Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-09-12
Srdjan Sumarac, Jinyoung Youn, Conor Fearon, Luka Zivkovic, Prerana Keerthi, Oliver Flouty, Milos Popovic, Mojgan Hodaie, Suneil Kalia, Andres Lozano, William Hutchison, Alfonso Fasano, Luka Milosevic
GPR37 processing in neurodegeneration: a potential marker for Parkinson’s Disease progression rate
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-09-10
Josep Argerich, Leonardo D. Garma, Marc López-Cano, Paula Álvarez-Montoya, Laura Gómez-Acero, Víctor Fernández-Dueñas, Ana B. Muñoz-Manchado, Ester Aso, Adam Boxer, Pol Andres-Benito, Per Svenningsson, Francisco Ciruela
Uric acid and alterations of purine recycling disorders in Parkinson’s disease: a cross-sectional study
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-09-09
Sayuri Shima, Yasuaki Mizutani, Junichiro Yoshimoto, Yasuhiro Maeda, Reiko Ohdake, Ryunosuke Nagao, Toshiki Maeda, Atsuhiro Higashi, Akihiro Ueda, Mizuki Ito, Tatsuro Mutoh, Hirohisa Watanabe
Identifying potential causal effects of Parkinson’s disease: A polygenic risk score-based phenome-wide association and mendelian randomization study in UK Biobank
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-09-06
Changhe Shi, Dongrui Ma, Mengjie Li, Zhiyun Wang, Chenwei Hao, Yuanyuan Liang, Yanmei Feng, Zhengwei Hu, Xiaoyan Hao, Mengnan Guo, Shuangjie Li, Chunyan Zuo, Yuemeng Sun, Mibo Tang, Chengyuan Mao, Chan Zhang, Yuming Xu, Shilei Sun
Neural correlates of bradykinesia in Parkinson’s disease: a kinematic and functional MRI study
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-09-06
Elisabetta Sarasso, Andrea Gardoni, Lucia Zenere, Daniele Emedoli, Roberta Balestrino, Andrea Grassi, Silvia Basaia, Chiara Tripodi, Elisa Canu, Massimo Malcangi, Elisa Pelosin, Maria Antonietta Volontè, Davide Corbetta, Massimo Filippi, Federica Agosta
Parkinson’s disease is associated with clonal hematopoiesis with TET2 mutation
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-09-06
Kyung Ah Woo, Han-Joon Kim, Chan Young Lee, Jung Hwan Shin, Choonghyun Sun, Hogune Im, Hongyul An, Jiwoo Lim, Su-Yeon Choi, Youngil Koh, Beomseok Jeon
Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-09-02
Natalia López-González del Rey, Nagore Hernández-Pinedo, Megan Carrillo, María del Cerro, Noelia Esteban-García, Inés Trigo-Damas, Mariana H. G. Monje, José L. Lanciego, Carmen Cavada, José A. Obeso, Javier Blesa
Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-22
K. N. Rose, M. Zorlu, A. Fassini, H. Lee, W. Cai, X. Xue, S. Lin, P. Kivisakk, M. A. Schwarzschild, X. Chen, S. N. Gomperts
MRI subtypes in Parkinson’s disease across diverse populations and clustering approaches
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-16
Anna Inguanzo, Rosaleena Mohanty, Konstantinos Poulakis, Daniel Ferreira, Barbara Segura, Franziska Albrecht, J-Sebastian Muehlboeck, Tobias Granberg, Henrik Sjöström, Per Svenningsson, Erika Franzén, Carme Junqué, Eric Westman
Loss-of-function variants in ITSN1 confer high risk of Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-15
Astros Th. Skuladottir, Vinicius Tragante, Gardar Sveinbjornsson, Hannes Helgason, Arni Sturluson, Anna Bjornsdottir, Palmi Jonsson, Vala Palmadottir, Olafur A. Sveinsson, Brynjar O. Jensson, Sigurjon A. Gudjonsson, Erna V. Ivarsdottir, Rosa S. Gisladottir, Arni F. Gunnarsson, G. Bragi Walters, Gudrun A. Jonsdottir, Thorgeir E. Thorgeirsson, Gyda Bjornsdottir, Hilma Holm, Daniel F. Gudbjartsson, Patrick
CSF markers of neurodegeneration Alzheimer’s and Lewy body pathology in isolated REM sleep behavior disorder
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-15
Amaia Muñoz-Lopetegi, Simone Baiardi, Mircea Balasa, Angela Mammana, Gerard Mayà, Marcello Rossi, Mónica Serradell, Corrado Zenesini, Alice Ticca, Joan Santamaria, Sofia Dellavalle, Carles Gaig, Alex Iranzo, Piero Parchi
Diagnostic accuracy and predictors of alpha-synuclein accumulation in the gastrointestinal tract of Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-15
Chaewon Shin, Seong-Ik Kim, Sung-Hye Park, Jong-Min Kim, Jee-Young Lee, Sun Ju Chung, Jae Woo Kim, Tae-Beom Ahn, Kye Won Park, Jung Hwan Shin, Chan Young Lee, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Han-Joon Kim, Han-Kwang Yang, Beomseok Jeon
Risk willingness in multiple system atrophy and Parkinson’s disease understanding patient preferences
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-15
Alexander Maximilian Bernhardt, Marc Oeller, Isabel Friedrich, Emre Kocakavuk, Eliana Nachman, Kevin Peikert, Malte Roderigo, Andreas Rossmann, Tabea Schröter, Lea Olivia Wilhelm, Tino Prell, Christoph van Riesen, Johanna Nieweler, Sabrina Katzdobler, Markus Weiler, Heike Jacobi, Tobias Warnecke, Inga Claus, Carla Palleis, Stephan Breimann, Björn Falkenburger, Moritz Brandt, Andreas Hermann, Jost-Julian
Standardized wireless deep brain stimulation system for mice
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-14
Alexander Grotemeyer, Tobias Petschner, Robert Peach, Dirk Hoehl, Torsten Knauer, Uwe Thomas, Heinz Endres, Robert Blum, Michael Sendtner, Jens Volkmann, Chi Wang Ip
A worldwide study of white matter microstructural alterations in people living with Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-11
Conor Owens-Walton, Talia M. Nir, Sarah Al-Bachari, Sonia Ambrogi, Tim J. Anderson, Ítalo Karmann Aventurato, Fernando Cendes, Yao-Liang Chen, Valentina Ciullo, Phil Cook, John C. Dalrymple-Alford, Michiel F. Dirkx, Jason Druzgal, Hedley C. A. Emsley, Rachel Guimarães, Hamied A. Haroon, Rick C. Helmich, Michele T. Hu, Martin E. Johansson, Ho Bin Kim, Johannes C. Klein, Max Laansma, Katherine E. Lawrence
Comparison of beta peak detection algorithms for data-driven deep brain stimulation programming strategies in Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-09
Sunderland K. Baker, Erin M. Radcliffe, Daniel R. Kramer, Steven Ojemann, Michelle Case, Caleb Zarns, Abbey Holt-Becker, Robert S. Raike, Alexander J. Baumgartner, Drew S. Kern, John A. Thompson
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-06
Baihui Cao, Xiaotong Chen, Yubin Li, Tian Zhou, Nuo Chen, Yaxin Guo, Ming Zhao, Chun Guo, Yongyu Shi, Qun Wang, Xuexiang Du, Lining Zhang, Yan Li
GBA-AAV mitigates sleep disruptions and motor deficits in mice with REM sleep behavior disorder
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-08-02
Ying Chen, Wei-Ye Xie, Dong Xia, Mu-Tian Zhang, Yan-Rui Sun, Wen-Xiang Duan, Yun Shen, Fen Wang, Wei-Min Qu, Zhi-Li Huang, Chun-Feng Liu
Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-07-31
Keita Hiraga, Makoto Hattori, Yuki Satake, Daigo Tamakoshi, Taiki Fukushima, Takashi Uematsu, Takashi Tsuboi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Yukihiko Washimi, Akihiro Hori, Masayuki Yamamoto, Hideaki Shimizu, Masakazu Wakai, Harutsugu Tatebe, Takahiko Tokuda, Akinori Nakamura, Shumpei Niida, Masahisa Katsuno
Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-07-29
Janni Nielsen, Johanne Lauritsen, Jannik N. Pedersen, Jan S. Nowak, Malthe K. Bendtsen, Giulia Kleijwegt, Kaija Lusser, Laia C. Pitarch, Julián V. Moreno, Matthias M. Schneider, Georg Krainer, Louise Goksøyr, Paul Khalifé, Sanne Simone Kaalund, Susana Aznar, Magnus Kjærgaard, Vita Sereikaité, Kristian Strømgaard, Tuomas P. J. Knowles, Morten Agertoug Nielsen, Adam F. Sander, Marina Romero-Ramos, Daniel
Human tripartite cortical network model for temporal assessment of alpha-synuclein aggregation and propagation in Parkinson’s Disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-07-28
Fikret Emre Kapucu, Iisa Tujula, Oskari Kulta, Lassi Sukki, Tomi Ryynänen, Hjalte Gram, Valtteri Vuolanto, Andrey Vinogradov, Joose Kreutzer, Poul Henning Jensen, Pasi Kallio, Susanna Narkilahti
Comprehensive real time remote monitoring for Parkinson’s disease using Quantitative DigitoGraphy
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-07-27
Shannon L. Hoffman, Paul Schmiedmayer, Aryaman S. Gala, Kevin B. Wilkins, Laura Parisi, Shreesh Karjagi, Aarushi S. Negi, Simon Revlock, Christopher Coriz, Jeremy Revlock, Vishnu Ravi, Helen Bronte-Stewart
Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-07-26
Pilar Alvarez Jerez, Kensuke Daida, Francis P. Grenn, Laksh Malik, Abigail Miano-Burkhardt, Mary B. Makarious, Jinhui Ding, J. Raphael Gibbs, Anni Moore, Xylena Reed, Mike A. Nalls, Syed Shah, Medhat Mahmoud, Fritz J. Sedlazeck, Egor Dolzhenko, Morgan Park, Hirotaka Iwaki, Bradford Casey, Mina Ryten, Cornelis Blauwendraat, Andrew B. Singleton, Kimberley J. Billingsley
High-depth whole-genome sequencing identifies structure variants, copy number variants and short tandem repeats associated with Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-07-23
Chaodong Wang, Hankui Liu, Xu-Ying Li, Jinghong Ma, Zhuqin Gu, Xiuli Feng, Shu Xie, Bei-Sha Tang, Shengdi Chen, Wei Wang, Jian Wang, Jianguo Zhang, Piu Chan
Metabolic profiling reveals circulating biomarkers associated with incident and prevalent Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-07-09
Wenyi Hu, Wei Wang, Huan Liao, Gabriella Bulloch, Xiayin Zhang, Xianwen Shang, Yu Huang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He, Zhuoting Zhu
A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-07-04
Yaoyun Kuang, Hengxu Mao, Tingting Gan, Wenyuan Guo, Wei Dai, Weimeng Huang, Zhuohua Wu, Hongyan Li, Xiaoyun Huang, Xinling Yang, Ping-Yi Xu
Analysis of striatal connectivity corresponding to striosomes and matrix in de novo Parkinson’s disease and isolated REM behavior disorder
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-06-25
S. Marecek, T. Krajca, R. Krupicka, P. Sojka, J. Nepozitek, Z. Varga, C. Mala, J. Keller, J. L. Waugh, D. Zogala, J. Trnka, K. Sonka, E. Ruzicka, P. Dusek
Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-06-21
Xi Zhang, Linhao Ruan, Hu Wang, Jin Zhu, Taibo Li, Gordon Sun, Yi Dong, Yuhao Wang, Gil Berreby, Ashley Shay, Rong Chen, Sreekumar Ramachandran, Valina L. Dawson, Ted M. Dawson, Rong Li
Understanding the role of cerebellum in early Parkinson’s disease: a structural and functional MRI study
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-06-19
S. Pietracupa, A. Ojha, D. Belvisi, C. Piervincenzi, S. Tommasin, N. Petsas, M. I. De Bartolo, M. Costanzo, A. Fabbrini, A. Conte, A. Berardelli, P. Pantano
Subthalamic nucleus input-output dynamics are correlated with Parkinson’s burden and treatment efficacy
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-06-15
Xiaowei Liu, Jing Guang, Stefanie Glowinsky, Hodaya Abadi, David Arkadir, Eduard Linetsky, Muneer Abu Snineh, Juan F. León, Zvi Israel, Wei Wang, Hagai Bergman
Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-06-15
Ilaria Linda Dellarole, Elena Vacchi, Inigo Ruiz-Barrio, Sandra Pinton, Andrea Raimondi, Stefania Rossi, Sara Morandi, Giovanni Bianco, Merve Begum Bacinoglu, Annalisa Lombardo, Luigi Celauro, Claudio Staedler, Salvatore Galati, Javier Pagonabarraga, Jaime Kulisevsky, Giuseppe Legname, Claudio Gobbi, Alain Kaelin-Lang, Fabio Moda, Giorgia Melli
Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study over 12 months
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-06-12
Jamie L. Adams, Tairmae Kangarloo, Yishu Gong, Vahe Khachadourian, Brian Tracey, Dmitri Volfson, Robert D. Latzman, Joshua Cosman, Jeremy Edgerton, David Anderson, Allen Best, Melissa A. Kostrzebski, Peggy Auinger, Peter Wilmot, Yvonne Pohlson, Stella Jensen-Roberts, Martijn L. T. M. Müller, Diane Stephenson, E. Ray Dorsey
Predictors of short-term anxiety outcome in subthalamic stimulation for Parkinson’s disease
npj Parkinsons Dis.
(IF 6.7 )
Pub Date : 2024-06-08
Anna Sauerbier, Johanna Herberg, Vasilija Stopic, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Stefanie T. Jost, Jan Niklas Petry-Schmelzer, Alexandra Gronostay, Christian Schneider, Veerle Visser-Vandewalle, Julian Evans, Christopher Nimsky, Gereon R. Fink, Angelo Antonini, Pablo Martinez-Martin, Monty Silverdale, Daniel Weintraub, Anette Schrag, K. Ray Chaudhuri, Lars Timmermann, Haidar
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