included barbotage samples from 42 patients with upper urinary tract urothelial carcinoma (UTUC) confirmed at URS. At URS, focal barbotage specimens were collected for cytology
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January's reviewers of the month BJU Int. (IF 3.7) Pub Date : 2024-12-10
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