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Stress-related disorders and subsequent cancer risk and mortality: a population-based and sibling-controlled cohort study in Sweden Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-08-13 Fan Tian, Fang Fang, Qing Shen, Weimin Ye, Unnur A. Valdimarsdóttir, Huan Song
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The estimated disease burden of acute COVID-19 in the Netherlands in 2020, in disability-adjusted life-years Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-08-11 Scott A. McDonald, Giske R. Lagerweij, Pieter de Boer, Hester E. de Melker, Roan Pijnacker, Lapo Mughini Gras, Mirjam E. Kretzschmar, Gerco den Hartog, Arianne B. van Gageldonk-Lafeber, Susan van den f, Jacco Wallinga
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Systematic review and meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19 Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-08-09 Xabier García-Albéniz, Julia del Amo, Rosa Polo, José Miguel Morales-Asencio, Miguel A Hernán
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Maternal antibiotic use and infections during pregnancy and offspring asthma: the Norwegian Mother, Father and Child Cohort Study and a nationwide register cohort Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-08-08 Aino K. Rantala, German Tapia, Maria C. Magnus, Lars C. Stene, Jouni J.K. Jaakkola, Ketil Størdal, Øystein Karlstad, Wenche Nystad
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The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-07-29 Maximilian Schons, Lisa Pilgram, Jens-Peter Reese, Melanie Stecher, Gabriele Anton, Katharina S. Appel, Thomas Bahmer, Alexander Bartschke, Carla Bellinghausen, Inga Bernemann, Markus Brechtel, Folke Brinkmann, Clara Brünn, Christine Dhillon, Cornelia Fiessler, Ramsia Geisler, Eckard Hamelmann, Stefan Hansch, Frank Hanses, Sabine Hanß, Susanne Herold, Ralf Heyder, Anna-Lena Hofmann, Sina Marie Hopff
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The effect of farming environment on asthma; time dependent or universal? Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-07-27 Marie Kjær Madsen, Vivi Schlünssen, Cecilie Svanes, Ane Johannessen, Nils Oskar Jõgi, Mathias Holm, Christer Janson, Antonio Pereira-Vega, Adrian J. Lowe, Karl A. Franklin, Andrei Malinovschi, Torben Sigsgaard, Michael J. Abramson, Randi Bertelsen, Anna Oudin, Thorarinn Gislason, Signe Timm
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The diverse life-course cohort (DLCC): protocol of a large-scale prospective study in China Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-07-19 Huijing He, Li Pan, Yaoda Hu, Ji Tu, Ling Zhang, Minying Zhang, Gongshu Liu, Juxiang Yuan, Qiong Ou, Zhiwei Sun, Jing Nai, Ze Cui, Jingbo Zhang, Jing Wang, Jianhui Wu, Xiaoyan Han, Yujie Niu, Xiaoming Li, Dongqing Hou, Chengdong Yu, Chenchen Jiang, Qihang Liu, Binbin Lin, Guangliang Shan
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The Swedish military conscription register: opportunities for its use in medical research Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-07-09 Jonas F. Ludvigsson, Daniel Berglind, Kristina Sundquist, Johan Sundström, Per Tynelius, Martin Neovius
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A structural characterization of shortcut features for prediction Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-07-06 David Bellamy, Miguel A. Hernán, Andrew Beam
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Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-07-05 Thomas R. Austin, Caitlin P. McHugh, Jennifer A. Brody, Joshua C. Bis, Colleen M. Sitlani, Traci M. Bartz, Mary L. Biggs, Nisha Bansal, Petra Buzkova, Steven A. Carr, Christopher R. deFilippi, Mitchell S. V. Elkind, Howard A. Fink, James S. Floyd, Alison E. Fohner, Robert E. Gerszten, Susan R. Heckbert, Daniel H. Katz, Jorge R. Kizer, Rozenn N. Lemaitre, W. T. Longstreth, Barbara McKnight, Hao Mei
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Defective placentation syndromes and autism spectrum disorder in the offspring: population-based cohort and sibling-controlled studies Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-07-05 Eduardo Villamor, Ezra S. Susser, Sven Cnattingius
Defective placentation underlies diverse syndromic manifestations that could affect brain development including: (1) placental abruption, (2) term preeclampsia with a small-for-gestational age (SGA) infant, (3) preterm preeclampsia, and (4) spontaneous preterm birth. We investigated the relations between these defective placentation syndromes and the incidence of Autism Spectrum Disorder (ASD) in offspring
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Mortality in adult children of parents with alcohol use disorder: a nationwide register study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-06-23 Jeanette Westman, Nitya Jayaram-Lindström, Kimberly Kane, Johan Franck, Mika Gissler
Research suggests that adult children of parents with harmful alcohol use are at increased risk for premature death. This national cohort study investigated mortality in adult children of parents with alcohol use disorder (AUD), adjusting for sociodemographic variables. The study used 1973 to 2018 data from Swedish national registers to compare mortality risk in children who had ≥ 1 parent with AUD
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The comparative mortality of an elite group in the long run of history: an observational analysis of politicians from 11 countries Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-06-23 Philip M. Clarke, An Tran-Duy, Laurence S. J. Roope, Jay A. Stiles, Adrian G. Barnett
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Sex differences in the mortality rate for coronavirus disease 2019 compared to other causes of death: an analysis of population-wide data from 63 countries Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-06-23 Pascal Geldsetzer, Trasias Mukama, Nadine Kamel Jawad, Tim Riffe, Angela Rogers, Nikkil Sudharsanan
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Projected prevalence and incidence of dementia accounting for secular trends and birth cohort effects: a population-based microsimulation study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-06-22 Chiara Celine Brück, Frank J. Wolters, M. Arfan Ikram, Inge M.C.M. de Kok
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Cohort Profile Update: the China Metal-Exposed workers Cohort Study (Jinchang Cohort) Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-06-17 Yana Bai, Jingli Yang, Zhiyuan Cheng, Desheng Zhang, Ruonan Wang, Rui Zhang, Zhao Bai, Shan Zheng, Minzhen Wang, Chun Yin, Xiaobin Hu, Yufeng Wang, Lulu Xu, Yarong Chen, Jing Li, Siyu Li, Yujia Hu, Na Li, Wenling Zhang, Yanyan liu, Juansheng Li, Xiaowei Ren, Feng Kang, Xijiang Wu, Jiao Ding, Ning Cheng
The Jinchang Cohort was an ongoing 20-year ambispective cohort with unique metal exposures to an occupational population. From January 2014 to December 2019, the Jinchang Cohort has completed three phases of follow-up. The baseline cohort was completed from June 2011 to December 2013, and a total of 48 001 people were included. Three phases of follow-ups included 46 713, 41 888, and 40 530 participants
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Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-06-16 Xuan Zhou, Lili Yu, Lijuan Wang, Jiarui Xiao, Jing Sun, Yajing Zhou, Xiaolin Xu, Wanghong Xu, Athina Spiliopoulou, Maria Timofeeva, Xiaomeng Zhang, Yazhou He, Haomin Yang, Harry Campbell, Ben Zhang, Yimin Zhu, Evropi Theodoratou, Xue Li
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Hospitalisation rate and mortality among people with and without diabetes during the COVID-19 pandemic year 2020 Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-06-08 Maria Narres, Heiner Claessen, Tatjana Kvitkina, Joachim Rosenbauer, Maria Scheider, Stephan Morbach, Andrea Icks
Most studies reported reduced health care use among people with diabetes during the COVID-19 pandemic. This may be due to restricted medical services or people avoiding health care services because they fear being infected with COVID-19 in health care facilities. The aim of our study was to analyse hospitalisation and mortality in people with and without diabetes in Germany during the COVID-19 pandemic
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Statistical Analysis in the German National Cohort (NAKO) – Specific Aspects and General Recommendations Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-06-02 Oliver Kuss, Heiko Becher, Andreas Wienke, Till Ittermann, Stefan Ostrzinski, Sabine Schipf, Carsten O Schmidt, Michael Leitzmann, Tobias Pischon, Lilian Krist, Stephanie Roll, Matthias Sand, Hermann Pohlabeln, Stefan Rach, Karl-Heinz Jöckel, Andreas Stang, Ulrich A Mueller, Andrea Werdecker, Ronny Westerman, Karin H Greiser, Karin B Michels
The German National Cohort (NAKO) is an ongoing, prospective multicenter cohort study, which started recruitment in 2014 and includes more than 205,000 women and men aged 19–74 years. The study data will be available to the global research community for analyses. Although the ultimate decision about the analytic methods will be made by the respective investigator, in this paper we provide the basis
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Avoiding collider bias in Mendelian randomization when performing stratified analyses Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-05-31 Claudia Coscia, Dipender Gill, Raquel Benítez, Teresa Pérez, Núria Malats, Stephen Burgess
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Transmission of SARS-CoV-2 within households: a remote prospective cohort study in European countries Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-05-28 Janneke D. M. Verberk, Marieke L. A. de Hoog, Ilse Westerhof, Sam van Goethem, Christine Lammens, Greet Ieven, Erwin de Bruin, Dirk Eggink, Julia A. Bielicki, Samuel Coenen, Janko van Beek, Marc J. M. Bonten, Herman Goossens, Patricia C. J. L. Bruijning-Verhagen
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Nuts and legumes consumption and risk of colorectal cancer: a systematic review and meta-analysis Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-05-27 Shaoyue Jin, Youjin Je
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Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-05-27 Qian Yang, Eleanor Sanderson, Kate Tilling, Maria Carolina Borges, Deborah A. Lawlor
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Sedentary behavior and cancer–an umbrella review and meta-analysis Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-05-25 Rafael Hermelink, Michael F. Leitzmann, Georgios Markozannes, Kostas Tsilidis, Tobias Pukrop, Felix Berger, Hansjörg Baurecht, Carmen Jochem
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Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-05-20 Dusan Petrovic, Barbara Bodinier, Sonia Dagnino, Matthew Whitaker, Maryam Karimi, Gianluca Campanella, Therese Haugdahl Nøst, Silvia Polidoro, Domenico Palli, Vittorio Krogh, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Eiliv Lund, Pierre-Antoine Dugué, Graham G. Giles, Gianluca Severi, Melissa Southey, Paolo Vineis, Silvia Stringhini, Murielle Bochud, Torkjel M. Sandanger, Roel C. H. Vermeulen
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Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-05-06 Tobias Niedermaier, Thomas Gredner, Sabine Kuznia, Ben Schöttker, Ute Mons, Jeroen Lakerveld, Wolfgang Ahrens, Hermann Brenner
Background: Meta-analyses of randomized controlled trials have shown that vitamin D supplementation reduces cancer mortality by 13%. Vitamin D fortification of foods may increase vitamin D levels in a similar manner as vitamin D supplementation and could achieve similar reductions in cancer mortality. Whereas some European countries already implemented widespread fortification of foods with vitamin
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Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-30 Shuai Yuan, Jie Chen, Xue Li, Rongrong Fan, Benoit Arsenault, Dipender Gill, Edward L. Giovannucci, Ju-sheng Zheng, Susanna C. Larsson
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A twenty-first century perspective on concepts of modern epidemiology in Ignaz Philipp Semmelweis’ work on puerperal sepsis Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-29 Andreas Stang, Fabian Standl, Charles Poole
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Fetal exposure to maternal cigarette smoking and male reproductive function in young adulthood Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-27 Katia Keglberg Hærvig, Kajsa Ugelvig Petersen, Aleksander Giwercman, Karin Sørig Hougaard, Birgit Bjerre Høyer, Christian Lindh, Cecilia Høst Ramlau-Hansen, Anne-Marie Nybo Andersen, Gunnar Toft, Jens Peter Bonde, Sandra Søgaard Tøttenborg
Maternal smoking during pregnancy constitutes a potential, major risk factor for adult male reproductive function. In the hitherto largest longitudinal cohort, we examined biomarkers of reproductive function according to maternal smoking during the first trimester and investigated whether associations were mitigated by smoking cessation prior to the fetal masculinization programming window. Associations
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APOE ε4 and late-life cognition: mediation by structural brain imaging markers Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-26 Yuan Ma, Gautam Sajeev, Tyler J. VanderWeele, Anand Viswanathan, Sigurdur Sigurdsson, Gudny Eiriksdottir, Thor Aspelund, Rebecca A. Betensky, Francine Grodstein, Albert Hofman, Vilmundur Gudnason, Lenore Launer, Deborah Blacker
The apolipoprotein E allele 4 (APOE-ε4) is established as a major genetic risk factor for cognitive decline and late-onset Alzheimer’s disease. Accumulating evidence has linked ε4 carriership to abnormal structural brain changes across the adult lifespan. To better understand the underlying causal mechanisms, we investigated the extent to which the effect of the ε4 allele on cognition is mediated by
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Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-23 Bin Zhao, Lu Gan, Kai Yu, Satu Männistö, Jiaqi Huang, Demetrius Albanes
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War in Europe: health implications of environmental nuclear disaster amidst war Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-15 Jessica E Laine
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Dietary fat intake and risk of Parkinson disease: results from the Swedish National March Cohort Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-13 Essi Hantikainen, Elin Roos, Rino Bellocco, Alessia D’Antonio, Alessandra Grotta, Hans-Olov Adami, Weimin Ye, Ylva Trolle Lagerros, Stephanie Bonn
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COVID-19 prevalence and mortality in longer-term care facilities Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-10 Andrew T. Levin, Juulia Jylhävä, Dorota Religa, Laura Shallcross
This essay considers the factors that have contributed to very high COVID-19 mortality in longer-term care facilities (LTCFs). We compare the demographic characteristics of LTCF residents with those of community-dwelling older adults, and then we review the evidence regarding prevalence and infection fatality rates (IFRs), including links to frailty and some comorbidities. Finally, we discuss policy
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Development in life expectancy with good and poor cognitive function in the elderly European Population from 2004-05 to 2015 Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-08 Camilla Riis Nielsen, Linda Juel Ahrenfeldt, Bernard Jeune, Kaare Christensen, Rune Lindahl-Jacobsen
Background Living not just longer, but also cognitively healthier, and more independent lives is essential if European countries are to cope with the financial challenges that the shifting age composition of Europe’s population presents. Here we investigate the change in life expectancy (LE) spent with good and poor cognitive function among older adults across Europe. Methods LE with good/poor cognitive
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Physical activity and cardiometabolic risk factors in individuals with spinal cord injury: a systematic review and meta-analysis Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-04-07 Oche Adam Itodo, Joelle Leonie Flueck, Peter Francis Raguindin, Stevan Stojic, Mirjam Brach, Claudio Perret, Beatrice Minder, Oscar H. Franco, Taulant Muka, Gerold Stucki, Jivko Stoyanov, Marija Glisic
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Handling unobserved confounding in the relation between prenatal risk factors and child outcomes: a latent variable strategy Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-03-26 Kristin Gustavson, George Davey Smith, Espen M. Eilertsen
Background Several studies have examined maternal health behavior during pregnancy and child outcomes. Negative control variables have been used to address unobserved confounding in such studies. This approach assumes that confounders affect the exposure and the negative control to the same degree. The current study introduces a novel latent variable approach that relaxes this assumption by accommodating
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Work stress and loss of years lived without chronic disease: an 18-year follow-up of 1.5 million employees in Denmark Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-03-21 Jeppe K. Sørensen, Elisabeth Framke, Jacob Pedersen, Kristina Alexanderson, Jens P. Bonde, Kristin Farrants, Esben M. Flachs, Linda L. Magnusson Hanson, Solja T. Nyberg, Mika Kivimäki, Ida E. H. Madsen, Reiner Rugulies
We aimed to examine the association between exposure to work stress and chronic disease incidence and loss of chronic disease-free life years in the Danish workforce. The study population included 1,592,491 employees, aged 30–59 in 2000 and without prevalent chronic diseases. We assessed work stress as the combination of job strain and effort-reward imbalance using job exposure matrices. We used Cox
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Generalizability and effect measure modification in sibling comparison studies Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-03-21 Arvid Sjölander, Sara Öberg, Thomas Frisell
Sibling comparison studies have the attractive feature of being able to control for unmeasured confounding by factors that are shared within families. However, there is sometimes a concern that these studies may have poor generalizability (external validity) due to the implicit restriction to families that are covariate-discordant, i.e., those families where at least two siblings have different levels
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Infection fatality rate of COVID-19 in community-dwelling elderly populations Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-03-20 Cathrine Axfors, John P. A. Ioannidis
This mixed design synthesis aimed to estimate the infection fatality rate (IFR) of Coronavirus Disease 2019 (COVID-19) in community-dwelling elderly populations and other age groups from seroprevalence studies. Protocol: https://osf.io/47cgb. Eligible were seroprevalence studies done in 2020 and identified by any of four existing systematic reviews; with ≥ 500 participants aged ≥ 70 years; presenting
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Statin use is associated with lower risk of dementia in stroke patients: a community-based cohort study with inverse probability weighted marginal structural model analysis Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-03-19 Zhirong Yang, Sengwee Toh, Xiaojuan Li, Duncan Edwards, Carol Brayne, Jonathan Mant
Current evidence is inconclusive on cognitive benefits or harms of statins among stroke patients, who have high risk of dementia. This observational cohort study investigated the association between statin use and post-stroke dementia using data from the Clinical Practice Research Datalink. Patients without prior dementia who had an incident stroke but received no statins in the preceding year were
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Incidence of Parkinson’s disease in French women from the E3N cohort study over 27 years of follow-up Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-03-14 Marianne Canonico, Fanny Artaud, Isabelle Degaey, Frédéric Moisan, Rahime Kabore, Berta Portugal, Thi Thu Ha Nguyen, Giancarlo Pesce, Marie-Christine Boutron-Ruault, Emmanuel Roze, Alexis Elbaz
Parkinson’s disease (PD) is an uncommon disease with a long prodromal period and higher incidence in men than women. Large cohort studies of women with a long follow-up are needed. Within the E3N French cohort study (98,995 women, 40–65 years at baseline), we identified 3,584 participants who self-reported PD or used anti-parkinsonian drugs over 27 years (1992–2018). We obtained medical records to
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Years of life lost methods must remain fully equitable and accountable. Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-03-04 Grant M A Wyper,Brecht Devleesschauwer,Colin D Mathers,Scott A McDonald,Niko Speybroeck
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Impact of uncertainties in exposure assessment on thyroid cancer risk among cleanup workers in Ukraine exposed due to the Chornobyl accident Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-28 Mark P. Little, Elizabeth K. Cahoon, Natalia Gudzenko, Kiyohiko Mabuchi, Vladimir Drozdovitch, Maureen Hatch, Alina V. Brenner, Vibha Vij, Konstantin Chizhov, Elena Bakhanova, Natalia Trotsyuk, Victor Kryuchkov, Ivan Golovanov, Vadim Chumak, Dimitry Bazyka
A large excess risk of thyroid cancer was observed among Belarusian/Russian/Baltic Chornobyl cleanup workers. A more recent study of Ukraine cleanup workers found more modest excess risks of thyroid cancer. Dose errors in this data are substantial, associated with model uncertainties and questionnaire response. Regression calibration is often used for dose-error adjustment, but may not adequately account
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Re: The limits of small-for-gestational-age as a high-risk category Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-26 Lin Yang,Thomas Waldhoer
With great interest, we read the study by Wilcox et. al. “The limits of small‐for‐gestational‐age as a high‐risk category” [1], which showed that small‐for‐gestational age (SGA) was a poor marker for predicting neonatal mortality and cerebral palsy, whilst gestational age performed well. Following the same selection criteria, we used birth certificate data of Aus‐ trian newborns between 1984 and 2019
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Subjective cognitive decline and total energy intake: Talk too much? Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-25 Lewis H. Kuller
The increasing longevity of the population has resulted in dementia becoming a leading cause of both death and disability. Dementia is not a single disease. Studies of rare Mendelian disorders have documented that Alzheimer's disease, the most common cause of dementia, is associated with a long incubation period from amyloid deposition to neurodegeneration to mild cognitive impairment and dementia
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Excess risk and clusters of symptoms after COVID-19 in a large Norwegian cohort Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-25 Ida Henriette Caspersen, Per Magnus, Lill Trogstad
Physical, psychological and cognitive symptoms have been reported as post-acute sequelae for COVID-19 patients but are also common in the general uninfected population. We aimed to calculate the excess risk and identify patterns of 22 symptoms up to 12 months after COVID-19. We followed more than 70,000 adult participants in an ongoing cohort study, the Norwegian Mother, Father and Child Cohort Study
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Predicting counterfactual risks under hypothetical treatment strategies: an application to HIV Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-22 Barbra A. Dickerman, Issa J. Dahabreh, Krystal V. Cantos, Roger W. Logan, Sara Lodi, Christopher T. Rentsch, Amy C. Justice, Miguel A. Hernán
The accuracy of a prediction algorithm depends on contextual factors that may vary across deployment settings. To address this inherent limitation of prediction, we propose an approach to counterfactual prediction based on the g-formula to predict risk across populations that differ in their distribution of treatment strategies. We apply this to predict 5-year risk of mortality among persons receiving
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The China birth cohort study (CBCS) Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-11 Wentao Yue, Enjie Zhang, Ruixia Liu, Yue Zhang, Chengrong Wang, Shen Gao, Shaofei Su, Xiao Gao, Qingqing Wu, Xiaokui Yang, Aris T. Papageorghiou, Chenghong Yin
The China birth cohort study (CBCS) is a prospective longitudinal, mega-cohort study and the first national-based birth cohort study, aiming to establish a birth cohort covering representative geographical areas of the whole of China to investigate risk factors for birth defects and develop strategies for their reduction. Pregnant women who are of Chinese nationality, are 6–13+6 weeks of gestation
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Cardiorespiratory fitness does not offset the increased risk of chronic obstructive pulmonary disease attributed to smoking: a cohort study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-05 Setor K. Kunutsor, Sae Young Jae, Timo H. Mäkikallio, Jari A. Laukkanen
Though evidence suggests that higher cardiorespiratory fitness (CRF) levels can offset the adverse effects of other risk factors, it is unknown if CRF offsets the increased risk of chronic obstructive pulmonary disease (COPD) due to smoking. We aimed to evaluate the combined effects of smoking status and CRF on incident COPD risk using a prospective cohort of 2295 middle-aged and older Finnish men
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Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-04 Shuai Yuan, Susanna C. Larsson
Adiposity, diabetes, and lifestyle factors are linked to gastroesophageal reflux disease (GERD) in observational studies. We conducted a two-sample Mendelian randomization analysis to determine whether those associations are causal. Independent genetic variants associated with body mass index (BMI), waist circumference (with and without adjustment for BMI), type 2 diabetes, smoking, and alcohol, coffee
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Association of allergic diseases and epilepsy with risk of glioma, meningioma and acoustic neuroma: results from the INTERPHONE international case–control study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-02-03 Brigitte Schlehofer, Maria Blettner, Monika Moissonnier, Isabelle Deltour, Graham G. Giles, Bruce Armstrong, Jack Siemiatycki, Marie-Elise Parent, Daniel Krewski, Christoffer Johansen, Anssi Auvinen, Anna Lahkola, Martine Hours, Gabriele Berg-Beckhoff, Siegal Sadetzki, Susanna Lagorio, Toru Takebayashi, Naohito Yamaguchi, Alistair Woodward, Angus Cook, Tore Tynes, Lars Klaboe, Maria Feychting, Richard
We investigated the association of allergic diseases and epilepsy with risk of brain tumours, in Interphone, a 13-country case–control study. Data were obtained from 2693 glioma cases, 2396 meningioma cases, and 1102 acoustic neuroma cases and their 6321 controls. Conditional logistic regression models were used to estimate pooled odds ratios (ORs) and their respective 95% confidence intervals (CIs)
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Healthy lifestyle in older adults and life expectancy with and without heart failure Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-01-27 Marlou A. M. Limpens, Eralda Asllanaj, Lisanne J. Dommershuijsen, Eric Boersma, M. Arfan Ikram, Maryam Kavousi, Trudy Voortman
Several lifestyle factors have been linked to risk for heart failure (HF) and premature mortality. The aim of this study was to estimate the impact of a healthy lifestyle on life expectancy with and without HF among men and women from a general population. This study was performed among 6113 participants (mean age 65.8 ± 9.7 years; 58.9% women) from the Rotterdam Study, a large prospective population-based
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Risk factors for COVID-19-related death, hospitalization and intensive care: a population-wide study of all inhabitants in Stockholm Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-01-27 Maria-Pia Hergens, Max Bell, Per Haglund, Johan Sundström, Erik Lampa, Joanna Nederby-Öhd, Maria Rotzén Östlund, Thomas Cars
Since the beginning of the Covid-19 pandemic, the scientific community has explored determinants of Covid 19 disease severity. However, the majority of studies are based on in-hospital patients with high risk of collider- or selection bias. The present investigation details risk factors associated with overall mortality, hospitalization and intensive care unit (ICU) admission in Covid-19 infections
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COVID-19 and mental health: a longitudinal population study from Norway Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-01-27 Hans K. Hvide, Julian Johnsen
Existing research has found adverse short-term effects of the COVID-19 pandemic on mental health, but longer-term effects have been less documented. Using newly released register data on all general practitioner consultations in Norway through 2020 (about 14 million consultations in total), we find that during the spring and early summer 2020, the number of psychological cases initially increased relative
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Plasma metabolomic profiles for colorectal cancer precursors in women Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-01-15 Hang, Dong, Zeleznik, Oana A., Lu, Jiayi, Joshi, Amit D., Wu, Kana, Hu, Zhibin, Shen, Hongbing, Clish, Clary B., Liang, Liming, Eliassen, A. Heather, Ogino, Shuji, Meyerhardt, Jeffrey A., Chan, Andrew T., Song, Mingyang
How metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested case–control study to examine the associations of pre-diagnostic plasma metabolome (profiled using LC–MS) with risk of CRC precursors, including conventional adenomas (n = 586 vs. 1141) and serrated polyps (n = 509 vs. 993), in the Nurses' Health Study (NHS) and
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Dispositional optimism and depression risk in older women in the Nurses´ Health Study: a prospective cohort study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-01-15 Weitzer, Jakob, Trudel-Fitzgerald, Claudia, Okereke, Olivia I., Kawachi, Ichiro, Schernhammer, Eva
Dispositional optimism is a potentially modifiable factor and has been associated with multiple physical health outcomes, but its relationship with depression, especially later in life, remains unclear. In the Nurses´ Health Study (n = 33,483), we examined associations between dispositional optimism and depression risk in women aged 57–85 (mean = 69.9, SD = 6.8), with 4,051 cases of incident depression
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Protecting against researcher bias in secondary data analysis: challenges and potential solutions Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-01-13 Baldwin, Jessie R., Pingault, Jean-Baptiste, Schoeler, Tabea, Sallis, Hannah M., Munafò, Marcus R.
Analysis of secondary data sources (such as cohort studies, survey data, and administrative records) has the potential to provide answers to science and society’s most pressing questions. However, researcher biases can lead to questionable research practices in secondary data analysis, which can distort the evidence base. While pre-registration can help to protect against researcher biases, it presents
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Longitudinal trajectories of lifetime body shape and prostate cancer angiogenesis Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-01-13 Wang, Qiao-Li, Song, Mingyang, Clinton, Steven K., Mucci, Lorelei A., Lagergren, Jesper, Giovannucci, Edward L.
Angiogenesis potentially underlies the pathway between excess adiposity and prostate carcinogenesis. This study examined the association between lifetime body shape trajectories and prostate cancer angiogenesis. 521 prostate cancer patients who underwent prostatectomy or transurethral resection between 1986 and 2000 were enrolled from the Health Professionals Follow-up Study. Cancers were immunostained
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Long-term association of pregnancy and maternal brain structure: the Rotterdam Study Eur. J. Epidemiol. (IF 12.434) Pub Date : 2022-01-06 Aleknaviciute, Jurate, Evans, Tavia E., Aribas, Elif, de Vries, Merel W., Steegers, Eric A. P., Ikram, Mohammad Arfan, Tiemeier, Henning, Kavousi, Maryam, Vernooij, Meike W., Kushner, Steven A.
The peripartum period is the highest risk interval for the onset or exacerbation of psychiatric illness in women’s lives. Notably, pregnancy and childbirth have been associated with short-term structural and functional changes in the maternal human brain. Yet the long-term effects of pregnancy on maternal brain structure remain unknown. We investigated a large population-based cohort to examine the