INTRODUCTION Non-immune hydrops fetalis (NIHF) is well understood to be heterogenous and the common endpoint of many genetic diseases. However, less is known about the prevalence and presenting features of genetic diseases that underlie other types of fetal effusions such as single effusions, leaving uncertainty in clinical practice about optimal approaches to testing and counseling for these pregnancies

BACKGROUND The proportion of term hypoxic-ischemic encephalopathy arising during intrapartum fetal surveillance remains unclear. Moreover, recent Cochrane review and other studies emphasized the need for research on the impact of admission cardiotocography, and highlighted the necessity for a definition of 'avoidable perinatal brain injury'. OBJECTIVE To assess the impact of intrapartum asphyxia on

OBJECTIVE Access to abortion has changed dramatically in the United States in recent years, both at the federal and state level. For nearly fifty years, the right to abortion was considered federally protected right under the Roe v. Wade (1973) recognition of privacy rights under the 14th Amendment. In September 2021, Texas passed SB8 which implemented a 6-week restriction on access to abortion. The

BACKGROUND Current evidence indicates that administration of vaginal progesterone to women with a twin gestation and a short cervix reduces the risk of preterm birth occurring at early gestational ages and of neonatal morbidity and mortality. However, the potential long-term effects of prenatal administration of vaginal progesterone for preventing preterm birth on the psychopathological and cognitive

OBJECTIVE Understanding the rates and timing of postpartum complications can facilitate timely screening and management to reduce preventable morbidity and mortality. The aim of this study was to summarize the frequency (prevalence or incidence) and timing of complications from hospital delivery to one year postpartum in the United States and Canada. DATA SOURCES PubMed MEDLINE, Web of Science, EBSCO

BACKGROUND Recognized by the World Health Organization as a disease, infertility carries emotional and financial burdens. With treatments like in vitro fertilization (IVF) costing approximately $12,400 (not including medications), many Americans may allocate a substantial portion of their annual income to a single assisted reproductive technology (ART) cycle. To mitigate this burden, a minority of

BACKGROUND Down syndrome, first systematically characterized by John Langdon Down in 1866 and later identified as trisomy 21 by Jérôme Lejeune in 1959, has seen dramatic improvements in life expectancy due to advances in medical care and social support. Despite this progress and the National Institutes of Health's INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE

Babies affected by late fetal growth restriction are at risk of adverse perinatal outcomes, either due to placental insufficiency or the consequences of late iatrogenic prematurity. There is no randomized trial reporting the optimal timing of delivery and recommending delivery at 37 weeks can cause harm. Antenatal ultrasound parameters can be used to risk stratify late fetal growth restriction pregnancies

Enhanced recovery after cesarean delivery protocols include evidence-based interventions which are designed to improve patient experience and maternal and neonatal outcomes, whilst reducing healthcare related costs. This is the first update to the Enhanced Recovery After Surgery Society guidelines for intraoperative care in cesarean delivery published in 2018. Interventions were selected based on expert

Enhanced recovery after cesarean delivery protocols include evidence-based interventions designed to improve patient experience, pregnancy, and neonatal outcomes while reducing healthcare-related costs. This is the first update of the Enhanced Recovery After Surgery Society guidelines for antenatal and preoperative care before cesarean delivery after the original publication in 2018.

Enhanced Recovery After Cesarean Delivery (ERAC) protocols include evidence-based interventions designed to improve maternal and neonatal outcomes and patient experiences while reducing healthcare-related costs. This is the first update to the Enhanced Recovery After Surgery Society guidelines for postoperative care in cesarean delivery published in 2019. Interventions were selected based on expert

OBJECTIVE Mainstreaming genetic testing refers to genetic testing for cancer susceptibility genes following cancer diagnosis, which is provided by non-genetics health professionals of the cancer-treating team. Mainstreaming can be used to guide cancer treatment and secondary cancer prevention in the patient, and to identify carriers in the family members of patients who test positive through cascade

OBJECTIVE To determine the absolute and relative risks of adverse maternal, perinatal, and longer-term child outcomes for pregnancies with antenatally-detected early-onset small for gestational age fetuses, compared with baseline population rates. STUDY DESIGN We linked ultrasound data from pregnancies with antenatally-detected, non-anomalous, early-onset SGA fetuses (estimated fetal weight and/or

Generative artificial intelligence chatbots are sophisticated conversational artificial intelligence tools that have the capability to interpret natural language inputs and produce responses that closely resemble human speech. Artificial intelligence chatbots hold significant promise in revolutionizing medical education by offering invaluable support across various educational domains, including teaching

BACKGROUND Since professional societies recommended counseling patients about opportunistic salpingectomy (OS) for ovarian cancer risk reduction, use of OS has increased overall. However, physicians varied in their adoption of this new cancer prevention strategy. OBJECTIVES To examine peer influence among physicians as one possible factor affecting their adoption of OS at the time of hysterectomy.

Thin endometrium is defined as an endometrial thickness of less than 7 mm in the midluteal phase of the menstrual cycle, a condition often seen in women of childbearing age with a history of uterine trauma, such as dilation and curettage or intrauterine adhesion separation. This inadequate thickness poses a substantial threat to endometrial receptivity and subsequent pregnancy, particularly during

The ovaries play a crucial role in both the endocrine health and fertility of adult women. The fundamental functional units of the ovaries, primordial follicles, form during fetal development and constitute the ovarian reserve. Ovaries age prematurely in comparison to other organs, with the quality of oocytes declining steeply prior to the entire reserve becoming depleted, usually around age 50. Despite

Single-cell technologies have emerged as an unprecedented tool for biologists and clinicians, allowing them to assess organs and tissues at the level of individual cells. In the field of women's reproductive biology, single-cell studies have provided insights into the cellular and molecular processes that regulate reproductive and obstetrical functions in health and disease. The knowledge that these

The maternal-fetal interface represents a critical site of immunological interactions that can greatly influence pregnancy outcomes. The unique cellular composition and cell-cell interactions taking place within these tissues has spurred substantial research efforts focused on the maternal-fetal interface. With the recent advent of single-cell technologies, multiple investigators have applied such

Uterine leiomyomas or fibroids are benign tumors of the myometrium that affect approximately 70% of reproductive-age women. Fibroids continue to be the leading cause of hysterectomy, resulting in substantial healthcare costs. Genetic complexity and lack of cellular and molecular understanding of fibroids have posed considerable challenges to developing noninvasive treatment options. Over the years

Genital hiatus enlargement is associated with pelvic organ prolapse and overactive bladder 5 to 10 years after first delivery. It is unknown if this association is present earlier postpartum.

OBJECTIVE The study aimed to evaluate whether women with singleton pregnancies who experienced subsequent placental abruption had lower serum placental growth factor concentrations, higher serum soluble fms-like tyrosine kinase-1 concentrations, and a higher soluble fms-like tyrosine kinase-1/placental growth factor ratio compared to women with singleton pregnancies without placental abruption. DATA