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PROSPECT methodology for developing procedure-specific pain management recommendations: an update Anaesthesia (IF 10.7) Pub Date : 2023-09-26 G. P. Joshi, E. Albrecht, M. Van de Velde, H. Kehlet, D. N. Lobo
The procedure-specific postoperative pain management (PROSPECT) working group develops evidence-based pain management recommendations. PROSPECT methodology is unique and rigorous. However, several limitations were recognised that needed to be addressed, and several new factors were identified that improved PROSPECT methodology. The aim of this article is to present updated PROSPECT methodology for
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Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study. Pain (IF 7.4) Pub Date : 2023-09-27 Joyce T Da Silva, Luis G Hernandez-Rojas, Hayelom K Mekonen, Shelby Hanson, Ohannes Melemedjian, Alison J Scott, Robert K Ernst, David A Seminowicz, Richard J Traub
Temporomandibular disorder (TMD) and irritable bowel syndrome (IBS) are 2 chronic overlapping pain conditions (COPCs) that present with significant comorbidity. Both conditions are more prevalent in women and are exacerbated by stress. While peripheral mechanisms might contribute to pain hypersensitivity for each individual condition, mechanisms underlying the comorbidity are poorly understood, complicating
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Antihyperalgesic properties of gut microbiota: Parabacteroides distasonis as a new probiotic strategy to alleviate chronic abdominal pain. Pain (IF 7.4) Pub Date : 2023-09-27 Sandie Gervason, Mathieu Meleine, Stéphane Lolignier, Maëva Meynier, Valentine Daugey, Aurélien Birer, Youssef Aissouni, Jean-Yves Berthon, Denis Ardid, Edith Filaire, Frédéric Antonio Carvalho
The potential role of gut microbiota in pain modulation is arousing an emerging interest since recent years. This study investigated neuromodulatory properties of gut microbiota to identify next-generation probiotics to propose alternative therapies for visceral pain management. Neuromodulation ability of 10 bacterial strains isolated from a healthy donor was assessed both on ND7/23 immortalized cell
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Comparative efficacy and safety of non-neuraxial analgesic techniques for midline laparotomy: a systematic review and frequentist network meta-analysis of randomised controlled trials Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-26 Garrett Barry, Herman Sehmbi, Susanne Retter, Jonathan G. Bailey, Rose Tablante, Vishal Uppal
Background Fascial plane blocks provide effective analgesia after midline laparotomy; however, the most efficacious technique has not been determined. We conducted a systematic review and network meta-analysis of randomised controlled trials to synthesise the evidence with respect to pain, opioid consumption, and adverse events. Methods We searched Ovid MEDLINE, Embase, Cochrane Central, and Scopus
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Clinical impact of fascial plane blocks: defining the research agenda Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-26 Xin Huang, Yan Zeng, Bhushan Sandeep, Jing Yang
Abstract not available
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Effects of altering harmonic structure on the recognition of simulated auditory arterial pressure alarms Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-26 Molly A. Bingham, Mabel L. Cummins, Anqy Tong, Palmer Purcell, Ayush Sangari, Aditya Sood, Joseph J. Schlesinger
Abstract not available
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Neuromodulation Techniques for the Spine, Alaa Abd-Elsayed (editor (2023), Published by Elsevier. 235 pp. Price $149.99. ISBN: 978-0-32-387584-4 Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-26 Philippe Rigoard
Abstract not available
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Volatile anaesthetic toxicity in the genetic mitochondrial disease Leigh syndrome Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-26 Kira A. Spencer, Michael Mulholland, John Snell, Miranda Howe, Katerina James, Allison R. Hanaford, Philip G. Morgan, Margaret Sedensky, Simon C. Johnson
Background Volatile anaesthetics are widely used in human medicine. Although generally safe, hypersensitivity and toxicity can occur in rare cases, such as in certain genetic disorders. Anaesthesia hypersensitivity is well-documented in a subset of mitochondrial diseases, but whether volatile anaesthetics are toxic in this setting has not been explored. Methods We exposed Ndufs4(−/−) mice, a model
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Therapeutic efficacy of intravenous lidocaine infusion compared with thoracic epidural analgesia in major abdominal surgery: a non-inferiority randomised clinical trial Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-26 Fabian D. Casas-Arroyave, Susana C. Osorno-Upegui, Mario A. Zamudio-Burbano
Background Open major abdominal surgery is one of the most risky surgical procedures for acute postoperative pain. Thoracic epidural analgesia (TEA) has been considered the standard analgesic approach. In different reports, lidocaine i.v. has been shown to have an analgesic efficacy comparable with TEA. We compared the analgesic efficacy of i.v. lidocaine with thoracic epidural analgesia using bupivacaine
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Evaluating cognitive aids in hospital management of severe trauma patients: a prospective randomised high-fidelity simulation trial Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-22 Maxime J.J. Fleury, Claire Nicolleau, Guillaume Bouhours, Mathieu Conté, Ludovic Martin, Sigismond Lasocki, Maxime Léger
Abstract not available
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Overview of the economic burden of musculoskeletal pain in children and adolescents: a systematic review with meta-analysis. Pain (IF 7.4) Pub Date : 2023-09-26 Caique de Melo Espirito Santo, Verônica S Santos, Steven J Kamper, Christopher M Williams, Gisela C Miyamoto, Tiê P Yamato
Studies suggest a high economic burden among children and adolescents with musculoskeletal pain. There is no summary in the literature on the overall economic burden of musculoskeletal pain in children and adolescents. The aim of this systematic review of cost-of-illness studies was to synthesize the economic burden of musculoskeletal pain in children and adolescents. We conducted electronic searches
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Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to alleviate trigeminal neuropathic pain. Pain (IF 7.4) Pub Date : 2023-09-26 Santiago I Loya-Lopez, Heather N Allen, Paz Duran, Aida Calderon-Rivera, Kimberly Gomez, Upasana Kumar, Rory Shields, Rui Zeng, Akshat Dwivedi, Saumya Saurabh, Olga A Korczeniewska, Rajesh Khanna
Dysregulation of voltage-gated sodium NaV1.7 channels in sensory neurons contributes to chronic pain conditions, including trigeminal neuropathic pain. We previously reported that chronic pain results in part from increased SUMOylation of collapsin response mediator protein 2 (CRMP2), leading to an increased CRMP2/NaV1.7 interaction and increased functional activity of NaV1.7. Targeting this feed-forward
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Large-scale momentary brain co-activation patterns are associated with hyperalgesia and mediate focal neurochemistry and cross-network functional connectivity in fibromyalgia. Pain (IF 7.4) Pub Date : 2023-09-26 Ishtiaq Mawla, Zirui Huang, Chelsea M Kaplan, Eric Ichesco, Noah Waller, Tony E Larkin, Helge J Zöllner, Richard A E Edden, Steven E Harte, Daniel J Clauw, George A Mashour, Vitaly Napadow, Richard E Harris
Fibromyalgia has been characterized by augmented cross-network functional communication between the brain's sensorimotor, default mode, and attentional (salience/ventral and dorsal) networks. However, the underlying mechanisms of these aberrant communication patterns are unknown. In this study, we sought to understand large-scale topographic patterns at instantaneous timepoints, known as co-activation
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Diversity, inclusion, and equity at the British Journal of Anaesthesia: 100 years of progress Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-25 Kate Leslie, Yize I. Wan, Cynthia A. Wong
The past century, especially the past decade, has seen re-examination and evolution in our views about sex, gender, race, and ethnicity. The British Journal of Anaesthesia is part of an ongoing effort in research and medical publishing, and in health and education more generally, to improve diversity, inclusion, and equity. This editorial highlights the contributions and evolution of the Journal in
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Neonatal Anesthesia, 2nd edn, J. Lerman (Ed.), Published by Springer, New York (2023), 637 pp. Price USD $219.99 hardcover, USD $169.00 ebook. ISBN No: 978-3-031-25357-7 Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-25 Susan M. Goobie
Abstract not available
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Utility of raw electroencephalography monitoring for estimating level of sedation in the perioperative setting Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-25 Alessandro Tani, Gennaro Tartarisco, Fiammetta Logi, Gabriella Martino, Sara Tudisco, Angelo Labate, Francesco Tomaiuolo
Abstract not available
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Global anaesthesia-related cardiac arrest rates in children: a systematic review and meta-analysis Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-22 Teofilo Augusto A. Tiradentes, Sharon Einav, Jose R.C. Braz, Vania S. Nunes-Nogueira, Marluci Betini, Jose E. Corrente, Mariana G. Braz, Leandro G. Braz
Background Neonates and infants have a higher perioperative risk of cardiac arrest and mortality than adults. The Human Development Index (HDI) ranges from 0 to 1, representing the lowest and highest levels of development, respectively. The relation between anaesthesia safety and country HDI has been described previously. We examined the relationship among the anaesthesia-related cardiac arrest rate
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Screening for hazardous attitudes among anaesthesiologists: a pilot study Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-22 John P. Rask, Huong-Tram Duran, Josh DeClercq, Michael Andreae, Shilo Anders, Arna Banerjee, Amanda R. Burden, Adam I. Levine, Matthew S. Shotwell, Elizabeth H. Sinz, Laurence C. Torsher, David M. Gaba, Matthew B. Weinger
Abstract not available
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Pre-operative assessment services and conduct in the West of Scotland region: a trainee research network audit Anaesthesia (IF 10.7) Pub Date : 2023-09-22 C. Hughes, L. Chalmers, A. Stark, I. Mactier, A. Tiah
The NHS is facing a massive backlog in elective surgical cases after the COVID-19 pandemic, with an estimated seven million people in the UK currently awaiting an elective procedure. Effective pre-operative assessment can identify patients at risk of postoperative complications, facilitate shared decision-making discussions and guide resource allocation to improve patient outcomes. In June 2021, the Centre
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Unrecognised oesophageal intubation: a sequential Bayesian exploration of clinical signs Anaesthesia (IF 10.7) Pub Date : 2023-09-22 J. Hansel, A. Higgs, T. M. Cook
We thank Drs Buchanan and Scott [1] for commenting on our review [2] and the opportunity to reply. They point out that clinical examination has several uses in airway management, including diagnosis of endobronchial intubation, pneumothorax and bronchospasm, but mistakenly suggest we discourage using clinical signs during the intubation sequence. In fact, our systematic review is silent about these
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Mediating effect of COVID-19 related negative sentiment on the relationship between COVID-19 infection indicators and burnout among Chinese anaesthesiologists in the post-pandemic era Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-21 Fu Zhang, Hua-Ming Liu, Yi-Fan Wang, Tian-Ying Tang, Hai-Bo Li, Yi-Sheng Huang, Yang-Tian Yan, Ke-Xuan Liu
Abstract not available
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Outcomes following perioperative red blood cell transfusion in patients undergoing elective major abdominal surgery: a systematic review and meta-analysis Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-21 Fraser J.D. Morris, Yoke-Lin Fung, Alison Craswell, Michelle S. Chew
Background Perioperative red blood cell transfusion is a double-edged sword for surgical patients. While transfusion of red cells can increase oxygen delivery by increasing haemoglobin levels, its impact on short- and long-term postoperative outcomes, particularly in patients undergoing elective major abdominal surgery, is unclear. Methods We conducted a systematic review and meta-analysis on the effect
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Superficial versus deep parasternal intercostal plane blocks: cadaveric evaluation of injectate spread Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-21 Rachel N. Douglas, Punnose Kattil, Nirusha Lachman, Rebecca L. Johnson, Adam D. Niesen, David P. Martin, Matthew J. Ritter
Background Deep and superficial parasternal intercostal plane blocks provide anterior chest wall analgesia for both breast and cardiac surgery. Our primary objective of this cadaveric study was to describe the parasternal spread of deep and superficial parasternal intercostal plane blocks. Our secondary objectives were to describe needle proximity to the internal mammary artery when performing deep
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Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-21 Yu-Qing Gao, Harald Ihmsen, Zhi-Yan Hu, Wei Sun, Yu-Bo Fang, Zhen Wang, Jürgen Schüttler, Christian Jeleazcov, Hua-Cheng Liu
Background The pharmacokinetic properties of the new benzodiazepine remimazolam have been studied only in adults. We investigated the pharmacokinetics of remimazolam after i.v. infusion in anaesthetised paediatric patients. Methods Twenty-four children (2–6 yr, ASA physical status 1–2, BMI 15–18 kg m−2) undergoing general anaesthesia with sevoflurane were enrolled. During surgery, remimazolam was administered
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Intraoperative hypotension and postoperative outcomes: a meta-analysis of randomised trials Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-20 Filippo D'Amico, Evgeny V. Fominskiy, Stefano Turi, Alessandro Pruna, Stefano Fresilli, Margherita Triulzi, Alberto Zangrillo, Giovanni Landoni
Introduction Intraoperative hypotension is associated with adverse postoperative outcomes; however these findings are supported only by observational studies. The aim of this meta-analysis of randomised trials was to compare the postoperative effects permissive management with targeted management of intraoperative blood pressure. Methods We searched PubMed, Cochrane, and Embase up to June 2023 for
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Opportunities for shared decision-making about major surgery with high-risk patients: the switch from ‘fixing the problem’ to undertaking shared decision-making. Comment on Br J Anaesth 2023; 131: 56–66 Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-20 Stuart Connal
Abstract not available
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Depth of anaesthesia monitoring: updated evidence. Comment on Br J Anaesth 2023; 131: 196–9 Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-19 Paul S. Myles
Abstract not available
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Reflections on bias raised in comparing videolaryngoscopy and flexible fibrescopy for tracheal intubation in patients with a cervical collar Anaesthesia (IF 10.7) Pub Date : 2023-09-19 S. Choi, H. Oh
We appreciate the insightful comments of Drs Cormier and Hyman [1] regarding our study [2]. Airway manoeuvres such as tongue traction and jaw thrust play an important role in successful fibrescopic tracheal intubation and the fact that not applying them may have prolonged the intubation time in our study has already been discussed in the limitations section. However, we would like to clarify that these
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Co-occurrence of chronic pain and anxiety/depression symptoms in U.S. adults: prevalence, functional impacts, and opportunities. Pain (IF 7.4) Pub Date : 2023-09-21 Jennifer S De La Rosa, Benjamin R Brady, Mohab M Ibrahim, Katherine E Herder, Jessica S Wallace, Alyssa R Padilla, Todd W Vanderah
Co-occurrence of chronic pain and clinically significant symptoms of anxiety and/or depression is regularly noted in the literature. Yet, little is known empirically about population prevalence of co-occurring symptoms, nor whether people with co-occurring symptoms constitute a distinct subpopulation within US adults living with chronic pain or US adults living with anxiety and/or depression symptoms
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Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease. Pain (IF 7.4) Pub Date : 2023-09-21 Yavnika Kashyap, Zaijie Jim Wang
Pain is the most common symptom experienced by patients with sickle cell disease (SCD) throughout their lives and is the main cause of hospitalization. Despite the progress that has been made towards understanding the disease pathophysiology, major gaps remain in the knowledge of SCD pain, the transition to chronic pain, and effective pain management. Recent evidence has demonstrated a vital role of
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A cognitive-behavioral digital health intervention for sickle cell disease pain in adolescents: a randomized, controlled, multicenter trial. Pain (IF 7.4) Pub Date : 2023-09-21 Tonya M Palermo, Chitra Lalloo, Chuan Zhou, Carlton Dampier, William Zempsky, Sherif M Badawy, Nitya Bakshi, Yeon Joo Ko, Fareha Nishat, Jennifer N Stinson
Severe acute and chronic pain are the most common complications of sickle cell disease (SCD). Pain results in disability, psychosocial distress, repeated clinic visits/hospitalizations, and significant healthcare costs. Psychosocial pain interventions that teach cognitive and behavioral strategies for managing pain have been effective in other adolescent populations when delivered in person or through
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Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice. Pain (IF 7.4) Pub Date : 2023-09-21 Ahmed Negm, Katharina Stobbe, Selma Ben Fradj, Clara Sanchez, Arnaud Landra-Willm, Margaux Richter, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Eric Lingueglia, Carole Rovere, Jacques Noel
Lipid-rich diet is the major cause of obesity, affecting 13% of the worldwide adult population. Obesity is a major risk factor for metabolic syndrome that includes hyperlipidemia and diabetes mellitus. The early phases of metabolic syndrome are often associated with hyperexcitability of peripheral small diameter sensory fibers and painful diabetic neuropathy. Here, we investigated the effect of high-fat
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Communication and activation in pain to enhance relationships and treat pain with equity (COOPERATE): a randomized clinical trial. Pain (IF 7.4) Pub Date : 2023-09-21 Marianne S Matthias, Joanne K Daggy, Anthony J Perkins, Jasma Adams, Matthew J Bair, Diana J Burgess, Johanne Eliacin, Perla Flores, Laura J Myers, Tetla Menen, Philip Procento, Kevin L Rand, Michelle P Salyers, Mackenzie L Shanahan, Adam T Hirsh
Racialized disparities in chronic pain care are well-documented and persist despite national priorities focused on health equity. Similar disparities have been observed in patient activation (ie, having the knowledge, confidence, and skills to manage one's health). As such, interventions targeting patient activation represent a novel approach to addressing and reducing disparities in pain care. Communication
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The use of cerebral CT angiography as an ancillary investigation to support a clinical diagnosis of death using neurological criteria Anaesthesia (IF 10.7) Pub Date : 2023-09-18 R. Sundaram, K. Rooney, S. K. Koteeswaran
We welcome the publication of the guideline by Thomas et al. [1]. It offers clear and comprehensive instructions on the indications, conduct and interpretation of 4-point CT angiography for ancillary testing to aid the confirmation of death by neurological criteria. However, the guideline does not include any specific comment on isolated infratentorial brain pathology or injury. The Faculty of Intensive
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Comparing performance of flexible bronchoscopy with videolaryngoscopy for awake tracheal intubation Anaesthesia (IF 10.7) Pub Date : 2023-09-18 F. S. Xue, X. Gao, L. Wan
Kamga et al. [1] evaluated the performance of the Airtraq® (Prodol Meditec S.A., Vizcaya, Spain) videolaryngoscope for awake flexible nasal bronchoscopy in patients with an anticipated difficult airway. To differentiate the effect of one factor on the primary outcome in a randomised controlled trial, all other factors must be standardised to avoid potential bias. However, other than the limitations
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Healthcare delivery gaps in pain management within the first 3 months after discharge from inpatient noncardiac surgeries: a scoping review Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-15 Janny X.C. Ke, Maya de Vos, Katarina Kojic, Mark Hwang, Jason Park, Heather Stuart, Jill Osborn, Alana Flexman, Lindsay Blake, Daniel I. McIsaac
Background Poor pain control during the postoperative period has negative implications for recovery, and is a critical risk factor for development of persistent postsurgical pain. The aim of this scoping review is to identify gaps in healthcare delivery that patients undergoing inpatient noncardiac surgeries experience in pain management while recovering at home. Methods Searches were conducted by
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Similarities in consciousness occurring during sleep and sedation Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-15 Andrew J.F. Turner, Jordan Wehrman, Robert D. Sanders
The subjective experiences of sedation or anaesthesia are underexplored. A recent study by Valli and colleagues (Br J Anaesth 2023; 131: 348–59) found similar frequency and content of recalled experiences after both non-rapid eye movement sleep and target-controlled infusions of propofol or dexmedetomidine titrated to verbal unresponsiveness. The authors find that the phenomenological similarities
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Consensus guidelines, Delphi methods, and evidence around anaesthetic technique for endoscopic retrograde cholangiopancreatography Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-15 Simon J. Howell, Anthony R. Absalom
Consensus guidelines on the anaesthetic management of endoscopic retrograde cholangiopancreatography (ERCP) have recently been published. The rigorous synthesis of expert opinion is invaluable when there are limited data, and these guidelines are a significant step forward. This review both guides practice and identifies important research questions. We challenge those working in this field to collaborate
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UK-wide rates of videolaryngoscopy use and barriers to universal uptake: a retrospective analysis of a multicentre observational study Anaesthesia (IF 10.7) Pub Date : 2023-09-15 J. Kua, T. Potter, D. J. N. Wong, E. Nurmi, K. El-Boghdadly, J. N. Cronin
The Project for Universal Management of Airways (PUMA) guidelines for prevention of unrecognised oesophageal intubation [1] recommend universal use of videolaryngoscopy for tracheal intubation whenever feasible. Potential barriers to implementation of this recommendation relate to criticism that it may reduce the experience that anaesthetists gain in direct laryngoscopy techniques [2], as well as lack
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Obstetric management strategies for pregnant patients receiving extracorporeal membrane oxygenation and associated maternal–fetal outcomes: a multicentre cohort study Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-15 Xing Hao, Chenglong Li, Chengcheng Shao, Feng Yang, Haixiu Xie, Xiaoyang Hong, Jinquan Wang, Shuanglei Li, Binfei Li, Dechang Chen, Xiaobo Huang, Jun Li, Xiaojun Liu, Jinsong Zhang, Haibo Qiu, Eddy Fan, Daniel Brodie, Hong Wang, Liangshan Wang, Xiaotong Hou
Abstract not available
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Basic analgesic use in randomised trials assessing local and regional analgesic interventions for mastectomy: a critical appraisal and clinical implications Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-15 Dan Mija, Henrik Kehlet, Girish P. Joshi
Regional analgesia is a core component of an optimal multimodal analgesia technique. Several advanced regional analgesic techniques have been evaluated for mastectomy; however, the optimal choice remains unclear. Many randomised clinical trials (RCTs) evaluating various local/regional analgesic techniques do not include basic analgesics (i.e. paracetamol, non-steroidal anti-inflammatory drugs, cyclooxygenase-2
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A classification system for pulmonary artery catheters Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-14 Matthias Heringlake, Karim Kouz, Bernd Saugel
Flow-directed, balloon-tipped pulmonary artery catheters allow measuring cardiac output and other haemodynamic variables including intracardiac pressures. We propose classifying pulmonary artery catheters by generations and specifying additional measurement modalities. Based on the method used to measure cardiac output, pulmonary artery catheters can be classified into three generations: first-generation
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Lessons from aviation safety: pilot monitoring, the sterile flight deck rule, and aviation-style computerised checklists in the operating room Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-14 Srdjan Jelacic, Andrew Bowdle, Bala G. Nair, Akira A. Nair, Mark Edwards, Daniel J. Boorman
Commercial aviation practices including the role of the pilot monitoring, the sterile flight deck rule, and computerised checklists have direct applicability to anaesthesia care. The pilot monitoring performs specific tasks that complement the pilot flying who is directly controlling the aircraft flight path. The anaesthesia care team, with two providers, can be organised in a manner that is analogous
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Quality of recovery after pericapsular nerve group (PENG) block for primary total hip arthroplasty under spinal anaesthesia. Comment on Br J Anaesth 2023; 130: 773–9 Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-14 Anders H. Springborg, Niklas I. Nielsen, Nicolai B. Foss
Abstract not available
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Global practices in desflurane use Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-14 Elizabeth P. Hu, Andrea Yap, Jessica F. Davies, Toru Goyagi, Forbes McGain
Abstract not available
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Both patients and the public should be involved in setting the pain research agenda Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-14 Ketan Bhatt, Dalia M. Aljohani, Patrice Forget
Abstract not available
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Critical care and pandemic preparedness and response Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-14 William RN. Thomson, Zudin A. Puthucheary, Yize I. Wan
Critical care was established partially in response to a polio epidemic in the 1950s. In the intervening 70 yr, several epidemics and pandemics have placed critical care and allied services under extreme pressure. Pandemics cause wholesale changes to accepted standards of practice, require reallocation and retargeting of resources and goals of care. In addition to clinical acumen, mounting an effective
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Early-in-life isoflurane exposure alters resting-state functional connectivity in juvenile non-human primates Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-14 Viola Neudecker, Jose F. Perez-Zoghbi, Oscar Miranda-Domínguez, Katie J. Schenning, Julian SB. Ramirez, A.J. Mitchell, Anders Perrone, Eric Earl, Sam Carpenter, Lauren D. Martin, Kristine Coleman, Martha Neuringer, Christopher D. Kroenke, Gregory A. Dissen, Damien A. Fair, Ansgar M. Brambrink
Background Clinical studies suggest that anaesthesia exposure early in life affects neurobehavioural development. We designed a non-human primate (NHP) study to evaluate cognitive, behavioural, and brain functional and structural alterations after isoflurane exposure during infancy. These NHPs displayed decreased close social behaviour and increased astrogliosis in specific brain regions, most notably
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Inhibitory effects of lidocaine on colon carcinoma progression in a rat model: a pilot study Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-13 Sergiu D. Habago, Valentin Ordodi, Florina Bojin, Stefan C. Vesa, Valentin Moldovan, Virgil Paunescu, Daniela Ionescu
Abstract not available
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Expectations underlie the effects of unpredictable pain: a behavioral and electroencephalogram study. Pain (IF 7.4) Pub Date : 2023-09-13 Fabien Pavy, Jonas Zaman, Andreas Von Leupoldt, Diana M Torta
Previous studies on the potential effects of unpredictability on pain perception and its neural correlates yielded divergent results. This study examined whether this may be explained by differences in acquired expectations. We presented 41 healthy volunteers with laser heat stimuli of different intensities. The stimuli were preceded either by predictable low, medium, or high cues or by unpredictable
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Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons. Pain (IF 7.4) Pub Date : 2023-09-13 Jiwon Yi, Zachariah Bertels, John Smith Del Rosario, Allie J Widman, Richard A Slivicki, Maria Payne, Henry M Susser, Bryan A Copits, Robert W Gereau
Bradykinin is a peptide implicated in inflammatory pain in both humans and rodents. In rodent sensory neurons, activation of B1 and B2 bradykinin receptors induces neuronal hyperexcitability. Recent evidence suggests that human and rodent dorsal root ganglia (DRG), which contain the cell bodies of sensory neurons, differ in the expression and function of key GPCRs and ion channels; whether bradykinin
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The genetic variant SLC2A1-rs1105297 is associated with the differential analgesic response to a glucose-based treatment in newborns. Pain (IF 7.4) Pub Date : 2023-09-13 Riccardo Farinella, Fabio Falchi, Arianna Tavanti, Cristina Tuoni, Maria Grazia Di Nino, Luca Filippi, Massimiliano Ciantelli, Cosmeri Rizzato, Daniele Campa
Neonatal pain is a critical issue in clinical practice. The oral administration of glucose-based solutions is currently one of the most common and effective nonpharmacologic strategies for neonatal pain relief in daily minor procedures. However, a varying degree of analgesic efficacy has been reported for this treatment. Environmental, maternal, and genetic factors may explain this variability and
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PUMA guidelines: a fail-safe when sustained exhaled carbon dioxide is absent following attempted tracheal intubation Anaesthesia (IF 10.7) Pub Date : 2023-09-10 A. Higgs, N. Chrimes, J. P. Nolan, T. M. Cook
We welcome the continuing discussion around the international consensus guideline for the prevention of unrecognised oesophageal intubation [1] as applied to cardiopulmonary resuscitation [2, 3]. Qureshi et al. share a vignette (unrelated to cardiopulmonary resuscitation) intended to highlight how adhering to the guideline might have caused harm. Yet the actions they advocate are entirely consistent
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More on deaths from unrecognised oesophageal intubation Anaesthesia (IF 10.7) Pub Date : 2023-09-10 T. M. Cook, J. Hansel, N. Chrimes
Dr Lyons [1] raises several questions about the consensus guidelines on prevention of unrecognised oesophageal intubation [2] and the Cochrane review of videolaryngoscopy vs. direct laryngoscopy [3]. He asks “Who is putting the tube in the oesophagus?” The answer is 3% of intubators who use direct laryngoscopy [4]. From review of numerous cases of fatal oesophageal intubation (https://www.universalairway
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Importance of standardisation and human factors in ensuring patient safety with videolaryngoscopes Anaesthesia (IF 10.7) Pub Date : 2023-09-10 A. Lotlikar, E. Martinoni Hoogenboom
The growing body of evidence supporting the safety profile and success rates of videolaryngoscopy is likely to result in a wider range of these devices being made available for clinical use. The importance of human factors in anaesthesia with regard to improving patient safety has already been described by Kelly et al. [1]. Design is the most effective strategy to reduce errors and enhance patient
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Tranexamic acid for reduction of blood loss after Caesarean delivery: a cost-effectiveness analysis of the TRAAP2 trial Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-09 Loïc Sentilhes, Antoine Bénard, Hugo Madar, Alizée Froeliger, Solène Petit, Catherine Deneux-Tharaux
Background Prophylactic administration of tranexamic acid is associated with a reduction of blood loss after Caesarean delivery, but cost-effectiveness for this indication has not been assessed. Methods We used data from the TRAAP2 trial, a multicentre, double-blinded, RCT aimed at estimating the efficacy of tranexamic acid for preventing postpartum haemorrhage among women undergoing Caesarean delivery
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Serratus anterior and pectoralis plane blocks for robotically assisted mitral valve repair. Response to Br J Anaesth 2023 Br. J. Anaesth. (IF 9.8) Pub Date : 2023-09-09 Andrej Alfirevic, Daniel I. Sessler, Xuan Pu, Alparslan Turan
Abstract not available