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Labor epidural analgesia and subsequent risk of offspring autism spectrum disorder and attention-deficit/hyperactivity disorder: A cross-national cohort study of 4.5 million individuals and their siblings Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-13 Tor-Arne Hegvik, Kari Klungsøyr, Ralf Kuja-halkola, Hanna Remes, Jan Haavik, Brian M. D’onofrio, Niina Metsä-simola, Anders Engeland, Seena Fazel, Paul Lichtenstein, Pekka Martikainen, Henrik Larsson, Amir Sariaslan
Background A recent study has suggested that labor epidural analgesia may be associated with increased rates of offspring autism spectrum disorder (ASD). Subsequent replication attempts have lacked sufficient power to confidently exclude the possibility of a small effect and the causal nature of this association remains unknown. Objective To investigate the extent to which exposure to labor epidural
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First or second trimester SARS-CoV-2 infection and subsequent pregnancy outcomes Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-13 Brenna L. Hughes, Grecio J. Sandoval, Torri D. Metz, Rebecca G. Clifton, William A. Grobman, George R. Saade, Tracy A. Manuck, Monica Longo, Amber Sowles, Kelly Clark, Hyagriv N. Simhan, Dwight J. Rouse, Hector Mendez-figueroa, Cynthia Gyamfi-bannerman, Jennifer Bailit, Maged M. Costantine, Harish M. Sehdev, Alan T.N. Tita, George A. Macones
Background SARS-CoV2 infection during pregnancy is associated with adverse pregnancy outcomes including fetal death and preterm birth. It is not known whether that risk occurs only during the time of acute infection or whether risk persists later in pregnancy. Objective The goal of this analysis was to evaluate whether the risk of SARS-CoV-2 infection during pregnancy persists after acute maternal
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Umbilical cord milking in non-vigorous infants: A cluster-randomized crossover trial Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-13 Anup C. Katheria, Erin Clark, Bradley Yoder, Georg M. Schmölzer, Brenda Hiu Yan Law, Walid El-Naggar, David Rittenberg, Sheetal Sheth, Mohamed A. Mohamed, Courtney Martin, Farha Vora, Satyan Lakshminrusimha, Mark Underwood, Jan Mazela, Joseph Kaempf, Mark Tomlinson, Yvonne Gollin, Kevin Fulford, Madeline Murguia Rice
Background Delayed cord clamping (DCC) and umbilical cord milking (UCM) provide placental transfusion to vigorous newborns. Delayed cord clamping in non-vigorous newborns may not be provided due to perceived need for immediate resuscitation. UCM is an alternative since it can be performed more quickly than DCC and may confer similar benefits. Objective We hypothesized that UCM would reduce admission
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Placement of an intrauterine device within 48 hours after early medical abortion - a randomized controlled trial Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-13 Sara Hogmark, Karin Lichtenstein liljeblad, Niklas Envall, Kristina Gemzell-danielsson, Helena Kopp kallner
Background Intrauterine devices are safe, well tolerated and known to reduce the risk of unwanted pregnancies. At medical abortion, intrauterine devices are placed at a follow-up visit. Patients who miss this visit risk being left without contraception. Objective: To study if placement of an intrauterine device within 48 hours of completed medical abortion up to 63 days’ gestation leads to higher user
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Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetric disease Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-13 Raymond W. Redline, Drucilla J. Roberts, Mana M. Parast, Linda M. Ernst, Terry K. Morgan, Michael F. Greene, Cynthia Gyamfi-bannerman, Judette M. Louis, Emin Maltepe, Karen K. Mestan, Roberto Romero, Joanne Stone
The importance of a fully functioning placenta for a good pregnancy outcome is unquestioned. Loss of function can lead to pregnancy complications and is often detected by a thorough placental pathologic examination. Placental pathology has advanced the science and practice of obstetrics and neonatal-perinatal medicine by classifying diseases according to underlying biology and specific patterns of
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Impact of recurrent pregnancy loss history on the reproductive outcomes in women undergoing fertility treatment Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-13 Jiaxin Qiu, Tong Du, Wentao Li, Ming Zhao, Dong Zhao, Yun Wang, Yanping Kuang, Ben W. Mol
BACKGROUND Recurrent pregnancy loss negatively affects the reproductive outcomes of natural conception. Preimplantation genetic testing for aneuploidies has been the focus of interventions in women with recurrent pregnancy loss. However, the risk of no embryos being available, high costs, and uncertainties surrounding its effectiveness limit its use. Factors beyond euploidy, such as an appropriate
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Lactogenesis and breastfeeding after immediate versus delayed birth-hospitalization insertion of etonogestrel contraceptive implant: A non-inferiority trial Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-12 Andrea Henkel, Klaira Lerma, Griselda Reyes, Hanna Gutow, Jonathan G. Shaw, Kate A. Shaw
Background Initiating a progestin-based contraceptive prior to the drop in progesterone required to start lactogenesis stage II (LII) could theoretically impact lactation. Previous studies have shown that initiating progestin-based contraception in the postnatal period prior to birth-hospitalization discharge has no detriment on breastfeeding initiation or continuation compared to interval initiation
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Expression of Concern: Re: Shettles LB. Tubal embryo successfully transferred in utero. Am J Obstet Gynecol Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-10
Abstract not available
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Amniotic fluid sludge caused by intraamniotic bleeding Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-08 Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
Abstract not available
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The association between first trimester omega-3 fatty acid supplementation and fetal growth trajectories Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-08 Yassaman Vafai, Edwina Yeung, Anindya Roy, Dian He, Mengying Li, Stefanie N. Hinkle, William A. Grobman, Roger Newman, Jessica L. Gleason, Fasil Tekola-Ayele, Cuilin Zhang, Katherine L. Grantz
Background Prenatal omega-3 fatty acid supplementation, particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), has been associated with greater birthweight in clinical trials; however, its impact on fetal growth throughout gestation is unknown. Objective To examine the association between first trimester DHA/EPA supplementation and growth trajectories of estimated fetal weight and
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Assessment of baseline renal function tests to predict adverse outcomes in women with chronic hypertension. Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-08 Tetsuya Kawakita, Elizabeth Seagraves, Dana Baraki, Thomas Donaldson, Carole Barake, Alfred Abuhamad
Objective Chronic hypertension is a major health issue, complicating approximately 0.6-1.5 % of all pregnancies in the United States (US).1 Because kidneys are the first end-organ affected by hypertension, the rate of adverse effects can be related to baseline proteinuria.2, 3 Although the classic cutoff value of urine protein >300 mg/24-hour is widely accepted, it is not based on clinical outcomes
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cfDNA in maternal blood and Artificial Intelligence: Accurate Prenatal Detection of Fetal Congenital Heart Defects Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-07 Ray Bahado-singh, Perry Friedman, Ciara Talbot, Buket Aydas, Siddesh Southekal, Nitish K. Mishra, Chittibabu Guda, Ali Yilmaz, Uppala Radhakrishna, Sangeetha Vishweswaraiah
Background DNA cytosine nucleotide methylation (epigenomics/ epigenetics) is an important mechanism for controlling gene expression in cardiac development. Combined Artificial Intelligence (AI) and whole-genome epigenomic analysis of circulating cell free DNA (cfDNA) in maternal blood has the potential for the detection of fetal congenital heart defects (CHD). Objective To use genome-wide DNA cytosine
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The Cardio-Feto-Placental unit: fetal umbilical vein flow rate is linked to the maternal cardiac profile in fetal growth restriction. Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-06 Herbert Valensise, Daniele Farsetti, Francesca Pometti, Barbara Vasapollo, Gian Paolo Novelli, Christoph Lees
BACKGROUND The functional maternal-fetal hemodynamic unit includes fetal umbilical vein flow and maternal peripheral vascular resistance. OBJECTIVE We investigated the relationships between maternal and fetal hemodynamics in a population with suspected fetal growth restriction. STUDY DESIGN This was a prospective study of normotensive pregnancies referred to our outpatient clinic for a suspected fetal
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Bullous Pemphigoid in a Lichen Sclerosus Lesion Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-06 Neill Boeijink, Esther R. Klompmaker, Michiel P.J. van der Horst, Tim van Meurs
Abstract not available
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African Ancestry is Associated with Aggressive Endometrial Cancer Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-06 Alex P. Sanchez-Covarrubias, Angel D. Tabuyo-Martin, Sophia George, Matthew Schlumbrecht
Abstract not available
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General Health in a cohort of children conceived after assisted reproductive technology in the UK: a population-based record-linkage study Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Alastair G. Sutcliffe, Mitana Purkayastha, Daniel R. Brison, Scott M. Nelson, Stephen A. Roberts, Deborah A. Lawlor
Background Assisted reproductive technology usage is increasing annually; however, data on long-term child health outcomes including hospital admissions is limited. Objectives To examine the potential effects of assisted reproductive technology on any and cause-specific hospital admissions not related to perinatal diagnoses. Study design Population-based record-linkage study utilizing a previously
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The influence of pregnancy, parity, and mode of delivery on urinary incontinence and prolapse surgery – a national register study Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-03 J. Larsudd-Kåverud, J. Gyhagen, S. Åkervall, M. Molin, I. Milsom, A. Wagg, M. Gyhagen
BACKGROUND The long-term effects of vaginal delivery, parity, and pregnancy on the pelvic floor remain uncertain and controversial issues. In comparison with studies using self-reported symptoms, surgical register data may offer a more valid mean for evaluating the relative influence of these risk factors. OBJECTIVES This study used data from three high-quality nationwide registers, the Swedish National
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The Prenatal Detection of Distal Tracheoesophageal Fistulas in Fetuses Diagnosed with Esophageal Atresia Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-05 Tal WEISSBACH, Anya KUSHNIR, Shayan YOUSEFI, Abeer MASSARWA, Leah LEIBOVITCH, Denise-Dana FRANK, Debora KIDRON, Reuven ACHIRON, Raanan MEYER, Boaz WEISZ, Shali MAZAKI TOVI, Eran KASSIF
Objective Esophageal atresia is a major anomaly of varying severity. The complexity of surgical correction depends on the presence of a distal fistula. The aim of this study was to determine the feasibility and accuracy of prenatal ultrasound detection of the distal fistula in fetuses diagnosed with esophageal atresia. Methods This was an observational study conducted at a single tertiary care center
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Advantages of intraoperative staging and topographic classification in PAS Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-05 Albaro Jose Nieto Calvache, Juan Pablo Benavides
Abstract not available
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Natural history of lower urinary tract symptoms in treatment-seeking women with pelvic organ prolapse; the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-05 Joseph T. Kowalski, Jonathan B. Wiseman, Abigail R. Smith, Margaret E. Helmuth, Anne Cameron, John O.L. Delancey, Whitney K. Hendrickson, J. Eric Jelovsek, Anna Kirby, Karl Kreder, H. Henry Lai, Margaret Mueller, Nazema Siddiqui, Catherine S. BRADLEY
Background The association of pelvic organ prolapse with overactive bladder, other lower urinary tract symptoms (LUTS), and the natural history of those symptoms is not well characterized. Previous cross-sectional studies demonstrated conflicting relationships between prolapse and LUTS. Objectives Primary aims were to determine the baseline association between LUTS and prolapse and to assess longitudinal
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Scientific, Ethical, and Legal Considerations for the Inclusion of Pregnant People in Clinical Trials Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Catherine A. Sewell, Sarah M. Sheehan, Mira S. Gill, Leslie M. Henry, Christina Bucci-Rechtweg, Cynthia Gyamfi-Bannerman, Anne D. Lyerly, Leslie C. Mckinney, Kimberly P. Hatfield, Gerri R. Baer, Leyla Sahin, Christine P. Nguyen
Clinical trials to address the COVID-19 public health emergency have broadly excluded pregnant people from participation, illustrating a long-standing trend of clinical trial exclusion that has led to a clear knowledge gap and unmet need in the treatment and prevention of medical conditions experienced during pregnancy or of pregnancy-related conditions. Drugs1 approved for a certain medical condition
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Characteristics Associated with Composite Surgical Failure Over 5 Years of Women in a Randomized Trial of Sacrospinous Hysteropexy With Graft versus Vaginal Hysterectomy With Uterosacral Ligament Suspension Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Holly E. Richter, Amaanti Sridhar, Charles W. Nager, Yuko M. Komesu, Heidi S. Harvie, Halina M. Zyczynski, Charles Rardin, Anthony Visco, Donna Mazloomdoost, Sonia Thomas
Background Among women with symptomatic uterovaginal prolapse undergoing vaginal surgery in the Vaginal hysterectomy with Native Tissue Vault Suspension vs Sacrospinous Hysteropexy with Graft Suspension (Study for Uterine Prolapse Procedures-Randomized Trial (SUPeR) trial, sacrospinous hysteropexy with graft (hysteropexy) resulted in a lower composite surgical failure rate compared to vaginal hysterectomy
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Endocervical sampling in women with suspected cervical neoplasia: A systematic review and meta-analysis of diagnostic test accuracy studies Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Mathias Damkjær, Jacob Brink Laursen, Lone Kjeld Petersen, Doris Schledermann, Berit Bargum Booth, Britta Blume Dolleris, Henrik Sehested Laursen, Jeppe Schroll
Objective Endocervical sampling in women with suspected cervical neoplasia can be obtained by either endocervical brush or endocervical curettage. We aimed to estimate the diagnostic accuracy, discomfort and number of inadequate samples with either test. Data sources Four bibliographic databases were searched on the 9th of June 2022, with no date or language restrictions. Study eligibility criteria
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The introduction of a universal transvaginal cervical length screening program is associated with a reduced preterm birth rate Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Aude Figarella, Cécile Chau, Anderson Loundou, Claude d’Ercole, Florence Bretelle
Background Midtrimester sonographic short cervix is a good predictor of preterm birth in singleton pregnancies. Objective To assess the impact on preterm birth rate after implementation of a universal transvaginal cervical length screening program. Study design This study was made up of two parts: a before-and-after multicenter study and a study on the ECHOCOL prospective cohort. We compared the rate
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Associations between provider-assigned Apgar score and neonatal race Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Sara E. Edwards, Catherine Wheatley, Monique Sutherland, Quetzal A. Class
Background For decades, the Apgar scoring system has been used to evaluate neonatal status and determine need for resuscitation or escalation in care, such as admission to a Neonatal Intensive Care Unit. However, variation and accuracy of provider-assigned Apgar scores across neonatal racial groups has yet to be evaluated. Objective To investigate how provider-assigned Apgar scores vary by neonatal
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Pregnancy outcome of confined placental mosaicism: meta-analysis of cohort studies. Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Silvia L. Spinillo, Antonio Farina, Alexandros Sotiriadis, Mirko Pozzoni, Sabrina Giglio, Margherita Papale, Massimo Candiani, Paolo I. Cavoretto
Objective To assess the rate of adverse obstetric and neonatal outcomes in pregnancies diagnosed with confined placental mosaicism vs. unaffected controls. Data sources Web-based databases searched using relevant keywords and retrieved articles published from 1980 to February 2022. Study eligibility criteria Observational studies in English language including at least 10 cases of singleton pregnancies
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Risk of endometrial cancer in asymptomatic postmenopausal women in relation to ultrasonographic endometrial thickness. Systematic review and diagnostic test accuracy meta-analysis. Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Salvatore Giovanni Vitale, Gaetano Riemma, Sergio Haimovich, Jose Carugno, Luis Alonso Pacheco, Tirso Perez-Medina, John Preston Parry, Peter Török, Jan Tesarik, Luigi Della Corte, Luigi Cobellis, Attilio Di Spiezio Sardo, Pasquale De Franciscis
Objective To evaluate the risk of endometrial carcinoma (EC) and atypical endometrial hyperplasia (AEH) in asymptomatic postmenopausal women in relation to the endometrial thickness (ET) measured by transvaginal ultrasonography (TVS) stratified by threshold categories used for performing subsequent endometrial sampling and histologic evaluation. Data sources MEDLINE, Scopus, ClinicalTrials.gov, Scielo
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A Systematic Review and In Silico Study of Potential Genetic Markers Implicated in Cases of Overactive Bladder Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Ilaha Isali, Phillip McClellan, Thomas R. Wong, Clara Sun, Amber Catherine Stout, Fredrick R. Schumacher, Sarah Markt, Chen-Han Wilfred Wu, Kathryn L. Penney, Sherif El-Nashar, Adonis Hijaz, David Sheyn
Objective The contribution of genetic factors to the presence of overactive bladder (OAB) is recognized. This study aimed to: (1) assemble and synthesize available data from studies assessing differential gene expression in OAB patients compared to non-OAB controls and (2) determine possible correlations and functional pathways between genes. Data sources We searched PubMed, Ovid/Medline, and Wiley
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Early natural menopause is associated with poor lung health and increased mortality among female smokers Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Ting Zhai, Brenda Diergaarde, David O. Wilson, Huining Kang, Akshay Sood, Samuel H. Bayliss, Jian-Min Yuan, Maria A. Picchi, Qing Lan, Steven A. Belinsky, Jill M. Siegfried, Linda S. Cook, Shuguang Leng
Background Early natural menopause has been regarded as a biomarker of reproductive and somatic aging. Cigarette smoking is the most detrimental factor for lung health and also an established risk factor for early menopause. Understanding the impact of early menopause on health outcomes in mid-life and older female smokers is important to develop preventive strategies. Objective This study aimed to
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Age-specific random day serum anti-Mullerian hormone reference values for women of reproductive age in the general population: a large Chinese nationwide population-based survey Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Yongxiu Hao, Rui Yang, Jia Li, Zehong Zhou, Weiping Qian, Jian Zhang, Ze Wu, Lei Jin, Xueqing Wu, Cuilian Zhang, Beihong Zheng, Jichun Tan, Guimin Hao, Shangwei Li, Qin Li, Danni Zheng, Yuanyuan Wang, Rong Li, Jie Qiao
Background Anti-Mullerian hormone, the most reliable biomarker of ovarian reserve, is widely used in various clinical situations. Anti-Mullerian hormone levels consistently decrease with age. However, there are no standard, age-specific reference values for anti-Mullerian hormone in women of reproductive age, which limits its application. Objective To establish age-specific anti-Mullerian hormone centile
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Municipal smoke-free laws and preterm birth Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-04 Kristin B. Ashford, Lisa M. Blair, Andrea K. Mccubbin, Amanda T. Wiggins, Mary Kay Rayens, Ellen J. Hahn
Background Smoking during pregnancy and prenatal secondhand smoke exposure increase risk for preterm birth. As Kentucky has the second highest rate of smoking in the US and no statewide smoke-free law, examination of the impact of municipal smoke-free legislation on preterm birth is warranted. Objective This study used state-level live birth data and county-level municipal smoke-free legislation status
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The Complex Challenge of Antenatal Steroid Therapy Non-Responsiveness Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-03 Tsukasa Takahashi, Alan H. Jobe, Erin L. Fee, John P. Newnham, Augusto F. Schmidt, Haruo Usuda, Matthew W. Kemp
Antenatal steroid (ANS) therapy is standard care for women at imminent risk of preterm delivery. When deliveries occur within seven days of treatment, ANS therapy reduces the risk of neonatal death and improves preterm outcomes by exerting diverse developmental effects on the fetal organs, in particular the preterm lung and cardiovascular system. There is, however, sizable variability in ANS treatment
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Postpartum Urinary Retention: An Expert Review Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-03 Alexandra C. NUTAITIS, Nicole A. MECKES, Annetta M. MADSEN, Coralee T. TOAL, Kimia MENHAJI, Charelle M. CARTER-BROOKS, Katie A. PROPST, Lisa C. HICKMAN
Postpartum urinary retention is a relatively common condition that can have a significant impact on women in the immediate days following childbirth. If left untreated, postpartum urinary retention can lead to repetitive overdistention injury that may damage the detrusor muscle and the parasympathetic nerve fibers within the bladder wall. In rare circumstances, postpartum urinary retention may even
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Placental pathology and risk of recurrent preterm birth Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-03 Yong-Shan Chen, Jie-Fu He, Dong-Zhi Li
Abstract not available
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Syphilis in Pregnancy: An Ongoing Public Health Threat Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-03 C. Eppes, I. Stafford, M. Rac
Syphilis is a treponemal infection that can be acquired sexually, hematogenous or via vertical transmission from mother to infant. Despite evidence-based curative treatment options with penicillin, it remains a public health threat with increasing prevalence over recent years. Congenital syphilis, a condition where a fetus acquires the infection during pregnancy, can lead to stillbirth, miscarriage
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Author Response to Comment: Placental Pathology and Recurrent Preterm Birth Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-03 Sunitha Suresh, Alexa Freedman, Linda Ernst
Abstract not available
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Vaginal progesterone does not prevent recurrent preterm birth in women with a singleton gestation, a history of spontaneous preterm birth, and a midtrimester cervical length >25 mm Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Agustin Conde-Agudelo, Roberto Romero
Abstract not available
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Unified Standard for Fetal Growth Velocity: the NICHD Fetal Growth Studies Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Katherine L. Grantz, Jagteshwar Grewal, Sungduk Kim, William A. Grobman, Roger B. Newman, John Owen, Anthony Sciscione, Daniel Skupski, Edward K. Chien, Deborah A. Wing, Ronald J. Wapner, Angela C. Ranzini, Michael P. Nageotte, Sabrina Craigo, Stefanie N. Hinkle, Mary E. D’alton, Dian HE, Fasil Tekola-Ayele, Paul S. Albert
Abstract not available
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You’re on mute: OB/GYN perspectives on the transition to virtual grand rounds Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Sarah K. Dotters-Katz, Matthew R. Grace, Jessica Mcpherson, Beverly Gray, Anthony Shanks, Lisa G. Hofler
Abstract not available
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Is the phase of the menstrual cycle relevant when getting the covid-19 vaccine? Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Borja Velasco-Regulez, Jose L. Fernandez-Marquez, Nerea Luqui, Jesus Cerquides, Analia Fukelman, Josep PERELLÓ
Abstract not available
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Placenta Percreta: Time to close a 50-year-old “Pandora’s box” Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Eric Jauniaux, Jonathan L. Hecht, Ahmed M. Hussein
Abstract not available
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Less is more: Clinical utility of postoperative labs following minimally invasive hysterectomy for endometrial cancer. Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Michelle D.S. LIGHTFOOT, Ashley S. FELIX, Corinne A. CALO, John T. HOSMER-QUINT, Krista L. TAYLOR, Melissa B. BROWN, Ritu SALANI, Larry J. Copeland, David M. O’MALLEY, Kristin L. BIXEL, David E. COHN, Jeffrey M. FOWLER, Floor J. BACKES, Casey M. COSGROVE
Background With the increasing rates of same day discharge following minimally invasive surgery for endometrial cancer, the need for and value of routine postoperative testing is unclear. Objective To determine whether routine postoperative labs following minimally invasive hysterectomy for endometrial cancer leads to clinically significant changes in postoperative care. Study Design This is a single-institution
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Effect of Pentaerythrityltetranitrate (PETN) on the development of fetal growth restriction in pregnancies with impaired uteroplacental perfusion at mid gestation – a randomised trial Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Tanja Groten, Thomas Lehmann, Mariann Städtler, Matej Komar, Jennifer Lucia Winkler, Mateja Condic, Brigitte Strizek, Sven Seeger, Yvonne Jäger, Ulrich Pecks, Christel Eckmann-Scholz, Karl Oliver Kagan, Markus Hoopmann, Constantin S. von Kaisenberg, Lars Brodowski, Anne Tauscher, Susanne Schrey-Petersen, Ulrike Friebe-Hoffmann, Ekkehard Schleußner
Background Fetal growth restriction is strongly associated with impaired placentation and abnormal utero-placental blood flow. NO-donors like PETN are strong vasodilators and protect the endothelium. Recently, we demonstrated in a randomized controlled pilot-study a 38% relative risk reduction for the development of fetal growth restriction or perinatal death, following administration of PETN to pregnant
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Cytomegalovirus vulvar ulceration in patient without HIV-AIDS Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Hunter J. Pyle, Melissa M. Mauskar, Arturo R. Dominguez
Abstract not available
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Does acute funisitis predict worse neonatal outcomes among term newborns? Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-08-02 Gregory E. Zemtsov, Nicole Diaz, Emma Ryan, Agnes Chao, Carmen M. Avram, Matthew R. Grace, Sarah K. Dotters-Katz
Background Acute funisitis, the histologic diagnosis of inflammation within the umbilical cord, represents fetal inflammatory response to infection. While acute funisitis has been associated with an increased risk of adverse outcomes among preterm neonates, there are limited and conflicting data with term deliveries. Objective We aim to evaluate the association between acute funisitis and neonatal
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Long-term childhood outcomes for babies born at term who were exposed to antenatal corticosteroids Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-21 Samantha J. Osteen, Ziyi Yang, Alexandra H. Mckinzie, Evgenia Teal, Robert S. Tepper, Eli Rhoads, Sara K. Quinney, Laura S. Haneline, David M. Haas
Background Antenatal corticosteroids (ACS) improve neonatal outcomes when administered to infants who are at risk of preterm delivery. Many women who receive ACS for threatened preterm labor go on to deliver at term. Thus, long-term outcomes should be evaluated for term-born infants who were exposed to ACS in-utero Objective The objective of this study was to compare the long-term outcomes of term-born
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First trimester nuchal translucency measurements: using a transverse or sagittal plane? Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-21 Li Zhen, Dong-Zhi Li
Abstract not available
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Human Leukocyte Antigen HLA-C, HLA-G, HLA-F and HLA-E placental profiles are altered in Early Severe Preeclampsia and Preterm Birth with Chorioamnionitis. Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Caroline E. Dunk, Matthew Bucher, Jianhong Zhang, Heyam Hayder, Daniel E. Geraghty, Stephen J. Lye, Leslie Myatt, Rinat Hackmon
Background The extravillous trophoblast expresses each of the non-classical MHC class I antigens - HLA-E, F, and G and a single classical class I antigen HLA-C. We recently demonstrated dynamic expression patterns of HLA-C, G and F during early EVT invasion and placentation. Objective In this study we investigate the hypothesis that the immune inflammatory mediated complications of pregnancy such as
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Non-invasive prediction models of intraamniotic infection in women with preterm labor Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-20 Teresa COBO, Xavier P. BURGOS-ARTIZZU, M Carmen COLLADO, Vicente ANDREU, Ana B. SANCHEZ-GARCIA, Xavier FILELLA, Silvia MARIN, Marta CASCANTE, Jordi BOSCH, Silvia FERRERO, David BOADA, Clara MURILLO, Claudia RUEDA, Júlia PONCE, Montse PALACIO, Eduard GRATACOS
Background Among women with preterm labor, those with intra-amniotic infection present the highest risk of early delivery and the most adverse outcomes. Identification of intra-amniotic infection requires amniocentesis, perceived as too invasive by women and physicians. Non-invasive methods for identifying intra-amniotic infection and/or early delivery are critical to focus early efforts on high-risk
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COVID-19 booster dose induces robust antibody response in pregnant, lactating, and nonpregnant women Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Caroline Atyeo, Lydia L. Shook, Nadege Nziza, Elizabeth A. Deriso, Ms. Cordelia Muir, Ms. Arantxa Medina baez, Ms. Rosiane S. Lima, Mr. Stepan Demidkin, Ms. Sara Brigida, Rose M. De guzman, Ms. Madeleine D. Burns, Alejandro B. Balazs, Alessio Fasano, Lael M. Yonker, Kathryn J. Gray, Galit Alter, Andrea G. Edlow
BACKGROUND While emerging data during the SARS-CoV-2 pandemic have demonstrated robust mRNA vaccine-induced immunogenicity across populations, including pregnant and lactating individuals, the rapid waning of vaccine-induced immunity and the emergence of variants of concern motivated the use of mRNA vaccine booster doses. Whether all populations, including pregnant and lactating individuals, will mount
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Placental Transcriptomic Signatures of Spontaneous Preterm Birth Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Alison G. Paquette, James Macdonald, Theo Bammler, Drew B. Day, Christine T. Loftus, Erin Buth, W. Alex Mason, Nicole R. Bush, Kaja Z. Lewinn, Carmen Marsit, James A. Litch, Michael Gravett, Daniel A. Enquobahrie, Sheela Sathyanarayana
Background Spontaneous preterm birth accounts for the majority of preterm births and results in significant morbidity in the newborn and childhood period. This subtype of preterm birth represents an increasing proportion of all preterm births compared to medically indicated preterm birth, yet is understudied in ‘Omics analyses. The placenta is a key regulator of fetal and newborn health, and the placental
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The impact of insurance mandates on donor oocyte utilization: an analysis of 39,338 donor oocyte cycles from the Society for Assisted Reproductive Technology registry. Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Jenny S. George, Malinda S. Lee, Rachel K. Ashby, Randi Goldman, Elizabeth S. Ginsburg, Andrea Lanes, Serene S. Srouji
Background Nineteen states passed legislation mandating insurance coverage of assisted reproductive technology (ART), and out-of-pocket costs associated with in vitro fertilization (IVF) vary significantly depending on the region. Consequently, it has been observed that ART utilization differs regionally and is associated with the presence of an insurance mandate. However, it is unknown whether regional
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Invasive diagnosis after first trimester aneuplody screening Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Elisa MONTAGUTI, Gianluigi PILU
Abstract not available
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Single Second Trimester Cervical Length is Predictive of Preterm Delivery Among Patients with Prophylactic Cerclage Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Sunitha Suresh, Caitlin MacGregor, Annie Dude, Emmet Hirsch
Abstract not available
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Alternative to intensive management of the active phase of the second stage of labor: a multicenter randomized trial (PASST trial) among nulliparous women with an epidural Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Camille Le Ray, Patrick Rozenberg, Gilles Kayem, Thierry Harvey, Jeanne Sibiude, Muriel Doret, Olivier Parant, Florent Fuchs, Delphine Vardon, Elie Azria, Marie-Victoire Sénat, Pierre-François Ceccaldi, Aurélien Seco, Charles Garabedian, Anne Alice Chantry
Background There is no consensus on an optimal strategy for managing the active phase of the second stage of labor. Intensive pushing could reduce pushing duration, but also increase abnormal fetal heart rate due to cord compression and to the reduced placental perfusion and oxygenation resulting from the combination of uterine contractions and maternal expulsive forces. It may therefore increase the
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SARS-CoV-2 Immunoglobulin G Antibody Levels in Infants Following Messenger RNA COVID-19 Vaccination During Pregnancy Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Nir Kugelman, Chen Nahshon, Pninit Shaked-Mishan, Ofer Lavie, Nili Stein, Reuven Kedar, Dan Waisman
Abstract not available
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Phase 3 Study of the Safety and Efficacy of Oteseconazole in Treatment of Recurrent Vulvovaginal Candidiasis and Efficacy vs Fluconazole in Treatment of Acute Vulvovaginal Candidiasis Infections Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-19 Mark G. Martens, Bassem Maximos, Thorsten Degenhardt, Karen Person, Stacey Curelop, Mahmoud Ghannoum, Amy Flynt, Stephen R. Brand
Background Recurrent vulvovaginal candidiasis (RVVC) affects nearly 138 million women globally each year. In the US, fluconazole is considered standard of care for acute vulvovaginal candidiasis (VVC), but there are currently no US Food and Drug Administration–approved drugs for the treatment of RVVC. Oteseconazole is a novel oral selective inhibitor of fungal lanosterol demethylase (CYP51, an enzyme
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Information for readers Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-20
Abstract not available
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AJOG MFM Table of Contents Am. J. Obstet. Gynecol. (IF 10.693) Pub Date : 2022-07-20
Abstract not available