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Long-term outcomes of glued (sutureless) amniotic membrane transplantation in acute Stevens-Johnson syndrome/toxic epidermal necrolysis: a comparative study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-15 Ramy Rashad, James T Kwan, Swapna S Shanbhag, Panotsom Ngowyutagon, Musa Saeed, Mohammad A Tahboub, Abid Haseeb, James Chodosh, Hajirah N Saeed
Purpose To compare the effectiveness and efficiency of a glued (sutureless) technique for amniotic membrane transplantation (AMT) with a traditional sutured one in the setting of acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Methods This retrospective cohort study evaluated all patients diagnosed with SJS/TEN between 2008 and 2020 within our hospital network who received AMT
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Using artificial intelligence to improve human performance: efficient retinal disease detection training with synthetic images Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-14 Hitoshi Tabuchi, Justin Engelmann, Fumiatsu Maeda, Ryo Nishikawa, Toshihiko Nagasawa, Tomofusa Yamauchi, Mao Tanabe, Masahiro Akada, Keita Kihara, Yasuyuki Nakae, Yoshiaki Kiuchi, Miguel O Bernabeu
Background Artificial intelligence (AI) in medical imaging diagnostics has huge potential, but human judgement is still indispensable. We propose an AI-aided teaching method that leverages generative AI to train students on many images while preserving patient privacy. Methods A web-based course was designed using 600 synthetic ultra-widefield (UWF) retinal images to teach students to detect disease
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Validation of a deep learning model for automatic detection and quantification of five OCT critical retinal features associated with neovascular age-related macular degeneration Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-14 Federico Ricardi, Jonathan Oakley, Daniel Russakoff, Giacomo Boscia, Paolo Caselgrandi, Francesco Gelormini, Andrea Ghilardi, Giulia Pintore, Tommaso Tibaldi, Paola Marolo, Francesco Bandello, Michele Reibaldi, Enrico Borrelli
Purpose To develop and validate a deep learning model for the segmentation of five retinal biomarkers associated with neovascular age-related macular degeneration (nAMD). Methods 300 optical coherence tomography volumes from subject eyes with nAMD were collected. Images were manually segmented for the presence of five crucial nAMD features: intraretinal fluid, subretinal fluid, subretinal hyperreflective
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Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-12 Kohta Fujiwara, Emi Ueda, Jun Hata, Satoko Nakano, Sawako Hashimoto, Shun Nakamura, Yusuke Murakami, Toshiaki Kubota, Takeshi Yoshitomi, Toshiharu Ninomiya, Koh-Hei Sonoda
Aims To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. Methods We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of
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Dry eye symptoms and health-related quality of life among Chinese individuals: a national-based study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-12 Jia-Yan Kai, Yi-Bo Wu, Bing Shi, Dan-Lin Li, Xing-Xuan Dong, Pei Wang, Chen-Wei Pan
Aims To assess the impact of dry eye symptoms (DESs) on health-related quality of life (HRQOL) among Chinese residents. Methods A total of 21 916 participants were involved in this nationwide cross-sectional study. All of them completed the Ocular Surface Disease Index-6 and the five-level European Quality of Life 5-Dimensional (EQ-5D) Questionnaire to assess the severity of DES and HRQOL, respectively
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THYROID EYE DISEASE: PILOT STUDY COMPARISON BETWEEN PATIENTS IN UNITED STATES- BASED AND INDIA- BASED PRACTICES Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-12 Sathyadeepak Ramesh, Milind Naik, Alison Watson, Qiang Zhang, Ellen Peskin, James Sharpe, Kieran Alessi, Leslie Hyman
Thyroid eye disease (TED) phenotype varies by ethnicity/race and genetic/environmental factors. This study compared demographic and clinical characteristics of TED patients from the US and India. Observational pilot study 64 patients with TED ages ≥18 years old with active disease (onset of symptoms ≤18 months presenting clinical activity score (CAS) ≥4) were recruited between March and October 2021
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Reply to Comment on “Association between physical indicators and myopia in American adolescents: National Health and Nutrition Examination Survey 1999-2008” Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-12 Ninghong Chen, Yonghong Sheng, Guoping Wang, Jing Liu
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Influence of sutureless scleral fixation techniques with 3-piece IOLs on dislocation force Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-10 Johannes Zeilinger MD, Martin Kronschläger MD PhD MHBA, Andreas Schlatter MD, Manuel Ruiss MSc., Natascha Bayer MSc., Oliver Findl MD MBA
To compare four different secondary IOL fixation techniques regarding the least required force to dislocate a scleral fixated 3-piece IOL in human corneoscleral donor tissue (CST). Experimental Laboratory investigation The least required dislocation force (LRDF) of four different secondary IOL fixation techniques, namely the techniques using transscleral tunnels (TT, as described by Scharioth), glued
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Characteristics of Eyes with CRB1-associated EOSRD/LCA: Age-related changes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-10 Jad Ayash, Russell L. Woods, James D. Akula, Farrah Rajabi, Bilal K. AlWattar, Pablo Altschwager, Anne B. Fulton
To evaluate ocular and retinal features of -associated early onset severe retinal dystrophy/Leber congenital amaurosis (EOSRD/LCA) for age-related changes. Retrospective cohort study. Sixteen pediatric patients with biallelic EOSRD/LCA who had been followed for up to 18 years were reviewed. Results of comprehensive ophthalmic examinations—including visual acuity, refractive error, dark-adapted visual
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En Face and Volumetric Comparison of Hypertransmission Defects Evaluated by Cirrus and Spectralis Optical Coherence Tomography Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-09 Jiwon Baek, Maryam Ashrafkhorasani, Alireza Mahmoudi, Muneeswar Gupta Nittala, Giulia Corradetti, SriniVas R. Sadda
To evaluate and compare and 3-dimensional (D) properties of hypertransmission defects (HTDs) between different optical coherence tomography (OCT) devices using OCT volumes and reconstructed images. Comparative diagnostic evaluation study. Thirty eyes with dry age-related macular degeneration (AMD) that underwent dense OCT macular volume scans with both the Spectralis (97 B-scans/volume; 2,910 B-scans
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How gut microbiota may impact ocular surface homeostasis and related disorders Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-03-08 Marc Labetoulle, Christophe Baudouin, Jose M. Benitez del Castillo, Maurizio Rolando, Maria Rescigno, Elisabeth M. Messmer, Pasquale Aragona
Changes in the bacterial flora in the gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those with an inflammatory, neuronal, psychological or hormonal factor involved in the pathogenesis and/or the perception of the disease. Maintaining ocular surface homeostasis is also based on all these four factors, and there is accumulating
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Medial Canthal Collision Tumor with Seborrheic Keratosis Hiding Underlying Basal Cell Carcinoma Ophthalmology (IF 13.7) Pub Date : 2024-03-08 Wenyu Deng MD, Jodi Sassoon MD, Roman Shinder MD FACS
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Incidence of Blepharoptosis Following Intravitreal Anti-Vascular Endothelial Growth Factor Injections Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-08 Andrew Y. Lee BS, Kyle Kovacs MD, Anton Orlin MD, Szilard Kiss, Donald J. D'Amico MD, Kira L. Segal MD, Gary J. Lelli Jr. MD, Kyle J. Godfrey MD
We aimed to determine the incidence of blepharoptosis following intravitreal anti-vascular endothelial growth factor (VEGF) injections and compare the rates of blepharoptosis between patients injected with an eyelid speculum and those injected without a speculum. Retrospective cohort study International Classification of Diseases (ICD-10) was used to identify patients with exudative age-related macular
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Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-06 Hiroshi Kubota, Yoko Fukushima, Ryo Kawasaki, Takao Endo, Yoshikazu Hatsukawa, Hiromi Ineyama, Katsuya Hirata, Shinya Hirano, Kazuko Wada, Kohji Nishida
Background/aims We assessed the associations between retinopathy of prematurity (ROP) and continuous measurements of oxygen saturation (SpO2), and developed a risk prediction model for severe ROP using birth data and SpO2 data. Methods This retrospective study included infants who were born before 30 weeks of gestation between August 2009 and January 2019 and who were screened for ROP at a single hospital
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Exploring AI-chatbots’ capability to suggest surgical planning in ophthalmology: ChatGPT versus Google Gemini analysis of retinal detachment cases Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-06 Matteo Mario Carlà, Gloria Gambini, Antonio Baldascino, Federico Giannuzzi, Francesco Boselli, Emanuele Crincoli, Nicola Claudio D’Onofrio, Stanislao Rizzo
Background We aimed to define the capability of three different publicly available large language models, Chat Generative Pretrained Transformer (ChatGPT-3.5), ChatGPT-4 and Google Gemini in analysing retinal detachment cases and suggesting the best possible surgical planning. Methods Analysis of 54 retinal detachments records entered into ChatGPT and Gemini’s interfaces. After asking ‘Specify what
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Electroencephalogram-detected stress levels in the frontal lobe region of patients with dry eye Ocul. Surf. (IF 6.4) Pub Date : 2024-03-07 Minako Kaido, Reiko Arita, Yasue Mitsukura, Kazuo Tsubota
To evaluate stress levels extracted from prefrontal electroencephalogram (EEG) signals and investigate their relationship with dry eye symptoms. This prospective, cross-sectional, comparative study included 25 eyes of 25 patients with aqueous tear-deficient dry eye (low Schirmer group), 25 eyes of 25 patients with short tear breakup time dry eye (short breakup time group), and 24 eyes of 24 individuals
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Ocular Mucous Membrane Pemphigoid: The Effect of Risk Factors at Presentation on Treatment Outcomes. Ophthalmology (IF 13.7) Pub Date : 2024-03-06 Raul E. Ruiz-Lozano MD, Maria F. Colorado-Zavala MD, Eugenia M. Ramos-Dávila MD, Manuel E. Quiroga-Garza MD, Nadim S. Azar MD, Hazem M. Mousa MD, Julio C. Hernández-Camarena MD PhD, Sandra S. Stinnett DrPH, Melissa Daluvoy MD, Terry Kim MD, Maite Sainz-de-la-Maza MD, Russell P. Hall 3rd MD, Alejandro Rodriguez-Garcia MD, Victor L. Perez MD
Analyze the influence of risk factors at presentation in the long-term immunosuppressive therapy (IMT) outcomes of ocular mucous membrane pemphigoid (OMMP). Retrospective multicenter study. OMMP patients seen at Duke Eye Center, Tecnologico de Monterrey, and Hospital Clinic of Barcelona from 1990–2022. Data at presentation on demographics, direct immunofluorescence and ocular findings, extraocular
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A comparison of chemodnervation to incisional surgery for acute, acquired, comitant esotropia: An international study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-04 Crystal S.Y. Cheung, Michael J. Wan, David Zurakowski, Sylvia Kodsi, Noha S. Ekdawi, Heather C. Russell, Shashikant Shetty, Alina V. Dumitrescu, Linda R. Dagi, Ankoor S. Shah, David G. Hunter
To compare the efficacy of botulinum toxin injections to strabismus surgery in children with acute, acquired, comitant esotropia (ACE), and to investigate factors predicting success. International, multi-center non-randomized comparative study Setting: Cloud-based survey. Study population: Children aged 2-17 years who underwent a single surgical intervention for ACE. Interventions: Botulinum toxin
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Diagnostic accuracy of artificial intelligence based automated diabetic retinopathy screening in real-world settings: a systematic review and meta-analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-02 Sanil Joseph, Jerrome Selvaraj, Iswarya Mani, Thandavarayan Kumaragurupari, Xianwen Shang, Poonam Mudgil, Thulasiraj Ravilla, Mingguang He
To evaluate the diagnostic accuracy of artificial intelligence (AI)-based automated diabetic retinopathy (DR) screening in real-world settings. Systematic review and meta-analysis We conducted a systematic review of relevant literature from January 2012 to August 2022 using databases including PubMed, Scopus and Web of Science. The quality of studies was evaluated using Quality Assessment for Diagnostic
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Translocator protein (18 kDa) (Tspo) in the retina and implications for ocular diseases Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-03-01 Mandy Hector, Thomas Langmann, Anne Wolf
Translocator protein (18 kDa) (Tspo), formerly known as peripheral benzodiazepine receptor is a highly conserved transmembrane protein primarily located in the outer mitochondrial membrane. In the central nervous system (CNS), especially in glia cells, Tspo is upregulated upon inflammation. Consequently, Tspo was used as a tool for diagnostic imaging of neuroinflammation in the brain and as a potential
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Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia Ocul. Surf. (IF 6.4) Pub Date : 2024-03-01 Sofia De Arrigunaga, Sarah Wall, Despoina Theotoka, Asaf Friehmann, Matthew Camacho, Sander Dubovy, Anat Galor, Carol L. Karp
Chronic inflammation is a predisposing factor for metaplastic changes and ultimately dysplasia. We describe cases of OSSN occurring in the setting of chronic ocular surface inflammation. Sixteen eyes from 14 individuals were included from one ocular oncology clinic between 2010 and 2023. Patients presented with ocular surface squamous neoplasia (OSSN) in the setting of chronic inflammation. The diagnosis
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Gonioscopy-Assisted Transluminal Trabeculotomy Outcomes under Different Levels of Glaucoma Severity: a Multicenter, Comparative Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-01 Leopoldo Magacho, Cláudia Gomide Vilela de S. Franco, Eduardo Akio I, Ana Cláudia Alves Pereira, Bruno Teno, Francisco Lucena-Neto, Bruno M. Faria, Júlia Maggi Vieira, Marcos Pereira Vianello, Fábio N. Kanadani
To evaluate the outcomes of Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) under different levels of glaucoma severity. Retrospective, multicenter, before-and-after study. One eye from all POAG patients that underwent both Phaco-GATT or GATT stand-alone with 12 months of follow-up were included and divided according to glaucoma severity (mild – GI; moderate – GII and advanced – GIII) and the
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Association between age-related macular degeneration and risk of incident cancer Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-28 Junhee Park, Wonyoung Jung, Kyungdo Han, Bongseong Kim, Seung-Yeon Lee, Je Moon Yoon, Dong Hui Lim, Dong Wook Shin
Background/aims Age-related macular degeneration (AMD) and cancer may share similar risk factors, indicating possible common pathogenic pathways. We aimed to describe the site-specific cancer risk based on the relationship of AMD with visual disability (VD) status. Methods This was a population-based cohort study using data from the Korean National Health Insurance Service database (2009–2019) including
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Relationship of posterior peripheral corneal layers and the trabecular meshwork: an immunohistological and anatomical study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-28 Burçin Kepez Yildiz, Rui Freitas, Perla Filippini, Fatima Habroosh, Dalia G Said, Harminder Singh Dua, Prity Sahay
Background/Aim With the popularity of endothelial keratoplasty (EK) procedures, Descemet membrane (DM) EK and pre-Descemet EK, considerable work has been done on understanding the posterior corneal anatomy. Most of the information available relates to the central cornea. We evaluated the peripheral cornea to explore the immunohistological and anatomical relationship between the pre-Descemet layer (PDL)
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Diagnostic utility of point-of-care ultrasound and optical coherence tomography for papilloedema in children: a prospective pilot study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-27 Hannah H Chiu, Nouf Al-Farsi, Agnes M F Wong, Adrienne Davis, Mark O Tessaro, Michael J Wan
Background/Aims Papilloedema is an important sign of serious neurological disease, but it can be difficult to detect on funduscopy. The purpose of this study was to determine the diagnostic accuracy of point-of-care ultrasound (POCUS) and optical coherence tomography (OCT) for detecting papilloedema in children. Methods This was a prospective observational study at a tertiary care paediatric hospital
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“Inner choroidal fibrosis: An optical coherence tomography biomarker of severity in chronic central serous chorioretinopathy” Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-28 Saarang Hansraj, Jay Chhablani, Umesh Chandra Behera, Ritesh Narula, Raja Narayanan, Niroj Kumar Sahoo
To describe a potential biomarker termed as inner choroidal fibrosis in cases of chronic central serous chorioretinopathy presenting to a tertiary referral center. Observational case series. Five eyes of four patients with chronic central serous chorioretinopathy, were noted to have a grey-white subretinal lesion in the macula, which was analyzed with multimodal imaging. It was seen that the lesions
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Reproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-26 Jacqueline J O N van den Bosch, Vincenzo Pennisi, Harsha Laxmana Rao, Kaweh Mansouri, Robert Weinreb, Hagen Thieme, Michael B Hoffmann, Lars Choritz
Background Intraocular pressure (IOP) monitoring in glaucoma management is evolving with novel devices. We investigated the reproducibility of 24 hour profiles on two consecutive days and after 30 days of self-measurements via telemetric IOP monitoring. Methods Seven primary patients with open-angle glaucoma previously implanted with a telemetric IOP sensor in one eye underwent automatic measurements
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Automated identification of fleck lesions in Stargardt disease using deep learning enhances lesion detection sensitivity and enables morphometric analysis of flecks Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-26 Jasdeep Sabharwal, Tin Yan Alvin Liu, Bani Antonio-Aguirre, Mya Abousy, Tapan Patel, Cindy X Cai, Craig K Jones, Mandeep S Singh
Purpose To classify fleck lesions and assess artificial intelligence (AI) in identifying flecks in Stargardt disease (STGD). Methods A retrospective study of 170 eyes from 85 consecutive patients with confirmed STGD. Fundus autofluorescence images were extracted, and flecks were manually outlined. A deep learning model was trained, and a hold-out testing subset was used to compare with manually identified
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Phase 3 Randomized Clinical Trial of the Safety and Efficacy of Travoprost Intraocular Implant in Patients with Open-Angle Glaucoma or Ocular Hypertension Ophthalmology (IF 13.7) Pub Date : 2024-02-27 Steven R. Sarkisian, Robert E. Ang, Andy M. Lee, John P. Berdahl, Sebastian B. Heersink, James H. Burden, Long V. Doan, Kerry G. Stephens, Angela C. Kothe, Dale W. Usner, L. Jay Katz, Tomas Navratil
Evaluate the safety and intraocular pressure (IOP)-lowering efficacy of two models of the travoprost intraocular implant (fast-eluting [FE-implant] and slow eluting [SE-implant]) from one of two pivotal trials (GC-010). Phase 3, multicenter, randomized, double-masked, sham-controlled, non-inferiority trial. Subjects with open-angle glaucoma or ocular hypertension, using 0 to 3 IOP-lowering medications
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Risk of corneal graft rejection and vaccination: a matched case-control study from a United States integrated health care system Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-27 Jennifer H. Ku, Afshan A. Nanji, Julia E. Tubert, Cynthia Joe, Divya Srikumaran, Kevin L. Winthrop, Amanda E. Brunton, Ana Florea, Frederick Fraunfelder, Tsaiyu Tseng, Yi Luo
Data on vaccine-associated corneal transplant rejections are limited. We examined the association between graft rejection and vaccination. Matched case-control We used electronic health records to identify corneal transplant recipients between 01/2008 and 08/2022 at Kaiser Permanente Southern California. Cases were transplant recipients who experienced a graft rejection (outcome) during the study period
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Patterns and Disparities in Recorded Gonioscopy During Initial Glaucoma Evaluations in the United States Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-27 Lee Jun Hui, Yoo Kristy, Lung Khristina, Apolo Galo, Toy Brian, Sanvicente Carina, Xu Benjamin
To assess patterns in gonioscopy during initial glaucoma evaluations in the United States. Retrospective, case-control study. Patients undergoing initial glaucoma evaluation between 2009-2020 were identified in the Optum Clinformatics® DataMart. Initial evaluation was defined as: 1) glaucoma suspect, anatomical narrow angle (ANA), or primary/secondary glaucoma diagnosed by an ophthalmologist; 2) continuously
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The risk of optic neuritis following mRNA COVID-19 vaccination compared to COVID-19 infection and other vaccinations. Ophthalmology (IF 13.7) Pub Date : 2024-02-24 Priya Shukla, Neha Sharma, Jacqueline K. Shaia, Devon A. Cohen, Rishi P. Singh, Katherine E. Talcott
to determine the risk of optic neuritis (ON) after mRNA COVID-19 vaccine administration. U.S. National aggregate database retrospective cohort study Patients were placed into cohorts based on mRNA COVID-19 vaccination status (no vaccine and positive history of COVID-19 infection, one vaccine, or two vaccines received) from December 2020-June 2022. Two control cohorts were created with patients vaccinated
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Effect of a patient portal reminder message after no-show on appointment reattendance in ophthalmology: a randomized clinical trial Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Sarah Atta, Richard B. Brown, Lauren M. Wasser, Natasha Mayer, Julie Cassidy, Peggy J. Liu, Andrew M. Williams
To assess the efficacy of electronic health record (EHR) messaging for re-engaging patients with ophthalmology care after a missed appointment. Prospective, randomized clinical trial. The study setting was an academic ophthalmology department. The patient population comprised return patients age 18 years or older with an appointment “no show,” or missed appointment. Over two phases of recruitment,
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Corneal Guttae Alone Do Not Make A Diagnosis of Fuchs Endothelial Corneal Dystrophy Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Jayne S Weiss, Natalie A. Afshari
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Effects of deep optic nerve head structures on Bruch's membrane opening- minimum rim width and peripapillary retinal nerve fiber layer Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Mitsuki Kambayashi, Hitomi Saito, Makoto Araie, Nobuko Enomoto, Hiroshi Murata, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Aiko Iwase, Goji Tomita, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M Zangwill, Robert N Weinreb
To explore the effects of deep optic nerve head (ONH) structures on Bruch's membrane opening (BMO)-minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) in healthy eyes. Prospective cross-sectional study Two hundred five healthy eyes of 141 subjects (mean ± standard deviation of age and axial length (AXL): 46.9±10.0 years and 24.79±1.15 mm) were enrolled. Best fit multivariable
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Association of ocular manifestations of Marfan syndrome with cardiovascular complications Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Elaine M. Tran, Karen M. Wai, Andrea L. Kossler, Prithvi Mruthyunjaya, Ehsan Rahimy, Euna B. Koo
To evaluate associations between ocular manifestations of Marfan syndrome and cardiovascular complications. retrospective cohort study Setting: TriNetX Analytics platform, a federated health research network of aggregated deidentified electronic health record data of over 119 million patients. Study Population: Patients diagnosed with Marfan syndrome. Observation Procedure: Univariate logistic regression
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Ultra-Wide-Field Optical Coherence Tomography and Gaussian Curvature to Assess Macular and Paravascular Retinoschisis in High Myopia Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Qing Zhao, Xinyu Zhao, Yan Luo, Zhikun Yang
To evaluate the severity and related factors of macular retinoschisis (MRS) and paravascular retinoschisis (PVRS) in high myopia (HM) using ultra-wide-field optical coherence tomography (UWF-OCT) and a novel Gaussian curvature (K). A cross-sectional study. Patients diagnosed with HM in Peking Union Medical College Hospital were recruited between January 2022 and November 2022. The presence and severity
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Genetic landscape and prognosis of conjunctival melanoma in Chinese patients Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-21 Hanhan Shi, Hao Tian, Tianyu Zhu, Jie Chen, Shichong Jia, Chunyan Zong, Qili Liao, Jing Ruan, Shengfang Ge, Yamin Rao, Mei Dong, Renbing Jia, Yimin Li, Shiqiong Xu, Xianqun Fan
Aims Conjunctival melanoma (CoM) is a rare but highly lethal ocular melanoma and there is limited understanding of its genetic background. To update the genetic landscape of CoM, whole-exome sequencing (WES) and targeted next-generation sequencing (NGS) were performed. Methods Among 30 patients who were diagnosed and treated at Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School
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Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors Ocul. Surf. (IF 6.4) Pub Date : 2024-02-22 Michael E. Stern, Argyrios N. Theofilopoulos, Philipp Steven, Jerry Y. Niederkorn, Robert Fox, Margarita Calonge, Christof Scheid, Stephen C. Pflugfelder
The literature is filled with citations reporting an increased incidence of chronic dry eye disease, also known as keratoconjunctivitis sicca, in patients with systemic autoimmune diseases such as rheumatoid arthritis, Sjögren's Syndrome, systemic sclerosis and lupus. As the most environmentally exposed mucosal surface of the body, the conjunctiva constantly responds to environmental challenges which
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Comment on Large Language Models in Ophthalmology Scientific Writing: Ethical Considerations, Blurred Lines or Not at All?1 Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Dr Alexander James Cameron Jessup, Professor Minas Theodore Coroneo
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Clinical Course and Visual Outcomes of Papilledema in Pediatric Cerebral Venous Sinus Thrombosis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Jessica A. Sun, Tais Estrela, Ryan Gise
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Socioeconomic Disparities in Glaucoma Severity at Initial Diagnosis: A Nationwide EHR Cohort Analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Swarup S. Swaminathan, Felipe A. Medeiros
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Comparison of the biometric characteristics after long term implantation of iris-fixated phakic intraocular lens in explanted and non-explanted groups of eyes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Luis Izquierdo, Fiorella Casanova Imken, Pablo Larco, Jose Chauca, Maria A. Henriquez
To evaluate and compare the biometric characteristics of the anterior chamber of a group of patients with significant endothelial cell loss (ECL) that required phakic IOL (pIOL) explantation and a group of patients who did not fulfill the explantation criteria related to corneal decompensation. Retrospective consecutive interventional case series The study included all consecutive patients implanted
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European Glaucoma Society research priorities for glaucoma care Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-20 Augusto Azuara-Blanco, Noleen McCorry, Andrew J Tatham, Stelios Georgoulas, Panayiota Founti, Cedric Schweitzer, Frances Meier-Gibbons, Philippe Denis, Anja Tuulonen, Gauti Johannesson, José María Martínez de la Casa, Verena Prokosch, Dimitrios A Giannoulis, Luis Abegão Pinto, David Garway-Heath, Fotis Topouzis
Background/Aims The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe. Methods We used a three-phase method, including a two-round electronic Delphi
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At a glance Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Frank Larkin
The authors' fusion model method works as a helpful tool for improving pterygium detection and grading accuracy in the context of insufficient smartphone data in the absence of a mobile mature database. Collagen type XII, a regulator of corneal form and stability, is undetectable in Bowman’s layer of keratoconic corneas, suggesting a possible integral role in the pathogenesis of keratoconus. Disc damage
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New insights on the role of microRNAs in retinal Müller glial cell function Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Weijie Jiang, Siqi He, Logen Liu, Xia Meng, Jing Lu, Juan Li, Tuo Chen, Ying Xu, Qiguo Xiao, Ling Qi, Jia Zhang
MicroRNAs belong to the family of non-coding RNAs that participate in cell proliferation, cell death and development. The Müller glial cells are the inherent and specific neuroglia cells in the retinal organisation and play significant roles in retinal neuroprotection, organisational maintenance, inflammation and immunity, regeneration, and the occurrence and development of retinal diseases. However
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Accurate detection and grading of pterygium through smartphone by a fusion training model Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Yuwen Liu, Changsheng Xu, Shaopan Wang, Yuguang Chen, Xiang Lin, Shujia Guo, Zhaolin Liu, Yuqian Wang, Houjian Zhang, Yuli Guo, Caihong Huang, Huping Wu, Ying Li, Qian Chen, Jiaoyue Hu, Zhiming Luo, Zuguo Liu
Background/aims To improve the accuracy of pterygium screening and detection through smartphones, we established a fusion training model by blending a large number of slit-lamp image data with a small proportion of smartphone data. Method Two datasets were used, a slit-lamp image dataset containing 20 987 images and a smartphone-based image dataset containing 1094 images. The RFRC (Faster RCNN based
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Collagen type XII is undetectable in keratoconus Bowman’s layer Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Mohammed Rigi, Hyeck-Soo Son, Loren Moon, Mario Matthaei, Divya Srikumaran, Albert S Jun, Charles G Eberhart, Uri S Soiberman
Purpose Corneal biomechanical failure is the hallmark of keratoconus (KC); however, the cause of this failure remains elusive. Collagen type XII ( COL12A1 ), which localises to Bowman’s layer (BL), is thought to function in stress-bearing areas, such as BL. Given the putative protective role of COL12A1 in biomechanical stability, this study aims to characterise COL12A1 expression in all corneal layers
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Differentiating stages of functional vision loss from glaucoma using the Disc Damage Likelihood Scale and cup:disc ratio Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Heiko Philippin, Einoti Naino Matayan, Karin Marianne Knoll, Edith Macha, Sia Mbishi, Andrew Makupa, Cristóvão Daniel Matsinhe, Isac Vasco da Gama, Mário Jorge Monjane, Joyce Awum Ncheda, Francisco Alcides Francisco Mulobuana, Elisante Muna, Nelly Fopoussi Guylene, Gus Gazzard, Ana Patricia Marques, Peter Shah, David Macleod, William Makupa, Matthew J Burton
Background Glaucoma staging is critical for treatment planning but has rarely been tested in severe/end-stage disease. We compared the performance of the Disc Damage Likelihood Scale (DDLS) and cup:disc ratio (CDR) using a functional glaucoma staging system (GSS) as the reference standard. Methods Post hoc analysis of a randomised controlled trial at the Eye Department of Kilimanjaro Christian Medical
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Influence of choroidal microvasculature dropout on progressive retinal nerve fibre layer thinning in primary open-angle glaucoma: comparison of parapapillary β-zones and γ-zones Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Hye Seong Hwang, Eun Ji Lee, Jeong-Ah Kim, Seung Hyen Lee, Tae-Woo Kim
Background/aims To compare the influence of choroidal microvasculature dropout (cMvD) on progressive retinal nerve fibre layer (RNFL) thinning in glaucomatous eyes with parapapillary β-zones and γ-zones. Methods 294 eyes with primary open-angle glaucoma (POAG) and parapapillary atrophy (PPA) underwent optical coherence tomography (OCT) to determine the type of PPA and OCT angiography scanning of the
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Iris volume change with physiologic mydriasis to identify development of angle closure: the Zhongshan Angle Closure Prevention Trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Chimei Liao, Harry Quigley, Yuzhen Jiang, Shengsong Huang, Wenyong Huang, David Friedman, Paul J Foster, Mingguang He
Aims To assess dynamic change of iris area (Iarea) and volume (VOL) with physiologic pupil dilation for progression of primary angle closure suspects. Methods Participants underwent baseline examinations including gonioscopy and anterior segment OCT (AS-OCT) as part of the Zhongshan Angle Closure Prevention Trial. The AS-OCT images were obtained both in the dark and light. Progression was defined as
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Central visual field damage in glaucoma eyes with choroidal microvasculature dropout with and without high axial myopia Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Eleonora Micheletti, Nevin El-Nimri, Takashi Nishida, Sasan Moghimi, Jasmin Rezapour, Massimo A Fazio, Min Hee Suh, Christopher Bowd, Akram Belghith, Mark Christopher, Jost B Jonas, Robert N Weinreb, Linda M Zangwill
Purpose To characterise the relationship between a deep-layer microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with and without high axial myopia. Design Cross-sectional study. Methods Seventy-one eyes (49 patients) with high axial myopia and POAG and 125 non-highly myopic POAG eyes (97 patients) were enrolled. Presence, area and angular
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Long-term visual acuity outcomes following cataract surgery in eyes with ocular inflammatory disease Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Sapna Gangaputra, Craig Newcomb, Rebecca Armour, Dongseok Choi, Gui-shuang Ying, Sylvia Groth, Hosne Begum, Tonetta Fitzgerald, Pichaporn Artornsombudh, Ebenezer Daniel, Nirali Bhatt, Stephen Foster, Douglas Jabs, Grace Levy-Clarke, Robert Nussenblatt, James T Rosenbaum, H Nida Sen, Eric Suhler, Jennifer Thorne, Kurt Dreger, Jeanine Buchanich, John H Kempen
Purpose To evaluate the long-term visual acuity (VA) outcome of cataract surgery in inflammatory eye disease. Setting Tertiary care academic centres. Design Multicentre retrospective cohort study. Methods A total of 1741 patients with non-infectious inflammatory eye disease (2382 eyes) who underwent cataract surgery while under tertiary uveitis management were included. Standardised chart review was
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Assessment of choriocapillaris and choroidal vascular changes in posterior uveitis using swept-source wide-field optical coherence tomography angiography Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Meng Tian, Guodong Zeng, Martin Zinkernagel, Christoph Tappeiner, Sebastian Wolf, Marion R Munk
Purpose To evaluate choriocapillaris (CC) and choroidal vascular changes in patients with posterior uveitis using swept-source (SS) wide-field optical coherence tomography angiography (OCTA). Method Consecutive patients with posterior uveitis were evaluated using 3×3 mm and 12×12 mm OCTA scan patterns and montage images of 5×12×12 mm or 2×15×9 mm, covering approximately 70°–90° of the retina. The images
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Incidence and multimodal imaging characteristics of macular neovascularisation subtypes in Chinese neovascular age-related macular degeneration patients Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Yining Zhang, Yuhong Gan, Yunkao Zeng, Xuenan Zhuang, Xiongze Zhang, Yuying Ji, Yongyue Su, Feng Wen
Aims To investigate the incidence of macular neovascularisation (MNV) subtypes of neovascular age-related macular degeneration (nAMD) and summarise these subtypes’ clinical features in the Chinese population using multimodal imaging. Methods We retrospectively analysed 506 consecutive treatment-naïve nAMD patients (582 eyes). Incidence of MNV subtypes and clinical features were recorded based on their
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Acute posterior multifocal placoid pigment epitheliopathy: clinical presentation and risk of stroke and transient ischaemic attack Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Rachael L Niederer, Priya D Samalia, Yi-Hsing Chen, Jonathan KS Goh, Elisa Eleanor Cornish, Stephen Guest, Peter J McCluskey, Lyndell L Lim, Joanne L Sims, Susan Lightman, Oren Tomkins-Netzer
Background/aims Acute posterior multifocal placoid pigment epitheliopathy is a rare but important disease that can be associated with life-threatening complications due to cerebral vasculitis. The primary objective was to determine the incidence of neurological complications and risk factors for stroke and transient ischaemic attack (TIA) associated with acute posterior multifocal placoid pigment epitheliopathy
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Sympathetic nervous system activity is associated with choroidal thickness and axial length in school-aged children Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Senlin Lin, Bijun Zhu, Ting Wang, Hong Wang, Xian Xu, Shanshan Wang, Yao Yin, Zhaoyu Xiang, Yu Qian, Zhang Zhang, Lipu Cui, Haidong Zou, Xiangui He, Jianfeng Zhu, Yingyan Ma
Background/aims We aim to explore the effect of sympathetic nervous system (SNS) on choroid thickness (ChT) and axial length (AL). Methods Students of grade 2 and 3 from a primary school were included and followed for 1 year. Visual acuity, refraction, AL and ChT were measured. Morning urine samples were collected for determining SNS activity by analysing concentrations of epinephrine, norepinephrine