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Focused ultrasound-mediated cerium-based nanoreactor against Parkinson's disease via ROS regulation and microglia polarization J. Control. Release (IF 10.8) Pub Date : 2024-03-14 Yifei Gao, Limin Zhai, Jiapeng Chen, Danmin Lin, Ling-Kun Zhang, Hao Yang, Runcai Yang, LinJing Mi, Yan-Qing Guan
Neuronal damage caused by oxidative stress and inflammatory microenvironment dominated by microglia are the main obstacles in the treatment of Parkinson's disease (PD). In this study, we developed an integrated nanoreactor Q@CeBG by encapsulating CeO nanozyme and quercetin (Que) into glutathione-modified bovine serum albumin, and then selected focused ultrasound (FUS) to temporarily open the blood-brain
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Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation J. Control. Release (IF 10.8) Pub Date : 2024-03-14 Leonard Krupnik, Jonathan Avaro, Marianne Liebi, Neda Iranpour Anaraki, Joachim Kohlbrecher, Alla Sologubenko, Stephan Handschin, Andrzej J. Rzepiela, Christian Appel, Tiberiu Totu, Clement E. Blanchet, Amy E. Barton Alston, Reinaldo Digigow, Erik Philipp, Beat Flühmann, Bruno F.B. Silva, Antonia Neels, Peter Wick
Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a plethora of physicochemical characterisation data and clinical studies are available for these products, evidence-based correlation between physicochemical
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Immune cell-derived extracellular vesicles for precision therapy of inflammatory-related diseases J. Control. Release (IF 10.8) Pub Date : 2024-03-12 Shuo Li, Wenqing Li, Xianggui Wu, Beiyuan Zhang, Lisha Liu, Lifang Yin
Inflammation-related diseases impose a significant global health burden, necessitating urgent exploration of novel treatment modalities for improved clinical outcomes. We begin by discussing the limitations of conventional approaches and underscore the pivotal involvement of immune cells in the inflammatory process. Amidst the rapid growth of immunology, the therapeutic potential of immune cell-derived
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Microenvironment-responsive smart hydrogels with antibacterial activity and immune regulation for accelerating chronic wound healing J. Control. Release (IF 10.8) Pub Date : 2024-03-12 Xiangtian Deng, Ye Wu, YunFeng Tang, Zilu Ge, Dong Wang, Cheng Zheng, Renliang Zhao, Wei Lin, Guanglin Wang
Current therapeutic strategies for chronic refractory wounds remain challenge owing to their unfavorable wound microenvironment and poor skin regeneration ability. Thus far, a regimen for effective chronic refractory wounds management involves bacterial elimination, alleviation of oxidative stress, inhibition of inflammatory response, and promotion of angiogenesis. In this work, an injectable glycopeptide
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Bio-responsive Au-miR-183 inhibitor enhances immunotherapy in hepatocellular carcinoma by inducing immunogenic cell death J. Control. Release (IF 10.8) Pub Date : 2024-03-11 Liang Yin, Yu Wei, Ya Liu, Xianwei Mo, Jintong Song, Weijuan Cai
The treatment of advanced hepatocellular carcinoma (HCC) is limited, and immunotherapy is the current research focus of multi-disciplinary collaborative comprehensive treatment of HCC. Herein, we constructed a bio-responsive Au-miR-183 inhibitor (Au@miR-183i) delivery system targeting liver cancer stem cells (LCSCs), and adopted the strategy of combining αPD-L1 immunotherapy. The multifunctional Au@miR-183i
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Mesoporous zinc oxide-based drug delivery system offers an antifungal and immunoregulatory strategy for treating keratitis J. Control. Release (IF 10.8) Pub Date : 2024-03-10 Lingwen Gu, Jing Lin, Qian Wang, Fanyue Meng, Geng Niu, Hao Lin, Menghui Chi, Zhuhui Feng, Hengrui Zheng, Daohao Li, Guiqiu Zhao, Cui Li
Fungal keratitis is a refractory eye disease that is prone to causing blindness. Fungal virulence and inflammatory responses are two major factors that accelerate the course of fungal keratitis. However, the current antifungal drugs used for treatment usually possess transient residence time on the ocular surface and low bioavailability deficiencies, which limit their therapeutic efficacy. In this
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Corrigendum to “Ultrasound-responsive polymersomes capable of endosomal escape for efficient cancer therapy” [Journal of Controlled Release 322 (2020) 81–94] J. Control. Release (IF 10.8) Pub Date : 2024-03-09 Ping Wei, Min Sun, Bo Yang, Jiangang Xiao, Jianzhong Du
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Placenta-anchored tadalafil liposomes rescues intrauterine growth restriction through continuous placental blood perfusion improvement J. Control. Release (IF 10.8) Pub Date : 2024-03-08 Miao Tang, Yu Xin, Yunchun Zhao, Xiao Zhang, Meng Zhang, Dongli Sun, Xiaojun Zhu, Yao Yao, Weidong Fei, Caihong Zheng
Physiological or pathological hypoperfusion of the placenta is one of the main causes of intrauterine growth restriction (IUGR) which poses a significant risk to the health of the fetus and newborn. Tadalafil, a 5-type phosphodiesterase inhibitor, has previously been found to improve the symptoms of IUGR in various clinical studies. Unfortunately, its clinical utility is hindered by its limited water
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Glucose-responsive insulin microneedle patches for long-acting delivery and release visualization J. Control. Release (IF 10.8) Pub Date : 2024-03-08 Ye He, Nanxi Chen, Mingming Zang, Jinghai Zhang, Youxi Zhang, Hongyan Lu, Qinfu Zhao, Yuling Mao, Yue Yuan, Siling Wang, Yikun Gao
Limited drug loading and incomplete drug release are two major obstacles that traditional polymeric microneedles (MNs) have to overcome. For smart controlled-release MNs, since drug release duration is uncertain, a clear indication of the finish of drug release is also important for patient guidance on the timing of the next dose. In this study, MN with a triple structure of a glucose-responsive shell
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Fibroblast function recovery through rejuvenation effect of nanovesicles extracted from human adipose-derived stem cells irradiated with red light J. Control. Release (IF 10.8) Pub Date : 2024-03-08 Jiyu Hyun, Jiin Eom, Jisoo Im, Yu-Jin Kim, Inwoo Seo, Sung-Won Kim, Gwang-Bum Im, Yeong Hwan Kim, Dong-Hyun Lee, Hyun Su Park, Dae Won Yun, Dong-Ik Kim, Jeong-Kee Yoon, Soong Ho Um, Dae Hyeok Yang, Suk Ho Bhang
Fibroblasts (hDFs) are widely employed for skin regeneration and the treatment of various skin disorders, yet research were rarely investigated about restoration of diminished therapeutic efficacy due to cell senescence. The application of stem cell and stem cell-derived materials, exosomes, were drawn attention for the restoration functionality of fibroblasts, but still have limitation for unintended
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Cyclization-enhanced poly(β-amino ester)s vectors for efficient CRISPR gene editing therapy J. Control. Release (IF 10.8) Pub Date : 2024-03-08 Xianqing Wang, Yinghao Li, Sigen A, Jing Lyu, Xi Wang, Zhonglei He, Irene Lara-Sáez, Ming Li, Wenxin Wang
Among non-viral gene delivery vectors, poly(β-amino ester)s (PAEs) are one of the most versatile candidates because of their wide monomer availability, high polymer flexibility, and superior gene transfection performance both and . Over two decades, PAEs have evolved from linear to highly branched structures, significantly enhancing gene delivery efficacy. Building on the proven efficient sets of monomers
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Smart exosomes enhance PDAC targeted therapy J. Control. Release (IF 10.8) Pub Date : 2024-03-07 Justin F. Creeden, Jonathan Sevier, Jian-Ting Zhang, Yakov Lapitsky, F. Charles Brunicardi, Ge Jin, John Nemunaitis, Jing-Yuan Liu, Andrea Kalinoski, Donald Rao, Shi-He Liu
Exosomes continue to attract interest as a promising nanocarrier drug delivery technology. They are naturally derived nanoscale extracellular vesicles with innate properties well suited to shuttle proteins, lipids, and nucleic acids between cells. Nonetheless, their clinical utility is currently limited by several major challenges, such as their inability to target tumor cells and a high proportion
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Dandelion-derived vesicles-laden hydrogel dressings capable of neutralizing Staphylococcus aureus exotoxins for the care of invasive wounds J. Control. Release (IF 10.8) Pub Date : 2024-03-06 Shenyu Tan, Zhuoya Liu, Minghui Cong, Xiaoqing Zhong, Yinping Mao, Mingjie Fan, Fangwen Jiao, Hongzhi Qiao
Delayed wound healing caused by bacterial infection remains a major challenge in clinical treatment. Exotoxins incorporated in bacterial extracellular vesicles play a key role as the disease-causing virulence factors. Safe and specific antivirulence agents are expected to be developed as an effective anti-bacterial infection strategy, instead of single antibiotic therapy. Plant-derived extracellular
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Cellulase-assisted platelet-rich plasma release from nanofibrillated cellulose hydrogel enhances wound healing J. Control. Release (IF 10.8) Pub Date : 2024-03-06 Elle Koivunotko, Raili Koivuniemi, Julia Monola, Riina Harjumäki, Chris S. Pridgeon, Mari Madetoja, Jere Linden, Lauri Paasonen, Saara Laitinen, Marjo Yliperttula
Platelet-rich plasma (PRP) is a source of growth factors, which are implicated in active tissue regeneration. However, after transplantation the efficacy of these bioactive compounds is often diminished due to rapid degradation and untargeted localization. For this reason, we evaluated the potential of nanofibrillated cellulose (NFC) hydrogel as a PRP carrier. NFC hydrogel is an animal-free biomaterial
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Adsorbed polymer conjugates to adaptively inhibit blood coagulation activation by medical membranes J. Control. Release (IF 10.8) Pub Date : 2024-03-06 Tina Helmecke, Dominik Hahn, André Ruland, Mikhail V. Tsurkan, Manfred F. Maitz, Carsten Werner
Adaptive drug release can combat coagulation and inflammation activation at the blood-material interface with minimized side effects. For that purpose, poly(styrene--maleic-anhydride) copolymers were conjugated to heparin via coagulation-responsive linker peptides and shown to tightly adsorb onto poly(ethersulfone) (PES)-surfaces from aqueous solutions as monolayers. Coagulation-responsive release
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Adoptive cell therapy for solid tumors beyond CAR-T: Current challenges and emerging therapeutic advances J. Control. Release (IF 10.8) Pub Date : 2024-03-06 Tingrui Zhang, Zongguang Tai, Fengze Miao, Xinyue Zhang, Jiadong Li, Quangang Zhu, Hua Wei, Zhongjian Chen
Adoptive cellular immunotherapy using immune cells expressing chimeric antigen receptors (CARs) is a highly specific anti-tumor immunotherapy that has shown promise in the treatment of hematological malignancies. However, there has been a slow progress toward the treatment of solid tumors owing to the complex tumor microenvironment that affects the localization and killing ability of the CAR cells
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Peptide targeting improves the delivery and therapeutic index of glucocorticoids to treat rheumatoid arthritis J. Control. Release (IF 10.8) Pub Date : 2024-03-05 Xian Wu, Hong Guo, Hui Gao, Yiqin Li, Xiangxiang Hu, Mitchell A. Kowalke, Yue-Xuan Li, Yushuang Wei, Jiaqi Zhao, Jennifer Auger, Bryce A. Binstadt, Hong-Bo Pang
Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by excessive inflammation in the joints. Glucocorticoid drugs are used clinically to manage RA symptoms, while their dosage and duration need to be tightly controlled due to severe adverse effects. Using dexamethasone (DEX) as a model drug, we explored here whether peptide-guided delivery could increase the safety and therapeutic
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Mucoadhesive liposomal delivery system synergizing anti-inflammation and anti-oxidation for enhanced treatment against dry eye disease J. Control. Release (IF 10.8) Pub Date : 2024-03-04 Kexin Huang, Rong Guo, Haoyuan Luo, Houqin Liu, Dong Chen, Tao Deng, Jiaxin Li, Jiao He, Zhuping Xu, Man Li, Qin He
Dry eye disease (DED) is a common and frequent ocular surface disease worldwide, which can cause severe ocular surface discomfort and blurred vision. Inflammation and reactive oxygen species (ROS) play decisive roles in the development of DED. However, existing treatments usually focus on anti-inflammation while ignore the role of ROS in DED. Ever worse, the clinical preparations are easily cleared
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Systemic delivery of proteins using novel peptides via the sublingual route J. Control. Release (IF 10.8) Pub Date : 2024-03-04 Jiamin Wu, Natalie Jones, Lukas Hohenwarter, Feng Zhao, Vanessa Chan, Zheng Tan, Tiffany Carlaw, Tessa Morin, Jing Li, Tejinder Kaur, Lucas J. Andrew, Colin J.D. Ross, Sarah Hedtrich, Shyh-Dar Li
Therapeutic proteins often require needle-based injections, which compromise medication adherence especially for those with chronic diseases. Sublingual administration provides a simple and non-invasive alternative. Herein, two novel peptides (lipid-conjugated protamine and a protamine dimer) were synthesized to enable sublingual delivery of proteins through simple physical mixing with the payloads
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Locally delivered hydrogels with controlled release of nanoscale exosomes promote cardiac repair after myocardial infarction J. Control. Release (IF 10.8) Pub Date : 2024-03-04 Xi Tan, Jing Zhang, Yongyuan Heng, Lin Chen, Yi Wang, Shaojun Wu, Xiaoli Liu, Biao Xu, Ziyi Yu, Rong Gu
Compared with stem cells, exosomes as a kind of nanoscale carriers intrinsically loaded with diverse bioactive molecules, which had the advantages of high safety, small size, and ethical considerations in the treatment of myocardial infarction, but there are still problems such as impaired stability and rapid dissipation. Here, we introduce a bioengineered injectable hyaluronic acid hydrogel designed
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In situ bio-mineralized Mn nanoadjuvant enhances anti-influenza immunity of recombinant virus-like particle vaccines J. Control. Release (IF 10.8) Pub Date : 2024-03-04 Yanan Sheng, Zhengjun Li, Xuan Lin, Liuyang Wang, Hongyu Zhu, Zhiguo Su, Songping Zhang
Virus like particles (VLPs) have been well recognized as one of the most important vaccine platforms due to their structural similarity to natural viruses to induce effective humoral and cellular immune responses. Nevertheless, lack of viral nucleic acids in VLPs usually leads the vaccine candidates less efficient in provoking innate immune against viral infection. Here, we constructed a biomimetic
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A biodegradable semiconducting polymer phototherapeutic agent for safe cancer phototherapy J. Control. Release (IF 10.8) Pub Date : 2024-03-02 Qiang Wang, Zhuoheng Gan, Qiankun Shi, Yonggang Li, Li Qi, Wenbo Wu, Fang Hu
Combined photodynamic therapy (PDT) and photothermal therapy (PTT) not only effectively reduce the hypoxic resistance to PDT, but also overcome the heat shock effect to PTT. However, the residual phototherapeutic agents still produce reactive oxygen species (ROS) to damage normal tissue under sunlight after treatment, which induces undesirable side effects to limit their biomedical application. Herein
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A redox-responsive prodrug for tumor-targeted glutamine restriction J. Control. Release (IF 10.8) Pub Date : 2024-02-29 Céline Jasmin Prange, Nadia Yasmina Ben Sayed, Bing Feng, Christine Goepfert, Daniel Ortiz Trujillo, Xile Hu, Li Tang
Modulating the metabolism of cancer cells, immune cells, or both is a promising strategy to potentiate cancer immunotherapy in the nutrient-competitive tumor microenvironment. Glutamine has emerged as an ideal target as cancer cells highly rely on glutamine for replenishing the tricarboxylic acid cycle in the process of aerobic glycolysis. However, non-specific glutamine restriction may induce adverse
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Enhancing photodynamic immunotherapy by reprograming the immunosuppressive tumor microenvironment with hypoxia relief J. Control. Release (IF 10.8) Pub Date : 2024-02-29 Mengying He, Mengyao Zhang, Tao Xu, Shujuan Xue, Dazhao Li, Yanan Zhao, Feng Zhi, Dawei Ding
Tumor hypoxia impairs the generation of reactive oxygen species and the induction of immunogenic cell death (ICD) for photodynamic therapy (PDT), thus impeding its efficacy and the subsequent immunotherapy. In addition, hypoxia plays a critical role in forming immunosuppressive tumor microenvironments (TME) by regulating the infiltration of immunosuppressive tumor-associated macrophages (TAMs) and
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A natural IgM hitchhiking strategy for delivery of cancer nanovaccines to splenic marginal zone B cells J. Control. Release (IF 10.8) Pub Date : 2024-02-28 Huan Wang, Xiying Wu, Yuhan Sun, Anze Liu, Yingying He, Ziyi Xu, Ying Lu, Changyou Zhan
B cell-targeted cancer vaccines are receiving increasing attention in immunotherapy due to the combined antibody-secreting and antigen-presenting functions. In this study, we propose a natural IgM-hitchhiking delivery strategy to co-deliver tumor antigens and adjuvants to splenic marginal zone B (MZB) cells. We constructed nanovaccines (FA-sLip/OVA/MPLA) consisting of classical folic acid (FA)-conjugated
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Substrate-free dissolving microneedles with barbed shape to increase adhesion and drug-delivery efficiency to skin J. Control. Release (IF 10.8) Pub Date : 2024-02-28 Yingjie Ren, Kaiming Yang, Zhongyan Wang, Zhitong Zhang, Yufeng Chen, Xiaoyi Shi, Jiayan Zhang, Yuxuan Chen, Dong Huang, Junshi Li, Zhihong Li
Microneedle drug delivery has recently emerged as a clinical method, and dissolving microneedles (DMNs) offer exclusive simplicity and efficiency, compared to the other kinds of microneedles. The tips of most currently available DMNs are cone/house-shaped to result in a lower penetration force. Penetration of the needle tips into the skin relies mainly on the back tape or external pressure, and their
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Engineered liposomes targeting hepatic stellate cells overcome pathological barriers and reverse liver fibrosis J. Control. Release (IF 10.8) Pub Date : 2024-02-28 Kaili Wang, Hao Chen, Jiani Zheng, Jiali Chen, Yixuan Chen, Yue Yuan
Dual pathological barriers, including capillarized liver sinusoidal endothelial cells (LSECs) and deposited extracellular matrix (ECM), result in insufficient drug delivery, significantly compromising the anti-fibrosis efficacy. Additionally, excessive reactive oxygen species (ROS) in the hepatic microenvironment are crucial factors contributing to the progression of liver fibrosis. Hence, hyaluronic
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A ferroptosis-reinforced nanocatalyst enhances chemodynamic therapy through dual H2O2 production and oxidative stress amplification J. Control. Release (IF 10.8) Pub Date : 2024-02-24 Xiao-Yu Zhu, Tian-Yu Wang, Hao-Ran Jia, Shun-Yu Wu, Cheng-Zhe Gao, Yan-Hong Li, Xinping Zhang, Bai-Hui Shan, Fu-Gen Wu
The existence of a delicate redox balance in tumors usually leads to cancer treatment failure. Breaking redox homeostasis by amplifying oxidative stress and reducing glutathione (GSH) can accelerate cancer cell death. Herein, we construct a ferroptosis-reinforced nanocatalyst (denoted as HBGL) to amplify intracellular oxidative stress via dual HO production-assisted chemodynamic therapy (CDT). Specifically
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Liposome-based dry powder vaccine immunization targeting the lungs induces broad protection against pneumococcus J. Control. Release (IF 10.8) Pub Date : 2024-02-24 T.C. Rodrigues, D.B. Figueiredo, V.M. Gonçalves, K. Kaneko, I.Y. Saleem, E.N. Miyaji
is an important human pathogen. Currently used conjugate vaccines are effective against invasive disease, but protection is restricted to serotypes included in the formulation, leading to serotype replacement. Furthermore, protection against non-invasive disease is reported to be considerably lower. The development of a serotype-independent vaccine is thus important and Pneumococcal surface protein
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Efficient gene delivery by multifunctional star poly (β-amino ester)s into difficult-to-transfect macrophages for M1 polarization J. Control. Release (IF 10.8) Pub Date : 2024-02-23 Tao Bo, Chenfei Wang, Dingjin Yao, Qiuyu Jiang, Yitong Zhao, Feifei Wang, Wei He, Weiyi Xu, Hao Zhou, Ming Li, Si Zhang, Ruyi Xue
Gene delivery to macrophages holds great promise for cancer immunotherapy. However, traditional gene delivery methods exhibit low transfection efficiency in macrophages. The -shaped topological structure of polymers is known to encapsulate genes inside their cores, thereby facilitating sustained release of the genetic material. Herein, combining the structural advantages of star polymers and the transfection
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Engineered exosomes with enhanced stability and delivery efficiency for glioblastoma therapy J. Control. Release (IF 10.8) Pub Date : 2024-02-23 Yutong Wang, Yiming Huo, Chunyuan Zhao, Heng Liu, Yurou Shao, Chenqi Zhu, Lan An, Xiao Chen, Zhipeng Chen
Due to the blood-brain barrier (BBB), the application of chemical drugs for glioblastoma treatment is severely limited. Recently, exosomes have been widely applied for drug delivery to the brain. However, the differences in brain targeting efficiency among exosomes derived from different cell sources, as well as the premature drug leakage during circulation, still limit the therapeutic efficacy. Here
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Decellularized brain extracellular matrix based NGF-releasing cryogel for brain tissue engineering in traumatic brain injury J. Control. Release (IF 10.8) Pub Date : 2024-02-22 Beom-Seok Kim, Jeong-Uk Kim, Jaewoo Lee, Kyung Min Ryu, Su-Hwan Kim, Nathaniel S. Hwang
Traumatic brain injuries(TBI) pose significant challenges to human health, specifically neurological disorders and related motor activities. After TBI, the injured neuronal tissue is known for hardly regenerated and recovered to their normal neuron physiology and tissue compositions. For this reason, tissue engineering strategies that promote neuronal regeneration have gained increasing attention.
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CD44-targeted melanin-based nanoplatform for alleviation of ischemia/reperfusion-induced acute kidney injury J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Jinghua Sun, Xuhui Zhao, Hao Shen, Jie Dong, Shuo Rong, Wenwen Cai, Ruiping Zhang
Ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) is a serious kidney disease with high morbidity and mortality. However, there is no effective clinical treatment strategy. Herein, we developed a CD44 targeting nanoplatform based on HA-assembled melanin NPs covalently coupled with dexamethasone for I/R-induced AKI therapy by alleviating oxidative/inflammatory- induced damage. The constructed
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Multi-material 3D printed eutectogel microneedle patches integrated with fast customization and tunable drug delivery J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Huan Liu, Xinmeng Zhou, Aminov Nail, Hao Yu, Zilian Yu, Yue Sun, Kun Wang, Nanbin Bao, Decheng Meng, Liran Zhu, Huanjun Li
Microneedle patches are emerging multifunctional platforms for transdermal diagnostics and drug delivery. However, it still remains challenging to develop smart microneedles integrated with customization, sensing, detection and drug delivery by 3D printing strategy. Here, we present an innovative but facile strategy to rationally design and fabricate multifunctional eutectogel microneedle (EMN) patches
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Dual stimuli-responsive and sustained drug delivery NanoSensoGel formulation for prevention of cisplatin-induced ototoxicity J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Neeraj S. Thakur, Iulia Rus, Ethan Sparks, Vibhuti Agrahari
Cisplatin (Pt)-induced ototoxicity (CIO) is delineated as a consequence of Pt-induced intracellular generation of reactive oxygen species (ROS) which can be circumvented by Bucillamine (BUC; an antioxidant drug with sulfhydryl groups) and Diltiazem (DLT, L-type calcium channel blocker). However, its effective accumulation in the Organ of Corti and cell cytoplasm is desired. Therefore, a biocompatible
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Biomimetic nano-chelate diethyldithiocarbamate Cu/Fe for enhanced metalloimmunity and ferroptosis activation in glioma therapy J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Rui Wang, Wenqin Song, Jie Zhu, Xinyue Shao, Chenxiao Yang, Wei Xiong, Bing Wang, Pengfei Zhao, Meiwan Chen, Yongzhuo Huang
Ferroptosis has emerged as a promising therapeutic approach for glioma. However, its efficacy is often compromised by the activated GPX4-reduced glutathione (GSH) system and the poor brain delivery efficiency of ferroptosis inducers. Therefore, suppression of the GPX4-GSH axis to induce the accumulation of lipid peroxides becomes an essential strategy to augment ferroptosis. In this study, we present
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Controlling the function of bioactive worm micelles by enzyme-cleavable non-covalent inter-assembly cross-linking J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Alina Romanovska, Martin Schmidt, Volker Brandt, Jonas Tophoven, Joerg C. Tiller
Drugs that form self-assembled supramolecular structures to be most-active is a promising way of creating new highly specific and active pharmaceuticals. Controlling the activity of bioactive supramolecular structures such as drug-loaded micelles is possible by both core/shell and inter-assembly cross-linking. However, if the flexibility of the assembly is mandatory for the activity cross-linking is
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Essential elements for spatiotemporal delivery of growth factors within bio-scaffolds: A comprehensive strategy for enhanced tissue regeneration J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Tan Chen, Yao Jiang, Jia-Ping Huang, Jing Wang, Zheng-Ke Wang, Pei-Hui Ding
The precise delivery of growth factors (GFs) in regenerative medicine is crucial for effective tissue regeneration and wound repair. However, challenges in achieving controlled release, such as limited half-life, potential overdosing risks, and delivery control complexities, currently hinder their clinical implementation. Despite the plethora of studies endeavoring to accomplish effective loading and
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Lipid-mediated protein corona regulation with increased apolipoprotein A-I recruitment for glioma targeting J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Yiwei Zhang, Wei Xiao, Siqin He, Xue Xia, Wenqin Yang, Zhihang Yang, Haili Hu, Yushan Wang, Xiaorong Wang, Hanmei Li, Yuan Huang, Huile Gao
Protein corona has long been a source of concern, as it might impair the targeting efficacy of targeted drug delivery systems. However, engineered up-regulating the adsorption of certain functional serum proteins could provide nanoparticles with specific targeting drug delivery capacity. Herein, apolipoprotein A-I absorption increased nanoparticles (SPC-PLGA NPs), composed with the Food and Drug Administration
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Lipid core-shell nanoparticles co-deliver FOLFOX regimen and siPD-L1 for synergistic targeted cancer treatment J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Weiran Cao, Xue Zhang, Rui Li, Zijie Li, An Lu, Fei Yu, Lu Sun, Jiancheng Wang, Zhiyu Wang, Huining He
FOLFOX regimen, composed of folinic acid, 5-fluorouracil (5-FU) and oxaliplatin (OXP), has been used as clinical standard therapeutic regimen in treatments of colorectal cancer (CRC) and esophageal squamous cell carcinoma (ESCC). To further improve its therapeutic outcomes, FOLFOX was combined with anti-PD-1 antibody to form an advanced chemo-immune combination strategy, which has been proven more
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Enhancing gene transfection of poly(β-amino ester)s through modulation of amphiphilicity and chain sequence J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Zhili Li, Rui Guo, Zhiyong Zhang, Haiyang Yong, Lei Guo, Zhengju Chen, Dongdong Huang, Dezhong Zhou
Poly(β-amino ester)s (PAEs) have emerged as a type of highly safe and efficient non-viral DNA delivery vectors. However, the influence of amphiphilicity and chain sequence on DNA transfection efficiency and safety profile remain largely unexplored. In this study, four PAEs with distinct amphiphilicity and chain sequences were synthesized. Results show that both amphiphilicity and chain sequence significantly
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Differentiated mesenchymal stem cells-derived exosomes immobilized in decellularized sciatic nerve hydrogels for peripheral nerve repair J. Control. Release (IF 10.8) Pub Date : 2024-02-21 Bo Liu, Olawale A. Alimi, Yanfei Wang, Yunfan Kong, Mitchell Kuss, Mena Asha Krishnan, Guoku Hu, Yi Xiao, Jixin Dong, Dominick J. DiMaio, Bin Duan
Peripheral nerve injury (PNI) and the limitations of current treatments often result in incomplete sensory and motor function recovery, which significantly impact the patient's quality of life. While exosomes (Exo) derived from stem cells and Schwann cells have shown promise on promoting PNI repair following systemic administration or intraneural injection, achieving effective local and sustained Exo
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E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery J. Control. Release (IF 10.8) Pub Date : 2024-02-20 Yoshimasa Kawaguchi, Yuki Kawamura, Hisaaki Hirose, Megumi Kiyokawa, Momo Hirate, Tsuyoshi Hirata, Yuriko Higuchi, Shiroh Futaki
To facilitate the introduction of proteins, such as antibodies, into cells, a variety of delivery peptides have been engineered. These peptides are typically highly cationic and somewhat hydrophobic, enabling cytosolic protein delivery at the cost of causing cell damage by rupturing membranes. This balance between delivery effectiveness and cytotoxicity presents obstacles for their real-world use.
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Determining topical product bioequivalence with stimulated Raman scattering microscopy J. Control. Release (IF 10.8) Pub Date : 2024-02-19 Fotis Iliopoulos, Dandan Tu, Isaac J. Pence, Xiaolei Li, Priyanka Ghosh, Markham C. Luke, Sam G. Raney, Elena Rantou, Conor L. Evans
Generic drugs are essential for affordable medicine and improving accessibility to treatments. Bioequivalence (BE) is typically demonstrated by assessing a generic product's pharmacokinetics (PK) relative to a reference-listed drug (RLD). Accurately estimating cutaneous PK (cPK) at or near the site of action can be challenging for locally acting topical products. Certain cPK approaches are available
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Rhamnose-PEG-induced supramolecular helices: Addressing challenges of drug solubility and release efficiency in transdermal patch J. Control. Release (IF 10.8) Pub Date : 2024-02-16 Haoyuan Song, Chao Liu, Jiuheng Ruan, Yu Cai, Jiaqi Wang, Xiaoxu Wang, Liang Fang
Transdermal drug delivery systems (TDDS) demand both high drug loading capacity and efficient delivery. In order to improve both simultaneously, this study aims to develop a novel rhamnose-induced pressure-sensitive adhesive (HPR) by dispersing the drug in the supramolecular helical structure. Ten model drugs, categorized as acidic and basic compounds, were chosen to understand the characteristics
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Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. J. Control. Release (IF 10.8) Pub Date : 2024-02-15 Amy Logan, Christopher B. Howard, Pie Huda, Kathleen Kimpton, Zerong Ma, Kristofer J. Thurecht, Joshua A. McCarroll, Ernest Moles, Maria Kavallaris
High-risk neuroblastoma has poor survival due to treatment failure and off-target side effects of therapy. Small molecule inhibitors have shown therapeutic efficacy at targeting oncogenic cell cycle dysregulators, such as polo-like kinase 1 (PLK1). However, their clinical success is limited by a lack of efficacy and specificity, causing off-target toxicity. Herein, we investigate a new treatment strategy
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Near-infrared-responsive CuS@Cu-MOF nanocomposite with high foliar retention and extended persistence for controlling strawberry anthracnose J. Control. Release (IF 10.8) Pub Date : 2024-02-15 Yun Fang, Zhengang Xie, Haonan Zhang, Qiuyu Xiong, Bin Yu, Jingli Cheng, Wenxuan Shang, Jinhao Zhao
Strawberry anthracnose () exhibits a high pathogenicity, capable of directly infecting leaves through natural openings, resulting in devastating impacts on strawberries. Here, nanocomposite (CuS@Cu-MOF) was prepared with a high photothermal conversion efficiency of 35.3% and a strong response to near-infrared light (NIR) by locally growing CuS nanoparticles on the surface of a copper-based metal-organic
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Lipopolymer mediated siRNA delivery targeting aberrant oncogenes for effective therapy of myeloid leukemia in preclinical animal models J. Control. Release (IF 10.8) Pub Date : 2024-02-15 Aysha S. Ansari, Remant K.C., Luis C. Morales, Mohammed Nasrullah, Daniel Nisakar Meenakshi Sundaram, Cezary Kucharski, Xiaoyan Jiang, Joseph Brandwein, Hasan Uludağ
The clinical development of tyrosine kinase inhibitors (TKI) has led to great strides in improving the survival of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) patients. But even the new generation TKIs are rendered futile in the face of evolving landscape of acquired mutations leading to drug resistance, necessitating the pursuit of alternative therapeutic approaches. In contrast
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Locoregional drug delivery for cancer therapy: Preclinical progress and clinical translation J. Control. Release (IF 10.8) Pub Date : 2024-02-14 Suyog Shaha, Danika Rodrigues, Samir Mitragotri
Systemic drug delivery is the current clinically preferred route for cancer therapy. However, challenges associated with tumor localization and off-tumor toxic effects limit the clinical effectiveness of this route. Locoregional drug delivery is an emerging viable alternative to systemic therapies. With the improvement in real-time imaging technologies and tools for direct access to tumor lesions,
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In vivo activation of FAP-cleavable small molecule-drug conjugates for the targeted delivery of camptothecins and tubulin poisons to the tumor microenvironment J. Control. Release (IF 10.8) Pub Date : 2024-02-13 Matilde Bocci, Aureliano Zana, Lucrezia Principi, Laura Lucaroni, Luca Prati, Ettore Gilardoni, Dario Neri, Samuele Cazzamalli, Andrea Galbiati
Small molecule-drug conjugates (SMDCs) are increasingly considered as a therapeutic alternative to antibody-drug conjugates (ADCs) for cancer therapy. OncoFAP is an ultra-high affinity ligand of Fibroblast Activation Protein (FAP), a stromal tumor-associated antigen overexpressed in a wide variety of solid human malignancies. We have recently reported the development of non-internalizing OncoFAP-based
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Metformin-grafted polycaprolactone nanoscaffold targeting sensory nerve controlled fibroblasts reprograming to alleviate epidural fibrosis J. Control. Release (IF 10.8) Pub Date : 2024-02-13 Zeng Xu, Bo Hu, Genjiang Zheng, Wei Yu, Chen Yang, Hui Wang, Keyi Chen, Shatong He, Lei Liang, Chen Xu, Xiaodong Wu, Fazhi Zang, Wei-En Yuan, Huajiang Chen
Epidural fibrosis (EF), associated with various biological factors, is still a major troublesome clinical problem after laminectomy. In the present study, we initially demonstrate that sensory nerves can attenuate fibrogenic progression in EF animal models via the secretion of calcitonin gene-related peptide (CGRP), suggesting a new potential therapeutic target. Further studies showed that CGRP could
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Nano-chemical priming strategy to enhance TGF-β resistance and anti-tumor activity of natural killer cells J. Control. Release (IF 10.8) Pub Date : 2024-02-13 Seung Hee Choi, Hui Bang Cho, Jin-Ho Choi, Hye Jin Kim, Hye Jung Jang, Seohyun Cho, Eunchong Maeng, Hail Park, Ki Seo Ryu, Keun-Hong Park, Kyung-Soon Park
Immunotherapy based on adoptive transfer of natural killer (NK) cells is a promising strategy for circumventing the limitations of cancer treatments. However, components of the immunosuppressive tumor microenvironment (TME), such as transforming growth factor-beta (TGF-β), compromise the therapeutic efficacy of NK cells significantly. To address these limitations, we developed a novel method of engineering
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Next generation therapeutics for retinal neurodegenerative diseases J. Control. Release (IF 10.8) Pub Date : 2024-02-10 Matthew B. Appell, Jahnavi Pejavar, Ashwin Pasupathy, Sri Vishnu Kiran Rompicharla, Saed Abbasi, Kiersten Malmberg, Patricia Kolodziejski, Laura M. Ensign
Neurodegenerative diseases affecting the visual system encompass glaucoma, macular degeneration, retinopathies, and inherited genetic disorders such as retinitis pigmentosa. These ocular pathologies pose a serious burden of visual impairment and blindness worldwide. Current treatment modalities include small molecule drugs, biologics, or gene therapies, most of which are administered topically as eye
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Hyper-spectra imaging analysis of PLGA microspheres via machine learning enhanced Raman spectroscopy J. Control. Release (IF 10.8) Pub Date : 2024-02-09 Minghe Li, Ruifeng Wang, Quanying Bao
Long-acting injectables (LAI) offer a cost-effective and patient-centric approach by reducing pill burden and improving compliance, leading to better treatment outcomes. Among various types of long-acting injectables, poly (lactic--glycolic acid) (PLGA) microspheres have been extensively investigated and reported in the literature. However, microsphere formulation development is still challenging due
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Modular design of cyclic peptide – polymer conjugate nanotubes for delivery and tunable release of anti-cancer drug compounds J. Control. Release (IF 10.8) Pub Date : 2024-02-09 Sophie K. Hill, Richard M. England, Sébastien Perrier
High aspect-ratio nanomaterials have recently emerged as promising drug delivery vehicles due to evidence of strong cellular association and prolonged in vivo circulation times. Cyclic peptide - polymer conjugate nanotubes are excellent candidates due to their elongated morphology, their supramolecular composition and high degree of pliability due to the versatility in manipulating amino acid sequence
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Genetically engineered macrophages as living cell drug carriers for targeted cancer therapy J. Control. Release (IF 10.8) Pub Date : 2024-02-09 Pengbo Ning, Fuyu Du, Haotian Wang, Xiaocheng Gong, Yuqiong Xia, Xianghan Zhang, Hongzhang Deng, Ruili Zhang, Zhongliang Wang
Precise targeting is a major prerequisite for effective cancer therapy because it ensures a sufficient therapeutic dosage in tumors while minimizing off-target side effects. Herein, we report a live-macrophage-based therapeutic system for high-efficiency tumor therapy. As a proof of concept, anti-human epidermal growth factor receptor-2 (HER2) affibodies were genetically engineered onto the extracellular
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Extending dual-targeting upper-limit in liposomal delivery of lithospermic acid B for Alzheimer's mitochondrial revitalization J. Control. Release (IF 10.8) Pub Date : 2024-02-08 Ran Meng, Xiyu Yang, Yixian Li, Qizhi Zhang
Mitochondrial dysfunction is a pivotal event in Alzheimer's disease (AD) pathogenesis. Lithospermic acid B (LA) has shown promise in safeguarding mitochondria, yet the underlying mechanism remains elusive. Here, we present evidence that LA rejuvenated AD-related mitochondrial pool by co-activating mitophagy and mitochondria biogenesis PINK1/LC3B/P62 and PGC-1α/Nrf2. To advance application, hydrophilic
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SiATG5-loaded cancer cell membrane-fused liposomes induced increased uptake of albumin-bound chemotherapeutics by pancreatic cancer cells J. Control. Release (IF 10.8) Pub Date : 2024-02-08 Jing Yan, Miaomiao Wang, Shunli Lv, Dagui Chen, Ziqing Wu, Dongyang Zhou, Shudong Zhang, Jiajing Lv, Ke Xu, Can Xu, Yan Wei
Chemotherapeutic efficacy for pancreatic cancer is severely compromised by limited drug availability to tumor cells. Herein, we constructed a cancer cell membrane-fused liposome containing a siATG5-loaded calcium phosphate (CaP) core, termed CLip@siATG5. Through cancer cell membrane camouflage, the liposomes evaded immune clearance, actively infiltrated tumor tissues, and were preferentially taken
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A microthrombus-driven fixed-point cleaved nanosystem for preventing post-thrombolysis recurrence via inhibiting ferroptosis J. Control. Release (IF 10.8) Pub Date : 2024-02-08 Mengjuan Sun, Chang Liu, Ji Liu, Jing Wen, Tianjiao Hao, Daquan Chen, Yan Shen
Thrombus-induced cardiovascular diseases threaten human health. Current treatment strategies often rely on urokinase plasminogen activator (uPA) for its efficacy, yet it has such limiting factors as short half-life, lack of thrombus targeting, and systemic side effects leading to unintended bleeding. In addition, thrombolytic interventions can trigger inflammation-induced damage at thrombus sites,
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Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer J. Control. Release (IF 10.8) Pub Date : 2024-02-08 Xiang Gong, Chao Zheng, Ying Cai, Wen Zhang, Binyu Zhu, Rong Rong, Ying Kong, Yuan Zhang, Jian Wang, Yaping Li, Pengcheng Zhang
Adenosine (ADO) is a common chemotherapy-associated immune checkpoint that hinders anti-tumor immunity-mediated efficacy of chemotherapy. Herein, we created a synthetic high-density lipoprotein (sHDL) by co-assembly of a doxorubicin (DOX)-apolipoprotein A1 mimetic peptide conjugate, PSB-603 (an A2BR inhibitor), phospholipid, and cholesterol oleate with a microfluidic-based method. The obtained DP-sHDL