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Elevated nutrient availability enhances chondrocyte metabolism and biosynthesis in tissue-engineered cartilage Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-12 Roberto Tarantino, Halie Mei Jensen, Stephen D. Waldman
Chondrocytes, which typically rely on anaerobic metabolism, exhibit upregulated biosynthetic activity when subjected to conditions that elicit mixed aerobic-anaerobic metabolism. Previously, we observed that increasing media volume resulted in the transition from anaerobic to mixed aerobic-anaerobic metabolism. Maximal extracellular matrix (ECM) accumulation occurred at this transition as a result
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Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-09 Min Kyu, Mark Kim, Matthew Lawrence, Diana Quinonez, Courtney Brooks, Rithwik Ramachandran, Cheryle A. Séguin
Transient receptor potential vanilloid 4 (TRPV4) is a multi-modally activated cation channel that mediates mechanotransduction pathways by which musculoskeletal tissues respond to mechanical load and regulate tissue health. Using conditional knockout mice, we investigated the role of in regulating intervertebral disc (IVD) health and injury-induced IVD degeneration. ( KO) mice were used to knockout
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Sex differences in osteoarthritis prevalence, pain perception, physical function and therapeutics Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-06 Neil A. Segal, Jeannine M. Nilges, Win Min Oo
Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses than men. However, the underlying factors and therapeutic outcomes of these sex-specific differences are incompletely researched. This review examines the current state of knowledge regarding sex differences in OA prevalence, risk factors, pain severity, functional outcomes, and use and response to therapeutics. PubMed
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Pioneering a chick embryo model to explore the intrauterine etiology of developmental dysplasia of the hip in oligohydramnios conditions Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-06 Shaoting Luo, Yufan Chen, Weizheng Zhou, Federico Canavese, Lianyong Li
To explore the impact of oligohydramnios on fetal movement and hip development, given its association with developmental dysplasia of the hip (DDH) but unclear mechanisms. Chick embryos were divided into four groups based on the severity of oligohydramnios induced by amniotic fluid aspiration (control, 0.2 mL, 0.4 mL, 0.6 mL). Fetal movement was assessed by detection of movement and quantification
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Exploring the association of gender role expectations of pain and measures of pain sensitization in people with knee osteoarthritis: A cross-sectional study Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-02 Y.V. Raghava Neelapala, Saurab Sharma, Lisa C. Carlesso
First, we explored the association between Gender Role Expectations of Pain (GREP), and psychophysical measures of sensitization in people with knee osteoarthritis (OA). Second, we explored whether the association differed by level of GREP items (high vs low scores). We conducted secondary analyses of a cohort study. Those who were (i) age of ≥40, English or French speaking, ii) diagnosed with knee
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Post-traumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: Secondary analysis of a randomized controlled trial Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-02 Sabine J.A. van der Graaff, Edwin H.G. Oei, Max Reijman, Lars Steenbekkers, Marienke van Middelkoop, Rianne A. van der Heijden, Duncan E. Meuffels, STARR Study Group
To assess the presence of early degenerative changes on Magnetic Resonance Imaging (MRI) 24 months after a traumatic meniscal tear and to compare these changes in patients treated with arthroscopic partial meniscectomy or physical therapy plus optional delayed arthroscopic partial meniscectomy. We included patients aged 18–45 years with a recent onset, traumatic, MRI verified, isolated meniscal tear
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Studies on postoperative outcome prognostic factors reveal intrinsic nature of osteoarthritis as a systemic disease: Comment on Osteoarthritis and Cartilage 2023;24(1):98–107 Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-29 E.V. Tchetina, E.A. Taskina
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One leg testing in hip and knee osteoarthritis: A comparison with a two-leg oriented functional outcome measure and self-reported functional measures Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-27 R. Bendrik, B. Sundström, K. Bröms, M. Emtner, LV Kallings, M. Peterson
To compare the responsiveness of two unilateral lower-limb performance-based tests, the one-leg rise test and the maximal step-up test, with the bilateral 30-second chair-stand test and the self-reported measure of physical function (HOOS/KOOS). Specific aims were to evaluate responsiveness, floor/ceiling effect and association between the instruments. Data was included from 111 participants, mean
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Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Ravi K. Komaravolu, Padmaja Mehta-D’souza, Taylor Conner, Madeline Allen, Jessica Lumry, Albert Batushansky, Nathan P. Pezant, Courtney G. Montgomery, Timothy M. Griffin
Metabolic processes are intricately linked to the resolution of innate inflammation and tissue repair, two critical steps for treating post-traumatic osteoarthritis (PTOA). Based on lipolytic and immunoregulatory actions of norepinephrine, we hypothesized that intra-articular β-adrenergic receptor (βAR) stimulation would suppress PTOA-associated inflammation in the infrapatellar fat pad (IFP) and synovium
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In response to comment from E. V. Tchetina and E. A. Taskina re. ‘Association of synovial fluid and urinary C2C-HUSA levels with surgical outcomes post-total knee arthroplasty’ Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Jason S. Rockel, Amit Sandhu, Osvaldo Espin-Garcia, A. Robin Poole, Mohit Kapoor
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Response to commentary by Dvir-Ginzberg et al. Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Paula A. Hernandez
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Do we understand sex-related differences governing dimorphic disease mechanisms in preclinical animal models of osteoarthritis? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-24 Mona Dvir-Ginzberg, Yonathan H. Maatuf, Ali Mobasheri
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Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activation Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-15 R. Castro-Viñuelas, N. Viudes-Sarrión, A.V. Rojo-García, S. Monteagudo, R.J. Lories, I. Jonkers
Optimizing rehabilitation strategies for osteoarthritis necessitates a comprehensive understanding of chondrocytes’ mechanoresponse in both health and disease, especially in the context of the interplay between loading and key pathways involved in osteoarthritis (OA) development, like canonical Wnt signaling. This study aims to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy
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Exercise for knee osteoarthritis pain: Association or causation? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-13 Marius Henriksen, Jos Runhaar, Aleksandra Turkiewicz, Martin Englund
Exercise is universally recommended as a primary strategy for the management of knee osteoarthritis (OA) pain. The recommendations are based on results from more than 100 randomized controlled trials (RCTs) that compare exercise to no-attention control groups. However, due to the inherent difficulties with adequate placebo control, participant blinding and the use of patient-reported outcomes, the
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Appraisal of quality and analysis of the similarities and differences between osteoarthritis Clinical Practice Guideline recommendations: A systematic review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-05 Bimbi Gray, Alison Gibbs, Jocelyn L. Bowden, Jillian P. Eyles, Sandra Grace, Kim Bennell, Rinie Geenen, Sharon Kolasinski, Christian Barton, Philip G. Conaghan, Timothy McAlindon, Olivier Bruyere, Quentin Géczy, David J. Hunter
Clinical Practice Guidelines (CPGs) aim to support management of hip and knee osteoarthritis (OA), but recommendations are often conflicting and implementation is poor, contributing to evidence-to-practice gaps. This systematic review investigated the contextual and methodological factors contributing to conflicting recommendations for hip and knee OA. Our systematic review appraised CPGs for managing
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Exploratory neutron tomography of articular cartilage Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-04 E. Tobias B. Wrammerfors, Elin Törnquist, Maria Pierantoni, Amanda Sjögren, Alessandro Tengattini, Anders Kaestner, René in ’t Zandt, Martin Englund, Hanna Isaksson
To investigate the feasibility of using neutron tomography to gain new knowledge of human articular cartilage degeneration in osteoarthritis (OA). Different sample preparation techniques were evaluated to identify maximum intra-tissue contrast. Human articular cartilage samples from 14 deceased donors (18–75 years, 9 males, 5 females) and 4 patients undergoing total knee replacement due to known OA
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Hip contact forces can be predicted with a neural network using only synthesised key points and electromyography in people with hip osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Bradley M. Cornish, Claudio Pizzolato, David J. Saxby, Zhengliang Xia, Daniel Devaprakash, Laura E. Diamond
To develop and validate a neural network to estimate hip contact forces (HCF), and lower body kinematics and kinetics during walking in individuals with hip osteoarthritis (OA) using synthesised anatomical key points and electromyography. To assess the capability of the neural network to detect directional changes in HCF resulting from prescribed gait modifications. A calibrated electromyography-informed
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Modulation of early osteoarthritis by tibiofemoral re-alignment in sheep Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Jan Reinhard, Tamás Oláh, Matthias W. Laschke, Lars K.H. Goebel, Gertrud Schmitt, Susanne Speicher-Mentges, Michael D. Menger, Magali Cucchiarini, Dietrich Pape, Henning Madry
To investigate whether tibiofemoral alignment influences early knee osteoarthritis (OA). We hypothesized that varus overload exacerbates early degenerative osteochondral changes, and that valgus underload diminishes early OA. Normal, over- and underload were induced by altering alignment via high tibial osteotomy in adult sheep (n = 8 each). Simultaneously, OA was induced by partial medial anterior
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Timing is everything: Towards classification criteria for early-stage symptomatic knee osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-02 Armaghan Mahmoudian, Lauren K. King, Jean W. Liew, Qiuke Wang, C. Thomas Appleton, Martin Englund, Ida K. Haugen, L. Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, Tuhina Neogi, Gillian A. Hawker, on behalf of the OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative
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Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-01 Katherine M. Arnold, Samantha R. Weaver, Elizabeth L. Zars, Daniel J. Tschumperlin, Jennifer J. Westendorf
Phlpp1 inhibition is a potential therapeutic strategy for cartilage regeneration and prevention of post-traumatic osteoarthritis (PTOA). To understand how Phlpp1 loss affects cartilage structure, cartilage elastic modulus was measured with atomic force microscopy (AFM) in male and female mice after injury. Osteoarthritis was induced in male and female Wildtype (WT) and Phlpp1 mice by destabilization
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Evolution and advancements in genomics and epigenomics in OA research: How far we have come Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-28 Yolande F.M. Ramos, Sarah J. Rice, Shabana Amanda Ali, Chiara Pastrello, Igor Jurisica, Muhammad Farooq Rai, Kelsey H. Collins, Annemarie Lang, Tristan Maerz, Jeroen Geurts, Cristina Ruiz-Romero, Ronald K. June, C. Thomas Appleton, Jason S. Rockel, Mohit Kapoor
Osteoarthritis (OA) is the most prevalent musculoskeletal disease affecting articulating joint tissues, resulting in local and systemic changes that contribute to increased pain and reduced function. Diverse technological advancements have culminated in the advent of high throughput “omic” technologies, enabling identification of comprehensive changes in molecular mediators associated with the disease
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A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-24 Holly L. Stewart, Derek Gilbert, Darko Stefanovski, Zoe Garman, Michael B. Albro, Manish Bais, Mark W. Grinstaff, Brian D. Snyder, Thomas P. Schaer
The objective was to critically analyze the published literature accounting for sex differences and skeletal age (open vs. closed physis) in preclinical animal models of OA, including the disaggregation of data by sex and skeletal maturity when data is generated from combined sex and/or multi-aged cohorts without proper confounding. A scoping literature review of PubMed, Web of Science, EMBASE, and
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Reflections on 30 years of publishing osteoarthritis research: Where we’ve been and where we’re going Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Michelle S. Yau, Stephanie R. Filbay, Joel A. Block, L. Stefan Lohmander
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miR-708–5p deficiency involves the degeneration of mandibular condylar chondrocytes via the TLR4/NF-κB pathway Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Lingfeng Xu, Yuejiao Zhang, Jia Yu, Wanqiu Huo, Jiali Xu, Hongxu Yang, Mian Zhang, Shibing Yu, Yaoping Wu, Meiqing Wang
Ageing and aberrant biomechanical stimulation are two major risk factors for osteoarthritis (OA). One of the main characteristics of aged cartilage is cellular senescence. One of the main characteristics of osteoarthritic joints is cartilage degeneration. The cells in the temporomandibular joint (TMJ) cartilage are zonally arranged. The deep zone cells are differentiated from the superficial zone cells
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Alterations in compositional and cellular properties of the subchondral bone are linked to cartilage degeneration in hip osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Julian Delsmann, Julian Eissele, Alexander Simon, Assil-Ramin Alimy, Simon von Kroge, Herbert Mushumba, Klaus Püschel, Björn Busse, Christian Ries, Michael Amling, Frank Timo Beil, Tim Rolvien
The subchondral bone is an emerging regulator of osteoarthritis (OA). However, knowledge of how specific subchondral alterations relate to cartilage degeneration remains incomplete. Femoral heads were obtained from 44 patients with primary OA during total hip arthroplasty and from 30 non-OA controls during autopsy. A multiscale assessment of the central subchondral bone region comprising histomorphometry
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Assessing the degree to which randomized control trials align with the core outcome set for osteoarthritis of knee and hip: A cross-sectional analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Trevon Jelinek, Alec Young, Garrett Jones, Kimberly Magana, Trevor Magee, Shaelyn Ward, Jay Modi, Kyle Fitzgerald, Griffin Hughes, Alicia Ito Ford, Matt Vassar
To assess the degree of core outcome set alignment and identify issues with alignment to the 2019 COS among clinical trial registrations focused on knee and/or hip osteoarthritis (OA). Our search was performed on registered knee and hip OA randomized controlled trials (RCTs) available on ClinicalTrials.gov and WHO International Clinical Trials Registry Platform. The screening process considered trials
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Importance of IL-6 trans-signaling and high autocrine IL-6 production in human osteoarthritic chondrocyte metabolism Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-16 Annett Eitner, Christian König, Felix C. Kohler, Gunther O. Hofmann, Britt Wildemann, Matthias Aurich, Hans-Georg Schaible
Neutralization of Interleukin (IL)-6-signaling by antibodies is considered a promising tool for the treatment of osteoarthritis (OA). To gain further insight into this potential treatment, this study investigated the effects of IL-6-signaling and IL-6 neutralization on chondrocyte metabolism and the release of IL-6-signaling-related mediators by human chondrocytes. Chondrocytes were collected from
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Progress in rehabilitation-related exercise for knee OA at OARSI over the past 30 years Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-13 Daniel K. White, Louise M. Thoma
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Obesity and body mass index: Past and future considerations in osteoarthritis research Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-12 Kristine Godziuk, Gillian A. Hawker
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties and limitations. These include an inability to discern fat and muscle mass, account for sex-differences in fat distribution, or identify adiposity-related health impairments. A focus on BMI in OA research
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Changing the narrative on osteoarthritis: A call for global action Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-12 Clare Jinks, Angie Botto-van Bemden, Samantha Bunzli, Jocelyn Bowden, Thorlene Egerton, Jillian Eyles, Nadine Foster, Emma L. Healey, John Maddison, Daniel O’Brien, Jonathan G. Quicke, Dieuwke Schiphof, Emma Parry, Martin J. Thomas, Melanie A. Holden, Change OA Narrative (COAN) Initiative, Kelli Allen, Opeyemi O Babatunde, Kim L Bennel, Alice Berry, Sita Bierma-Zeinstra, Leigh Callahan, Laura Campbell
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30 Years of MRI-based cartilage & bone morphometry in knee osteoarthritis: From correlation to clinical trials Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-06 Felix Eckstein, Anita E. Wluka, Wolfgang Wirth, Flavia Cicuttini
The first publication on morphometric analysis of articular cartilage using magnetic resonance imaging (MRI) in 1994 set the scene for a game change in osteoarthritis (OA) research. The current review highlights milestones in cartilage and bone morphometry, summarizing the rapid progress made in imaging, its application to understanding joint (patho-)physiology, and its use in interventional clinical
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Adoption of core outcome sets in osteoarthritis clinical trials: Still a long way to go Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-05 Toby O. Smith
Abstract not available
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Associations of inflammatory and metabolic biomarkers with incident erosive hand osteoarthritis in the osteoarthritis initiative cohort Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-03 Timothy E. McAlindon, Jennifer L. Hunnicutt, Mary B. Roberts, Ida K. Haugen, Lena F. Schaefer, Jeffrey B. Driban, Bing Lu, Jeffrey Duryea, Stacy E. Smith, Sarah L. Booth, Gayle A. Petty, Alexander Mathiessen, Li Zeng, Charles Eaton
Erosive hand osteoarthritis (eHOA) is a subtype of hand osteoarthritis (OA) that develops in finger joints with pre-existing OA and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes. This was a longitudinal nested case-cohort design among Osteoarthritis Initiative participants who had hand radiographs at
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Molecular pathogenesis of OA pain: Past, present, and future Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-18 Tonia L. Vincent, Rachel E. Miller
To provide a historical perspective and narrative review on research into the molecular pathogenesis of osteoarthritis pain. PubMed databases were searched for combinations of “osteoarthritis”, “pain” and “animal models” for papers that represented key phases in the history of osteoarthritis pain discovery research including epidemiology, pathology, imaging, preclinical modeling and clinical trials
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Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST) Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Michelle S. Yau, Paul C. Okoro, Ida K. Haugen, John A. Lynch, Michael C. Nevitt, Cora E. Lewis, James C. Torner, David T. Felson
Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA. We analyzed data from the Multicenter Osteoarthritis Study in a subset of 671 participants ages 45–69 years with no or mild radiographic knee OA. DNA methylation was assessed with the Illumina Infinium MethylationEPIC
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Anaphylatoxins and their corresponding receptors as potential drivers in cartilage calcification during osteoarthritis progression Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Leonie Ruths, Markus Huber-Lang, Gundula Schulze-Tanzil, Jana Riegger
The complement cascade as major fluid phase innate immune system is activated during progression of osteoarthritis (OA). Generated anaphylatoxins and the corresponding receptors C3aR and C5aR1 are associated with the calcification of blood vessels and involved in osteogenic differentiation. This study aims on elucidating whether complement activation products contribute to cartilage calcification of
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Looking back on 30+ years of the Johnston County Osteoarthritis Project while looking forward with the Johnston County Health Study: A narrative review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Yvonne M. Golightly, Jordan B. Renner, Charles G. Helmick, Joanne M. Jordan, Amanda E. Nelson
Over the last 30 years, knowledge of the epidemiology of osteoarthritis (OA) has dramatically advanced, and has been on the forefront of disseminating research findings from large OA cohort studies, including the Johnston County OA Project (JoCoOA). The JoCoOA is a population-based, prospective longitudinal cohort that began roughly 30 years ago with a key focus on understanding prevalence, incidence
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Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a Knowledge Mobilisation Toolkit Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Laura Swaithes, Zoe Paskins, Andrew Finney, Nicola Walsh, Magdalena Skrybant, Christian Mallen, Krysia Dziedzic
Implementing clinical guidelines for osteoarthritis (OA) in primary care is complex. Whilst international guidelines detail best practice for OA looks like, little is known about this is best implemented. Limited resources are available to guideline developers, practitioners, researchers, or the public to facilitate implementation. Set in the context of a larger research project which sought to understand
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Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-11 Chun-Wei Liang, Hsiao-Yi Cheng, Yu-Hao Lee, Chun-De Liao, Shih-Wei Huang
To investigate the efficacy and safety of collagen derivatives for osteoarthritis. PubMed, Embase, and Cochrane Library were searched till June 2023 for randomized controlled trials (RCTs) investigating collagen derivatives for treating osteoarthritis. Data were independently extracted by two authors. The risk of bias was assessed using the RoB 2 tool. A random-effects meta-analysis was performed within
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A perspective on the evolution of semi-quantitative MRI assessment of osteoarthritis: Past, present and future Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-10 Frank W. Roemer, Mohamed Jarraya, Daichi Hayashi, Michel D. Crema, Ida K. Haugen, David J. Hunter, Ali Guermazi
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The evolving landscape of gene therapy strategies for the treatment of osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-08 Matthew W. Grol PhD
Significant advances have been made in our understanding of osteoarthritis (OA) pathogenesis; however, no disease-modifying therapies have been identified. This review will summarize the gene therapy landscape, its initial successes for OA, and possible challenges using recent studies and examples of gene therapies in clinical trials. This narrative review has three major sections: 1) vector systems
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Mitonuclear epistasis involving TP63 and haplogroup Uk: Risk of rapid progression of knee OA in patients from the OAI Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-06 Alejandro Durán-Sotuela, Natividad Oreiro, Mercedes Fernández-Moreno, Jorge Vázquez-García, Sara Relaño-Fernández, Vanesa Balboa-Barreiro, Francisco J. Blanco, Ignacio Rego-Pérez
To investigate genetic interactions between mitochondrial deoxyribonucleic acid (mtDNA) haplogroups and nuclear single nucleotide polymorphisms (nSNPs) to analyze their impact on the development of the rapid progression of knee osteoarthritis (OA). A total of 1095 subjects from the Osteoarthritis Initiative, with a follow-up time of at least 48-months, were included. Appropriate statistical approaches
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Causal relationships between anthropometric traits, bone mineral density, osteoarthritis and spinal stenosis: a Mendelian randomization investigation Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-30 Maria K Sobczyk, Benjamin G Faber, Lorraine Southam, Monika Frysz, April Hartley, Eleftheria Zeggini, , Haotian Tang, Tom R Gaunt
Objective Spinal stenosis is a common condition among older individuals, with significant morbidity attached. Little is known about its risk factors but degenerative conditions, such as osteoarthritis (OA) have been identified for their mechanistic role. This study aims to explore causal relationships between anthropometric risk factors, osteoarthritis, and spinal stenosis using Mendelian randomization
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What is the rational for mesenchymal stromal cells based therapies in the management of hemophilic arthropathies? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-29 Alexandre Théron, Marie Maumus, Christine Biron-Andreani, Nicolas Sirvent, Christian Jorgensen, Danièle Noël
Hemophilia A and B are rare X-linked genetic bleeding disorders due to a complete or partial deficiency in the coagulation factors VIII or IX, respectively. The main treatment for hemophilia is prophylactic and based on coagulation factor replacement therapies. These treatments have significantly reduced bleedings and improved the patients’ quality of life. Nevertheless, repeated joint bleedings (hemarthroses)
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Is RANKL a potential molecular target in osteoarthritis? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-30 Dzenita Muratovic, Gerald J. Atkins, David M. Findlay
Osteoarthritis (OA) is a disease of joints, in which the bone under the articular cartilage undergoes increased remodelling activity. The question is whether a better understanding of the causes and mechanisms of bone remodelling can predict disease-modifying treatments. This review summarises the current understanding of the aetiology of OA, with an emphasis on events in the subchondral bone (SCB)
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Priming chondrocytes during expansion alters cell behavior and improves matrix production in 3D culture Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-30 Emily D. Lindberg, Tiffany Wu, Kristen L. Cotner, Amanda Glazer, Amir A. Jamali, Lydia L. Sohn, Tamara Alliston, Grace D. O’Connell
Cartilage tissue engineering strategies that use autologous chondrocytes require in vitro expansion of cells to obtain enough cells to produce functional engineered tissue. However, chondrocytes dedifferentiate during expansion culture, limiting their ability to produce chondrogenic tissue and their utility for cell-based cartilage repair strategies. The current study identified conditions that favor
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Inflammation in osteoarthritis: Our view on its presence and involvement in disease development over the years Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-23 Martijn H.J. van den Bosch, Arjen B. Blom, Peter M. van der Kraan
Inflammation, both locally in the joint and systemic, is nowadays considered among the mechanisms involved in osteoarthritis (OA). However, this concept has not always been generally accepted. In fact, for long OA has been described as a relatively simple degeneration of articular cartilage as the result of wear and tear only. In this narrative review, we present what our understanding of OA was at
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Relationships between diagnostic imaging of first carpometacarpal osteoarthritis and pain, functional status, and disease progression: A systematic review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-21 Dario F. Mazza, Pattira S. Boonsri, Aman Arora, Christopher O. Bayne, Robert M. Szabo, Abhijit J. Chaudhari, Robert D. Boutin
To systematically review the association of pain, function, and progression in first carpometacarpal (CMC) osteoarthritis (OA) with imaging biomarkers and radiography-based staging. Database searches in PubMed, Embase, and the Cochrane Library, along with citation searching were conducted in accordance with published guidance. Data on the association of imaging with pain, functional status, and disease
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A public health approach to osteoarthritis in the United States Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-21 Kirsten R. Ambrose, Katie F. Huffman, Erica L. Odom, Anika L. Foster, Nick Turkas, Leigh F. Callahan
Abstract not available
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Biomarkers have to make sense Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-19 André Struglics
Abstract not available
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Expanding from unilateral to bilateral: a robust deep learning-based approach for predicting radiographic osteoarthritis progression Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-17 Rui Yin, Hao Chen, Tianqi Tao, Kaibin Zhang, Guangxu Yang, Fajian Shi, Yiqiu Jiang, Jianchao Gui
Objective To develop and validate a deep learning model for predicting osteoarthritis (OA) progression based on bilateral knee joint views. Methods In this retrospective study, knee joints from bilateral posteroanterior knee radiographs of participants in the Osteoarthritis Initiative were analyzed. At baseline, participants were divided into testing set 1 and development set according to the different
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Let’s DAG it! But wait…which variables should we include in our graphical model? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-17 Daniel Cury Ribeiro
Abstract not available
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Mechanical Loading of Joint Modulates T Cells in Lymph Nodes to Regulate Osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-10 Tibra A. Wheeler, Adrien Y. Antoinette, Eshant Bhatia, Matthew J. Kim, Chiemezue N. Ijomanta, Ann Zhao, Marjolein C.H. van der Meulen, Ankur Singh
Objective The crosstalk of joint pathology with local lymph nodes in osteoarthritis (OA) is poorly understood. We characterized the change in T cells in lymph nodes following load-induced OA and established the association of the presence and migration of T cells to the onset and progression of OA. Methods We used an in vivo model of OA to induce mechanical load-induced joint damage. After cyclic tibial
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Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-05 Jiri Jäntti, Anisha Joenathan, Maria Fugazzola, Juuso Tuppurainen, Juuso T.J. Honkanen, Juha Töyräs, René van Weeren, Brian D. Snyder, Mark W. Grinstaff, Hanna Matikka, Janne T.A. Mäkelä
Objective Cationic tantalum oxide nanoparticles (Ta2O5-cNPs), as a newly introduced contrast agent for computed tomography (CT) of cartilage, offer quantitative evaluation of proteoglycan content and biomechanical properties. However, knowledge on the depth-wise impact of cartilage constituents on NP diffusion, particularly the influence of the collagen network, is lacking. In this study, we aim to
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Links between three chronic and age-related diseases, osteoarthritis, periodontitis, and osteoporosis, in a wild mammal (moose) population Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Sarah R. Hoy, John A. Vucetich, Leah M. Vucetich, Mary Hindelang, Janet L. Huebner, Virginia B. Kraus, Rolf O. Peterson
Objective Osteoarthritis, periodontitis and osteoporosis are chronic, age-related diseases which adversely impact millions of people worldwide. Because these diseases pose a major global public health challenge, there is an urgent need to better understand how these diseases are interrelated. Our objective was to document the age and sex-specific prevalence of each disease and assess interrelationships
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Constructing a Clinical Radiographic Knee Osteoarthritis Database Using Artificial Intelligence Tools with Limited Human Labor: A Proof of Principle Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-01 Anders Lenskjold, Mathias W Brejnebøl, Janus U Nybing, Martin H Rose, Henrik Gudbergsen, Anders Troelsen, Anne Moller, Henriette Raaschou, Mikael Boesen
Objective To create a scalable and feasible retrospective consecutive knee osteoarthritis (OA) radiographic database with limited human labor using commercial and custom-built artificial intelligence (AI) tools. Methods We applied four AI tools, two commercially available and two custom-built tools, to analyze six years of clinical consecutive knee radiographs from patients aged 35 to 79 at the University
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Osteoarthritis year in review 2023: Biomechanics Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Laura E. Diamond, Tamara Grant, Scott D. Uhlrich
Biomechanics plays a significant yet complex role in osteoarthritis (OA) onset and progression. Identifying alterations in biomechanical factors and their complex interactions is critical for gaining new insights into OA pathophysiology and identification of clearly defined and modifiable mechanical treatment targets. This review synthesized biomechanics studies from March 2022 to April 2023, from
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Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Muhammad Farooq Rai, Kelsey H. Collins, Annemarie Lang, Tristan Maerz, Jeroen Geurts, Cristina Ruiz-Romero, Ronald K. June, Yolande Ramos, Sarah J. Rice, Shabana Amanda Ali, Chiara Pastrello, Igor Jurisica, C. Thomas Appleton, Jason S. Rockel, Mohit Kapoor
Osteoarthritis (OA) is a complex disease involving contributions from both local joint tissues and systemic sources. Patient characteristics, encompassing sociodemographic and clinical variables, are intricately linked with OA rendering its understanding challenging. Technological advancements have allowed for a comprehensive analysis of transcripts, proteomes and metabolomes in OA tissues/fluids through
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Aging and the emerging role of cellular senescence in osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Brian O. Diekman, Richard F. Loeser
The correlation between age and incidence of osteoarthritis (OA) is well known but the causal mechanisms involved are not completely understood. This narrative review summarizes selected key findings from the past 30 years that have elucidated key aspects of the relationship between aging and OA. The peer-reviewed English language literature was searched on PubMed using keywords including senescence