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Age–period–cohort analysis of the global burden of visual impairment according to major causes: an analysis of the Global Burden of Disease Study 2019 Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-25 Jianqi Chen, Yingting Zhu, Zhidong Li, Xiaohua Zhuo, Shaochong Zhang, Yehong Zhuo
Background Cataract, glaucoma and age-related macular degeneration (AMD) are major causes of visual impairment. As these are age-related conditions, the prevalence of associated visual impairment is anticipated to increase as the population ages. However, age–period–cohort effects on the disease burden have not been investigated. Methods This was a population-based study using aggregated data from
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Survival of medical treatment success in primary open-angle glaucoma and ocular hypertension Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-25 Dun Jack Fu, Ebenezer Ademisoye, Vanessa Shih, Andrew Ian McNaught, Anthony Khawaja
Background/aims Topical agents to lower intraocular pressure (IOP) are the most common initial therapeutic measure in glaucoma prevention. This study aims to assess treatment success duration among patients initiating or intensifying topical glaucoma medication. Methods Medical records (2013‒2018) for adults initiating/intensifying topical glaucoma medication were extracted from five secondary-care
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Prediction of retinopathy progression using deep learning on retinal images within the Scottish screening programme Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-24 Joseph Mellor, Wenhua Jiang, Alan Fleming, Stuart J McGurnaghan, Luke A K Blackbourn, Caroline Styles, Amos Storkey, Paul M McKeigue, Helen M Colhoun
Background/aims National guidelines of many countries set screening intervals for diabetic retinopathy (DR) based on grading of the last screening retinal images. We explore the potential of deep learning (DL) on images to predict progression to referable DR beyond DR grading, and the potential impact on assigned screening intervals, within the Scottish screening programme. Methods We consider 21 346
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Home-Monitoring Vision Tests to Detect Active Neovascular Age-Related Macular Degeneration JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-25 Ruth E. Hogg, Sobha Sivaprasad, Robin Wickens, Sean O’Connor, Eleanor Gidman, Elizabeth Ward, Charlene Treanor, Tunde Peto, Ben J. L. Burton, Paul Knox, Andrew J. Lotery, Michael Donnelly, Chris A. Rogers, Barnaby C. Reeves
ImportanceMost neovascular age-related macular degeneration (nAMD) treatments involve long-term follow-up of disease activity. Home-monitoring would reduce the burden on patients and their caregivers and release clinic capacity.ObjectiveTo evaluate 3 vision home-monitoring tests for patients to use to detect active nAMD compared with diagnosing active nAMD at hospital follow-up during the after-treatment
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Daily Low-Level Red Light for Spherical Equivalent Error and Axial Length in Children With Myopia JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-25 Kai Cao, Lei Tian, Dong-Li Ma, Shi-Qiang Zhao, Ao Li, Zi-Bing Jin, Ying Jie
ImportanceTreatments are needed to slow progression of or reduce incidence of myopia.ObjectiveTo evaluate the efficacy and safety of daily 650-nm low-level red light (LLRL) for myopia treatment.Design, Setting, and ParticipantsSingle-masked, randomized clinical trial at 1 site in China. Baseline measurements were completed from August to September 2021. Participants were children aged 6 to 12 years
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Place, Race, and Lapses in Diabetic Retinopathy Care JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-25 Tina Tang, Diep Tran, Dingfen Han, Scott L. Zeger, Deidra C. Crews, Cindy X. Cai
This cohort study investigates the association of neighborhood-level social determinants of health with lapses in diabetic retinopathy care by race and ethnicity.
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COVID-19 Vaccine–Associated Uveitis in Patients With a History of Uveitis JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-25 Jiyeong Kim, Hyeon Yoon Kwon, Seong Joon Ahn
ImportanceUnderstanding the potential risk of uveitis recurrence after COVID-19 vaccination in individuals with a history of uveitis is crucial for vaccination strategies and clinical monitoring.ObjectiveTo investigate the risk of uveitis recurrence after COVID-19 vaccination in a cohort of individuals with a history of uveitis.Design, Setting, and ParticipantsThis retrospective population-based cohort
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Effectiveness of repeated low-level red light in myopia prevention and myopia control Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-17 Guihua Liu, Hua Rong, Yipu Liu, Biying Wang, Bei Du, Desheng Song, Ruihua Wei
Background/aims To compare the effects of repeated low-level red light (RLRL) treatment on axial length growth and refractive error changes in myopic and premyopic children. Methods Subjects were assigned randomly to four subgroups: myopia-RLRL group (M-RL), myopia-control group (M-C), premyopia-RLRL group (PM-RL) and premyopia-control group (PM-C). Subjects in the RLRL group completed a 12-month treatment
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Morning Glory Syndrome in a Newborn Aged 2 Weeks JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Francesco Pozzo Giuffrida, Marco Nassisi, Silvia Osnaghi
This case report describes a diagnosis of morning glory syndrome in a 2-week-old infant who presented with divergent strabismus, cleft lip, and hypertelorism.
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Facial Swelling After External Dacryocystorhinostomy JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Tyler Herod, Rami Darwich, Ahsen Hussain
A 67-year-old woman underwent elective external dacryocystorhinostomy to treat symptomatic nasolacrimal duct obstruction and developed persistent cervicofacial swelling and ecchymoses of the eyelids and cheek. Head computed tomography revealed extensive emphysema throughout the soft tissues of the face and neck. What would you do next?
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Oral Sirolimus for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Amy Kalantary, Anne Halbert, Maria Franchina, Rachael C. Heath Jeffery, Rod O’Day, Fred K. Chen
This case report describes an 8-year-old girl who received oral sirolimus as an adjuvant therapy for pulse dye laser of her port-wine stain and as an off-label treatment of exudative retinal detachment secondary to diffuse choroidal hemangioma.
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Patching in Children With Unilateral Congenital Cataract and Child Functioning and Parenting Stress JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Carolyn Drews-Botsch, George Cotsonis, Marianne Celano, E. Eugenie Hartmann, Jaffer Zaidi, Scott R. Lambert
ImportanceParents may be concerned about the adverse outcomes of occlusion therapy in children treated for unilateral congenital cataract (UCC).ObjectiveTo determine whether occlusion therapy in children treated for UCC with poor visual outcomes is negatively associated with poorer child and/or family functioning.Design, Setting, and ParticipantsThis cohort study was conducted in 2023 using data collected
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Social history and glaucoma progression: the effect of body mass index, tobacco and alcohol consumption on the rates of structural change in patients with glaucoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-15 Asmaa A Youssif, Ndidi-Amaka Onyekaba, Rizul Naithani, Khaled Abdelazeem, Ahmed M Fathalla, Mohamed S Abdel‐Rhaman, Alessandro A Jammal, Felipe A Medeiros
Background/aims Although obesity, tobacco and alcohol consumption were linked to the progression of numerous chronic diseases, an association of these social history aspects with glaucoma progression is not yet determined. This study aims to investigate the effect of body mass index (BMI) and history of tobacco and alcohol use on the rates of retinal nerve fibre layer (RNFL) change over time in glaucoma
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Corrigendum to “New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering” [Ocul. Surf. 30 (October 2023) 204–212] Ocul. Surf. (IF 6.4) Pub Date : 2024-04-16 Swati Singh, Zoltan Winter, Fabian Necker, Tobias Bäuerle, Michael Scholz, Lars Bräuer, Friedrich Paulsen
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Readership awareness series – Paper 10: Open Access Publishing Ocul. Surf. (IF 6.4) Pub Date : 2024-04-16 Mohammad Javed Ali, Ali Djalilian
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Using Large Language Models to Generate Educational Materials on Childhood Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-04-16 Qais Dihan, Muhammad Z. Chauhan, Taher K. Eleiwa, Amr K. Hassan, Ahmed B. Sallam, Albert S. Khouri, Ta C. Chang, Abdelrahman M. Elhusseiny
To evaluate the quality, readability, and accuracy of large language model (LLM) generated patient education materials (PEMs) on childhood glaucoma, and their ability to improve existing online information's readability. Cross-sectional comparative study. We evaluated responses of ChatGPT-3.5, ChatGPT-4, and Bard to three separate prompts requesting they write PEMs on “childhood glaucoma.” Prompt A
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Relapse in ocular tuberculosis: relapse rate, risk factors and clinical management in a non-endemic country Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-12 Ikhwanuliman Putera, Josianne C. E. M. ten Berge, Alberta A. H. J. Thiadens, Willem A. Dik, Rupesh Agrawal, P. Martin van Hagen, Rina La Distia Nora, Saskia M. Rombach
Aims To assess the risk of uveitis relapse in ocular tuberculosis (OTB) following clinical inactivity, to analyse clinical factors associated with relapses and to describe the management strategies for relapses. Methods A retrospective study was conducted on a 10-year patient registry of patients with OTB diagnosed at Erasmus MC in Rotterdam, The Netherlands. Time-to-relapse of uveitis was evaluated
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Manhattan Vision Screening and Follow-up Study (NYC-SIGHT): a nested cross-sectional assessment of falls risk within a cluster randomised trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-12 Lisa A Hark, Yujia Wang, Prakash Gorroochurn, Phyllis R Simon, Stefania C Maruri, Desiree R Henriquez, Daniel F Diamond, Jason D Horowitz, Lisa Park, Qing Wang, James D Auran, Jailine Carrion, David S Friedman, Jeffrey L Liebmann, George A Cioffi, Noga Harizman
Background To investigate the feasibility of using the Stopping Elderly Accidents, Deaths and Injuries (STEADI) Falls Risk Tool Kit during community-based eye health screenings to assess falls risk of participants enrolled in the Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT). Methods Cross-sectional analysis of data from a 5-year prospective, cluster-randomised clinical trial conducted
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Predictive model for iris melanoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-12 Arun Singh, Alexander Melendez-Moreno, Jørgen Krohn, Emily C Zabor
To develop a predictive model for the diagnosis of iris melanoma. Methods Retrospective consecutive case series that included 100 cases of pathologically confirmed iris melanoma and 112 cases of Iris naevus, either pathological confirmation or documented stability of >1 year. Patient demographic data, features of clinical presentation, tumour characteristics and follow-up were collected. Iris melanoma
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Randomised clinical trial of extended depth of focus lenses for controlling myopia progression: Outcomes from SEED LVPEI Indian Myopia Study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-11 Manoj K Manoharan, Pavan K Verkicharla
Purpose To determine the efficacy of extended depth of focus (EDOF) contact lenses for controlling myopia progression in children through a 1-year randomised clinical trial. Methods A total of 104 children aged 7–15 years, with spherical equivalent refraction ≤−0.50 D, were randomly assigned to wear SEED 1 dayPure EDOF Mid contact lenses (n=48) or single vision spectacle lenses (n=56). Cycloplegic
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Influencing factors of effective lens position in patients with Marfan syndrome and ectopia lentis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-10 Xin Shen, Zexu Chen, WanNan Jia, Yalei Wang, Tianhui Chen, Yang Sun, Yongxiang Jiang
Aims The aim of this study was to analyse the effective lens position (ELP) in patients with Marfan syndrome (MFS) and ectopia lentis (EL). Methods Patients with MFS undergoing lens removal and primary intraocular lens (IOL) implantation were enrolled in the study. The back-calculated ELP was obtained with the vergence formula and compared with the theoretical ELPs. The back-calculated ELP and ELP
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Role of lens in early refractive development: evidence from a large cohort of Chinese children Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-10 Xiaotong Han, Ruilin Xiong, Ling Jin, Shuai Chang, Qianyun Chen, Decai Wang, Xiang Chen, Yabin Qu, Weijia Liu, Mingguang He, Ian Morgan, Yangfa Zeng, Yizhi Liu
Aims To document longitudinal changes in spherical equivalent refraction (SER) and related biometric factors during early refractive development. Methods This was a prospective cohort study of Chinese children, starting in 2018 with annual follow-ups. At each visit, children received cycloplegic autorefraction and ocular biometry measurements. Lens power (LP) was calculated using Bennett’s formula
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Access to Pediatric Eye Care by Practitioner Type, Geographic Distribution, and US Population Demographics JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-11 Nora E. Siegler, Hannah L. Walsh, Kara M. Cavuoto
ImportanceInvestigating disparities in service coverage of pediatric optometrists and pediatric ophthalmologists in relation to patient demographics will illuminate vulnerable populations and inform future interventions.ObjectiveTo characterize the geographic distribution of pediatric eye care practitioners and analyze its association with population demographics.Design, Setting, and ParticipantsIn
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Increased incidence of adult gonococcal keratoconjunctivitis at two tertiary eye hospitals in Western Europe: clinical features, complications and antimicrobial susceptibility Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-09 Alice L Milligan, Anna C Randag, Sybren Lekkerkerk, Helen Fifer
Background Gonorrhoea is on the rise: between 2021 and 2022, a 50% and a 33% increase in diagnoses was seen, respectively, in England and the Netherlands. A concurrent rise in gonococcal keratoconjunctivitis (GKC) is a serious concern due to the potentially devastating visual complications. Methods This is a retrospective case series of adult GKC from two Western European tertiary ophthalmology centres
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Diagnostic criteria of anterior segment swept-source optical coherence tomography to detect gonioscopic angle closure Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-09 Philip Yawen Guo, Xiulan Zhang, Fei Li, Chen Lin, Anwell Nguyen, Rei Sakata, Risa Higashita, Keiichiro Okamoto, Marco Yu, Makoto Aihara, Tin Aung, Shan Lin, Christopher Kai-Shun Leung
Aims To compare the diagnostic performance of 360° anterior segment optical coherence tomography assessment by applying normative percentile cut-offs versus iris trabecular contact (ITC) for detecting gonioscopic angle closure. Methods In this multicentre study, 394 healthy individuals were included in the normative dataset to derive the age-specific and angle location-specific normative percentiles
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Incidence and analysis of intraoperative complications in femtosecond laser-assisted cataract surgery: a large-scale cohort study to establish the learning curve Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-08 Xiaobo Zhang, Wen Xu, Xingchao Shentu, Peiqing Chen, Yibo Yu, Kairan Lai, Jiayong Li, Wei Wang, Xinyi Chen, Ke Yao
Aims To assess the safety of femtosecond laser-assisted cataract surgery (FLACS) based on surgical parameters and intraoperative complications analysis and to determine the length of the learning curve for FLACS. Methods A prospective consecutive cohort study was conducted on Chinese patients who underwent either FLACS (3289 cases) or contemporaneous conventional phacoemulsification cataract surgery
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Femtosecond laser-assisted astigmatic keratotomy versus toric IOL implantation for correcting astigmatism in cataract patients: a systematic review and meta-analysis with trial sequential analysis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-04 Wei-Ting Yen, Tzu-Heng Weng, Ting-Yi Lin, Ming-Cheng Tai, Yi-Hao Chen, Yu-Min Chang
Aims To compare the refractive and visual outcomes of femtosecond laser-assisted astigmatic keratotomy (FSAK) and toric intraocular lens (IOL) implantation for correcting astigmatism in cataract patients. Methods Studies were retrieved from the Ovid-Medline, EMBASE, Cochrane Central Register of Controlled Trials and Scopus which compared FSAK and toric IOL for astigmatism correction in cataract patients
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Structural and functional changes of binocular corneal innervation and ocular surface function after unilateral SMILE and tPRK Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-04 Qianwen Gong, Kaiyan Huang, Kexin Li, Yixuan Tong, Jian Zhao, Hui Wang, Zhiqiang Xu, Meng Lin, Fan Lu, Liang Hu
Aims To evaluate the bilateral changes in the sub-basal nerve plexus of the cornea and ocular surface function after unilateral small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (tPRK) procedures. Methods 34 patients were enrolled in the study and underwent unilateral SMILE (21 of 34 patients) or unilateral tPRK (13 of 34 patients). Complete ophthalmic examinations
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A practical approach to uveitis screening in children with juvenile idiopathic arthritis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-04 Ivan Foeldvari, Marcela Bohn, Harry Petrushkin, S Angeles Han, Regitze Bangsgaard, Joan Calzada-Hernández, Tamas Constantin, Joke H de Boer, Jesus Díaz-Cascajosa, Clive Edelsten, Mia Glerup, Helene Ingels, Sebastian Kramer, Elisabetta Miserocchi, Ellen Nordal, Rotraud K Saurenmann, Gabriele Simonini, Ameenat Lola Solebo, Jan Titz, Jordi Anton
Background Juvenile idiopathic arthritis (JIA)-associated uveitis typically presents as a silent chronic anterior uveitis and can lead to blindness. Adherence to current screening guidelines is hampered by complex protocols which rely on the knowledge of specific JIA characteristics. The Multinational Interdisciplinary Working Group for Uveitis in Childhood identified the need to simplify screening
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Digital Technology Use Among Older Adults With Vision Impairment JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Jonathan Thomas, Louay Almidani, Bonnielin K. Swenor, Varshini Varadaraj
ImportanceTelehealth has the potential to improve health for older adults, but many access disparities exist, including for those with vision impairment (VI).ObjectiveTo examine the associations between VI and digital technology access measures in US older adults.Design, Setting, and ParticipantsThis was a cross-sectional study that included Medicare beneficiaries 65 years and older. Beneficiary data
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Postoperative Inflammation After Anterior Segment Surgery JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Matthew Schulgit, Danny A. Mammo, Sunil K. Srivastava
A 71-year-old woman had 2 months of worsening vision and pain in her right eye. Examination revealed retrocorneal plaque, peaking of the pupil, and temporal prominent scleral vessels with inferotemporal scleral thinning. What would you do next?
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Mental Health Conditions Associated With Strabismus in a Diverse Cohort of US Adults JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Kimberly Jin, Inas F. Aboobakar, Mary C. Whitman, Isdin Oke
ImportanceGreater understanding of the association between strabismus and mental health conditions across sociodemographic backgrounds may inform strategies to improve mental well-being in this population.ObjectiveTo describe the association of strabismus with mental health conditions in a diverse cohort of US adults.Design, Setting, and ParticipantsThis cross-sectional study used data from the National
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Toward an internationally accepted standard for reading charts Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-04-02 Wolfgang Radner
Patients who suffer from sight-threatening eye diseases share a desire to regain a comfortable reading ability. In light of the modern advances achieved in ophthalmic diagnosis and therapy, and because a significant lack of comparability between reading charts still exists, there is an increasing need for a worldwide standard in the form of a norm for diagnostic reading charts. Already, applied advancements
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Reply Ophthalmology (IF 13.7) Pub Date : 2024-04-01 Ingrid U. Scott MD MPH, Neal L. Oden PhD, Paul C. VanVeldhuisen PhD, Michael S. Ip MD, Barbara A. Blodi MD
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Re: Scott et al.: SCORE2 Report 24: Nonlinear relationship of retinal thickness and visual acuity in central retinal and hemiretinal vein occlusion. (Ophthalmology. 2023;130:1066–1072) Ophthalmology (IF 13.7) Pub Date : 2024-04-01 Peng Wu MD, Rongyu Gao MD, Guangsen Liu MD
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Comparative analysis of human tear fluid and aqueous humor proteomes Ocul. Surf. (IF 6.4) Pub Date : 2024-03-30 August Beisel, Garrett Jones, Joshua Glass, Tae Jin Lee, Marc Töteberg-Harms, Amy Estes, Lane Ulrich, Kathryn Bollinger, Shruti Sharma, Ashok Sharma
Technological advancements allowing for the analysis of low-volume samples have led to the investigation of human tear fluid and aqueous humor (AH) as potential biomarker sources. However, acquiring AH samples poses significant challenges, making human tear fluid a more accessible alternative. This study aims to compare the protein compositions of these two biofluids to evaluate their suitability for
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Sudden Vision Loss JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-28 Archana A. Nair, Meredith E. Pugh, Edward F. Cherney
A 37-year-old woman was referred for evaluation of a retinal detachment in her left eye. Posterior examination results demonstrated a retinal detachment in the posterior pole with shifting fluid and no identifiable retinal break, and there was a thickened choroid with a hyporeflective band on ultrasound biomicroscopy. What would you do next?
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Bias Reduction Practices in Underrepresented Groups in Ophthalmology Resident Recruitment JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-28 Ogul E. Uner, Dongseok Choi, Thomas S. Hwang, Ambar Faridi
ImportanceBest recruitment practices for increasing diversity are well established, but the adoption and impact of these practices in ophthalmology residency recruitment are unknown.ObjectiveTo describe the adoption of bias reduction practices in groups underrepresented in ophthalmology (URiO) residency recruitment and determine which practices are effective for increasing URiO residents.Design, Setting
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Genetic Associations of Primary Angle-Closure Disease JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-28 Yu Jing Liang, Yu Yao Wang, Shi Song Rong, Zhen Ji Chen, Shu Ying Chen, Jenson A. Tham, Poemen P. Chan, Jason C. Yam, Janey L. Wiggs, Chi Pui Pang, Clement C. Tham, Li Jia Chen
ImportanceEffects of genetic variants on primary angle-closure disease remained uncertain.ObjectiveTo systematically review the associations of common single-nucleotide variants (SNVs) and rare coding variants with primary angle-closure disease, its subtypes (including primary angle-closure glaucoma, primary angle-closure suspect, and primary angle-closure) and progression.Data SourcesEligible studies
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Predictive performance of corneal and lid margin sensitivity for dry eye disease: An investigator-masked, prospective, prognostic accuracy study Ocul. Surf. (IF 6.4) Pub Date : 2024-03-28 Michael T.M. Wang, Jay J. Meyer, Ally L. Xue, Barry Power, Jennifer P. Craig
To evaluate the prognostic ability of non-contact esthesiometry corneal and lid margin sensitivity measurements in detecting symptoms and signs of dry eye disease, as defined by the global consensus TFOS DEWS II criteria. A total of 87 community residents (58 females; mean ± SD age, 53 ± 16 years) were recruited in an investigator-masked, prospective, prognostic accuracy study. Dry eye symptomology
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ICGA-GPT: report generation and question answering for indocyanine green angiography images Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-26 Xiaolan Chen, Weiyi Zhang, Ziwei Zhao, Pusheng Xu, Yingfeng Zheng, Danli Shi, Mingguang He
Background Indocyanine green angiography (ICGA) is vital for diagnosing chorioretinal diseases, but its interpretation and patient communication require extensive expertise and time-consuming efforts. We aim to develop a bilingual ICGA report generation and question-answering (QA) system. Methods Our dataset comprised 213 129 ICGA images from 2919 participants. The system comprised two stages: image–text
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Choriocapillaris flow features in children with myopic anisometropia Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-25 Zhihao Jiang, Wu Bo, Zhengfei Yang, Xiaoling Luo, Yao Ni, Junwen Zeng
Aims To examine differences between the eyes in choriocapillaris perfusion and choroidal thickness in children with myopic anisometropia. Methods In this observational and prospective study, 46 children with myopic anisometropia were enrolled. Choriocapillaris perfusion parameters, including the percentage of flow voids, the total number of flow voids and the average flow void area were obtained by
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Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2024-03-26 Ghazi O. Bou Ghanem, Lauren K. Wareham, David J. Calkins
Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain through the optic nerve. Glaucoma is associated with sensitivity to intraocular pressure (IOP). Thus, mainstay treatments seek to manage IOP, though many patients continue to lose vision. To address neurodegeneration directly
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Real-world application of a smartphone-based visual acuity test (WHOeyes) with automatic distance calibration Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-21 Yi Wu, Stuart Keel, Vera Lúcia Alves Carneiro, Shiran Zhang, Wei Wang, Chi Liu, Xuanzhang Tang, Xiaotong Han, Mingguang He
Background To develop and assess the usability of a smartphone-based visual acuity (VA) test with an automatic distance calibration (ADC) function, the iOS version of WHOeyes. Methods The WHOeyes was an upgraded version with a distinct feature of ADC of an existing validated VA testing app called V@home. Three groups of Chinese participants with different ages (≤20, 20–40, >40 years) were recruited
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Visual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-20 Jordan Loeliger, Dominique Monnet, Jennifer Thorne, Linda Imikerene, Souhila Kecili, Antoine P Brézin
Background Birdshot chorioretinitis (BSCR) is a chronic bilateral posterior uveitis, which can affect central as well as peripheral vision. The aim of this study was to assess how visual acuity and visual field evolved over time in patients with BSCR. Methods This was a prospective, observational, single-centre study based on data from the CO-BIRD cohort. Patient visits were categorised based on the
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Association of Occlusive Retinal Vasculitis With Intravitreal Faricimab JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-22 Ye Li, Robert Chong, Adrian T. Fung
This case report describes a patient with attenuation of retinal arterioles and veins associated with 2 blot hemorrhages and pallor of the inferotemporal retina without emboli.
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Laser in Situ Keratomileusis Flap Free-Floating on Interface Edema in Acute Corneal Hydrops JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Evan J. Warner
This case report describes a patient with a history of laser in situ keratomileusis who presented with pain, photophobia, and blurred vision secondary to a corneal flap free-floating on interface edema in the setting of acute hydrops.
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Clinical Features and Treatment Outcomes of Carbapenem-Resistant Pseudomonas aeruginosa Keratitis JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Felipe Echeverri Tribin, Caroline Lieux, Jorge Maestre-Mesa, Heather Durkee, Katherine Krishna, Brandon Chou, Emily Neag, Jana D’Amato Tóthová, Jaime D. Martinez, Harry W. Flynn, Jean Marie Parel, Darlene Miller, Guillermo Amescua
ImportanceEvaluation of the microbiological diagnostic profile of multidrug-resistant Pseudomonas aeruginosa keratitis and potential management with rose bengal–photodynamic antimicrobial therapy (RB-PDAT) is important.ObjectiveTo document the disease progression of carbapenemase-resistant P aeruginosa keratitis after an artificial tear contamination outbreak.Design, Setting, and ParticipantsThis retrospective
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Multifocal Unilateral Orange Fundus Tumors in a Young Man JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Bibhav Poudel, Vijitha S. Vempuluru, Carol L. Shields
A 38-year-old man had an asymptomatic, orange, macular choroidal mass with macular choroidal folds and a retinal pigment epithelial detachment in the right eye and a second orange mass nasal to the optic disc also in the right eye. What would you do next?
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Dystrophic Calcification in a 3-Piece Silicone Intraocular Lens JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Anvesh Annadanam, Boonkit Purt
This case report describes a diagnosis of dystrophic calcification of a silicone intraocular lens implant in a patient who presented with foggy vision and glare.
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Human Whole-Eye Donation for Research—Optimizing Clinical Trial Informed Consent JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Katrina A. Bramstedt
ImportancePosthumous whole-eye (globe) donations for research lack a mechanism that reinvolves the existing ophthalmic research team of the donor unless there is a preplanned donor directive. Disconnection between the deceased and their research team equates to lost opportunities for the research team to have a longitudinal view of the eyes that have been involved in their research.ObjectivesTo use
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Corneal Plug Keratoplasty for the Treatment of Small Corneal Perforation JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Xiaolin Qi, Hua Gao
This case report describes the performance of corneal plug keratoplasty in a male patient aged 30 years who presented with corneal perforation secondary to metal foreign body.
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New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis Ocul. Surf. (IF 6.4) Pub Date : 2024-03-21 Francesca Giovannetti, Marta Sacchetti, Marco Marenco, Ludovico Alisi, Giacomo Visioli, Alice Bruscolini, Alessandro Lambiase
To validate the use, repeatability, and reproducibility of a new, cost-effective, disposable, sterile device (KeraSenseⓇ, Dompè farmaceutici SpA, Milan Italy) compared to Cochet-Bonnet (CB) esthesiometer. Secondly, to identify a simple, safe, rapid, and low-cost test to diagnose neurotrophic keratitis (NK). 16 patients with diagnosis of NK stage I, 25 patients with diabetes mellitus (DM), and 26 healthy
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Prevalence of strabismus and risk factors in adults born preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Eye study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-19 Achim Fieß, Kim Dautzenberg, Sandra Gißler, Eva Mildenberger, Michael S Urschitz, Heike M Elflein, Panagiotis Laspas, Bernhard M Stoffelns, Norbert Pfeiffer, Alexander K Schuster
Aim The purpose of this study was to assess the prevalence of strabismus and nystagmus and to analyse associated factors in preterm and full-term infants in adulthood. Methods The Gutenberg Prematurity Eye Study is a retrospective cohort study with a prospective ophthalmological examination of participants born preterm and full-term (aged 18–52 years). Perinatal data were carefully assessed for risk
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Evaluation and model to achieve sex parity in cataract surgical coverage in Theni district, India Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-19 Sachin Gupta, Ravilla D Ravindran, Ashok Vardhan, Thulasiraj D Ravilla
Background/aims To propose an approach to determine the target ratio of cataract surgical rates (CSRs) of female to male subpopulations to increase sex parity in cataract surgical coverage (CSC), based on the sex gap in cataract burden and incidence, and demonstrate its application to Theni district, India. Methods A population-based longitudinal study between January 2016 and April 2018. We recruited
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One-year efficacy of myopia control by the defocus distributed multipoint lens: a multicentric randomised controlled trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-19 Xiaoqin Chen, Mengdi Li, Jun Li, Min Wu, Xiaonan Liu, Cui Yu, Xingyi Guo, Yanbo Wang, Yansong Wang, Wenli Lu, Lihua Li, Yan Wang
Aims To report the 1-year results of the efficacy of a defocus distributed multipoint (DDM) lens in controlling myopia progression in a multicentre, randomised controlled trial. Methods Overall, 168 children aged 6–13 years were recruited and randomly assigned to wear a DDM lens (n=84) or single-vision (SV) lens (n=84) in three centres. Cycloplegic autorefraction (spherical equivalent refraction (SER))
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At a glance Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-01 Frank Larkin
Optical coherence tomography can be used to image corneal ectasia which occurs late following penetrating keratoplasty. Corneas with late post-keratoplasty ectasia have a deeper anterior chamber, steeper graft-host interface angle, and lower thickness at the interface A deep learning algorithm was developed to predict nuclear age, which provides insight into the premature ageing of the lens nucleus
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Pan-Indian multicentre retrospective study of 0.01% atropine for myopia control Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-01 Jason C Yam, Yuzhou Zhang
The recent publication by Rohit et al evaluated the efficacy of 0.01% atropine in controlling myopia progression among Indian children over a 2-year period.1 A total of 732 myopic children aged 6–14 years from 20 centres were included, and all received 0.01% atropine eye-drops once daily. The authors found that, during the first year, there was a relative reduction of 64% in myopia progression, and
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Stargardt macular dystrophy and therapeutic approaches Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-01 Kaoru Fujinami, Nadia Waheed, Yannik Laich, Paul Yang, Yu Fujinami-Yokokawa, Joseph J Higgins, Jonathan T Lu, Darin Curtiss, Cathryn Clary, Michel Michaelides
Stargardt macular dystrophy (Stargardt disease; STGD1; OMIM 248200) is the most prevalent inherited macular dystrophy. STGD1 is an autosomal recessive disorder caused by multiple pathogenic sequence variants in the large ABCA4 gene (OMIM 601691). Major advances in understanding both the clinical and molecular features, as well as the underlying pathophysiology, have culminated in many completed, ongoing
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Characterisation of ectasia after penetrating keratoplasty in keratoconus eyes using anterior segment optical coherence tomography Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-04-01 Julia M Weller, Lisa Hübner, Friedrich E Kruse, Theofilos Tourtas
Background/aims Ectasia of the cornea can occur decades after penetrating keratoplasty (PK), especially in keratoconus eyes. The purpose of this study was to characterise ectasia after PK by morphological findings in anterior segment optical coherence tomography (AS-OCT). Methods In this retrospective, single-centre case series, 50 eyes of 32 patients with a history of PK at an average of 25±10 years