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Aberrant Functional Connectivity and Brain Network Organization in High-Schizotypy Individuals: An Electroencephalography Study Schizophr. Bull. (IF 5.3) Pub Date : 2025-02-04 Jelena Trajkovic, Giulia Ricci, Gabriele Pirazzini, Luca Tarasi, Francesco Di Gregorio, Elisa Magosso, Mauro Ursino, Vincenzo Romei
Background and Hypothesis Oscillatory synchrony plays a crucial role in establishing functional connectivity across distinct brain regions. Within the realm of schizophrenia, suggested to be a neuropsychiatric disconnection syndrome, discernible aberrations arise in the organization of brain networks. We aim to investigate whether the resting-state functional network is already altered in healthy individuals
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Cognitive Impairment in Psychotic Disorders Is Associated with Brain Reductive Stress and Impaired Energy Metabolism as Measured by 31P Magnetic Resonance Spectroscopy Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-27 Virginie-Anne Chouinard, Fei Du, Xi Chen, Emma Tusuzian, Boyu Ren, Jacey Anderson, Kyle Cuklanz, Wirya Feizi, Shuqin Zhou, Akila Weerasekera, Bruce M Cohen, Dost Öngür, Kathryn E Lewandowski
Background and Hypothesis Convergent evidence shows the presence of brain metabolic abnormalities in psychotic disorders. This study examined brain reductive stress and energy metabolism in people with psychotic disorders with impaired or average range cognition. We hypothesized that global cognitive impairment would be associated with greater brain metabolic dysregulation. Study Design Participants
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Altered Effective Connectivity Within a Thalamocortical Corollary Discharge Network in Individuals With Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-24 Matthew Lehet, Beier Yao, Ivy F Tso, Vaibhav A Diwadkar, Jessica Fattal, Jacqueline Bao, Katharine N Thakkar
Background and Hypothesis Sequential saccade planning requires corollary discharge (CD) signals that provide information about the planned landing location of an eye movement. These CD signals may be altered among individuals with schizophrenia (SZ), providing a potential mechanism to explain passivity and anomalous self-experiences broadly. In healthy controls (HC), a key oculomotor CD network transmits
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Delusional Themes are More Varied Than Previously Assumed: A Comprehensive Systematic Review and Meta-Analysis Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-23 Elisavet Pappa, Fidelia Baah, Jessica Lynch, Lisha Shiel, Graham Blackman, Nichola Raihani, Vaughan Bell
Background and Hypothesis Delusions are classified into themes but the range of themes reported in the literature has never been examined and the extent to which they differ in prevalence, or relate to clinical characteristics or cultural variation, remains poorly understood. Study Design We identified studies reporting delusional theme prevalence in adults with psychosis and completed two multivariate
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Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-22 Wenjing Zhang, Changjian Qiu, Su Lui
Background and Hypothesis Identifying biomarkers at onset and specifying the progression over the early course of schizophrenia is critical for better understanding of illness pathophysiology and providing novel information relevant to illness prognosis and treatment selection. Studies of antipsychotic-naïve first-episode schizophrenia in China are making contributions to this goal. Study Design A
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Deciding to Be Left Alone After Being Left Out: Behavioral Responses to Social Exclusion in Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-22 Lauren P Weittenhiller, Ann M Kring
Background and Hypotheses People with schizophrenia are at risk for social exclusion, yet we know little about their responses. We hypothesized (1) people with schizophrenia would be more likely to withdraw following social exclusion compared to controls; (2) withdrawal intentions would be greater following exclusion compared to disappointment; (3) withdrawal behavior would be predicted by rejection
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Trajectories of Resilience-Related Traits and Their Impact on Health Outcomes in Schizophrenia: Results From a 4-Year Longitudinal Study Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-09 Ellen E Lee, Tsung-Chin Wu, Stephanie Ibrahim, Angelina Van Dyne, Xin M Tu, Lisa T Eyler
Background and Hypothesis For the rapidly growing population of older people living with schizophrenia (PLWS), psychological resilience, or the capacity to adapt to adversity, is an understudied target for improving health. Little is known about resilience and its longitudinal impact on outcomes among PLWS. This study assesses trajectories of resilience-related traits in PLWS and a nonpsychiatric comparison
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Blunted Ventral Striatal Reactivity to Social Reward Is Associated with More Severe Motivation and Pleasure Deficits in Psychosis Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-09 Alexander J Shackman, Jason F Smith, Ryan D Orth, Christina L G Savage, Paige R Didier, Julie M McCarthy, Melanie E Bennett, Jack J Blanchard
Background and Hypothesis Among individuals living with psychotic disorders, social impairment is common, debilitating, and challenging to treat. While the roots of this impairment are undoubtedly complex, converging lines of evidence suggest that social motivation and pleasure (MAP) deficits play a central role. Yet most neuroimaging studies have focused on monetary rewards, precluding decisive inferences
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Evaluating the Exposome Score for Schizophrenia in a Transdiagnostic Psychosis Cohort: Associations With Psychosis Risk, Symptom Severity, and Personality Traits Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-08 Bryan Kromenacker, Walid Yassin, Matcheri Keshavan, David Parker, Vishal J Thakkar, Godfrey Pearlson, Sarah Keedy, Jennifer McDowell, Elliot Gershon, Elena Ivleva, S Kristian Hill, Brett A Clementz, Carol A Tamminga
Background Investigations of causal pathways for psychosis can be guided by the identification of environmental risk factors. A recently developed composite risk tool, the exposome score for schizophrenia (ES-SCZ), which controls for intercorrelations between risk factors, has shown fair to good performance. We tested the transdiagnostic psychosis classifier performance of the ES-SCZ with the Bipolar-Schizophrenia
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Aberrant Cortical Morphological Networks in First-Episode Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-06 Fengmei Fan, Suhui Jin, Yating Lv, Shuping Tan, Yuqing Liao, Zhenzhen Luo, Jingxuan Ruan, Zhiren Wang, Hongzhen Fan, Xiaole Han, Qihong Zou, Hong Xiang, Hua Guo, Fude Yang, Yunlong Tan, Jinhui Wang
Background and Hypothesis Population-based morphological covariance networks are widely reported to be altered in schizophrenia. Individualized morphological brain network approaches have emerged recently. We hypothesize that individualized morphological brain networks are disrupted in schizophrenia. Study Design We constructed single-subject morphological brain networks for 203 patients with first-episode
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Schizophrenia Following Early Adolescence Prodrome: A Neurodevelopmental Subtype With Autism-like Sensorimotor and Social Cognition Deficits Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-06 Anton Iftimovici, Gilles Martinez, Julie Victor, Narjès Bendjemaa, Célia Jantac, Charlotte Danset-Alexandre, Isabelle Amado, Laura Pina-Camacho, Boris Chaumette, Mar Fatjó-Vilas, Lourdes Fañanás, Edouard Duchesnay, Marie-Odile Krebs
Background and Hypothesis While age at onset in schizophrenia (SCZ) is usually defined by age at onset of psychosis, the illness actually occurs earlier, with a prodrome often starting in childhood or adolescence. We postulated that SCZ with early-adolescence prodromes (SCZ-eaP) presents with social cognition deficits and sensorimotor impairments more similar to autism spectrum disorders (ASD) than
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The Role of Fatty Acid Amide Hydrolase, a Key Regulatory Endocannabinoid Enzyme, in Domain-Specific Cognitive Performance in Psychosis Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-27 Ana Weidenauer, Ranjini Garani, Nittha Lalang, Jeremy Watts, Martin Lepage, Pablo M Rusjan, Romina Mizrahi
Background and Hypothesis Cognitive impairments are particularly disabling for patients with a psychotic disorder and often persist despite optimization of antipsychotic treatment. Thus, motivating an extension of the research focus on the endocannabinoid system. The aim of this study was to evaluate group differences in brain fatty acid amid hydrolase (FAAH), an endocannabinoid enzyme between first-episode
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Effects on Multimodal Connectivity Patterns in Female Schizophrenia During 8 Weeks of Antipsychotic Treatment Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-27 Shuzhan Gao, Yunkai Sun, Fan Wu, Jing Jiang, Ting Peng, Rongrong Zhang, Chenxi Ling, Yanlin Han, Qing Xu, Lulu Zou, Yanhui Liao, Chuang Liang, Daoqiang Zhang, Shile Qi, Jinsong Tang, Xijia Xu
Background and Hypothesis Respective abnormal structural connectivity (SC) and functional connectivity (FC) have been reported in individuals with schizophrenia. However, transmodal associations between SC and FC following antipsychotic treatment, especially in female schizophrenia, remain unclear. We hypothesized that increased SC-FC coupling may be found in female schizophrenia, and could be normalized
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Development and Validation of a Brief Age-Normed Screening Tool for Subthreshold Psychosis Symptoms in Youth Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-21 Monica E Calkins, Arielle Ered, Tyler M Moore, Lauren K White, Jerome Taylor, Alexander B Moxam, Kosha Ruparel, Daniel H Wolf, Theodore D Satterthwaite, Christian G Kohler, Ruben C Gur, Raquel E Gur
Background and Hypothesis Improvements in screening tools for early subthreshold psychosis symptoms are needed to facilitate early identification and intervention efforts, especially given the challenges of rapidly differentiating age-appropriate experiences from potential early signs of emerging psychosis. Tools can be lengthy and time-consuming, impacting their utility and accessibility across clinical
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Characterizing the Clinical Trajectory and Predicting Persistence and Deterioration of Attenuated Psychotic Symptoms in Ultra-High-Risk Individuals Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-21 Cassandra Wannan, Isabelle Scott, Dominic Dwyer, Scott R Clark, Simon Hartmann, Rochelle Ruby Ye, G Paul Amminger, Hok Pan Yuen, Suzie Lavoie, Connie Markulev, Miriam R Schaefer, Jessica A Hartmann, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B Hickie, Gregor Berger, Eric Y H Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Andrew Thompson
Background Almost 40% of individuals at ultra-high risk (UHR) for psychosis experience persistent attenuated psychotic symptoms (APS) yet it is unclear (1) whether they share overlapping clinical and functional outcomes compared to individuals who transition to psychosis, (2) when symptom and functioning trajectories begin to diverge between UHR individuals with different clinical outcomes, and (3)
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Revisiting the Defeatist Performance Belief Scale in Adults With Schizophrenia and Youth at Clinical High-Risk for Psychosis: A Comprehensive Psychometric Analysis Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-14 Lauren Luther, Anthony O Ahmed, Paul M Grant, Eric Granholm, James M Gold, Trevor F Williams, Danielle Pratt, Jason Holden, Elaine F Walker, Lauren Arnold, Lauren M Ellman, Vijay A Mittal, Richard Zinbarg, Steve M Silverstein, Philip R Corlett, Albert R Powers, Scott W Woods, James A Waltz, Jason Schiffman, Gregory P Strauss
Background and Hypothesis In accordance with the Cognitive Model of Negative Symptoms, defeatist performance beliefs (DPBs) are an important psychosocial mechanism of negative symptoms in schizophrenia-spectrum groups. DPBs are also mediators of negative symptom improvement in clinical trials. Despite the clinical significance of DPBs and their inclusion as a mechanism of change measure in clinical
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Childhood Trauma Across the Schizophrenia Spectrum: A Comparison of Schizotypal Personality Disorder and Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-11 Chi C Chan, Elen-Sarrah Dolgopolskaia, Kim E Goldstein, Mary Kowalchyk, Sana Aladin, Katelyn N Challman, Sabrina Ng, Kaitlyn Reynolds, Danielle Russo, Kalpana N Kapil-Pair, Sean Hollander, Timothy Rice, M Mercedes Perez-Rodriguez, M Mehmet Haznedar, Margaret M McClure, Philip R Szeszko, Erin A Hazlett
Background The etiology of schizophrenia involves both biological and environmental risk factors. Studying childhood trauma in disorders along the schizophrenia spectrum, including schizotypal personality disorder (SPD), can inform early risk and protective factors for psychosis. However, no study has directly compared childhood trauma between SPD and schizophrenia. Study Design One hundred twenty-four
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Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-11 Victoria Rodriguez, Luis Alameda, Monica Aas, Charlotte Gayer-Anderson, Giulia Trotta, Edoardo Spinazzola, Diego Quattrone, Giada Tripoli, Hannah E Jongsma, Simona Stilo, Caterina La Cascia, Laura Ferraro, Daniele La Barbera, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Elena Bonora, Stéphane Jamain, Jean-Paul Selten, Eva Velthorst, Lieuwe de Haan, Pierre-Michel Llorca, Manuel Arrojo, Julio Bobes
Background Multiple genetic and environmental risk factors play a role in the development of both schizophrenia-spectrum disorders and affective psychoses. How they act in combination is yet to be clarified. Methods We analyzed 573 first episode psychosis cases and 1005 controls, of European ancestry. Firstly, we tested whether the association of polygenic risk scores for schizophrenia, bipolar disorder
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The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders: A Two-Step Mendelian Randomization Analysis Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-11 Linlin Zhao, Liwen Tan, Weiqing Liu, Sijie Zhang, Aijun Liao, Liu Yuan, Ying He, Xiaogang Chen, Zongchang Li
Background and Hypothesis Inflammatory proteins are implicated in psychiatric disorders, but the causality and underlying mechanisms remain unclear. Study Design We conducted bidirectional Mendelian randomization (MR) using genetic variants from genome-wide association studies (GWAS) for 91 inflammatory proteins (N = 14 824) and 11 psychiatric disorders (N = 9725 to 1 035 760). The primary analysis
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Metformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-10 Aoife Carolan, Caroline Hynes-Ryan, Sri Mahavir Agarwal, Rita Bourke, Walter Cullen, Fiona Gaughran, Margaret K Hahn, Amir Krivoy, John Lally, Stefan Leucht, John Lyne, Robert A McCutcheon, Michael J Norton, Karen O’Connor, Benjamin I Perry, Toby Pillinger, David Shiers, Dan Siskind, Andrew Thompson, Donal O’Shea, Dolores Keating, Brian O’Donoghue
Background Overweight and obesity are highly prevalent in people with severe mental illness (SMI). Antipsychotic-induced weight gain (AIWG) is one of the most commonly reported and distressing side effects of treatment and people living with SMI place a high value on the avoidance of this side effect. Metformin is the most effective pharmacological intervention studied for the prevention of AIWG yet
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Advances in MRI Research for First-Episode Schizophrenia: A Selective Review and NSFC-Funded Analysis Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-10 Qi Yang, Xingchen Pan, Jun Yang, Ying Wang, Tingting Tang, Weisheng Guo, Ning Sun
Background and Hypotheses The causes of schizophrenia remain unclear, and research has been hindered by the lack of quantifiable standards. However, magnetic resonance imaging (MRI) is addressing these challenges, revealing critical neurobiological details and emphasizing its importance in both evaluation and treatment. Study Design First, we reviewed the progress of research on structural MRI (sMRI)
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Examining Psychosis Risk in Sexual Minority Youth: Increased Exposure to and Differential Impact of the Social Envirome in Early Adolescence Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-09 Margaux Sageot, Inez Myin-Germeys, Robin Achterhof, Ruud van Winkel
Background and Hypotheses Sexual minority populations have a higher prevalence of psychotic experiences (PE), possibly due to differential experiences within the social envirome in its positive (eg, social support, parenting) and negative aspects (eg, adverse life events, bullying). This study hypothesized that (1) sexual minority adolescents experience more PE, (2) are more exposed to harmful aspects
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Relationship Between Clozapine-Induced Inflammation and Eosinophilia: A Retrospective Cohort Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-12-03 Yuki Kikuchi, Yuji Otsuka, Fumiaki Ito, Yuji Yada, Hiroaki Tanifuji, Hiroshi Komatsu, Hiroaki Tomita
Background and Hypothesis Eosinophilia has not been highlighted in clozapine-induced adverse inflammatory events, as it is often asymptomatic and self-limiting, while drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome occurs rarely. This study aimed to reveal the temporal relationships between eosinophilia and other inflammatory events during clozapine initiation. Study Design The
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Health, Disability, and Economic Inactivity Following a Diagnosis of a Severe Mental Illness: Cohort Study of Electronic Health Records Linked at the Individual-Level, to Census from England Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-28 L Cybulski, M E Dewey, R Hildersley, C Morgan, R Stewart, M Wuerth, J Das-Munshi
Background The association of social and clinical indicators with employment, disability, and health outcomes among individuals with severe mental illnesses (SMI) remains unclear. Existing evidence primarily comes from smaller cohort studies limited by shorter follow-up and high attrition, or registry-based research, which lacks information on important social determinants. Study Design We utilized
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Evaluation of the Electroconvulsive Therapy’s Impact on Retinal Structures in First-Episode Psychosis Patients Using Optical Coherence Tomography Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-26 Faruk Kurhan, Veysi Yıldız, Gülsüm Zuhal Kamış, Kübra Karataş, Muhammed Batur
Background and Hypothesis Schizophrenia is a complex disorder thought to have neurodevelopmental and neurodegenerative aspects. Optical coherence tomography (OCT) measurements of schizophrenia patients revealed that the retinal layers of these patients were thinner than those of healthy controls. This study aimed to examine retinal changes in first-episode psychosis patients treated with electroconvulsive
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”Short” Versus “Long” Duration of Untreated Psychosis in People with First-Episode Psychosis: A Systematic Review and Meta-Analysis of Baseline Status and Follow-Up Outcomes Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-24 Ana Catalan, Gonzalo Salazar de Pablo, Claudia Aymerich, Daniel Guinart, Javier Goena, Lander Madaria, Malein Pacho, Luis Alameda, Nathalia Garrido-Torres, Borja Pedruzo, Jose M Rubio, Miguel Angel Gonzalez-Torres, Paolo Fusar-Poli, Christoph U Correll
Background and Hypothesis Duration of untreated psychosis (DUP) has been linked to worse mental health outcomes in psychotic disorders. We meta-analytically studied the relationship between “long” vs. “short” DUP and mental health outcomes. Study Design This PRISMA/MOOSE-compliant meta-analysis searched for nonoverlapping individual studies from database inception until November 01, 2023, reporting
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Association Between Peptide Antigen-Related Antibody Levels and the Short- and Long-Term Efficacy of Antipsychotic Treatment in Drug-Naïve First-Episode Schizophrenia Patients Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-22 Yue Zheng, Jian Du, Mingqia Wang, Enpeng Zhou, Qi Zhou, Yunfei Ji, Bingjie Huang, Xiaodong Guo, Tianqi Gao, Wanheng Hu, Xiaolin Yin, Xianghe Wang, Chengcheng Pu, Xin Yu
Objective This study investigated the relationships between baseline peptide antigen-related IgG levels and 8-week antipsychotic drug (APD) treatment response rates and one-year treatment outcomes, as well as the relationships between changes in peptide antigen-related IgG levels and one-year treatment outcomes, in first-episode schizophrenia (FES) patients. Methods Sixteen peptide antigen-related
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A Systematic Review and Meta-Analysis on Contrast Sensitivity in Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-22 Daniel Linares, Aster Joostens, Cristina de la Malla
Background and Hypothesis Understanding perceptual alterations in mental disorders can help uncover neural and computational anomalies. In schizophrenia, perceptual alterations have been reported for many visual features, including a deficit in contrast sensitivity, a key measure of visual function. The evidence supporting this deficit, however, has not been comprehensively synthesized. Study Design
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The Negative Symptom Inventory-Psychosis Risk (NSI-PR): Psychometric Validation of the Final 11-Item Version Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-20 Gregory P Strauss, Elaine F Walker, Nathan T Carter, Lauren Luther, Vijay A Mittal
Background and Hypotheses The lack of psychometrically validated assessment tools designed specifically to assess negative symptoms in individuals at clinical high risk (CHR) for psychosis represents a significant barrier to the early identification and prevention of psychosis. To address this need, the Negative Symptom Inventory-Psychosis Risk (NSI-PR) was developed based on the iterative, data-driven
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Psychotic Experiences and Risk of Suicidal Thoughts and Behaviors: A Systematic Review and Meta-Analysis of Longitudinal Population Studies Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-17 Kirstie O’Hare, Kubra Fadiloglu, Ulla Lång, Colm Healy, Mary Cannon, Jordan DeVylder, Ian Kelleher
Background and Hypothesis Since a prior systematic review and meta-analysis reported an association between psychotic experiences (PEs) and suicidal thoughts and behaviors, a large number of new studies have been published on the topic, including several novel studies on the association between PEs and transition from suicidal ideation to attempt. Study Design Two authors independently searched PubMed
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Mitochondrial Dysfunction and Cognitive Impairment in Schizophrenia: The Role of Inflammation Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-13 Guanyu Wang, Senqi Liu, Xiaoyun Fan, Jinming Li, Qianzi Xue, Kang Liu, Xue Li, Yongfeng Yang, Xiujuan Wang, Meng Song, Minglong Shao, Wenqiang Li, Yong Han, Luxian Lv, Xi Su
Background and Hypothesis The complex immune-brain interactions and the regulatory role of mitochondria in the immune response suggest that mitochondrial damage reported in schizophrenia (SZ) may be related to abnormalities observed in immune and brain functions. Study Design Mitochondrial DNA copy number (mtDNA CN), a biomarker of mitochondrial function, was assessed in peripheral blood leukocytes
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Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-11 Xiaolu Zhang, Jake Valeri, Mahmoud A Eladawi, Barbara Gisabella, Michael R Garrett, Eric J Vallender, Robert McCullumsmith, Harry Pantazopoulos, Sinead M O’Donovan
Background and Hypothesis The amygdala, crucial for mood, anxiety, fear, and reward regulation, shows neuroanatomical and molecular divergence in psychiatric disorders like schizophrenia, bipolar disorder and major depression. This region is also emerging as an important regulator of metabolic and immune pathways. The goal of this study is to address the paucity of molecular studies in the human amygdala
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Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-02 Kristin S Cadenhead, Jean Addington, Carrie E Bearden, Tyrone D Cannon, Barbara A Cornblatt, Matcheri Keshavan, Daniel H Mathalon, Diana O Perkins, William Stone, Elaine F Walker, Scott W Woods
Background and Hypothesis Studying individuals at Clinical High Risk (CHR) for psychosis provides an opportunity to examine protective factors that predict resilient outcomes. Here, we present a model for the study of protective factors in CHR participants at the very highest risk for psychotic conversion based on the Psychosis Risk Calculator. Study Design CHR participants (N = 572) from NAPLS3 were
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The Effects of Cognitive Remediation on Negative Symptoms in Schizophrenia-Spectrum Illness: A Meta-analytic Investigation of Efficacy Schizophr. Bull. (IF 5.3) Pub Date : 2024-11-01 Grace Melville, Clara Preisig, Michael Zheng, Matthew M Kurtz
Background and Hypothesis The number of clinical efficacy trials of Cognitive Remediation (CR), a behavioral intervention consisting of cognitive task practice and/or strategy training to improve cognitive skills in schizophrenia, has increased substantially over the past 25 years. While recent reviews have highlighted the effects of CR on cognition and function, CR effects on negative symptoms remain
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Yoga-Based Group Intervention for Inpatients with Schizophrenia Spectrum Disorders—Feasibility, Acceptability, and Preliminary Outcomes of a Rater-Blinded Randomized Controlled Trial Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-31 Inge Hahne, Marco Zierhut, Niklas Bergmann, Eric Hahn, Thi Minh Tam Ta, Claudia Calvano, Malek Bajbouj, Kerem Böge
Background and Hypothesis The efficacy of yoga as an adjunctive treatment for schizophrenia spectrum disorders (SSD) has garnered interest. While yoga may positively influence various symptom domains, further investigation is needed due to the limited number, quality, and generalizability of studies. This study assessed the feasibility and acceptability (primary outcome) of a yoga-based group intervention
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Molecular Evidence for Altered Angiogenesis in Neuroinflammation-Associated Schizophrenia and Bipolar Disorder Implicate an Abnormal Midbrain Blood-Brain Barrier Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-29 Yunting Zhu, Maree J Webster, Gerardo Mendez Victoriano, Frank A Middleton, Paul T Massa, Cynthia Shannon Weickert
Background and Hypothesis Angiogenesis triggered by inflammation increases BBB permeability and facilitates macrophage transmigration. In the midbrain, we have discovered molecular alterations related to the blood-brain barrier (BBB), including endothelial cell changes associated with macrophage diapedesis, in neuroinflammatory schizophrenia and bipolar disorder, but changes in angiogenesis are yet
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Sex Differences in Subclinical Psychotic Experiences: The Role of Daily-Life Social Interactions Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-21 Zeynep Akcaoglu, Inez Myin-Germeys, Thomas Vaessen, Julie J Janssens, Martien Wampers, Eva Bamps, Ginette Lafit, Olivia J Kirtley, Robin Achterhof
Background and Hypothesis Sex differences in psychosis are reported across the psychosis spectrum, including in subclinical stages. An important factor in understanding these variations is the subjective experience of everyday social interactions (SI). We investigated whether the presence of psychotic experiences (PEs), as well as associated distress, differs between men and women. We focused on the
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Clinician-Reported Negative Symptom Scales: A Systematic Review of Measurement Properties Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-18 Lucia Weigel, Sophia Wehr, Silvana Galderisi, Armida Mucci, John M Davis, Stefan Leucht
Background Negative symptoms of schizophrenia are correlated with reduction of normal function and lower quality of life. They were newly defined by the NIMH-MATRICS Consensus in 2005, dividing the rating tools to assess them into first-generation scales, developed before the Consensus, and second-generation scales, based on the recently introduced definitions. Methods The COnsensus-based Standards
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Bistable Perception Discriminates Between Depressive Patients, Controls, Schizophrenia Patients, and Their Siblings Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-18 Elahe Arani, Simona Garobbio, Maya Roinishvili, Eka Chkonia, Michael H Herzog, Richard J A van Wezel
Background and Hypothesis Individuals with schizophrenia have less priors than controls, meaning they rely less upon their prior experiences to interpret the current stimuli. These differences in priors are expected to show as higher alternation rates in bistable perception tasks like the Structure-from-Motion (SfM) paradigm. In this paradigm, continuously moving dots in two dimensions are perceived
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Probiotic Formulation for Patients With Bipolar or Schizophrenia Spectrum Disorder: A Double-Blind, Randomized Placebo-Controlled Trial Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-14 Jenny Borkent, Magdalini Ioannou, Dorien Neijzen, Bartholomeus C M Haarman, Iris E C Sommer
Background and Hypothesis Probiotic augmentation offers a promising treatment for bipolar disorder (BD) and schizophrenia spectrum disorder (SSD). By targeting microbiome deviations, they may improve both gut and brain health. Study Design In this double-blind, randomized, placebo-controlled trial with the multi-strain probiotic formulation Ecologic BARRIER, we aimed to improve psychiatric and cognitive
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Exploring the Interactions Between Psychotic Symptoms, Cognition, and Environmental Risk Factors: A Bayesian Analysis of Networks Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-14 Minke J Bosma, Maarten Marsman, Jentien M Vermeulen, Karoline B S Huth, Lieuwe de Haan, Behrooz Z Alizadeh, Claudia J P Simons, Frederike Schirmbeck
Background and Hypothesis Psychotic disorders (PDs) have huge personal and societal impact, and efforts to improve outcomes in patients are continuously needed. Environmental risk factors (ERFs), especially modifiable risk factors, are important to study because they pose a target for intervention and prevention. No studies have investigated ERFs, cognition, and psychotic symptoms together in a network
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Retina in Clinical High-Risk and First-Episode Psychosis Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-12 Cemal Demirlek, Berat Arslan, Merve S Eyuboglu, Berna Yalincetin, Ferdane Atas, Ezgi Cesim, Muhammed Demir, Simge Uzman Ozbek, Elif Kizilay, Burcu Verim, Ekin Sut, Burak Baykara, Mahmut Kaya, Berna B Akdede, Emre Bora
Background and Hypothesis Abnormalities in the retina are observed in psychotic disorders, especially in schizophrenia. Study Design Using spectral-domain optical coherence tomography, we investigated structural retinal changes in relatively metabolic risk-free youth with clinical high-risk (CHR, n = 34) and first-episode psychosis (FEP, n = 30) compared with healthy controls (HCs, n = 28). Study Results
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Language, Motor Ability and Related Deficits in Children at Familial Risk of Schizophrenia or Bipolar Disorder Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-11 Marta Schiavon, Birgitte K Burton, Nicoline Hemager, Aja N Greve, Katrine S Spang, Ditte Ellersgaard, Kerstin Jessica Plessen, Jens Richardt M Jepsen, Anne A E Thorup, Thomas Werge, Merete Nordentoft, Ron Nudel
Background It is known that impairments in linguistic ability and motor function tend to co-occur in children, and that children from families with parental mental illness such as schizophrenia tend to perform poorly in both domains, but the exact nature of these links has not yet been fully elucidated. Design In this study, we leveraged the first wave of the Danish High Risk and Resilience Study (VIA
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Defining Urbanicity in the Context of Psychosis Research: A Qualitative Systematic Literature Review Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-11 Franco Mascayano, Jiwon Lee, Xinyu Yang, Zeyu Li, Rodrigo Casanueva, Viviana Hernández, Javiera Burgos, Ana Carolina Florence, Lawrence H Yang, Ezra Susser
Background and Hypothesis Numerous studies have found that being born or raised in urban environments increases the odds of developing psychosis in Northern and Western Europe. However, available research from Southern Europe, Latin America, and Asia has reported null results. A limitation in most studies to date is the inadequate characterization of urban and rural life components that may contribute
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Risk Factors for Late-Onset Psychosis: A Case-Control Study Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-09 Joseph P Skinner, Ann K Shinn, Lauren V Moran
Background and Hypothesis The onset of schizophrenia occurs after the age of 40 in up to 20% of cases. We aim to depict risk factors for first-episode psychosis after the age of 40 by comparing late-onset psychosis (LOP) patients to healthy age-matched controls. Study Design In this case-control study using electronic health records, 142 individuals aged 40–65 years with an encounter for a first episode
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Relapse Following Electroconvulsive Therapy for Schizophrenia: A Systematic Review and Meta-analysis Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-05 Nobuatsu Aoki, Aran Tajika, Taro Suwa, Hirotsugu Kawashima, Kazuyuki Yasuda, Toshiyuki Shimizu, Niina Uchinuma, Hirotaka Tominaga, Xiao Wei Tan, Azriel H K Koh, Phern Chern Tor, Stevan Nikolin, Donel Martin, Masaki Kato, Colleen Loo, Toshihiko Kinoshita, Toshi A Furukawa, Yoshiteru Takekita
Background Evidence regarding schizophrenia relapse following acute electroconvulsive therapy (ECT) is sparse compared with that for depression, and we have no clear consensus on relapse proportions. We aimed to provide longitudinal information on schizophrenia relapse following acute ECT. Study Design This systematic review and meta-analysis included randomised controlled trials (RCTs) and observational
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The Optimal Dosage and Duration of Metformin for Prevention and Treatment of Antipsychotic-Induced Weight Gain: An Updated Systematic Review and Meta-Analysis Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-03 Tzu-Rong Peng, Jou-An Chen, Jen-Ai Lee, Chih-Pin Hsing, Ming-Chia Lee, Shih-Ming Chen
Background Weight gain and metabolic complications are substantial adverse effects associated with second-generation antipsychotics. However, comprehensive guidelines for managing antipsychotic-induced weight gain are lacking. Methods This review included all double-blind, placebo-controlled studies investigating metformin’s effectiveness in addressing antipsychotic-related weight gain. We systematically
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Emotion Processing and Its Relationship to Social Functioning and Symptoms in Psychotic Disorder: A Systematic Review and Meta-analysis Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-03 Sean Murrihy, Kate Filia, Sue Cotton, Lisa Phillips, Sarah Youn, Anuradhi Jayasinghe, Anna Wrobel, Eslam M Bastawy, Kelly Allott, Amity Watson
Background Emotion processing (EP) is impaired in individuals with psychosis and associated with social functioning; however, it is unclear how symptoms fit into this relationship. The aim of this systematic review and meta-analysis was to examine interrelationships between EP, symptoms, and social functioning, test whether different symptom domains mediate the relationship between EP and social functioning
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N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-10-01 Jinghui Tong, Kebing Yang, Wei Li, Leilei Wang, Yi Yin, Yanfang Zhou, Junchao Huang, Ping Zhang, Yanli Zhao, Song Chen, Hongzhen Fan, Yimin Cui, Xingguang Luo, Shuping Tan, Zhiren Wang, Wei Feng, Baopeng Tian, Chiang-Shan R Li, L Elliot Hong, Yunlong Tan
Background and Hypothesis Sensory gating deficit is considered a pathophysiological feature of schizophrenia, which has been linked to N-methyl-d-aspartate receptor (NMDAR) hypofunction as one of the potential underlying mechanisms. Here, we hypothesize that higher levels of NMDAR antibody (Ab) may contribute to the sensory gating deficits in schizophrenia. Study Design We enrolled 72 non-smoking inpatients
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Efficacy of User Self-Led and Human-Supported Digital Health Interventions for People With Schizophrenia: A Systematic Review and Meta-Analysis Schizophr. Bull. (IF 5.3) Pub Date : 2024-09-28 Urska Arnautovska, Mike Trott, Kathryn Jemimah Vitangcol, Alyssa Milton, Ellie Brown, Nicola Warren, Stefan Leucht, Joseph Firth, Dan Siskind
Background Digital health interventions (DHIs) may enable low cost, scalable improvements in the quality of care for adults with schizophrenia. Given the fast-growing number of studies using these tools, this review aimed to assess the efficacy and feasibility of randomized controlled trials (RCTs) of DHIs among people with schizophrenia, focusing on human support. Design A systematic search of PubMed
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Anhedonia Across and Beyond the Schizophrenia Spectrum Schizophr. Bull. (IF 5.3) Pub Date : 2024-09-26 Raymond C K Chan, Ling-ling Wang, Jia Huang, Yi Wang, Simon S Y Lui
Anhedonia refers to the diminished ability to experience pleasure, and is a core feature of schizophrenia (SCZ). The neurocognitive and neural correlates of anhedonia remain elusive. Based on several influential theoretical models for negative symptoms, this selective review proposed four important neurocognitive domains, which may unveil the neurobiological mechanisms of anhedonia. The authors critically
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The Common Structure of the Major Psychoses: More Similarities Than Differences in the Network Structures of Schizophrenia, Schizoaffective Disorder, and Psychotic Bipolar Disorder Schizophr. Bull. (IF 5.3) Pub Date : 2024-09-11 Wen Shao, Melanie Simmonds-Buckley, Orestis Zavlis, Richard P Bentall
Background and Hypothesis There has been a century-long debate about whether the major psychoses (eg, bipolar disorder, schizophrenia, and schizoaffective disorder) are one disorder with various manifestations or different disease entities. Traditional approaches using dimensional models have not provided decisive findings. Here, we address this question by examining the network constellation of affective
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Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Reduces Variability in Brain Function in Schizophrenia: Data From a Double-Blind, Randomized, Sham-Controlled Trial Schizophr. Bull. (IF 5.3) Pub Date : 2024-09-10 Christin Schifani, Colin Hawco, Zafiris J Daskalakis, Tarek K Rajji, Benoit H Mulsant, Vinh Tan, Erin W Dickie, Iska Moxon-Emre, Daniel M Blumberger, Aristotle N Voineskos
Background/Hypothesis There is increasing awareness of interindividual variability in brain function, with potentially major implications for repetitive transcranial magnetic stimulation (rTMS) efficacy. We perform a secondary analysis using data from a double-blind randomized controlled 4-week trial of 20 Hz active versus sham rTMS to dorsolateral prefrontal cortex (DLPFC) during a working memory
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Modeling the Determinants of Subjective Well-Being in Schizophrenia Schizophr. Bull. (IF 5.3) Pub Date : 2024-09-10 Jae Hoon Jeong, Jayoun Kim, Nuree Kang, Yong Min Ahn, Yong Sik Kim, Donghwan Lee, Se Hyun Kim
BackgroundThe ultimate goal of successful schizophrenia treatment is not just to alleviate psychotic symptoms, but also to reduce distress and achieve subjective well-being (SWB). We aimed to identify the determinants of SWB and their interrelationships in schizophrenia.MethodsData were obtained from 637 patients with schizophrenia enrolled in multicenter, open-label, non-comparative clinical trials
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EEG-based Signatures of Schizophrenia, Depression, and Aberrant Aging: A Supervised Machine Learning Investigation Schizophr. Bull. (IF 5.3) Pub Date : 2024-09-09 Elif Sarisik, David Popovic, Daniel Keeser, Adyasha Khuntia, Kolja Schiltz, Peter Falkai, Oliver Pogarell, Nikolaos Koutsouleris
Background Electroencephalography (EEG) is a noninvasive, cost-effective, and robust tool, which directly measures in vivo neuronal mass activity with high temporal resolution. Combined with state-of-the-art machine learning (ML) techniques, EEG recordings could potentially yield in silico biomarkers of severe mental disorders. Hypothesis Pathological and physiological aging processes influence the
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Modeling Decision-Making in Schizophrenia: Associations Between Computationally Derived Risk Propensity and Self-Reported Risk Perception Schizophr. Bull. (IF 5.3) Pub Date : 2024-09-07 Emma N Herms, Joshua W Brown, Krista M Wisner, William P Hetrick, David H Zald, John R Purcell
Background and Hypothesis Schizophrenia is associated with a decreased pursuit of risky rewards during uncertain-risk decision-making. However, putative mechanisms subserving this disadvantageous risky reward pursuit, such as contributions of cognition and relevant traits, remain poorly understood. Study Design Participants (30 schizophrenia/schizoaffective disorder [SZ]; 30 comparison participants
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Psychosis Risk: Time to Look Empirically at a First-step Economical-pragmatic Way to Examine Anomalous Self-experience. Exploring the SQuEASE-11 Schizophr. Bull. (IF 5.3) Pub Date : 2024-09-07 Paul Møller, Barnaby Nelson, Patrick D McGorry, Cristina Mei, G Paul Amminger, Hok Pan Yuen, Melissa Kerr, Jessica Spark, Nicky Wallis, Andrea Polari, Shelley Baird, Kate Buccilli, Sarah-Jane A Dempsey, Natalie Ferguson, Melanie Formica, Marija Krcmar, Amelia L Quinn, Yohannes Mebrahtu, Arlan Ruslins, Rebekah Street, Lisa Dixon, Cameron Carter, Rachel Loewy, Tara A Niendam, Martha Shumway, Cassandra
Background Since the late 1990s, there has been a worldwide surge of scientific interest in the pre-psychotic phase, resulting in the introduction of several clinical tools for early detection. The predictive accuracy of these tools has been limited, motivating the need for methodological and perspectival improvements. The EASE manual supports systematic assessment of anomalous self-experience, and
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Anti-LGI1 Antibody-Associated Encephalitis Misdiagnosed as Schizophrenia: A Case Report Schizophr. Bull. (IF 5.3) Pub Date : 2024-08-31 Jin-he Zhang, Bing-bing Fu, Wei Wang, Cong-cong Sun, Jin-jie Xu
Anti-leucine-rich glioma-inactivated 1 (LGI1) antibody-associated encephalitis is a rare but clinically significant form of autoimmune encephalitis, predominantly affecting middle-aged men. Its heterogeneous clinical presentation often leads to misdiagnosis, commonly as other neurological or psychiatric disorders. This report details the case of a 46-year-old male who initially presented with depressive
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Static and Dynamic Dysconnectivity in Early Psychosis: Relationship With Symptom Dimensions Schizophr. Bull. (IF 5.3) Pub Date : 2024-08-30 Giulia Cattarinussi, David Antonio Grimaldi, Mohammad Hadi Aarabi, Fabio Sambataro
Background and Hypothesis Altered functional connectivity (FC) has been frequently reported in psychosis. Studying FC and its time-varying patterns in early-stage psychosis allows the investigation of the neural mechanisms of this disorder without the confounding effects of drug treatment or illness-related factors. Study Design We employed resting-state functional magnetic resonance imaging (rs-fMRI)
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Neurostructural, Neurofunctional, and Clinical Features of Chronic, Untreated Schizophrenia: A Narrative Review Schizophr. Bull. (IF 5.3) Pub Date : 2024-08-30 Biqiu Tang, Li Yao, Jeffrey R Strawn, Wenjing Zhang, Su Lui
Studies of individuals with chronic, untreated schizophrenia (CUS) can provide important insights into the natural course of schizophrenia and how antipsychotic pharmacotherapy affects neurobiological aspects of illness course and progression. We systematically review 17 studies on the neuroimaging, cognitive, and epidemiological aspects of CUS individuals. These studies were conducted at the Shanghai