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Clinical Features Associated With Periodontal Case Misclassification by an Active Matrix Metalloproteinase‐8 Point‐of‐Care Oral Rinse Test J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-12 Mengning Bi, Yu Xie, Xiaoyu Yu, Hairui Li, George Pelekos, Lijian Jin, Yuan Li, Maurizio S. Tonetti
BackgroundThe diagnostic performance of active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care oral rinse test (POC‐ORT) for periodontitis needs to be improved because of its relatively low sensitivity. This study attempted to identify the clinical features associated with the misclassification of periodontal cases by the test.MethodThis work consisted of two cross‐sectional diagnostic accuracy studies
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Aesthetics and Patient‐Reported Outcomes in Periodontology and Implant Dentistry: Consensus Report J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-11 Maurizio Tonetti, Mariano Sanz, Francesco Cairo, Jose Nart, Iain Chapple, Mario Aimetti, Sofia Aroca, Gustavo Avila‐Ortiz, Juan Blanco, Antonio Bujaldón, Raffaele Cavalcanti, Pierpaolo Cortellini, Jan Cosyn, Monique Danser, Massimo de Sanctis, Jan Derks, Henrik Dommisch, Elena Figuero, Rodolfo Gianserra, Filippo Graziani, Søren Jepsen, Moritz Kebschull, France Lambert, Eduardo Montero, Nadja Naenni
BackgroundAesthetics and patient‐reported experiences (PREs) and outcomes (PROs) influence treatment choices, but have been largely overlooked in periodontology and implant dentistry. This consensus conference evaluated these factors by focusing on gingival recession defects (GRDs), immediate or early/delayed implant placement and peri‐implant buccal soft‐tissue dehiscences.MethodsThe workshop discussions
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Effect of Tooth Splinting on Clinical Outcomes following Periodontal Regenerative Therapy in Teeth with Mobility Degree 1 or 0: A Propensity Score‐Matched Analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-06 Risako Mikami, Miho Ishimaru, Koji Mizutani, Hidehiro Shioyama, Takanori Matsuura, Norio Aoyama, Tomonari Suda, Yukako Kusunoki, Kohei Takeda, Tatsuhiko Anzai, Kunihiko Takahashi, Koichiro Matsuo, Jun Aida, Yuichi Izumi, Akira Aoki, Takanori Iwata
AimThe evidence for tooth splinting during periodontal regenerative therapy is limited. We aimed to investigate the adjunctive benefits of tooth splinting on clinical outcomes.Materials and MethodsIn total, 194 intrabony defects in 126 participants were prospectively evaluated over three years following periodontal regenerative therapy with an enamel matrix derivative. Clinical attachment level (CAL)
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Risk Factors for Early Implant Failure Following Sinus Augmentation: A Multi‐Centre Nested Case–Control Study J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-05 Björn Bonsmann, Mohamed Abughalia, Constantin von See, Thomas Dietrich
AimTo evaluate the determinants of early implant failure after sinus augmentation (SA).Materials and MethodsWe conducted a nested case–control study of implants placed after SA between 2016 and 2021 in eight centres across Germany. We included a total of 129 implants that were lost within 12 months after placement (cases) and 273 implants that were not lost within 12 months (controls). Multivariable
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Microbial Complexes in Subgingival Plaque: A Bacterial Meta‐Taxonomic Study J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-05 Julien Santi‐Rocca, David F. Martín‐García, Iván Lorca‐Alonso, Sandra la González‐de la Fuente, Begoña Aguado, Mark Bonner, Véronique Amard, Pierre Amiot, Charlotte Bar, Vincent Berbon, Nefissa Berkani, Alix Burke, Ivonne Cartagena, Jean‐Michel Chatard, Céline Coutayar, Guillaume Depraz, Isabel Morales, Narcisa Popa, Stéphane Regniers, Thomas Rissoan, Catherine Robert, Arnaud Tremoureux, Marion Verdy
AimTo leverage technological advances to propose a more accurate representation of subgingival microbiota diversity and dynamics across health and disease, 25 years after the seminal and still authoritative contribution of Socransky and his colleagues.Materials and MethodsSubgingival plaque from 135 patients (41 healthy, 47 gingivitis, 47 periodontitis) was analysed by V3–V4 16S rRNA sequencing. Sequences
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Clinical and Patient‐Reported Outcomes in Grade III Furcations: A Randomized Feasibility Trial With SMART Design J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-05 Priya Bahal, Pasquale Santamaria, Zainab Malaki, Jeremy Redman, Luigi Nibali
AimTo assess the feasibility of applying sequential, multiple assignment, randomized trial (SMART) design in periodontology and to assess the response of grade III furcation‐involved molars to various treatments.MethodsA member of the public served as a co‐investigator. Twenty participants with at least one grade III furcation‐involved molar tooth were randomized to either non‐surgical periodontal
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Shotgun Metagenomics Identifies in a Cross‐Sectional Setting Improved Plaque Microbiome Biomarkers for Peri‐Implant Diseases J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-05 Paolo Ghensi, Vitor Heidrich, Davide Bazzani, Francesco Asnicar, Federica Armanini, Alberto Bertelle, Federico Dell'Acqua, Ester Dellasega, Romina Waldner, Daniela Vicentini, Mattia Bolzan, Lorenzo Trevisiol, Cristiano Tomasi, Edoardo Pasolli, Nicola Segata
AimThis observational study aimed to verify and improve the predictive value of plaque microbiome of patients with dental implant for peri‐implant diseases.Materials and MethodsPatients were included in one of the following study groups according to the health status of their dental implants: (a) healthy, (b) affected by mucositis and (c) affected by peri‐implantitis. From each patient, submucosal
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Long‐Term Prognosis of Teeth With Class II Furcation Involvement: A Retrospective Cohort Study J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-02 P. Eickholz, T. Cordis, B. Dannewitz, B. Pretzl, M. Schröder, N. Lingwal, N. El Sayed
ObjectiveTo evaluate the survival of teeth with class II furcation involvement (FI) ≥ 5 years after active periodontal treatment (APT) and to identify the prognostic factors.MethodsAll charts of patients having undergone APT at the Department of Periodontology of Goethe‐University Frankfurt, Germany, were screened for teeth with class II FI. APT had to be accomplished ≥ 5 years ago. Charts were analysed
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Periosteal Fenestration Procedure in Apically Positioned Flap Increases the Attached Mucosal Width: An In Vivo Experimental Study J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-06-02 Inpyo Hong, Seungho Jeong, Hae Jee Shin, Daniel S. Thoma, Franz J. Strauss, Jung‐Seok Lee
AimTo evaluate the efficacy of the apically positioned flap (APF) with periosteal fenestration in increasing the width of the masticatory mucosa (MM, including attached and keratinized mucosa) and to assess the histological properties of the MM gained through this technique.Materials and MethodsSix mongrel dogs were treated using a split‐mouth design, with APF alone (control) and APF with periosteal
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Operative Times, Costs and Patient‐Related Outcome Measures in Vertical Ridge Augmentation With Customised Reinforced PTFE Mesh Versus CAD/CAM Titanium Mesh: Secondary Analysis of a Randomised Clinical Trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-27 Alessandro Cucchi, Sofia Bettini, Lucia Tedeschi, Debora Franceschi, Istvan Urban, Antonino Fiorino, Giuseppe Corinaldesi
AimThis secondary analysis of a randomised clinical trial aimed to investigate vertical ridge augmentation (VRA) by comparing complication rates (primary outcome), times, costs and patient‐reported outcome measures (PROMs) between customised Ti‐reinforced PTFE mesh and customised CAD/CAM titanium mesh.Materials and MethodsPatients with vertical bone defects were randomly assigned to alveolar bone augmentation
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Microbial Markers for Diagnosis and Risk Assessment for Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-25 Nagihan Bostanci, Daniel Manoil, Wannes Van Holm, Georgios N. Belibasakis, Wim Teughels
AimTo examine the accuracy of microbiological biomarkers in diagnosing periodontal diseases, specifically addressing three focus questions: (FQ1) distinguishing health from disease; (FQ2) predicting disease progression; and (FQ3) assessing treatment outcomes.Materials and MethodsA PRISMA‐guided search in MEDLINE, EMBAS and WEB OF SCIENCE included cross‐sectional and longitudinal studies (e.g., randomised
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Differential Response to Non‐Surgical Periodontal Therapy Between Intrabony and Suprabony Defects: A Retrospective Analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-20 Alessandro Cuozzo, Mishika Arora, Lorenzo Marini, Joshua Hurley, Zainab Malaki, Jing Kang, Luca Ramaglia, Luigi Nibali
AimTo assess the clinical response to Non‐Surgical Periodontal Therapy (NSPT) between suprabony and intrabony defects.Materials and MethodsTotally 200 NSPT patients' records from the King's College London—Oral, Dental and Craniofacial Biobank were included. Periapical radiographs of sites with Periodontal Probing Depth (PPD) > 4 mm were assessed. Changes in periodontal measurements between baseline
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Exosomes Derived From Human Gingival Mesenchymal Stem Cells Induce Metabolic Reprogramming of Inflammatory Macrophages J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-19 Jialu Wang, Yingzhe Hu, Zhiguo Wang, Chun Fan, Ye Liu, Yutong Xie, Lubin Liu, Jingshu Yang, Quanchen Xu
AimTo investigate the influence and mechanism of exosomes derived from human gingival mesenchymal stem cells (GMSC‐Exo) regulating macrophage polarisation through metabolic reprogramming.Materials and MethodsHuman acute monocytic leukaemia cells (THP‐1)‐derived macrophages were treated with GMSC‐Exo or Porphyromonas gingivalis lipopolysaccharide (P.g‐LPS) in vitro. Metabolic inhibitors were used to
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A Randomized Controlled Study on the Treatment of Isolated Interdental Intrabony Defects Using the Modified Minimally Invasive Surgical Technique With or Without a Collagen‐Enriched Bovine‐Derived Xenograft: A 2‐Year Analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-19 Yuzhe Sun, Haidong Zhang, Churen Zhang, Xiaochi Chang, Hongqiao Zhao, Xiangyu Sun, Pierpaolo Cortellini, Kaining Liu, Jianxia Hou
AimThis study aimed to evaluate the efficacy of the modified minimally invasive surgical technique (M‐MIST) combined with a collagen‐enriched bovine‐derived xenograft (CEBDX) for the treatment of isolated interdental intrabony defects.Materials and MethodsThis is a randomized controlled trial including 40 isolated interdental intrabony defects in 40 patients. The test group received M‐MIST and CEBDX
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Clinical and Radiological Markers of Periodontal Status and Risk of Cognitive Decline and Incident Dementia J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-16 Sam Asher, Anna Liisa Suominen, Ruth Stephen, Tiia Ngandu, Seppo Koskinen, Alina Solomon
AimThere is evidence linking tooth loss with dementia; however, similar findings for periodontitis are inconclusive.Material and MethodsWe conducted cross‐sectional (N = 4046) and longitudinal analyses (N = 2769) on data from the Health 2000 and 2011 surveys for establishing any associations of periodontal health with baseline cognition, 11‐year risk of cognitive decline and 15‐year risk of incident
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Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase‐9 Levels in Periodontal Health and Diseases J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-15 Vusal Gurbanov, Ayla Öztürk, Fatma Doğruel, Hatice Saraçoğlu, Cevat Yazıcı
AimsTo investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase‐9 (MMP‐9) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis.Materials and MethodsThis prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34)
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Impact of Prolonged Fasting on the Oral Microbiome in Patients With Metabolic Syndrome: An Exploratory Secondary Analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-13 C. L. Pappe, S. Kleine Bardenhorst, K. Prior, N. Steckhan, A. Michalsen, B. Ehmke, H. Dommisch, D. Hagenfeld
AimTo evaluate the effect of prolonged fasting on the oral microbiome in patients with metabolic syndrome (MetS).Materials and MethodsThis follow‐up study evaluated changes in the oral microbiome in a sub‐cohort of 42 patients with MetS during prolonged fasting. Periodontal parameters such as bleeding on probing (BOP), plaque index (PI) and gingival crevicular fluid (GCF) measured in Periotron units
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Periodontal Inflammation and Serum Inflammatory Markers in Community‐Dwelling Older Adults in Japan: The Otassha Study J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-09 Masanori Iwasaki, Maki Shirobe, Yuki Ohara, Keiko Motokawa, Takashi Shida, Yoshiko Motohashi, Ayako Edahiro, Hisashi Kawai, Yoshinori Fujiwara, Kazushige Ihara, Yutaka Watanabe, Hiroyuki Sasai, Shuichi Obuchi, Hirohiko Hirano
AimTo investigate the associations between periodontal inflammation—as determined by the periodontal inflamed surface area (PISA)—and serum inflammatory markers in community‐dwelling older adults in Japan.Materials and MethodsThis cross‐sectional study included 470 adults (mean age: 73.1 years). The composite inflammatory marker z‐score (CIMZ) was calculated as the sum of the participants' individual
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Pre‐Emptive Analgesia for Periodontal and Implant‐Related Surgery: A Systematic Review and Meta‐Analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-08 Christos Gousias, Zainab Alsuwaiyan, Alissa Fial, Shengtong Han, Dimitris N. Tatakis, Vrisiis Kofina
ObjectiveThis systematic review aimed to answer the question: In patients undergoing periodontal and peri‐implant surgery, gingival augmentation, implant site development or placement, are pre‐emptive analgesics effective in controlling post‐operative pain compared with patients not receiving pre‐emptive medications?Materials and MethodsAfter comprehensive electronic and manual literature searches
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Evaluating the Performance and Implementation of the 2018 Classification of Periodontal Diseases: A Systematic Review and Survey J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-07 Nicola X. West, Alexander Gormley, Alexander J. Pollard, Rossana Izzetti, Crystal Marruganti, Filippo Graziani
AimTo evaluate the performance and implementation of the 2018 Classification of Periodontal Diseases for periodontitis through systematic review and survey methodology.Materials and MethodsA two‐part systematic review was conducted. Part 1 aimed, with descriptive statistics, to evaluate performance metrics of the 2018 Classification, including diagnostic accuracy, prognostic performance and examiner
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Capitalising on Tax Variation to Estimate the Effect of Alcohol Consumption on Edentulism J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-07 Sebastian‐Edgar Baumeister, Birte Holtfreter, Thomas Kocher, Gustavo G. Nascimento
AimTo estimate alcohol consumption's effect on edentulism using state alcohol taxes as an instrumental variable (IV).Material and MethodsAnalysis of 514,357 U.S. Behavioural Risk Factor Surveillance System participants (2003–2006, 2008, 2010, 2012) linked to state alcohol taxes. We used IV regression modelling to assess the relationship between alcohol consumption and edentulism, plus potential mediators
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Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-05 David Herrera, Maurizio S. Tonetti, Iain Chapple, Moritz Kebschull, Panos N. Papapanou, Anton Sculean, Loreto Abusleme, Mario Aimetti, Georgios Belibasakis, Juan Blanco, Nagihan Bostanci, Philippe Bouchard, Nurcan Buduneli, Elena Calciolari, Maria Clotilde Carra, Tali Chackartchi, Bettina Dannewitz, Monique Danser, Ke Deng, Jan Derks, Thomas Dietrich, Nicola Discepoli, Kimon Divaris, Henrik Dommisch
BackgroundThis Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impetus for the workshop, including the limited quality of available research on diagnostic tests, the rapid development of new technologies, the implementation of the
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Accuracy of Clinical Parameters in Predicting/Diagnosing Peri‐Implant Bone Loss J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-05-05 Mario Romandini, Cristina Lima, Miguel Moreno, Mariano Sanz
AimTo determine whether clinical parameters can serve as (i) predictive tools (before occurrence) and (ii) diagnostic tools (after occurrence) of peri‐implant bone loss.Materials and MethodsA representative cohort of 72 patients with 298 implants was evaluated at baseline and after a mean follow‐up period of 3.9 years. Peri‐implant bone loss > 1 mm between the two examinations represented the reference
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A Multi‐Centre Randomised Controlled Trial Comparing dPTFE Membrane to Collagen Membrane in Lateral Bone Augmentation at Single Sites in the Anterior Maxilla: 1‐Year Results J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-29 Matthijs Hindryckx, Thomas De Bruyckere, Stefanie De Buyser, Lorenz Seyssens, Retis Shtino, Faris Younes, Jan Cosyn
AimTo compare a dense polytetrafluoroethylene (dPTFE) membrane with a collagen membrane in guided bone regeneration for lateral bone augmentation at single sites in the anterior maxilla in terms of alveolar width, height, complications, need for additional therapy and implant outcomes.Materials and MethodsPatients with a class 4 defect at a single site in the anterior maxilla (15–25) were recruited
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Three‐Year Outcomes of Dental Implants With a Hybrid Surface Macro‐Design Placed in Patients With History of Periodontitis: A Randomised Clinical Trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-25 Benjamín Serrano, Ignacio Sanz‐Sánchez, Eduardo Montero, Mariano Sanz
AimThis randomised controlled trial (RCT) with a 3‐year follow‐up was aimed at assessing the clinical and radiographic outcomes of implants with either a hybrid or moderately rough macro‐surface design placed in patients with a history of periodontitis.Material and MethodsForty periodontitis subjects with a stable periodontal condition were included and randomly assigned to receive either a hybrid
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The Synergetic Effect of Periodontal Therapy and TNF‐α Inhibitor for the Treatment of Comorbid Periodontitis and Psoriasis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-25 Crystal Marruganti, Carlo Gaeta, Chiara Falciani, Elisa Cinotti, Pietro Rubegni, Mario Alovisi, Nicola Scotti, Andrea Baldi, Cristiana Bellan, Chiara Defraia, Elena Bertaggia, Fabio Fiorino, Silvia Valensin, Erika Bellini, Antonella De Rosa, Filippo Graziani, Francesco D'Aiuto, Simone Grandini
AimTo assess the adjunctive effect of periodontal therapy on psoriasis‐related outcomes in a combined experimental model of ligature‐induced periodontitis and Imiquimod (IMQ)‐induced psoriasis. Also, this experiment aimed to study the impact of TNF‐α inhibitors on the periodontium.MethodsFifty‐six C57/BL6J mice were randomly allocated to seven experimental groups: (a) control group (P–Pso–) with no
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Host Markers of Periodontal Diseases: Meta‐Analysis of Diagnostic Accuracy Studies J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-19 Mia Rakic, Elena Calciolari, Melissa M. Grant, Sandro Radovanovic, Nagihan Bostanci, Philip M. Preshaw
ObjectiveTo identify host markers with optimal diagnostic performance for clinical implementation in the diagnosis of periodontal diseases and prediction of future disease progression and/or disease resolution.Material and MethodsCross‐sectional and prospective studies with ≥ 20 participants per group, reporting diagnostic accuracy (e.g., area under the curve [AUC]) of host markers for periodontal
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Patient‐Centred Preferences for Autonomy and Information‐Seeking Among Periodontal Patients in Dental Decision Making J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-16 Ji‐Young Jung, Kyung‐A Ko, Franz J. Strauss, Jae‐Hong Lee, Jun‐Hewk Kim, Jung‐Seok Lee
Background and AimManaging periodontal disease often involves complex decisions involving multiple treatment options, and patient autonomy significantly influences this decision‐making process. This study aimed to characterise the autonomy and information‐seeking preferences among patients diagnosed with stage III/IV periodontitis, and to identify the factors influencing these preferences.Materials
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Macrophage Depletion Reduces Bone Loss and Alters Inflammatory Responses: A Mouse Peri‐Implantitis Model J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-16 Ofir Ginesin, Benjamin R. Coyac, Ofri Doppelt‐Flikshtain, Yaniv Mayer, Eran Gabay, Tal Berg, Yotam Bar‐On, Hadar Zigdon‐Giladi
AimTo evaluate the impact of macrophage depletion on bone loss and inflammatory responses in a mouse model of peri‐implantitis, assessing macrophage depletion potential as a therapeutic strategy.Materials and MethodsUsing 6‐week‐old male C57BL/6 mice, peri‐implantitis was induced by placing a silk ligature around osteointegrated dental implants. Mice were divided into three groups: Healthy control
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Early Buccal Bone Resorption in Areas With or Without Keratinized Tissue and Different Mucosal Thickness at Implants in Healed Sites: An Experimental Animal Study J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-16 Antonio Liñares, Hong Jin Tan, Fernando Muñoz, Dragana Rakasevic, Yago Leira, Juan Blanco
AimTo evaluate early buccal bone resorption (BBR) in areas with or without buccal keratinized tissue (KT), and different mucosal thickness (MT) following implant placement at healed sites.Materials and MethodsIn 9 beagle dogs, three months following the hemimaxilla third and fourth premolars extraction, full‐thickness flaps were elevated and two tissue‐level implants were inserted. Before suturing
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A New Method for Volumetric Analysis of Soft‐Tissue Changes Using Three‐Dimensional Imaging in Patients With Periodontitis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-16 Aleksandar Pupovac, Davor Kuiš, Ivana Mišković, Stjepan Špalj, Alexei Zhurov, Jelena Prpić
AimsTo quantify changes in soft‐tissue volume induced by non‐surgical periodontal therapy (NSPT) in patients with periodontitis and correlate them with clinical parameters and smoking. A new digital approach is investigated because standard periodontal clinical assessment methods are unable to accurately capture volumetric changes.Materials and MethodsThirty‐nine subjects with periodontitis aged 27–70
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Efficacy of Injectable Bone Fillers for Alveolar Ridge Preservation: A Histomorphometrical Analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-11 Frank Schwarz, Ausra Ramanauskaite, Karina Obreja, Jonas Lorenz, Robert Sader, Puria Parvini
AimTo assess the efficacy of injectable bone fillers for alveolar ridge preservation (ARP).Materials and MethodsThe mandibular premolars (P2, P3, P4) were bilaterally assigned to ARP in a total of n = 9 beagle dogs. Each P was decapitated and hemisected under preservation of the mesial (i.e., devitalization and filling with calcium hydroxide) and removal of the distal root. The resulting 6 extraction
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AI‐Driven Detection and Measurement of Keratinized Gingiva in Dental Photographs: Validation Using Reference Retainers J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-08 Ya‐Chi Chen, Ling Chen, Yu‐Lin Lai, Wei‐Ting Chang, Shyh‐Yuan Lee
AimTo evaluate a deep learning (DL) model for detecting keratinized gingiva (KG) in dental photographs and validate its clinical applicability using reference retainers for calibration.Materials and MethodsA total of 576 sextant photographs were selected from 32 subjects, each with three sets of photographs: iodine‐stained, unstained and line‐marked retainers. Relative keratinized gingiva width (rKGW)
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Genetic Biomarkers for Periodontal Diseases: A Systematic Review J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-08 H. Dommisch, D. Hoedke, E. M.‐C. Lu, A. Schäfer, G. Richter, J. Kang, L. Nibali
AimsTo identify genetic biomarkers that may be used in the diagnosis, prevention or management of different forms of periodontal disease.Materials and MethodsFollowing protocol registration and PICOTS (patient, intervention, comparison, outcome, time, studies) questions, a systematic search of the literature was conducted (PudMed, Ovid), resulting in 1592 papers screened by two reviewers. Diagnostic
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A Real‐World Evidence Study Evaluating Oral‐Health‐Related Quality of Life Following the Use of Anti‐Sensitivity Toothpaste for Self‐Reported Dentine Hypersensitivity Management J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-03 Roberta Grimaldi, Sarah R. Baker, Parth Shah, Edwin Sanchez, Gilbert Shanga, Paola R. Gomez‐Pereira, Charlie R. Parkinson
AimsTo evaluate the impact of an anti‐sensitivity toothpaste on the oral‐health‐related quality of life (OHrQoL) in a real‐world (RW) setting.Materials and MethodsThis was a decentralised, prospective, 24‐week, open‐label study in participants with self‐reported dentine hypersensitivity (DH). A total of 655 enrolled participants used a 5% potassium nitrate toothpaste per label instructions and completed
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Cover Image J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-30 Istvan A. Urban, Matteo Serroni, Debora R. Dias, Zoltán Baráth, Andras Forster, Tiago G. Araújo, Muhammad H. A. Saleh, Alessandro Cucchi, Andrea Ravidà
The cover image is based on the article Impact of Collagen Membrane in Vertical Ridge Augmentation Using Ti‐Reinforced PTFE Mesh: A Randomised Controlled Trial by Istvan A. Urban et al., https://doi.org/10.1111/jcpe.14129. image
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Systemic Azithromycin as an Adjunct to Non‐Surgical Subgingival Instrumentation in the Treatment of Stage III/IV, Grade C Periodontitis: 12‐Month Clinical, Microbiological and Cytokine Results of a Randomised Controlled Trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-24 Srinivas Sulugodu Ramachandra, Valerie Woodford, Pingping Han, Ryan S. B. Lee, Sašo Ivanovski
AimTo evaluate the clinical, microbial and cytokine changes following the use of oral azithromycin as an adjunct to non‐surgical subgingival instrumentation (NSI) in stage III/IV, grade C periodontitis through a triple‐blind, parallel‐armed, randomised controlled trial.Material and MethodsA total of 52 patients with stage III/IV grade C periodontitis were randomly allocated to two groups receiving
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Emerging Applications of Digital Technologies for Periodontal Screening, Diagnosis and Prognosis in the Dental Setting J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-19 Roberto Farina, Anna Simonelli, Leonardo Trombelli, Johanna B. Ettmayer, Jan L. Schmid, Christoph A. Ramseier
AimTo comprehensively review digital technologies (including artificial intelligence, AI) for periodontal screening, diagnosis and prognosis in the dental setting, focusing on accuracy metrics.Materials and MethodsTwo separate literature searches were conducted for periodontal screening and diagnosis (part I, scoping review) and prognosis (part II, systematic approach). PubMed, Scopus and Embase databases
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Methods for Clinical Assessment in Periodontal Diagnostics: A Systematic Review J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-17 I. H. Stødle, J.‐C. Imber, S. V. Shanbhag, G. E. Salvi, A. Verket, A. Stähli
AimThis systematic review aimed to answer the following PECOS questions: In human subjects with untreated periodontitis (Q1) or enrolled in supportive periodontal care (SPC) (Q2) (P), are there clinical assessment methods (E) other than the contemporary manual probe (C) that increase diagnostic accuracy or reliability when examining/screening for periodontitis (Q1) or when monitoring disease stability
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Changes in Osseous Morphology Following Non‐Surgical Periodontal Therapy: A Possible Paradigm Shift for the Treatment of Intrabony Defects? J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-13 Luigi Nibali, Pierpaolo Cortellini
Sub‐gingival non‐surgical periodontal therapy (NSPT) constitutes step 2 of periodontal therapy, aiming to disrupt the subgingival microbial biofilm and resolve or reduce inflammation of the supracrestal periodontal tissues. A plethora of original studies and reviews have been published over several decades, highlighting its fundamental importance in periodontal therapy and in tooth survival. Evidence
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Alcohol Consumption, Risk of Periodontitis and Change of Periodontal Parameters in a Population‐Based Cohort Study J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-13 Sebastian‐Edgar Baumeister, Janka Schössow, Gustavo G. Nascimento, Henry Völzke, Thomas Kocher, Birte Holtfreter
AimTo investigate the association of alcohol consumption with periodontitis risk and change in periodontal parameters over time.MethodsUsing data from 1285 participants of two population cohort studies embedded in the Study of Health in Pomerania, we associated baseline average alcohol consumption with incident periodontitis measured after a median follow‐up time of 5.0 years, adjusting for confounding
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Microbiological, Inflammatory and Clinical Outcome of Citric Acid Passivated Definitive Abutments: Interim 12‐Month Results From a Randomised Controlled Clinical Trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-12 Javi Vilarrasa, Carlos Pereira Couto, Gerard Àlvarez, Neus Carrió, Javier Gil, Vanessa Blanc, José Nart
AimTo assess the efficacy of citric acid passivation on implant abutments by evaluating their impact on bacterial load, microbiome composition, inflammatory response, and clinical and radiographic outcomes compared with control abutments over a 12‐month follow‐up period.MethodsImplants were placed subcrestally in the posterior sextants and randomly assigned to receive a 2‐mm high definitive abutment
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Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three‐Arm Clinical Trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-12 C. L. Pappe, J. Maetschker, S. Dujardin, B. Peters, O. Pivovarova‐Ramich, F. Kandil, A. Michalsen, C. Breinlinger, N. Steckhan, D. Koppold, H. Dommisch
AimTo evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time‐restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.Material and MethodsAll participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular
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Periodontitis History Shapes the Early Peri‐Implant Microbiome Formation: A Metagenomic Analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-11 Miao Wang, Yi Bing Liu, Wai Man Tong, Wai Keung Leung, Long Long He, Xin Xu, Dan Xu, Qin Zhou
AimThis study aims to investigate the early alterations in microbiome construction and succession around dental implants in both periodontally healthy individuals and patients with a history of periodontitis during the first month after implant–crown placement.Materials and MethodsNinety‐five subgingival plaque samples were collected from 10 periodontally compromised patients (PCP) and nine periodontally
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Multi‐Centre External Validation of a Nomogram for 10‐Year Periodontal Tooth Loss Prediction J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-10 Matteo Serroni, Andrea Ravidà, Pasquale Santamaria, Debora R. Dias, Guo‐Liang Cheng, Samar Shaikh, Nima David Natanzi, Muhammad H. A. Saleh, Luigi Nibali, Giuseppe Troiano
AimsTo externally validate the potential applicability of the 2018 classification of periodontal diseases as a risk assessment tool, through the use of a nomogram built on a multivariate predictor model.Materials and MethodsData from 459 patients with periodontitis, across four cohorts (three in the United States, and one in the United Kingdom), were retrospectively analysed. After staging and grading
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Hyperuricemia Exacerbates Experimental Periodontitis via Uric Acid‐Induced Periodontal Inflammation and Oxidative Stress J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-02-20 Zhicong Wu, Li Zhao, Yi Guo, Chuyin Lin, Peipei Lu, Qian He, Yinghong Zhou, Xinhong Wang, Ting Yu
AimTo investigate the effects of hyperuricemia on periodontitis and the underlying mechanisms by establishing combined animal and cell models.MethodsA hyperuricemia mouse model was established by potassium oxonate injection, with sodium carboxymethylcellulose treatment serving as controls. Both models were treated with or without periodontitis induction (n = 10/group). RAW264.7 macrophages and THP‐1‐derived
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Comparison of Ultrasonography, CBCT, Transgingival Probing, Colour‐Coded and Periodontal Probe Transparency With Histological Gingival Thickness: A Diagnostic Accuracy Study Revisiting Thick Versus Thin Gingiva J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-02-20 Hamoun Sabri, Paolo Nava, Parham Hazrati, Abdusalam Alrmali, Pablo Galindo‐Fernandez, Muhammad H. A. Saleh, Javier Calatrava, Shayan Barootchi, Lorenzo Tavelli, Hom‐Lay Wang
AimTo assess the reliability of ultrasonographic, cone beam computed tomographic (CBCT), probe transparency and transgingival probing (TGP) methods in evaluating gingival thickness (GT), compared with the gold standard histological assessment.MethodsSixteen fresh cadaver heads with intact gingivae were used. The sequence for GT measurement included CBCT, ultrasonography, probe transparency, TGP and
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