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Appraisal of quality and analysis of the similarities and differences between osteoarthritis Clinical Practice Guideline recommendations: A systematic review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-05 Bimbi Gray, Alison Gibbs, Jocelyn L Bowden, Jillian P Eyles, Sandra Grace, Kim Bennell, Rinie Geenen, Sharon Kolasinski, Christian Barton, Philip G Conaghan, Timothy McAlindon, Olivier Bruyere, Quentin Géczy, David J Hunter
Clinical Practice Guidelines (CPGs) aim to support management of hip and knee osteoarthritis (OA), but recommendations are often conflicting and implementation is poor, contributing to evidence-to-practice gaps. This systematic review investigated the contextual and methodological factors contributing to conflicting recommendations for hip and knee OA. Our systematic review appraised CPGs for managing
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Hip contact forces can be predicted with a neural network using only synthesised key points and electromyography in people with hip osteoarthritis. Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Bradley M. Cornish, Claudio Pizzolato, David J. Saxby, Zhengliang Xia, Daniel Devaprakash, Laura E. Diamond
To develop and validate a neural network to estimate hip contact forces (HCF), and lower body kinematics and kinetics during walking in individuals with hip osteoarthritis (OA) using synthesised anatomical key points and electromyography. To assess the capability of the neural network to detect directional changes in HCF resulting from prescribed gait modifications. A calibrated electromyography-informed
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Modulation of early osteoarthritis by tibiofemoral re-alignment in sheep Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Jan Reinhard, Tamás Oláh, Matthias W. Laschke, Lars K.H. Goebel, Gertrud Schmitt, Susanne Speicher-Mentges, Michael D. Menger, Magali Cucchiarini, Dietrich Pape, Henning Madry
To investigate whether tibiofemoral alignment influences early knee osteoarthritis (OA). We hypothesized that varus overload exacerbates early degenerative osteochondral changes, and that valgus underload diminishes early OA. Normal, over- and underload were induced by altering alignment via high tibial osteotomy in adult sheep (n = 8 each). Simultaneously, OA was induced by partial medial anterior
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Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-01 Katherine M. Arnold, Samantha R. Weaver, Elizabeth L. Zars, Daniel J. Tschumperlin, Jennifer J. Westendorf
Phlpp1 inhibition is a potential therapeutic strategy for cartilage regeneration and prevention of post-traumatic osteoarthritis (PTOA). To understand how Phlpp1 loss affects cartilage structure, cartilage elastic modulus was measured with atomic force microscopy (AFM) in male and female mice after injury. Osteoarthritis was induced in male and female Wildtype (WT) and Phlpp1 mice by destabilization
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Evolution and advancements in genomics and epigenomics in OA research: How far we have come Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-28 Yolande Ramos, Sarah J. Rice, Shabana Amanda Ali, Chiara Pastrello, Igor Jurisica, Muhammad Farooq Rai, Kelsey H. Collins, Annemarie Lang, Tristan Maerz, Jeroen Geurts, Cristina Ruiz-Romero, Ronald K. June, C. Thomas Appleton, Jason S. Rockel, Mohit Kapoor
Osteoarthritis (OA) is the most prevalent musculoskeletal disease affecting articulating joint tissues, resulting in local and systemic changes that contribute to increased pain and reduced function. Diverse technological advancements have culminated in the advent of high throughput “omic” technologies, enabling identification of comprehensive changes in molecular mediators associated with the disease
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A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-24 Holly L. Stewart, Derek Gilbert, Darko Stefanovski, Zoe Garman, Michael B. Albro, Manish Bais, Mark W. Grinstaff, Brian D. Snyder, Thomas P. Schaer
The objective was to critically analyze the published literature accounting for sex differences and skeletal age (open vs. closed physis) in preclinical animal models of OA, including the disaggregation of data by sex and skeletal maturity when data is generated from combined sex and/or multi-aged cohorts without proper confounding. A scoping literature review of PubMed, Web of Science, EMBASE, and
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Reflections on 30 years of publishing osteoarthritis research: Where we’ve been and where we’re going Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Michelle S. Yau, Stephanie R. Filbay, Joel A. Block, L. Stefan Lohmander
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miR-708–5p deficiency involves the degeneration of mandibular condylar chondrocytes via the TLR4/NF-κB pathway Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Lingfeng Xu, Yuejiao Zhang, Jia Yu, Wanqiu Huo, Jiali Xu, Hongxu Yang, Mian Zhang, Shibing Yu, Yaoping Wu, Meiqing Wang
Ageing and aberrant biomechanical stimulation are two major risk factors for osteoarthritis (OA). One of the main characteristics of aged cartilage is cellular senescence. One of the main characteristics of osteoarthritic joints is cartilage degeneration. The cells in the temporomandibular joint (TMJ) cartilage are zonally arranged. The deep zone cells are differentiated from the superficial zone cells
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Alterations in compositional and cellular properties of the subchondral bone are linked to cartilage degeneration in hip osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Julian Delsmann, Julian Eissele, Alexander Simon, Assil-Ramin Alimy, Simon von Kroge, Herbert Mushumba, Klaus Püschel, Björn Busse, Christian Ries, Michael Amling, Frank Timo Beil, Tim Rolvien
The subchondral bone is an emerging regulator of osteoarthritis (OA). However, knowledge of how specific subchondral alterations relate to cartilage degeneration remains incomplete. Femoral heads were obtained from 44 patients with primary OA during total hip arthroplasty and from 30 non-OA controls during autopsy. A multiscale assessment of the central subchondral bone region comprising histomorphometry
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Assessing the degree to which randomized control trials align with the core outcome set for osteoarthritis of knee and hip: A cross-sectional analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Trevon Jelinek, Alec Young, Garrett Jones, Kimberly Magana, Trevor Magee, Shaelyn Ward, Jay Modi, Kyle Fitzgerald, Griffin Hughes, Alicia Ito Ford, Matt Vassar
To assess the degree of core outcome set alignment and identify issues with alignment to the 2019 COS among clinical trial registrations focused on knee and/or hip osteoarthritis (OA). Our search was performed on registered knee and hip OA randomized controlled trials (RCTs) available on ClinicalTrials.gov and WHO International Clinical Trials Registry Platform. The screening process considered trials
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Importance of IL-6 trans-signaling and high autocrine IL-6 production in human osteoarthritic chondrocyte metabolism Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-16 Annett Eitner, Christian König, Felix C. Kohler, Gunther O. Hofmann, Britt Wildemann, Matthias Aurich, Hans-Georg Schaible
Neutralization of Interleukin (IL)-6-signaling by antibodies is considered a promising tool for the treatment of osteoarthritis (OA). To gain further insight into this potential treatment, this study investigated the effects of IL-6-signaling and IL-6 neutralization on chondrocyte metabolism and the release of IL-6-signaling-releated mediators by human chondrocytes. Chondrocytes were collected from
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Progress in rehabilitation-related exercise for knee OA at OARSI over the past 30 years Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-13 Daniel K. White, Louise M. Thoma
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Obesity and body mass index: Past and future considerations in osteoarthritis research Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-12 Kristine Godziuk, Gillian A. Hawker
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties and limitations. These include an inability to discern fat and muscle mass, account for sex-differences in fat distribution, or identify adiposityrelated health impairments. A focus on BMI in OA research
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Changing the narrative on osteoarthritis: A call for global action Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-12 Clare Jinks, Angie Botto-van Bemden, Samantha Bunzli, Jocelyn Bowden, Thorlene Egerton, Jillian Eyles, Nadine Foster, Emma L. Healey, John Maddison, Daniel O’Brien, Jonathan G. Quicke, Dieuwke Schiphof, Emma Parry, Martin J. Thomas, Melanie A. Holden, Change OA Narrative (COAN) Initiative
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30 Years of MRI-based cartilage & bone morphometry in knee osteoarthritis: From correlation to clinical trials Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-06 Felix Eckstein, Anita E. Wluka, Wolfgang Wirth, Flavia Cicuttini
The first publication on morphometric analysis of articular cartilage using magnetic resonance imaging (MRI) in 1994 set the scene for a game change in osteoarthritis (OA) research. The current review highlights milestones in cartilage and bone morphometry, summarizing the rapid progress made in imaging, its application to understanding joint (patho-)physiology, and its use in interventional clinical
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Adoption of core outcome sets in osteoarthritis clinical trials: Still a long way to go Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-05 Toby O. Smith
Abstract not available
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Associations of inflammatory and metabolic biomarkers with incident erosive hand osteoarthritis in the osteoarthritis initiative cohort Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-03 Timothy E. McAlindon, Jennifer L. Hunnicutt, Mary B. Roberts, Ida K. Haugen, Lena F. Schaefer, Jeffrey B. Driban, Bing Lu, Jeffrey Duryea, Stacy E. Smith, Sarah L. Booth, Gayle A. Petty, Alexander Mathiessen, Li Zeng, Charles Eaton
Erosive hand osteoarthritis (eHOA) is a subtype of hand OA that develops in finger joints with pre-existing osteoarthritis and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes. This was a longitudinal nested case-cohort design among Osteoarthritis Initiative participants who had hand radiographs at baseline
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Molecular pathogenesis of OA pain: past, present, and future Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-18 Tonia L Vincent, Rachel E Miller
Objective To provide a historical perspective and narrative review on research into the molecular pathogenesis of osteoarthritis pain. Design PubMed databases were searched for combinations of “osteoarthritis”, “pain” and “animal models” for papers that represented key phases in the history of osteoarthritis pain discovery research including epidemiology, pathology, imaging, preclinical modelling and
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Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST) Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Michelle S. Yau, Paul C. Okoro, Ida K. Haugen, John A. Lynch, Michael C. Nevitt, Cora E. Lewis, James C. Torner, David T. Felson
Purpose Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA. Methods We analyzed data from the Multicenter Osteoarthritis Study (MOST) in a subset of 671 participants ages 45-69 years with no or mild radiographic knee OA. DNA methylation was assessed with the Illumina
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Anaphylatoxins and their corresponding receptors as potential drivers in cartilage calcification during osteoarthritis progression Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Leonie Ruths, Markus Huber-Lang, Gundula Schulze-Tanzil, Jana Riegger
Objective The complement cascade as major fluid phase innate immune system is activated during progression of osteoarthritis (OA). Generated anaphylatoxins and the corresponding receptors C3aR and C5aR1 are associated with the calcification of blood vessels and involved in osteogenic differentiation. This study aims on elucidating whether complement activation products contribute to cartilage calcification
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Looking Back on 30+ years of The Johnston County Osteoarthritis Project while Looking Forward with The Johnston County Health Study: a Narrative Review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Yvonne M. Golightly, Jordan B. Renner, Charles G. Helmick, Joanne M. Jordan, Amanda E. Nelson
Over the last 30 years, knowledge of the epidemiology of osteoarthritis (OA) has dramatically advanced, and Osteoarthritis and Cartilage has been on the forefront of disseminating research findings from large OA cohort studies, including the Johnston County OA Project (JoCoOA). The JoCoOA is a population-based, prospective longitudinal cohort that began roughly 30 years ago with a key focus on understanding
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Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a knowledge mobilisation toolkit Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-17 Laura Swaithes, Zoe Paskins, Andrew Finney, Nicola Walsh, Magdalena Skrybant, Christian Mallen, Krysia Dziedzic
Objective Implementing clinical guidelines for osteoarthritis in primary care is complex. Whilst international guidelines detail what best practice for osteoarthritis looks like, little is known about how this is best implemented. Limited resources are available to guideline developers, practitioners, researchers, or the public to facilitate implementation. Set in the context of a larger research project
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Efficacy and safety of collagen derivatives for osteoarthritis: a trial sequential meta-analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-11 Chun-Wei Liang, Hsiao-Yi Cheng, Yu-Hao Lee, Chun-De Liao, Shih-Wei Huang
Objective To investigate the efficacy and safety of collagen derivatives for osteoarthritis. Design PubMed, Embase, and Cochrane Library were searched till June 2023 for randomized controlled trials (RCTs) investigating collagen derivatives for treating osteoarthritis. Data were independently extracted by two authors. The risk of bias was assessed using the RoB 2 tool. A random-effects meta-analysis
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A perspective on the evolution of semi-quantitative MRI assessment of osteoarthritis: Past, present and future Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-10 Frank W. Roemer, Mohamed Jarraya, Daichi Hayashi, Michel D. Crema, Ida K. Haugen, David J. Hunter, Ali Guermazi
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The Evolving Landscape of Gene Therapy Strategies for The Treatment of Osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-08 Matthew W. Grol
Objectives Significant advances have been made in our understanding of osteoarthritis (OA) pathogenesis; however, no disease-modifying therapies have been identified. This review will summarize the gene therapy landscape, its initial successes for OA, and possible challenges using recent studies and examples of gene therapies in clinical trials. Design This narrative review has three major sections:
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Mitonuclear epistasis involving TP63 and haplogroup Uk: risk of rapid progression of knee OA in patients from the OAI Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-01-06 Alejandro Durán-Sotuela, Natividad Oreiro, Mercedes Fernández-Moreno, Jorge Vázquez-García, Sara Relaño-Fernández, Vanesa Balboa-Barreiro, Francisco J. Blanco, Ignacio Rego-Pérez
Objective To investigate genetic interactions between mtDNA haplogroups and nuclear single nucleotide polymorphisms (nSNPs) to analyze their impact on the development of the rapid progression of knee osteoarthritis (OA). Design A total of 1095 subjects from the Osteoarthritis Initiative (OAI), with a follow-up time of at least 48-months, were included. Appropriate statistical approaches were performed
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Is RANKL a potential molecular target in osteoarthritis? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-30 Dzenita Muratovic, Gerald J. Atkins, David M Findlay
Objective Osteoarthritis (OA) is a disease of joints, in which the bone under the articular cartilage undergoes increased remodelling activity. The question is whether a better understanding of the causes and mechanisms of bone remodelling can predict disease-modifying treatments. Design This review summarizes the current understanding of the aetiology of OA, with an emphasis on events in the subchondral
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Causal relationships between anthropometric traits, bone mineral density, osteoarthritis and spinal stenosis: a Mendelian randomization investigation Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-30 Maria K Sobczyk, Benjamin G Faber, Lorraine Southam, Monika Frysz, April Hartley, Eleftheria Zeggini, , Haotian Tang, Tom R Gaunt
Objective Spinal stenosis is a common condition among older individuals, with significant morbidity attached. Little is known about its risk factors but degenerative conditions, such as osteoarthritis (OA) have been identified for their mechanistic role. This study aims to explore causal relationships between anthropometric risk factors, osteoarthritis, and spinal stenosis using Mendelian randomization
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Priming Chondrocytes During Expansion Alters Cell Behavior and Improves Matrix Production in 3D Culture Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-30 Emily D. Lindberg, Tiffany Wu, Kristen L. Cotner, Amanda Glazer, Amir A. Jamali, Lydia L. Sohn, Tamara Alliston, Grace D. O’Connell
Objective Cartilage tissue engineering strategies that use autologous chondrocytes require in vitro expansion of cells to obtain enough cells to produce functional engineered tissue. However, chondrocytes dedifferentiate during expansion culture, limiting their ability to produce chondrogenic tissue and their utility for cell-based cartilage repair strategies. The current study identified conditions
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What is the rational for mesenchymal stromal cells based therapies in the management of hemophilic arthropathies? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-29 Alexandre Théron, Marie Maumus, Christine Biron-Andreani, Nicolas Sirvent, Christian Jorgensen, Danièle Noël
Hemophilia A and B are rare X-linked genetic bleeding disorders due to a complete or partial deficiency in the coagulation factors VIII or IX, respectively. The main treatment for hemophilia is prophylactic and based on coagulation factor replacement therapies. These treatments have significantly reduced bleedings and improved the patients’ quality of life. Nevertheless, repeated joint bleedings (hemarthroses)
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Inflammation in osteoarthritis: our view on its presence and involvement in disease development over the years Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-23 Martijn H.J. van den Bosch, Arjen B. Blom, Peter M. van der Kraan
Inflammation, both locally in the joint and systemic, is nowadays considered among the mechanisms involved in osteoarthritis (OA). However, this concept has not always been generally accepted. In fact, for long OA has been described as a relatively simple degeneration of articular cartilage as the result of wear and tear only. In this narrative review, we present what our understanding of OA was at
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Relationships Between Diagnostic Imaging of First Carpometacarpal Osteoarthritis and Pain, Functional Status, and Disease Progression: A Systematic Review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-21 Dario F. Mazza, Pattira S. Boonsri, Aman Arora, Christopher O. Bayne, Robert M. Szabo, Abhijit J. Chaudhari, Robert D. Boutin
Objective To systematically review the association of pain, function, and progression in first carpometacarpal osteoarthritis with imaging biomarkers and radiography-based staging. Design Database searches in PubMed, Embase, and the Cochrane Library, along with citation searching were conducted in accordance with published guidance. Data on the association of imaging with pain, functional status, and
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A public health approach to osteoarthritis in the United States Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-21 Kirsten R. Ambrose, Katie F. Huffman, Erica L. Odom, Anika L. Foster, Nick Turkas, Leigh F. Callahan
Abstract not available
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Biomarkers have to make sense Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-19 André Struglics
Abstract not available
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Expanding from unilateral to bilateral: a robust deep learning-based approach for predicting radiographic osteoarthritis progression Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-17 Rui Yin, Hao Chen, Tianqi Tao, Kaibin Zhang, Guangxu Yang, Fajian Shi, Yiqiu Jiang, Jianchao Gui
Objective To develop and validate a deep learning model for predicting osteoarthritis (OA) progression based on bilateral knee joint views. Methods In this retrospective study, knee joints from bilateral posteroanterior knee radiographs of participants in the Osteoarthritis Initiative were analyzed. At baseline, participants were divided into testing set 1 and development set according to the different
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Let’s DAG it! But wait…which variables should we include in our graphical model? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-17 Daniel Cury Ribeiro
Abstract not available
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Mechanical Loading of Joint Modulates T Cells in Lymph Nodes to Regulate Osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-10 Tibra A. Wheeler, Adrien Y. Antoinette, Eshant Bhatia, Matthew J. Kim, Chiemezue N. Ijomanta, Ann Zhao, Marjolein C.H. van der Meulen, Ankur Singh
Objective The crosstalk of joint pathology with local lymph nodes in osteoarthritis (OA) is poorly understood. We characterized the change in T cells in lymph nodes following load-induced OA and established the association of the presence and migration of T cells to the onset and progression of OA. Methods We used an in vivo model of OA to induce mechanical load-induced joint damage. After cyclic tibial
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Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-05 Jiri Jäntti, Anisha Joenathan, Maria Fugazzola, Juuso Tuppurainen, Juuso T.J. Honkanen, Juha Töyräs, René van Weeren, Brian D. Snyder, Mark W. Grinstaff, Hanna Matikka, Janne T.A. Mäkelä
Objective Cationic tantalum oxide nanoparticles (Ta2O5-cNPs), as a newly introduced contrast agent for computed tomography (CT) of cartilage, offer quantitative evaluation of proteoglycan content and biomechanical properties. However, knowledge on the depth-wise impact of cartilage constituents on NP diffusion, particularly the influence of the collagen network, is lacking. In this study, we aim to
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Links between three chronic and age-related diseases, osteoarthritis, periodontitis, and osteoporosis, in a wild mammal (moose) population Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Sarah R. Hoy, John A. Vucetich, Leah M. Vucetich, Mary Hindelang, Janet L. Huebner, Virginia B. Kraus, Rolf O. Peterson
Objective Osteoarthritis, periodontitis and osteoporosis are chronic, age-related diseases which adversely impact millions of people worldwide. Because these diseases pose a major global public health challenge, there is an urgent need to better understand how these diseases are interrelated. Our objective was to document the age and sex-specific prevalence of each disease and assess interrelationships
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Three Decades of Advancements in Osteoarthritis Research: Insights from Transcriptomic, Proteomic, and Metabolomic Studies Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Muhammad Farooq Rai, Kelsey H. Collins, Annemarie Lang, Tristan Maerz, Jeroen Geurts, Cristina Ruiz-Romero, Ronald K. June, Yolande Ramos, Sarah J. Rice, Shabana Amanda Ali, Chiara Pastrello, Igor Jurisica, C. Thomas Appleton, Jason S. Rockel, Mohit Kapoor
Objective Osteoarthritis (OA) is a complex disease involving contributions from both local joint tissues and systemic sources. Patient characteristics, encompassing sociodemographic and clinical variables, are intricately linked with OA rendering its understanding challenging. Technological advancements have allowed for a comprehensive analysis of transcripts, proteomes and metabolomes in OA tissues/fluids
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Aging and the Emerging Role of Cellular Senescence in Osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Brian O. Diekman, Richard F. Loeser
Objective The correlation between age and incidence of osteoarthritis (OA) is well known but the causal mechanisms involved are not completely understood. This narrative review summarizes selected key findings from the past 30 years that have elucidated key aspects of the relationship between aging and OA. Methods The peer-reviewed English language literature was searched on PubMed using key words
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Cost and outcomes of Hospital-based Usual cAre versus Tele-monitor self-directed Rehabilitation (HUATR) in patients with total knee arthroplasty: A randomized, controlled, non-inferiority trial Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Yong-Hao Pua, Seng-Jin Yeo, Ross Allan Clark, Bryan Yijia Tan, Terry Haines, Janet Prvu Bettger, Ee-Lin Woon, Hong Han Tan, John Wei-Ming Tan, Juanita Low, Eleanor Chew, Julian Thumboo
Objective To evaluate the clinical efficacy and cost-effectiveness of telemonitored self-directed rehabilitation (TR) compared with hospital-based rehabilitation (HBR) for patients with total knee arthroplasty (TKA). Design In this randomized, non-inferiority clinical trial, 114 patients with primary TKA who were able to walk independently preoperatively were randomized to receive HBR (n=58) or TR
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Constructing a Clinical Radiographic Knee Osteoarthritis Database Using Artificial Intelligence Tools with Limited Human Labor: A Proof of Principle Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-01 Anders Lenskjold, Mathias W Brejnebøl, Janus U Nybing, Martin H Rose, Henrik Gudbergsen, Anders Troelsen, Anne Moller, Henriette Raaschou, Mikael Boesen
Objective To create a scalable and feasible retrospective consecutive knee osteoarthritis (OA) radiographic database with limited human labor using commercial and custom-built artificial intelligence (AI) tools. Methods We applied four AI tools, two commercially available and two custom-built tools, to analyze six years of clinical consecutive knee radiographs from patients aged 35 to 79 at the University
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Osteoarthritis year in review 2023: Biomechanics Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-12-02 Laura E. Diamond, Tamara Grant, Scott D. Uhlrich
Biomechanics plays a significant yet complex role in osteoarthritis (OA) onset and progression. Identifying alterations in biomechanical factors and their complex interactions is critical for gaining new insights into OA pathophysiology and identification of clearly defined and modifiable mechanical treatment targets. This review synthesized biomechanics studies from March 2022 to April 2023, from
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Fatty acid binding protein 5 inhibition attenuates pronociceptive cytokine/chemokine expression and suppresses osteoarthritis pain: A comparative human and rat study Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-28 Chris Gordon, James Trainor, Rohan J. Shah, Keith Studholme, Alex Gelman, Faniya Doswell, Faisal Sadar, Allessio Giovannetti, Josh Gershenson, Ayesha Khan, James Nicholson, ZeYu Huang, Michael Spurgat, Shao-Jun Tang, Hehe Wang, Iwao Ojima, David Carlson, David E. Komatsu, Martin Kaczocha
Objective Osteoarthritis (OA) is often accompanied by debilitating pain that is refractory to available analgesics due in part to the complexity of signaling molecules that drive OA pain and our inability to target these in parallel. Fatty acid binding protein 5 (FABP5) is a lipid chaperone that regulates inflammatory pain; however, its contribution to OA pain has not been characterized. Design This
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Re-imagining rehabilitation after TKA: towards the provision of fit-for-purpose sustainable models of care and a redefinition of scope Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-28 JM Naylor, B Brady
Abstract not available
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How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-28 Iryoung Fan, Dhruv Govil, Matthew G King, Mark J Scholes, Adam I Semciw
Objective The aim of this systematic review and meta-analysis is to describe the effect of digitally delivered exercise on pain, physical function and quality of life for people with knee or hip osteoarthritis Methods Articles were eligible for inclusion if they were of a randomised control trial that evaluated the prescription of digitally delivered exercise (requiring the internet) in people with
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AI in osteoarthritis: illuminating the meandering path forward Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-25 Akshay S. Chaudhari
Abstract not available
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Osteoarthritis year in review 2023: Epidemiology & therapy Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-28 Anthony V. Perruccio, James J. Young, Jessica M. Wilfong, J. Denise Power, Mayilee Canizares, Elizabeth M. Badley
Objective To highlight some important findings from osteoarthritis (OA) epidemiology and therapy research undertaken over the past year. Methods Search of MEDLINE and EMBASE databases between April 1, 2022 to March 3, 2023 using “exp *Osteoarthritis/” as the preliminary search term. The search was limited to articles published in English and including human subjects. Final inclusions were based on
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Osteoarthritis pain phenotypes: How best to cut the cake? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-23 Stephanie L. Smith, David A. Walsh
Abstract not available
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Multiple Joint Osteoarthritis (MJOA): what’s in a name? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-19 Amanda E. Nelson
Objective To summarize the current state of the literature regarding multi-joint osteoarthritis (MJOA) and discuss important future directions. Design Narrative review of the author’s work and other key references on this topic with a focus on the Johnston County studies, definitions of MJOA and their impact, multi-site pain in OA, genetics and biomarkers in MJOA, and perspectives on future work. Results
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Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-19 Anna-Maria Liphardt, Elie-Tino Godonou, Maren Dreiner, Annegret Mündermann, Koray Tascilar, Nadja Djalal, Martina Heer, Georg Schett, Frank Zaucke, Anja Niehoff
Objective To investigate the effects of 21 days of bed rest immobilization (with and without exercise and nutrition interventions) on type II collagen biomarker concentrations in healthy individuals. Design Twelve healthy male participants (age 34.2 ± 8.3 years; body mass index 22.4 ± 1.7 kg/m²) were exposed to 6 days ambulatory baseline data collection (BDC), 21 days head-down-tilt bed rest (HDT,
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Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-19 Marie-Astrid Boutet, Alessandra Nerviani, Liliane Fossati-Jimack, Rebecca Hands-Greenwood, Manzoor Ahmed, Felice Rivellese, Costantino Pitzalis
Objectives Osteoarthritis (OA) is a debilitating and heterogeneous condition, characterized by various levels of articular cartilage degradation, osteophytes formation, and synovial inflammation. Multiple evidences suggest that synovitis may appear early in the disease development and correlates with disease severity and pain, therefore representing a relevant therapeutic target. In a typical synovitis-driven
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Osteoarthriris year in review 2023: genetics, genomics, and epigenetics Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-17 Amina Waheed, Muhammad Farooq Rai
Objective To elucidate the scientific advances made in the last 12 months within the realm of osteoarthritis genetics, genomics, and epigenetics. This review paper highlights major research publications that enhance our current understanding of the role of genetics, genomics, and epigenetics in osteoarthritis. Methods A systematic literature search was conducted on pubmed.ncbi.nlm.nih.gov on “March
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Three decades of osteoarthritis molecular genetics research: from early discussions to impressive breakthroughs Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-14 J. Loughlin
Abstract not available
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Genetic association between atopic disease and osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-10 Matthew C. Baker, William H. Robinson, Quinn Ostrom
Objectives To evaluate the association between genetically determined risk for atopic disease and osteoarthritis (OA). Methods We performed linkage disequilibrium (LD) score regression using 1000 Genomes Project European samples as a reference for patterns of genome-wide LD. Summary statistics for atopic disease traits were obtained from the UK Biobank. We generated a pairwise genetic correlation between
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Acknowledgement to Reviewers 2023 Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-10 D. Hunter, A.-M. Malfait
Abstract not available
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Causal relationships between pain, medical treatments, and knee osteoarthritis: a graphical causal model to guide analyses Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-07 Haadiya Cheema, Robert Brophy, Jamie Collins, Charles L. Cox, Ali Guermazi, Mahima Kumara, Bruce A. Levy, Lindsey MacFarlane, Lisa A. Mandl, Robert Marx, Faith Selzer, Kurt Spindler, Jeffrey N. Katz, Eleanor J Murray
Objective Randomized controlled trials (RCTs) are a gold standard for estimating benefits of clinical interventions, but their decision-making utility can be limited by relatively short follow-up time. Longer-term follow-up of RCT participants is essential to support treatment decisions. However, as time from randomization accrues, loss to follow-up and competing events can introduce biases and requires
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Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-05 Jiayi Zheng, Monika Frysz, Benjamin G. Faber, Huandong Lin, Raja Ebsim, Jieyu Ge, Yanling Yong, Fiona R. Saunders, Jennifer S. Gregory, Richard M. Aspden, Nicholas C. Harvey, Bing-Hua Jiang, Timothy Cootes, Claudia Lindner, Xin Gao, Sijia Wang, Jonathan H. Tobias
Objects Joint morphology is a risk factor for hip osteoarthritis (HOA) and could explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts. Methods Left hip iDXA scans were used to quantify rHOA, from a combination of
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Osteoarthritis year in review 2023: Biology Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-11-07 Anke J. Roelofs, Cosimo De Bari
Great progress continues to be made in our understanding of the multiple facets of osteoarthritis (OA) biology. Here, we review the major advances in this field and progress towards therapy development over the past year, highlighting a selection of relevant published literature from a PubMed search covering the year from the end of April 2022 to the end of April 2023. The selected articles have been