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Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity J. Med. Chem. (IF 6.8) Pub Date : 2025-02-11 Oscar Mammoliti, Rodrigo Carbajo, Laura Perez-Benito, Xiaodi Yu, Marion L. C. Prieri, Leonardo Bontempi, Sofie Embrechts, Ine Paesmans, Michela Bassi, Anindya Bhattacharya, Santiago Cañellas, Saskia De Hoog, Samuël Demin, Harrie J. M. Gijsen, Geerwin Hache, Tom Jacobs, Soufyan Jerhaoui, Joseph Leenaerts, Ferdinand H. Lutter, Michel Mahieu, Rosalie Matico, Robyn Miller, Daniel Oehlrich, Mathieu Perrier
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Ascertaining a Structural Basis in Drug Discovery and Development J. Med. Chem. (IF 6.8) Pub Date : 2025-02-11 David E. Heppner
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Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor J. Med. Chem. (IF 6.8) Pub Date : 2025-02-10 Jason D. Shields, David Baker, Amber Y. S. Balazs, Gayathri Bommakanti, Robert Casella, Shenggen Cao, Steve Cook, Randolph A. Escobar, Stephen Fawell, Francis D. Gibbons, Kathryn A. Giblin, Frederick W. Goldberg, Eric Gosselin, Tyler Grebe, Niresh Hariparsad, Holia Hatoum-Mokdad, Rachel Howells, Samantha J. Hughes, Anne Jackson, Iswarya Karapa Reddy, Jason G. Kettle, Gillian M. Lamont, Scott Lamont
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Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector J. Med. Chem. (IF 6.8) Pub Date : 2025-02-10 Elisa Romeo, Francesco Saccoliti, Riccardo Ocello, Angela Andonaia, Caterina Allegretta, Cristina Pastorino, Nicoletta Pedemonte, Federico Falchi, Onofrio Laselva, Tiziano Bandiera, Fabio Bertozzi
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Identification of Structurally Novel KRASG12C Inhibitors through Covalent DNA-Encoded Library Screening J. Med. Chem. (IF 6.8) Pub Date : 2025-02-10 David Huang, Francesco Manoni, Zhen Sun, Rongfeng Liu, Jennifer R. Allen, Abhisek Banerjee, Victor J. Cee, Josephine Eshon, Michael J. Frohn, Matthew R. Kaller, Heejun Lee, Cui Li, Xun Li, Patricia Lopez, Vu Ma, Jose M. Medina, Christopher Mohr, Olga A. Mukhina, Alexander J. Pickrell, John Stellwagen, Wenting Wu, Wenhan Zhang, Kai Zhu, Upendra P. Dahal, Liaoyuan A. Hu, Monica Leavitt, Wencui Li, Yu
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Directing autophagy to degrade cell surface receptors Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-10
Discover the world’s best science and medicine | Nature.com
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Structure Optimization of Natural Product Catalpol to Obtain Novel and Potent Analogs against Heart Failure J. Med. Chem. (IF 6.8) Pub Date : 2025-02-10 Hanfang Liu, Xiaobo Guo, Jin Yang, Conglong Xia, Yue Yao, Xiao Li, Xiaoyang Liu, Junqi Yang, Xiaokang Li, Yixiang Xu, Jian Li, Manjiong Wang
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Discovery of a Novel Selective and Cell-Active N6-Methyladenosine RNA Demethylase ALKBH5 Inhibitor J. Med. Chem. (IF 6.8) Pub Date : 2025-02-09 Xianyuan Yang, Kaitao Huang, Xu-Nian Wu, Chen Zhang, Yixuan Sun, Yanfeng Gao, Jiawang Zhou, Lijun Tao, Haisheng Zhang, Yinuo Wu, Hai-Bin Luo, Hongsheng Wang
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Guianensin, a Blackfly Salivary Protein, Inhibits the Lectin Pathway of Complement J. Med. Chem. (IF 6.8) Pub Date : 2025-02-09 Paola Carolina Valenzuela Leon, Molly E. Ring, Erika Nishiduka, Brian Bonilla, Phillip Cruz, Eduardo Patino Martinez, Caroline Percopo, Eric Calvo
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The strategy used by naïve anti-PEG antibodies to capture flexible and featureless PEG chains J. Control. Release (IF 10.5) Pub Date : 2025-02-10 Yiwei Liu, Takahiro Mori, Yusei Ito, Kimiko Kuroki, Seiichiro Hayashi, Daisuke Kohda, Taro Shimizu, Tatsuhiro Ishida, Steve R. Roffler, Mika K. Kaneko, Yukinari Kato, Takao Arimori, Takamasa Teramoto, Kazuhiro Takemura, Kenta Ishibashi, Yoshiki Katayama, Katsumi Maenaka, Yoshimitsu Kakuta, Akio Kitao, Takeshi Mori
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A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking J. Control. Release (IF 10.5) Pub Date : 2025-02-10 Yinying Pu, Yangying Duan, Wenhao Li, Han Lin, Qiyue Li, Binxu Yin, Kun Zhang, Bangguo Zhou, Wencheng Wu
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FDA approves TROP2-targeted antibody–drug conjugate for breast cancer Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-10
Discover the world’s best science and medicine | Nature.com
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A new European platform for advancing regulatory science research Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-10 Liese Barbier, Pierpaolo Moscariello, Hubert G Leufkens, Ralf Herold, Anna Maria Gerdina Pasmooij
Launching in 2025, the European Platform for Regulatory Science Research will bring together academia, regulators and other stakeholders to accelerate collaborative regulatory science research solutions.
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Albumin-based delivery systems: Recent advances, challenges, and opportunities J. Control. Release (IF 10.5) Pub Date : 2025-02-09 Gillian Murphy, David J. Brayden, David L. Cheung, Aaron Liew, Michael Fitzgerald, Abhay Pandit
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Biomimetic calcium-chelation nanoparticles reprogram tumor metabolism to enhance antitumor immunity J. Control. Release (IF 10.5) Pub Date : 2025-02-08 Zheng Wang, Ming Wu, Yingmeng Jiang, Junjie Zhou, Sai Chen, Qizhi Wang, Honghao Sun, Yueyang Deng, Zhanwei Zhou, Minjie Sun
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Controlled delivery of HIF-1α via extracellular vesicles with collagen-binding activity for enhanced wound healing J. Control. Release (IF 10.5) Pub Date : 2025-02-08 Sungmi Jeon, Seongeon Cho, Seongkyeong Yoo, Yeji Lee, Jiyoung Goo, Yu Jin Jeong, Gi-Hoon Nam, Hyun-Tae Shin, Jong-Wan Park, Cherlhyun Jeong, Sang Wha Kim, Iljin Kim, In-San Kim
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A step forwarded on the in vitro and in vivo validation of rifabutin-loaded liposomes for the management of highly virulent MRSA infections J. Control. Release (IF 10.5) Pub Date : 2025-02-08 Mariana P. Coelho, Jacinta O. Pinho, Sandra N. Pinto, Maria Manuela Gaspar
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NQO1-Activatable Circular Antisense Oligonucleotides for Tumor-Cell-Specific Survivin Gene Silencing and Antitumor Therapy J. Med. Chem. (IF 6.8) Pub Date : 2025-02-08 Xiaoran Zhao, Jianfei Xu, Xingxing Liang, Zhongyu Wang, Yuejie Zhu, Dongyang Guo, Jing Wang, Gubu Amu, Qian Wang, Zhenjun Yang, Xinjing Tang
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MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design J. Med. Chem. (IF 6.8) Pub Date : 2025-02-07 Kevin M. Cottrell, Douglas A. Whittington, Kimberly J. Briggs, Haris Jahic, Janid A. Ali, Alvaro J. Amor, Deepali Gotur, Matthew R. Tonini, Wenhai Zhang, Alan Huang, John P. Maxwell
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A Nurr1 Agonist Derived from the Natural Ligand DHI Induces Neuroprotective Gene Expression J. Med. Chem. (IF 6.8) Pub Date : 2025-02-07 Markus Egner, Romy Busch, Úrsula López-García, Max Lewandowski, Georg Höfner, Thomas Wein, Julian A. Marschner, Daniel Merk
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Discovery of New Nanomolar Selective IRAP Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2025-02-07 Ben He, Nour Bou Karroum, Ronan Gealageas, François-Xavier Mauvais, Sandrine Warenghem, Matthieu Roignant, Nicolas Kraupner, Bao Vy Lam, Nathalie Azaroual, Vincent Ultré, Alexandre Rech, Laetitia Lesire, Cyril Couturier, Florence Leroux, Peter van Endert, Benoit Deprez, Rebecca Deprez-Poulain
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Novel Indoleamine-2,3-Dioxygenase-Targeted Pt(IV) Prodrugs Regulate the Tumor Immune Microenvironment to Achieve Chemoimmunotherapy In Vitro and In Vivo J. Med. Chem. (IF 6.8) Pub Date : 2025-02-07 Zhe Li, Xiao-Meng Liu, Fei Tan, Jia-Qian Wang, Xin Qiao, Yu-Kuan Feng, Jing-Yuan Xu, Ji-Hui Hao
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Development of ASGR-Mediated Hepatocyte-Targeting Cytotoxic Drug Conjugates with CTSB-Cleavable Linkers Incorporating Succinimide and Succinic Acid Monoamide J. Med. Chem. (IF 6.8) Pub Date : 2025-02-07 Jingsheng Jiang, Sigang Jian, Feifei Lin, Zhuo Zhang, Qianqian Shen, Guozhang Long, Biyu Yang, Junzhen Lin, Yanfen Fang, Jian Ding, Jia Liu, Yi Chen, Youhong Hu
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Property-Based Design of Xanthine Derivatives as Potent and Orally Available TRPC4/5 Inhibitors for Depression and Anxiety J. Med. Chem. (IF 6.8) Pub Date : 2025-02-07 Zhaoxiang Song, Huaduan Liang, Chu Xue, Shuxian Wang, Younan Ren, Zhuang Zhang, Tifei Xu, Bo Niu, Mengmeng Song, Mengru Liu, Xu Qin, Jie Li, Xianya Zhao, Fang Zhao, Jianhua Shen, Zhengyu Cao, Kai Wang
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Artificial Intelligence in Natural Product Drug Discovery: Current Applications and Future Perspectives J. Med. Chem. (IF 6.8) Pub Date : 2025-02-06 Amit Gangwal, Antonio Lavecchia
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Fe(II)-Photoantibiotics for Potential Antibacterial, Antibiofilm, and Infective Wound Healing Applications in Rat Model J. Med. Chem. (IF 6.8) Pub Date : 2025-02-06 Ishwar Singh, Anjali Upadhyay, Arif Ali Mandal, Sukanta Saha, Pragya Pragya, Lipi Pradhan, Malay Nayak, Arnab Dutta, Ashish Kumar Agrawal, Sudip Mukherjee, Samya Banerjee
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Oxazole-Based Ferroptosis Inhibitors with Promising Properties to Treat Central Nervous System Diseases J. Med. Chem. (IF 6.8) Pub Date : 2025-02-06 Camilla Scarpellini, Greta Klejborowska, Caroline Lanthier, Ariane Toye, Karolina Musiałek, Emily Van San, Magali Walravens, Maya Berg, Behrouz Hassannia, Pieter Van der Veken, Hans De Winter, Tom Vanden Berghe, Koen Augustyns
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Small extracellular vesicles (sEVs) in pancreatic cancer progression and diagnosis J. Control. Release (IF 10.5) Pub Date : 2025-02-06 Reaid Hasan, Zhen Zhao, Yuanke Li, Yanli Liu, Yuanyuan Zhang, Kun Cheng
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Engineered Bdellovibrio bacteriovorus enhances antibiotic penetration and biofilm eradication J. Control. Release (IF 10.5) Pub Date : 2025-02-06 Ying Tang, Yang Chen, Yong-Dan Qi, Hui-Yi Yan, Wen-An Peng, Yu-Qiang Wang, Qian-Xiao Huang, Xin-Hua Liu, Jing-Jie Ye, Yun Yu, Xian-Zheng Zhang, Cui Huang
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Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis J. Control. Release (IF 10.5) Pub Date : 2025-02-07 Haihua Ji, Xiaochen Yan, Li Zhang, Lin Yang, Pengcheng Xie, Fengying Gu, Shuigen Bian, Hao Wan, Shaoping Nie
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Noninvasive assessment of a bioconductive patch for treating atrial fibrillation with magnetic resonance imaging J. Control. Release (IF 10.5) Pub Date : 2025-02-07 Adrian Tabora Dychiao, Ting-Hsuan Lu, Sheng-Yao Peng, Cheng Fan, Siyang Song, Chongyu Zhang, Minyao Wang, Sophia Shi, Jun Wu, Shu-Hong Li, Yen Chang, Hsing-Wen Sung, Ren-Ke Li
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BioJect: An in vitro platform to explore release dynamics of peptides in subcutaneous drug delivery. J. Control. Release (IF 10.5) Pub Date : 2025-02-07 David Li,Qin Qiuhua,Ayca Altay Benetti,Burcu Uner,Lyes Kahouadji,Matthias G Wacker
Predicting the release performance of subcutaneous (SC) drug formulations is challenging due to the complex interplay between physicochemical properties and the physiological microenvironment, which includes the extracellular matrix (ECM), fluid composition, and fluid availability, factors that collectively influence bioavailability and absorption rates. The ECM often acts as a bandpass filter modulated
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Cutting-edge biotherapeutics and advanced delivery strategies for the treatment of metabolic dysfunction-associated steatotic liver disease spectrum. J. Control. Release (IF 10.5) Pub Date : 2025-02-07 Juhyeong Hong,Yong-Hee Kim
Metabolic dysfunction-associated steatotic liver disease (MASLD), a condition with the potential to progress into liver cirrhosis or hepatocellular carcinoma, has become a significant global health concern due to its increasing prevalence alongside obesity and metabolic syndrome. Despite the promise of existing therapies such as thyroid hormone receptor-β (THR-β) agonists, PPAR agonists, FXR agonists
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A novel prostate cancer-specific fluorescent probe based on extracellular vesicles targeting STEAP1 applied in fluorescence guided surgery J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Jian-Xuan Sun, Qi-Dong Xia, Jin-Zhou Xu, Ye An, Si-Yang Ma, Jing-Yu Xu, Jia-Cheng Xiang, Chen-Qian Liu, Meng-Yao Xu, Si-Han Zhang, Yang Luan, Ke Tang, Shao-Gang Wang
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Dual-target nanotherapy for vascular endothelium and bone mesenchymal stem cells halt steroid-induced osteonecrosis of the femoral head progression J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Wenbo Yang, Qing Pan, Yizhong Peng, Yuxiang Hu, Yongzhi Cui, Zengwu Shao, Chunqing Meng, Hong Wang, Wei Huang
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Injectable mineralized hydrogel microspheres for accelerated osteocyte network reconstruction and intelligent bone regeneration J. Control. Release (IF 10.5) Pub Date : 2025-02-06 Pengcheng Xiao, Junyan Liu, Chengcheng Du, Shengwen Cheng, Senrui Liu, Jiacheng Liu, Jingdi Zhan, Zhuolin Chen, Yaji Yang, Yiting Lei, Wei Huang, Chen Zhao
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Restoring tumor antigenicity activates the “bystander” T cell immune cycle J. Control. Release (IF 10.5) Pub Date : 2025-02-06 Yifan Yang, Qiumin Yu, Haoyu Zhang, Yuchen Liu, Hexuan Wang, Ningyi Yang, Yulian Shi, Wanli Zhang, Zijie Wu, Shitong Huang, Wenbin Xie, Ran Duan, Qiuli Mao, Xupeiyao Shi, Zheng Gao, Xiaoning Wang, Hanlin Guo, Lingxiao Chen, Yi Han, Ximing Li, Xiangdong Gao
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Mitophagy in Neurodegenerative Diseases: Mechanisms of Action and the Advances of Drug Discovery J. Med. Chem. (IF 6.8) Pub Date : 2025-02-05 Panpan Yang, Wen Shuai, Xin Wang, Xiuying Hu, Min Zhao, Aoxue Wang, Yongya Wu, Liang Ouyang, Guan Wang
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Switching Roles─Exploring Concentration-Dependent Agonistic versus Antagonistic Behavior of Integrin Ligands J. Med. Chem. (IF 6.8) Pub Date : 2025-02-05 Beatrice Stefanie Ludwig, Nils Krautkremer, Stefano Tomassi, Salvatore Di Maro, Francesco Saverio Di Leva, Anke Benge, Markus Nieberler, Horst Kessler, Luciana Marinelli, Susanne Kossatz, Ute Reuning
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Peptide Double-Stapling and Arginine N-Glycosylation Triggered the Development of Therapeutic Antimicrobial Peptides Capable of Killing Drug-Resistant Bacteria in Mice J. Med. Chem. (IF 6.8) Pub Date : 2025-02-05 Xiang Li, Yanjiao Ding, Jingwen Xue, Yinxue Fu, Fang Yan, Nannan Song, Honggang Hu, Wei Cong, Zhiyuan Lu, Yulei Li
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Neutral LPAR1 Antagonists for the Treatment of Idiopathic Pulmonary Fibrosis J. Med. Chem. (IF 6.8) Pub Date : 2025-02-05 Xiaojing Wang
Despite significant advancements in the treatment options for idiopathic pulmonary fibrosis (IPF), the disease remains aggressive and incurable. This viewpoint summarizes the discovery of a neutral, potent, and selective lysophosphatidic acid receptor 1 antagonist for the treatment of IPF. The lead optimization without the cocrystal structure guidance is worth it to highlight.
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Call for Papers: Peptide Therapeutics J. Med. Chem. (IF 6.8) Pub Date : 2025-02-05 Sunanda Chatterjee
The traditional concept that drugs have to be small molecules has changed over a period of time. (1−3) Limitations of small molecule drugs like nonspecific interactions or the inability to inhibit large surface interactions have outweighed their several advantages, including low cost of production, easy administration, and facile cell permeability in several applications. Other drug alternatives include
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Designer proteins take the bite out of snake venom Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-06
Discover the world’s best science and medicine | Nature.com
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Research trends in the use of nanobodies for cancer therapy. J. Control. Release (IF 10.5) Pub Date : 2025-02-06 Jun Hou,Kejiang Du,Jinling Li,Zhenghui Li,Shaorui Cao,Shilin Zhang,Wenxing Huang,Heng Liu,Xiaomei Yang,Shuyang Sun,Shanzhao Mo,Tianyu Qin,Xilei Zhang,Shihua Yin,Xinyu Nie,Xiaoling Lu
Although there are many challenges in using nanobodies for treating various complex tumor diseases, including rapid renal clearance and the complex blood-brain barrier environment, nanobodies have shown great potential due to their high antigen affinity, excellent tumor penetration ability, and favorable safety profile. Since the discovery of the variable domain (VHH) of camelid heavy-chain antibodies
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Reactive Oxygen Species Inducing Triazolylpyridine-Based Ru(II)/Ir(III) Complexes for Therapeutically Enhanced Triple-Negative Breast Cancer Treatment J. Med. Chem. (IF 6.8) Pub Date : 2025-02-05 Utpal Das, Shanooja Shanavas, Meena Jayaprakash, Annamalai Senthil Kumar, Rajesh Kushwaha, Debasish Mondal, Suvendu Maity, Prasanta Ghosh, Binoy Kar, Samya Banerjee, Sudheer Shenoy P, Bipasha Bose, Priyankar Paira
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Structure–Activity Relationship Studies of DNA Methyltransferase 1 Monovalent Degraders J. Med. Chem. (IF 6.8) Pub Date : 2025-02-05 Chao Qian, Youngeun Lee, Yulin Han, Yue Zhong, Jujun Zhou, Joel Hrit, Ling Xie, Qin Chen, H. Ümit Kaniskan, Xian Chen, Scott Rothbart, Xiaodong Cheng, Yan Xiong, Jian Jin
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Targeting the “Undruggable”: Small-Molecule Inhibitors of Proliferating Cell Nuclear Antigen (PCNA) in the Spotlight in Cancer Therapy J. Med. Chem. (IF 6.8) Pub Date : 2025-02-04 Tiantian Wang, Zengtao Wang
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Smart self-transforming nano-systems for overcoming biological barrier and enhancing tumor treatment efficacy J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Jun Tao, Weiqing Ning, Wei Lu, Rui Wang, Hui Zhou, Hongru Zhang, Jiayi Xu, Shouju Wang, Zhaogang Teng, Lianhui Wang
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Latest advancements and trends in biomedical polymers for disease prevention, diagnosis, treatment, and clinical application J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Mingxia Jiang, Huapan Fang, Huayu Tian
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Nerve growth factor loaded hypotonic eye drops for corneal nerve repair J. Control. Release (IF 10.5) Pub Date : 2025-02-04 Yili Yao, Lei Wang, Jiangtao Ding, Xinyang Pan, Linxing Yang, Changrong Guo, Yuanhao Wang, Reinhard Gruber, Kaihui Nan, Lingli Li
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Polymer-based nanodrugs enhance sonodynamic therapy through epigenetic reprogramming of the immunosuppressive tumor microenvironment J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Lin Yu, Lulu Gao, Bing Liang, Lu Zhang, Min Wu, Jingjing Liu
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Dynamic versus static testing and in vivo mechanical performance of poly(glycolide-trimethylene carbonate-ε-caprolactone) delayed release implants J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Norman L. Ilich, Siamak Saifzadeh, Dietmar W. Hutmacher, Tim R. Dargaville
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Role of PEGylated lipid in lipid nanoparticle formulation for in vitro and in vivo delivery of mRNA vaccines J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Li Zhang, Brandon Yi Loong Seow, Ki Hyun Bae, Yue Zhang, Kuo-Chieh Liao, Yue Wan, Yi Yan Yang
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A dual-modified glucomannan polysaccharide selectively sequesters growth factors for skin tissue repair J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Xiaotong Hu, Daping Xie, Yuwei Li, Yiming Niu, Rongwei Tan, Zhending She, Chunming Wang
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Peptide blocks phase separation and oncogenic transcription Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-05
Discover the world’s best science and medicine | Nature.com
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Overcoming Immunotherapy Resistance in Hepatocellular Carcinoma by Targeting Myeloid IL-8/ CXCR2 Signaling. Mol. Ther. (IF 12.1) Pub Date : 2025-02-05 Tsz Tung Kwong,Zhewen Xiong,Yiling Zhang,Haoran Wu,Jianquan Cao,Patrick Pak-Chun Wong,Xiaoyu Liu,Jing Wang,Chi Hang Wong,Gary Man-Kit Tse,Joseph Jao-Yiu Sung,Jingying Zhou,Alfred Sze-Lok Cheng,Stephen Lam Chan
Durable response to immune checkpoint blockade (ICB) in hepatocellular carcinoma (HCC) are limited to a minority of patients, yet reliable biomarkers are still lacking. Inflammatory cytokines such as interleukin-8 (IL-8) are associated with HCC progression, and IL-8 is known as the chemoattractant for immunosuppressive myeloid cells. Therefore, we aim to elucidate the ICB resistance mechanisms mediated
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Mesenchymal stromal cell therapy: progress to date and future outlook. Mol. Ther. (IF 12.1) Pub Date : 2025-02-05 Wen Lu,Julie Allickson
In clinical trials, mesenchymal stromal/stem cells (MSC) have consistently demonstrated safety. However, demonstration of efficacy has been inconsistent and many MSC trials have failed to meet their efficacy endpoint. This disappointing reality is reflected by the limited number MSC therapies approved by regulatory agencies, despite the large number of MSC trials registered on clinicaltrials.gov. Notably
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Converting TCR-based chimeric antigen receptor STAR into dual-specific targeting receptor for cancer immunotherapy. Mol. Ther. (IF 12.1) Pub Date : 2025-02-05 Li Yu,Zhixiao Zhou,Hanyang Yu,Yue Liu,Daosheng Huang,Jiasheng Wang,Xin Lin
Chimeric Antigen Receptor (CAR) T cell therapy has achieved great success in treating hematopoietic malignancies, however, post-therapy relapse remains a challenge. Traditionally, multi-specific CAR engineering requires precise arrangement of single-chain variable fragments (scFvs), which can lead to aggregation issues when assembled linearly. In this study, we developed a novel chimeric receptor,
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Crystallization of supersaturated PEG-b-PLA for the production of drug-loaded polymeric micelles. J. Control. Release (IF 10.5) Pub Date : 2025-02-05 Morteza Rasoulianboroujeni,Rae Hyung Kang,Maraya Klukas,Glen S Kwon
In this study, we propose the "crystallization from supersaturated solution" method for producing drug-loaded polymeric micelles. This method involves the formation of solid drug-encapsulating crystals of a diblock copolymer through isothermal crystallization from a supersaturated solution of the copolymer in low molecular weight PEGs containing the drug, followed by dissolution of the crystals to