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Challenges with reinforcement learning model transportability for sepsis treatment in emergency care npj Digit. Med. (IF 12.4) Pub Date : 2025-02-06 Peter C. Nauka, Jason N. Kennedy, Emily B. Brant, Matthieu Komorowski, Romain Pirracchio, Derek C. Angus, Christopher W. Seymour
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CORE-MD clinical risk score for regulatory evaluation of artificial intelligence-based medical device software npj Digit. Med. (IF 12.4) Pub Date : 2025-02-06 Frank E. Rademakers, Elisabetta Biasin, Nico Bruining, Enrico G. Caiani, Rhodri H. Davies, Stephen H. Gilbert, Eric Kamenjasevic, Gearóid McGauran, Gearóid O’Connor, Jean-Baptiste Rouffet, Baptiste Vasey, Alan G. Fraser
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A multimodal multidomain multilingual medical foundation model for zero shot clinical diagnosis npj Digit. Med. (IF 12.4) Pub Date : 2025-02-06 Fenglin Liu, Zheng Li, Qingyu Yin, Jinfa Huang, Jiebo Luo, Anshul Thakur, Kim Branson, Patrick Schwab, Bing Yin, Xian Wu, Yefeng Zheng, David A. Clifton
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Predicting appropriateness of antibiotic treatment among ICU patients with hospital-acquired infection npj Digit. Med. (IF 12.4) Pub Date : 2025-02-06 Ella Goldschmidt, Ella Rannon, Daniel Bernstein, Asaf Wasserman, Michael Roimi, Anat Shrot, Dan Coster, Ron Shamir
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Real world federated learning with a knowledge distilled transformer for cardiac CT imaging npj Digit. Med. (IF 12.4) Pub Date : 2025-02-06 Malte Tölle, Philipp Garthe, Clemens Scherer, Jan Moritz Seliger, Andreas Leha, Nina Krüger, Stefan Simm, Simon Martin, Sebastian Eble, Halvar Kelm, Moritz Bednorz, Florian André, Peter Bannas, Gerhard Diller, Norbert Frey, Stefan Groß, Anja Hennemuth, Lars Kaderali, Alexander Meyer, Eike Nagel, Stefan Orwat, Moritz Seiffert, Tim Friede, Tim Seidler, Sandy Engelhardt
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Real world data on digital remote refraction in a healthy population of 14,680 eyes npj Digit. Med. (IF 12.4) Pub Date : 2025-02-06 Casper van der Zee, Heshow Jamal, Marc Muijzer, Laurence Frank, Gerko Vink, Robert Wisse
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An institutional framework to support ethical fair and equitable artificial intelligence augmented care npj Digit. Med. (IF 12.4) Pub Date : 2025-02-05 Steven Dykstra, Matthew MacDonald, Rhys Beaudry, Dina Labib, Melanie King, Yuanchao Feng, Jacqueline Flewitt, Jeff Bakal, Bing Lee, Stafford Dean, Marina Gavrilova, Paul W. M. Fedak, James A. White
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Multiple large language models versus experienced physicians in diagnosing challenging cases with gastrointestinal symptoms npj Digit. Med. (IF 12.4) Pub Date : 2025-02-05 Xintian Yang, Tongxin Li, Han Wang, Rongchun Zhang, Zhi Ni, Na Liu, Huihong Zhai, Jianghai Zhao, Fandong Meng, Zhongyin Zhou, Shanhong Tang, Limei Wang, Xiangping Wang, Hui Luo, Gui Ren, Linhui Zhang, Xiaoyu Kang, Jun Wang, Ning Bo, Xiaoning Yang, Weijie Xue, Xiaoyin Zhang, Ning Chen, Rui Guo, Baiwen Li, Yajun Li, Yaling Liu, Tiantian Zhang, Shuhui Liang, Yong Lv, Yongzhan Nie, Daiming Fan, Lina Zhao
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Assessment of priorities, quality, and inclusivity of digital therapeutics trials in China npj Digit. Med. (IF 12.4) Pub Date : 2025-02-04 Ziming Wang, Xinxin Xia, Weijia Lu, Yuguo Ye, Jin Xu
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Application of multimodal large language models for safety indicator calculation and contraindication prediction in laser vision correction npj Digit. Med. (IF 12.4) Pub Date : 2025-02-03 Joon Yul Choi, Doo Eun Kim, Sung Jin Kim, Hannuy Choi, Tae Keun Yoo
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The early warning paradox npj Digit. Med. (IF 12.4) Pub Date : 2025-02-03 Hugh Logan Ellis, Edward Palmer, James T. Teo, Martin Whyte, Kenneth Rockwood, Zina Ibrahim
Machine learning models in healthcare aim to predict critical outcomes but often overlook existing Early Warning Systems’ impact. Using data from King’s College Hospital, we demonstrate how current evaluation methods can lead to paradoxical results. We discuss challenges in developing ML models from retrospective data and propose a novel approach focused on identifying when patients enter a ‘risk state’
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AI prediction model for endovascular treatment of vertebrobasilar occlusion with atrial fibrillation npj Digit. Med. (IF 12.4) Pub Date : 2025-02-02 Zhi-Xin Huang, Andrea M. Alexandre, Alessandro Pedicelli, Xuying He, Quanlong Hong, Yongkun Li, Ping Chen, Qiankun Cai, Aldobrando Broccolini, Luca Scarcia, Serena Abruzzese, Carlo Cirelli, Mauro Bergui, Andrea Romi, Erwah Kalsoum, Giulia Frauenfelder, Grzegorz Meder, Simona Scalise, Maria Porzia Ganimede, Luigi Bellini, Bruno Del Sette, Francesco Arba, Susanna Sammali, Andrea Salcuni, Sergio Lucio
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3D convolutional deep learning for nonlinear estimation of body composition from whole body morphology npj Digit. Med. (IF 12.4) Pub Date : 2025-02-02 Isaac Y. Tian, Jason Liu, Michael C. Wong, Nisa N. Kelly, Yong E. Liu, Andrea K. Garber, Steven B. Heymsfield, Brian Curless, John A. Shepherd
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Evaluation and practical application of prompt-driven ChatGPTs for EMR generation npj Digit. Med. (IF 12.4) Pub Date : 2025-02-02 Hanlin Ding, Wenjie Xia, Yujia Zhou, Lei Wei, Yipeng Feng, Zi Wang, Xuming Song, Rutao Li, Qixing Mao, Bing Chen, Hui Wang, Xing Huang, Bin Zhu, Dongyu Jiang, Jingyu Sun, Gaochao Dong, Feng Jiang
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Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers npj Digit. Med. (IF 12.4) Pub Date : 2025-02-01 Julia C. Spinelli, Brandon J. Suleski, Donald E. Wright, Joseph L. Grow, Gabriel R. Fagans, Maura J. Buckley, Da Som Yang, Kaitao Yang, Steven M. Beil, Jessica C. Wallace, Thomas S. DiZoglio, Jeffrey B. Model, Shirley Love, David E. Macintosh, Alan P. Scarth, Matthew T. Marrapode, Corinna Serviente, Raudel Avila, Barrak K. Alahmad, Michael A. Busa, John A. Wright, Weihua Li, Douglas J. Casa, John A
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Language models for data extraction and risk of bias assessment in complementary medicine npj Digit. Med. (IF 12.4) Pub Date : 2025-01-31 Honghao Lai, Jiayi Liu, Chunyang Bai, Hui Liu, Bei Pan, Xufei Luo, Liangying Hou, Weilong Zhao, Danni Xia, Jinhui Tian, Yaolong Chen, Lu Zhang, Janne Estill, Jie Liu, Xing Liao, Nannan Shi, Xin Sun, Hongcai Shang, Zhaoxiang Bian, Kehu Yang, Luqi Huang, Long Ge
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Convergence of evolving artificial intelligence and machine learning techniques in precision oncology npj Digit. Med. (IF 12.4) Pub Date : 2025-01-31 Elena Fountzilas, Tillman Pearce, Mehmet A. Baysal, Abhijit Chakraborty, Apostolia M. Tsimberidou
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Digital twin driven electrode optimization for wearable bladder monitoring via bioimpedance npj Digit. Med. (IF 12.4) Pub Date : 2025-01-30 H. Trask Crane, John A. Berkebile, Samer Mabrouk, Nicholas Riccardelli, Omer T. Inan
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Telemedicine expands cardiovascular care in China – lessons for health equity in the United States npj Digit. Med. (IF 12.4) Pub Date : 2025-01-30 Elizabeth J. Enichen, Kimia Heydari, Ben Li, Joseph C. Kvedar
Liu et al.’s recent study reveals that telemedicine expanded access to cardiovascular care in China, enabling patients in poorer areas of the country to access care in cities with more resources. While these findings may support the global expansion of telemedicine, implementation often proves challenging. This article examines the potential and limitations of adopting similar telemedicine efforts
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A machine learning decision support tool optimizes WGS utilization in a neonatal intensive care unit npj Digit. Med. (IF 12.4) Pub Date : 2025-01-30 Edwin F. Juarez, Bennet Peterson, Erica Sanford Kobayashi, Sheldon Gilmer, Laura E. Tobin, Brandan Schultz, Jerica Lenberg, Jeanne Carroll, Shiyu Bai-Tong, Nathaly M. Sweeney, Curtis Beebe, Lawrence Stewart, Lauren Olsen, Julie Reinke, Elizabeth A. Kiernan, Rebecca Reimers, Kristen Wigby, Chris Tackaberry, Mark Yandell, Charlotte Hobbs, Matthew N. Bainbridge
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Whole slide image based deep learning refines prognosis and therapeutic response evaluation in lung adenocarcinoma npj Digit. Med. (IF 12.4) Pub Date : 2025-01-29 Tao Chen, Jialiang Wen, Xinchen Shen, Jiaqi Shen, Jiajun Deng, Mengmeng Zhao, Long Xu, Chunyan Wu, Bentong Yu, Minglei Yang, Minjie Ma, Junqi Wu, Yunlang She, Yifan Zhong, Likun Hou, Yanrui Jin, Chang Chen
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A phenotype-based AI pipeline outperforms human experts in differentially diagnosing rare diseases using EHRs npj Digit. Med. (IF 12.4) Pub Date : 2025-01-28 Xiaohao Mao, Yu Huang, Ye Jin, Lun Wang, Xuanzhong Chen, Honghong Liu, Xinglin Yang, Haopeng Xu, Xiaodong Luan, Ying Xiao, Siqin Feng, Jiahao Zhu, Xuegong Zhang, Rui Jiang, Shuyang Zhang, Ting Chen
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The use of large language models in detecting Chinese ultrasound report errors npj Digit. Med. (IF 12.4) Pub Date : 2025-01-28 Yuqi Yan, Kai Wang, Bojian Feng, Jincao Yao, Tian Jiang, Zhiyan Jin, Yin Zheng, Yahan Zhou, Chen Chen, Lin Sui, Xiayi Chen, Yanhong Du, Jie Yang, Qianmeng Pan, Lingyan Zhou, Vicky Yang Wang, Ping Liang, Dong Xu
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Dual modality feature fused neural network integrating binding site information for drug target affinity prediction npj Digit. Med. (IF 12.4) Pub Date : 2025-01-28 Haohuai He, Guanxing Chen, Zhenchao Tang, Calvin Yu-Chian Chen
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Machine learning meta-analysis identifies individual characteristics moderating cognitive intervention efficacy for anxiety and depression symptoms npj Digit. Med. (IF 12.4) Pub Date : 2025-01-28 Thalia Richter, Reut Shani, Shachaf Tal, Nazanin Derakshan, Noga Cohen, Philip M. Enock, Richard J. McNally, Nilly Mor, Shimrit Daches, Alishia D. Williams, Jenny Yiend, Per Carlbring, Jennie M. Kuckertz, Wenhui Yang, Andrea Reinecke, Christopher G. Beevers, Brian E. Bunnell, Ernst H. W. Koster, Sigal Zilcha-Mano, Hadas Okon-Singer
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Multimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses npj Digit. Med. (IF 12.4) Pub Date : 2025-01-27 Ruiqi Ma, Qian Cheng, Jing Yao, Zhiyu Peng, Mingxu Yan, Jie Lu, Jingjing Liao, Lejin Tian, Wenjun Shu, Yunqiu Zhang, Jinghan Wang, Pengfei Jiang, Weiyi Xia, Xiaofeng Li, Lu Gan, Yue Zhao, Jiang Zhu, Bing Qin, Qin Jiang, Xiawei Wang, Xintong Lin, Haifeng Chen, Weifang Zhu, Dehui Xiang, Baoqing Nie, Jingtao Wang, Jie Guo, Kang Xue, Hongguang Cui, Jinwei Cheng, Xiangjia Zhu, Jiaxu Hong, Fei Shi, Rui Zhang
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Towards evaluating and building versatile large language models for medicine npj Digit. Med. (IF 12.4) Pub Date : 2025-01-27 Chaoyi Wu, Pengcheng Qiu, Jinxin Liu, Hongfei Gu, Na Li, Ya Zhang, Yanfeng Wang, Weidi Xie
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Extensive benchmarking of a method that estimates external model performance from limited statistical characteristics npj Digit. Med. (IF 12.4) Pub Date : 2025-01-27 Tal El-Hay, Jenna M. Reps, Chen Yanover
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A systematic review of portable technologies for the early assessment of motor development in infants npj Digit. Med. (IF 12.4) Pub Date : 2025-01-27 Weiyang Deng, Megan K. O’Brien, Rachel A. Andersen, Richa Rai, Erin Jones, Arun Jayaraman
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AI driven decision support reduces antibiotic mismatches and inappropriate use in outpatient urinary tract infections npj Digit. Med. (IF 12.4) Pub Date : 2025-01-27 Shirley Shapiro Ben David, Roni Romano, Daniella Rahamim-Cohen, Joseph Azuri, Shira Greenfeld, Ben Gedassi, Uri Lerner
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A systematic review of passive data for remote monitoring in psychosis and schizophrenia npj Digit. Med. (IF 12.4) Pub Date : 2025-01-27 Siân Bladon, Emily Eisner, Sandra Bucci, Anuoluwapo Oluwatayo, Glen P. Martin, Matthew Sperrin, John Ainsworth, Sophie Faulkner
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A scoping review of privacy and utility metrics in medical synthetic data npj Digit. Med. (IF 12.4) Pub Date : 2025-01-27 Bayrem Kaabachi, Jérémie Despraz, Thierry Meurers, Karen Otte, Mehmed Halilovic, Bogdan Kulynych, Fabian Prasser, Jean Louis Raisaro
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Machine learning approach for noninvasive intracranial pressure estimation using pulsatile cranial expansion waveforms npj Digit. Med. (IF 12.4) Pub Date : 2025-01-26 Gustavo Frigieri, Sérgio Brasil, Danilo Cardim, Marek Czosnyka, Matheus Ferreira, Wellingson S. Paiva, Xiao Hu
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A multicenter study of neurofibromatosis type 1 utilizing deep learning for whole body tumor identification npj Digit. Med. (IF 12.4) Pub Date : 2025-01-26 Cheng-Jiang Wei, Yan Tang, Yang-Bai Sun, Tie-Long Yang, Cheng Yan, Hui Liu, Jun Liu, Jing-Ning Huang, Ming-Han Wang, Zhen-Wei Yao, Ji-Long Yang, Zhi-Chao Wang, Qing-Feng Li
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Explainable vision transformer for automatic visual sleep staging on multimodal PSG signals npj Digit. Med. (IF 12.4) Pub Date : 2025-01-25 Hyojin Lee, You Rim Choi, Hyun Kyung Lee, Jaemin Jeong, Joopyo Hong, Hyun-Woo Shin, Hyung-Sin Kim
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Transforming diagnosis through artificial intelligence npj Digit. Med. (IF 12.4) Pub Date : 2025-01-24 Luciana D’Adderio, David W. Bates
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Association between exposure to particulate matter and heart rate variability in vulnerable and susceptible individuals npj Digit. Med. (IF 12.4) Pub Date : 2025-01-24 Yong Whi Jeong, Hayon Michelle Choi, Youhyun Park, Yongjin Lee, Ji Ye Jung, Dae Ryong Kang
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V3+ extends the V3 framework to ensure user-centricity and scalability of sensor-based digital health technologies npj Digit. Med. (IF 12.4) Pub Date : 2025-01-24 Jessie P. Bakker, Roland Barge, Jacob Centra, Bryan Cobb, Chas Cota, Christine C. Guo, Bert Hartog, Nathalie Horowicz-Mehler, Elena S. Izmailova, Nikolay V. Manyakov, Samantha McClenahan, Stéphane Motola, Smit Patel, Oana Paun, Marian Schoone, Emre Sezgin, Thomas Switzer, Animesh Tandon, Willem van den Brink, Srinivasan Vairavan, Benjamin Vandendriessche, Bernard Vrijens, Jennifer C. Goldsack
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A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging npj Digit. Med. (IF 12.4) Pub Date : 2025-01-24 Zheyi Dong, Xiaofei Wang, Sai Pan, Taohan Weng, Xiaoniao Chen, Shuangshuang Jiang, Ying Li, Zonghua Wang, Xueying Cao, Qian Wang, Pu Chen, Lai Jiang, Guangyan Cai, Li Zhang, Yong Wang, Jinkui Yang, Yani He, Hongli Lin, Jie Wu, Li Tang, Jianhui Zhou, Shengxi Li, Zhaohui Li, Yibing Fu, Xinyue Yu, Yanqiu Geng, Yingjie Zhang, Liqiang Wang, Mai Xu, Xiangmei Chen
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Machine learning based quantitative pain assessment for the perioperative period npj Digit. Med. (IF 12.4) Pub Date : 2025-01-24 Gayeon Ryu, Jae Moon Choi, Hyeon Seok Seok, Jaehyung Lee, Eun-Kyung Lee, Hangsik Shin, Byung-Moon Choi
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Preserving information while respecting privacy through an information theoretic framework for synthetic health data generation npj Digit. Med. (IF 12.4) Pub Date : 2025-01-23 Nadir Sella, Florent Guinot, Nikita Lagrange, Laurent-Philippe Albou, Jonathan Desponds, Hervé Isambert
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Challenges and recommendations for enhancing digital data protection in Indian Medical Research and Healthcare Sector npj Digit. Med. (IF 12.4) Pub Date : 2025-01-22 Anubhuti Sood, Deepika Mishra, Varun Surya, Harpreet Singh, Rajesh Sundaresan, Debnath Pal, Raghu Dharmaraju, Rohit Satish, Shashwat Mishra, Nishant A. Chavan, Soham Mondal, Pavan Duggal, Venkateswaran K. Iyer
The Digital Personal Data Protection Act (DPDPA), 2023 of India provides a regulatory framework for use and security of personal digital data. However, instances, wherein the patients consult the clinicians via digital means of communication: the implications of DPDPA, 2023 for the medical personnel remain unclear. This paper critically discusses the gray areas encountered in the Indian medical ecosystem
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Impact of visual presentation of atherosclerotic carotid plaque on cardiovascular risk profile using mHealth technologies npj Digit. Med. (IF 12.4) Pub Date : 2025-01-22 Greta Ullrich, Alexander Bäuerle, Lisa Maria Jahre, Katrin Paldán, Jana Rosemeyer, Chiara Kalaitzidis, Christos Rammos, Martin Teufel, Tienush Rassaf, Julia Lortz
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Equitable artificial intelligence for glaucoma screening with fair identity normalization npj Digit. Med. (IF 12.4) Pub Date : 2025-01-20 Min Shi, Yan Luo, Yu Tian, Lucy Q. Shen, Nazlee Zebardast, Mohammad Eslami, Saber Kazeminasab, Michael V. Boland, David S. Friedman, Louis R. Pasquale, Mengyu Wang
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Computational frameworks transform antagonism to synergy in optimizing combination therapies npj Digit. Med. (IF 12.4) Pub Date : 2025-01-19 Jinghong Chen, Anqi Lin, Aimin Jiang, Chang Qi, Zaoqu Liu, Quan Cheng, Shuofeng Yuan, Peng Luo
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Clinical entity augmented retrieval for clinical information extraction npj Digit. Med. (IF 12.4) Pub Date : 2025-01-19 Ivan Lopez, Akshay Swaminathan, Karthik Vedula, Sanjana Narayanan, Fateme Nateghi Haredasht, Stephen P. Ma, April S. Liang, Steven Tate, Manoj Maddali, Robert Joseph Gallo, Nigam H. Shah, Jonathan H. Chen
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Advances in the estimation of body fat percentage using an artificial intelligence 2D-photo method npj Digit. Med. (IF 12.4) Pub Date : 2025-01-18 Tathiany J. Ferreira, Igor C. Salvador, Carolina R. Pessanha, Renata R. M. da Silva, Aline D. Pereira, Maria A. Horst, Denise P. Carvalho, Josely C. Koury, Anna P. T. R. Pierucci
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A pathway from fragmentation to interoperability through standards-based enterprise architecture to enhance patient safety npj Digit. Med. (IF 12.4) Pub Date : 2025-01-18 Zoie Shui-Yee Wong, Yang Gong, Shin Ushiro
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Preventing unrestricted and unmonitored AI experimentation in healthcare through transparency and accountability npj Digit. Med. (IF 12.4) Pub Date : 2025-01-18 Donnella S. Comeau, Danielle S. Bitterman, Leo Anthony Celi
The integration of large language models (LLMs) into electronic health records offers potential benefits but raises significant ethical, legal, and operational concerns, including unconsented data use, lack of governance, and AI-related malpractice accountability. Sycophancy, feedback loop bias, and data reuse risk amplifying errors without proper oversight. To safeguard patients, especially the vulnerable
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Survey and perspective on verification, validation, and uncertainty quantification of digital twins for precision medicine npj Digit. Med. (IF 12.4) Pub Date : 2025-01-17 Kaan Sel, Andrea Hawkins-Daarud, Anirban Chaudhuri, Deen Osman, Ahmad Bahai, David Paydarfar, Karen Willcox, Caroline Chung, Roozbeh Jafari
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Fusing multispectral information for retinal layer segmentation npj Digit. Med. (IF 12.4) Pub Date : 2025-01-17 Xiang He, Fuwang Wu, Kaixuan Hu, Lizhen Cui, Weiye Song, Yi Wan
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Modelling the impact of environmental and social determinants on mental health using generative agents npj Digit. Med. (IF 12.4) Pub Date : 2025-01-17 Joseph Kambeitz, Andreas Meyer-Lindenberg
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A scoping review of robustness concepts for machine learning in healthcare npj Digit. Med. (IF 12.4) Pub Date : 2025-01-17 Alan Balendran, Céline Beji, Florie Bouvier, Ottavio Khalifa, Theodoros Evgeniou, Philippe Ravaud, Raphaël Porcher
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Challenges and opportunities for digital twins in precision medicine from a complex systems perspective npj Digit. Med. (IF 12.4) Pub Date : 2025-01-17 Manlio De Domenico, Luca Allegri, Guido Caldarelli, Valeria d’Andrea, Barbara Di Camillo, Luis M. Rocha, Jordan Rozum, Riccardo Sbarbati, Francesco Zambelli
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Digital humanistic program to manage premature frailty in young breast cancer survivors with gender perspective npj Digit. Med. (IF 12.4) Pub Date : 2025-01-16 Yun Hu, Joshua Wiley, Lulu Jiang, Xiyi Wang, Ran Yi, Jiehui Xu, Yanyan Liu, Aozhou Weng, Futai Zou, Eun-Ok Im
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Privacy preserving strategies for electronic health records in the era of large language models npj Digit. Med. (IF 12.4) Pub Date : 2025-01-16 Jitendra Jonnagaddala, Zoie Shui-Yee Wong
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A systematic review of machine learning applications in predicting opioid associated adverse events npj Digit. Med. (IF 12.4) Pub Date : 2025-01-16 Carlos R. Ramírez Medina, Jose Benitez-Aurioles, David A. Jenkins, Meghna Jani
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Improving authenticity and provenance in digital biomarkers: the case for digital watermarking npj Digit. Med. (IF 12.4) Pub Date : 2025-01-15 Arjun Mahajan, Dylan Powell
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A policy framework for leveraging generative AI to address enduring challenges in clinical trials npj Digit. Med. (IF 12.4) Pub Date : 2025-01-15 Johnathon Edward Liddicoat, Gabriela Lenarczyk, Mateo Aboy, Timo Minssen, Sebastian Porsdam Mann
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Digital twin assisted surgery, concept, opportunities, and challenges npj Digit. Med. (IF 12.4) Pub Date : 2025-01-15 Lisa Asciak, Justicia Kyeremeh, Xichun Luo, Asimina Kazakidi, Patricia Connolly, Frederic Picard, Kevin O’Neill, Sotirios A. Tsaftaris, Grant D. Stewart, Wenmiao Shu