BackgroundThe diagnostic performance of active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care oral rinse test (POC‐ORT) for periodontitis needs to be improved because of its relatively low sensitivity. This study attempted to identify the clinical features associated with the misclassification of periodontal cases by the test.MethodThis work consisted of two cross‐sectional diagnostic accuracy studies

BackgroundAesthetics and patient‐reported experiences (PREs) and outcomes (PROs) influence treatment choices, but have been largely overlooked in periodontology and implant dentistry. This consensus conference evaluated these factors by focusing on gingival recession defects (GRDs), immediate or early/delayed implant placement and peri‐implant buccal soft‐tissue dehiscences.MethodsThe workshop discussions

AimThe evidence for tooth splinting during periodontal regenerative therapy is limited. We aimed to investigate the adjunctive benefits of tooth splinting on clinical outcomes.Materials and MethodsIn total, 194 intrabony defects in 126 participants were prospectively evaluated over three years following periodontal regenerative therapy with an enamel matrix derivative. Clinical attachment level (CAL)

AimTo evaluate the determinants of early implant failure after sinus augmentation (SA).Materials and MethodsWe conducted a nested case–control study of implants placed after SA between 2016 and 2021 in eight centres across Germany. We included a total of 129 implants that were lost within 12 months after placement (cases) and 273 implants that were not lost within 12 months (controls). Multivariable

AimTo leverage technological advances to propose a more accurate representation of subgingival microbiota diversity and dynamics across health and disease, 25 years after the seminal and still authoritative contribution of Socransky and his colleagues.Materials and MethodsSubgingival plaque from 135 patients (41 healthy, 47 gingivitis, 47 periodontitis) was analysed by V3–V4 16S rRNA sequencing. Sequences

AimTo assess the feasibility of applying sequential, multiple assignment, randomized trial (SMART) design in periodontology and to assess the response of grade III furcation‐involved molars to various treatments.MethodsA member of the public served as a co‐investigator. Twenty participants with at least one grade III furcation‐involved molar tooth were randomized to either non‐surgical periodontal

AimThis observational study aimed to verify and improve the predictive value of plaque microbiome of patients with dental implant for peri‐implant diseases.Materials and MethodsPatients were included in one of the following study groups according to the health status of their dental implants: (a) healthy, (b) affected by mucositis and (c) affected by peri‐implantitis. From each patient, submucosal

ObjectiveTo evaluate the survival of teeth with class II furcation involvement (FI) ≥ 5 years after active periodontal treatment (APT) and to identify the prognostic factors.MethodsAll charts of patients having undergone APT at the Department of Periodontology of Goethe‐University Frankfurt, Germany, were screened for teeth with class II FI. APT had to be accomplished ≥ 5 years ago. Charts were analysed

AimTo evaluate the efficacy of the apically positioned flap (APF) with periosteal fenestration in increasing the width of the masticatory mucosa (MM, including attached and keratinized mucosa) and to assess the histological properties of the MM gained through this technique.Materials and MethodsSix mongrel dogs were treated using a split‐mouth design, with APF alone (control) and APF with periosteal

AimThis secondary analysis of a randomised clinical trial aimed to investigate vertical ridge augmentation (VRA) by comparing complication rates (primary outcome), times, costs and patient‐reported outcome measures (PROMs) between customised Ti‐reinforced PTFE mesh and customised CAD/CAM titanium mesh.Materials and MethodsPatients with vertical bone defects were randomly assigned to alveolar bone augmentation

AimTo examine the accuracy of microbiological biomarkers in diagnosing periodontal diseases, specifically addressing three focus questions: (FQ1) distinguishing health from disease; (FQ2) predicting disease progression; and (FQ3) assessing treatment outcomes.Materials and MethodsA PRISMA‐guided search in MEDLINE, EMBAS and WEB OF SCIENCE included cross‐sectional and longitudinal studies (e.g., randomised

AimTo assess the clinical response to Non‐Surgical Periodontal Therapy (NSPT) between suprabony and intrabony defects.Materials and MethodsTotally 200 NSPT patients' records from the King's College London—Oral, Dental and Craniofacial Biobank were included. Periapical radiographs of sites with Periodontal Probing Depth (PPD) > 4 mm were assessed. Changes in periodontal measurements between baseline

AimTo investigate the influence and mechanism of exosomes derived from human gingival mesenchymal stem cells (GMSC‐Exo) regulating macrophage polarisation through metabolic reprogramming.Materials and MethodsHuman acute monocytic leukaemia cells (THP‐1)‐derived macrophages were treated with GMSC‐Exo or Porphyromonas gingivalis lipopolysaccharide (P.g‐LPS) in vitro. Metabolic inhibitors were used to

AimThis study aimed to evaluate the efficacy of the modified minimally invasive surgical technique (M‐MIST) combined with a collagen‐enriched bovine‐derived xenograft (CEBDX) for the treatment of isolated interdental intrabony defects.Materials and MethodsThis is a randomized controlled trial including 40 isolated interdental intrabony defects in 40 patients. The test group received M‐MIST and CEBDX

AimThere is evidence linking tooth loss with dementia; however, similar findings for periodontitis are inconclusive.Material and MethodsWe conducted cross‐sectional (N = 4046) and longitudinal analyses (N = 2769) on data from the Health 2000 and 2011 surveys for establishing any associations of periodontal health with baseline cognition, 11‐year risk of cognitive decline and 15‐year risk of incident

AimsTo investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase‐9 (MMP‐9) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis.Materials and MethodsThis prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34)

AimTo evaluate the effect of prolonged fasting on the oral microbiome in patients with metabolic syndrome (MetS).Materials and MethodsThis follow‐up study evaluated changes in the oral microbiome in a sub‐cohort of 42 patients with MetS during prolonged fasting. Periodontal parameters such as bleeding on probing (BOP), plaque index (PI) and gingival crevicular fluid (GCF) measured in Periotron units

AimTo investigate the associations between periodontal inflammation—as determined by the periodontal inflamed surface area (PISA)—and serum inflammatory markers in community‐dwelling older adults in Japan.Materials and MethodsThis cross‐sectional study included 470 adults (mean age: 73.1 years). The composite inflammatory marker z‐score (CIMZ) was calculated as the sum of the participants' individual

ObjectiveThis systematic review aimed to answer the question: In patients undergoing periodontal and peri‐implant surgery, gingival augmentation, implant site development or placement, are pre‐emptive analgesics effective in controlling post‐operative pain compared with patients not receiving pre‐emptive medications?Materials and MethodsAfter comprehensive electronic and manual literature searches

AimTo evaluate the performance and implementation of the 2018 Classification of Periodontal Diseases for periodontitis through systematic review and survey methodology.Materials and MethodsA two‐part systematic review was conducted. Part 1 aimed, with descriptive statistics, to evaluate performance metrics of the 2018 Classification, including diagnostic accuracy, prognostic performance and examiner

AimTo estimate alcohol consumption's effect on edentulism using state alcohol taxes as an instrumental variable (IV).Material and MethodsAnalysis of 514,357 U.S. Behavioural Risk Factor Surveillance System participants (2003–2006, 2008, 2010, 2012) linked to state alcohol taxes. We used IV regression modelling to assess the relationship between alcohol consumption and edentulism, plus potential mediators

BackgroundThis Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impetus for the workshop, including the limited quality of available research on diagnostic tests, the rapid development of new technologies, the implementation of the

AimTo determine whether clinical parameters can serve as (i) predictive tools (before occurrence) and (ii) diagnostic tools (after occurrence) of peri‐implant bone loss.Materials and MethodsA representative cohort of 72 patients with 298 implants was evaluated at baseline and after a mean follow‐up period of 3.9 years. Peri‐implant bone loss > 1 mm between the two examinations represented the reference

AimTo compare a dense polytetrafluoroethylene (dPTFE) membrane with a collagen membrane in guided bone regeneration for lateral bone augmentation at single sites in the anterior maxilla in terms of alveolar width, height, complications, need for additional therapy and implant outcomes.Materials and MethodsPatients with a class 4 defect at a single site in the anterior maxilla (15–25) were recruited

AimThis randomised controlled trial (RCT) with a 3‐year follow‐up was aimed at assessing the clinical and radiographic outcomes of implants with either a hybrid or moderately rough macro‐surface design placed in patients with a history of periodontitis.Material and MethodsForty periodontitis subjects with a stable periodontal condition were included and randomly assigned to receive either a hybrid

AimTo assess the adjunctive effect of periodontal therapy on psoriasis‐related outcomes in a combined experimental model of ligature‐induced periodontitis and Imiquimod (IMQ)‐induced psoriasis. Also, this experiment aimed to study the impact of TNF‐α inhibitors on the periodontium.MethodsFifty‐six C57/BL6J mice were randomly allocated to seven experimental groups: (a) control group (P–Pso–) with no

ObjectiveTo identify host markers with optimal diagnostic performance for clinical implementation in the diagnosis of periodontal diseases and prediction of future disease progression and/or disease resolution.Material and MethodsCross‐sectional and prospective studies with ≥ 20 participants per group, reporting diagnostic accuracy (e.g., area under the curve [AUC]) of host markers for periodontal

Background and AimManaging periodontal disease often involves complex decisions involving multiple treatment options, and patient autonomy significantly influences this decision‐making process. This study aimed to characterise the autonomy and information‐seeking preferences among patients diagnosed with stage III/IV periodontitis, and to identify the factors influencing these preferences.Materials

AimTo evaluate the impact of macrophage depletion on bone loss and inflammatory responses in a mouse model of peri‐implantitis, assessing macrophage depletion potential as a therapeutic strategy.Materials and MethodsUsing 6‐week‐old male C57BL/6 mice, peri‐implantitis was induced by placing a silk ligature around osteointegrated dental implants. Mice were divided into three groups: Healthy control

AimTo evaluate early buccal bone resorption (BBR) in areas with or without buccal keratinized tissue (KT), and different mucosal thickness (MT) following implant placement at healed sites.Materials and MethodsIn 9 beagle dogs, three months following the hemimaxilla third and fourth premolars extraction, full‐thickness flaps were elevated and two tissue‐level implants were inserted. Before suturing

AimsTo quantify changes in soft‐tissue volume induced by non‐surgical periodontal therapy (NSPT) in patients with periodontitis and correlate them with clinical parameters and smoking. A new digital approach is investigated because standard periodontal clinical assessment methods are unable to accurately capture volumetric changes.Materials and MethodsThirty‐nine subjects with periodontitis aged 27–70

AimTo assess the efficacy of injectable bone fillers for alveolar ridge preservation (ARP).Materials and MethodsThe mandibular premolars (P2, P3, P4) were bilaterally assigned to ARP in a total of n = 9 beagle dogs. Each P was decapitated and hemisected under preservation of the mesial (i.e., devitalization and filling with calcium hydroxide) and removal of the distal root. The resulting 6 extraction

AimTo evaluate a deep learning (DL) model for detecting keratinized gingiva (KG) in dental photographs and validate its clinical applicability using reference retainers for calibration.Materials and MethodsA total of 576 sextant photographs were selected from 32 subjects, each with three sets of photographs: iodine‐stained, unstained and line‐marked retainers. Relative keratinized gingiva width (rKGW)

AimsTo identify genetic biomarkers that may be used in the diagnosis, prevention or management of different forms of periodontal disease.Materials and MethodsFollowing protocol registration and PICOTS (patient, intervention, comparison, outcome, time, studies) questions, a systematic search of the literature was conducted (PudMed, Ovid), resulting in 1592 papers screened by two reviewers. Diagnostic

AimsTo evaluate the impact of an anti‐sensitivity toothpaste on the oral‐health‐related quality of life (OHrQoL) in a real‐world (RW) setting.Materials and MethodsThis was a decentralised, prospective, 24‐week, open‐label study in participants with self‐reported dentine hypersensitivity (DH). A total of 655 enrolled participants used a 5% potassium nitrate toothpaste per label instructions and completed

The cover image is based on the article Impact of Collagen Membrane in Vertical Ridge Augmentation Using Ti‐Reinforced PTFE Mesh: A Randomised Controlled Trial by Istvan A. Urban et al., https://doi.org/10.1111/jcpe.14129. image

AimTo evaluate the clinical, microbial and cytokine changes following the use of oral azithromycin as an adjunct to non‐surgical subgingival instrumentation (NSI) in stage III/IV, grade C periodontitis through a triple‐blind, parallel‐armed, randomised controlled trial.Material and MethodsA total of 52 patients with stage III/IV grade C periodontitis were randomly allocated to two groups receiving

AimTo comprehensively review digital technologies (including artificial intelligence, AI) for periodontal screening, diagnosis and prognosis in the dental setting, focusing on accuracy metrics.Materials and MethodsTwo separate literature searches were conducted for periodontal screening and diagnosis (part I, scoping review) and prognosis (part II, systematic approach). PubMed, Scopus and Embase databases

AimThis systematic review aimed to answer the following PECOS questions: In human subjects with untreated periodontitis (Q1) or enrolled in supportive periodontal care (SPC) (Q2) (P), are there clinical assessment methods (E) other than the contemporary manual probe (C) that increase diagnostic accuracy or reliability when examining/screening for periodontitis (Q1) or when monitoring disease stability

Sub‐gingival non‐surgical periodontal therapy (NSPT) constitutes step 2 of periodontal therapy, aiming to disrupt the subgingival microbial biofilm and resolve or reduce inflammation of the supracrestal periodontal tissues. A plethora of original studies and reviews have been published over several decades, highlighting its fundamental importance in periodontal therapy and in tooth survival. Evidence

AimTo investigate the association of alcohol consumption with periodontitis risk and change in periodontal parameters over time.MethodsUsing data from 1285 participants of two population cohort studies embedded in the Study of Health in Pomerania, we associated baseline average alcohol consumption with incident periodontitis measured after a median follow‐up time of 5.0 years, adjusting for confounding

AimTo assess the efficacy of citric acid passivation on implant abutments by evaluating their impact on bacterial load, microbiome composition, inflammatory response, and clinical and radiographic outcomes compared with control abutments over a 12‐month follow‐up period.MethodsImplants were placed subcrestally in the posterior sextants and randomly assigned to receive a 2‐mm high definitive abutment

AimTo evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time‐restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.Material and MethodsAll participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1–T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular

AimThis study aims to investigate the early alterations in microbiome construction and succession around dental implants in both periodontally healthy individuals and patients with a history of periodontitis during the first month after implant–crown placement.Materials and MethodsNinety‐five subgingival plaque samples were collected from 10 periodontally compromised patients (PCP) and nine periodontally

AimsTo externally validate the potential applicability of the 2018 classification of periodontal diseases as a risk assessment tool, through the use of a nomogram built on a multivariate predictor model.Materials and MethodsData from 459 patients with periodontitis, across four cohorts (three in the United States, and one in the United Kingdom), were retrospectively analysed. After staging and grading

AimTo investigate the effects of hyperuricemia on periodontitis and the underlying mechanisms by establishing combined animal and cell models.MethodsA hyperuricemia mouse model was established by potassium oxonate injection, with sodium carboxymethylcellulose treatment serving as controls. Both models were treated with or without periodontitis induction (n = 10/group). RAW264.7 macrophages and THP‐1‐derived

AimTo assess the reliability of ultrasonographic, cone beam computed tomographic (CBCT), probe transparency and transgingival probing (TGP) methods in evaluating gingival thickness (GT), compared with the gold standard histological assessment.MethodsSixteen fresh cadaver heads with intact gingivae were used. The sequence for GT measurement included CBCT, ultrasonography, probe transparency, TGP and