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Nucleic acid-based nanogels with “offensive and defensive”effects for enhanced chemo-immunotherapy J. Control. Release (IF 10.5) Pub Date : 2025-06-21 Zijian Zhao, Fei Sun, Wenyu Wang, Bing Li, Yan Liang, Dengshuai Wei, Yong Sun, Jianqin Yan
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High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells J. Control. Release (IF 10.5) Pub Date : 2025-06-20 Jonathan L.F. Lee, Jae Song, Rumelo Amor, Jonathon Bolton, Andrew Thompson, Jürgen Götz, Pranesh Padmanabhan
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Mitochondria-targeted NAD+/O2 co-delivery interpenetrating network hydrogel for respiratory chain restoration and osteoarthritis therapy J. Control. Release (IF 10.5) Pub Date : 2025-06-20 Xiaolong Shen, Jinquan Hu, Chen Wang, Haoyi Wang, Huajian Zhong, Zifan Zhang, Guoqing Wen, Lei Wang, Minjie Dong, Ye Tian
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Nano-golden adjuvant-polymersomes empower tumor photothermal-immunotherapy J. Control. Release (IF 10.5) Pub Date : 2025-06-20 Zhiwei Sun, Jingyi Wang, Beibei Guo, Songsong Zhao, Shiyu Miao, Mingyu Xia, Zhiyuan Zhong, Fenghua Meng
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Programmable chronogenetic gene circuits for self-regulated circadian delivery of biologic drugs J. Control. Release (IF 10.5) Pub Date : 2025-06-18 Amanda Cimino, Fiona Pat, Omolabake Oyebamiji, Lara Pferdehirt, Christine T.N. Pham, Erik D. Herzog, Farshid Guilak
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Homotypic biomimetic nanotheranostics enhance locoregional Cherenkov radiation-induced photodynamic therapy and ferroptosis in early bone metastases J. Control. Release (IF 10.5) Pub Date : 2025-06-20 Rui Xue, Shuai Li, Fengyu Wang, Xiaojing Zou, Beibei Zhang, Chunshui Yu, Qiusong Chen, Jin Wu, Chunyang Sun
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Transdermal delivery of enfuvirtide using dissolving microneedles integrated with novel insertion and removal indicator J. Control. Release (IF 10.5) Pub Date : 2025-06-16 Huanhuan Li, Lalitkumar Vora, Yaocun Li, Anjali Kiran Pandya, Jiawen Wang, Yidan Luo, Abraham M. Abraham, Ester Ballana Guix, Eva Riveira, Maria Nevot, Joseph Houghton, Helen O. McCarthy, Ryan F. Donnelly
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Human Fc CH2 domain modifies cholix transcytosis pathway to facilitate efficient oral therapeutic protein delivery J. Control. Release (IF 10.5) Pub Date : 2025-06-17 Alistair Taverner, Tom Hunter, Julia Mackay, Valentyna Varenko, Kate Gridley, Randall J. Mrsny
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Bone-targeting ZIF-8 based nanoparticles loaded with vancomycin for the treatment of MRSA-induced periprosthetic joint infection J. Control. Release (IF 10.5) Pub Date : 2025-06-17 Shuailong Liang, Yixiao Pan, Jiahao Wang, Zichao Jiang, Tianliang Ma, Sijie Chen, Mingyu Chen, Yinlin Wu, Yi Leng, Yihe Hu, Long Wang
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Targeting and exploiting macropinocytosis in cancer therapy J. Control. Release (IF 10.5) Pub Date : 2025-06-16 Hye-ran Moon, Bo Kyung Cho, Seung Hyun Kang, Ju Hee Ryu, Ick Chan Kwon
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Engineered bacterial extracellular vesicles for gastrointestinal diseases J. Control. Release (IF 10.5) Pub Date : 2025-06-19 Xinke Nie, Qiqiong Li, Ying He, Yushan Xu, Shanfeng Qiao, Xingdong Wang, Fan Meng, Junhua Xie, Shaoping Nie
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Local delivery of IL-12 mRNA and indoximod prodrug potentiates antitumor immunity by increasing T cell effector function J. Control. Release (IF 10.5) Pub Date : 2025-06-18 Heewon Park, In Kang, Susam Lee, Minsa Park, Seungcheol Kim, Su Yeon Lim, Hoyeon Nam, Dohyun Yun, Sejin Kim, Yesol Kim, Ji Hoon Jeong, Kyuri Lee, Heung Kyu Lee, Yong-kyu Lee, Yeu-Chun Kim
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Oxygen self-supplying nanoradiosensitizer activates cGAS-STING pathway to enhance radioimmunotherapy of triple negative breast cancer [Journal of Controlled Release, Volume 376, December 2024, 794–805] J. Control. Release (IF 10.5) Pub Date : 2025-06-16 Xiaofei Wang, Yang Yang, Peng Wang, Qingdong Li, Wenjuan Gao, Yu Sun, Geng Tian, Guilong Zhang, Jianmin Xiao
This is a note of a temporary Expression of Concern related to the above-mentioned publication.
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High-velocity delivery of biologics via the gastrointestinal tract by self-pressurized oral capsules J. Control. Release (IF 10.5) Pub Date : 2025-06-18 Joshua I. Palacios, Amy J. Wood-Yang, Nicholas Klavohn, Nick Friesenhahn, Nisha Raman, Nusaiba Baker, Grant Ashby, Mark R. Prausnitz
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Exosome-based mucosal therapeutic and diagnostic system: towards clinical translation J. Control. Release (IF 10.5) Pub Date : 2025-06-17 Xuyang Liu, Xinze Teng, Jiahao Wang, Gaoshuo Zhang, Wen Guo, Wei Zhang, Qinfu Zhao, Cheng Hu, Li Sun, Yuling Mao
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Posttranslational remodeling micelle reverses cell-surface and exosomal PD-L1 immunosuppression in tumors resistant to PD-L1 antibody therapy J. Control. Release (IF 10.5) Pub Date : 2025-06-14 Xue Shi, Xiejun Zhao, Yinli He, Linpei Zhang, Xinmin Zheng, Xiangchuan Qin, Kefeng Li, Jing Li, Yawen Wang, Liangliang Dai, Xiaojiao Li
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Nanomedicine-mediated macrophage polarization enhances the iron-depleting effect of desferrioxamine for breast cancer immunotherapy J. Control. Release (IF 10.5) Pub Date : 2025-06-16 Shiyu Chen, Weimin Yin, Hui Zhi, Xiaoyou Zhang, Lulu An, Zichen Yang, Rongjie Li, Yanni Cai, Caoyi You, Yan Li, Yongyong Li, Haiqing Dong
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Coordinated modulation of glucose metabolism and immunity via metal-drug nanovesicles for hepatocellular carcinoma therapy J. Control. Release (IF 10.5) Pub Date : 2025-06-16 Mengjie Kong, Liyan Qiu
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Dual-barrier traversing liposomes with ROS-responsive rigidity tuning for oral ischemic stroke therapy J. Control. Release (IF 10.5) Pub Date : 2025-06-15 Jinjie Zhang, Jieke Zhang, Shuo Zhang, Weijing Yang, Wenhui Yang, Jun Guo, Bingxin Sun, Lulu Lv, Jianbo Li
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Syngeneic CAR T cells engineered for persistent delivery of desired proteins J. Control. Release (IF 10.5) Pub Date : 2025-06-14 Sherri L. Newmyer, Harikrishnan Radhakrishnan, Harold S. Javitz, Parijat Bhatnagar
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Polypeptide-protein conjugation: A new paradigm for therapeutic protein delivery J. Control. Release (IF 10.5) Pub Date : 2025-06-11 Xiao Zhang, Shiwei Fu, Bowen Zhao, Yilin Liu, Ronald S. Seruya, Fuwu Zhang
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A biodegradable suction patch for sustainable transbuccal peptide delivery J. Control. Release (IF 10.5) Pub Date : 2025-06-11 Hanna Krupke, Nicole Zoratto, Lucie Rabut, Daniel Gao, Nevena Paunović, David Klein Cerrejon, Benoit Dehapiot, Jean-Christophe Leroux
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A thermoresponsive magnetic nanocarrier with the DNA-mimetic base pairing-guided controlled release of methotrexate in the treatment of rheumatoid arthritis J. Control. Release (IF 10.5) Pub Date : 2025-06-11 Cheng Chen, Qingyun Wei, Zhen Zhu, Wenhui Wu, Tiantian Gong, Yangbo Lv, Aimei Zhang, Chunping Hu, Qichen Zhan, Tao Cao, Peng Cao
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Advanced biomaterials for the targeted delivery of immune checkpoint inhibitors to solid tumors J. Control. Release (IF 10.5) Pub Date : 2025-06-11 Emily M. Henrich, Kevin J. McHugh
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Oral delivery of tunable oxidation-responsive budesonide-loaded nanoparticles enhances inflammation modulation in intestinal colitis J. Control. Release (IF 10.5) Pub Date : 2025-06-11 Cecília Cristelo, Juliana Viegas, Andreia S. Barros, Helena Almeida, José das Neves, Bruno Sarmento, Rute Nunes
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Impact of ionizable lipid type on the pharmacokinetics and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection J. Control. Release (IF 10.5) Pub Date : 2025-06-10 Yuxiang Ren, Lihuan Lin, Mohammad Abdallah, Xueting Zhu, Haiyin Liu, Stewart A. Fabb, Thomas J. Payne, Colin W. Pouton, Angus P.R. Johnston, Natalie L. Trevaskis
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Novel biomarker discovery-coupled plasma therapy with enhanced tumor penetration for non-surgical treatment of cervical cancer J. Control. Release (IF 10.5) Pub Date : 2025-06-10 Sung Wook Kim, Min-Jung Kang, Young Sun Kim, Woo Yeon Hwang, Aram Lee, Quoc-Viet Le, Ihn Han, Min Hyung Jung, Kiyong Na, Kyung Sook Kim, Sung Jong Lee, Dong Soo Suh, Ki Hyung Kim, Kyung Un Choi, Eun Ha Choi, Gayong Shim, Jongmin Kim, Byung Su Kwon
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Bacteriophage lysin-MOFs nanomaterials for treating apical periodontitis J. Control. Release (IF 10.5) Pub Date : 2025-06-10 Manhong Kuong, Haiping Wang, Feifei Han, Limei Fan, Fangfang Yao, Kai Yang, Xiaoying Hou, Zhengkai Li, Wanting He, Xiji Shu, Binlian Sun, Yuchen Liu, Yuhong Li
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Targeting ferroptosis and mitophagy with neutrophil-inspired nanozyme for Parkinson's disease therapy J. Control. Release (IF 10.5) Pub Date : 2025-06-10 Yu Tian, Feng Wang, Jing Ma, Wei Huang, Xiaodan Zhang, Chengzhong Du, Penghui Wei, Wen Huang, Yang Zhu, Yuanxiang Lin
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Affinity-based controlled release of interleukin-4 from scaffolds via biotin-streptavidin interactions for immunomodulation J. Control. Release (IF 10.5) Pub Date : 2025-06-09 Victoria A. Nash, Juan F. Cortes-Troncoso, Phoebe E. Chua, Kara L. Spiller
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Lyophilized SARS-CoV-2 self-amplifying RNA vaccines for microneedle Array patch delivery J. Control. Release (IF 10.5) Pub Date : 2025-06-09 Madison M. Driskill, Ian A. Coates, Paul J. Hurst, Netra U. Rajesh, Maria T. Dulay, Robert M. Waymouth, Wataru Akahata, Kenta Matsuda, Jonathan F. Smith, Gunilla B. Jacobson, Jillian L. Perry, Shaomin Tian, Joseph M. DeSimone
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A cGAS-STING pathway activating cobalt(III) cyclam prodrug for combined chemotherapy and immunotherapy of breast cancer J. Control. Release (IF 10.5) Pub Date : 2025-06-09 Haiqin Song, Nicolás Montesdeoca, Elizaveta Efanova, Xuan Li, Johannes Karges, Haihua Xiao, Kun Shang, Hanchen Zhang
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Self-assembled copper chlorogenic acid nanoparticles: Inducing pyroptosis and cuproptosis to activate antitumor immunity J. Control. Release (IF 10.5) Pub Date : 2025-06-09 Yuxin Zhou, Qian Wang, Qian Wang, Ziyi Zhou, Xiaoyang Peng, Botao Qu, Ruiping Zhang
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Advances in near-infrared responsive functional nanocomposites for bioimaging and antitumor research J. Control. Release (IF 10.5) Pub Date : 2025-06-09 Juan Wang, Xing Gao, Lei Feng, Deliang Zhang, Shuhua Lv, Xiaoyin Li, Qingjia Liu, Dongkun Yu, Miaomiao Xing, Dongrun Li, Lulu Suo, Hongyu Mou, Jibin Song
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Corrigendum to “‘Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit ‘ferroptosis storm’ and modulate immune targeting for acute kidney injury” [Journal of Controlled Release 379 (2025) 59–76] J. Control. Release (IF 10.5) Pub Date : 2025-06-09 Yuxin Cao, Xiaowei Liu, Chunjing Guo, Weili Yang, Xuemei Wang, Xinxin Wang, Haiyu Xu, Wenming Wang, Dandan Liu, Jingwen Zhang, Wenhao Cui, Yuxiu Chen, Xuan Guo, Daquan Chen
The authors regret that an error occurred in Fig. S23 (FPPF@Cur group, Lung) in the Supplementary material. Please find the corrected image below. The authors state that the corrections do not change the conclusions of this work. Download: Download high-res image (756KB) Download: Download full-size image
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Multifunctional delivery strategies and nanoplatforms of SN-38 in cancer therapeutics J. Control. Release (IF 10.5) Pub Date : 2025-06-07 Mercedes Lozano-García, Emre Dikici, Daniel Bilbao, Prasoon Mohan, Sapna Deo, Sylvia Daunert
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Intravitreal injection of cell membrane-coated nanoparticles for retinoblastoma treatment J. Control. Release (IF 10.5) Pub Date : 2025-06-06 Yichi Zhang, Kaiqi Long, Ka Yi Lee, Jia Li, Shuting Xu, Kang Chen, Xi Chen, Qingyi Dai, Yifan Lin, Changyou Zhan, Weiping Wang
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Advanced rational design of polymeric nanoparticles for the controlled delivery of biologics J. Control. Release (IF 10.5) Pub Date : 2025-06-06 J. Jesus Rodriguez-Cruz, Fabiola A. Chapa-Villarreal, Ishaan Duggal, Nicholas A. Peppas
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Multimodal nanoparticles co-delivering bevacizumab and dichloroacetate for dual targeting of neoangiogenesis and hyperglycolysis in glioblastoma treatment J. Control. Release (IF 10.5) Pub Date : 2025-06-06 Catarina Pacheco, Olaya de Dios, Maria Angeles Ramiréz-González, Cláudia Martins, Sílvia L. Fialho, Fátima Baltazar, Bruno M. Costa, Pilar Sánchez-Gómez, Bruno Sarmento
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Optimizing delivery in a multivalent subunit influenza vaccine using mixed polymeric microparticle degradation rates J. Control. Release (IF 10.5) Pub Date : 2025-06-06 Erik S. Pena, Luis Ontiveros-Padilla, Nicole R. Lukesh, Grace L. Williamson, Connor T. Murphy, Dylan A. Hendy, John A. Roque III, Michael A. Carlock, Ted M. Ross, Kristy M. Ainslie, Eric M. Bachelder
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Targeted delivery of engineered extracellular vesicles to simultaneously promote vascularization and muscle regeneration in ischemic limbs J. Control. Release (IF 10.5) Pub Date : 2025-06-06 Ting Zhong, Ning Gao, Hong Niu, Ya Guan, Jiaxing Wen, Zhongting Liu, Jianjun Guan
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Antibody-mediated ratiometric delivery of FLT3 and CDK4/6 dual inhibitors for targeted treatment of acute myeloid leukemia J. Control. Release (IF 10.5) Pub Date : 2025-06-06 Zhenzhen Zhai, Chenming Li, Lin Chen, Yan Zhao, Xueling Tang, Li Cao, Huanli Sun, Zhiyuan Zhong
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Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery J. Control. Release (IF 10.5) Pub Date : 2025-06-05 Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Xueying Liu, Panyue Wen, Shigeto Fukushima, Kazunori Kataoka
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Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors J. Control. Release (IF 10.5) Pub Date : 2025-06-04 Yuto Honda, Haruna Haraguchi, Takeru Tsuda, Rui Ko, Kyohei Muguruma, Haochen Guo, Takahiro Nomoto, Yutaka Miura, Nobuhiro Nishiyama
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ATRA derived lipid nanoparticles for co-delivery of siCYP26A1 to overcome metabolic limitations of differentiation therapy in solid tumors J. Control. Release (IF 10.5) Pub Date : 2025-06-04 Huan Yang, Yiyao Pu, Xueyi Hu, Haili Zhang, Shiyi Li, Wei Zhang, Meiwan Chen, Heyang Zhang, Rongrong Jin, Yu Nie
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Designing and modeling nanomedicines towards image-guided drug delivery in hematological malignancies J. Control. Release (IF 10.5) Pub Date : 2025-06-04 Shiva Khorshid, Julian Baumeister, Federica De Lorenzi, Mattia Tiboni, Sara Elsafy, Alessandro Motta, Alessia Nucci, Saskia von Stillfried, Nicolas Chatain, Fabian Kiessling, Steffen Koschmieder, Twan Lammers, Luca Casettari, Alexandros Marios Sofias
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Tailored regulation of ferroptosis in periodontitis using thermosensitive ionic liquid hydrogel based on galangin/L-cysteine-decorated MoS2 nanoflowers J. Control. Release (IF 10.5) Pub Date : 2025-06-04 Maomao Tang, Rui Ma, Yang Ding, Yachen Fei, Yuxiao Wang, Guichun Wang, Chendong Zhang, Yuan Chen, Xianglian Dong, Peng Chen, Heng Li, Huanhuan Liu, Chengjun Peng, Jian Guo, Shuangying Gui
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Clinically relevant dosing of miR-145 micelles curbs atherosclerosis in vivo J. Control. Release (IF 10.5) Pub Date : 2025-06-04 Isabella Suzuki, Anisa Ashraf, Neil Patel, Yi Huang, Brian Lam, Dawon Kim, Auveen Choroomi, Avery Liu, Kyla Johnson, Christopher Williams, Julia Chang, Shino Magaki, Harry Vinters, Eun Ji Chung
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Drug and therapeutic intravaginal delivery targeting diseases in the female reproductive tract: A mathematical modeling perspective J. Control. Release (IF 10.5) Pub Date : 2025-06-02 Bassam Fotouh, Anthony J. Kyser, Hermann B. Frieboes
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Effective head and neck cancer treatment combines radiation and local extended cisplatin release J. Control. Release (IF 10.5) Pub Date : 2025-06-02 Narmeen Daher-Ghanem, Shell Raveh, Awanish Kumar, Ariel M. Rubinstein, Hadas Solgi, Shay Sharon, Jawad Abu Tair, Yoram Fleissig, Jon Feldman, Yakir Rottenberg, Aron Popovtzer, Peter Siman, Abraham J. Domb, Nataly Kravchenko-Balasha
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Impact of tail unsaturation in ionizable lipids on mRNA delivery efficiency and immunogenicity of lipid nanoparticles J. Control. Release (IF 10.5) Pub Date : 2025-06-01 Xueer Ge, Zepeng He, Haihong Yang, Xiaorong Pan, Liang Yan, Yi Shi, Yongming Chen, Zhijia Liu
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Monocyte membrane-coated drug nanocrystals for enhanced targeted therapy of rheumatoid arthritis J. Control. Release (IF 10.5) Pub Date : 2025-06-01 Rongying Shi, Jiali Fu, Min Li, Anqi Zhang, Shiyun Huang, Xueying Yang, Yi Liang, Yuan Quan, Shanshan He, Shiqi Huang, Lin Li, Xun Sun, Tao Gong, Ling Zhang, Qing Lin, Zhirong Zhang
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Harnessing RGDS peptides to regulate bacterial-host interfaces for targeted antimicrobial therapy J. Control. Release (IF 10.5) Pub Date : 2025-06-01 Yuting Feng, Wenyue Xie, Zhuo Wan, Ying Jiang, Hongwei Xu, Jianan Qu, Zhuoling Tian, Yaqian Liu, Xiaoye Liu, Zuoying Yuan, Siying Qin, Chunyang Xiong, Jianyong Huang
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Immune regulation and repair of osteochondral defects using manganese-luteolin hydrogel scaffold J. Control. Release (IF 10.5) Pub Date : 2025-05-30 Shuai Yuan, Haobo Li, Zhengyang Xu, Zhipeng Yue, Shu Chen, Qiwei Fu, Yi Chen
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Hypoxia-sensitive macrocycle inclusion complexes for targeted protein degradation J. Control. Release (IF 10.5) Pub Date : 2025-05-30 Jiachan Lin, Wenyan Wang, An-Kang Ying, Zirui Chen, Dan Zhang, Chendi Ding, Xiaowei Zeng, Dong-Sheng Guo, Hongzhong Chen
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Microneedle-mediated biomimetic nanoparticles for targeted antioxidant and anti-inflammatory therapy in age-related macular degeneration J. Control. Release (IF 10.5) Pub Date : 2025-05-30 Jiaxin Liu, Jing Hu, Yang Li, Narisu Hu, Yihua Wang, Baiyu Chang, Yiyuan Guo, Xiaoyang Li, Qing Zhang, Yan Ming, Congcong Lin, Hongyu Ji, Zhenlei Yang, Jingling Tang
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Topical delivery of cultivated limbal stem cells via porous photocurable hydrogel: A noninvasive, convenient, and efficient stem cells delivery strategy for limbal stem cell deficiency J. Control. Release (IF 10.5) Pub Date : 2025-05-30 Shujia Guo, Yi Han, Jiani Li, Yuhan Huang, Dong Yu, Yuwen Liu, Yuqian Wang, Chaoyu Fan, Yimin Huang, Wenyin Guan, Danyi Qin, Lan Zheng, Caihong Huang, Cheng Li, Jiaoyue Hu, Zuguo Liu
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Functional lipid nanoparticles for safe delivery of macromolecular antibiotics to gram-negative bacteria J. Control. Release (IF 10.5) Pub Date : 2025-05-30 Melgious J.Y. Ang, Nithiyaa Balakrishnan, Ki Hyun Bae, Qiangqiang Wang, Zhengjie Wu, Yanming Wang, Pinzheng Zhang, Brandon Y.L. Seow, Xiaoli Liu, Yi Yan Yang
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Injectable hydrogel-based drug formulation for enhancing tertiary lymphoid structure formation and cancer immunotherapy efficacy J. Control. Release (IF 10.5) Pub Date : 2025-05-29 Chaiyaporn Kuwentrai, Weilong Tang, Xuansheng Lin, Teng Chi, Dongping Liu, Erwei Song, Matthew J. Webber, Jian-Dong Huang, Zhou Ye
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Self-enhanced ROS-responsive camptothecin prodrug nanoparticles elicit safe and efficient intravesical instillation therapy of bladder cancer J. Control. Release (IF 10.5) Pub Date : 2025-05-29 Kunpeng Liu, Binbin Jiao, Guan Zhang, Zhihua Gan, Shicong Lai, Zhenshan Ding, Qingsong Yu
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