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Induced Cytokinesis Generates Highly Proliferative Mononuclear Cardiomyocytes at the Expense of Contractility. Circulation (IF 35.5) Pub Date : 2025-02-06 Nicholas T Lam,Ngoc Uyen Nhi Nguyen,Waleed M Elhelaly,Ching-Cheng Hsu,Ivan Menendez-Montes,Feng Xiao,Shah R Ali,Nelson Vo,Nathan Briard,Lobna El-Feky,Qamar M Omari,Alisson C Cardoso,Yan Liu,Mahmoud Salama Ahmed,Shujuan Li,Suwannee Thet,Chao Xing,Lior Zangi,Hesham A Sadek
BACKGROUND Cytokinesis is the last step in the eukaryotic cell cycle, which physically separates a mitotic cell into 2 daughter cells. A few days after birth in mouse cardiomyocytes, DNA synthesis occurs without cytokinesis, leading to the majority of cardiomyocytes becoming binucleated instead of generating 2 daughter cells with 1 nucleus each. This results in cell cycle arrest of cardiomyocytes,
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Stepwise Provisional Versus Systematic Dual-Stent Strategies for Treatment of True Left Main Coronary Bifurcation Lesions. Circulation (IF 35.5) Pub Date : 2025-02-05 Sandeep Arunothayaraj,Mohaned Egred,Adrian P Banning,Philippe Brunel,Miroslaw Ferenc,Thomas Hovasse,Adrian Wlodarczak,Manuel Pan,Thomas Schmitz,Marc Silvestri,Andreis Erglis,Evgeny Kretov,Jens Flensted Lassen,Alaide Chieffo,Thierry Lefèvre,Francesco Burzotta,James Cockburn,Olivier Darremont,Goran Stankovic,Marie-Claude Morice,Yves Louvard,David Hildick-Smith
BACKGROUND The optimal coronary stenting technique for true left main bifurcation lesions is uncertain. EBC MAIN (European Bifurcation Club Left Main Trial) aimed to evaluate clinical outcomes of a stepwise provisional strategy compared with a systematic dual-stent approach. METHODS EBC MAIN was a randomized, investigator-initiated, open-label, multicenter, parallel-group trial conducted across 35
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CD4+ T Cells Expressing Viral Proteins Induce HIV-Associated Endothelial Dysfunction and Hypertension Through Interleukin 1α-Mediated Increases in Endothelial NADPH Oxidase 1. Circulation (IF 35.5) Pub Date : 2025-02-05 Taylor C Kress,Candee T Barris,Laszlo Kovacs,Beryl N Khakina,Coleton R Jordan,Thiago Bruder-Nascimento,David W Stepp,Rodger MacArthur,Vijay S Patel,Jie Chen,Rafal Pacholczyk,Simone Kennard,Eric J Belin de Chantemèle
BACKGROUND Although combination antiretroviral therapy has increased life expectancy in people living with HIV, it has led to a marked increase in the prevalence of hypertension, the cause of which is unknown. Despite combination antiretroviral therapy, HIV-derived proteins remain expressed and produced by CD4+ T lymphocytes in people living with HIV. However, their contribution to HIV-associated hypertension
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Efficacy of Irbesartan in Celiprolol-Treated Patients With Vascular Ehlers-Danlos Syndrome. Circulation (IF 35.5) Pub Date : 2025-02-05 Xavier Jeunemaitre,Elie Mousseaux,Michael Frank,Salma Adham,Francesca Pitocco,Clarisse Billon,Molka Ben Yakhlef,Mohamed El Hachmi,Alessandra Bura-Rivière,François-Xavier Lapébie,Claire Le Hello,Damien Laneelle,Christophe Seinturier,Klaus Dieterich,Marc Lambert,Sophie Dupuis-Girod,Stéphane Zuily,Laurence Bal-Theoleyre,Carine Boulon,Pierrick Henneton,Estelle Lu,Nicolas Denarié,Pierre Boutouyrie,Tristan
BACKGROUND Vascular Ehlers-Danlos syndrome is a rare genetic disorder characterized by defective type III collagen and a high risk of arterial morbidity and mortality. Several cardiovascular drugs are used for treatment, including celiprolol, but no controlled trial in this condition has been conducted to date. We hypothesized the benefit of the addition of an angiotensin II receptor blocker. METHODS
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A Win for Clinical Evidence: The First Head-to-Head Trial of Interventional Strategies for the Treatment of Pulmonary Embolism. Circulation (IF 35.5) Pub Date : 2025-02-03 Sunil V Rao,J Antonio T Gutierrez
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Letter by Wang and Peng Regarding Article, "Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart". Circulation (IF 35.5) Pub Date : 2025-02-03 Xiang Wang,Xiaoping Peng
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Measure Apolipoprotein B If We Believe What We Say About Precision Medicine. Circulation (IF 35.5) Pub Date : 2025-02-03 Anna Wolska,Donald M Lloyd-Jones,Alan T Remaley
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Risk of Atrial Fibrillation After Hemorrhagic Stroke: A Nationwide Cohort Study With Propensity Score Matching. Circulation (IF 35.5) Pub Date : 2025-02-03 Jihun Kang,Jung Eun Yoo,Byeoung-Jun Jeon,Sung Il Im,Bongseong Kim,Won Hyuk Chang,Kyungdo Han,Dong Wook Shin
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Response by Grune and Nahrendorf to Letter Regarding Article, "Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart". Circulation (IF 35.5) Pub Date : 2025-02-03 Jana Grune,Matthias Nahrendorf
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Systematic Review, Meta-Analysis, and Population Study to Determine the Biologic Sex Ratio in Dilated Cardiomyopathy. Circulation (IF 35.5) Pub Date : 2025-02-03 Natalie Bergan,Ishika Prachee,Lara Curran,Kathryn A McGurk,Chang Lu,Antonio de Marvao,Wenjia Bai,Brian P Halliday,John Gregson,Declan P O'Regan,James S Ware,Upasana Tayal
BACKGROUND Dilated cardiomyopathy (DCM) appears to be diagnosed twice as often in male than in female patients. This could be attributed to underdiagnosis in female patients or sex differences in susceptibility. Up to 30% of cases have an autosomal dominant monogenic cause, where equal sex prevalence would be expected. The aim of this systematic review, meta-analysis, and population study was to assess
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Long-Term Prognostic Implications of Non-Culprit Lesions in Patients Presenting With an Acute Myocardial Infarction: Is It the Angiographic Stenosis Severity or the Underlying High-Risk Morphology? Circulation (IF 35.5) Pub Date : 2025-01-31 Jiannan Dai,Jiawei Zhao,Xueming Xu,Yuzhu Chen,Sibo Sun,Shuang Li,Lina Cui,Yini Wang,Lulu Li,Ruirong Guo,Dongxu Huang,Xianqin Ma,Rui Zhao,Huai Yu,Tao Chen,Jinfeng Tan,Xiaohui Liu,Senqing Jiang,Jingbo Hou,Chao Fang,Gary S Mintz,Bo Yu
BACKGROUND Patients with acute myocardial infarction and angiographically obstructive non-culprit lesions are at high risk for recurrent major adverse cardiac events (MACEs). However, it remains largely unknown whether events are due to stenosis severity or due to the underlying high-risk lesion morphology. METHODS Between January 2017 and December 2021, 1312 patients with acute myocardial infarction
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Aspirin Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis Among Patients With Post-Thrombotic Syndrome: The Multicenter, Multinational, Randomized, Open-label ARIVA Trial. Circulation (IF 35.5) Pub Date : 2025-01-28 Stefano Barco,Houman Jalaie,Tim Sebastian,Simon Wolf,Riccardo M Fumagalli,Michael Lichtenberg,Thomas Zeller,Christian Erbel,Oliver Schlager,Nils Kucher
BACKGROUND In patients with post-thrombotic syndrome (PTS), stent recanalization of iliofemoral veins or the inferior vena cava can restore venous patency and improve functional outcomes. The risk of stent thrombosis is particularly increased during the first 6 months after intervention. The ARIVA trial tested whether daily aspirin 100 mg plus rivaroxaban 20 mg is superior to rivaroxaban 20 mg alone
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Cardiorespiratory Fitness Assessment in Stem Cell Transplant Recipients: Getting to the Heart of the Problem. Circulation (IF 35.5) Pub Date : 2025-01-27 Justin M Canada
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Kidney Decline Predicts Worse Heart Failure Outcomes. Circulation (IF 35.5) Pub Date : 2025-01-27 Bridget M Kuehn
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SLICE-CEA CardioLink-8: A Randomized Trial of Evolocumab on Carotid Artery Atherosclerotic Plaque Characteristics in Asymptomatic High-Risk Carotid Stenosis. Circulation (IF 35.5) Pub Date : 2025-01-27 C David Mazer,Alan R Moody,Hwee Teoh,Adrian Quan,Randi Elituv,Thayalasuthan Vivekanandan,Peiyu Li,Kevin E Thorpe,Myriam Lafreniere-Roula,Raj Verma,Michael Moroney,Jack H Casey,Navneet Singh,Aditya Bharatha,Rasha Mahmoud,Regis Manorajah,Andrew Jayarajah,Anish N Kapadia,Andrew D Dueck,Mohammed Al-Omran,Deepak L Bhatt,Lawrence A Leiter,Subodh Verma
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Response by Hoeper et al to Letter Regarding Article, "Randomized, Multicenter Study to Assess the Effects of Different Doses of Sildenafil on Mortality in Adults with Pulmonary Arterial Hypertension". Circulation (IF 35.5) Pub Date : 2025-01-27 Marius M Hoeper,Scott Haughie,Tarek Hassan,Susanne Vogt,Sarah Hackley
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Relatively Increased CO2 Delivered to the Brain From the Descending Aorta Leading to an Elevated Respiratory Rate Causing Differential Hypocapnia (RIDDLER or East-West Syndrome): New Pitfalls in Awake Peripheral V-A ECMO. Circulation (IF 35.5) Pub Date : 2025-01-27 Alex Rosenberg,Louit Thakuria,Christophe Vandenbriele
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Letter by Yan et al Regarding Article, "Randomized, Multicenter Study to Assess the Effects of Different Doses of Sildenafil on Mortality in Adults With Pulmonary Arterial Hypertension". Circulation (IF 35.5) Pub Date : 2025-01-27 Peijing Yan,Min Zhang,Yunshan Cao
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Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration-Tobacco Working Group. Circulation (IF 35.5) Pub Date : 2025-01-27 Zhiqi Yao,Erfan Tasdighi,Zeina A Dardari,Kunal K Jha,Ngozi Osuji,Tanuja Rajan,Ellen Boakye,Carlos J Rodriguez,Kunihiro Matsushita,Eleanor M Simonsick,Joao A C Lima,Rachel Widome,Debbie L Cohen,Lawrence J Appel,Amit Khera,Michael E Hall,Suzanne Judd,Shelley A Cole,Ramachandran S Vasan,Emelia J Benjamin,Aruni Bhatnagar,Andrew P DeFilippis,Michael J Blaha
BACKGROUND Understanding the association of tobacco product use with subclinical markers is essential in evaluating health effects to inform regulatory policy. This is particularly relevant for noncigarette products (eg, cigars, pipes, and smokeless tobacco), which have been understudied because of their low prevalence in individual cohort studies. METHODS This cross-sectional study included 98 450
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Evidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting. Circulation (IF 35.5) Pub Date : 2025-01-22 Yogesh N V Reddy,Atsushi Tada,Masaru Obokata,Rickey E Carter,David M Kaye,M Louis Handoko,Mads J Andersen,Kavita Sharma,Ryan J Tedford,Margaret M Redfield,Barry A Borlaug
BACKGROUND Plasma NT-proBNP (N-terminal pro-B-type natriuretic peptide) is commonly used to diagnose heart failure with preserved ejection fraction (HFpEF), but its diagnostic performance in the ambulatory/outpatient setting is unknown because previous studies lacked objective reference standards. METHODS Among patients with chronic dyspnea, diagnosis of HFpEF or noncardiac dyspnea was determined conclusively
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Response by Park and Kang to Letter Regarding Article, "Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial". Circulation (IF 35.5) Pub Date : 2025-01-21 Sung-Ji Park,Duk-Hyun Kang
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An Advocacy Agenda for the Human Brain: Moving From Brain Health to Brain Capital. Circulation (IF 35.5) Pub Date : 2025-01-21 Mitchell S V Elkind,Harris Eyre,Cheryl Pegus
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AL or ATTR Amyloidosis? Never Two Without Three. Circulation (IF 35.5) Pub Date : 2025-01-21 Mario Nuvolone,Giuseppe D Sanna,Giovanni Palladini
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ADMET-AI Enables Interpretable Predictions of Drug-Induced Cardiotoxicity. Circulation (IF 35.5) Pub Date : 2025-01-21 Souhrid Mukherjee,Kyle Swanson,Parker Walther,Rabindra V Shivnaraine,Jeremy Leitz,Paul D Pang,James Zou,Joseph C Wu
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Letter by Wang and Peng Regarding Article, "Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial". Circulation (IF 35.5) Pub Date : 2025-01-21 Junwen Wang,Yong Peng
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SGLT Inhibitors in Persons With Heart Failure and Type 1 Diabetes: Filling the Therapeutic Gap. Circulation (IF 35.5) Pub Date : 2025-01-21 Ify R Mordi,Rory J McCrimmon,Chim C Lang
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Assessing and Addressing Cardiovascular and Obstetric Risks in Patients Undergoing Assisted Reproductive Technology: A Scientific Statement From the American Heart Association. Circulation (IF 35.5) Pub Date : 2025-01-15 Rina Mauricio,Garima Sharma,Jennifer Lewey,Rose Tompkins,Torie Plowden,Kathryn Rexrode,Mary Canobbio,Jenna Skowronski,Afshan Hameed,Candice Silversides,Harmony Reynolds,Arthur Vaught,
The use of assisted reproductive technology (ART) is growing, both to assist individuals with infertility and for fertility preservation. Individuals with cardiovascular disease (CVD), or risk factors for CVD, are increasingly using ART. Thus, knowing how to care for patients undergoing ART is important for the cardiovascular clinician. In this scientific statement, we review the ART process and known
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Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism: A Pilot Randomized Controlled Trial. Circulation (IF 35.5) Pub Date : 2025-01-13 Jinbo Hu,Qixin Zhou,Yue Sun,Zhengping Feng,Jun Yang,Wenwen He,Ying Song,Yue Wang,Xiangjun Chen,Hang Shen,Ying Jing,Shumin Yang,Qifu Li,
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Global Rounds Afghanistan: A Critical Overview of Cardiovascular Medicine. Circulation (IF 35.5) Pub Date : 2025-01-13 Abdul Wahed Sidiqi,Diana Dad Zada,Nader Ahmad Exeer
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Response by Sun et al to Letter Regarding Article, "Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction". Circulation (IF 35.5) Pub Date : 2025-01-13 Meiyan Sun,Shufang He,Ji Hu,Ye Zhang
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Letter by Chen et al Regarding Article, "Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction". Circulation (IF 35.5) Pub Date : 2025-01-13 Jun-Zhang Chen,Yi Liang,Bo Liang
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Cardiac Plasticity in Hypertrophic Cardiomyopathy: Exercise as Medicine? Circulation (IF 35.5) Pub Date : 2025-01-13 James P MacNamara,Michael P Ayers
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Swinging Pendulum Between Risks and Benefits of Antiplatelet Agents: A Call for Consistency in the Interpretation of Evidence and Guideline Recommendations. Circulation (IF 35.5) Pub Date : 2025-01-13 Antonio Landi,Diana A Gorog,Marco Valgimigli
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Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy. Circulation (IF 35.5) Pub Date : 2025-01-09 Luke Wooster,Matthew J O'Connor,Xuemei Zhang,Constantine D Mavroudis,Katsuhide Maeda,Humera Ahmed,Jonathan Edwards,Kimberly Y Lin,Carol Wittlieb-Weber,Joseph Rossano,Jonathan B Edelson
BACKGROUND The United Network of Organ Sharing made changes to the priority for allocation of hearts for transplantation (HT) in 2016 for pediatric patients and 2018 for adult patients. Although recent work has evaluated the impact of the revised allocation systems on mechanical circulatory support practices and waitlist outcomes, there are limited data that focus more specifically on the impact of
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Prevalence and Clinical Outcomes of Discordant Lesions Between Fractional Flow Reserve and Nonhyperemic Pressure Ratios in Clinical Practice: The J-PRIDE Registry. Circulation (IF 35.5) Pub Date : 2025-01-09 Shoichi Kuramitsu,Yoshiaki Kawase,Tomohiro Shinozaki,Takenori Domei,Futoshi Yamanaka,Umihiko Kaneko,Tsunekazu Kakuta,Kazunori Horie,Hidenobu Terai,Hirohiko Ando,Yasutsugu Shiono,Toru Tagashira,Kazutaka Nogi,Takashi Kubo,Taku Asano,Jun Shiraishi,Hiromasa Otake,Akinori Sugano,Reo Anai,Atsushi Iwai,Yuetsu Kikuta,Hidetaka Nishina,Tsutomu Fujita,Tetsuya Amano,Masashi Iwabuchi,Hiroyoshi Yokoi,Takashi Akasaka
BACKGROUND Limited large-scale, real-world data exist on the prevalence and clinical impact of discordance between fractional flow reserve (FFR) and nonhyperemic pressure ratios (NHPRs). METHODS The J-PRIDE registry (Clinical Outcomes of Japanese Patients With Coronary Artery Disease Assessed by Resting Indices and Fractional Flow Reserve: A Prospective Multicenter Registry) prospectively enrolled
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Personalized Heart Digital Twins Detect Substrate Abnormalities in Scar-Dependent Ventricular Tachycardia. Circulation (IF 35.5) Pub Date : 2025-01-06 Michael C Waight,Adityo Prakosa,Anthony C Li,Nick Bunce,Anna Marciniak,Natalia A Trayanova,Magdi M Saba
BACKGROUND Current outcomes from catheter ablation for scar-dependent ventricular tachycardia (VT) are limited by high recurrence rates and long procedure durations. Personalized heart digital twin technology presents a noninvasive method of predicting critical substrate in VT, and its integration into clinical VT ablation offers a promising solution. The accuracy of the predictions of digital twins
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Cardiovascular-Liver-Metabolic Health: Recommendations in Screening, Diagnosis, and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Cardiovascular Disease via Modified Delphi Approach. Circulation (IF 35.5) Pub Date : 2024-12-26 Nicholas W S Chew,Anurag Mehta,Rachel Sze Jen Goh,Audrey Zhang,Yiming Chen,Bryan Chong,Han Shi Jocelyn Chew,Asim Shabbir,Adrian Brown,Georgios K Dimitriadis,Daniel Q Huang,Roger Foo,Carel W le Roux,Gemma A Figtree,Marat Fudim,Ambarish Pandey,Mamas A Mamas,Derek J Hausenloy,A Mark Richards,Stephen J Nicholls,Mark Y Chan,Mark D Muthiah,Arun Sanyal,Laurence S Sperling
There is a new awareness of the widespread nature of metabolic dysfunction-associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrinologists, and the wider multidisciplinary team to address the need for earlier identification of those with MASLD who are at increased risk for CVD. The
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What Is the Mechanism of Atrial Fibrillation Initiation? Circulation (IF 35.5) Pub Date : 2024-12-26 Gurukripa N Kowlgi,Samuel J Asirvatham,Konstantinos C Siontis
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Spotlight on YAP: Unlocking New Insights to Overcome the Barriers to Heart Regeneration. Circulation (IF 35.5) Pub Date : 2024-12-26 Nivedhitha Velayutham,Richard T Lee
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Geographic Disparities in Availability of Hospital-Based Cardiac Services Across the United States. Circulation (IF 35.5) Pub Date : 2024-12-26 Gabriel A Benavidez,Shanikque Blackwell,Peiyin Hung,Elizabeth Crouch
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40th Anniversary of the TIMI Study Group. Circulation (IF 35.5) Pub Date : 2024-12-26 Marc S Sabatine,Eugene Braunwald
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Activation of Imprinted Gene PW1 Promotes Cardiac Fibrosis After Ischemic Injury. Circulation (IF 35.5) Pub Date : 2024-12-20 Shan Kou,Zhengkai Lu,Defang Deng,Min Ye,Yu Sui,Lieyang Qin,Teng Feng,Zhen Jiang,Jufeng Meng,Chao-Po Lin,Xiajun Li,Chen Liu,Juan Tang,Hui Zhang
BACKGROUND Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition in the myocardium, is an important target for heart disease treatments. Pw1 (paternally expressed gene 3) is an imprinted gene expressed from the paternal allele, and de novo purine biosynthesis (DNPB) is a crucial pathway for nucleotide synthesis. However, the roles of PW1 and DNPB in ECM production by cardiac
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Covered Stent Correction for Sinus Venosus Atrial Septal Defects, an Emerging Alternative to Surgical Repair: Results of an International Registry. Circulation (IF 35.5) Pub Date : 2024-12-19 Eric Rosenthal,Shakeel A Qureshi,Kothandam Sivakumar,Matthew Jones,San-Fui Yong,Saleha Kabir,Pramod Sagar,Puthiyedath Thejaswi,Sebastien Hascoet,Clement Batteux,Younes Boudjemline,Ziyad M Hijazi,Jamil A Aboulhosn,Daniel S Levi,Morris M Salem,Edwin Francis,Aleksander Kempny,Alain Fraisse,Carles Bautista-Rodriguez,Kevin Walsh,Damien Kenny,Brian Traynor,Salim N Al Maskari,James R Bentham,László Környei
BACKGROUND Covered stent correction for a sinus venosus atrial septal defect (SVASD) was first performed in 2009. This innovative approach was initially viewed as experimental and was reserved for highly selected patients with unusual anatomic variants. In 2016, increasing numbers of procedures began to be performed, and in several centers, it is now offered as a standard of care option alongside surgical
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METTL4-Mediated Mitochondrial DNA N6-Methyldeoxyadenosine Promoting Macrophage Inflammation and Atherosclerosis. Circulation (IF 35.5) Pub Date : 2024-12-17 Longbin Zheng,Xiang Chen,Xian He,Huiyuan Wei,Xinyu Li,Yongkang Tan,Jiao Min,Minghong Chen,Yunjia Zhang,Mengdie Dong,Quanwen Yin,Mengdie Xue,Lulu Zhang,Da Huo,Hong Jiang,Tingyou Li,Fei Li,Xin Wang,Xuesong Li,Hongshan Chen
BACKGROUND Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA). However, the role of METTL4-mediated mitoepigenetic regulation in atherosclerosis is still unknown. This study aims to investigate the potential involvement of METTL4 in atherosclerosis, explore
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Aortic Stenosis and Coronary Artery Disease: Decision-Making Between Surgical and Transcatheter Management. Circulation (IF 35.5) Pub Date : 2024-12-16 Daijiro Tomii,Thomas Pilgrim,Michael A Borger,Ole De Backer,Jonas Lanz,David Reineke,Matthias Siepe,Stephan Windecker
Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist and share pathophysiological mechanisms. The proportion of patients with AS and CAD requiring revascularization varies widely because of uncertainty about best clinical practices. Although combined surgical aortic valve replacement and coronary artery bypass grafting has been the standard of care, management options in patients
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Letter by Wang and Huang Regarding Article, "Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism". Circulation (IF 35.5) Pub Date : 2024-12-16 Hai-Yan Wang,Feng Huang
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Cardiac Reprogramming and Gata4 Overexpression Reduce Fibrosis and Improve Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction. Circulation (IF 35.5) Pub Date : 2024-12-14 Yu Yamada,Taketaro Sadahiro,Koji Nakano,Seiichiro Honda,Yuto Abe,Tatsuya Akiyama,Ryo Fujita,Masashi Nakamura,Takashi Maeda,Yuta Kuze,Masaya Onishi,Masahide Seki,Yutaka Suzuki,Chikara Takeuchi,Yuka W Iwasaki,Kensaku Murano,Mamiko Sakata-Yanagimoto,Shigeru Chiba,Hideyuki Kato,Hiroaki Sakamoto,Yuji Hiramatsu,Masaki Ieda
BACKGROUND Heart failure with preserved ejection fraction (HFpEF) is a major health concern. Pathological stimuli and interactions between cardiac fibroblasts (CFs) and other cell types may lead to cardiac fibrosis and diastolic dysfunction, which are hallmarks of HFpEF. Interstitial and perivascular cardiac fibrosis correlates with poor prognosis in HFpEF; however, mechanisms of fibrosis remain poorly
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Left Ventricular Ejection Fraction and Implantable Cardioverter-Defibrillator in Non-ischemic Heart Failure with Reduced Ejection Fraction: Insights from DANISH. Circulation (IF 35.5) Pub Date : 2024-12-10 Seiko N Doi,Jawad H Butt,Jens Jakob Thune,Jens C Nielsen,Jens Haarbo,Niels E Bruun,Line L Olesen,Lars Videbæk,Finn Gustafsson,Hans Eiskjær,Christian Hassager,Jesper H Svendsen,Dan E Høfsten,Steen Pehrson,Lars Køber
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Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans. Circulation (IF 35.5) Pub Date : 2024-12-10 Bo Sun,Mingke Ni,Yanhui Li,Zhenpeng Song,Hui Wang,Hai-Lei Zhu,Jinhong Wei,Darrell Belke,Shitian Cai,Wenting Guo,Jinjing Yao,Shanshan Tian,John Paul Estillore,Ruiwu Wang,Mads Toft Sondergaard,Malene Brohus,Palle Duun Rohde,Yongxin Mu,Alexander Vallmitjana,Raul Benitez,Leif Hove-Madsen,Michael Toft Overgaard,Glenn I Fishman,Ju Chen,Shubhayan Sanatani,Arthur A M Wilde,Michael Fill,Josefina Ramos-Franco
BACKGROUND Ca2+ mishandling in cardiac Purkinje cells is a well-known cause of cardiac arrhythmias. The Purkinje cell resident inositol 1,4,5-trisphosphate receptor 1 (ITPR1) is believed to play an important role in Ca2+ handling, and ITPR1 gain-of-function (GOF) has been implicated in cardiac arrhythmias. However, nearly all known disease-associated ITPR1 variants are loss-of-function and are primarily
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Cognitive Dysfunction in Heart Failure With Preserved Ejection Fraction: Uncovering the Consequences of an Overlooked Comorbidity. Circulation (IF 35.5) Pub Date : 2024-12-09 Jesús Álvarez-García
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Precision Medicine in People at Risk for Diabetes and Atherosclerotic Cardiovascular Disease: A Fresh Perspective on Prevention. Circulation (IF 35.5) Pub Date : 2024-12-09 Andreas L Birkenfeld,Paul W Franks,Viswanathan Mohan
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Scientific and Clinical Impacts of UK Biobank in Cardiovascular Medicine. Circulation (IF 35.5) Pub Date : 2024-12-09 Adam J Lewandowski,Martin K Rutter,Rory Collins
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Letter by Huang et al Regarding Article, "Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease". Circulation (IF 35.5) Pub Date : 2024-12-09 Huixin Huang,Xuqi Yang,Kai Yang
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Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy. Circulation (IF 35.5) Pub Date : 2024-12-05 Joshua K Meisner,Aaron Renberg,Eric D Smith,Yao-Chang Tsan,Brynn Elder,Abbey Bullard,Owen Merritt,Sean L Zheng,Neal Lakdawala,Anjali Owens,Thomas D Ryan,Erin M Miller,Joseph Rossano,Kimberly Y Lin,Brian Claggett,Euan Ashley,Michelle Michels,Rachel Lampert,John C Stendahl,Dominic Abrahams,Christopher Semsarian,Victoria N Parikh,Matthew Wheeler,Jodie Ingles,Sharlene M Day,Sara Saberi,Mark W Russell,Michael
BACKGROUND Classically, hypertrophic cardiomyopathy (HCM) has been viewed as a single-gene (monogenic) disease caused by pathogenic variants in sarcomere genes. Pathogenic sarcomere variants are individually rare and convey high risk for developing HCM (highly penetrant). Recently, important polygenic contributions have also been characterized. Low penetrance sarcomere variants (LowSVs) at intermediate
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Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions. Circulation (IF 35.5) Pub Date : 2024-12-05 Steven D Brooks,A Parker Ruhl,Xianke Zeng,Phillip Cruz,Sergio A Hassan,Olena Kamenyeva,Md Abdul Hakim,Lauryn A Ridley,Bianca M Nagata,Juraj Kabat,Sundar Ganesan,Rachel L Smith,Mary Jackson,Jessica Nino de Rivera,Alison J McLure,Jarrett M Jackson,Robert O Emeh,Naomi Tesfuzigta,Kyeisha Laurence,Stacy Joyce,Christina Yek,Sophana Chea,Derron A Alves,Brant E Isakson,Jessica Manning,Jeremy L Davis,Hans C
BACKGROUND Severe malaria is associated with impaired nitric oxide (NO) synthase (NOS)-dependent vasodilation, and reversal of this deficit improves survival in murine models. Malaria might have selected for genetic polymorphisms that increase endothelial NO signaling and now contribute to heterogeneity in vascular function among humans. One protein potentially selected for is alpha globin, which,
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Letter by Yang and Zhang Regarding Article, "Clinical Impact of Routine Assessment of Patient-Reported Health Status in Heart Failure Clinic: The PRO-HF Trial". Circulation (IF 35.5) Pub Date : 2024-12-02 Xinyue Yang,Zhiqiang Zhang
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In Vivo Cardiovascular Molecular Imaging: Contributions to Precision Medicine and Drug Development. Circulation (IF 35.5) Pub Date : 2024-12-02 Jonathan R Lindner,Matteo Morello
Conventional forms of noninvasive cardiovascular imaging that evaluate morphology, function, flow, and metabolism play a vital role in individual treatment decisions, often based on guidelines. Innovations in molecular imaging have enhanced our ability to spatially quantify the expression of a wider array of disease-related proteins, genes, or cell types, or the activity of specific pathogenic pathways
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Reply by Sandhu et al to Letter Regarding Article, "Clinical Impact of Routine Assessment of Patient-Reported Health Status in Heart Failure Clinic: The PRO-HF Trial". Circulation (IF 35.5) Pub Date : 2024-12-02 Alexander T Sandhu,John A Spertus,Paul A Heidenreich