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Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth Circulation (IF 37.8) Pub Date : 2024-03-15 Tal Caller, Itai Rotem, Olga Shaihov-Teper, Daria Lendengolts, Yeshai Schary, Ruty Shai, Efrat Glick-Saar, Dan Dominissini, Menachem Motiei, Idan Katzir, Rachela Popovtzer, Merav Nahmoud, Alex Boomgarden, Crislyn D’Souza-Schorey, Nili Naftali-Shani, Jonathan Leor
BACKGROUND:Myocardial infarction (MI) and heart failure are associated with an increased incidence of cancer. However, the mechanism is complex and unclear. Here, we aimed to test our hypothesis that cardiac small extracellular vesicles (sEVs), particularly cardiac mesenchymal stromal cell–derived sEVs (cMSC-sEVs), contribute to the link between post-MI left ventricular dysfunction (LVD) and cancer
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Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-03-11 Salim S. Hayek, Vlad G. Zaha, Carmel Bogle, Anita Deswal, Amelia Langston, Seth Rotz, Alexi Vasbinder, Eric Yang, Tochukwu Okwuosa, on behalf of the American Heart Association Cardio-Oncology Committee of the Council on Clinical Cardiology and Council on Genomic and Precision Medicine, and the Council on Cardiovascular and Stroke Nursing
Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, but guidelines are lacking. This American Heart Association scientific statement summarizes the data on transplantation-related complications and provides guidance
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Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With or Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials Circulation (IF 37.8) Pub Date : 2024-03-11 Prakriti Gaba, Joseph F. Sabik, Sabina A. Murphy, Andrea Bellavia, Patrick T. O’Gara, Peter K. Smith, Patrick W. Serruys, A. Pieter Kappetein, Seung-Jung Park, Duk-Woo Park, Evald H. Christiansen, Niels R. Holm, Per H. Nielsen, Marc S. Sabatine, Gregg W. Stone, Brian A. Bergmark
BACKGROUND:Diabetes may be associated with differential outcomes in patients undergoing left main coronary revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The aim of this study was to investigate outcomes in patients with left main disease with and without diabetes undergoing PCI versus CABG.METHODS:Individual patient data were pooled from
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Correction to: 2023 Scientific Sessions Abstract 18987 Circulation (IF 37.8) Pub Date : 2024-03-11
In the 2023 Scientific Sessions abstract by Umrani et al, “Abstract 18987: A 10-Year Contemporary Analysis of Outcomes of Patients With Amyloidosis and VT Underdoing Ventricular Tachycardia (VT) Ablation,” which published on November 6, 2023 (Circulation. 2023;148:A18987. DOI: 10.1161/circ.148.suppl_1.18987), a correction is needed. In the author byline, author “Yaser Khallid” has been updated to read
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Antiarrhythmic Drug Therapy: Where Do We Go From Here? Circulation (IF 37.8) Pub Date : 2024-03-11 Peter R. Kowey, Gerald V. Naccarelli
Most sufferers with heart disease cannot be cured. The purpose of intelligent care is the prolongation of life, the diminution of suffering, and the increase in the mental and physical efficiency of the patient. — Samuel Levine, Clinical Heart Disease Fourth Edition, Saunders, 1951 Antiarrhythmic drugs have been and will remain the mainstay of the chronic therapy of patients who have cardiac arrhythmias
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Correction to: Development and Validation of the American Heart Association’s PREVENT Equations Circulation (IF 37.8) Pub Date : 2024-03-11
In the article by Khan et al, “Development and Validation of the American Heart Association’s PREVENT Equations,” which appeared in the February 6, 2024, issue of the journal (Circulation. 2024;149:430–449. DOI: 10.1161/CIRCULATIONAHA.123.067626), a correction is needed. On page 433, the year range in the following sentence was updated from 2015–2020 to 2015–2019, to read, “The SDI was calculated at
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Correction to: 2023 Scientific Sessions Abstract 18918 Circulation (IF 37.8) Pub Date : 2024-03-11
In the 2023 Scientific Sessions abstract by Umrani et al, “Abstract 18918: Outcomes of Patients With Transcatheter Aortic Valve Replacement (TAVR) and Cardiac Resynchronization Therapy (CRT): A Retrospective Analysis,” which published on November 6, 2023 (Circulation. 2023;148:A18918. DOI: 10.1161/circ.148.suppl_1.18918), a correction is needed. In the author byline, Yaser Khalid has been added as
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Status and Future Directions for Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Disease With and Without Pulmonary Hypertension: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-03-07 Vikas Aggarwal, Jay Giri, Scott H. Visovatti, Ehtisham Mahmud, Hiromi Matsubara, Michael Madani, Frances Rogers, Deepa Gopalan, Kenneth Rosenfield, Vallerie V. McLaughlin, on behalf of the American Heart Association Council on Clinical Cardiology, Council on Peripheral Vascular Disease, Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, and Council on Cardiovascular and Stroke
Balloon pulmonary angioplasty continues to gain traction as a treatment option for patients with chronic thromboembolic pulmonary disease with and without pulmonary hypertension. Recent European Society of Cardiology guidelines on pulmonary hypertension now give balloon pulmonary angioplasty a Class 1 recommendation for inoperable and residual chronic thromboembolic pulmonary hypertension. Not surprisingly
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Toward Heart-Healthy and Sustainable Cities: A Policy Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-03-04 Sanjay Rajagopalan, Anu Ramaswami, Aruni Bhatnagar, Robert D. Brook, Mark Fenton, Christopher Gardner, Roni Neff, Armistead G. Russell, Karen C. Seto, Laurie P. Whitsel, on behalf of the American Heart Association Council on Hypertension, Council on Lifestyle and Cardiometabolic Health, Council on Peripheral Vascular Disease, Council on Lifelong Congenital Heart Disease and Heart Health in the Young
Nearly 56% of the global population lives in cities, with this number expected to increase to 6.6 billion or >70% of the world’s population by 2050. Given that cardiometabolic diseases are the leading causes of morbidity and mortality in people living in urban areas, transforming cities and urban provisioning systems (or urban systems) toward health, equity, and economic productivity can enable the
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MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States Circulation (IF 37.8) Pub Date : 2024-03-01 Logan R.J. Bailey, Darrian Bugg, Isabella M. Reichardt, C. Dessirée Ortaç, Abigail Nagle, Jagadambika Gunaje, Amy Martinson, Richard Johnson, Michael J. MacCoss, Tomoya Sakamoto, Daniel P. Kelly, Michael Regnier, Jennifer M. Davis
BACKGROUND:Discovering determinants of cardiomyocyte maturity is critical for deeply understanding the maintenance of differentiated states and potentially reawakening endogenous regenerative programs in adult mammalian hearts as a therapeutic strategy. Forced dedifferentiation paired with oncogene expression is sufficient to drive cardiac regeneration, but elucidation of endogenous developmental regulators
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Use of Artificial Intelligence in Improving Outcomes in Heart Disease: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-02-28 Antonis A. Armoundas, Sanjiv M. Narayan, Donna K. Arnett, Kayte Spector-Bagdady, Derrick A. Bennett, Leo Anthony Celi, Paul A. Friedman, Michael H. Gollob, Jennifer L. Hall, Anne E. Kwitek, Elle Lett, Bijoy K. Menon, Katherine A. Sheehan, Salah S. Al-Zaiti, on behalf of the American Heart Association Institute for Precision Cardiovascular Medicine, Council on Cardiovascular and Stroke Nursing, Council
A major focus of academia, industry, and global governmental agencies is to develop and apply artificial intelligence and other advanced analytical tools to transform health care delivery. The American Heart Association supports the creation of tools and services that would further the science and practice of precision medicine by enabling more precise approaches to cardiovascular and stroke research
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mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis Circulation (IF 37.8) Pub Date : 2024-02-27 Sarah Hoedemakers, Nicola Riccardo Pugliese, Jan Stassen, Arnaud Vanoppen, Jade Claessens, Tin Gojevic, Youri Bekhuis, Maarten Falter, Sara Moura Ferreira, Sebastiaan Dhont, Nicolò De Biase, Lavinia Del Punta, Valerio Di Fiore, Marco De Carlo, Cristina Giannini, Andrea Colli, Raluca Elena Dulgheru, Jolien Geers, Alaaddin Yilmaz, Guido Claessen, Philippe Bertrand, Steven Droogmans, Patrizio Lancellotti
BACKGROUND:Recent guidelines redefined exercise pulmonary hypertension as a mean pulmonary artery pressure/cardiac output (mPAP/CO) slope >3 mm Hg·L−1·min−1. A peak systolic pulmonary artery pressure >60 mm Hg during exercise has been associated with an increased risk of cardiovascular death, heart failure rehospitalization, and aortic valve replacement in aortic valve stenosis. The prognostic value
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Cardiogenic Shock in Older Adults: A Focus on Age-Associated Risks and Approach to Management: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-02-26 Vanessa Blumer, Manreet K. Kanwar, Christopher F. Barnett, Jennifer A. Cowger, Abdulla A. Damluji, Maryjane Farr, Sarah J. Goodlin, Jason N. Katz, Colleen K. McIlvennan, Shashank S. Sinha, Tracy Y. Wang, on behalf of the American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing, Council on
Cardiogenic shock continues to portend poor outcomes, conferring short-term mortality rates of 30% to 50% despite recent scientific advances. Age is a nonmodifiable risk factor for mortality in patients with cardiogenic shock and is often considered in the decision-making process for eligibility for various therapies. Older adults have been largely excluded from analyses of therapeutic options in patients
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Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction: A Multicenter, Randomized, Double-Blind Trial Circulation (IF 37.8) Pub Date : 2024-02-26 Yan Yan, Jincheng Guo, Xiao Wang, Guozhong Wang, Zeyuan Fan, Delu Yin, Zhifang Wang, Fuchun Zhang, Changming Tian, Wei Gong, Jiamin Liu, Jiapeng Lu, Yongjun Li, Changsheng Ma, Eric Vicaut, Gilles Montalescot, Shaoping Nie, on behalf of the RIGHT Investigators
BACKGROUND:Postprocedural anticoagulation (PPA) is frequently administered after primary percutaneous coronary intervention in ST-segment–elevation myocardial infarction, although no conclusive data support this practice.METHODS:The RIGHT trial (Comparison of Anticoagulation Prolongation vs no Anticoagulation in STEMI Patients After Primary PCI) was an investigator-initiated, multicenter, randomized
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Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism Circulation (IF 37.8) Pub Date : 2024-02-23 Sheng Zhang, Yunkai Zhang, Xuewen Duan, Bo Wang, Zhenzhen Zhan
BACKGROUND:Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound healing. Metabolic adaptation orchestrates the phenotypic transition of macrophages; however, the precise mechanisms governing metabolic reprogramming of cardiac reparative
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Neurodevelopmental Outcomes for Individuals With Congenital Heart Disease: Updates in Neuroprotection, Risk-Stratification, Evaluation, and Management: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-02-22 Erica Sood, Jane W. Newburger, Julia S. Anixt, Adam R. Cassidy, Jamie L. Jackson, Richard A. Jonas, Amy J. Lisanti, Keila N. Lopez, Shabnam Peyvandi, Bradley S. Marino, on behalf of the American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young and the Council on Cardiovascular and Stroke Nursing
Over the past decade, new research has advanced scientific knowledge of neurodevelopmental trajectories, factors that increase neurodevelopmental risk, and neuroprotective strategies for individuals with congenital heart disease. In addition, best practices for evaluation and management of developmental delays and disorders in this high-risk patient population have been formulated based on literature
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Addressing Barriers to Entry and Retention of Women in Interventional Vascular Specialties With Proposed Solutions: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-02-20 S. Elissa Altin, Mimmie Kwong, Naomi M. Hamburg, Mark A. Creager, Subhash Banerjee, Lola Oladini, Marabel D. Schneider, Jean Marie Ruddy, on behalf of the American Heart Association Council on Peripheral Vascular Disease, Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, and Stroke Council
Representation of women in interventional vascular fields (interventional cardiology, interventional radiology, and vascular surgery) lags behind that in other specialties. With women representing half of all medical school graduates, encouraging parity of women in these fields needs to start in medical school. Barriers to pursuing careers in vascular intervention include insufficient exposure during
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FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System Circulation (IF 37.8) Pub Date : 2024-02-16 Bowen Li, Fangfang Liu, Xihui Chen, Tangdong Chen, Juan Zhang, Yifeng Liu, Yan Yao, Weihong Hu, Mengjie Zhang, Bo Wang, Liwen Liu, Kun Chen, Yuanming Wu
BACKGROUND:Hypertrophic cardiomyopathy (HCM) is a common heritable myocardiopathy. Although HCM has been reported to be associated with many variants of genes involved in sarcomeric protein biomechanics, pathogenic genes have not been identified in patients with partial HCM. FARS2 (the mitochondrial phenylalanyl-tRNA synthetase), a type of mitochondrial aminoacyl-tRNA synthetase, plays a role in the
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Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation Circulation (IF 37.8) Pub Date : 2024-02-15 Amy Erica Lin, Aneesh C. Bapat, Ling Xiao, Abhishek Niroula, Jianchuan Ye, Waihay J. Wong, Mridul Agrawal, Christopher J. Farady, Andreas Boettcher, Christopher B. Hergott, Marie McConkey, Patricio Flores-Bringas, Veronica Shkolnik, Alexander G. Bick, David Milan, Pradeep Natarajan, Peter Libby, Patrick T. Ellinor, Benjamin L. Ebert
BACKGROUND:Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the risk of myocardial infarction and heart failure, the influence of CHIP in cardiac arrhythmias, such as atrial fibrillation (AF), is less explored.METHODS:CHIP prevalence
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Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells Circulation (IF 37.8) Pub Date : 2024-02-15 Ziwen Cai, Miaomiao Zhu, Li Xu, Yue Wang, Yin Xu, Wai Yen Yim, Hong Cao, Ruikang Guo, Xiang Qiu, Ximiao He, Jiawei Shi, Weihua Qiao, Nianguo Dong
BACKGROUND:A main obstacle in current valvular heart disease research is the lack of high-quality homogeneous functional heart valve cells. Human induced pluripotent stem cells (hiPSCs)-derived heart valve cells may help with this dilemma. However, there are no well-established protocols to induce hiPSCs to differentiate into functional heart valve cells, and the networks that mediate the differentiation
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S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages Circulation (IF 37.8) Pub Date : 2024-02-15 Yan Zhang, Hao Zhang, Shuang Zhao, Zhenhua Qi, Yiwei He, Xuhong Zhang, Wencheng Wu, Ke Yan, Lulu Hu, Shixiu Sun, Xinlong Tang, Qing Zhou, Feng Chen, Aihua Gu, Liansheng Wang, Zhiren Zhang, Bo Yu, Dongjin Wang, Yi Han, Liping Xie, Yong Ji
BACKGROUND:S-Nitrosylation (SNO), a prototypic redox-based posttranslational modification, is involved in cardiovascular disease. Aortic aneurysm and dissection are high-risk cardiovascular diseases without an effective cure. The aim of this study was to determine the role of SNO of Septin2 in macrophages in aortic aneurysm and dissection.METHODS:Biotin-switch assay combined with liquid chromatography–tandem
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Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification Circulation (IF 37.8) Pub Date : 2024-02-13 Xiaoxuan Zhai, Shengchuan Cao, Jiali Wang, Bao Qiao, Xuehao Liu, Rui Hua, Menglin Zhao, Shukun Sun, Yu Han, Shuo Wu, Jiaojiao Pang, Qiuhuan Yuan, Bailu Wang, Feng Xu, Shujian Wei, Yuguo Chen
BACKGROUND:Vascular calcification, which is characterized by calcium deposition in arterial walls and the osteochondrogenic differentiation of vascular smooth muscle cells, is an actively regulated process that involves complex mechanisms. Vascular calcification is associated with increased cardiovascular adverse events. The role of 4-hydroxynonenal (4-HNE), which is the most abundant stable product
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The American Heart Association at 100: A Century of Scientific Progress and the Future of Cardiovascular Science: A Presidential Advisory From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-02-12 Mitchell S.V. Elkind, Donna K. Arnett, Ivor J. Benjamin, Robert H. Eckel, Augustus O. Grant, Steven R. Houser, Alice K. Jacobs, Daniel W. Jones, Rose Marie Robertson, Ralph L. Sacco, Sidney C. Smith , Jr, Myron L. Weisfeldt, Joseph C. Wu, Mariell Jessup
In 1924, the founders of the American Heart Association (AHA) envisioned an international society focused on the heart and aimed at facilitating research, disseminating information, increasing public awareness, and developing public health policy related to heart disease. This presidential advisory provides a comprehensive review of the past century of cardiovascular and stroke science, with a focus
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Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure Circulation (IF 37.8) Pub Date : 2024-02-08 Yunqi Jiang, Jinge Gu, Xiaodou Niu, Jiaojiao Hu, Yongzhen Zhang, Dan Li, Yida Tang, Cong Liu, Zijian Li
BACKGROUND:Heart failure (HF), which is the terminal stage of many cardiovascular diseases, is associated with low survival rates and a severe financial burden. The mechanisms, especially the molecular mechanism combined with new theories, underlying the pathogenesis of HF remain elusive. We demonstrate that phosphorylation-regulated dynamic liquid–liquid phase separation of HIP-55 (hematopoietic progenitor
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Pediatric ECG-Based Deep Learning to Predict Left Ventricular Dysfunction and Remodeling Circulation (IF 37.8) Pub Date : 2024-02-05 Joshua Mayourian, William G. La Cava, Akhil Vaid, Girish N. Nadkarni, Sunil J. Ghelani, Rebekah Mannix, Tal Geva, Audrey Dionne, Mark E. Alexander, Son Q. Duong, John K. Triedman
BACKGROUND:Artificial intelligence–enhanced ECG analysis shows promise to detect ventricular dysfunction and remodeling in adult populations. However, its application to pediatric populations remains underexplored.METHODS:A convolutional neural network was trained on paired ECG–echocardiograms (≤2 days apart) from patients ≤18 years of age without major congenital heart disease to detect human expert–classified
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Efficacy and Safety of Non–Vitamin-K Antagonist Oral Anticoagulants Versus Warfarin Across the Spectrum of Body Mass Index and Body Weight: An Individual Patient Data Meta-Analysis of Four Randomized Clinical Trials of 58 464 Patients With Atrial Fibrillation Circulation (IF 37.8) Pub Date : 2024-01-24 Siddharth M. Patel, Eugene Braunwald, Jan Steffel, Giuseppe Boriani, Michael G. Palazzolo, Elliott M. Antman, Erin A. Bohula, Anthony P. Carnicelli, Stuart J. Connolly, John Eikelboom, Baris Gencer, Christopher B. Granger, David A. Morrow, Manesh R. Patel, Lars Wallentin, Christian T. Ruff, Robert P. Giugliano, on behalf of the COMBINE AF (A Collaboration Between Multiple Institutions to Better Investigate
BACKGROUND:The efficacy and safety of non–vitamin-K antagonist oral anticoagulants (NOACs) across the spectrum of body mass index (BMI) and body weight (BW) remain uncertain.METHODS:We analyzed data from COMBINE AF (A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant Use in Atrial Fibrillation), which pooled patient-level data from the 4 pivotal
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AVCAPIR: A Novel Procalcific PIWI-Interacting RNA in Calcific Aortic Valve Disease Circulation (IF 37.8) Pub Date : 2024-01-23 Dong Han, Tingwen Zhou, Lifu Li, Yan Ma, Shiqi Chen, Chunguang Yang, Ning Ma, Moshi Song, Shaoshao Zhang, Jie Wu, Feng Cao, Yongjun Wang
BACKGROUND:Calcification of the aortic valve leads to increased leaflet stiffness and consequently results in the development of calcific aortic valve disease (CAVD). However, the underlying molecular and cellular mechanisms of calcification remain unclear. Here, we identified a novel aortic valve calcification-associated PIWI-interacting RNA (piRNA; AVCAPIR) that increases valvular calcification and
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Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation Circulation (IF 37.8) Pub Date : 2024-01-18 Lija Swain, Shreyas Bhave, Xiaoying Qiao, Lara Reyelt, Kay Everett, Junya Awata, Rahul Raghav, Sarah N. Powers, Genya Sunagawa, Peter S. Natov, Elena Mahmoudi, Mary Warner, Greg Couper, Masa Kawabori, Satoshi Miyashita, Tejasvi Aryaputra, Gordon S. Huggins, Michael T. Chin, Navin K. Kapur
BACKGROUND:Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Tafazzin is an enzyme that is required for cardiolipin maturation. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) use to provide hemodynamic support for acute myocardial infarction has grown exponentially
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Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1 Circulation (IF 37.8) Pub Date : 2024-01-15 Tiffany A. Garbutt, Zhenhua Wang, Haofei Wang, Hong Ma, Hongmei Ruan, Yanhan Dong, Yifang Xie, Lianmei Tan, Ranan Phookan, Joy Stouffer, Vasanth Vedantham, Yuchen Yang, Li Qian, Jiandong Liu
BACKGROUND:During the neonatal stage, the cardiomyocyte undergoes a constellation of molecular, cytoarchitectural, and functional changes known collectively as cardiomyocyte maturation to increase myocardial contractility and cardiac output. Despite the importance of cardiomyocyte maturation, the molecular mechanisms governing this critical process remain largely unexplored.METHODS:We leveraged an
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Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex Circulation (IF 37.8) Pub Date : 2024-01-12 Chen Xu, Ge Zhang, Xinjian Wang, Xiaozhi Huang, Jiayin Zhang, Shuxian Han, Jinxi Wang, Duane D. Hall, Ruoqing Xu, Feng He, Xing Chang, Fudi Wang, Wenjun Xie, Zhichao Wu, Long-Sheng Song, Peidong Han
BACKGROUND:Cardiac transverse tubules (T-tubules) are anchored to sarcomeric Z-discs by costameres to establish a regular spaced pattern. One of the major components of costameres is the dystrophin-glycoprotein complex (DGC). Nevertheless, how the assembly of the DGC coordinates with the formation and maintenance of T-tubules under physiological and pathological conditions remains unclear.METHODS:Given
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ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension Circulation (IF 37.8) Pub Date : 2024-01-12 Jin-Song Bian, Jingyu Chen, Junting Zhang, Jianxin Tan, Yuan Chen, Xusheng Yang, Yiying Li, Lin Deng, Rongchang Chen, Xiaowei Nie
BACKGROUND:Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression of pulmonary hypertension (PH). ErbB3 (human epidermal growth factor receptor 3), also recognized as HER3, is a member of the ErbB family of receptor tyrosine kinases.METHODS:Microarray
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A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network Circulation (IF 37.8) Pub Date : 2024-01-08 Michael T. Broman, Rangarajan D. Nadadur, Carlos Perez-Cervantes, Ozanna Burnicka-Turek, Sonja Lazarevic, Anna Gams, Brigitte Laforest, Jeffrey D. Steimle, Sabrina Iddir, Zhezhen Wang, Linsin Smith, Stefan R. Mazurek, Harold E. Olivey, Pingzhu Zhou, Margaret Gadek, Kaitlyn M. Shen, Zoheb Khan, Joshua W.M. Theisen, Xinan H. Yang, Kohta Ikegami, Igor R. Efimov, William T. Pu, Christopher R. Weber, Elizabeth
BACKGROUND:The relationship between heart failure (HF) and atrial fibrillation (AF) is clear, with up to half of patients with HF progressing to AF. The pathophysiological basis of AF in the context of HF is presumed to result from atrial remodeling. Upregulation of the transcription factor FOG2 (friend of GATA2; encoded by ZFPM2) is observed in human ventricles during HF and causes HF in mice.METHODS:FOG2
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Metabolic Communication by SGLT2 Inhibition Circulation (IF 37.8) Pub Date : 2023-12-28 Anja M. Billing, Young Chul Kim, Søren Gullaksen, Benedikt Schrage, Janice Raabe, Arvid Hutzfeldt, Fatih Demir, Elina Kovalenko, Moritz Lassé, Aurelien Dugourd, Robin Fallegger, Birgit Klampe, Johannes Jaegers, Qing Li, Olha Kravtsova, Maria Crespo-Masip, Amelia Palermo, Robert A. Fenton, Elion Hoxha, Stefan Blankenberg, Paulus Kirchhof, Tobias B. Huber, Esben Laugesen, Tanja Zeller, Maria Chrysopoulou
BACKGROUND:SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect the kidneys and heart, but the underlying mechanism remains poorly understood.METHODS:To gain insights on primary effects of SGLT2i that are not confounded by pathophysiologic processes or are secondary to improvement by SGLT2i, we performed an in-depth proteomics, phosphoproteomics, and metabolomics analysis by integrating
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INO80-Dependent Remodeling of Transcriptional Regulatory Network Underlies the Progression of Heart Failure Circulation (IF 37.8) Pub Date : 2023-12-28 Zongna Ren, Wanqing Zhao, Dandan Li, Peng Yu, Lin Mao, Quanyi Zhao, Luyan Yao, Xuelin Zhang, Yandan Liu, Bingying Zhou, Li Wang
BACKGROUND:Progressive remodeling of cardiac gene expression underlies decline in cardiac function, eventually leading to heart failure. However, the major determinants of transcriptional network switching from normal to failed hearts remain to be determined.METHODS:In this study, we integrated human samples, genetic mouse models, and genomic approaches, including bulk RNA sequencing, single-cell RNA
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Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension Circulation (IF 37.8) Pub Date : 2023-12-22 William R. Reay, Erin Clarke, Shaun Eslick, Carlos Riveros, Elizabeth G. Holliday, Mark A. McEvoy, Roseanne Peel, Stephen Hancock, Rodney J. Scott, John R. Attia, Clare E. Collins, Murray J. Cairns
BACKGROUND:Hypertension is a key risk factor for major adverse cardiovascular events but remains difficult to treat in many individuals. Dietary interventions are an effective approach to lower blood pressure (BP) but are not equally effective across all individuals. BP is heritable, and genetics may be a useful tool to overcome treatment response heterogeneity. We investigated whether the genetics
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Induced Endothelial Cell CycleArrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia Circulation (IF 37.8) Pub Date : 2023-12-21 Gael Genet, Nafiisha Genet, Umadevi Paila, Shelby R. Cain, Aleksandra Cwiek, Nicholas W. Chavkin, Vlad Serbulea, Agnès Figueras, Pau Cerdà, Stephanie P. McDonnell, Danya Sankaranarayanan, Mahalia Huba, Elizabeth A. Nelson, Antoni Riera-Mestre, Karen K. Hirschi
BACKGROUND:Distinct endothelial cell cycle states (early G1 versus late G1) provide different “windows of opportunity” to enable the differential expression of genes that regulate venous versus arterial specification, respectively. Endothelial cell cycle control and arteriovenous identities are disrupted in vascular malformations including arteriovenous shunts, the hallmark of hereditary hemorrhagic
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Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy Circulation (IF 37.8) Pub Date : 2023-12-18 Guido Claessen, Ruben De Bosscher, Kristel Janssens, Paul Young, Christophe Dausin, Mathias Claeys, Piet Claus, Kaatje Goetschalckx, Jan Bogaert, Amy M. Mitchell, Michael D. Flannery, Adrian D. Elliott, Chenglong Yu, Olivier Ghekiere, Tomas Robyns, Caroline M. Van De Heyning, Prashanthan Sanders, Jonathan M. Kalman, Monique Ohanian, Magdalena Soka, Emma Rath, Eleni Giannoulatou, Renee Johnson, Paul
BACKGROUND:Exercise-induced cardiac remodeling can be profound, resulting in clinical overlap with dilated cardiomyopathy, yet the significance of reduced ejection fraction (EF) in athletes is unclear. The aim is to assess the prevalence, clinical consequences, and genetic predisposition of reduced EF in athletes.METHODS:Young endurance athletes were recruited from elite training programs and underwent
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HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells Circulation (IF 37.8) Pub Date : 2023-12-15 Ian A. Tamargo, Kyung In Baek, Chenbo Xu, Dong Won Kang, Yerin Kim, Aitor Andueza, Darian Williams, Catherine Demos, Nicolas Villa-Roel, Sandeep Kumar, Christian Park, Rachel Choi, Janie Johnson, Seowon Chang, Paul Kim, Sheryl Tan, Kiyoung Jeong, Shoutaro Tsuji, Hanjoong Jo
BACKGROUND:Atherosclerosis preferentially occurs in arterial regions of disturbed blood flow, and stable flow (s-flow) protects against atherosclerosis by incompletely understood mechanisms.METHODS AND RESULTS:Heart-of-glass 1 (HEG1) was identified from a single-cell RNA-sequencing study as an s-flow–induced endothelial gene, which we validated in vivo and in vitro. S-flow stimulated HEG1 protein translocation
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Effect of Dapagliflozin Versus Placebo on Symptoms and 6-Minute Walk Distance in Patients With Heart Failure: The DETERMINE Randomized Clinical Trials Circulation (IF 37.8) Pub Date : 2023-12-07 John J.V. McMurray, Kieran F. Docherty, Rudolf A. de Boer, Ann Hammarstedt, Dalane W. Kitzman, Mikhail N. Kosiborod, Anna Maria Langkilde, Barry Reicher, Michele Senni, Sanjiv J. Shah, Ulrica Wilderäng, Subodh Verma, Scott D. Solomon
BACKGROUND:Sodium-glucose cotransporter 2 inhibitors reduce the risk of worsening heart failure (HF) and cardiovascular death in patients with HF irrespective of left ventricular ejection fraction. It is important to determine whether therapies for HF improve symptoms and functional capacity.METHODS:The DETERMINE (Dapagliflozin Effect on Exercise Capacity Using a 6-Minute Walk Test in Patients With
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Perspective on ACC/AHA/ACCP/HRS Guidelines for the Management of Atrial Fibrillation. Circulation (IF 37.8) Pub Date : 2023-11-30 Angela Khidhir,Anne B Curtis
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Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study. Circulation (IF 37.8) Pub Date : 2023-11-30 Gregory L Hundemer,Mohsen Agharazii,François Madore,Anand Vaidya,Jenifer M Brown,Alexander A Leung,Gregory A Kline,Eric Larose,Marie-Eve Piché,Andrew M Crean,Julie L V Shaw,Tim Ramsay,Bernhard Hametner,Siegfried Wassertheurer,Manish M Sood,Swapnil Hiremath,Marcel Ruzicka,Rémi Goupil
BACKGROUND Primary aldosteronism, characterized by overt renin-independent aldosterone production, is a common but underrecognized form of hypertension and cardiovascular disease. Growing evidence suggests that milder and subclinical forms of primary aldosteronism are highly prevalent, yet their contribution to cardiovascular disease is not well characterized. METHODS This prospective study included
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Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis Circulation (IF 37.8) Pub Date : 2023-11-29 Fangni Zhang, Kan Li, Wenhui Zhang, Ziyan Zhao, Fangyuan Chang, Jie Du, Xu Zhang, Kaiwen Bao, Chunyong Zhang, Lei Shi, Zongwei Liu, Xiangchen Dai, Chen Chen, Dao Wen Wang, Zhong Xian, Hongfeng Jiang, Ding Ai
BACKGROUND:Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition, but approved medical therapies to prevent AAA progression and rupture are currently lacking. Sphingolipid metabolism disorders are associated with the occurrence and development of AAA. It has been discovered that ganglioside GM3, a sialic acid–containing type of glycosphingolipid, plays a protective role
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Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. Circulation (IF 37.8) Pub Date : 2023-11-29 Ying Lin,Qifan Yang,Xiaoping Lin,Xianbao Liu,Yi Qian,Dilin Xu,Naifang Cao,Ximeng Han,Yanqing Zhu,Wangxing Hu,Xiaopeng He,Zhengyang Yu,Xiangmin Kong,Lianlian Zhu,Zhiwei Zhong,Kai Liu,Bin Zhou,Yidong Wang,Jinrong Peng,Wei Zhu,Jian'an Wang
BACKGROUND A better understanding of the molecular mechanism of aortic valve development and bicuspid aortic valve (BAV) formation would significantly improve and optimize the therapeutic strategy for BAV treatment. Over the past decade, the genes involved in aortic valve development and BAV formation have been increasingly recognized. On the other hand, a disintegrin and metalloproteinase with thrombospondin
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Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events. Circulation (IF 37.8) Pub Date : 2023-11-28 Feitong Wu,Markus Juonala,David R Jacobs,Stephen R Daniels,Mika Kähönen,Jessica G Woo,Alan R Sinaiko,Jorma S A Viikari,Lydia A Bazzano,Trudy L Burns,Julia Steinberger,Elaine M Urbina,Alison J Venn,Olli T Raitakari,Terence Dwyer,Costan G Magnussen
BACKGROUND Although low-density lipoprotein cholesterol (LDL-C) remains the primary cholesterol target in clinical practice in children and adults, non-high-density lipoprotein cholesterol (non-HDL-C) has been suggested as a more accurate measure of atherosclerotic cardiovascular disease (ASCVD) risk. We examined the associations of childhood non-HDL-C and LDL-C levels with adult ASCVD events and determined
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Letter by Li et al Regarding Article, "SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension". Circulation (IF 37.8) Pub Date : 2023-11-27 Guling Li,Hui Chen,Chuanli Ren
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Groups Urge a Return to LDL-C Monitoring as a Quality Metric. Circulation (IF 37.8) Pub Date : 2023-11-27 Bridget M Kuehn
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Expanding the Definition of Worsening Heart Failure and Recognizing the Importance of Outpatient Escalation of Oral Diuretics. Circulation (IF 37.8) Pub Date : 2023-11-27 Stephen J Greene,Javed Butler
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Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy. Circulation (IF 37.8) Pub Date : 2023-11-27 Ethan J Rowin,Mark S Link,Martin S Maron,Barry J Maron
Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM) with clinical and subclinical episodes occurring in nearly one-half of patients. AF in HCM historically has been characterized as a decisive disease complication associated with substantial risk for thromboembolic stroke and increased morbidity and mortality. However, there have been many advances
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Response by Walters et al to Letter Regarding Article, "SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension". Circulation (IF 37.8) Pub Date : 2023-11-27 Rachel Walters,Eleni Vasilaki,Martin R Wilkins,Lan Zhao,Christopher J Rhodes
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Making the Right Diagnosis: Slowly but Surely. Circulation (IF 37.8) Pub Date : 2023-11-27 Parag R Gajendragadkar,Claire A Martin,Rohan S Wijesurendra
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USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart. Circulation (IF 37.8) Pub Date : 2023-11-23 Sai-Yang Xie,Shi-Qiang Liu,Tong Zhang,Wen-Ke Shi,Yun Xing,Wen-Xi Fang,Min Zhang,Meng-Ya Chen,Si-Chi Xu,Meng-Qi Fan,Lan-Lan Li,Heng Zhang,Nan Zhao,Zhao-Xiang Zeng,Si Chen,Xiao-Feng Zeng,Wei Deng,Qi-Zhu Tang
BACKGROUND The majority of people with diabetes are susceptible to cardiac dysfunction and heart failure, and conventional drug therapy cannot correct diabetic cardiomyopathy progression. Herein, we assessed the potential role and therapeutic value of USP28 (ubiquitin-specific protease 28) on the metabolic vulnerability of diabetic cardiomyopathy. METHODS The type 2 diabetes mouse model was established
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An Aspirin-Free Versus Dual Antiplatelet Strategy for Coronary Stenting: STOPDAPT-3 Randomized Trial. Circulation (IF 37.8) Pub Date : 2023-11-23 Masahiro Natsuaki,Hirotoshi Watanabe,Takeshi Morimoto,Ko Yamamoto,Yuki Obayashi,Ryusuke Nishikawa,Kenji Ando,Takenori Domei,Satoru Suwa,Manabu Ogita,Tsuyoshi Isawa,Hiroyuki Takenaka,Takashi Yamamoto,Tetsuya Ishikawa,Itaru Hisauchi,Kohei Wakabayashi,Yuko Onishi,Kiyoshi Hibi,Kazuya Kawai,Ruka Yoshida,Hiroshi Suzuki,Gaku Nakazawa,Takanori Kusuyama,Itsuro Morishima,Koh Ono,Takeshi Kimura
BACKGROUND Bleeding rates on dual antiplatelet therapy (DAPT) within 1 month after percutaneous coronary intervention (PCI) remain high in clinical practice, particularly in patients with acute coronary syndrome or high bleeding risk. Aspirin-free strategy might result in lower bleeding early after PCI without increasing cardiovascular events, but its efficacy and safety have not yet been proven in
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Response by de Bakker et al to Letter Regarding Article, "Sex Differences In Cardiac Troponin Trajectories Over the Life Course". Circulation (IF 37.8) Pub Date : 2023-11-20 Marie de Bakker,Atul Anand,Nicholas L Mills,Dorien M Kimenai
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Atrioventricular Block: Does This Patient Require a Pacemaker? Circulation (IF 37.8) Pub Date : 2023-11-20 Esteban González-Torrecilla,Raquel Luna López,Pablo Ávila Alonso
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Clinical Course of Isolated Distal Venous Thromboembolism in Patients With Active Cancer in a Nation With an Overall Low Risk of Thrombosis. Circulation (IF 37.8) Pub Date : 2023-11-20 Shinya Goto,Shinichi Goto
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Improved Factor Combination for In Vivo Reprogramming of Cardiac Myofibroblast to Cardiomyocyte-Like Cell With Dual Recombinase Tracing. Circulation (IF 37.8) Pub Date : 2023-11-20 Jingdong Wu,Hong Zhao,Yanmeng Tao,Chunyan Yang,Yang Yang,Bin Zhou,Yang Zhao
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Letter by Esau Regarding Article, "Sex Differences in Cardiac Troponin Trajectories Over the Life Course". Circulation (IF 37.8) Pub Date : 2023-11-20 Daniel Esau
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High-Sensitivity Cardiac Troponin I Enhances Preeclampsia Prediction Beyond Maternal Factors and the sFlt-1/PlGF Ratio. Circulation (IF 37.8) Pub Date : 2023-11-20 L Bacmeister,A Goßling,A Buellesbach,A Birukov,J E Myers,S T Thomas,S Lee,M S Andersen,J S Jorgensen,A Diemert,S M Blois,P C Arck,K Hecher,F Herse,S Blankenberg,R Dechend,D Westermann,T Zeller
BACKGROUND Preeclampsia shares numerous risk factors with cardiovascular diseases. Here, we aimed to assess the potential utility of high-sensitivity cardiac troponin I (hs-cTnI) values during pregnancy in predicting preeclampsia occurrence. METHODS This study measured hs-cTnI levels in 3721 blood samples of 2245 pregnant women from 4 international, prospective cohorts. Three analytical approaches
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Long-Term Mortality in Patients With Severe Hypercholesterolemia Phenotype From a Racial and Ethnically Diverse US Cohort. Circulation (IF 37.8) Pub Date : 2023-11-16 Jeremy Miles,Andrea Scotti,Francesco Castagna,Toshiki Kuno,Pier Pasquale Leone,Augustin Coisne,Sebastian Ludwig,Carl J Lavie,Parag H Joshi,Azeem Latib,Mario J Garcia,Carlos J Rodriguez,Michael D Shapiro,Salim S Virani,Leandro Slipczuk
BACKGROUND Tools for mortality prediction in patients with the severe hypercholesterolemia phenotype (low-density lipoprotein cholesterol ≥190 mg/dL) are limited and restricted to specific racial and ethnic cohorts. We sought to evaluate the predictors of long-term mortality in a large racially and ethnically diverse US patient cohort with low-density lipoprotein cholesterol ≥190 mg/dL. METHODS We
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Stimulates Short-Chain Dehydrogenase/Reductase Proteins to Alleviate Heart Failure Independent of Mitochondrial Protein Deacetylation. Circulation (IF 37.8) Pub Date : 2023-11-15 Matthew A Walker,Hongye Chen,Aprajita Yadav,Julia Ritterhoff,Outi Villet,Tim McMillen,Yuliang Wang,Hayley Purcell,Danijel Djukovic,Daniel Raftery,Nina Isoherranen,Rong Tian
BACKGROUND Strategies to increase cellular NAD+ (oxidized nicotinamide adenine dinucleotide) level have prevented cardiac dysfunction in multiple models of heart failure, but molecular mechanisms remain unclear. Little is known about the benefits of NAD+-based therapies in failing hearts after the symptoms of heart failure have appeared. Most pretreatment regimens suggested mechanisms involving activation