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Hyperacute Outer Retinal Dysfunction JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-13 Yizhe Cheng, Xinyu Liu, Jinglin Lu, Jianing Ren, Ping Fei, Meini Chen, Changting Tang, Jianping Zhang, Minglian Zhang, Miner Yuan, Limei Sun, Linyan Zhang, Aohan Hou, Yili Jin, Yanting Lai, Qiong Wang, Wenjia Yan, Shuya Ke, Xiaoxin Li, Xiaoyan Ding
ImportancePattern recognition of pediatric retinal diseases can streamline the workup and guide the prognosis.ObjectiveTo characterize the clinical features, retinal imaging findings, and 1-year prognosis of pediatric patients who experienced sudden, severe bilateral vision loss with diffuse ellipsoid zone (EZ) and external limiting membrane (ELM) disruptions after fever.Design, Setting, and ParticipantsThis
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Federally Qualified Health Centers as a Model to Improve Vision Health: A Systematic Review. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-13 Patricia Bai,Spencer S Burt,Maria A Woodward,Scott Haber,Paula Anne Newman-Casey,Jeffrey D Henderer,R V Paul Chan,Aiyin Chen,
Importance Disparities in eye health are associated with lower-income and minoritized populations, many of whom seek care at federally qualified health centers (FQHCs). Objective To examine the literature addressing vision and eye health care provided at FQHCs, identify barriers to providing care at FQHCs, and highlight recommendations on how FQHCs can decrease disparities in eye health. Evidence Review
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Hyperacute Outer Retinal Dysfunction-A Retina on Fire. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-13 Timothy M Boyce,Ian C Han
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Generative Artificial Intelligence Guidelines of Ophthalmology Journals. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-13 David E Rabinovitch,Jim S Xie,Adrien Lusterio,Andrew Mihalache,Marko M Popovic,Prashant D Tailor,Brendan Tao,Edward Margolin
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Expanding Vision Services at Federally Qualified Health Centers. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-13 Sally S Ong
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Realistic fundus photograph generation for improving automated disease classification. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-12 Prashant U Pandey,Jonathan A Micieli,Stephan Ong Tone,Kenneth T Eng,Peter J Kertes,Jovi C Y Wong
AIMS This study aims to investigate whether denoising diffusion probabilistic models (DDPMs) could generate realistic retinal images, and if they could be used to improve the performance of a deep convolutional neural network (CNN) ensemble for multiple retinal disease classification, which was previously shown to outperform human experts. METHODS We trained DDPMs to generate retinal fundus images
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Incidence, sociodemographic and presenting clinical features of childhood non-infectious uveitis: findings from the UK national inception cohort study. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-11 Ameenat Lola Solebo,Salomey Kellett,Eibhlin McLoone,Harry Petrushkin,Jose Gonzalez-Martin,Jane Ashworth,Jessy Choi,Rachel F Pilling,Kate Armon,Kishore Warrier,Srilakshmi M Sharma,Jugnoo S Rahi,,
BACKGROUND We aimed to provide, through the Uveitis in Childhood National Cohort Study, population-based evidence on incidence, distribution and disease characteristics for childhood onset non-infectious uveitis. METHODS Eligible children and young people (<18 years) were those newly diagnosed with non-infectious uveitis between 1 March 2020 and 28 February 2023. Cases were identified and recruited
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The Safety of Office-Based Pterygium Surgery. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-10 Sandra Lora Cremers,Adam Hidad,Jenny Ha,Matthew Joy,Kishan Avaiya,Emma Antall,Elise Bolin,J Alberto Martinez
PURPOSE Hospital and ambulatory eye surgical procedures continue to transition to the office setting. Pterygium surgery is the most commonly performed ocular surface surgical procedure in the world. No studies to date have evaluated its safety in the office-based surgical setting. Our study evaluates the safety, complication rate, cost-savings, and cosmetic satisfaction of office-based pterygiectomy
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Associations between a healthy lifestyle score and retinal neurovascular health. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-10 Xiaomin Zeng,Ruiye Chen,Xiayin Zhang,Ting Su,Yaxin Wang,Yijun Hu,Xianwen Shang,Danli Shi,Honghua Yu
AIMS To investigate the associations between a healthy lifestyle score and retinal neurovascular health, and explore whether lower inflammation levels mediate these associations. METHODS This study is based on the UK Biobank. The healthy lifestyle score ranged from 0 to 6 and comprised physical activity, diet, sleep duration, smoking status, alcohol consumption and bodyweight. Outcomes included retinal
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Comparative Cost Analysis of Secondary Intraocular Lens Surgeries Using Time-Driven Activity-Based Costing. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-08 Warren W Pan,Crystal Young,David Portney,Amanda Fowler,Shahzad I Mian,Emily Eton,Thomas J Wubben
OBJECTIVE To assess the economics of secondary IOL surgeries, with a focus on variations in day-of-surgery costs based on surgical approach and number of surgeons involved. DESIGN Retrospective, time-driven, activity-based costing study analyzing costs and reimbursement rates. SETTING University of Michigan Kellogg Eye Center, analyzing procedures performed between January 1, 2014 and December 31,
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Epidemiology of Cataract-related Blindness in Brazil: 30 Years of Public Policy Evolution: Review Article. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-08 Newton Kara-Junior,Silvana Rossi
PURPOSE This review evaluated the impact of various public policies on the number of cataract surgeries performed annually by the Public Health System (SUS) in Brazil and its regions. The goal was to provide insights for managers and the medical community to assess the effectiveness of strategies to prevent cataract-related blindness. DESIGN Trend studies based on literature review. METHODS This study
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Autograft Donor Site Repair In Pterygium Surgery. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-07 Minas T Coroneo,Ximena Masgoret,Vijay Reena Durai
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Five to Twelve Year Outcomes of Autologous Simple Limbal Epithelial Transplantation. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-07 Swapna S Shanbhag,Anahita Kate,Shayeri Ganguly,Saumya Jakati,Rashmi Deshmukh,Sayan Basu
PURPOSE To objectively assess the long-term corneal epithelial recovery after autologous simple limbal epithelial transplantation (SLET) for ocular chemical burn (OCB)-induced unilateral limbal stem cell deficiency (LSCD). DESIGN Prospective, fellow-eye controlled, cross-sectional imaging and diagnostic study. SUBJECTS The study included 47 patients, who were 5 to 12 years post-autologous SLET done
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Titaminates, A Biocompatible Titanium-Organic Hybrid Film, Support the Growth and Function of Conjunctival Epithelial Cells. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-07 Changrim Lee,Veronica Anne-Line Kathrine Killi,Ola Nilsen,Darlene A Dartt
OBJECTIVE OR PURPOSE To find an ideal biosurface to regenerate conjunctival epithelium. DESIGN Experimental Study SUBJECTS AND CONTROLS: Human primary conjunctival epithelial cells expanded ex vivo from human cadaveric tissues and total of eight biosurfaces. Eight biosurfaces include one negative control (unmodified glass coverslip) and seven bioengineered metal-organic hybrid films fabricated using
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Geographical Distribution of Ophthalmologists in the United States by Gender. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-07 Maya T Harrington,Sophie J Bakri
PURPOSE Female representation is growing each year in ophthalmology, but women are still underrepresented overall. Due to the potential impact of physician gender on the physician-patient relationship, this imbalance could affect patient outcomes and satisfaction. This study describes the geographic variation of gender disparities in ophthalmology throughout the United States. DESIGN Retrospective
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Can Medicare Data Describe COVID-19 Practice Pattern Changes? JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-06 Sean T Berkowitz,Avni P Finn
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Importance of Thickness When Evaluating Choroidal Tumors. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-06 Carol L Shields
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Pixel Intensity to Estimate Choroidal Tumor Thickness Using 2-Dimensional Ultra-Widefield Images JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-06 Michael D. Yu, Michael Heiferman, Edward Korot, Aneesha Ahluwalia, Gina Yu, Prithvi Mruthyunjaya
ImportanceTumor thickness is a well-established risk factor for malignant transformation of choroidal nevus into melanoma. To date, reliable evaluation of tumor thickness relies on B-scan ultrasonography, which is frequently unavailable at nonsubspecialty clinics where most melanocytic choroidal lesions (MCLs) are first diagnosed.ObjectiveTo describe a technique for potential rapid and reliable estimation
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COVID-19 Pandemic and Rates of Common Ophthalmic Procedures Among Medicare Beneficiaries JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-06 Raziyeh Mahmoudzadeh, Mariam Samuel, Sydney Wheeler, Mirataollah Salabati, Christopher T. Leffler, Jessica D. Randolph
ImportanceThe COVID-19 pandemic has altered health care delivery, including ophthalmic care. Understanding how the pandemic has changed the rates of commonly performed ophthalmic procedures is crucial for assessing the broader implications for patient care and resource allocation.ObjectiveTo estimate the changes in the rates of the 10 most prevalent ophthalmic procedures among Medicare beneficiaries
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Primary Conjunctival Rhabdomyosarcoma Presenting as an Enlarging Papillomatous Lesion in a 3-Year-Old JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-02-06 Zara Saleem, Alan D. Proia, Lars M. Wagner, Olivia J. Killeen, Sharon F. Freedman
This case report describes a rapidly growing conjunctival lesion in a 3-year-old patient, which was incompletely resected and diagnosed as rhabdomyosarcoma.
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Relationship between chemokine in aqueous humor and primary glaucoma: A meta-analysis. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-06 Xin Sun,Jing Zhou,Xiandong Zeng,Yanhua Jiang
OBJECTIVE Glaucoma is a group of diseases characterized by optic nerve damage and corresponding visual field loss as clinical changes. A close relationship has been identified between chemokine in aqueous humor and primary glaucoma; however, this association remains controversial. DESIGN Systematic review and meta-analysis METHODS: The Web of Science, Wiley Online Library, PubMed, and Embase databases
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Which test is best: evaluation of traditional and contemporary statistical tests for analysis of spherical equivalent prediction error. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-06 Nathan T Cannon,Giacomo Savini,Seth M Pantanelli,Kenneth Hoffer,Petros Aristodemou,Kamran Riaz,David Murphy,David Griffin,Christian Berry,Guillaume Debellemanière,Mathieu Gauvin,Avi Wallerstein,Woong-Joo Whang,Kyungmin Koh,Kazuno Negishi,Ken Hayashi,Diogo Hipólito-Fernandes,David L Cooke
PURPOSE To characterize the performance of traditional and contemporary statistics tests for analysis of spherical equivalent prediction error (SEQ-PE) after cataract surgery, with regard to test significance and self-consistency. DESIGN Comparison of the utility of statistical tests. SUBJECTS Eyes from 5 academic centers and 2 private practices that had cataract surgery and postoperative manifest
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Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-02-05 Min Hee Suh,Robert N Weinreb,Evan Walker,Linda M Zangwill
PURPOSE To investigate the relationship between optic disc vessel density (ODVD) reduction and visual field (VF) progression in primary open-angle glaucoma (POAG) patients. DESIGN Retrospective case series. METHODS A total of 187 POAG eyes underwent ≥ 5 consecutive VF, spectral-domain optical coherence tomography, and swept-source OCT angiography imaging sessions during ≥ 3 years of follow-up. ODVD
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High-sensitivity C-reactive protein and risk of retinal artery occlusion and ischaemic stroke: a cross-cohort study. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-04 Yaxin Wang,Xiayin Zhang,Anyi Liang,Yong Yi Niu,Daiyu Chen,Zijing Du,Wei Wu,Feng Zhang,Guanrong Wu,Ying Fang,Xianwen Shang,Zhuoting Zhu,Yijun Hu,Lidan Hu,Honghua Yu,Xiangjun Chen
AIMS Previous studies have suggested an association between retinal artery occlusion (RAO) and ischaemic stroke (IS), both associated with elevated inflammatory factors. However, the role of high-sensitivity C-reactive protein (hs-CRP) in the sequential onset of these two diseases is still unclear. Based on this evidence, we evaluated the association of hs-CRP with RAO and IS. METHODS We examined hs-CRP
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Associations between serum lipids and glaucoma: a cohort study of 400 229 UK Biobank participants. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-04 Yiyuan Ma,Yue Wu,Leyi Hu,Wen Chen,Xinyu Zhang,Danying Zheng,Nathan Congdon,Guangming Jin,Zhenzhen Liu
PURPOSE To examine the associations of commonly-used serum lipid measures (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triglycerides (TG)) with glaucoma. METHODS This prospective cohort study included 400 229 participants from the UK Biobank. Cox regression and restricted cubic spline models and polygenic risk scores were employed
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Evaluating lipid-lowering drug targets for full-course diabetic retinopathy. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-03 Jiahui Cao,Ting Su,Shuilian Chen,Zijing Du,Chunran Lai,Kaiyi Chi,Qinyi Li,Shan Wang,Qiaowei Wu,Yunyan Hu,Ying Fang,Yijun Hu,Zhuoting Zhu,Yu Huang,Xiayin Zhang,Honghua Yu
BACKGROUND Implementing lipid control in patients with diabetes is regarded as a potential strategy for halting the advancement of diabetic retinopathy (DR). This study seeks to use Mendelian randomisation (MR) to assess the causal relationship between lipid traits and lipid-lowering drug targets and full-course DR (background DR, severe non-proliferative DR (NPDR) and proliferative DR (PDR)). METHODS
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Comparative insights into the role of sex hormones in glaucoma among women and men Prog. Retin. Eye. Res. (IF 18.6) Pub Date : 2025-01-31 Sharon H. Zhao, Christine K. Kim, Tala Al-Khaled, Margaret Ann Chervinko, Anne Wishna, Rukhsana G. Mirza, Thasarat Sutabutr Vajaranant
Baseline differences in sex hormone levels between males and females influence tissues including the brain and eye. To investigate the effects of estrogens and androgens on ocular physiology and glaucoma, we review the current literature on the influence of primary sex hormones on ocular function, glaucoma incidence and related parameters like intraocular pressure (IOP) at physiologic levels and related
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Effect of hematopoietic stem cell transplantation on meibomian gland structure Ocul. Surf. (IF 5.9) Pub Date : 2025-01-31 Andrea Novo-Diez, Jens Horstmann, Itziar Fernández, Margarita Calonge, María J. González-García, Philipp Steven
To assess morphological changes in the meibomian glands (MGs) pre- and post-hematopoietic stem cell transplantation (HSCT).
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Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1 Ocul. Surf. (IF 5.9) Pub Date : 2025-01-31 Yong Yuan, Shingo Yasuda, Kaitlyn L. Funk, Winston Kao, Shizuya Saika, Adam Kaufman, Chia-Yang Liu
To understand how Tbr1 and Smad4 play a pivotal role in controlling ECM synthesis versus degradation for maintaining corneal stromal homeostasis and otherwise leading to corneal ectasia.
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The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study Ocul. Surf. (IF 5.9) Pub Date : 2025-01-31 Fiona Stapleton, Tianni Jia, Venita DePuy, Charles Bosworth, Marc Gleeson, Jacqueline Tan
To explore effects of topical 1 % selenium sulfide on signs and symptoms in symptomatic contact lens-wearers, in an exploratory 4-month prospective placebo-controlled double-masked randomised trial.
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Strabismus Surgery in Patients Aged Over 80 Years: Indications, Safety, and Outcomes. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-01-31 Veronika Yehezkeli,Stacy L Pineles,Joseph L Demer,Qingyu Meng,Federico G Velez
OBJECTIVE Strabismus in the elderly can cause functional and psychological difficulties, particularly due to the impact of diplopia. Surgical intervention may alleviate diplopia and diminish psychosocial impact. However, the complexity of strabismus types, along with related ocular conditions and general health issues, pose unique challenges. This study explores the indications, safety, and outcomes
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Relationship Between Chronic Stress Measured by Allostatic Load and Age-Related Macular Degeneration in the All of Us Research Program. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-01-31 Kristy Yoo,Linda Wu,Brian Toy,Benjamin Y Xu
PURPOSE To assess the longitudinal relationship between age-related macular degeneration (AMD) and allostatic load (AL), an established framework for quantifying the physiologic effects of chronic stress through measurements of systemic biomarkers. DESIGN Retrospective case-control study. METHODS Participants of the National Institutes of Health All of Us (AoU) Research Program with complete AL biomarker
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Risk factors for rapid axial length growth in a prospective cohort study of 3-year to 9-year-old Chinese children. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-31 Yanze Yu,Hao Chen,Zhe Zhang,Yuhao Ye,Yang Shen,Ye Xu,Ke Zheng,Xiaoying Wang,Yingnan Jia,Xingtao Zhou,Jing Zhao
AIMS To identify factors contributing to rapid axial length (AL) growth in children aged 3-9 years. METHODS Four thousand four hundred thirty-five children were followed from 2019 to 2022. AL and corneal curvature were measured using an IOLMaster 500, while refractometry and visual acuity were also assessed. Baseline data included demographics and parental myopia status, with annual updates on height
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GLP-1 RAs and Nonarteritic Anterior Ischemic Optic Neuropathy-Making Sense of the Data. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-01-30 Mahyar Etminan,Mohit Sodhi,David Maberley
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Adverse Events in a Mobile Eye Health Outreach Program JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-01-30 Ryan Schmidt, Dove Spector, Verian Wedeking, Annette M. Totten, Mitchell V. Brinks
This survey study describes the postprocedure conditions experienced by individuals who received eye screening from the mobile Casey Outreach Program clinics in Oregon.
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Ophthalmic Complications Associated With the Antidiabetic Drugs Semaglutide and Tirzepatide JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-01-30 Bradley J. Katz, Michael S. Lee, Norah S. Lincoff, Anne S. Abel, Somya Chowdhary, Brian D. Ellis, Ahmad Najafi, John Nguyen, Meagan D. Seay, Judith E. A. Warner
ImportanceNearly 2% of the US population received a prescription for semaglutide in 2023. There has been a recent concern that this drug and other similar medications may be associated with ophthalmic complications.ObjectiveTo report ophthalmic complications associated with the use of semaglutide or tirzepatide.Design, Setting, and ParticipantsThis was a retrospective case series. All patients were
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The Global Epidemiology of Scleritis: A Systematic Review and Meta-analysis. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-01-30 Carlos Cifuentes-González,Germán Mejía-Salgado,William Rojas-Carabali,Josué Tovar-Tirado,Luis Alejandro Diez-Bahamón,María Andrea Bernal-Valencia,Paula Tatiana Muñoz-Vargas,Danna Lesley Cruz-Reyes,Carlos E Pavesio,Peter McCluskey,James T Rosenbaum,Rupesh Agrawal,Alejandra de-la-Torre
PURPOSE Scleritis, a severe inflammatory condition of the sclera, causes significant ocular pain and potential tissue damage. Often linked with systemic diseases, scleritis can be either infectious or noninfectious. Despite its clinical importance, the global incidence and detailed epidemiology of scleritis are poorly understood due to its heterogeneity and rarity. This systematic review and meta-analysis
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Characteristics of Patients with Late-onset Intraocular Lens Dislocation: A Prospective Multicenter Clinical Cohort Study in Japan: Real-world data of late-onset IOL dislocation in Japan. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-01-30 Ken Hayashi,Tatsuhiko Sato,Norihito Gotoh,Kazutaka Kamiya,Takashi Kojima,Masaki Sato,Hitoshi Tabuchi,Natsuko Hatsusaka,Yoshihiro Tokuda,
PURPOSE To evaluate the patients' characteristics and ocular features of those who underwent surgery for late-onset intraocular lens (IOL) dislocation from 2020 to 2021 at multiple surgical centers in Japan. We also assessed the factors influencing the duration between prior IOL implantation and IOL dislocation repair as well as the factors affecting visual prognosis after IOL dislocation repair surgery
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Laser speckle flowgraphy reveals widespread reductions in ocular blood flow in non-exudative age-related macular degeneration. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-01-30 Edward F Linton,Noor-Us-Sabah Ahmad,Riley Filister,Jui-Kai Wang,Elliott H Sohn,Randy Kardon
OBJECTIVE To evaluate whether and where laser speckle flowgraphy (LSFG)-derived indices of ocular blood flow are reduced in non-exudative age-related macular degeneration (AMD) compared with age-matched control subjects. DESIGN Retrospective case-control study PARTICIPANTS: 39 eyes of 24 subjects with AMD and 41 eyes of 21 healthy controls were included. METHODS Subjects with non-exudative AMD in the
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Registry-based randomised controlled trials in glaucoma: the time is right? Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-30 Mitchell Lawlor,Catherine Q Sun,Gus Gazzard
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Burden of blindness and visual impairment associated with corneal opacities in India. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-30 Vivek Gupta,Praveen Vashist,Sukumara Sarath,Noopur Gupta,Suraj Singh Senjam,Palllavi Shukla,Bindiganavale Ramaswamy Shamanna,Vemparala Rajshekhar,Meenakshi Wadhwani,Amit Bhardwaj,Promila Gupta,Jeewan S Titiyal
PURPOSE To obtain national-level data on current burden of blindness and visual impairment (VI) due to corneal opacities (CO) and their epidemiological determinants in India. METHODS A cross-sectional, population-based survey was conducted in 31 districts for population aged ≥50 years using Rapid Assessment of Avoidable Blindness (RAAB) V.6 methodology and 6 districts for population aged 0-49 years
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Risk factors for visual loss after excision of orbital cavernous venous malformations: a systematic review. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-30 James Pietris,Clare Quigley,Alkis James Psaltis,Geoffrey E Rose,Dinesh Selva
BACKGROUND Orbital cavernous venous malformations (OCVMs) are the most common primary orbital mass lesion and presenting symptoms are usually secondary to a mass effect. Surgical excision presents unique challenges and vision loss is a rare, but devastating, complication. This review aims to identify risk factors for vision loss with excision of OCVMs. METHOD A systematic search of the databases PubMed/MEDLINE
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The influence of anterior chamber depth on the calculation of piggyback intraocular lenses. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-01-29 Dante Buonsanti,Kenneth J Hoffer,Catarina P Coutinho,Giacomo Savini
OBJECTIVE Demonstrate the variability of the spherical and toric ratios between the refraction at the intraocular lens (IOL) plane and the refraction at the spectacle plane when the sphere and the cylinder power of toric piggyback IOLs are calculated. Also, a comparison of the results of piggyback power calculation with variable ratios, to the power calculation performed by a major manufacturer online
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Neuropathic corneal pain following refractive surgery: risk factors, clinical manifestations, imaging and proteomic characteristics. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-29 Calesta Hui Yi Teo,Chang Liu,Isabelle Xin Yu Lee,Molly Tzu-Yu Lin,Fengyi Liu,Charmaine Jan Li Toh,Siew Kwan Koh,Da Qian Lu,Thomas Chuen Lam,Lei Zhou,Louis Tong,Jodhbir Mehta,Yu-Chi Liu
BACKGROUND/AIMS To identify the risk factors for neuropathic corneal pain (NCP) following corneal refractive surgery and to report its clinical manifestations, imaging and proteomic characteristics. METHODS This 1 year prospective cohort study included 100 eyes that underwent small incision lenticule extraction (SMILE) or laser-assisted in situ keratomileusis (LASIK). Ocular surface assessments, in-vivo
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Long-term visual outcomes and side effects of ruthenium plaque brachytherapy in 310 eyes with small choroidal melanoma. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-29 Beatrice Gallo,Rohan Hussain,Ranaa Al-Jamal,Hagar Khalid,Ian Stoker,Gordon Hay,Amit K Arora,Mandeep S Sagoo
BACKGROUND/AIMS To report the long-term visual outcomes and side effects in patients with small choroidal melanoma (CM) undergoing ruthenium-106 (Ru-106) plaque brachytherapy. METHODS Retrospective, interventional, consecutive series of small CM ≤2.5 mm in height and ≤16 mm in largest basal diameter treated with Ru-106 plaque with a median radiation dose of 100 Gy prescribed to tumour apical height
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New grading classification for paediatric atopic keratoconjunctivitis. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-29 Christopher Ashton,Daniel F P Larkin
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Change in subjective well-being and the associated costs of a woman-targeted presbyopia correction programme among older craftswomen in Zanzibar: a cost-outcome and scenario analysis. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-29 Ving Fai Chan,Omar Juma Othman,Ai Chee Yong,Christine Graham,Carlos Price-Sanchez,Bhagyalaxmi Shivalingam Pillai,Eleanor Holland,Emma McConnell,Jamison Jones,Adrianna Farmer,Michelle Fernandes Martins,Kajal Shah,Damaris Mulewa,Ronnie Graham,Eden Mashayo,Fatma Omar
BACKGROUND A pilot eyecare programme aimed to address the urgent eye health needs of older Zanzibari craftswomen. We investigated the impact of correcting presbyopia on their subjective well-being (SWB) 6 months post-correction and assessed the cost-effectiveness of a women-targeted presbyopia correction programme. METHODS This study involved Zanzibari craftswomen aged 40 and older with presenting
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Insights from 1096 clinical cases: pioneering a universal grading system for vernal keratoconjunctivitis management. Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-01-29 Ambika Chandrasekar,Shweta Agarwal,Gaurav Chauhan,Bhaskar Srinivasan,Varsha Bhambani Chavda,Geetha Iyer
AIM To analyse the clinical and demographic profiles of patients with vernal keratoconjunctivitis (VKC) and propose a grading for VKC based on corneal status and symptom periodicity rather than disease activity. METHODS Retrospective observational study from January 2015 to January 2020 in India. VKC grading was based on past/present clinical signs and frequency of symptoms rather than disease activity
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At a glance Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Frank Larkin
Critical Flicker Fusion Frequency was found to most precisely predict visual outcomes for keratoprosthesis candidates. It was found to outperform in diagnostic efficacy all ophthalmologic tests in current routine use, including B-scan ultrasound, flash visual evoked potentials, and fundus endoscopy. Large language models were found to be helpful in educating conjunctivitis patients, showing high correctness
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Advances in myopia control strategies for children Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Xiu Juan Zhang, Ebenezer Zaabaar, Amanda Nicole French, Fang Yao Tang, Ka Wai Kam, Clement C. Tham, Li Jia Chen, Chi Pui Pang, Jason C. Yam
Myopia has long been a global threat to public health. Timely interventions are likely to reduce the risk of vision-threatening complications. There are both established and rapidly evolving therapeutic approaches to slow myopia progression and/or delay its onset. The effective methods for slowing myopia progression include atropine eye-drops, defocus incorporated multiple segments (DIMS) spectacle
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Predicting visual outcomes in keratoprosthesis surgery with critical flicker fusion frequency, B-scan, visual electrophysiology and endoscopy Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Guangcan Xu, Haolan Qi, Qianwei He, Mingxiong Chen, Junxia Fu, Qun Wang, Biyue Chen, Qing Hua Yang, Yifei Huang, Shihui Wei, Liqiang Wang
Purpose This study evaluates the predictive power of the critical flicker fusion frequency (CFF) test for visual outcomes in keratoprosthesis (KPro) candidates, comparing its accuracy with B-scan ultrasound, flash visual evoked potentials (fVEP) and endoscopy. Methods The study included 42 patients (42 eyes) scheduled for KPro surgery with a median follow-up period of 6 months. The receiver operating
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Evaluating the effectiveness of large language models in patient education for conjunctivitis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Jingyuan Wang, Runhan Shi, Qihua Le, Kun Shan, Zhi Chen, Xujiao Zhou, Yao He, Jiaxu Hong
Aims To evaluate the quality of responses from large language models (LLMs) to patient-generated conjunctivitis questions. Methods A two-phase, cross-sectional study was conducted at the Eye and ENT Hospital of Fudan University. In phase 1, four LLMs (GPT-4, Qwen, Baichuan 2 and PaLM 2) responded to 22 frequently asked conjunctivitis questions. Six expert ophthalmologists assessed these responses using
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Association between long-term statin use and cataract surgery: a nationwide study on 505 105 cataract surgery patients Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Andrim Halili, Saranda Haxha, Bochra Zareini, Casper Lund-Andersen, Kathrine Kold Sørensen, Christian Torp-Pedersen, Talip E Eroglu, Casper Niels Bang
Aims To assess the association between statin use and cataract surgery according to different statin treatment durations in patients with different cardiovascular risk profiles. Methods and results We performed a nested case–control study using Danish registries, covering the period from 1 January 1996 to 31 December 2020. We defined cases as surgically treated cataract patients, matched in a 1:1 ratio
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Characterisation of delayed severity flares in patients with HLA-B27-associated anterior uveitis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Andrew M Philip, Fatima Babiker, Carla C Fernandez-Santos, Max N Chikovsky, Andrew H Dolinko, Koosha Ramezani, Sydney Look-Why, Ambika Manhapra, Maria L Ruggeri, Peter Y Chang, Stephen Foster, Stephen D Anesi
Background/aims To explore and characterise the clinical phenotype of acute anterior uveitis flares with delayed severity in patients with human leucocyte antigen B27 (HLA-B27)-associated anterior uveitis. Methods Retrospective chart review of patients with HLA-B27-associated anterior uveitis. Demographic and clinical data were recorded, as well as the clinical characteristics of acute anterior uveitis
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Choroidal involvement in acute retinal necrosis: case series and review of the literature Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Anamika Patel, Avinash Pathengay, Carlos Pavesio, Ilaria Testi
Purpose To show the role of multimodal imaging in identifying choroidal involvement in acute retinal necrosis (ARN). Methods Retrospective case series of ARN patients. Clinical data, including medical history, clinical features and multimodal imaging findings, were collected. Results Three patients were included. Imaging modalities, such as indocyanine green angiography and optical coherence tomography
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Visual outcomes and prognostic factors in ischaemic retinal vasculitis Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Aaron Yap, Helen Kearns, Joanne L Sims, Rachael L Niederer
Purpose Our aim was to describe the visual outcomes and determine the clinical factors in ischaemic retinal vasculitis (IRV) that were predictive of a poor visual prognosis or infectious aetiology. Methods Retrospective cohort study of consecutive presentations of IRV to Auckland District Health Board from 2009 to 2022. Results The median age at presentation was 39.2 years and 108 (53.7%) were women
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Comparison of subconjunctival TRIamcinolone acetonide injection and intravitreal dexamethasone (OZurdex) injection for uveitic and postoperative macular oedema: the TRIOZ study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Chloé Couret, Pierre-Antoine Quintart, Alexandra Poinas, Marie-Anne Vibet, Marie-Laure Le Lez, Pierre Labalette, Bahram Bodaghi, Marc Labetoulle, Marie-Bénédicte Rougier, Karine Angioi, Christophe Chiquet, Cherif Titah, Laurent Kodjikian, Stephanie Baillif, Catherine Creuzot-Garcher, Marie-Hélène Errera, Michel Weber
Aims To compare effectiveness of subconjunctival triamcinolone acetonide injections and intravitreal injections of dexamethasone 700 µg implants in reducing central macular thickness (CMT) in uveitic and postoperative macular oedema (ME). Methods We conducted an open-label, French multicentre randomised comparative trial with a logarithmic CMT non-inferiority margin set at 0.06. Patients were adults
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Sympathetic ophthalmia: epidemiology and cohort-based assessment of clinical outcomes Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Tim J Patterson, Weidong Gu, David Eliason, William Rojas-Carabali, Bernett Lee, Padmamalini Mahendradas, Jyotrimay Biswas, Parthopratim Dutta Majumder, Manisha Agarwal, Carlos Pavesio, Vishali Gupta, Rupesh Agrawal, Richard James Blanch
Background The purpose of this study was to report the incidence, time after inciting event, aetiology and risk after specific intraocular procedures and the visual outcomes associated with sympathetic ophthalmia (SO) occurrence. Methods This study reports data from multiple retrospective cohorts: retrospective population-based data were extracted from the TRICARE service network (between 2017 and
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Expert CONsensus on Visual Evaluation in Retinal disease manaGEment: the CONVERGE study Br. J. Ophthalmol. (IF 3.7) Pub Date : 2025-02-01 Roger S Anderson, Mark Roark, Rose Gilbert, Dayyanah Sumodhee
Background/Aims Recent decades have seen significant advances in both structural and functional testing of retinal disease. However, the current clinical value of specific testing modalities, as well as future trends, need to be clearly identified in order to highlight areas for further development in routine care and clinical trials. Methods We designed a modified two-round Delphi study to obtain