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The role of Q10 engineering mesenchymal stem cell-derived exosomes in inhibiting ferroptosis for diabetic wound healing Burns Trauma (IF 6.3) Pub Date : 2024-11-27 Ronghua Yang, Sitong Zhou, Jie Huang, Deni Kang, Yao Chen, Xinyi Wang, Yan Shi, Zhengguang Wang
Background Ferroptosis plays an essential role in the development of diabetes and its complications, suggesting its potential as a therapeutic target. Stem cell-derived extracellular vesicles (EVs) are increasingly being developed as nano-scale drug carriers. The aim of this study was to determine the role of ferroptosis in the pathogenesis of diabetic wound healing and evaluate the therapeutic effects
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Dexmedetomidine regulates exosomal miR-29b-3p from macrophages and alleviates septic myocardial injury by promoting autophagy in cardiomyocytes via targeting glycogen synthase kinase 3β Burns Trauma (IF 6.3) Pub Date : 2024-11-05 Tianyi Yu, Hsinying Liu, Min Gao, Dan Liu, JiaQiang Wang, Jie Zhang, Jizhuang Wang, Peilang Yang, Xiong Zhang, Yan Liu
Background Our previous research suggested that dexmedetomidine (Dex) promotes autophagy in cardiomyocytes, thus safeguarding them against apoptosis during sepsis. However, the underlying mechanisms of Dex-regulated autophagy have remained elusive. This study aimed to explore the role of exosomes and how they participate in Dex-induced cardioprotection in sepsis. The underlying microRNA (miRNA) mechanisms
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SportSync health: revolutionizing patient care in sports medicine through integrated follow-up technologies. Burns Trauma (IF 6.3) Pub Date : 2024-11-04 Zhiwen Luo,Chen Chen,Quan Gan,Renwen Wan,Zhenghua Hong,Min Zhu,Xiaohan Wu,Linlin Sha,Yisheng Chen,Yanwei He,Xingting Feng,Junbo Liang,Shiyi Chen,Xiaobo Zhou
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Polylactic acid-based dressing with oxygen generation and enzyme-like activity for accelerating both light-driven biofilm elimination and wound healing Burns Trauma (IF 6.3) Pub Date : 2024-10-25 Tianci Wen, Shilang Xiong, Huihui Zhao, Junzhe Wang, Chunming Wang, Zhisheng Long, Long Xiong, Guowen Qian
Background Photodynamic therapy (PDT) is a widely used therapeutic approach for eradicating bacterial biofilms in infected wound, but its effectiveness is limited by the hypoxic environment within the biofilm. This study aimed to investigate whether the efficiency of photodynamic removing biofilm is improving by providing oxygen (O2), as well as the expression of cytokines involved in infected wound
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Consensus on the prevention and repair of titanium mesh exposed wound after cranioplasty (2024 edition). Burns Trauma (IF 6.3) Pub Date : 2024-10-23 Pihong Zhang,Xiaobing Fu,Yuesheng Huang,
Titanium mesh exposure after cranioplasty is the most serious complication of this procedure. Although some clinical experience has been gradually accumulated over the years in the diagnosis and treatment of titanium mesh exposure, the treatment is often not standardized and it is difficult to achieve satisfactory repair results due to insufficient understanding of its pathogenesis and concurrent infections
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Single-cell sequencing technology in skin wound healing Burns Trauma (IF 6.3) Pub Date : 2024-10-23 Xu Cheng Cheng, Wang Zi Tong, Wang Rui, Zhao Feng, Hou Shuai, Wang Zhe
Skin wound healing is a complicated biological process that mainly occurs in response to injury, burns, or diabetic ulcers. It can also be triggered by other conditions such as dermatitis and melanoma-induced skin cancer. Delayed healing or non-healing after skin injury presents an important clinical issue; therefore, further explorations into the occurrence and development of wound healing at the
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Engineered extracellular vesicles for tissue repair and regeneration. Burns Trauma (IF 6.3) Pub Date : 2024-10-22 Yan Zhang,Dan Wu,Chen Zhou,Muran Bai,Yucheng Wan,Qing Zheng,Zhijin Fan,Xianwen Wang,Chun Yang
Extracellular vesicles (EVs) are heterogeneous membrane-like vesicles secreted by living cells that are involved in many physiological and pathological processes and act as intermediaries of intercellular communication and molecular transfer. Recent studies have shown that EVs from specific sources regulate tissue repair and regeneration by delivering proteins, lipids, and nucleic acids to target cells
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Suture-anchored cutaneous tension induces persistent hypertrophic scarring in a novel murine model Burns Trauma (IF 6.3) Pub Date : 2024-10-21 Yashu Li, Anqi Liu, Jingyan Wang, Changsheng Yang, Kaiyang Lv, Weifeng He, Jun Wu, Wenbin Chen
Background Hypertrophic scars cause impaired skin appearance and function, seriously affecting physical and mental health. Due to medical ethics and clinical accessibility, the collection of human scar specimens is frequently restricted, and the establishment of scar experimental animal models for scientific research is urgently needed. The four most commonly used animal models of hypertrophic scars
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Mechanical stimulation promotes fibrochondrocyte proliferation by activating the TRPV4 signaling pathway during tendon–bone insertion healing: CCN2 plays an important regulatory role Burns Trauma (IF 6.3) Pub Date : 2024-10-20 Xuting Bian, Xiao Liu, Mei Zhou, Hong Tang, Rui Wang, Lin Ma, Gang He, Shibo Xu, Yunjiao Wang, Jindong Tan, Kanglai Tang, Lin Guo
Background We previously confirmed that mechanical stimulation is an important factor in the repair of tendon–bone insertion (TBI) injuries and that mechanoreceptors such as transient receptor potential ion-channel subfamily V member 4 (TRPV4; also known as transient receptor potential vanilloid 4) are key to transforming mechanical stimulation into intracellular biochemical signals. This study aims
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Twist-related protein 1 promotes transforming growth factor β receptor 1 in keloid fibroblasts via regulating the stability of myocyte enhancer factor 2A Burns Trauma (IF 6.3) Pub Date : 2024-10-19 Tianhao Li, Mingzi Zhang, Yunzhu Li, Yixin Sun, Jiuzuo Huang, Ang Zeng, Nanze Yu, Xiao Long
Background Keloid scarring is caused by a fibroproliferative disorder due to abnormal activation of genes, the underlying mechanism of which is still unclear. The basic helix–loop–helix transcription factor Twist-related protein 1 (TWIST1) controls cell proliferation and differentiation in tissue development and disease processes. In this study, we aimed to clarify the essential role of TWIST1 in the
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Silk fibroin–gelatine haemostatic sponge loaded with thrombin for wound haemostasis and tissue regeneration Burns Trauma (IF 6.3) Pub Date : 2024-10-14 Yajun Zhang, Ming Li, Jing Chang, Chang Li, Yuwen Hui, Yanhua Wang, Weiguo Xu
Background Wound haemostasis is an important part of clinical treatments, especially treatments for patients with avulsion injury, destructive injury and large-scale soft tissue injury. Therefore, developing fast and effective haemostatic materials is critical. This study aimed to design a novel and efficient silk fibroin–gelatine composite haemostatic sponge loaded with thrombin (SFG@TB) to assist
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Beta blockers in critical illness: promising but appropriate subphenotyping is needed. Burns Trauma (IF 6.3) Pub Date : 2024-09-30 Luyao Zhang,Lu Ke
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Mechanical strategies to promote vascularization for tissue engineering and regenerative medicine. Burns Trauma (IF 6.3) Pub Date : 2024-09-30 Yiran Wang,Meixuan Liu,Wei Zhang,Huan Liu,Fang Jin,Shulei Mao,Chunmao Han,Xingang Wang
Vascularization is a major challenge in the field of tissue engineering and regenerative medicine. Mechanical factors have been demonstrated to play a fundamental role in vasculogenesis and angiogenesis and can affect the architecture of the generated vascular network. Through the regulation of mechanical factors in engineered tissues, various mechanical strategies can be used to optimize the preformed
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Lymphangiogenesis: novel strategies to promote cutaneous wound healing Burns Trauma (IF 6.3) Pub Date : 2024-09-27 Yang Jian, Yanqi Li, Yanji Zhang, Mingyuan Tang, Mingfu Deng, Chenxiaoxiao Liu, Maolin Cheng, Shune Xiao, Chengliang Deng, Zairong Wei
The cutaneous lymphatic system regulates tissue inflammation, fluid balance and immunological responses. Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema, immune deficiency, chronic inflammation etc. Tissue regeneration and healing depend on angiogenesis and lymphangiogenesis during wound healing. Tissue oedema and chronic inflammation can slow wound healing due to impaired lymphangiogenesis
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Glutamine promotes the proliferation of intestinal stem cells via inhibition of TP53-induced glycolysis and apoptosis regulator promoter methylation in burned mice Burns Trauma (IF 6.3) Pub Date : 2024-09-27 Panyang Zhang, Dan Wu, Xule Zha, Sen Su, Yajuan Zhang, Yan Wei, Lin Xia, Shijun Fan, Xi Peng
Background Intestinal stem cells (ISCs) play a pivotal role in maintaining intestinal homeostasis and facilitating the restoration of intestinal mucosal barrier integrity. Glutamine (Gln) is a crucial energy substrate in the intestine, promoting the proliferation of ISCs and mitigating damage to the intestinal mucosal barrier after burn injury. However, the underlying mechanism has not yet been fully
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The pharmacological landscape of chronic subdural hematoma: a systematic review and network meta-analysis of randomized and non-randomized controlled studies. Burns Trauma (IF 6.3) Pub Date : 2024-09-26 Tao Liu,Zhihao Zhao,Mingqi Liu,Shuo An,Meng Nie,Xuanhui Liu,Yu Qian,Ye Tian,Jianning Zhang,Rongcai Jiang
Background There are various treatment modalities for chronic subdural hematoma (CSDH) and there is extensive debate surrounding pharmaceutical interventions. There is no consensus regarding the relative efficacy and safety of multiple treatment modalities. This study aims to investigate this issue and offer potential clinical recommendations. Methods We searched PubMed, Web of Science, Embase and
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Thermo-responsive cascade antimicrobial platform for precise biofilm removal and enhanced wound healing Burns Trauma (IF 6.3) Pub Date : 2024-09-25 Ting Du, Jiangli Cao, Zhannuo Zhang, Zehui Xiao, Jingbo Jiao, Zhiyong Song, Xinjun Du, Shuo Wang
Background Bacterial infection, tissue hypoxia and inflammatory response can hinder infected wound repair. This study aimed to develop a multifunctional specific therapeutic photo-activated release nanosystem [HMPB@MB@AuNPs@PMB@HA (HMAPH)] by loading photosensitizer methylene blue (MB) into hollow mesoporous Prussian blue nanostructures and modifying the surface with gold particles, polymyxin B (PMB)
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Developing a calculable risk prediction model for sternal wound infection after median sternotomy: a retrospective study Burns Trauma (IF 6.3) Pub Date : 2024-09-14 Yang Chen, Fei He, Fan Wu, Xiaolong Hu, Wanfu Zhang, Shaohui Li, Hao Zhang, Weixun Duan, Hao Guan
Background Diagnosing sternal wound infection (SWI) following median sternotomy remains laborious and troublesome, resulting in high mortality rates and great harm to patients. Early intervention and prevention are critical and challenging. This study aimed to develop a simple risk prediction model to identify high-risk populations of SWI and to guide examination programs and intervention strategies
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Reshaped commensal wound microbiome via topical application of Calvatia gigantea extract contributes to faster diabetic wound healing. Burns Trauma (IF 6.3) Pub Date : 2024-09-02 Xiaotong Ding,Chenxi Yang,Yue Li,Tangtang He,Yan Xu,Xuxi Cheng,Jinyun Song,Nannan Xue,Wen Min,Weimeng Feng,Hongyu Zhao,Jie Dong,Pei Liu,Yiwei Wang,Jun Chen
Background Calvatia gigantea (CG) is widely used as a traditional Chinese medicine for wound treatment. In this study, we aimed to determine the effects of CG extract (CGE) on diabetic wound healing and the commensal wound microbiome. Method A wound model was established using leptin receptor-deficient db/db mice, with untreated mice as the control group and CGE-treated mice as the treatment group
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BRD3308 suppresses macrophage oxidative stress and pyroptosis via upregulating acetylation of H3K27 in sepsis-induced acute lung injury. Burns Trauma (IF 6.3) Pub Date : 2024-09-02 Bohao Liu,Ning Li,Yi Liu,Yan Zhang,Limei Qu,Hongfei Cai,Yang Li,Xiaojing Wu,Qing Geng
Background Sepsis-induced acute lung injury (ALI) leads to severe hypoxemia and respiratory failure, contributing to poor prognosis in septic patients. Endotoxin dissemination triggers oxidative stress and the release of inflammatory cytokines in macrophages, initiating diffuse alveolar damage. The role of epigenetic histone modifications in organ injury is increasingly recognized. The present study
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Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights. Burns Trauma (IF 6.3) Pub Date : 2024-08-13 Arshia Fakouri,Zahra-Sadat Razavi,Adil Tawfeeq Mohammed,Abbas Hameed Abdul Hussein,Hamed Afkhami,Mohammad Hosseini Hooshiar
The healing process at a wound is made up of many types of cells, growth factors, the extracellular matrix, nerves and blood vessels all interacting with each other in complex and changing ways. Microbial colonization and proliferation are possible at the place of injury, which makes infection more likely. Because of this, any cut has a chance of getting an infection. Researchers have found that wound
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Adipose stem cell-derived exosomes in the treatment of wound healing in preclinical animal models: a meta-analysis Burns Trauma (IF 6.3) Pub Date : 2024-08-04 Jing-tao Wei, Ting He, Kuo Shen, Zhi-gang Xu, Jun-tao Han, Xue-kang Yang
Background Wound healing has always been a serious issue for doctors and primary health care systems. In addition, adipose stem cell-derived exosomes have been proven to play a positive and effective role in tissue repair and regeneration. A systematic review of these preclinical studies was performed to assess the efficacy of adipose stem cell-derived exosomes (ADSC-Exos) in treating wounds. This
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Intraoperative hypotension associated with postoperative acute kidney injury in hypertension patients undergoing non-cardiac surgery: a retrospective cohort study Burns Trauma (IF 6.3) Pub Date : 2024-07-25 Jin Li, Yeshuo Ma, Yang Li, Wen Ouyang, Zongdao Liu, Xing Liu, Bo Li, Jie Xiao, Daqing Ma, Yongzhong Tang
Background Acute kidney injury (AKI) is a common surgical complication and is associated with intraoperative hypotension. However, the total duration and magnitude of intraoperative hypotension associated with AKI remains unknown. In this study, the causal relationship between the intraoperative arterial pressure and postoperative AKI was investigated among chronic hypertension patients undergoing
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Early protein delivery in critically ill patients with acute kidney injury: post hoc analysis of a multicenter cluster-randomized controlled trial. Burns Trauma (IF 6.3) Pub Date : 2024-07-24 Cheng Lv,Lingliang Zhou,Yufeng Zhou,Charles Chin Han Lew,Zheng-Yii Lee,M Shahnaz Hasan,Baiqiang Li,Yang Liu,Jiajia Lin,Wenjian Mao,Christian Stoppe,Arthur Raymond Hubert van Zanten,Weiqin Li,Yuxiu Liu,Lu Ke,
Background There is controversy over the optimal early protein delivery in critically ill patients with acute kidney injury (AKI). This study aims to evaluate whether the association between early protein delivery and 28-day mortality was impacted by the presence of AKI in critically ill patients. Methods This is a post hoc analysis of data from a multicenter cluster-randomised controlled trial enrolling
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Identification of the optimal predictive cutoff value for expanded flap viability using indocyanine green angiography: a prospective study. Burns Trauma (IF 6.3) Pub Date : 2024-07-18 Shuchen Gu,Yimin Khoong,Yashan Gao,Haizhou Li,Bin Gu,Feng Xie,Xin Huang,Tao Zan
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Engineered exosomes as a prospective therapy for diabetic foot ulcers Burns Trauma (IF 6.3) Pub Date : 2024-07-18 Lifei Guo, Dan Xiao, Helin Xing, Guodong Yang, Xuekang Yang
Diabetic foot ulcer (DFU), characterized by high recurrence rate, amputations and mortality, poses a significant challenge in diabetes management. The complex pathology involves dysregulated glucose homeostasis leading to systemic and local microenvironmental complications, including peripheral neuropathy, micro- and macro-angiopathy, recurrent infection, persistent inflammation and dysregulated re-epithelialization
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Integrins as a bridge between bacteria and cells: key targets for therapeutic wound healing Burns Trauma (IF 6.3) Pub Date : 2024-07-16 Dong Yu, Zhaoyu Lu, Yang Chong
Integrins are heterodimers composed of α and β subunits that are bonded through non-covalent interactions. Integrins mediate the dynamic connection between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins are present in various tissues and organs where these heterodimers participate in diverse physiological and pathological responses at the molecular level in living
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Bioengineered mesenchymal stem cell-derived exosomes: emerging strategies for diabetic wound healing Burns Trauma (IF 6.3) Pub Date : 2024-07-16 Lihua Liu, Dewu Liu
Diabetic wounds are among the most common complications of diabetes mellitus and their healing process can be delayed due to persistent inflammatory reactions, bacterial infections, damaged vascularization and impaired cell proliferation, which casts a blight on patients’health and quality of life. Therefore, new strategies to accelerate diabetic wound healing are being positively explored. Exosomes
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Computed tomography angiography-guided precise flap surgery: a new strategy for flap selection, mapping and harvesting. Burns Trauma (IF 6.3) Pub Date : 2024-07-02 Yan Shi,Yongyue Su,Xi Yang,Jiazhang Duan,Xiaoqing He
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From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration Burns Trauma (IF 6.3) Pub Date : 2024-07-02 Yifan Wu, Junwu Zou, Kai Tang, Ying Xia, Xixi Wang, Lili Song, Jinhai Wang, Kai Wang, Zhihong Wang
The unique ability of piezoelectric materials to generate electricity spontaneously has attracted widespread interest in the medical field. In addition to the ability to convert mechanical stress into electrical energy, piezoelectric materials offer the advantages of high sensitivity, stability, accuracy and low power consumption. Because of these characteristics, they are widely applied in devices
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The NLRP3 inflammasome in burns: a novel potential therapeutic target Burns Trauma (IF 6.3) Pub Date : 2024-07-02 Haihong Li, Junhong Zhao, Leilei Cao, Qizhi Luo, Cuiping Zhang, Lei Zhang
Burns are an underestimated serious injury negatively impacting survivors physically, psychologically and economically, and thus are a considerable public health burden. Despite significant advancements in burn treatment, many burns still do not heal or develop serious complications/sequelae. The nucleotide-binding oligomerization domain-like receptors (NLRs) family pyrin domain-containing 3 (NLRP3)
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Engineered nanovesicles from activated neutrophils with enriched bactericidal proteins have molecular debridement ability and promote infectious wound healing Burns Trauma (IF 6.3) Pub Date : 2024-06-20 Hangfei Jin, Xiao Wen, Ran Sun, Yanzhen Yu, Zaiwen Guo, Yunxi Yang, Linbin Li, Bingwei Sun
Background Bacterial infections pose a considerable threat to skin wounds, particularly in the case of challenging-to-treat diabetic wounds. Systemic antibiotics often struggle to penetrate deep wound tissues and topically applied antibiotics may lead to sensitization, necessitating the development of novel approaches for effectively treating germs in deep wound tissues. Neutrophils, the predominant
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Pre-expanded muscle-sparing latissimus dorsi flap in defect reconstruction and its application strategy. Burns Trauma (IF 6.3) Pub Date : 2024-06-19 Yashan Gao,En Yang,Shenying Luo,Xin Huang,Yi Min Khoong,Shuchen Gu,Yunhan Liu,Wenzheng Xia,Haizhou Li,Tao Zan
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Early short-term hypoxia promotes epidermal cell migration by activating the CCL2-ERK1/2 pathway and epithelial-mesenchymal transition during wound healing. Burns Trauma (IF 6.3) Pub Date : 2024-06-17 Linbo Jin,Shiqi Zhou,Shihan Zhao,Junhui Long,Zhidan Huang,Junli Zhou,Yiming Zhang
Background Due to vasculature injury and increased oxygen consumption, the early wound microenvironment is typically in a hypoxic state. We observed enhanced cell migration ability under early short-term hypoxia. CCL2 belongs to the CC chemokine family and was found to be increased in early hypoxic wounds and enriched in the extracellular signal-regulated kinase (ERK)1/2 pathway in our previous study
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Serial platelet count as a dynamic prediction marker of hospital mortality among septic patients Burns Trauma (IF 6.3) Pub Date : 2024-06-16 Qian Ye, Xuan Wang, Xiaoshuang Xu, Jiajin Chen, David C Christiani, Feng Chen, Ruyang Zhang, Yongyue Wei
Background Platelets play a critical role in hemostasis and inflammatory diseases. Low platelet count and activity have been reported to be associated with unfavorable prognosis. This study aims to explore the relationship between dynamics in platelet count and in-hospital morality among septic patients and to provide real-time updates on mortality risk to achieve dynamic prediction. Methods We conducted
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Hypoxic environment of wounds and photosynthesis-based oxygen therapy Burns Trauma (IF 6.3) Pub Date : 2024-06-10 Shuning Tian, Shenyu Tan, Mingjie Fan, Wenlin Gong, Tianchang Yang, Fangwen Jiao, Hongzhi Qiao
The hypoxic environment is among the most important factors that complicates the healing of chronic wounds, such as venous leg ulcers, pressure injuries and diabetic foot ulcers, which seriously affects the quality of life of patients. Various oxygen supply treatments are used in clinical practice to improve the hypoxic environment at the wound site. However, problems still occur, such as insufficient
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Neuregulin-1, a member of the epidermal growth factor family, mitigates STING-mediated pyroptosis and necroptosis in ischaemic flaps Burns Trauma (IF 6.3) Pub Date : 2024-06-10 Xuwei Zhu, Gaoxiang Yu, Ya Lv, Ningning Yang, Yinuo Zhao, Feida Li, Jiayi Zhao, Zhuliu Chen, Yingying Lai, Liang Chen, Xiangyang Wang, Jian Xiao, Yuepiao Cai, Yongzeng Feng, Jian Ding, Weiyang Gao, Kailiang Zhou, Hui Xu
Background Ensuring the survival of the distal end of a random flap during hypoperfusion (ischaemia) is difficult in clinical practice. Effective prevention of programmed cell death is a potential strategy for inhibiting ischaemic flap necrosis. The activation of stimulator of interferon genes (STING) pathway promotes inflammation and leads to cell death. The epidermal growth factor family member neuregulin-1
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Structure-optimized and microenvironment-inspired nanocomposite biomaterials in bone tissue engineering Burns Trauma (IF 6.3) Pub Date : 2024-06-10 Zheng Lv, Ying Ji, Guoliang Wen, Xiayi Liang, Kun Zhang, Wei Zhang
Critical-sized bone defects represent a significant clinical challenge due to their inability to undergo spontaneous regeneration, necessitating graft interventions for effective treatment. The development of tissue-engineered scaffolds and regenerative medicine has made bone tissue engineering a highly viable treatment for bone defects. The physical and biological properties of nanocomposite biomaterials
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Immunomodulatory poly(L-lactic acid) nanofibrous membranes promote diabetic wound healing by inhibiting inflammation, oxidation and bacterial infection. Burns Trauma (IF 6.3) Pub Date : 2024-06-05 Yan Wu,Jin Zhang,Anqi Lin,Tinglin Zhang,Yong Liu,Chunlei Zhang,Yongkui Yin,Ran Guo,Jie Gao,Yulin Li,Yanhui Chu
Background Given the significant impact on human health, it is imperative to develop novel treatment approaches for diabetic wounds, which are prevalent and serious complications of diabetes. The diabetic wound microenvironment has a high level of reactive oxygen species (ROS) and an imbalance between proinflammatory and anti-inflammatory cells/factors, which hamper the healing of chronic wounds. This
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Extracellular cold-inducible RNA-binding protein mediated neuroinflammation and neuronal apoptosis after traumatic brain injury Burns Trauma (IF 6.3) Pub Date : 2024-05-30 Yu-xiao Liu, Ming Zhao, Yang Yu, Jing-peng Liu, Wen-jia Liu, Ren-qi Yao, Jing Wang, Rong-li Yang, Yao Wu, Ning Dong, Yang Cao, Shou-chun Li, Qin-hong Zhang, Run-min Yan, Yong-ming Yao
Background Extracellular cold-inducible RNA-binding protein (eCIRP) plays a vital role in the inflammatory response during cerebral ischaemia. However, the potential role and regulatory mechanism of eCIRP in traumatic brain injury (TBI) remain unclear. Here, we explored the effect of eCIRP on the development of TBI using a neural-specific CIRP knockout (KO) mouse model to determine the contribution
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Acidic fibroblast growth factor inhibits reactive oxygen species-induced epithelial–mesenchymal transdifferentiation in vascular endothelial cells via the miR-155-5p/SIRT1/Nrf2/HO-1 pathway to promote wound healing in diabetic mice Burns Trauma (IF 6.3) Pub Date : 2024-05-27 Yue Zhang, Fenghui Hei, Yujie Xiao, Yang Liu, Juntao Han, Dahai Hu, Hongtao Wang
Background Diabetic chronic wounds are among the most common and serious complications of diabetes and are associated with significant morbidity and mortality. Endothelial-to-mesenchymal transition (EndMT) is a specific pathological state in which endothelial cells are transformed into mesenchymal cells in response to various stimuli, such as high glucose levels and high oxidative stress. Acidic fibroblast
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miR-125b-5p delivered by adipose-derived stem cell exosomes alleviates hypertrophic scarring by suppressing Smad2. Burns Trauma (IF 6.3) Pub Date : 2024-05-18 Chaolei Xu,Hao Zhang,Chen Yang,Ying Wang,Kejia Wang,Rui Wang,Wei Zhang,Chao Li,Chenyang Tian,Chao Han,Mengyang Li,Xu Liu,Yunwei Wang,Yan Li,Jian Zhang,Yu Li,Liang Luo,Yage Shang,Lixia Zhang,Yuxi Chen,Kuo Shen,Dahai Hu
Background Hypertrophic scarring is the most serious and unmet challenge following burn and trauma injury and often leads to pain, itching and even loss of function. However, the demand for ideal scar prevention and treatment is difficult to satisfy. We aimed to discover the effects and mechanisms of adipose-derived stem cell (ADSC) exosomes in hypertrophic scarring. Methods ADSC exosomes were isolated
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1H-nuclear magnetic resonance analysis reveals dynamic changes in the metabolic profile of patients with severe burns Burns Trauma (IF 6.3) Pub Date : 2024-05-16 Sen Su, Yong Zhang, Dan Wu, Chao Wang, Jianhong Hu, Yan Wei, Xi Peng
Background Severe burn injury causes a hypermetabolic response, resulting in muscle protein catabolism and multiple organ damage syndrome. However, this response has not yet been continuously characterized by metabolomics in patients. This study aims to quantify temporal changes in the metabolic processes of patients with severe burns. Methods We employed 1H-nuclear magnetic resonance (NMR) spectroscopy
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Exosome-mimetic vesicles derived from fibroblasts carrying matrine for wound healing Burns Trauma (IF 6.3) Pub Date : 2024-05-15 Xinyue Zhang, Jiahua Huang, Jing Zhao, Lisha Li, Fengze Miao, Tingrui Zhang, Zhongjian Chen, Xing Zhou, Zongguang Tai, Quangang Zhu
Background Chronic skin wounds are a leading cause of hospital admissions and reduced life expectancy among older people and individuals with diabetes. Delayed wound healing is often attributed to a series of cellular abnormalities. Matrine, a well-studied component found in Sophora flavescens, is recognized for its anti-inflammatory effects. However, its impact on wound healing still remains uncertain
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Clinical application of digital technology in the use of anterolateral thigh lobulated perforator flaps to repair complex soft tissue defects of the limbs Burns Trauma (IF 6.3) Pub Date : 2024-05-11 Kai-xuan Dong, Ya Zhou, Yao-yu Cheng, Hao-tian Luo, Jia-zhang Duan, Xi Yang, Yong-qing Xu, Sheng Lu, Xiao-qing He
Background It is challenging to repair wide or irregular defects with traditional skin flaps, and anterolateral thigh (ALT) lobulated perforator flaps are an ideal choice for such defects. However, there are many variations in perforators, so good preoperative planning is very important. This study attempted to explore the feasibility and clinical effect of digital technology in the use of ALT lobulated
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Genetic polymorphisms, biomarkers and signaling pathways associated with septic shock: from diagnosis to therapeutic targets Burns Trauma (IF 6.3) Pub Date : 2024-05-07 Mingzheng Wu, Bobin Mi, Liu Liu, Haoli Ma, Cheng Jiang, Shan Jiang, Yulin Li, Yan Zhao
Septic shock is a severe form of sepsis characterized by high global mortality rates and significant heritability. Clinicians have long been perplexed by the differential expression of genes, which poses challenges for early diagnosis and prompt treatment of septic shock. Genetic polymorphisms play crucial roles in determining susceptibility to, mortality from, and the prognosis of septic shock. Research
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Effects of early exercise training following severe burn injury: a randomized controlled trial Burns Trauma (IF 6.3) Pub Date : 2024-05-07 David R Schieffelers, Tianfeng Ru, Haonan Dai, Ziqing Ye, Eric van Breda, Ulrike Van Daele, Weiguo Xie, Jun Wu
Background Despite being a stable component of burn rehabilitation at later stages of recovery, exercise training is not commonly provided during the acute phase of burns. A lack of evidence surrounding its efficacy and safety in severely burned adults has hampered its implementation in acute burn care. The aim of this study was to investigate the capacity of early exercise training to modulate parameters
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Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway Burns Trauma (IF 6.3) Pub Date : 2024-05-05 Lanjuan Xu, Tingting An, Baohui Jia, Qiong Wu, Jinggui Shen, Jie Jin, Jing Liu, Chengjian Li
Background Oxidative stress (OS) and inflammatory reactions play pivotal roles in secondary brain injury after traumatic brain injury (TBI). Histone deacetylase 3 (HDAC3) controls the acetylation of histones and non-histones, which has a significant impact on the central nervous system’s reaction to damage. This research determined the implications of RGFP966, a new and specific inhibitor of HDAC3
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Sebaceous gland organoid engineering Burns Trauma (IF 6.3) Pub Date : 2024-05-02 Yiqiong Liu, Huanhuan Gao, Huating Chen, Shuaifei Ji, Lu Wu, Hongliang Zhang, Yujia Wang, Xiaobing Fu, Xiaoyan Sun
Sebaceous glands (SGs), as holocrine-secreting appendages, lubricate the skin and play a central role in the skin barrier. Large full-thickness skin defects cause overall architecture disruption and SG loss. However, an effective strategy for SG regeneration is lacking. Organoids are 3D multicellular structures that replicate key anatomical and functional characteristics of in vivo tissues and exhibit
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Administration and effects of beta blockers and oxandrolone in severely burned adults: a post hoc analysis of the RE-ENERGIZE trial Burns Trauma (IF 6.3) Pub Date : 2024-04-22 Gabriel Hundeshagen, Elisabeth Blears, Viktoria Mertin, Andrew G Day, Alen Palackic, Christian Tapking, Valentin Haug, Ulrich Kneser, Björn Bliesener, Adriana C Panayi, Ariel Aballay, Francois Depret, Christian Stoppe, Daren K Heyland
Background Prospective randomized trials in severely burned children have shown the positive effects of oxandrolone (OX), beta blockers (BB) and a combination of the two (BBOX) on hypermetabolism, catabolism and hyperinflammation short- and long-term post-burn. Although data on severely burned adults are lacking in comparison, BB, OX and BBOX appear to be commonly employed in this patient population
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Propofol and salvianolic acid A synergistically attenuated cardiac ischemia-reperfusion injury in diabetic mice via modulating the CD36/AMPK pathway. Burns Trauma (IF 6.3) Pub Date : 2024-04-09 Jiaqi Zhou,Weiyi Xia,Jiajia Chen,Kaijia Han,Yuxin Jiang,Anyuan Zhang,Dongcheng Zhou,Danyong Liu,Jiefu Lin,Yin Cai,Guanghua Chen,Liangqing Zhang,Aimin Xu,Youhua Xu,Ronghui Han,Zhengyuan Xia
Background Prevention of diabetic heart myocardial ischemia-reperfusion (IR) injury (MIRI) is challenging. Propofol attenuates MIRI through its reactive oxygen species scavenging property at high doses, while its use at high doses causes hemodynamic instability. Salvianolic acid A (SAA) is a potent antioxidant that confers protection against MIRI. Both propofol and SAA affect metabolic profiles through
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Development of 3D printed electrospun vascular graft loaded with tetramethylpyrazine for reducing thrombosis and restraining aneurysmal dilatation. Burns Trauma (IF 6.3) Pub Date : 2024-04-08 Yihong Shen,Yanjun Pan,Fubang Liang,Jiahui Song,Xiao Yu,Jie Cui,Guangfang Cai,Mohamed El-Newehy,Meera Moydeen Abdulhameed,Hongbing Gu,Binbin Sun,Meng Yin,Xiumei Mo
Background Small-diameter vascular grafts have become the focus of attention in tissue engineering. Thrombosis and aneurysmal dilatation are the two major complications of the loss of vascular access after surgery. Therefore, we focused on fabricating 3D printed electrospun vascular grafts loaded with tetramethylpyrazine (TMP) to overcome these limitations. Methods Based on electrospinning and 3D printing
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Novel strategies in scalp expansion: improvements and applications of tissue expanders. Burns Trauma (IF 6.3) Pub Date : 2024-04-08 Fangzhou Xie,Jiaqi Qin,Bin Fang,Shuangbai Zhou,Ru-Lin Huang,Qingfeng Li,Rao Fu,Yun Xie
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Acne-induced pathological scars: pathophysiology and current treatments Burns Trauma (IF 6.3) Pub Date : 2024-04-06 Wanyu Xu, Dorsa Gholamali Sinaki, Yuchen Tang, Yunsheng Chen, Yixin Zhang, Zheng Zhang
Acne is a common chronic inflammatory dermatosis that can lead to pathological scars (PSs, divided into hypertrophic scars and keloids). These kinds of abnormal scars seriously reduce the quality of life of patients. However, their mechanism is still unclear, resulting in difficult clinical prevention, unstable treatment effects and a high risk of recurrence. Available evidence supports inflammatory
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Nocardia rubra cell-wall skeleton mitigates whole abdominal irradiation-induced intestinal injury via regulating macrophage function Burns Trauma (IF 6.3) Pub Date : 2024-03-05 Lingling Wu, Long Chen, Huijuan Li, Yawei Wang, Kexin Xu, Wanchao Chen, Aihua Zhang, Yu Wang, Chunmeng Shi
Background Ionizing radiation (IR)-induced intestinal injury is a major side effect and dose-limiting toxicity in patients receiving radiotherapy. There is an urgent need to identify an effective and safe radioprotectant to reduce radiation-induced intestinal injury. Immunoregulation is considered an effective strategy against IR-induced injury. The purpose of this article was to investigate the protective
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The role of the skin microbiome in wound healing Burns Trauma (IF 6.3) Pub Date : 2024-03-05 Yuyan Yang, Jiuzuo Huang, Ang Zeng, Xiao Long, Nanze Yu, Xiaojun Wang
The efficient management of skin wounds for rapid and scarless healing represents a major clinical unmet need. Nonhealing skin wounds and undesired scar formation impair quality of life and result in high healthcare expenditure worldwide. The skin-colonizing microbiota contributes to maintaining an intact skin barrier in homeostasis, but it also participates in the pathogenesis of many skin disorders
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Luminol-conjugated cyclodextrin biological nanoparticles for the treatment of severe burn-induced intestinal barrier disruption. Burns Trauma (IF 6.3) Pub Date : 2024-03-03 Yajun Song,Yang Li,Wengang Hu,Feng Li,Hao Sheng,Chibing Huang,Xin Gou,Jingming Hou,Ji Zheng,Ya Xiao
Background The breakdown of intestinal barrier integrity occurs after severe burn injury and is responsible for the subsequent reactions of inflammation and oxidative stress. A new protective strategy for the intestinal barrier is urgently needed due to the limitations of the traditional methods. Recently, the application of nanoparticles has become one of the promising therapies for many inflammation-related
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Adipose mesenchymal stem cell-derived exosomes promote skin wound healing in diabetic mice by regulating epidermal autophagy Burns Trauma (IF 6.3) Pub Date : 2024-03-01 Zhe Wang, Haiyue Ren, Peng Su, Feng Zhao, Qiqi Zhang, Xing Huang, Cai He, Quan Wu, Zitong Wang, Jiajie Ma
Background Adipose mesenchymal stem cell-derived exosomes (ADSC-Exos) have great potential in the field of tissue repair and regenerative medicine, particularly in cases of refractory diabetic wounds. Interestingly, autophagy plays a role in wound healing, and recent research has demonstrated that exosomes are closely associated with intracellular autophagy in biogenesis and molecular signaling mechanisms
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Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids. Burns Trauma (IF 6.3) Pub Date : 2024-02-29 Siya Dai,Mingyuan Xu,Qianqian Pang,Jiaqi Sun,Xiaohu Lin,Xi Chu,Chunyi Guo,Jinghong Xu
Background Hypoxia is the typical characteristic of keloids. The development of keloids is closely related to the abnormal phenotypic transition of macrophages. However, the role of exosomal microRNAs (miRNAs) derived from hypoxic macrophages in keloids remains unclear. This study aimed to explore the role of hypoxic macrophage-derived exosomes (HMDE) in the occurrence and development of keloids and
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Matrix metalloproteinase-8 regulates dendritic cell tolerance in late polymicrobial sepsis via the nuclear factor kappa-B p65/β-catenin pathway Burns Trauma (IF 6.3) Pub Date : 2024-02-29 Zhong-qiu Lu, Chen Zhang, Lin-jun Zhao, Wei Dong, Liang Lv, Yang Lu, Xiao-Yan Chen, Jie Zhang, Xin-yong Liu, Zhong Xiao, Long-wang Chen, Yong-ming Yao, Guang-ju Zhao
Background Tolerogenic dendritic cells (DCs) are associated with poor prognosis of sepsis. Matrix metalloproteinases (MMPs) have been shown to have immunomodulatory effects. However, whether MMPs are involved in the functional reprogramming of DCs is unknown. The study aims to investigate the role of MMPs in sepsis-induced DCs tolerance and the potential mechanisms. Methods A murine model of late sepsis