-
Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-06-23 Karoline E. Kokot, Jasmin M. Kneuer, David John, Sabine Rebs, Maximilian N. Möbius-Winkler, Stephan Erbe, Marion Müller, Michael Andritschke, Susanne Gaul, Bilal N. Sheikh, Jan Haas, Holger Thiele, Oliver J. Müller, Susanne Hille, Florian Leuschner, Stefanie Dimmeler, Katrin Streckfuss-Bömeke, Benjamin Meder, Ulrich Laufs, Jes-Niels Boeckel
-
Negative interaction between nitrates and remote ischemic preconditioning in patients undergoing cardiac surgery: the ERIC-GTN and ERICCA studies Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-06-21 Ashraf Hamarneh, Andrew Fu Wah Ho, Heerajnarain Bulluck, Vivek Sivaraman, Federico Ricciardi, Jennifer Nicholas, Hilary Shanahan, Elizabeth A. Hardman, Peter Wicks, Manish Ramlall, Robin Chung, John McGowan, Roger Cordery, David Lawrence, Tim Clayton, Bonnie Kyle, Maria Xenou, Cono Ariti, Derek M. Yellon, Derek J. Hausenloy
-
Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-06-08 Selin Gencer, Yvonne Döring, Yvonne Jansen, Soyolmaa Bayasgalan, Yi Yan, Mariaelvy Bianchini, Ismail Cimen, Madeleine Müller, Linsey J. F. Peters, Remco T. A. Megens, Philipp von Hundelshausen, Johan Duchene, Patricia Lemnitzer, Oliver Soehnlein, Christian Weber, Emiel P. C. van der Vorst
-
Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-05-29 Christine Quast, Frank Kober, Katrin Becker, Elric Zweck, Jasmina Hoffe, Christoph Jacoby, Vera Flocke, Isabella Gyamfi-Poku, Fabian Keyser, Kerstin Piayda, Ralf Erkens, Sven Niepmann, Matti Adam, Stephan Baldus, Sebastian Zimmer, Georg Nickenig, Maria Grandoch, Florian Bönner, Malte Kelm, Ulrich Flögel
-
Innate immune cells in the pathophysiology of calcific aortic valve disease: lessons to be learned from atherosclerotic cardiovascular disease? Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-05-17 Wieteke Broeders, Siroon Bekkering, Saloua El Messaoudi, Leo A. B. Joosten, Niels van Royen, Niels P. Riksen
-
Cardioprotection by selective SGLT-2 inhibitors in a non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect? Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-05-17 Panagiota Efstathia Nikolaou, Nikolaos Mylonas, Manousos Makridakis, Marina Makrecka-Kuka, Aikaterini Iliou, Stelios Zerikiotis, Panagiotis Efentakis, Stavros Kampoukos, Nikolaos Kostomitsopoulos, Reinis Vilskersts, Ignatios Ikonomidis, Vaia Lambadiari, Coert J. Zuurbier, Agnieszka Latosinska, Antonia Vlahou, George Dimitriadis, Efstathios K. Iliodromitis, Ioanna Andreadou
-
Neonatal injury models: integral tools to decipher the molecular basis of cardiac regeneration Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-05-03 Alessia Costa, Sarah Cushman, Bernhard J. Haubner, Anselm A. Derda, Thomas Thum, Christian Bär
-
Optogenetic manipulation of cardiac electrical dynamics using sub-threshold illumination: dissecting the role of cardiac alternans in terminating rapid rhythms Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-04-29 V. Biasci, L. Santini, G. A. Marchal, S. Hussaini, C. Ferrantini, R. Coppini, L. M. Loew, S. Luther, M. Campione, C. Poggesi, F. S. Pavone, E. Cerbai, G. Bub, L. Sacconi
-
Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-05-02 Philipp Jung, Fitzwilliam Seibertz, Funsho E. Fakuade, Nadezda Ignatyeva, Shrivatsan Sampathkumar, Melanie Ritter, Housen Li, Fleur E. Mason, Antje Ebert, Niels Voigt
-
NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-04-25 Yangjing Xie, Yoshinori Nishijima, Natalya S. Zinkevich, Ankush Korishettar, Juan Fang, Angela J. Mathison, Michael T. Zimmermann, David A. Wilcox, David D. Gutterman, Yuxian Shen, David X. Zhang
-
Effects of late, repetitive remote ischaemic conditioning on myocardial strain in patients with acute myocardial infarction Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-04-23 J. Ranjit Arnold, Andrew P.Vanezis, Glenn C. Rodrigo, Florence Y. Lai, Prathap Kanagala, Sheraz Nazir, Jamal N. Khan, Leong Ng, Kamal Chitkara, J. Gerry Coghlan, Simon Hetherington, Nilesh J. Samani, Gerald P. McCann
-
Fibro-fatty remodelling in arrhythmogenic cardiomyopathy Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-04-19 Arwa Kohela, Eva van Rooij
-
Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-04-07 Yanhong Xing, Zhongheng Sui, Yucheng Liu, Meng-meng Wang, Xiangqing Wei, Qixia Lu, Xinyan Wang, Nan Liu, Chen Lu, Rong Chen, Mengmei Wu, Yuqing Wang, Yu-hong Zhao, Feng Guo, Jun-li Cao, Jiansong Qi, Wuyang Wang
-
Regional analysis of inflammation and contractile function in reperfused acute myocardial infarction by in vivo 19F cardiovascular magnetic resonance in pigs Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-04-07 Florian Bönner, M. Gastl, F. Nienhaus, M. Rothe, A. Jahn, S. Pfeiler, U. Gross, H.-P. Schultheiss, B. Ibanez, S. Kozerke, J. Szendroedi, M. Roden, R. Westenfeld, J. Schrader, U. Flögel, G. Heusch, M. Kelm
-
Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-04-05 Zhiyan Wang, Zeping Qiu, Sha Hua, Wenbo Yang, Yanjia Chen, Fanyi Huang, Yingze Fan, Lingfeng Tong, Tianle Xu, Xuemei Tong, Ke Yang, Wei Jin
-
Publisher Correction: Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-04-05 Ling Li,Zhifen Chen,Moritz von Scheidt,Shuangyue Li,Andrea Steiner,Ulrich Güldener,Simon Koplev,Angela Ma,Ke Hao,Calvin Pan,Aldons J. Lusis,Shichao Pang,Thorsten Kessler,Raili Ermel,Katyayani Sukhavasi,Arno Ruusalepp,Julien Gagneur,Jeanette Erdmann,Jason C. Kovacic,Johan L. M. Björkegren,Heribert Schunkert
-
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-31 Alzbeta Hulikova, Kyung Chan Park, Aminah A. Loonat, Mala Gunadasa-Rohling, M. Kate Curtis, Yu Jin Chung, Abigail Wilson, Carolyn A. Carr, Andrew W. Trafford, Marjorie Fournier, Anna Moshnikova, Oleg A. Andreev, Yana K. Reshetnyak, Paul R. Riley, Nicola Smart, Thomas A. Milne, Nicholas T. Crump, Pawel Swietach
-
P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-30 Hana Seung, Jan Wrobel, Carolin Wadle, Timon Bühler, Diana Chiang, Jasmin Rettkowski, Nina Cabezas-Wallscheid, Béatrice Hechler, Peter Stachon, Alexander Maier, Christian Weber, Dennis Wolf, Daniel Duerschmied, Marco Idzko, Christoph Bode, Constantin von zur Mühlen, Ingo Hilgendorf, Timo Heidt
Emergency hematopoiesis is the driving force of the inflammatory response to myocardial infarction (MI). Increased proliferation of hematopoietic stem and progenitor cells (LSK) after MI enhances cell production in the bone marrow (BM) and replenishes leukocyte supply for local cell recruitment to the infarct. Decoding the regulation of the inflammatory cascade after MI may provide new avenues to improve
-
Chronic isoprenaline/phenylephrine vs. exclusive isoprenaline stimulation in mice: critical contribution of alpha1-adrenoceptors to early cardiac stress responses Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-14 Matthias Dewenter, Jianyuan Pan, Laura Knödler, Niklas Tzschöckel, Julian Henrich, Julio Cordero, Gergana Dobreva, Susanne Lutz, Johannes Backs, Thomas Wieland, Christiane Vettel
Hyperactivity of the sympathetic nervous system is a major driver of cardiac remodeling, exerting its effects through both α-, and β-adrenoceptors (α-, β-ARs). As the relative contribution of subtype α1-AR to cardiac stress responses remains poorly investigated, we subjected mice to either subcutaneous perfusion with the β-AR agonist isoprenaline (ISO, 30 mg/kg × day) or to a combination of ISO and
-
Characterizing the transition from immune response to tissue repair after myocardial infarction by multiparametric imaging Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-11 Annika Hess, Tobias Borchert, Tobias L. Ross, Frank M. Bengel, James T. Thackeray
Persistent inflammation following myocardial infarction (MI) precipitates adverse outcome including acute ventricular rupture and chronic heart failure. Molecular imaging allows longitudinal assessment of immune cell activity in the infarct territory and predicts severity of remodeling. We utilized a multiparametric imaging platform to assess the immune response and cardiac healing following MI in
-
Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-08 Luis Peter Haupt, Sabine Rebs, Wiebke Maurer, Daniela Hübscher, Malte Tiburcy, Steffen Pabel, Andreas Maus, Steffen Köhne, Rewati Tappu, Jan Haas, Yun Li, Andre Sasse, Celio C. X. Santos, Ralf Dressel, Leszek Wojnowski, Gertrude Bunt, Wiebke Möbius, Ajay M. Shah, Benjamin Meder, Bernd Wollnik, Samuel Sossalla, Gerd Hasenfuss, Katrin Streckfuss-Bömeke
Cancer therapies with anthracyclines have been shown to induce cardiovascular complications. The aims of this study were to establish an in vitro induced pluripotent stem cell model (iPSC) of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and to examine whether doxorubicin (DOX)-treated ACT-iPSC cardiomyocytes (CM) can recapitulate the clinical features
-
On the cellular origin of cardiosphere-derived cells (CDCs). Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-08 Eduardo Marbán,Ke Liao
-
Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-08 Palgit-S. Kogan, Felix Wirth, Archana Tomar, Jonatan Darr, Raffaele Teperino, Harald Lahm, Martina Dreßen, Nazan Puluca, Zhong Zhang, Irina Neb, Nicole Beck, Tatjana Luzius, Luis de la Osa de la Rosa, Kathrin Gärtner, Corinna Hüls, Reinhard Zeidler, Deepak Ramanujam, Stefan Engelhardt, Catharina Wenk, Lesca M. Holdt, Mimmi Mononen, Makoto Sahara, Julie Cleuziou, Jürgen Hörer, Rüdiger Lange, Markus
Cardiosphere-derived cells (CDCs) generated from human cardiac biopsies have been shown to have disease-modifying bioactivity in clinical trials. Paradoxically, CDCs’ cellular origin in the heart remains elusive. We studied the molecular identity of CDCs using single-cell RNA sequencing (sc-RNAseq) in comparison to cardiac non-myocyte and non-hematopoietic cells (cardiac fibroblasts/CFs, smooth muscle
-
Loss of NPPA-AS1 promotes heart regeneration by stabilizing SFPQ–NONO heteromer-induced DNA repair Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-05 Wenbin Fu, Hongmei Ren, Jialing Shou, Qiao Liao, Liangpeng Li, Yu Shi, Pedro A. Jose, Chunyu Zeng, Wei Eric Wang
The role of long non-coding RNA (lncRNA) in endogenous cardiac regeneration remains largely elusive. The mammalian cardiomyocyte is capable of regeneration for a brief period after birth. This fact allows the exploration of the roles of critical lncRNAs in the regulation of cardiac regeneration. Through a cardiac regeneration model by apical resection (AR) of the left ventricle in neonatal mice, we
-
Development and characterization of anti-fibrotic natural compound similars with improved effectivity Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-02 Fabian Philipp Kreutzer, Anna Meinecke, Saskia Mitzka, Hannah Jill Hunkler, Lisa Hobuß, Naisam Abbas, Robert Geffers, Jan Weusthoff, Ke Xiao, Danny David Jonigk, Jan Fiedler, Thomas Thum
Cardiac fibroblasts constitute the major cell type of the murine and human heart. Once activated, they contribute to an excessive deposition of extracellular matrix (ECM) leading to cardiac fibrosis and subsequently organ dysfunction. With the exception of the pulmonary drugs, nintedanib and pirfenidone, drugs specifically targeting anti-fibrotic pathways are scarce. We recently performed large library
-
RGS3L allows for an M2 muscarinic receptor-mediated RhoA-dependent inotropy in cardiomyocytes Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-03-01 Magdolna K. Levay, Kurt A. Krobert, Andreas Vogt, Atif Ahmad, Andreas Jungmann, Christiane Neuber, Sebastian Pasch, Arne Hansen, Oliver J. Müller, Susanne Lutz, Thomas Wieland
The role and outcome of the muscarinic M2 acetylcholine receptor (M2R) signaling in healthy and diseased cardiomyocytes is still a matter of debate. Here, we report that the long isoform of the regulator of G protein signaling 3 (RGS3L) functions as a switch in the muscarinic signaling, most likely of the M2R, in primary cardiomyocytes. High levels of RGS3L, as found in heart failure, redirect the
-
Correction to: Endothelial actions of atrial natriuretic peptide prevent pulmonary hypertension in mice Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-02-28 Franziska Werner,Baktybek Kojonazarov,Birgit Gaßner,Marco Abeßer,Kai Schuh,Katharina Völker,Hideo A. Baba,Bhola K. Dahal,Ralph T. Schermuly,Michaela Kuhn
-
Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-02-17 Ling Li, Zhifen Chen, Moritz von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, Aldons J. Lusis, Shichao Pang, Thorsten Kessler, Raili Ermel, Katyayani Sukhavasi, Arno Ruusalepp, Julien Gagneur, Jeanette Erdmann, Jason C. Kovacic, Johan L. M. Björkegren, Heribert Schunkert
The majority of risk loci identified by genome-wide association studies (GWAS) are in non-coding regions, hampering their functional interpretation. Instead, transcriptome-wide association studies (TWAS) identify gene-trait associations, which can be used to prioritize candidate genes in disease-relevant tissue(s). Here, we aimed to systematically identify susceptibility genes for coronary artery disease
-
Reverse re-modelling chronic heart failure by reinstating heart rate variability Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-02-01 J. Shanks, Y. Abukar, N. A. Lever, M. Pachen, I. J. LeGrice, D. J. Crossman, A. Nogaret, J. F. R. Paton, R. Ramchandra
Heart rate variability (HRV) is a crucial indicator of cardiovascular health. Low HRV is correlated with disease severity and mortality in heart failure. Heart rate increases and decreases with each breath in normal physiology termed respiratory sinus arrhythmia (RSA). RSA is highly evolutionarily conserved, most prominent in the young and athletic and is lost in cardiovascular disease. Despite this
-
Mitochondrial DNA integrity and function are critical for endothelium-dependent vasodilation in rats with metabolic syndrome Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-01-17 Kiyooka, Takahiko, Ohanyan, Vahagn, Yin, Liya, Pung, Yuh Fen, Chen, Yeong-Renn, Chen, Chwen-Lih, Kang, Patrick T., Hardwick, James P., Yun, June, Janota, Danielle, Peng, Joanna, Kolz, Christopher, Guarini, Giacinta, Wilson, Glenn, Shokolenko, Inna, Stevens, Donte A., Chilian, William M.
Endothelial dysfunction in diabetes is generally attributed to oxidative stress, but this view is challenged by observations showing antioxidants do not eliminate diabetic vasculopathy. As an alternative to oxidative stress-induced dysfunction, we interrogated if impaired mitochondrial function in endothelial cells is central to endothelial dysfunction in the metabolic syndrome. We observed reduced
-
Coronary blood flow in heart failure: cause, consequence and bystander Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-01-13 Heusch, Gerd
Heart failure is a clinical syndrome where cardiac output is not sufficient to sustain adequate perfusion and normal bodily functions, initially during exercise and in more severe forms also at rest. The two most frequent forms are heart failure of ischemic origin and of non-ischemic origin. In heart failure of ischemic origin, reduced coronary blood flow is causal to cardiac contractile dysfunction
-
Mechanism of the switch from NO to H2O2 in endothelium-dependent vasodilation in diabetes Basic Res. Cardiol. (IF 17.165) Pub Date : 2022-01-13 Juguilon, Cody, Wang, Zhiyuan, Wang, Yang, Enrick, Molly, Jamaiyar, Anurag, Xu, Yanyong, Gadd, James, Chen, Chwen-Lih W., Pu, Autumn, Kolz, Chris, Ohanyan, Vahagn, Chen, Yeong-Renn, Hardwick, James, Zhang, Yanqiao, Chilian, William M., Yin, Liya
Coronary microvascular dysfunction is prevalent among people with diabetes and is correlated with cardiac mortality. Compromised endothelial-dependent dilation (EDD) is an early event in the progression of diabetes, but its mechanisms remain incompletely understood. Nitric oxide (NO) is the major endothelium-dependent vasodilatory metabolite in the healthy coronary circulation, but this switches to
-
Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-12-23 Boulghobra, Doria, Dubois, Mathilde, Alpha-Bazin, Béatrice, Coste, Florence, Olmos, Maxime, Gayrard, Sandrine, Bornard, Isabelle, Meyer, Gregory, Gaillard, Jean-Charles, Armengaud, Jean, Reboul, Cyril
Endothelial nitric oxide synthase (eNOS) activation in the heart plays a key role in exercise-induced cardioprotection during ischemia–reperfusion, but the underlying mechanisms remain unknown. We hypothesized that the cardioprotective effect of exercise training could be explained by the re-localization of eNOS-dependent nitric oxide (NO)/S-nitrosylation signaling to mitochondria. By comparing exercised
-
Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia–reperfusion injury Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-12-16 Li, Su, Chen, Jinxiang, Liu, Muyin, Chen, Yuqiong, Wu, Yuan, Li, Qiyu, Ma, Teng, Gao, Jinfeng, Xia, Yan, Fan, Mengkang, Chen, Ao, Lu, Danbo, Su, Enyong, Xu, Fei, Chen, Zhangwei, Qian, Juying, Ge, Junbo
Current evidence indicates that coronary microcirculation is a key target for protecting against cardiac ischemia–reperfusion (I/R) injury. Mitochondrial calcium uniporter (MCU) complex activation and mitochondrial calcium ([Ca2+]m) overload are underlying mechanisms involved in cardiovascular disease. Histidine triad nucleotide-binding 2 (HINT2) has been reported to modulate [Ca2+]m via the MCU complex
-
Single-cell transcriptomic identified HIF1A as a target for attenuating acute rejection after heart transplantation Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-12-06 Chang, Yuan, Li, Xiangjie, Cheng, Qi, Hu, Yiqing, Chen, Xiao, Hua, Xiumeng, Fan, Xuexin, Tao, Menghao, Song, Jiangping, Hu, Shengshou
Acute rejection (AR) is an important contributor to graft failure, which remains a leading cause of death after heart transplantation (HTX). The regulation of immune metabolism has become a new hotspot in the development of immunosuppressive drugs. In this study, Increased glucose metabolism of cardiac macrophages was found in patients with AR. To find new therapeutic targets of immune metabolism regulation
-
Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-28 Bogdanov, Vladimir, Soltisz, Andrew M., Moise, Nicolae, Sakuta, Galina, Orengo, Benjamin Hernandez, Janssen, Paul M. L., Weinberg, Seth H., Davis, Jonathan P., Veeraraghavan, Rengasayee, Györke, Sandor
It is widely assumed that synthesis of membrane proteins, particularly in the heart, follows the classical secretory pathway with mRNA translation occurring in perinuclear regions followed by protein trafficking to sites of deployment. However, this view is based on studies conducted in less-specialized cells, and has not been experimentally addressed in cardiac myocytes. Therefore, we undertook direct
-
Anthracycline-free tumor elimination in mice leads to functional and molecular cardiac recovery from cancer-induced alterations in contrast to long-lasting doxorubicin treatment effects Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-20 Pietzsch, Stefan, Wohlan, Katharina, Thackeray, James T., Heimerl, Maren, Schuchardt, Sven, Scherr, Michaela, Ricke-Hoch, Melanie, Hilfiker-Kleiner, Denise
Systemic effects of advanced cancer impact on the heart leading to cardiac atrophy and functional impairment. Using a murine melanoma cancer model (B16F10 melanoma cells stably transduced with a Ganciclovir (GCV)-inducible suicide gene), the present study analysed the recovery potential of cancer-induced cardiomyopathy with or without use of doxorubicin (Dox). After Dox-free tumor elimination and recovery
-
Cardiac dysfunction from cancer and cancer therapy: new pathways for the prevention of late cardiotoxicity. Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-20 Lars Michel,Matthias Totzeck,Tienush Rassaf
-
Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-14 Francis, Rohin, Chong, Jun, Ramlall, Manish, Bucciarelli-Ducci, Chiara, Clayton, Tim, Dodd, Matthew, Engstrøm, Thomas, Evans, Richard, Ferreira, Vanessa M., Fontana, Marianna, Greenwood, John P., Kharbanda, Rajesh K., Kim, Won Yong, Kotecha, Tushar, Lønborg, Jacob T., Mathur, Anthony, Møller, Ulla Kristine, Moon, James, Perkins, Alexander, Rakhit, Roby D., Yellon, Derek M., Bøtker, Hans Erik, Bulluck
The effect of limb remote ischaemic conditioning (RIC) on myocardial infarct (MI) size and left ventricular ejection fraction (LVEF) was investigated in a pre-planned cardiovascular magnetic resonance (CMR) substudy of the CONDI-2/ERIC-PPCI trial. This single-blind multi-centre trial (7 sites in UK and Denmark) included 169 ST-segment elevation myocardial infarction (STEMI) patients who were already
-
Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-14 Hegyi, Bence, Pölönen, Risto-Pekka, Hellgren, Kim T., Ko, Christopher Y., Ginsburg, Kenneth S., Bossuyt, Julie, Mercola, Mark, Bers, Donald M.
Cardiomyocyte Na+ and Ca2+ mishandling, upregulated Ca2+/calmodulin-dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are characteristics of various heart diseases, including heart failure (HF), long QT (LQT) syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPVT). These changes may form a vicious cycle of positive feedback to promote cardiac dysfunction and
-
Effects of remote ischemic preconditioning (RIPC) and chronic remote ischemic preconditioning (cRIPC) on levels of plasma cytokines, cell surface characteristics of monocytes and in-vitro angiogenesis: a pilot study Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-14 Hummitzsch, Lars, Zitta, Karina, Fritze, Lena, Monnens, Jonas, Vollertsen, Patrick, Lindner, Matthias, Rusch, Rene, Hess, Katharina, Gruenewald, Matthias, Steinfath, Markus, Fändrich, Fred, Berndt, Rouven, Albrecht, Martin
Remote ischemic preconditioning (RIPC) protects the heart against myocardial ischemia/reperfusion (I/R) injury and recent work also suggested chronic remote ischemic conditioning (cRIPC) for cardiovascular protection. Based on current knowledge that systemic immunomodulatory effects of RIPC and the anti-inflammatory capacity of monocytes might be involved in cardiovascular protection, the aim of our
-
Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-13 Orth-Alampour, Setareh, Gayrard, Nathalie, Salem, Silvia, Bhargava, Shruti, Jankowski, Vera, Jover, Bernard, Notarnicola, Cécile, Noels, Heidi, van der Vorst, Emiel P. C., Kuppe, Christoph, Wolf, Michael, Goettsch, Claudia, Theelen, Wendy, Bruck, Heike, Fliser, Danilo, Loscalzo, Joseph, Wu, Zhuojun, Marx, Nikolaus, Zidek, Walter, Argilés, Àngel, Jankowski, Joachim
The adrenal glands participate in cardiovascular (CV) physiology and the pathophysiology of CV diseases through their effects on sodium and water metabolism, vascular tone and cardiac function. In the present study, we identified a new adrenal compound controlling mesenchymal cell differentiation that regulates osteoblastic differentiation in the context of vascular calcification. This peptide was
-
Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-12 Comità, Stefano, Femmino, Saveria, Thairi, Cecilia, Alloatti, Giuseppe, Boengler, Kerstin, Pagliaro, Pasquale, Penna, Claudia
Ischemia–reperfusion injury (IRI) is one of the biggest challenges for cardiovascular researchers given the huge death toll caused by myocardial ischemic disease. Cardioprotective conditioning strategies, namely pre- and post-conditioning maneuvers, represent the most important strategies for stimulating pro-survival pathways essential to preserve cardiac health. Conditioning maneuvers have proved
-
Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-10-03 Rao, Man, Wang, Xiliang, Guo, Guangran, Wang, Li, Chen, Shi, Yin, Pengbin, Chen, Kai, Chen, Liang, Zhang, Zemin, Chen, Xiao, Hu, Xueda, Hu, Shengshou, Song, Jiangping
Inflammation and fibrosis are intertwined mechanisms fundamentally involved in heart failure. Detailed deciphering gene expression perturbations and cell–cell interactions of leukocytes and non-myocytes is required to understand cell-type-specific pathology in the failing human myocardium. To this end, we performed single-cell RNA sequencing and single T cell receptor sequencing of 200,615 cells in
-
The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-09-28 Zhang, Hualu, Yang, Ningzhi, He, Haiyan, Chai, Junwu, Cheng, Xinxin, Zhao, Huanhuan, Zhou, Dongming, Teng, Tianming, Kong, Xiangrong, Yang, Qing, Xu, Zhelong
Whereas elimination of damaged mitochondria by mitophagy is proposed to be cardioprotective, the regulation of mitophagy at reperfusion and the underlying mechanism remain elusive. Since mitochondrial Zn2+ may control mitophagy by regulating mitochondrial membrane potential (MMP), we hypothesized that the zinc transporter ZIP7 that controls Zn2+ levels within mitochondria would contribute to reperfusion
-
The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-09-21 Bai, Yongyi, Wang, Jingrong, Chen, Ying, Lv, Tingting, Wang, Xiaojian, Liu, Chunlei, Xue, Hao, He, Kunlun, Sun, Lan
We recently identified oncologic miR-182 as a new regulator of pulmonary artery hypertension (PAH) that targets myeloid-associated differentiation marker (Myadm), which is expressed in bone marrow stem cells and multipotent progenitors. Both miR-182 and Myadm are expressed in the cardiopulmonary system and correlated with the balance between the bone morphogenetic protein (BMP) and the transforming
-
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-09-13 Lecour, Sandrine, Andreadou, Ioanna, Bøtker, Hans Erik, Davidson, Sean M., Heusch, Gerd, Ruiz-Meana, Marisol, Schulz, Rainer, Zuurbier, Coert J., Ferdinandy, Péter, Hausenloy, Derek J.
Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new therapeutic interventions are still needed to protect the heart against acute ischemia/reperfusion injury to reduce myocardial infarct size and prevent the onset of HF in patients presenting with AMI. However, the clinical translation of cardioprotective
-
Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-09-12 van de Wouw, Jens, Steenhorst, Jarno J., Sorop, Oana, van Drie, Ruben W. A., Wielopolski, Piotr A., Kleinjan, Alex, Hirsch, Alexander, Duncker, Dirk J., Merkus, Daphne
Pulmonary hypertension is common in heart failure with preserved ejection fraction (HFpEF). Here, we tested the hypothesis that comorbidities [diabetes mellitus (DM, streptozotocin), hypercholesterolemia (HC, high-fat diet) and chronic kidney disease (CKD, renal microembolization)] directly impair pulmonary vasomotor control in a DM + HC + CKD swine model. 6 months after induction of DM + HC + CKD
-
Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-08-26 van de Wouw, Jens, Sorop, Oana, van Drie, Ruben W. A., Joles, Jaap A., Danser, A. H. Jan, Verhaar, Marianne C., Merkus, Daphne, Duncker, Dirk J.
In the present study, we tested the hypothesis that multiple risk factors, including diabetes mellitus (DM), dyslipidaemia and chronic kidney disease (CKD) result in a loss of nitric oxide (NO) signalling, thereby contributing to coronary microvascular dysfunction. Risk factors were induced in 12 female swine by intravenous streptozotocin injections (DM), a high fat diet (HFD) and renal artery embolization
-
Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-08-14 Feng, Yuliang, Huang, Wei, Paul, Christian, Liu, Xingguo, Sadayappan, Sakthivel, Wang, Yigang, Pauklin, Siim
Metabolic function and energy production in eukaryotic cells are regulated by mitochondria, which have been recognized as the intracellular ‘powerhouses’ of eukaryotic cells for their regulation of cellular homeostasis. Mitochondrial function is important not only in normal developmental and physiological processes, but also in a variety of human pathologies, including cardiac diseases. An emerging
-
LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-08-11 Liu, Ning, Kataoka, Masaharu, Wang, Yingchao, Pu, Linbin, Dong, Xiaoxuan, Fu, Xuyang, Zhang, Feng, Gao, Feng, Liang, Tian, Pei, Jianqiu, Xiao, Changchen, Qiu, Qiongzi, Hong, Tingting, Chen, Qiming, Zhao, Jing, Zhu, Lianlian, He, Junhua, Hu, Xiaoyun, Nie, Yu, Zhu, Wei, Yu, Hong, Cowan, Douglas B., Hu, Xinyang, Wang, Jian’an, Wang, Da-Zhi, Chen, Jinghai
Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling of the ischemic heart. Because little is known about the involvement of long non-coding RNAs (lncRNAs) in regulating cardiac metabolism, we used unbiased transcriptome profiling in a mouse model of myocardial infarction (MI). We identified a novel cardiomyocyte-enriched lncRNA, called LncHrt, which regulates metabolism
-
Atg5 knockdown induces age-dependent cardiomyopathy which can be rescued by repeated remote ischemic conditioning Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-07-28 Wang, Fangfei, He, Quan, Gao, Zhiqian, Redington, Andrew N.
Altered autophagy is implicated in several human cardiovascular diseases. Remote ischemic conditioning (RIC) is cardioprotective in multiple cardiovascular injury models and modifies autophagy signaling, but its effect in cardiomyopathy induced by gene manipulation has not been reported. To investigate the cardiac effects of chronically reduced autophagy as a result of Atg5 knockdown and assess whether
-
Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-07-24 Jiao Jiao, Shujie He, Yiqiu Wang, Yuzhi Lu, Muyang Gu, Dan Li, Tingting Tang, Shaofang Nie, Min Zhang, Bingjie Lv, Jingyong Li, Ni Xia, Xiang Cheng
Overactivated inflammatory responses contribute to adverse ventricular remodeling after myocardial infarction (MI). Regulatory B cells (Bregs) are a newly discovered subset of B cells with immunomodulatory roles in many immune and inflammation-related diseases. Our study aims to determine whether the expansion of Bregs exerts a beneficial effect on ventricular remodeling and explore the mechanisms
-
Intravenous metoprolol during ongoing STEMI ameliorates markers of ischemic injury: a METOCARD-CNIC trial electrocardiographic study Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-07-19 Raquel Díaz-Munoz, María José Valle-Caballero, Javier Sanchez-Gonzalez, Gonzalo Pizarro, Juan Carlos García-Rubira, Noemi Escalera, Valentin Fuster, Rodrigo Fernández-Jiménez, Borja Ibanez
Besides its protective effect against neutrophil-mediated injury at reperfusion, intravenous (IV) metoprolol was recently shown to reduce the progression of ischemic injury in a pig model of ST-segment elevation myocardial infarction (STEMI). Here, we tested the hypothesis that IV metoprolol administration in humans with ongoing STEMI blunts the time‑dependent progression of ischemic injury assessed
-
Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-07-17 Ioanna Andreadou, Panagiotis Efentakis, Katie Frenis, Andreas Daiber, Rainer Schulz
Thiol-based redox compounds, namely thioredoxins (Trxs), glutaredoxins (Grxs) and peroxiredoxins (Prxs), stand as a pivotal group of proteins involved in antioxidant processes and redox signaling. Glutaredoxins (Grxs) are considered as one of the major families of proteins involved in redox regulation by removal of S-glutathionylation and thereby reactivation of other enzymes with thiol-dependent activity
-
Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-07-05 Julian U. G. Wagner, Denisa Bojkova, Mariana Shumliakivska, Guillermo Luxán, Luka Nicin, Galip S. Aslan, Hendrik Milting, Joshua D. Kandler, Andreas Dendorfer, Andreas W. Heumueller, Ingrid Fleming, Sofia-Iris Bibli, Tobias Jakobi, Christoph Dieterich, Andreas M. Zeiher, Sandra Ciesek, Jindrich Cinatl, Stefanie Dimmeler
Coronavirus disease 2019 (COVID-19) spawned a global health crisis in late 2019 and is caused by the novel coronavirus SARS-CoV-2. SARS-CoV-2 infection can lead to elevated markers of endothelial dysfunction associated with higher risk of mortality. It is unclear whether endothelial dysfunction is caused by direct infection of endothelial cells or is mainly secondary to inflammation. Here, we investigate
-
What the HEC happens around the heart during COVID-19? Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-07-05 Mirko Trilling
-
Exercise-induced peptide TAG-23 protects cardiomyocytes from reperfusion injury through regulating PKG–cCbl interaction Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-06-25 Zijie Cheng, Hao Zhang, Li Zhang, Xuejun Wang, Qijun Zhang, Mengwen Feng, Deliang Hu, Hua Li, Lingmei Qian
Recent studies have revealed that proper exercise can reduce the risk of chronic disease and is beneficial to the body. Peptides have been shown to play an important role in various pathological processes, including cardiovascular diseases. However, little is known about the role of exercise-induced peptides in cardiovascular disease. We aimed to explore the function and mechanism of TAG-23 peptide
-
Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-06-08 Jonas Gregorius, Chen Wang, Oumaima Stambouli, Tanja Hussner, Yachao Qi, Tobias Tertel, Verena Börger, Ayan Mohamud Yusuf, Nina Hagemann, Dongpei Yin, Robin Dittrich, Yanis Mouloud, Fabian D. Mairinger, Fouzi El Magraoui, Aurel Popa-Wagner, Christoph Kleinschnitz, Thorsten R. Doeppner, Matthias Gunzer, Helmut E. Meyer, Bernd Giebel, Dirk M. Hermann
Obtained from the right cell-type, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) promote stroke recovery. Within this process, microvascular remodeling plays a central role. Herein, we evaluated the effects of MSC-sEVs on the proliferation, migration, and tube formation of human cerebral microvascular endothelial cells (hCMEC/D3) in vitro and on post-ischemic angiogenesis
-
AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure Basic Res. Cardiol. (IF 17.165) Pub Date : 2021-06-04 Anca Remes, Andreas H. Wagner, Nesrin Schmiedel, Markus Heckmann, Theresa Ruf, Lin Ding, Andreas Jungmann, Frauke Senger, Hugo A. Katus, Nina D. Ullrich, Norbert Frey, Markus Hecker, Oliver J. Müller
Previous studies have underlined the substantial role of nuclear factor of activated T cells (NFAT) in hypertension-induced myocardial hypertrophy ultimately leading to heart failure. Here, we aimed at neutralizing four members of the NFAT family of transcription factors as a therapeutic strategy for myocardial hypertrophy transiting to heart failure through AAV-mediated cardiac expression of a RNA-based