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A multi‐centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the buccal aspect of single implants: 3‐Year results J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-15 Lenz Surdiacourt, Véronique Christiaens, Thomas De Bruyckere, Stefanie De Buyser, Aryan Eghbali, Stijn Vervaeke, Faris Younes, Jan Cosyn
AimTo compare connective tissue graft (CTG) with collagen matrix (CMX) in terms of increase in buccal soft tissue profile (BSP) when applied at single implant sites.Materials and MethodsPatients with a single tooth gap in the anterior maxilla and horizontal mucosa defect were enrolled in a multi‐centre randomized controlled trial. All were fully healed sites with a bucco‐palatal bone dimension of at
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Effects of implant placement timing and type of soft‐tissue grafting on histological and histomorphometric outcomes in a preclinical canine model J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-14 Hyun‐Chang Lim, Kwang‐Seok Lee, Seung‐Yun Shin, Ronald E. Jung, Ui‐Won Jung, Daniel S. Thoma
AimTo determine the effects of implant timing and type of soft‐tissue grafting on histological and histomorphometric outcomes in a preclinical model.Materials and MethodsFour implant placement protocols were randomly applied at the mesial root sites of the third and fourth mandibular premolars in 10 mongrel dogs: immediate placement (group IP), early placement (group EP), delayed placement with/without
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Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-12 Sam Asher, Anna Liisa Suominen, Ruth Stephen, Tiia Ngandu, Seppo Koskinen, Alina Solomon
AimEmerging evidence suggests association of tooth loss with impaired cognition. However, the differential effects of anterior versus posterior tooth loss, occlusal support loss and chewing ability are not considered comprehensively.Materials and MethodsWe conducted cross‐sectional (N = 4036) and longitudinal analyses (N = 2787) on data from Health 2000 and 2011 Surveys for associations of posterior
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Effect of non‐surgical periodontal therapy on salivary histone deacetylases expression: A prospective clinical study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-12 Andrew Liaw, Chun Liu, Mark Bartold, Sašo Ivanovski, Pingping Han
AimTo evaluate the effect of non‐surgical periodontal therapy (NSPT) on salivary histone deacetylases (HDACs) gene expression in patients with Stage III–IV periodontitis at baseline and at 3 and 6 months post NSPT treatment.Materials and MethodsTwenty patients completed the study. Periodontitis (as well as the corresponding staging and grading) was diagnosed according to the 2017 World Workshop Classification
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Enhanced immunomodulation and periodontal regeneration efficacy of subgingivally delivered progranulin‐loaded hydrogel as an adjunct to non‐surgical treatment for Class II furcation involvement in dogs J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-11 Wenchuan Liu, Aimei Song, Yixi Wu, Pizhang Gong, Jingjing Zhao, Liguo Zhang, Xinyang Liu, Ruwei Wang, Hongmei Guo, Pishan Yang
AimTo evaluate the effect of subgingival delivery of progranulin (PGRN)/gelatin methacryloyl (GelMA) complex as an adjunct to scaling and root planing (SRP) on an experimental periodontitis dog model with Class II furcation involvement (FI).Materials and MethodsA Class II FI model was established, and the defects were divided into four treatment groups: (a) no treatment (control); (b) SRP; (c) SRP
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Sugar‐sweetened beverage consumption and periodontitis among adults: A population‐based cross‐sectional study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-08 Silas Alves‐Costa, Gustavo G. Nascimento, Marco A. Peres, Huihua Li, Susilena Arouche Costa, Cecilia Claudia Costa Ribeiro, Fábio Renato Manzolli Leite
AimInvestigating the association between sugar‐sweetened beverages (SSBs) and periodontitis and whether the awareness of diabetes modifies this relationship.Materials and MethodsCross‐sectional analysis was conducted using the National Health and Nutrition Examination Survey (NHANES III) data involving US adults aged 30–50. Periodontitis was classified according to the Centers for Disease Control and
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Immediate implant placement with immediate or delayed provisionalization in the maxillary aesthetic zone: A 10‐year randomized trial J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-08 Vincent J. J. Donker, Gerry M. Raghoebar, Kirsten W. Slagter, Diederik F. M. Hentenaar, Arjan Vissink, Henny J. A. Meijer
AimTo compare the marginal bone level of immediately placed implants, with either immediate or delayed provisionalization (IP or DP), in the maxillary aesthetic zone after 10 years of function.Materials and MethodsParticipants with a failing tooth in the maxillary aesthetic zone were randomly assigned to immediate implant placement with either IP (n = 20) or DP (n = 20) after primary wound closure
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Improvement of periodontal parameters following intensive diabetes care and supragingival dental prophylaxis in patients with type 2 diabetes: A prospective cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-07 Koji Mizutani, Isao Minami, Risako Mikami, Daisuke Kido, Kohei Takeda, Keita Nakagawa, Shu Takemura, Natsumi Saito, Hiromi Kominato, Eri Sakaniwa, Kuniha Konuma, Yuichi Izumi, Yoshihiro Ogawa, Takanori Iwata
AimThis study aimed to investigate the effects of diabetes care on periodontal inflammation.Materials and MethodsThis prospective cohort study included 51 Japanese patients with type 2 diabetes who underwent intensive diabetes care including educational hospitalization and regular outpatient treatment for 6 months. Dental prophylaxis without subgingival scaling was provided three times during the observational
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Prevalence of self‐reported severe periodontitis: Data from the population‐based CONSTANCES cohort J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-02 Emmanuel Wiernik, Adeline Renuy, Sofiane Kab, Philippe Gabriel Steg, Marcel Goldberg, Marie Zins, Giuseppina Caligiuri, Philippe Bouchard, Maria Clotilde Carra
AimTo assess the prevalence of severe periodontitis based on the population‐based CONSTANCES cohort using a validated self‐reported questionnaire.Materials and MethodsIndividuals were selected from the adult population in France using a random sampling scheme. Analyses were restricted to those invited in 2013–2014 who completed the periodontal health questionnaire at the 2017 follow‐up. The risk of
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Periodontitis is associated with decreased experimental pressure pain tolerance: The Tromsø Study 2015–2016 J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-01 Elin Hadler‐Olsen, Natalia Petrenya, Birgitta Jönsson, Ólöf Anna Steingrímsdóttir, Audun Stubhaug, Christopher Sivert Nielsen
AimTo assess the relationship between periodontitis and experimental pain tolerance.Materials and MethodsParticipants from the population‐based seventh survey of the Tromsø Study with data on periodontitis were included (n = 3666, 40–84 years old, 51.6% women). Pain tolerance was assessed through (i) pressure pain tolerance (PPT) test with a computerized cuff pressure algometry on the leg, and (ii)
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Gingipains may be one of the key virulence factors of Porphyromonas gingivalis to impair cognition and enhance blood–brain barrier permeability: An animal study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-28 Fulong Li, Chunliang Ma, Shuang Lei, Yaping Pan, Li Lin, Chunling Pan, Qian Li, Fengxue Geng, Dongyu Min, Xiaolin Tang
AimBlood–brain barrier (BBB) disorder is one of the early findings in cognitive impairments. We have recently found that Porphyromonas gingivalis bacteraemia can cause cognitive impairment and increased BBB permeability. This study aimed to find out the possible key virulence factors of P. gingivalis contributing to the pathological process.Materials and MethodsC57/BL6 mice were infected with P. gingivalis
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Tooth loss during supportive periodontal care: A prospective study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-27 Fatemah Hasan, Antonio Magan‐Fernandez, Aliye Akcalı, Chuanming Sun, Nikos Donos, Luigi Nibali
AimTo assess periodontal stability and the association between tooth‐ and patient‐related factors and tooth loss during supportive periodontal care (SPC).Materials and MethodsA prospective observational study was carried out on previously treated periodontitis patients followed up for 5 years in SPC. The risk profile (low, moderate, high) of each patient based on periodontal risk assessment (PRA) scoring
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LIGHT protein: A novel gingival crevicular fluid biomarker associated with increased probing depth after periodontal surgery J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-23 Anders Esberg, Elin Kindstedt, Catrine Isehed, Susanne Lindquist, Anders Holmlund, Pernilla Lundberg
AimTo evaluate the protein profiles in gingival crevicular fluid (GCF) in relation to clinical outcomes after periodontal surgery and examine if any selected proteins affect the mRNA expression of pro‐inflammatory cytokines in human gingival fibroblasts.Materials and MethodsThis exploratory study included 21 consecutive patients with periodontitis. GCF was collected, and the protein pattern (n = 92)
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Periodontal pockets: Predictors for site‐related worsening after non‐surgical therapy—A long‐term retrospective cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-22 Marco M. Herz, Nina Hoffmann, Sandra Braun, Stefan Lachmann, Valentin Bartha, Hari Petsos
AimTo evaluate site‐related changes in periodontal pocket depth (PPD) after non‐surgical periodontal therapy and to identify predictors for PPD changes in a retrospective patient data analysis.Materials and MethodsPPD, clinical attachment level, bleeding on probing, tooth mobility (TM), furcation involvement (FI), abutment status, adherence to supportive periodontal care (SPC) and SPC follow‐ups were
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ACES: A new framework for the application of the 2018 periodontal status classification scheme to epidemiological survey data J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-22 Birte Holtfreter, Kathrin Kuhr, Katrin Borof, Maurizio S. Tonetti, Mariano Sanz, Kenneth Kornman, Søren Jepsen, Ghazal Aarabi, Henry Völzke, Thomas Kocher, Joachim Krois, Panos N. Papapanou
AimTo propose a framework for consistently applying the 2018 periodontal status classification scheme to epidemiological surveys (Application of the 2018 periodontal status Classification to Epidemiological Survey data, ACES).Proposed FrameworkWe specified data requirements and workflows for either completed or planned epidemiological surveys, utilizing commonly collected measures of periodontal status
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Isolation, identification and osteogenic capability analysis of mesenchymal stem cells derived from different layers of human maxillary sinus membrane J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-21 Huixin Lv, Jing Xu, Yihan Wang, Xiuyu Liu, Sheng Chen, Jingxia Chen, Jingjie Zhai, Yanmin Zhou
AimTo discover the populations of mesenchymal stem cells (MSCs) derived from different layers of human maxillary sinus membrane (hMSM) and evaluate their osteogenic capability.Materials and MethodshMSM was isolated into a monolayer using the combined method of physical separation and enzymatic digestion. The localization of MSCs in hMSM was performed by immunohistological staining and other techniques
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Flapless early implant placement into the uncalcified provisional matrix—Does it lead to osseointegration of the implant? A preclinical study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-14 Jin-Young Park, Yoon-Hee Kwon, Young Woo Song, Jae-Kook Cha, Ui-Won Jung, Ronald E. Jung, Daniel S. Thoma
To test whether early implant placement into the extraction socket containing an uncalcified provisional matrix leads to successful osseointegration and stable marginal bone levels.
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The potential causal path between periodontitis stage diagnosis and vegetable consumption is mediated by loss of posterior functional tooth units and masticatory function J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-13 Xinyu Wu, Jie Shen, Xiao Zhang, Beilei Liu, Min Liu, Junyu Shi, Shujiao Qian, Geng Zong, Hongchang Lai, Changzheng Yuan, Maurizio S. Tonetti
Emerging evidence points to a two-way relationship between periodontitis and dietary choices and, thus, nutrition. This study aimed to assess the potential cause–effect relationship between the periodontitis stage, loss of functional tooth units (FTUs), masticatory function, and intake of different food groups using path analysis.
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Computational analysis of curcumin-mediated alleviation of inflammation in periodontitis patients with experimental validation in mice J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-13 Danfeng Shen, Kamoran Tuerhong, Qi Huang, Kehao Liu, Yuzhou Li, Sheng Yang
Using network pharmacology and experimental validation to explore the therapeutic efficacy and mechanism of curcumin (Cur) in periodontitis treatment.
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Clinical attachment loss is cross-sectionally associated with elevated glucose among adults without diabetes J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-11 Hamdi S. Adam, Rebecca Molinsky, Bruno Bohn, Sumith Roy, Michael Rosenbaum, Bruce Paster, Melana Yuzefpolskaya, Paolo C. Colombo, Panos N. Papapanou, Moïse Desvarieux, David R. Jacobs, Ryan T. Demmer
We investigated whether periodontal measures are cross-sectionally associated with prediabetes and cardiometabolic biomarkers among non-diabetic younger adults.
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The efficacy of combining adjuvants with non-surgical periodontal therapy in individuals with type 2 diabetes: A Bayesian network meta-analysis J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-11 Fabrício Batistin Zanatta, Raquel Pippi Antoniazzi, Leandro Machado Oliveira, Adam D. Lietzan, Patricia A. Miguez, Cristiano Susin
This Bayesian network meta-analysis of randomized controlled trials assessed the effect of adjuvant periodontal treatment in both periodontal and HbA1c outcomes in adult individuals with type 2 diabetes (T2DM).
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Tooth loss mediates the association between smoking and an increased risk of dementia among older adults: The JAGES prospective cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-07 Taro Kusama, Kenji Takeuchi, Sakura Kiuchi, Yudai Tamada, Takahiro Tabuchi, Ken Osaka
Tooth loss has various causes; however, its cause-specific effects on health outcomes remain unclear. This study evaluated whether the association between past/current smoking and risk of dementia was mediated by tooth loss.
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The survival of periodontally treated molars in long-term maintenance: A systematic review and meta-analysis J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-05 Xiao Chen, Chunmei Xu, Yafei Wu, Lei Zhao
This systematic review and meta-analysis aimed to determine the survival of periodontally treated molars during maintenance care and identify the risk factors associated with molar loss among patients with periodontitis who received professional periodontal therapy and maintenance.
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Randomized controlled multi-centre study comparing shorter dental implants (6 mm) to longer dental implants (11–15 mm) in combination with sinus floor elevation procedures: 10-year data J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-31 Daniel S. Thoma, Robert Haas, Katarzyna Sporniak-Tutak, Abel Garcia, Thomas D. Taylor, Marcin Tutak, Veronika Pohl, Christoph H. F. Hämmerle
To compare implant survival and complication rates between shorter and standard-length implants with sinus augmentation and restored with single crowns, at 10 years of loading.
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Long-term exposure to ambient fine particulate matter and periodontitis: An observational study using nationally representative survey data J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-24 Wenjing Li, Na Li, Zhisheng Liang, Xingduo Hou, Yan Si, Xing Wang, Xiping Feng, Baojun Tai, Deyu Hu, Huancai Lin, Bo Wang, Chunxiao Wang, Shuguo Zheng, Xuenan Liu, Wensheng Rong, Weijian Wang, Shengzhi Sun, Huanxing Meng, Zhenyu Zhang
The rising prevalence of periodontitis imposes substantial burdens on individuals and society. Identifying environmental risk factors for periodontitis may contribute to tackling the global public health burden of it. This study aimed to assess the association between long-term exposure to PM2.5 and periodontitis in a nationally representative population from China.
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Augmentation of keratinized tissue using autogenous soft-tissue grafts and collagen-based soft-tissue substitutes at teeth and dental implants: Histological findings in a pilot pre-clinical study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-24 Hyun-Chang Lim, Franz J. Strauss, Seung-Il Shin, Ronald E. Jung, Ui-Won Jung, Daniel S. Thoma
To histomorphometrically assess three treatment modalities for gaining keratinized tissue (KT) at teeth and at dental implants.
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Arrestin beta-2 deficiency exacerbates periodontal inflammation by mediating activating transcription factor 6 activation and abnormal remodelling of the extracellular matrix J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-24 Meiting Feng, Ruiling Wang, Li Deng, Yanan Yang, Siying Xia, Feng Liu, Lijun Luo
To investigate the specific role of arrestin beta-2 (ARRB2) in the progression of periodontitis and the underlying mechanisms.
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Clinical outcomes and risk factors analysis of dental implants inserted with lateral maxillary sinus floor augmentation: A 3- to 8-year retrospective study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-21 Liefen Zhang, Chuan Zhou, Jimin Jiang, Xiaoyu Chen, Yaoqiong Wang, Antian Xu, Fuming He
To evaluate the 3- to 8-year outcomes of dental implants placed with lateral sinus floor augmentation (LSFA) and to identify factors affecting implant survival.
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Periodontal disease prevalence and oral hygiene status of adults with cystic fibrosis: A case–control study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-17 Niamh Coffey, Fiona O'Leary, Francis Burke, Laura Kirwan, Paul O'Regan, Barry Plant, Anthony Roberts, Martina Hayes
To investigate the prevalence of gingivitis and periodontitis, and the oral hygiene status of adults with cystic fibrosis (CF) in the Republic of Ireland.
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Single immediate implant placement in the maxillary aesthetic zone with and without connective tissue grafting: Results of a 5-year randomized controlled trial J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-16 Elise G. Zuiderveld, Henny J. A. Meijer, Barzi Gareb, Arjan Vissink, Gerry M. Raghoebar
To assess the 5-year effects of grafting connective tissue while undertaking single immediate implant placement and provisionalization at the mid-buccal mucosa level (MBML). Secondary outcomes were buccal bone wall thickness (BBT), marginal bone level (MBL) and patient satisfaction.
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Development and validation of a rule-based algorithm to identify periodontal diagnosis using structured electronic health record data J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-11 Bunmi Tokede, Ryan Brandon, Chun-Teh Lee, Guo-Hao Lin, Joel White, Alfa Yansane, Xiaoqian Jiang, Elsbeth Kalenderian, Muhammad Walji
To develop and validate an automated electronic health record (EHR)-based algorithm to suggest a periodontal diagnosis based on the 2017 World Workshop on the Classification of Periodontal Diseases and Conditions.
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Contribution of individual and accumulation in social determinants of health underlying gender disparities in periodontitis in a representative US population: A cross-sectional NHANES study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-10 Jing-Hong Liang, Mei-Ling Liu, Ying-Qi Pu, Cong Wang, Shan Huang, Nan Jiang, Li-Xin Hu, Yu-Shan Zhang, Zhao-Huan Gui, Xue-Ya Pu, Shao-Yi Huang, Ya-Jun Chen
To examine the impact of both individual and cumulative social determinants of health (SDoH) on the likelihood of developing periodontitis, while also exploring any gender disparities in this relationship.
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Periodontitis and hypertension are linked through systemic inflammation: A 5-year longitudinal study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-09 Kitti Torrungruang, Prin Vathesatogkit, Rangsini Mahanonda, Lalitsara Thienpramuk
To investigate the associations between periodontitis and hypertension and potential mediation via systemic inflammation through a 5-year longitudinal study.
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Periodontal disease in patients with WHIM syndrome J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-07 Laurie Brenchley, David H. McDermott, Pamela J. Gardner, Lakmali M. Silva, Ji-Liang Gao, Elena Cho, Daniel Velez, Niki M. Moutsopoulos, Philip M. Murphy, David Fraser
WHIM (warts, hypogammaglobulinaemia, infections and myelokathexis) syndrome is a rare combined primary immunodeficiency disease caused by gain-of-function (GOF) mutations in the chemokine receptor CXCR4 and includes severe neutropenia as a common feature. Neutropenia is a known risk factor for periodontitis; however, a detailed periodontal evaluation of a WHIM syndrome cohort is lacking. This study
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Effect of periodontal therapy on glycaemic control in type 2 diabetes J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-03 Misuzu Sato, Sachiko Ono, Hayato Yamana, Akira Okada, Miho Ishimaru, Yosuke Ono, Masanori Iwasaki, Jun Aida, Hideo Yasunaga
This study aimed to elucidate the impact of periodontal therapy on glycaemic control in individuals with type 2 diabetes and various baseline blood glucose levels using a large-scale claims database from Japan.
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NLRP3-mediated periodontal ligament cell pyroptosis promotes root resorption J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-01-01 Xinyi Li, Xinrui Men, Ling Ji, Xinyi Chen, Shushu He, Ping Zhang, Song Chen
To investigate the mechanisms by which periodontal ligament cells (PDLCs) convert biomechanical stimulation into inflammatory microenvironment inducing root resorption (RR).
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Association between polycyclic aromatic hydrocarbons and periodontitis: Results from a large population-based study J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-30 Yuxuan Wu, Han Yang, Weiqiu Jin, Yuying Wu, Yiming Yu, Qiansi Chen, Baochang He, Fuhua Yan, Yanfen Li, Fa Chen
To explore the association between polycyclic aromatic hydrocarbons (PAHs) (measured using urinary metabolites) and periodontitis using data from the National Health and Nutrition Examination Survey 2009–2014.
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Dietary inflammatory index in relation to salivary cytokine concentrations and periodontitis: A cross-sectional analysis J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-29 Sanna Syrjäläinen, Satu Männistö, Eija Könönen, Pirkko Pussinen, Mervi Gürsoy, Anna Liisa Suominen, Pekka Jousilahti, Ulvi Kahraman Gürsoy
To examine the associations of dietary inflammatory index (DII) with salivary cytokine concentrations and periodontitis after controlling for body mass index (BMI), socio-demographic factors and lifestyle.
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Cross-sectional association between severe periodontitis and diabetes mellitus: A nation-wide cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-23 Eduardo Montero, Rocío Bujaldón, Eduard Montanya, Alfonso L. Calle-Pascual, Gemma Rojo-Martínez, Luis Castaño, Josep Franch-Nadal, Elías Delgado, Felipe Chaves, Bettina Alonso, Mariano Sanz, David Herrera
To evaluate the cross-sectional association between severe periodontitis and diabetes mellitus (DM), in a representative sample of Spanish population.
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A genome-wide association study meta-analysis in a European sample of stage III/IV grade C periodontitis patients ≤35 years of age identifies new risk loci J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-23 Silvia Diz De Almeida, Gesa M. Richter, Alicia de Coo, Søren Jepsen, Ines Kapferer-Seebacher, Henrik Dommisch, Klaus Berger, Matthias Laudes, Wolfgang Lieb, Bruno G. Loos, Nathalie van der Velde, Natasja van Schoor, Lisette de Groot, , Juan Blanco, Angel Carracedo, Raquel Cruz, Arne S. Schaefer
Few genome-wide association studies (GWAS) have been conducted for severe forms of periodontitis (stage III/IV grade C), and the number of known risk genes is scarce. To identify further genetic risk variants to improve the understanding of the disease aetiology, a GWAS meta-analysis in cases with a diagnosis at ≤35 years of age was performed.
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Interdental cleaning aids are beneficial for oral health at 7-year follow-up: Results from the Study of Health in Pomerania (SHIP-TREND) J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-20 Birte Holtfreter, Elena Conrad, Thomas Kocher, Sebastian-Edgar Baumeister, Henry Völzke, Alexander Welk
To estimate association between the use of interdental cleaning aids (IDAs) and type on 7-year follow-up levels of interdental plaque, interdental gingival inflammation, interdental periodontitis severity, the number of interdental sound surfaces and the number of missing teeth in a population-based cohort study.
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Neutrophil extracellular traps in rheumatoid arthritis and periodontitis: Contribution of PADI4 gene polymorphisms J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-20 Sicília Rezende Oliveira, José Alcides Almeida de Arruda, Ayda Henriques Schneider, Larissa Marques Bemquerer, Rayssa Maria Soalheiro de Souza, Paula Barbim, Gustavo Henrique de Mattos-Pereira, Débora Cerqueira Calderaro, Caio Cavalcante Machado, Sandra Fukada Alves, Paula Rocha Moreira, Renê Donizeti Ribeiro de Oliveira, Paulo Louzada-Júnior, Lucas Guimarães Abreu, Fernando Queiroz Cunha, Tarcília
We sought to investigate the release of neutrophil extracellular traps (NETs) in neutrophils from individuals with rheumatoid arthritis (RA) and controls and compare the presence of NETs in gingival tissues according to periodontal status. Also, the association between single nucleotide polymorphisms (SNPs) of the peptidyl arginine deaminase type 4 (PADI4) gene and the GTG haplotype with RA, periodontitis
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Recombinant bone matrix maintains the graft space, induces vascularized bone regeneration and preserves canine tooth extraction socket structure J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-18 Ai Okamura, Takahiro Hiratsuka, Hideo Fushimi, Ichiro Nishimura
Recombinant bone matrix (RBM) is a newly conceived and engineered porous bone graft granule of average size 600 μm composed of purified recombinant collagen peptide. We sought to examine the behaviour with time of RBM that was grafted in the canine tooth extraction socket.
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CCR2 is a potential therapeutic target in peri-implantitis J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-18 Shasha Yuan, Yiping Wei, Wenting Jiang, Fei Sun, Siqi Li, Qingqing Li, Zhanming Song, Zhongtian Liu, Yaqian Mo, Xuekang Wang, Ning Li, Ping Lv, Shaoping She, Cui Wang, Yu Zhang, Ying Wang, Wenjie Hu
CCR2 (C-C chemokine receptor type 2) plays a crucial role in inflammatory and bone metabolic diseases; however, its role in peri-implantitis remains unclear. This study aimed to explore whether CCR2 contributes to peri-implantitis and the treatment effects of cenicriviroc (CVC) on peri-implant inflammation and bone resorption.
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The transcriptomic response to cannabidiol of Treponema denticola, a phytocannabinoid-resistant periodontal pathogen J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-17 Jinlian Tan, Gwyneth J. Lamont, Michael Sekula, HeeJue Hong, Lucy Sloan, David A. Scott
The use of cannabis, which contains multiple antimicrobials, may be a risk factor for periodontitis. We hypothesized that multiple oral spirochetes would be phytocannabinoid-resistant and that cannabidiol (CBD) would act as an environmental stressor to which Treponema denticola would respond transcriptionally, thereby providing first insights into spirochetal survival strategies.
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A multi-centre randomized controlled trial on alveolar ridge preservation with immediate or delayed implant placement: Need for soft-tissue augmentation J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-12 Jan Cosyn, Lorenz Seyssens, Thomas De Bruyckere, Stefanie De Buyser, Andrej Djurkin, Aryan Eghbali, Jérôme Frédéric Lasserre, Marco Tudts, Faris Younes, Selena Toma
To assess the impact of the timing of implant placement following alveolar ridge preservation (ARP) on the need for soft-tissue augmentation (STA) and to identify the risk factors for horizontal and vertical soft-tissue loss.
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Serum lipoprotein subfractions are associated with the periodontal status: Results from the population-based cohort SHIP-TREND J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-14 Marius Kapp, Birte Holtfreter, Thomas Kocher, Nele Friedrich, Christiane Pink, Henry Völzke, Matthias Nauck
To investigate the medium-term associations of serum protein subfractions derived from proton nuclear magnetic resonance (1H-NMR) spectroscopy with periodontitis and tooth loss.
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Single-cell sequencing identifies inflammation-promoting fibroblast–neutrophil interaction in peri-implantitis J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-13 Jia-ji Mo, Yi-rao Lai, Qian-ru Huang, Yin-ran Li, Yi-jie Zhang, Rui-ying Chen, Shu-jiao Qian
To reveal the cellular composition and molecular environment of the periodontal and peri-implant inflammatory infiltrates through a single-cell sequencing technique, which may explain the pathological difference between these two diseases. A special focus was placed on the phenotypes and potential roles of neutrophils and fibroblasts in peri-implant/periodontal tissue immunity.
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Interdental oral hygiene interventions elicit varying compositional microbiome changes in naturally occurring gingivitis: Secondary data analysis from a clinical trial J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-13 Yong Ge, Shatha Bamashmous, Deborah Mancinelli-Lyle, Mojgan Zadeh, Mansour Mohamadzadeh, Georgios A. Kotsakis
To evaluate the effect of different oral irrigators on the sub-gingival microbiome composition in patients with naturally occurring plaque-induced gingivitis.
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Is transmucosal healing of an implant as effective as submerged healing when simultaneous guided bone regeneration is performed? A preclinical study J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-12 Jin-Young Park, Yoon-Hee Kwon, Young Woo Song, Jae-Kook Cha, Ui-Won Jung, Daniel Thoma, Ronald Jung
To investigate whether transmucosal healing is as effective as submerged healing in terms of buccal bone regeneration when guided bone regeneration (GBR) is performed simultaneously with implant placement.
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Periodontitis stage and grade modifies the benefit of regular supportive periodontal care in terms of need for retreatment and mean cumulative cost J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-12 Muhammad H. A. Saleh, Ann Decker, Andrea Ravidà, Hom-lay Wang, Maurizio Tonetti
This study aimed to characterize the periodontal breakdown during supportive periodontal care (SPC) and to quantify the corresponding cost-effectiveness of periodontal therapy.
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Are periodontitis and dental caries associated? A systematic review with meta-analyses J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-12 Pierluigi Romandini, Crystal Marruganti, William Giuseppe Romandini, Mariano Sanz, Simone Grandini, Mario Romandini
The epidemiological relationship between periodontitis and caries remains controversial, and evidence synthesis is currently lacking. Therefore, this systematic review was designed to answer the following PECO question: ‘In human adults (P), do subjects suffering from periodontitis (E) have higher presence/number of untreated carious lesions and caries experience (O) than subjects not suffering from
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Eligibility and efficacy of a CPC- and CHX-based antiviral mouthwash for the elimination of SARS-CoV-2 from the saliva: A randomized, double-blind, controlled clinical trial J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-12-07 Brunello Giulia, Wolf Viktoria, Kerberger Robert, Bernhard Michael, Lübke Nadine, Becker Jürgen, Schwarz-Herzke Beryl, Timm Jörg, Becker Kathrin
This study aimed at investigating the efficacy of a 0.05% cetylpyridinium chloride–0.05% chlorhexidine (CPC–CHX) mouthwash in reducing viral load in the saliva as compared with sterile water.
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Epidemiology of plaque-induced gingivitis among 12–15-year-old Chinese schoolchildren: A study based on the 2018 case definition J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-11-30 Wenhui Wang, Xiping Feng, Baojun Tai, Deyu Hu, Huancai Lin, Bo Wang, Chunxiao Wang, Shuguo Zheng, Xuenan Liu, Wensheng Rong, Weijian Wang, Yan Si
To explore the epidemiology of plaque-induced gingivitis and related factors among Chinese adolescents.
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The association between trypsin-like protease activity in the oral cavity and kidney function in Japanese workers J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-11-28 Masanori Iwasaki, Maki Inoue, Michihiko Usui, Wataru Ariyoshi, Keisuke Nakashima, Yoshie Nagai-Yoshioka, Tatsuji Nishihara
To evaluate the association between trypsin-like protease (TLP) activity in the oral cavity as an indicator of periodontal health status and kidney function in Japanese workers.
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Clinical and histological wound healing patterns of collagen-based substitutes: An experimental randomized controlled trial in standardized palatal defects in humans J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-11-28 Stefan P. Bienz, Naida Gadzo, Anina N. Zuercher, Daniel Wiedemeier, Ronald E. Jung, Daniel S. Thoma
To evaluate the progression of wound healing of standardized palatal defects in groups using three different collagen-based wound dressings and a control group, in terms of wound closure, pain perception and descriptive histology.
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Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral–gut and gut–oral axes through bidirectional Mendelian randomization J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-11-28 Hang Chen, Limin Peng, Zhenxiang Wang, Yujuan He, Xiaonan Zhang
This Mendelian randomization (MR) study was performed to explore the potential bidirectional causal relationship between the gut microbiome (GM) and periodontitis.
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Periodontitis and the risk of all-cause and cause-specific mortality among US adults with diabetes: A population-based cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2023-11-15 Weiqi Li, Jiakuan Peng, Qianhui Shang, Dan Yang, Hang Zhao, Hao Xu
To evaluate the association between periodontitis, all-cause and cause-specific mortality, and its prognostic utility among adults with diabetes.