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Peptide RL-QN15 promotes wound healing of diabetic foot ulcers through p38 mitogen-activated protein kinase and smad3/miR-4482-3p/vascular endothelial growth factor B axis Burns Trauma (IF 5.3) Pub Date : 2023-11-17 Dandan Sun, Kun Guo, Naixin Liu, Yilin Li, Yuansheng Li, Yan Hu, Shanshan Li, Zhe Fu, Yinglei Wang, Yutong Wu, Yingxuan Zhang, Jiayi Li, Chao Li, Zhuo Wang, Zijian Kang, Jun Sun, Ying Wang, Xinwang Yang
Background Wound management of diabetic foot ulcers (DFUs) is a complex and challenging task, and existing strategies fail to meet clinical needs. Therefore, it is important to develop novel drug candidates and discover new therapeutic targets. However, reports on peptides as molecular probes for resolving issues related to DFUs remain rare. This study utilized peptide RL-QN15 as an exogenous molecular
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Extracellular vesicles modulate key signalling pathways in refractory wound healing Burns Trauma (IF 5.3) Pub Date : 2023-11-17 Bowen Yang, Yumeng Lin, Yibo Huang, Nanxi Zhu, Ying-Qiang Shen
Chronic wounds are wounds that cannot heal properly due to various factors, such as underlying diseases, infection or reinjury, and improper healing of skin wounds and ulcers can cause a serious economic burden. Numerous studies have shown that extracellular vesicles (EVs) derived from stem/progenitor cells promote wound healing, reduce scar formation and have significant advantages over traditional
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S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion Burns Trauma (IF 5.3) Pub Date : 2023-11-06 Yu Zhang, Yajuan Song, Jing Du, Wei Liu, Chen Dong, Zhaosong Huang, Zhe Zhang, Liu Yang, Tong Wang, Shaoheng Xiong, Liwei Dong, Yaotao Guo, Juanli Dang, Qiang He, Zhou Yu, Xianjie Ma
Background In plastic surgery, tissue expansion is widely used for repairing skin defects. However, low expansion efficiency and skin rupture caused by thin, expanded skin remain significant challenges in promoting skin regeneration during expansion. S100 calcium-binding protein A9 (S100A9) is essential in promoting wound healing; however, its effects on skin regeneration during tissue expansion remain
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CO2 fractional laser-assisted transdermal delivery of silk nanofiber carriers in a rabbit ear hypertrophic scar model Burns Trauma (IF 5.3) Pub Date : 2023-11-03 Yan Yang, Lutong Liu, Xiaojin Wu, Xue Wang, Qiang Lu, Zhen Zhang
Background Hypertrophic scars are skin fibrotic diseases, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. However, topical drug application for hypertrophic scars are unsatisfactory. The purpose of this study was to explore the permeability of silk nanofiber hydrogels (SNFs) loaded with rhodamine 6G (R6G) and rhodamine 110 (R110) mediated by CO2 fractional
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In vitro comparison of human plasma-based and self-assembled tissue-engineered skin substitutes: two different manufacturing processes for the treatment of deep and difficult to heal injuries. Burns Trauma (IF 5.3) Pub Date : 2023-10-30 Álvaro Sierra-Sánchez,Brice Magne,Etienne Savard,Christian Martel,Karel Ferland,Martin A Barbier,Anabelle Demers,Danielle Larouche,Salvador Arias-Santiago,Lucie Germain
Background The aim of this in vitro study was to compare side-by-side two models of human bilayered tissue-engineered skin substitutes (hbTESSs) designed for the treatment of severely burned patients. These are the scaffold-free self-assembled skin substitute (SASS) and the human plasma-based skin substitute (HPSS). Methods Fibroblasts and keratinocytes from three humans were extracted from skin biopsies
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Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis. Burns Trauma (IF 5.3) Pub Date : 2023-10-30 Yunwei Wang,Kuo Shen,Yulin Sun,Peng Cao,Jia Zhang,Wanfu Zhang,Yang Liu,Hao Zhang,Yang Chen,Shaohui Li,Chaolei Xu,Chao Han,Yating Qiao,Qingyi Zhang,Bin Wang,Liang Luo,Yunshu Yang,Hao Guan
Background Non-healing wounds are an intractable problem of major clinical relevance. Evidence has shown that dermal papilla cells (DPCs) may regulate the wound-healing process by secreting extracellular vesicles (EVs). However, low isolation efficiency and restricted cell viability hinder the applications of DPC-EVs in wound healing. In this study, we aimed to develop novel 3D-DPC spheroids (tdDPCs)
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Tailored biomedical materials for wound healing. Burns Trauma (IF 5.3) Pub Date : 2023-10-26 Wenhui Liu,Lihua Zu,Shanzheng Wang,Jingyao Li,Xiaoyuan Fei,Meng Geng,Chunlei Zhu,Hui Shi
Wound healing is a long-term, multi-stage biological process that mainly includes haemostatic, inflammatory, proliferative and tissue remodelling phases. Controlling infection and inflammation and promoting tissue regeneration can contribute well to wound healing. Smart biomaterials offer significant advantages in wound healing because of their ability to control wound healing in time and space. Understanding
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P-MSC-derived extracellular vesicles facilitate diabetic wound healing via miR-145-5p/ CDKN1A-mediated functional improvements of high glucose-induced senescent fibroblasts Burns Trauma (IF 5.3) Pub Date : 2023-10-18 Jianlong Su, Qian Wei, Kui Ma, Yaxi Wang, Wenzhi Hu, Hao Meng, Qiankun Li, Yuehou Zhang, Wenhua Zhang, Haihong Li, Xiaobing Fu, Cuiping Zhang
Background Persistent hyperglycaemia in diabetes causes functional abnormalities of human dermal fibroblasts (HDFs), partially leading to delayed skin wound healing. Extracellular vesicles (EVs) containing multiple pro-healing microRNAs (miRNAs) have been shown to exert therapeutic effects on diabetic wound healing. The present study aimed to observe the effects of EVs derived from placental mesenchymal
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The m6A reader YTHDF2 alleviates the inflammatory response by inhibiting IL-6R/JAK2/STAT1 pathway-mediated high-mobility group box-1 release Burns Trauma (IF 5.3) Pub Date : 2023-10-16 Zhuo Zeng, Yingying Lan, Lijuan Zhang, Yu Chen, Yali Gong, Fangqing Zuo, Junda Li, Gaoxing Luo, Yizhi Peng, Zhiqiang Yuan
Background Sepsis is a common severe complication in major burn victims and is characterized by a dysregulated systemic response to inflammation. YTH domain family 2 (YTHDF2), a well-studied N6-methyladenosine (m6A) reader that specifically recognizes and binds to m6A-modified transcripts to mediate their degradation, is connected to pathogenic and physiological processes in eukaryotes, but its effect
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A photoactivatable and phenylboronic acid-functionalized nanoassembly for combating multidrug-resistant gram-negative bacteria and their biofilms Burns Trauma (IF 5.3) Pub Date : 2023-10-16 Xiaoqing Zhou, Lanlan Dong, Baohua Zhao, Guangyun Hu, Can Huang, Tengfei Liu, Yifei Lu, Mengxue Zheng, Yanlan Yu, Zengjun Yang, Shaowen Cheng, Yan Xiong, Gaoxing Luo, Wei Qian, Rui Yin
Background Multidrug-resistant (MDR) gram-negative bacteria-related infectious diseases have caused an increase in the public health burden and mortality. Moreover, the formation of biofilms makes these bacteria difficult to control. Therefore, developing novel interventions to combat MDR gram-negative bacteria and their biofilms-related infections are urgently needed. The purpose of this study was
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Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis Burns Trauma (IF 5.3) Pub Date : 2023-10-16 Ruzhen Zhang, Sheng Chen, Zhifan Yang, Ning Zhang, Kenan Guo, Keyi Lv, Zimo Zhou, Meijiao Gao, Xiancheng Hu, Yongping Su, Jianming He, Fengchao Wang
Background The rapid turnover of the intestinal epithelium is driven by the proliferation and differentiation of intestinal stem cells (ISCs). The dynamics of the F-actin cytoskeleton are critical for maintaining intercellular force and the signal transduction network. However, it remains unclear how direct interference with actin polymerization impacts ISC homeostasis. This study aims to reveal the
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Cell electrospinning and its application in wound healing: principles, techniques and prospects. Burns Trauma (IF 5.3) Pub Date : 2023-09-15 Zonghao Hu,Zishun Qin,Yue Qu,Feng Wang,Benheng Huang,Gaigai Chen,Xiaoyuan Liu,Lihua Yin
Currently, clinical strategies for the treatment of wounds are limited, especially in terms of achieving rapid wound healing. In recent years, based on the technique of electrospinning (ES), cell electrospinning (C-ES) has been developed to better repair related tissues or organs (such as skin, fat and muscle) by encapsulating living cells in a microfiber or nanofiber environment and constructing 3D
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Sustained induction of IP-10 by MRP8/14 via the IFNβ-IRF7 axis in macrophages exaggerates lung injury in endotoxemic mice. Burns Trauma (IF 5.3) Pub Date : 2023-09-11 Juan Wang,Guiming Chen,Lei Li,Sidan Luo,Bingrong Hu,Jia Xu,Haihua Luo,Shan Li,Yong Jiang
Background As a damage-associated molecular pattern, the myeloid-related protein 8/14 (MRP8/14) heterodimer mediates various inflammatory diseases, such as sepsis. However, how MRP8/14 promotes lung injury by regulating the inflammatory response during endotoxemia remains largely unknown. This study aims at illuminating the pathological functions of MRP8/14 in endotoxemia. Methods An endotoxemic model
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Cellular and molecular mechanisms in vascular repair after traumatic brain injury: a narrative review Burns Trauma (IF 5.3) Pub Date : 2023-09-05 Zi-Ai Zhao, Lingli Yan, Jing Wen, Senthil Kumaran Satyanarayanan, Feng Yu, Jiahong Lu, Yong U Liu, Huanxing Su
Traumatic brain injury (TBI) disrupts normal brain function and is associated with high morbidity and fatality rates. TBI is characterized as mild, moderate or severe depending on its severity. The damage may be transient and limited to the dura matter, with only subtle changes in cerebral parenchyma, or life-threatening with obvious focal contusions, hematomas and edema. Blood vessels are often injured
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Children’s growth and motor development following a severe burn: a systematic review Burns Trauma (IF 5.3) Pub Date : 2023-08-31 Maxime D Cuijpers, Martin G A Baartmans, Paul P M van Zuijlen, Johannes C F Ket, Anouk Pijpe
Background The epidemiological data on post-burn growth, body composition and motor development is ambiguous and scattered. The aim of this systematic review was therefore to summarize the current body of evidence on post-burn growth, body composition and motor development in children. Methods A literature search was conducted in PubMed, EMBASE and Web of Science up to March 2021. We considered observational
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Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers Burns Trauma (IF 5.3) Pub Date : 2023-08-20 Hengyu Du, Shenghong Li, Jinqiang Lu, Lingzhi Tang, Xiao Jiang, Xi He, Jiaji Liang, Xuan Liao, Taixing Cui, Yuesheng Huang, Hongwei Liu
Background Angiogenesis is crucial in diabetic wound healing and is often impaired in diabetic foot ulcers (DFUs). Human dermal microvascular endothelial cells (HDMECs) are vital components in dermal angiogenesis; however, their functional and transcriptomic characteristics in DFU patients are not well understood. This study aimed to comprehensively analyse HDMECs from DFU patients and healthy controls
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p53 promotes the expansion of regulatory T cells via DNMT3a- and TET2- mediated Foxp3 expression in sepsis Burns Trauma (IF 5.3) Pub Date : 2023-08-09 Hui Zhang, Tiantian Wu, Chao Ren, Ning Dong, Yao Wu, Yongming Yao
Background Immunosuppression is an important characteristic of sepsis and is closely related to poor outcomes. Regulatory T cells (Tregs) contribute to immune suppression by inhibiting effector T cell (Teff) proliferation and differentiation. We aimed to investigate the role of p53 in Treg expansion after sepsis. Methods We constructed a sepsis model in wild-type (WT) and p53f/f/CD4-Cre+ mice by cecal
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Skin models of cutaneous toxicity, transdermal transport and wound repair Burns Trauma (IF 5.3) Pub Date : 2023-07-28 Inês Vilela de Sousa, Miguel J S Ferreira, Luís B Bebiano, Sandra Simões, Ana Filipa Matos, Rúben F Pereira, Pedro L Granja
Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive molecules. However, the barrier properties of the skin, along with its multilayer structure, impose severe restrictions on drug transport and bioavailability. Thus, bioengineered models aimed at emulating the skin have been developed not only
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CD9 negatively regulates collective electrotaxis of the epidermal monolayer by controlling and coordinating the polarization of leader cells Burns Trauma (IF 5.3) Pub Date : 2023-07-24 Xiaoqiang Liu, Jinrui Yang, Meng Kong, Min Jiang, Luojia Liu, Jinghong Zhang, Ying Chen, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jie Liu, Jiaping Zhang
Background Endogenous electric fields (EFs) play an essential role in guiding the coordinated collective migration of epidermal cells to the wound centre during wound healing. Although polarization of leadercells is essential for collective migration, the signal mechanisms responsible for the EF-induced polarization of leader cells under electrotactic collective migration remain unclear. This study
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Vascularized lymph node flaps can survive on venous blood without an arterial inflow: an experimental model describing the dynamics of venous flow using indocyanine green angiography (With video) Burns Trauma (IF 5.3) Pub Date : 2023-07-19 Ke Li, Fabio Nicoli, Chunxiao Cui, Yan Wo, Ning Fei Liu, Shaoqing Feng, Wenjing Xi, Peiru Min, Yixin Zhang
Background Several surgeons have described studies of free-tissue transfers using veins instead of arteries. These innovative microsurgical techniques can offer several advantages, such as an easier dissection during flap harvesting, and represent an alternative during an accidental surgical mistake or development of new surgical procedures. The purpose of this study was to describe and explore different
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Mitochondrial dysfunction and mitophagy: crucial players in burn trauma and wound healing Burns Trauma (IF 5.3) Pub Date : 2023-07-17 Harshini Sheeja Prabhakaran, Dongxue Hu, Weifeng He, Gaoxing Luo, Yih-Cherng Liou
Burn injuries are a significant cause of death worldwide, leading to systemic inflammation, multiple organ failure and sepsis. The progression of burn injury is explicitly correlated with mitochondrial homeostasis, which is disrupted by the hyperinflammation induced by burn injury, leading to mitochondrial dysfunction and cell death. Mitophagy plays a crucial role in maintaining cellular homeostasis
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Wnt4 increases the thickness of the epidermis in burn wounds by activating canonical Wnt signalling and decreasing the cell junctions between epidermal cells. Burns Trauma (IF 5.3) Pub Date : 2023-07-03 Fei Xiang,Pei Wang,Hao Gong,Jia Luo,Xin Zhou,Chenglin Zhan,Tianxing Hu,Mengru Wang,Yizhan Xing,Haiying Guo,Gaoxing Luo,Yuhong Li
Background Burn wound healing is a complex process and the role of Wnt ligands varies in this process. Whether and how Wnt4 functions in burn wound healing is not well understood. In this study, we aim to reveal the effects and potential mechanisms of Wnt4 in burn wound healing. Methods First, the expression of Wnt4 during burn wound healing was determined by immunofluorescence, Western blotting and
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A volar skin excisional wound model for in situ evaluation of multiple-appendage regeneration and innervation Burns Trauma (IF 5.3) Pub Date : 2023-06-29 Huanhuan Gao, Yiqiong Liu, Ziwei Shi, Hongliang Zhang, Mengyang Wang, Huating Chen, Yan Li, Shaifei Ji, Jiangbing Xiang, Wei Pi, Laixian Zhou, Yiyue Hong, Lu Wu, Aizhen Cai, Xiaobing Fu, Xiaoyan Sun
Background Promoting rapid wound healing with functional recovery of all skin appendages is the main goal of regenerative medicine. So far current methodologies, including the commonly used back excisional wound model (BEWM) and paw skin scald wound model, are focused on assessing the regeneration of either hair follicles (HFs) or sweat glands (SwGs). How to achieve de novo appendage regeneration by
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Notch4 participates in mesenchymal stem cell-induced differentiation in 3D-printed matrix and is implicated in eccrine sweat gland morphogenesis Burns Trauma (IF 5.3) Pub Date : 2023-06-29 Yuzhen Wang, Fanliang Zhang, Bin Yao, Linhao Hou, Zhao Li, Wei Song, Yi Kong, Yaxin Tan, Xiaobing Fu, Sha Huang
Background Eccrine sweat gland (SG) plays a crucial role in thermoregulation but exhibits very limited regenerative potential. Although SG lineage-restricted niches dominate SG morphogenesis and benefit SG regeneration, rebuilding niches in vivo is challenging for stem cell therapeutic applications. Hence, we attempted to screen and tune the critical niche-responding genes that dually respond to both
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Postbiotics as potential new therapeutic agents for sepsis Burns Trauma (IF 5.3) Pub Date : 2023-06-16 Xiran Lou, Jinfang Xue, Ruifei Shao, Chunyan Mo, Fuping Wang, Guobing Chen
Sepsis is the main cause of death in critically ill patients and gut microbiota dysbiosis plays a crucial role in sepsis. On the one hand, sepsis leads to the destruction of gut microbiota and induces and aggravates terminal organ dysfunction. On the other hand, the activation of pathogenic gut flora and the reduction in beneficial microbial products increase the susceptibility of the host to sepsis
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Using Zhang’s supertension-relieving suture technique with slowly-absorbable barbed sutures in the management of pathological scars: a multicenter retrospective study Burns Trauma (IF 5.3) Pub Date : 2023-06-16 Peiru Min, Shunuo Zhang, Dorsa Gholamali Sinaki, Ping Yao, Fuhua Hu, Xin Wang, Danya Zhou, Jun Chai, Yixin Zhang
Background An ideal tension-relieving suture should be efficient for >3 months to retrieve normal tensile strength. Most preexisting suturing techniques provided tension elimination followed by relapse and scar proliferation due to absorption and cut-through of the sutures. This study introduces a simple but effective suture technique developed by a senior author (ZYX) to solve this problem. Methods
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Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics Burns Trauma (IF 5.3) Pub Date : 2023-06-09 Yijun Xia, Youbin Wang, Mengjie Shan, Yan Hao, Zhengyun Liang
Keloids are a fibrotic disease caused by an excessive accumulation of extracellular matrix in the dermis; they have neoplasia-like properties of aggressive growth and high posttreatment recurrence rates. Therefore, it is imperative to gain additional insight into the pathobiology of keloid formation. Single-cell RNA sequencing (scRNA-seq) technology has brought data-driven innovation to understanding
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Targeting neuronal mitophagy in ischemic stroke: an update Burns Trauma (IF 5.3) Pub Date : 2023-06-01 Jun Li, Jiaying Wu, Xinyu Zhou, Yangyang Lu, Yuyang Ge, Xiangnan Zhang
Cerebral ischemia is a neurological disorder associated with complex pathological mechanisms, including autophagic degradation of neuronal mitochondria, or termed mitophagy, following ischemic events. Despite being well-documented, the cellular and molecular mechanisms underlying the regulation of neuronal mitophagy remain unknown. So far, the evidence suggests neuronal autophagy and mitophagy are
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Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway Burns Trauma (IF 5.3) Pub Date : 2023-05-25 Tianyi Chen, Peiyang Song, Min He, Shunli Rui, Xiaodong Duan, Yu Ma, David G Armstrong, Wuquan Deng
Background Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, is enriched in exosomes derived from platelet-rich plasma (PRP-Exos). However, the potential role of PRP-Exos-S1P in diabetic wound healing remains unclear. In this study, we investigated the underlying mechanism of PRP-Exos-S1P in diabetic angiogenesis and wound repair. Methods Exosomes were isolated
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Characterization of cellular senescence in radiation ulcers and therapeutic effects of mesenchymal stem cell-derived conditioned medium. Burns Trauma (IF 5.3) Pub Date : 2023-05-11 Wanchao Chen,Yang Wang,Jiancheng Zheng,Yan Chen,Can Zhang,Wei Yang,Lingling Wu,Zeyu Yang,Yu Wang,Chunmeng Shi
Background Radiation ulcers are a common and severe injury after uncontrolled exposure to ionizing radiation. The most important feature of radiation ulcers is progressive ulceration, which results in the expansion of radiation injury to the nonirradiated area and refractory wounds. Current theories cannot explain the progression of radiation ulcers. Cellular senescence refers to as irreversible growth
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Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease Burns Trauma (IF 5.3) Pub Date : 2023-05-04 Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, Ying Zheng, Richard D Ye, Chris Soon Heng TAN, Yitao Wang, Jia-Hong Lu
Inflammatory bowel disease (IBD) is a chronic, non-specific, recurrent inflammatory disease, majorly affecting the gastrointestinal tract. Due to its unclear pathogenesis, the current therapeutic strategy for IBD is focused on symptoms alleviation. Autophagy is a lysosome-mediated catabolic process for maintaining cellular homeostasis. Genome-wide association studies and subsequent functional studies
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A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial Burns Trauma (IF 5.3) Pub Date : 2023-05-02 Ignace De Decker, Henk Hoeksema, Jozef Verbelen, Petra De Coninck, Marijn Speeckaert, Sofie De Schepper, Phillip Blondeel, Ali Pirayesh, Stan Monstrey, Karel E Y Claes
Background Absence of almost the entire reticular dermal layer is inherent to the use of autologous split-thickness skin grafting (STSG) to close full-thickness wounds, often resulting in hypertrophic scars and contractures. Many dermal substitutes have been developed, but unfortunately most have varying results in terms of cosmetic and/or functional improvement as well as patient satisfaction, in
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Neural grafts containing exosomes derived from Schwann cell-like cells promote peripheral nerve regeneration in rats Burns Trauma (IF 5.3) Pub Date : 2023-04-28 Taotao Hu, Shusen Chang, Fang Qi, Zhonghui Zhang, Jiayin Chen, Lingli Jiang, Dali Wang, Chengliang Deng, Kaiyu Nie, Guangchao Xu, Zairong Wei
Background Schwann cell-like cells (SCLCs), differentiated from mesenchymal stem cells, have shown promising outcomes in the treatment of peripheral nerve injuries in preclinical studies. However, certain clinical obstacles limit their application. Hence, the primary aim of this study was to investigate the role of exosomes derived from SCLCs (SCLCs-exo) in peripheral nerve regeneration. Methods SCLCs
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MicroRNAs in septic acute kidney injury Burns Trauma (IF 5.3) Pub Date : 2023-03-21 Bo Wang, Jun Xu, Ping Fu, Liang Ma
Sepsis is a potentially fatal complication of burns and trauma that can cause acute kidney injury (AKI) with substantial morbidity and mortality, but this disease is poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI remain uncommon. MicroRNAs (miRNAs) are endogenous non-coding RNAs that influence the translation of target messenger RNAs in a variety of biological
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The application of corticosteroids for pathological scar prevention and treatment: current review and update Burns Trauma (IF 5.3) Pub Date : 2023-03-20 Meiying Sheng, Yunsheng Chen, Hua Li, Yixin Zhang, Zheng Zhang
The prevention and treatment of pathological scars remain challenging. Corticosteroids are the mainstay drugs in clinical scar prevention and treatment as they effectively induce scar regression and improve scar pruritus and pain. Currently, intralesional injections of corticosteroids are widely used in clinical practice. These require professional medical manipulation; however, the significant accompanying
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Current understanding of the chronic stress response to burn injury from human studies Burns Trauma (IF 5.3) Pub Date : 2023-03-14 Tyler Osborne, Bradley Wall, Dale W Edgar, Timothy Fairchild, Fiona Wood
There is a marked inflammatory and hypermetabolic response following a burn injury. The interlinked responses are more pronounced than for other forms of trauma and can persist for ≥3 years post-injury in burned patients. After a burn, patients have an increased risk of diseases of ageing including cancer, diabetes and cardiovascular disease, highlighting the need for effective long-term strategies
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Efficacy and safety of extracorporeal membrane oxygenation for burn patients: a comprehensive systematic review and meta-analysis. Burns Trauma (IF 5.3) Pub Date : 2023-03-01 Xue Heng,Peng Cai,Zhiqiang Yuan,Yizhi Peng,Gaoxing Luo,Haisheng Li
Background Respiratory and circulatory dysfunction are common complications and the leading causes of death among burn patients, especially in severe burns and inhalation injury. Recently, extracorporeal membrane oxygenation (ECMO) has been increasingly applied in burn patients. However, current clinical evidence is weak and conflicting. This study aimed to comprehensively evaluate the efficacy and
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Myocardial injury: where inflammation and autophagy meet. Burns Trauma (IF 5.3) Pub Date : 2023-03-01 Chunping Liu,Yanjiao Liu,Huiqi Chen,Xiaofei Yang,Chuanjian Lu,Lei Wang,Jiahong Lu
Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles, aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment. Activation of autophagy can be observed during myocardial injury, during which inflammatory responses are strongly triggered. Autophagy can inhibit the inflammatory response and regulate the inflammatory
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Adjusting the stiffness of a cell-free hydrogel system based on tissue-specific extracellular matrix to optimize adipose tissue regeneration. Burns Trauma (IF 5.3) Pub Date : 2023-03-01 Ye Li,Xin Bi,Mengfan Wu,Xinyao Chen,Weiqing Zhan,Ziqing Dong,Feng Lu
Background Large-area soft tissue defects are challenging to reconstruct. Clinical treatment methods are hampered by problems associated with injury to the donor site and the requirement for multiple surgical procedures. Although the advent of decellularized adipose tissue (DAT) offers a new solution to these problems, optimal tissue regeneration efficiency cannot be achieved because the stiffness
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Nuclear fragile X mental retardation-interacting protein 1-mediated ribophagy protects T lymphocytes against apoptosis in sepsis. Burns Trauma (IF 5.3) Pub Date : 2023-02-28 Peng-Yue Zhao,Ren-Qi Yao,Li-Yu Zheng,Yao Wu,Yu-Xuan Li,Ning Dong,Jing-Yan Li,Xiao-Hui Du,Yong-Ming Yao
Background Ribophagy is a selective autophagic process that specifically degrades dysfunctional or superfluous ribosomes to maintain cellular homeostasis. Whether ribophagy can ameliorate the immunosuppression in sepsis similar to endoplasmic reticulum autophagy (ERphagy) and mitophagy remains unclear. This study was conducted to investigate the activity and regulation of ribophagy in sepsis and to
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Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications. Burns Trauma (IF 5.3) Pub Date : 2023-02-28 Yan Jin,Yixing Song,Jiaqi Lin,Tianqing Liu,Guicai Li,Biqin Lai,Yun Gu,Gang Chen,Lingyan Xing
Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete loss of motor and sensory function. Massive neurons are damaged after the initial mechanical insult. Secondary injuries, which are triggered by immunological and inflammatory responses, also result in neuronal loss and axon retraction. This results in defects in the neural circuit and a deficiency in the
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Melatonin influences the biological characteristics of keloid fibroblasts through the Erk and Smad signalling pathways Burns Trauma (IF 5.3) Pub Date : 2023-02-27 Shaobin Huang, Wuguo Deng, Yunxian Dong, Zhicheng Hu, Yi Zhang, Peng Wang, Xiaoling Cao, Miao Chen, Pu Cheng, Hailin Xu, Wenkai Zhu, Bing Tang, Jiayuan Zhu
Background Keloids are abnormal fibrous hyperplasias that are difficult to treat. Melatonin can be used to inhibit the development of certain fibrotic diseases but has never been used to treat keloids. We aimed to discover the effects and mechanisms of melatonin in keloid fibroblasts (KFs). Methods Flow cytometry, CCK-8 assays, western blotting, wound-healing assays, transwell assays, collagen gel
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Polymeric biomaterials-based tissue engineering for wound healing: a systemic review Burns Trauma (IF 5.3) Pub Date : 2023-02-07 Pratik Das, Suvendu Manna, Shivam Roy, Samit K Nandi, Piyali Basak
Background Biomaterials are vital products used in clinical sectors as alternatives to several biological macromolecules for tissue engineering techniques owing to their numerous beneficial properties, including wound healing. The healing pattern generally depends upon the type of wounds, and restoration of the skin on damaged areas is greatly dependent on the depth and severity of the injury. The
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Pathological changes in the brain after peripheral burns Burns Trauma (IF 5.3) Pub Date : 2023-02-06 Jigang Chen, Danfeng Zhang, Junhui Zhang, Yanni Wang
Brain injuries are common complications in patients with thermal burns and are associated with unpleasant outcomes. In clinical settings, it was once believed that brain injuries were not major pathological processes after burn, at least in part due to the unavailability of specific clinical manifestations. Burn-related brain injuries have been studied for more than a century, but the underlying pathophysiology
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Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing. Burns Trauma (IF 5.3) Pub Date : 2023-02-03 Zhengzhe Han,Lili Deng,Shiyan Chen,Huaping Wang,Yinjun Huang
Background Wound healing is a process that requires angiogenesis and antibacterial activities and it remains a challenge for both experimental and clinical research worldwide. Zn2+ has been reported to be widely involved in angiogenesis and exerts antibacterial effects, making it suitable as a treatment to promote wound healing. Therefore Zn2+-loaded adhesive bacterial cellulose hydrogel was designed
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Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis Burns Trauma (IF 5.3) Pub Date : 2023-01-31 Yunquan Gong, Song Li, Jinghui Wu, Tongyi Zhang, Shunzheng Fang, Daibo Feng, Xiaoqing Luo, Jing Yuan, Yaran Wu, Xiaojing Yan, Yan Zhang, Jun Zhu, Jiangyi Wu, Jiqin Lian, Wei Xiang, Zhenhong Ni
Autophagy, as a fundamental mechanism for cellular homeostasis, is generally involved in the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common musculoskeletal disease that often leads to pain, disability and economic loss in patients. Post-traumatic OA (PTOA) is a subtype of OA, accounting for >12% of the overall burden of OA. PTOA is often caused by joint injuries
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Autophagy in acute kidney injury and maladaptive kidney repair Burns Trauma (IF 5.3) Pub Date : 2023-01-22 Yu Xiang, Ying Fu, Wenwen Wu, Chengyuan Tang, Zheng Dong
Acute kidney injury (AKI) is a major renal disease characterized by a sudden decrease in kidney function. After AKI, the kidney has the ability to repair, but if the initial injury is severe the repair may be incomplete or maladaptive and result in chronic kidney problems. Autophagy is a highly conserved pathway to deliver intracellular contents to lysosomes for degradation. Autophagy plays an important
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Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics Burns Trauma (IF 5.3) Pub Date : 2023-01-21 Kevin H-Y Tsai, Huaikai Shi, Roxanne J Parungao, Sina Naficy, Xiaotong Ding, Xiaofeng Ding, Jonathan J Hew, Xiaosuo Wang, Wojciech Chrzanowski, Gareth G Lavery, Zhe Li, Andrea C Issler-Fisher, Jun Chen, Qian Tan, Peter K Maitz, Mark S Cooper, Yiwei Wang
Background Excessive scarring and fibrosis are the most severe and common complications of burn injury. Prolonged exposure to high levels of glucocorticoids detrimentally impacts on skin, leading to skin thinning and impaired wound healing. Skin can generate active glucocorticoids locally through expression and activity of the 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-HSD1). We hypothesised
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Prospective study and validation of early warning marker discovery based on integrating multi-omics analysis in severe burn patients with sepsis Burns Trauma (IF 5.3) Pub Date : 2023-01-16 Jiamin Huang, Yi Chen, Zaiwen Guo, Yanzhen Yu, Yi Zhang, Pingsong Li, Lei Shi, Guozhong Lv, Bingwei Sun
Background Early detection, timely diagnosis and rapid response are essential for case management and precautions of burn-associated sepsis. However, studies on indicators for early warning and intervention have rarely been conducted. This study was performed to better understand the pathophysiological changes and targets for prevention of severe burn injuries. Methods We conducted a multi-center,
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Glutamine mitigates murine burn sepsis by supporting macrophage M2 polarization through repressing the SIRT5-mediated desuccinylation of pyruvate dehydrogenase. Burns Trauma (IF 5.3) Pub Date : 2022-12-30 Yuanfeng Zhu,Xiaoli Chen,Yongling Lu,Lin Xia,Shijun Fan,Qianying Huang,Xin Liu,Xi Peng
Background Alternative (M2)-activated macrophages drive the anti-inflammatory response against sepsis, a leading cause of death in patients suffering from burn injury. Macrophage M2 polarization is intrinsically linked with dominant oxidative phosphorylation (OXPHOS). Glutamine serves as a major anaplerotic source to fuel OXPHOS, but it remains unknown whether glutamine can modulate metabolic checkpoints
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Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype Burns Trauma (IF 5.3) Pub Date : 2022-12-22 Shiyan Li, Ping Yang, Xiaofeng Ding, Hao Zhang, Youjun Ding, Qian Tan
Background Skin wound healing depends on the progress of different but overlapping stages of healing, including hemostasis, inflammatory, proliferative and remodeling. Failure of these stages to occur in a timely and gradual manner may result in non-healing pathological wounds. Macrophages and neutrophils have been shown to play an essential role in the inflammatory responses of wound tissue, and their
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Robotic systems in total knee arthroplasty: current surgical trauma perspectives. Burns Trauma (IF 5.3) Pub Date : 2022-12-16 Kai Lei,Li-Ming Liu,Lin Guo
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Efficacy and safety of external tissue expansion technique in the treatment of soft tissue defects: a systematic review and meta-analysis of outcomes and complication rates Burns Trauma (IF 5.3) Pub Date : 2022-12-11 Xirui Tong, Jianyu Lu, Wei Zhang, Siqiao Wang, Runzhi Huang, Xianliang Zhang, Jie Huang, Yushu Zhu, Shichu Xiao, Shizhao Ji, Zhaofan Xia
Background Currently, various external tissue expansion devices are becoming widely used. Considering the scarcity of relevant application standards, this systematic review was performed to explore the effectiveness and safety of external tissue expansion techniques for the reconstruction of soft tissue defects. Method A systematic review and meta-analysis on the efficacy and safety of external tissue
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Hydrogels for the management of second-degree burns: currently available options and future promise Burns Trauma (IF 5.3) Pub Date : 2022-12-09 Katherine A Cook, Edith Martinez-Lozano, Robert Sheridan, Edward K Rodriguez, Ara Nazarian, Mark W Grinstaff
Burn wounds result from exposure to hot liquids, chemicals, fire, electric discharge or radiation. Wound severity ranges from first-degree injury, which is superficial, to fourth-degree injury, which exposes bone, tendons and muscles. Rapid assessment of burn depth and accurate wound management in the outpatient setting is critical to prevent injury progression into deeper layers of the dermis. Injury
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HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes Burns Trauma (IF 5.3) Pub Date : 2022-11-24 Chenlu Song, Yiqiu Zhang, Qing Pei, Li Zheng, Meiyu Wang, Youzhen Shi, Shan Wu, Wei Ni, Xiujun Fu, Yinbo Peng, Wen Zhang, Min Yao
Background Sepsis-induced cardiomyopathy (SIC) is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality. Heat shock proteins (HSPs) have been implicated in suppressing septic inflammation. The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction, exuberated inflammation and inflammasome-mediated pyroptosis
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Effects of enteral nutrition with different energy supplies on metabolic changes and organ damage in burned rats Burns Trauma (IF 5.3) Pub Date : 2022-11-22 Yong-Jun Yang, Sen Su, Yong Zhang, Dan Wu, Chao Wang, Yan Wei, Xi Peng
Background Enteral nutrition (EN) is an important treatment for burn patients. However, severe gastrointestinal damage caused by major burns often leads to EN intolerance. Trophic EN solves this problem basically, but how to transition from trophic EN to standard EN smoothly is still a challenge in burn clinical nutrition. The aim of this study is to investigate the effects of EN with different energy
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Neutrophil extracellular traps contribute to myofibroblast differentiation and scar hyperplasia through the Toll-like receptor 9/nuclear factor Kappa-B/interleukin-6 pathway. Burns Trauma (IF 5.3) Pub Date : 2022-11-16 Yiming Shao,Zaiwen Guo,Yunxi Yang,Lu Liu,Jiamin Huang,Yi Chen,Linbin Li,Bingwei Sun
Background Inflammation is an important factor in pathological scarring. The role of neutrophils, one of the most important inflammatory cells, in scar hyperplasia remains unclear. The purpose of this article is to study the correlation between neutrophil extracellular traps (NETs) and scar hyperplasia and identify a new target for inhibiting scar hyperplasia. Methods Neutrophils were isolated from
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MRI tracking of human Wharton's jelly stem cells seeded onto acellular dermal matrix labeled with superparamagnetic iron oxide nanoparticles in burn wounds. Burns Trauma (IF 5.3) Pub Date : 2022-11-11 Davood Mehrabani,Mehra Nazempour,Rouhollah Mehdinavaz-Aghdam,Seyedeh-Sara Hashemi,Reza Jalli,Mahdi Saeedi Moghadam,Shahrokh Zare,Iman Jamhiri,Javad Moayedi,Feridoun Karimi-Busheri
Background In vivo cell tracking after transplantation in regenerative medicine remains an unmet challenge and limits current understanding of the wound healing mechanism through cell-based therapies. This study investigated tracking of human Wharton's jelly stem cells (hWJSCs) seeded onto an acellular dermal matrix (ADM) and labeled with superparamagnetic iron oxide nanoparticles (SPIONs) by magnetic
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Skin cell-derived extracellular vesicles: a promising therapeutic strategy for cutaneous injury. Burns Trauma (IF 5.3) Pub Date : 2022-10-18 Min Wang,Peipei Wu,Jin Huang,Wenhui Liu,Hui Qian,Yaoxiang Sun,Hui Shi
Wound healing refers to the healing process that occurs after the skin and other tissues are separated or damaged by internal or external forces. It is a complex combination of tissue regeneration, granulation tissue hyperplasia, and scar formation, and shows the synergistic effects of these processes. After skin damage, the environment around the wound and the cells at site of the damage respond immediately
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P311 promotes type II transforming growth factor-β receptor mediated fibroblast activation and granulation tissue formation in wound healing Burns Trauma (IF 5.3) Pub Date : 2022-10-14 Jue Wang, Ruoyu Shang, Jiacai Yang, Zhihui Liu, Yunxia Chen, Cheng Chen, Wenxia Zheng, Yuanyang Tang, Xiaorong Zhang, Xiaohong Hu, Yong Huang, Han-Ming Shen, Gaoxing Luo, Weifeng He
Background P311, a highly conserved 8 kDa intracellular protein, has recently been reported to play an important role in aggravating hypertrophic scaring by promoting the differentiation and secretion of fibroblasts. Nevertheless, how P311 regulates the differentiation and function of fibroblasts to affect granulation tissue formation remains unclear. In this work, we studied the underlying mechanisms