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Reproductive outcomes after letrozole stimulated versus artificial frozen-thawed embryo transfer cycles in women with PCOS and/or oligo-anovulation: a systematic review and meta-analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2025-05-27 Nathalie Søderhamn Bülow, Marie Louise Wissing, Nick Macklon, Anja Pinborg, Kristine Løssl
BACKGROUND The global increase in frozen-thawed embryo transfer (FET) cycles has led to a critical evaluation of endometrial preparation methods. While various approaches such as natural or modified natural cycle FET, stimulated FET by use of letrozole (LTZ) and/or gonadotrophins, and artificial cycle (AC) FET, are currently in clinical use, the optimal regimen remains unclear, particularly for women
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Spermatogonia: a unique stem cell orchestrating species-specific transition from pluripotency to sperm production. Hum. Reprod. Update (IF 14.8) Pub Date : 2025-05-23 Fabian Schlag,Camille Dion,Lessly P Sepulveda-Rincon,Stefan Schlatt,Swati Sharma
BACKGROUND Male germline stem cells are relevant for stem cell researchers but also for andrologists as they are crucial for testis function and initiation/maintenance of spermatogenesis. They are also considered a target for fertility preservation in the male; e.g. germ cell transplantation or testicular grafting rely on spermatogonial stem cells (SSCs) and may soon become clinical tools to recover
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Modeling the extension of ovarian function after therapeutic targeting of the primordial follicle reserve Hum. Reprod. Update (IF 14.8) Pub Date : 2025-05-05 Joshua Johnson, John W Emerson, Annika Smith, Kayla Medina, Evelyn E Telfer, Richard A Anderson, Sean D Lawley
BACKGROUND Women are increasingly choosing to delay childbirth, and those with low ovarian reserves indicative of primary ovarian insufficiency are at risk for sub- and infertility and also the early onset of menopause. Experimental strategies that promise to extend the duration of ovarian function in women are currently being developed. One strategy is to slow the rate of loss of existing primordial
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Moving toward totipotency: the molecular and cellular features of totipotent and naive pluripotent stem cells Hum. Reprod. Update (IF 14.8) Pub Date : 2025-04-29 Lingyue Hua, Yuyang Peng, Liying Yan, Peng Yuan, Jie Qiao
BACKGROUND Dissecting the key molecular mechanism of embryonic development provides novel insights into embryogenesis and potential intervention strategies for clinical practices. However, the ability to study the molecular mechanisms of early embryo development in humans, such as zygotic genome activation and lineage segregation, is meaningfully constrained by methodological limitations and ethical
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RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications Hum. Reprod. Update (IF 14.8) Pub Date : 2025-03-31 Yu Xiang, Hsun-Ming Chang, Peter C K Leung, Long Bai, Yimin Zhu
BACKGROUND RNA modifications, collectively known as the epitranscriptome, represent the third layer of gene regulation, influencing gene expression at transcriptional, post-transcriptional, and translational levels. RNA-modifying proteins (RMPs), including writers, erasers, and readers, are responsible for depositing, removing, and recognizing chemical modifications on RNA molecules. These modifications
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Ethical considerations for advancing research using organoid models derived from the placenta. Hum. Reprod. Update (IF 14.8) Pub Date : 2025-03-17 Olivier J M Schäffers,Joost Gribnau,Bas B van Rijn,Eline M Bunnik
BACKGROUND The advent of organoid culture systems has revolutionized our ability to model and study complex tissues in vitro. The placenta is one of the last human organs to have a functional organoid model developed: trophoblast organoids. These 3-dimensional structures, derived from placental tissue, offer researchers a valuable tool for studying previously inaccessible processes that occur within
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Genetic and reproductive strategies to prevent mitochondrial diseases Hum. Reprod. Update (IF 14.8) Pub Date : 2025-03-14 Noemi Castelluccio, Katharina Spath, Danyang Li, Irenaeus F M De Coo, Lyndsey Butterworth, Dagan Wells, Heidi Mertes, Joanna Poulton, Björn Heindryckx
Mitochondrial DNA (mtDNA) diseases pose unique challenges for genetic counselling and require tailored approaches to address recurrence risks and reproductive options. The intricate dynamics of mtDNA segregation and heteroplasmy shift significantly impact the chances of having affected children. In addition to natural pregnancy, oocyte donation, and adoption, IVF-based approaches can reduce the risk
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Molecular insights into sperm head shaping and its role in human male fertility Hum. Reprod. Update (IF 14.8) Pub Date : 2025-03-05 Jiaxin He, Xinle Lin, Chen Tan, Yong Li, Lilan Su, Ge Lin, Yue-Qiu Tan, Chaofeng Tu
BACKGROUND Sperm head shaping, controlled by the acrosome-acroplaxome-manchette complex, represents a significant morphological change during spermiogenesis and involves numerous proteins expressed in a spatially and temporally specific manner. Defects in sperm head shaping frequently lead to teratozoospermia concomitant with oligozoospermia and asthenozoospermia, but the pathogenic mechanism underlying
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Harnessing omics data for drug discovery and development in ovarian aging Hum. Reprod. Update (IF 14.8) Pub Date : 2025-02-20 Fengyu Zhang, Ming Zhu, Yi Chen, Guiquan Wang, Haiyan Yang, Xinmei Lu, Yan Li, Hsun-Ming Chang, Yang Wu, Yunlong Ma, Shuai Yuan, Wencheng Zhu, Xi Dong, Yue Zhao, Yang Yu, Jia Wang, Liangshan Mu
BACKGROUND Ovarian aging occurs earlier than the aging of many other organs and has a lasting impact on women’s overall health and well-being. However, effective interventions to slow ovarian aging remain limited, primarily due to an incomplete understanding of the underlying molecular mechanisms and drug targets. Recent advances in omics data resources, combined with innovative computational tools
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Parental conditions, modifiable lifestyle factors, and first trimester growth and development: a systematic review. Hum. Reprod. Update (IF 14.8) Pub Date : 2025-05-01 Naomi Graafland,Melek Rousian,Merle L de Zwart,Regine P M Steegers-Theunissen,Eric A P Steegers,Anke G Posthumus
INTRODUCTION The embryonic period in human development is the foundation of lifelong and even transgenerational health. Although previously believed to be uniform, there is increasing evidence that embryonic growth is influenced by the conditions and modifiable lifestyle factors of parents in the periconception period. In ongoing pregnancies, a delay in growth in the first trimester has been associated
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Defects in mRNA splicing and implications for infertility: a comprehensive review and in silico analysis. Hum. Reprod. Update (IF 14.8) Pub Date : 2025-05-01 Kuokuo Li,Yuge Chen,Yuying Sheng,Dongdong Tang,Yunxia Cao,Xiaojin He
BACKGROUND mRNA splicing is a fundamental process in the reproductive system, playing a pivotal role in reproductive development and endocrine function, and ensuring the proper execution of meiosis, mitosis, and gamete function. Trans-acting factors and cis-acting elements are key players in mRNA splicing whose dysfunction can potentially lead to male and female infertility. Although hundreds of trans-acting
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Fertility in transgender and gender diverse people: systematic review of the effects of gender-affirming hormones on reproductive organs and fertility Hum. Reprod. Update (IF 14.8) Pub Date : 2025-01-24 C De Roo, F Schneider, T H R Stolk, W L J van Vugt, D Stoop, N M van Mello
BACKGROUND Transgender and gender diverse (TGD) people seek gender-affirming care at any age to manage gender identities or expressions that differ from their birth gender. Gender-affirming hormone treatment (GAHT) and gender-affirming surgery may alter reproductive function and/or anatomy, limiting future reproductive options to varying degrees, if individuals desire to either give birth or become
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Celebrating 30 years at Human Reproduction Update. Hum. Reprod. Update (IF 14.8) Pub Date : 2025-01-01 Arne S Sunde,Madelon van Wely
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Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2024-12-21 Nienke Schouten, Rui Wang, Helen Torrance, Theodora Van Tilborg, Ercan Bastu, Christina Bergh, Thomas D’Hooghe, Jesper Friis Petersen, Kannamannadiar Jayaprakasan, Yacoub Khalaf, Ellen Klinkert, Antonio La Marca, Lan Vuong, Louise Lapensée, Sarah Lensen, Åsa Magnusson, Adolfo Allegra, Anders Nyboe Andersen, Simone Oudshoorn, Biljana Popovic-Todorovic, Ben Willem Mol, Marinus Eijkemans, Frank Broekmans
BACKGROUND The ovarian response to gonadotropin stimulation varies widely among women, and could impact the probability of live birth as well as treatment risks. Many studies have evaluated the impact of different gonadotropin starting doses, mainly based on predictive variables like ovarian reserve tests (ORT) including anti-Müllerian hormone (AMH), antral follicle count (AFC), and basal follicle-stimulating
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The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation Hum. Reprod. Update (IF 14.8) Pub Date : 2024-12-14 Nushin Naderi, Marziyeh Tavalaee, Mohammad Hossein Nasr-Esfahani
BACKGROUND Varicocele is an abnormal dilation and torsion of the pampiniform venous plexus in the scrotum due to venous reflux, primarily affecting the left side. It affects 15% of men and is a prevalent contributor to male infertility. Varicocele is a complex disorder influenced by genetic, epigenetic, and environmental factors. Epigenetic modifications, which regulate genome activity independently
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The modeling of human implantation and early placentation: achievements and perspectives Hum. Reprod. Update (IF 14.8) Pub Date : 2024-12-14 Tanya Dimova, Marina Alexandrova, Ivaylo Vangelov, Yuan You, Gil Mor
BACKGROUND Successful implantation is a critical step for embryo survival. The major losses in natural and assisted human reproduction appeared to occur during the peri-implantation period. Because of ethical constraints, the fascinating maternal–fetal crosstalk during human implantation is difficult to study and thus, the possibility for clinical intervention is still limited. OBJECTIVE AND RATIONALE
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A systematic review and meta-analysis of double trophectoderm biopsy and/or cryopreservation in PGT: balancing the need for a diagnosis against the risk of harm Hum. Reprod. Update (IF 14.8) Pub Date : 2024-11-13 Letizia Li Piani, Pasquale Petrone, Mariafrancesca Brutto, Anick De Vos, Annelore Van Der Kelen, Alberto Vaiarelli, Laura Rienzi, Alessandro Conforti, Danilo Cimadomo, Willem Verpoest
BACKGROUND To prevent the transfer of embryos affected by monogenic conditions and/or chromosomal defects, preimplantation genetic testing (PGT) requires trophectoderm biopsy and cryopreservation. In 2–6% of biopsies, the diagnosis may be inconclusive due to DNA amplification failure or low-quality results. In these cases, a round of re-warming, re-biopsy, and re-cryopreservation is required to obtain
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Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association Hum. Reprod. Update (IF 14.8) Pub Date : 2024-10-08 Johannes Ott, Geoffroy Robin, Marlene Hager, Didier Dewailly
BACKGROUND Functional hypothalamic amenorrhoea (FHA) is responsible for 20–35% of all cases of secondary amenorrhoea and, thus, is the second most common cause of secondary amenorrhoea after polycystic ovary syndrome (PCOS). A high number of patients with FHA reveal polycystic ovarian morphology (PCOM) on ultrasound. The combination of amenorrhoea and PCOM can lead to confusion. First, amenorrhoeic
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Infertility treatment and offspring blood pressure—a systematic review and meta-analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2024-10-08 Edwina H Yeung, Ian R Trees, Priscilla K Clayton, Kristen J Polinski, Alicia A Livinski, Diane L Putnick
BACKGROUND Studies have inconsistently observed that children conceived by IVF or ICSI have higher blood pressure compared to children not conceived by these ARTs. OBJECTIVE AND RATIONALE The aim was to perform a systematic review and meta-analysis of blood pressure measures of offspring conceived by ART and those conceived naturally. Resolving the suspicion of ART as a risk factor of higher blood
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New insights into the ovulatory process in the human ovary Hum. Reprod. Update (IF 14.8) Pub Date : 2024-09-27 Misung Jo, Mats Brännström, James W Akins, Thomas E Curry
BACKGROUND Successful ovulation is essential for natural conception and fertility. Defects in the ovulatory process are associated with various conditions of infertility or subfertility in women. However, our understanding of the intra-ovarian biochemical mechanisms underlying this process in women has lagged compared to our understanding of animal models. This has been largely due to the limited availability
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Evaluating the diagnostic accuracy of androgen measurement in polycystic ovary syndrome: a systematic review and diagnostic meta-analysis to inform evidence-based guidelines Hum. Reprod. Update (IF 14.8) Pub Date : 2024-09-21 Asmamaw Demis Bizuneh, Anju E Joham, Helena Teede, Aya Mousa, Arul Earnest, James M Hawley, Laura Smith, Ricardo Azziz, Wiebke Arlt, Chau Thien Tay
BACKGROUND Biochemical hyperandrogenism is a hallmark and diagnostic feature of polycystic ovary syndrome (PCOS). However, the most accurate androgen measurement for assessing biochemical hyperandrogenism in PCOS diagnosis remains uncertain. OBJECTIVE AND RATIONALE This systematic review aimed to assess different androgen measures [including total testosterone (TT), calculated free testosterone (cFT)
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Ramadan during pregnancy and offspring health outcomes over the life course: a systematic review and meta-analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2024-08-24 Fabienne Pradella, Paul Witte, Reyn van Ewijk
BACKGROUND Intermittent fasting, such as during Ramadan, is prevalent among pregnant women. However, the association between Ramadan during pregnancy and offspring health along the life course has not been fully established. OBJECTIVE AND RATIONALE Fetal programming research indicates that prenatal exposures, particularly during early pregnancy, can cause long-term structural and physiological changes
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Impact of Bisphenol A and its alternatives on oocyte health: a scoping review Hum. Reprod. Update (IF 14.8) Pub Date : 2024-07-25 Alexandra E Peters, Emmalee A Ford, Shaun D Roman, Elizabeth G Bromfield, Brett Nixon, Kirsty G Pringle, Jessie M Sutherland
BACKGROUND Bisphenol A (BPA) is an endocrine disrupting chemical released from plastic materials, including food packaging and dental sealants, persisting in the environment and ubiquitously contaminating ecosystems and human populations. BPA can elicit an array of damaging health effects and, alarmingly, ‘BPA-free’ alternatives mirror these harmful effects. Bisphenol exposure can negatively impact
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Untangling the independent effect of endometriosis, adenomyosis, and ART-related factors on maternal, placental, fetal, and neonatal adverse outcomes: results from a systematic review and meta-analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2024-07-25 Andrea Busnelli, Nicoletta Di Simone, Edgardo Somigliana, Dalia Greppi, Federico Cirillo, Alessandro Bulfoni, Annalisa Inversetti, Paolo Emanuele Levi-Setti
BACKGROUND Women with endometriosis may constitute a group at a particularly increased risk of pregnancy-related complications. Furthermore, women selected for assisted reproductive technology (ART) are exposed to additional endocrinological and embryological factors that have been associated with adverse pregnancy outcomes. OBJECTIVE AND RATIONALE This study aimed to investigate the independent effect
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The role of fibrosis in endometriosis: a systematic review Hum. Reprod. Update (IF 14.8) Pub Date : 2024-07-08 Guus Vissers, Maddalena Giacomozzi, Wouter Verdurmen, Ron Peek, Annemiek Nap
BACKGROUND Fibrosis is an important pathological feature of endometriotic lesions of all subtypes. Fibrosis is present in and around endometriotic lesions, and a central role in its development is played by myofibroblasts, which are cells derived mainly after epithelial-to-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transdifferentiation (FMT). Transforming growth factor-β (TGF-β) has
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Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage Hum. Reprod. Update (IF 14.8) Pub Date : 2024-06-29 Yican Guo, Liru Xue, Weicheng Tang, Jiaqiang Xiong, Dan Chen, Yun Dai, Chuqing Wu, Simin Wei, Jun Dai, Meng Wu, Shixuan Wang
BACKGROUNDChemotherapy-associated ovarian damage (CAOD) is one of the most feared short- and long-term side effects of anticancer treatment in premenopausal women. Accumulating detailed data show that different chemotherapy regimens can lead to disturbance of ovarian hormone levels, reduced or lost fertility, and an increased risk of early menopause. Previous studies have often focused on the direct
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Correction to: Planned oocyte cryopreservation: a systematic review and meta-regression analysis. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-10-01
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Cellular mechanisms of monozygotic twinning: clues from assisted reproduction Hum. Reprod. Update (IF 14.8) Pub Date : 2024-06-26 Hongbin Jin, Yang Han, Jennifer Zenker
BACKGROUND Monozygotic (MZ) twins are believed to arise from the fission of a single fertilized embryo at different stages. Monochorionic MZ twins, who share one chorion, originate from the splitting of the inner cell mass (ICM) within a single blastocyst. In the classic model for dichorionic MZ twins, the embryo splits before compaction, developing into two blastocysts. However, there are a growing
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Reply. How much evidence is needed to stop calling endometrial scratching 'controversial'? Hum. Reprod. Update (IF 14.8) Pub Date : 2024-12-01 Nienke Van Hoogenhuijze,Frank Broekmans
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Does the holy grail of the evidence pyramid vindicate the controversial practice of endometrial scratching or is there room for healthy skepticism? Hum. Reprod. Update (IF 14.8) Pub Date : 2024-12-01 Baris Ata,Erkan Kalafat
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The role of endometrial scratching in IVF/ICSI: a critical appraisal of individual participant data meta-analysis. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-12-01 Fatih Aktoz
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Reply. The role of endometrial scratching in IVF/ICSI: a critical appraisal of individual participant data meta-analysis. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-12-01 Nienke van Hoogenhuijze,Frank Broekmans
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What is the expected live birth rate per thawed oocyte? Hum. Reprod. Update (IF 14.8) Pub Date : 2024-10-01 Raoul Orvieto
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Reply: What is the expected live birth rate per thawed oocyte? Hum. Reprod. Update (IF 14.8) Pub Date : 2024-10-01 Avi Tsafrir,Ayala Hirsch
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Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations Hum. Reprod. Update (IF 14.8) Pub Date : 2024-05-28 Antonio Capalbo, Guido de Wert, Heidi Mertes, Liraz Klausner, Edith Coonen, Francesca Spinella, Hilde Van de Velde, Stephane Viville, Karen Sermon, Nathalie Vermeulen, Todd Lencz, Shai Carmi
BACKGROUND The genetic composition of embryos generated by in vitro fertilization (IVF) can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited to detecting single-gene, high-risk pathogenic variants, large structural variants, and aneuploidy. Recent advances have made genome-wide genotyping of IVF embryos feasible and affordable, raising the possibility of screening
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Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review Hum. Reprod. Update (IF 14.8) Pub Date : 2024-05-26 Adolfo Rodríguez-Eguren, Clara Bueno-Fernandez, María Gómez-Álvarez, Emilio Francés-Herrero, Antonio Pellicer, José Bellver, Emre Seli, Irene Cervelló
BACKGROUND The establishment and maintenance of pregnancy depend on endometrial competence. Asherman syndrome (AS) and intrauterine adhesions (IUA), or endometrial atrophy (EA) and thin endometrium (TE), can either originate autonomously or arise as a result from conditions (i.e. endometritis or congenital hypoplasia), or medical interventions (e.g. surgeries, hormonal therapies, uterine curettage
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Barriers and enablers to a healthy lifestyle in people with infertility: a mixed-methods systematic review Hum. Reprod. Update (IF 14.8) Pub Date : 2024-05-14 Sophia Torkel, Rui Wang, Robert J Norman, Lijun Zhao, Kai Liu, Dana Boden, Wentong Xu, Lisa Moran, Stephanie Cowan
BACKGROUNDWhile there is a recognized role of optimizing lifestyle (diet and physical activity) behaviours in the management of infertility, the best practice remains unknown and factors influencing the lifestyle of people with infertility are not well understood.OBJECTIVE AND RATIONALEThis systematic review evaluated barriers and enablers to a healthy lifestyle in people with infertility, from the
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Planned oocyte cryopreservation: a systematic review and meta-regression analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2024-04-24 Ayala Hirsch, Bruria Hirsh Raccah, Reut Rotem, Jordana H Hyman, Ido Ben-Ami, Avi Tsafrir
BACKGROUND Awareness of the age-related decline in fertility potential has increased the popularity of planned oocyte cryopreservation (POC). However, data regarding outcomes of POC, including rates of women returning to thaw oocytes, as well as pregnancy and live birth rates, are scarce and based mostly on small case series. OBJECTIVE AND RATIONALE POC was defined as cryopreservation exclusively for
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Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and network meta-analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2024-04-17 David Ruiz-González, Iván Cavero-Redondo, Alba Hernández-Martínez, Andrés Baena-Raya, Sonia Martínez-Forte, Signe Altmäe, Ana M Fernández-Alonso, Alberto Soriano-Maldonado
BACKGROUNDThe increasing prevalence of obesity worldwide poses a significant threat to reproductive function owing, in part, to hormonal disturbances caused by negative feedback between excess adiposity and the hypothalamic–pituitary–ovarian axis. Consequently, finding the most appropriate strategies to lose weight and improve ovulation in women with overweight or obesity is a clinically relevant matter
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Parents’ disclosure to their donor-conceived children in the last 10 years and factors affecting disclosure: a narrative review Hum. Reprod. Update (IF 14.8) Pub Date : 2024-04-09 Michelle A Duff, Sonja Goedeke
BACKGROUNDDisclosure of donor conception has been advocated in several jurisdictions in recent years, especially in those that practice identity-release donation. However, research on disclosure decisions has not been consolidated systematically in the last 10 years to review if parents are telling and what factors may be impacting their decisions.OBJECTIVE AND RATIONALEAre parents disclosing to their
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TGFβ signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-23 Monika Horvat Mercnik, Carolin Schliefsteiner, Gonzalo Sanchez-Duffhues, Christian Wadsack
BACKGROUND The placenta is a unique and pivotal organ in reproduction, controlling crucial growth and cell differentiation processes that ensure a successful pregnancy. Placental development is a tightly regulated and dynamic process, in which the transforming growth factor beta (TGFβ) superfamily plays a central role. This family of pleiotropic growth factors is heavily involved in regulating various
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Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-13 Emilie Derisoud, Hong Jiang, Allan Zhao, Pascale Chavatte-Palmer, Qiaolin Deng
BACKGROUND With increasing significance of developmental programming effects associated with placental dysfunction, more investigations are devoted to improving the characterization and understanding of placental signatures in health and disease. The placenta is a transitory but dynamic organ adapting to the shifting demands of fetal development and available resources of the maternal supply throughout
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Navigating fertility dilemmas across the lifespan in girls with Turner syndrome—a scoping review Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-07 Sanne van der Coelen, Janielle van der Velden, Sapthami Nadesapillai, Didi Braat, Ronald Peek, Kathrin Fleischer
BACKGROUND Girls with Turner syndrome (TS) lack a partial or complete sex chromosome, which causes an accelerated decline of their ovarian reserve. Girls have to deal with several dilemmas related to their fertility, while only a limited number of them are referred to a fertility specialist and counselled about options of family planning on time. OBJECTIVE AND RATIONALE This scoping review provides
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Reply: Endometrial scratching: the light at the end of the tunnel. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-01 N E van Hoogenhuijze,F J M Broekmans
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Endometrial scratching: the light at the end of the tunnel. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-01 Amerigo Vitagliano,Ettore Cicinelli,Antonio Simone Laganà,Alessandro Favilli,Salvatore Giovanni Vitale,Marco Noventa,Gianluca Raffaello Damiani,Miriam Dellino,Pierpaolo Nicolì,Antonio D'Amato,Stefano Bettocchi,Maria Matteo,Stefano Palomba
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Declining global fertility rates and the implications for family planning and family building: an IFFS consensus document based on a narrative review of the literature. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-01 Bart C J M Fauser,G David Adamson,Jacky Boivin,Georgina M Chambers,Christian de Geyter,Silke Dyer,Marcia C Inhorn,Lone Schmidt,Gamal I Serour,Basil Tarlatzis,Fernando Zegers-Hochschild,
BACKGROUND Family-planning policies have focused on contraceptive approaches to avoid unintended pregnancies, postpone, or terminate pregnancies and mitigate population growth. These policies have contributed to significantly slowing world population growth. Presently, half the countries worldwide exhibit a fertility rate below replacement level. Not including the effects of migration, many countries
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The complicated ART of finding consensus on family-building health policy: a comment on the IFFS consensus document. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-01 Alexander Weinreb,Artur Ludwin,Hagai Levine
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A comprehensive review of the new FIGO classification of ovulatory disorders Hum. Reprod. Update (IF 14.8) Pub Date : 2024-02-27 Adam H Balen, Jennifer Tamblyn, Karolina Skorupskaite, Malcolm G Munro
BACKGROUND The World Health Organization (WHO) system for the classification of disorders of ovulation was produced 50 years ago and, by international consensus, has been updated by the International Federation of Gynecology and Obstetrics (FIGO). OBJECTIVE AND RATIONALE This review outlines in detail each component of the FIGO HyPO-P (hypothalamic, pituitary, ovarian, PCOS) classification with a concise
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A systematic review of the association between modifiable lifestyle factors and circulating anti-Müllerian hormone Hum. Reprod. Update (IF 14.8) Pub Date : 2024-02-25 Lotte Werner, Yvonne T van der Schouw, Annelien C de Kat
BACKGROUND Levels of anti-Müllerian hormone (AMH) are known to be associated with lifestyle determinants such as smoking and oral contraception (OC) use. When measuring AMH in clinical practice, it is essential to know which factors may influence circulating levels or ovarian reserve in general. OBJECTIVE AND RATIONALE To date, there is no systematic review or summarizing consensus of the nature and
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Maternal and perinatal outcomes in twin pregnancies following assisted reproduction: a systematic review and meta-analysis involving 802 462 pregnancies Hum. Reprod. Update (IF 14.8) Pub Date : 2024-02-12 Shemoon Marleen, Wasana Kodithuwakku, Ruvini Nandasena, Shezoon Mohideen, John Allotey, Silvia Fernández-García, Andrea Gaetano-Gil, Gabriel Ruiz-Calvo, Joseph Aquilina, Asma Khalil, Priya Bhide, Javier Zamora, Shakila Thangaratinam
BACKGROUND ART is associated with higher rates of twin pregnancies than singleton pregnancies. Whether twin pregnancies conceived following ART have additional maternal and neonatal complications compared with non-ART twin pregnancies is not known. OBJECTIVE AND RATIONALE The objective was to quantify the risk of adverse maternal and perinatal outcomes among twin pregnancies conceived following ART
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Driving factors in treatment decision-making of patients seeking medical assistance for infertility: a systematic review Hum. Reprod. Update (IF 14.8) Pub Date : 2024-02-02 Felicia von Estorff, Monique H Mochtar, Vicky Lehmann, Madelon van Wely
BACKGROUND ART differs in effectiveness, side-effects, administration, and costs. To improve the decision-making process, we need to understand what factors patients consider to be most important. OBJECTIVE AND RATIONALE We conducted this systematic review to assess which aspects of ART treatment (effectiveness, safety, burden, costs, patient-centeredness, and genetic parenthood) are most important
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Sexual function in women with polycystic ovary syndrome: a systematic review and meta-analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2024-01-18 Hester Pastoor, Aya Mousa, Hanneke Bolt, Wichor Bramer, Tania S Burgert, Anuja Dokras, Chau Thien Tay, Helena J Teede, Joop Laven
BACKGROUND Polycystic ovary syndrome (PCOS) is a common and distressing endocrine disorder associated with lower quality of life, subfertility, diabetes, cardiovascular disease, depression, anxiety, and eating disorders. PCOS characteristics, its comorbidities, and its treatment can potentially influence sexual function. However, studies on sexual function in women with PCOS are limited and contradictory
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Assessing the influence of preconception diet on male fertility: a systematic scoping review Hum. Reprod. Update (IF 14.8) Pub Date : 2024-01-18 Cathryn A Tully, Simon Alesi, Nicole O McPherson, David J Sharkey, Xiao Tong Teong, Chau Thien Tay, Thais Rasia Silva, Carolyn Puglisi, Jacqueline P Barsby, Lisa J Moran, Jessica A Grieger, Aya Mousa
BACKGROUND The last decade has seen increased research on the relationship between diet and male fertility, but there are no clearly defined nutritional recommendations for men in the preconception period to support clinical fertility outcomes. OBJECTIVE AND RATIONALE The purpose of this scoping review is to examine the extent and range of research undertaken to evaluate the effect(s) of diet in the
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Finding a way through the review maze: systematic, scoping, or an overview. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-01-03 Madelon van Wely
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Transcriptomic integrity of human oocytes used in ARTs: technical and intrinsic factor effects. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-01-03 Bastien Ducreux,Catherine Patrat,Jacquetta Trasler,Patricia Fauque
BACKGROUND Millions of children have been born throughout the world thanks to ARTs, the harmlessness of which has not yet been fully demonstrated. For years, efforts to evaluate the specific effects of ART have focused on the embryo; however, it is the oocyte quality that mainly dictates first and foremost the developmental potential of the future embryo. Ovarian stimulation, cryopreservation, and
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IVF versus IUI with ovarian stimulation for unexplained infertility: a collaborative individual participant data meta-analysis Hum. Reprod. Update (IF 14.8) Pub Date : 2023-12-27 Shimona Lai, Rui Wang, Madelon van Wely, Michael Costello, Cindy Farquhar, Alexandra J Bensdorp, Inge M Custers, Angelique J Goverde, Hossam Elzeiny, Ben W Mol, Wentao Li
BACKGROUND IVF and IUI with ovarian stimulation (IUI-OS) are widely used in managing unexplained infertility. IUI-OS is generally considered first-line therapy, followed by IVF only if IUI-OS is unsuccessful after several attempts. However, there is a growing interest in using IVF for immediate treatment because it is believed to lead to higher live birth rates and shorter time to pregnancy. OBJECTIVE
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Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy Hum. Reprod. Update (IF 14.8) Pub Date : 2023-12-01 Daimin Wei, Yaxin Su, Peter C K Leung, Yan Li, Zi-Jiang Chen
BACKGROUND During the human menstrual cycle and pregnancy, the endometrium undergoes a series of dynamic remodeling processes to adapt to physiological changes. Insufficient endometrial remodeling, characterized by inadequate endometrial proliferation, decidualization and spiral artery remodeling, is associated with infertility, endometriosis, dysfunctional uterine bleeding, and pregnancy-related complications
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COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-01 Janneke A C van Baar,Elena B Kostova,John Allotey,Shakila Thangaratinam,Javier R Zamora,Mercedes Bonet,Caron Rahn Kim,Lynne M Mofenson,Heinke Kunst,Asma Khalil,Elisabeth van Leeuwen,Julia Keijzer,Marije Strikwerda,Bethany Clark,Maxime Verschuuren,Arri Coomarasamy,Mariëtte Goddijn,Madelon van Wely,
BACKGROUND Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates are more likely to be stillborn or admitted to a neonatal unit. The World Health Organization declared in May 2023 an end to the coronavirus disease 2019 (COVID-19) pandemic as a global health emergency. However, pregnant women are still
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A systematic review to determine use of the Endometriosis Health Profiles to measure quality of life outcomes in women with endometriosis. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-03-01 Georgina L Jones,Kirsty Budds,Francesca Taylor,Danielle Musson,Justin Raymer,David Churchman,Stephen H Kennedy,Crispin Jenkinson
BACKGROUND The Endometriosis Health Profiles (EHPs), the EHP-30 and EHP-5, are patient-reported outcome measures that were developed to measure the health-related quality of life (HRQoL) of women living with endometriosis. Prior to their development, a systematic review was undertaken which identified that the HRQoL of women living with endometriosis was poorly understood, with only three medical and
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Ultrasonographic criteria in the diagnosis of polycystic ovary syndrome: a systematic review and diagnostic meta-analysis. Hum. Reprod. Update (IF 14.8) Pub Date : 2024-01-03 Jeffrey Pea,Jahnay Bryan,Cynthia Wan,Alexis L Oldfield,Kiran Ganga,Faith E Carter,Lynn M Johnson,Marla E Lujan
BACKGROUND Polycystic ovary morphology (PCOM) on ultrasonography is considered as a cardinal feature of polycystic ovarian syndrome (PCOS). Its relevance as a diagnostic criterion for PCOS was reaffirmed in the most recent International Evidence-Based Guideline for the Assessment and Management of PCOS. However, there remains a lack of clarity regarding the best practices and specific ultrasonographic