BACKGROUND AND AIM The study 'Periodontitis and Its Relation to Coronary Artery Disease' (PAROKRANK) reported an association between periodontitis (PD) and the first myocardial infarction (MI). This follow-up study aims to test the hypothesis that those with PD-compared to periodontally healthy individuals-are at increased risk for cardiovascular (CV) events and death. METHODS A total of 1587 participants

AimAs data are sparse on the long‐term association between periodontal diseases and development of metabolic syndrome (MetS), we investigated their relationship in a Thai cohort over a 10‐year observational period.MethodsMedical records and data on periodontal assessments of 2161 employees of the Electricity Generating Authority of Thailand collected at two time points, 2003 and 2013, were used. Experienced

AimTo assess the impact of active (APT) and supportive periodontal therapy (SPT) on the change in probing depth (PD) and annual tooth loss in partially and fully compliant and drop‐out patients.Material and MethodsData of 280 periodontally treated partially and fully compliant (regular supportive visits, SPT duration 5.5 ± 4.5 years) and 55 drop‐out patients (SPT and drop‐out duration 8.3 ± 3.8 years

AimTo investigate the hypothesis supporting the link between periodontitis and dopaminergic neuron degeneration.Materials and MethodsAdult male Wistar rats were used to induce dopaminergic neuronal injury with 6‐hydroxydopamine (6‐OHDA) neurotoxin and experimental periodontitis via ligature placement. Motor function assessments were conducted before and after periodontitis induction in controls and

AimTo assess the impact of the timing of soft‐tissue augmentation (STA) on mean buccal bone changes following immediate implant placement (IPP) in the anterior maxilla.Materials and MethodsPatients with a failing tooth and intact buccal bone wall in the anterior maxilla (15–25) were enrolled in this randomized controlled trial. Following single IIP and socket grafting, they were randomly allocated

AimTo investigate the association, as well as to characterize the associated panel of pro‐ and anti‐inflammatory markers, between the different components of the peri‐implant phenotype and the presence of peri‐implantitis/peri‐implant soft‐tissue dehiscence (PISTD).Materials and MethodsA total of 324 implants in 112 patients were included. The following components of the peri‐implant phenotype were

AimTo examine the independent and joint associations of oral microbiome diversity and diet quality with risks of all‐cause and cause‐specific mortality.Materials and MethodsWe included 7,055 eligible adults from the U.S. National Health and Nutrition Examination Survey (NHANES). Oral microbiome diversity was measured with α‐diversity, including the Simpson Index, observed amplicon sequence variants

BACKGROUND Periodontal diseases are chronic inflammatory conditions that require early screening for effective long-term management. Oral neutrophil counts (ONCs) correlate with periodontal inflammation. This study investigates a point-of-care test using a neutrophil enzyme activity (NEA) colorimetric strip for measuring periodontal inflammation. METHODS This prospective study had two phases. Phase

ObjectiveTo investigate the association between interleukin‐8 (IL‐8) levels in gingival crevicular fluid (GCF) and total oral fluid (TOF) and the responsiveness to steps 1 and 2 of periodontal therapy.Materials and MethodsOne‐hundred and fifty‐nine patients affected by periodontitis received steps 1 and 2 of periodontal therapy. At baseline, TOF and GCF samples were collected and analysed for IL‐8

AimTo investigate whether oral microbiome diversity is associated with all‐cause mortality in the general US population and in individuals with chronic diseases.Materials and MethodsWe included 8224 individuals with oral microbiome diversity data from the National Health and Nutrition Examination Survey (2009–2012), representing 164,000,205 US adults, using a survey‐weighted analysis method. Cox regression

AimTo assess the possibility of vertical alveolar ridge augmentation by means of activation of the periosteum.Materials and MethodsSix adult male Beagle dogs were used for the study. All premolars and first molars were extracted, and one vertical saucer‐shaped bony defect was created on each side of the mandible. After 3 months of healing, full‐thickness muco‐periosteal flaps were elevated, and one

AimTo investigate the influence of diabetes mellitus (DM) in a murine model of peri‐implantitis (PI).Materials and MethodsTwenty‐seven 4‐week‐old C57BL/6J male mice had their first and second maxillary left molars extracted. Eight weeks later, one machined implant was placed in each mouse. Four weeks after osseointegration, the mice were divided into three groups: (a) control (C), (b) PI and (c) DM

AimTo describe the microbiological composition of subgingival dental plaque and molecular profile of gingival crevicular fluid (GCF) of periodontal furcation‐involved defects.Materials and MethodsFifty‐seven participants with periodontitis contributed with a degree II–III furcation involvement (FI), a non‐furcation (NF) periodontal defect and a periodontally healthy site (HS). Subgingival plaque was

AimThe aim of this analysis was to compare a clinical periodontal prognostic system and a developed and externally validated artificial intelligence (AI)‐based model for the prediction of tooth loss in periodontitis patients under supportive periodontal care (SPC) for 10 years.Materials and MethodsClinical and radiographic parameters were analysed to assign tooth prognosis with a tooth prognostic system

AimTo identify serum‐ and salivary‐derived inflammatory biomarkers of periodontitis progression and determine their response to non‐surgical treatment.Materials and MethodsPeriodontally healthy (H; n = 113) and periodontitis patients (P; n = 302) were monitored bi‐monthly for 1 year without therapy. Periodontitis patients were re‐examined 6 months after non‐surgical periodontal therapy (NSPT). Participants

AimTo update the competences and learning outcomes and their evaluation, educational methods and education quality assurance for the training of contemporary specialists in periodontology, including the impact of the 2018 Classification of Periodontal and Peri‐implant Diseases and Conditions (2018 Classification hereafter) and the European Federation of Periodontology (EFP) Clinical Practice Guidelines

AimOral hygiene‐related self‐efficacy (OHSE) describes one's confidence to successfully execute oral hygiene behaviour. The aim of this study was to investigate the long‐term course of OHSE in patients during initial periodontal therapy (IPT) and supportive periodontal therapy (SPT) and its association with clinical parameters.Materials and MethodsPatients diagnosed with periodontitis, undergoing either

AimThis study aimed to assess hard and soft tissue contour changes following micro crestal flap‐alveolar ridge preservation (MCF‐ARP) and natural healing (NH) in periodontally compromised molar extraction sites and to analyse the feasibility and need for bone augmentation during implant therapy.Materials and MethodsFifty‐six patients with 70 sites were randomized into two groups at the site level (35

The cover image is based on the Original Article Are periodontitis and psoriasis associated? A pre‐clinical murine model by Crystal Marrugant et al., https://doi.org/10.1111/jcpe.13996.image

The cover image is based on the Original Article The adjunctive effect of polydeoxyribonucleotide on bone formation in alveolar ridge preservation: A pre‐clinical in vivo study by Young‐Chang Ko et al., https://doi.org/10.1111/jcpe.13988.image

AimTo assess whether guided bone regeneration (GBR) treatment of peri‐implantitis‐related bony defects could improve healing compared to open flap debridement (OFD) at 36 months.Materials and MethodsIn a multi‐centre, randomized clinical trial, 32 individuals received OFD (control group [CG]) and 34 GBR treatment (test group [TG]). Radiographic defect fill (RDF), probing pocket depth (PPD), bleeding

Mendelian randomization (MR) is a flexible analytical tool that has been widely applied to strengthen causal inference in observational epidemiology and is now gaining attention in many areas including periodontal research. The interpretation of results drawn from MR is based on a series of assumptions, which can be unrealistic or difficult to meet faithfully in some settings. However, we argue that

AimTo compare the efficacy of non‐surgical re‐instrumentation (NSR) and papillary preservation flap (PPF) surgery at single‐rooted teeth with residual pockets.Materials and MethodsPatients with at least a residual pocket depth (PD ≥ 5 mm) after Steps I and II were enrolled and randomly assigned to receive NSR or PPF surgery. The primary outcome was PD reduction, and secondary outcomes were clinical

AimPeriodontitis is one of the most common oral diseases and a major cause of tooth loss in adults. Environmental pollution is closely associated with the prevalence of periodontitis. However, few studies have focused on the association between volatile organic compounds (VOCs) and periodontitis. This cross‐sectional study aims to examine whether exposure to VOCs is associated with periodontitis, based

AimDepression is prevalent among older adults. Although the number of missing teeth is considered to be associated with depression, the relationship between masticatory function, which is usually indicated by functional tooth units (FTUs), and depression in older adults remains unclear.Materials and MethodsThis study used data from the National Health and Nutrition Examination Survey (NHANES) 2009–2018

AimTo develop a nomogram‐based predictive model of tooth survival by comprehensively analysing clinical and radiographic risk factors of tooth loss (TL).Materials and MethodsIn this study, 3447 teeth of 131 subjects who underwent non‐surgical periodontal treatment were examined retrospectively within a mean follow‐up period of 11.6 years. The association of risk factors including clinical and radiographic

AimTo identify new biomarkers to detect untreated and treated periodontitis in gingival crevicular fluid (GCF) using sequential window acquisition of all theoretical mass spectra (SWATH‐MS).Materials and MethodsGCF samples were collected from 44 periodontally healthy subjects and 40 with periodontitis (Stages III–IV). In the latter, 25 improved clinically 2 months after treatment. Samples were analysed

AimTo investigate whether cardiovascular health (CVH) is associated with periodontitis.Materials and MethodsWe used data from the 2009 to 2014 National Health and Nutrition Examination Survey. We quantified CVH using Life's Essential 8, which includes four health behaviours (diet, smoking, physical activity and sleep) and four health factors (body mass index, blood cholesterol, glucose and pressure)

AimTo compare the subgingival microbiota of patients receiving supportive periodontal care (SPC) with and without subgingival instrumentation, over 2 years.Materials and MethodsThis study was a randomized clinical trial that included 62 participants (50.97 ± 9.26 years old; 40 females) who completed non‐surgical periodontal therapy. Participants were randomly assigned to receive oral prophylaxis with

AimTo evaluate the efficacy of the PerioRisk prognostic tool in implementing the effect of motivational interviewing (MI) on psychological outcomes and supragingival plaque control.Materials and MethodsParticipants underwent MI immediately after their first periodontal visit. According to a parallel‐arm, randomized study design, MI was performed with (RISK group) or without (CTR group) information

AimTo investigate the relationship and potential causality between biological ageing and periodontitis.Materials and MethodsWe obtained the National Health and Nutrition Examination Survey (NHANES) and genome‐wide association study (GWAS) summary statistics as well as single‐cell sequencing data. Multivariate regression analysis based on cross‐sectional data, Mendelian randomization (MR) and multi‐omics

AimTo investigate the associations between oral health and depression, anxiety and their comorbidity in the UK Biobank cohort.Materials and MethodsOral health problems were self‐reported at baseline. Symptoms of depression and anxiety were assessed using the Mental Health Questionnaire (PHQ‐4) in a cross‐sectional study. In the cohort study, diagnoses of depression and anxiety disorders were based

AimTo identify an optimized strategy for the large‐scale production of nanovesicles (NVs) that preserve the biological properties of exosomes (EXOs) for use in periodontal regeneration.Materials and MethodsNVs from dental follicle stem cells (DFSCs) were prepared through extrusion, and EXOs from DFSCs were isolated. The yield of both extruded NVs (eNVs) and EXOs were quantified through protein concentration

AimThe occurrence of periodontal diseases is still to be determined in large samples of major Brazilian cities. This study aimed to assess the periodontal status of adults from Curitiba, Paraná, Brazil, using periodontitis definitions by the Centers for Disease Control and Prevention and the American Academy of Periodontology (CDC/AAP) and the recently published ACES 2018 Classification Framework.Materials

AimTo study the use of a quasi‐experimental design to assess the effects of scaling reimbursement policies on the incidence of chronic‐periodontitis procedures.Materials and MethodsInterrupted time series analysis was used to compare the effects before and after policy implementation using data on the number of periodontitis‐related procedures from the Korean National Health Insurance Service‐National

AIM Cellular oxygen sensing mechanisms have been linked to periodontal condition, and levels of haemoglobin (Hb) (the main carrier of oxygen) can be used as a surrogate measure for hypoxia. We aimed to examine relations between Hb levels and key periodontal health parameters in a general population. MATERIALS AND METHODS The population comprised 1711 (47% male) subjects from the Northern Finland Birth

AIM To compare the clinical and radiographic outcomes of flapless procedure alone or in combination with enamel matrix derivatives (EMD) in the treatment of deep intrabony defects. MATERIALS AND METHODS Forty-six patients re-evaluated after non-surgical therapy were randomly assigned to the test (flapless with EMD) or control group (flapless alone). Clinical measurements were recorded pre-surgery and

AIM To explore the levels of neutrophil extracellular traps (NETs) in patients with periodontitis and examine their effects on keratinization, barrier function of human gingival keratinocytes (HGKs) and the associated mechanisms. MATERIALS AND METHODS Saliva, gingival crevicular fluid (GCF), clinical periodontal parameters and gingival specimens were collected from 10 healthy control subjects and 10

AIM The aim of this retrospective long-term follow-up of a 3-month RCT was to assess whether non-surgical peri-implantitis treatment with adjunctive systemic antibiotics influenced the need for additional surgical treatment. MATERIALS AND METHODS Patients enrolled in an aftercare programme following non-surgical peri-implantitis treatment, with or without systemic amoxicillin and metronidazole, were

AIM To evaluate the radiographic outcomes of lateral sinus floor elevation with simultaneous implant placement at sites without sinus membrane perforation (SMP) and sites with SMP managed with a resorbable membrane. MATERIALS AND METHODS One hundred and thirty-nine patients and 170 implants (56 perforation, 114 non-perforation) were included. Cone-beam computed tomography (CBCT) images were taken before

AIM To retrospectively compare two approaches for the adjunctive use of systemic antibiotics in non-surgical periodontal therapy: one based on the detection of Aggregatibacter actinomycetemcomitans (Aa) and the other on age and severity of periodontitis (Age & PPD). We also assessed the additional benefit of antibiotics in reducing the need for further surgical therapy in each group. MATERIALS AND

AimImpairment of masticatory function in elderly patients with terminal dentition due to stage IV periodontitis (TDS4P) may lead to lower nutritional intake. The study aimed to report the dietary intake and nutrition status of elderly patients with TDS4P and compare them with those of the elderly Chinese population and the Chinese Dietary Reference Intakes (DRIs).Materials and MethodsFifty‐one consecutive

AimThis prospective cohort study investigated the association between periodontal diseases (PDs) and all‐cause and cause‐specific mortality.Materials and MethodsWe utilized adult participants recruited from six National Health and Nutrition Examination Survey cycles (1999–2014) and linked mortality data from the National Death Index up to December 2019. Baseline clinical periodontal examinations were

AimRadiotherapy is associated with cell depletion and loss of blood supply, which are linked to compromised bone healing. However, the molecular events underlying these effects at the tissue–implant interface have not been fully elucidated. This study aimed to determine the major molecular mediators associated with compromised osseointegration due to previous exposure to radiation.Materials and MethodsTitanium

AimTo investigate the effects of high‐intensity interval training (HIIT) on periodontitis (PD) progression and behavioural outcomes.Materials and MethodsForty‐eight Wistar rats were divided into four groups: non‐trained (NT); non‐trained with PD; HIIT with PD; and HIIT. The HIIT protocol, involving daily treadmill sessions, spanned 8 weeks, with PD induced by ligature after the 6th week. Behavioural

AimThis study aimed to identify the risk factors for gingival invagination during orthodontic treatment after premolar extraction.Materials and MethodsThe medical records of 135 patients who had undergone interdental space closure after premolar extraction were collected, and cone beam computed tomography was performed to determine the presence of gingival invagination. The risk factors were examined

AimTo examine association between subgingival microbial signatures and levels of cognitive impairment in older adults.Materials and MethodsWe analysed subgingival plaque samples and 16S ribosomal RNA sequences for microbiota among 165 participants (normal controls [NCs]: 40, subjective cognitive decline [SCD]: 40, mild cognitive impairment [MCI]: 49 and dementia: 36).ResultsThe bacterial richness was

AimTo systematically identify, synthesize and critically summarize the available scientific evidence from randomized controlled trials (RCTs) regarding whether short (≤6 mm) perform as well as long (≥10 mm) implants regarding implant survival, marginal bone loss, and biologic and prosthetic complications in different clinical scenarios.Materials and MethodsCochrane Collaboration's risk of bias tool

AimThis study aimed to compare microbial and inflammatory profiles in periodontally/systemically healthy African American (AA) and Caucasian (C) individuals.Materials and MethodsThirty‐seven C and 46 AA aged from 5 to 25 years were evaluated regarding periodontal disease, caries, microbial subgingival profile via 16‐s sequencing, as well as salivary and gingival crevicular fluid (GCF) inflammatory

ObjectiveTo determine the accuracy of salivary active matrix metalloproteinase (aMMP)‐8 point‐of‐care test (POCT) for detecting periodontitis in adults, through meta‐analysis.Materials and MethodsDiagnostic studies evaluating the accuracy of salivary/oral rinse aMMP‐8 POCT for detecting periodontitis in adults, when compared with clinical examination, were considered eligible. A comprehensive search

AimThe oral microenvironment contributes to microbial composition and immune equilibrium. It is considered to be influenced by dietary habits. Phenylketonuria (PKU) patients, who follow a lifelong low‐protein diet, exhibit higher prevalence of oral diseases such as periodontitis, offering a suitable model to explore the interplay between diet, oral microbiota and oral health.Materials and MethodsWe