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The 9-member Editorial Board of the American Society for Gastrointestinal Endoscopy (ASGE) performed a systematic literature search of original articles published during 2021 in Gastrointestinal Endoscopy (GIE) and 10 other high-impact medical and gastroenterology journals on endoscopy-related topics. Votes from each Editorial Board member were tallied to identify a consensus list of the 10 most significant

Background and Aims Despite advances in endoscopic therapies, malignancy-related gastrointestinal (GI) bleeding remains difficult to manage with high rates of treatment failure and rebleeding. Topical hemostatic agents (THA) are easier to apply to the wide bleeding surface of tumors. We conducted this systematic review and meta-analysis to evaluate the efficacy of THAs in malignancy-related GI bleed

Background Although a common pathogen in much of Asia, liver flukes are thought to be a rare cause of disease in the United States. In this series, we describe three patients diagnosed with Clonorchis sinensis during endoscopic retrograde cholangiopancreatography (ERCP) within one-year at our institution. Methods Three patients referred to a large community hospital underwent ERCP with direct visualization

BACKGROUND & AIMS Upper gastrointestinal (GI) endoscopy is speculated to be an aerosol-generating procedure (AGP). Robust evidence exists for aerosol transmission of SARS-CoV-2. The quality of data available confirming aerosol generation during GI endoscopy is limited. We aimed to objectively demonstrate that GI endoscopy is an AGP and illustrate the mechanism by which the greatest risk for aerosolization

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BACKGROUND Assessment of endoscopic ultrasound (EUS) guided fine needle tissue adequacy by macroscopic on-site evaluation (MOSE) is gathering attention. Studies report good diagnostic parameters with MOSE; however, the overall data is limited. We conducted this systematic review and meta-analysis to report on the pooled diagnostic assessment parameters of EUS-guided tissue acquisition by MOSE using

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Background and Aims Early gastric cancer (EGC) detection rate is unsatisfactory, and mastering the diagnostic skills of magnifying endoscopy with narrow-band imaging (ME-NBI) requires rich expertise and experience. We aimed to develop an EGC captioning model (EGCCap) to automatically describe the visual characteristics of ME-NBI images for endoscopists. Methods A total of 1886 ME-NBI images from 294

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Background and aims Endoscopic sleeve gastroplasty (ESG) is an incisionless, transoral, restrictive bariatric procedure designed to imitate sleeve gastrectomy (SG). Comparative studies are limited and there is a lack of large-scale population-based data. Additionally, no studies have examined the impact of race on outcomes after ESG. This study aims to compare short-term outcomes of ESG to SG and evaluate

Background and Aims Traditionally, palliative treatment of malignant gastric outlet obstruction (GOO) has been surgical. Nevertheless, it associates significant morbidity and mortality rates. Endoscopic placement of a duodenal self-expandable metal stent (D-SEMS) has been proven to be successful for this indication in the short-term. However, D-SEMS are likely to malfunction over time. EUS-guided gastroenterostomy

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Background and Aims Therapy and prognosis of pancreatic neuroendocrine tumors (PanNENs) are strictly related to Ki-67 index which defines tumor grading (G). The gold standard for the assessment of PanNENs’ grading is endoscopic ultrasound-fine needle aspiration/biopsy (EUS-FNA/B). As data on diagnostic accuracy of EUS-FNA/B are heterogenous we aimed to analyze the variability in concordance between

Background and Aims This study aimed to assess the long-term survival of patients with T1 colorectal cancer following local or surgical resection considering the type and number of risk factors for lymph node metastasis. Methods This study included patients with high-risk T1 colorectal cancer who underwent therapeutic resection at the National Cancer Center, Korea between January 2001 and December

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Background and Aims Optimal bowel preparation before capsule endoscopy (CE) is currently unknown. In this multicenter, blinded, randomized controlled trial, we assessed clinical effectiveness of two types of purgative regimen and a control arm of clear fluid (CF) only. Methods Patients with suspected small intestinal bleeding were randomized to 3 arms: A) CF only for 18 hours before CE and simethicone

Background & Aims Measuring adenoma detection rate (ADR) at the population-level is challenging because pathology reports are often reported in an unstructured format; further, there is significant variation in reporting methods across institutions. Natural language processing (NLP) can be used to extract relevant information from text-based records. We aimed to develop and validate an NLP algorithm

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Background and Aims Upper gastro-intestinal bleeding is a common condition associated with significant morbidity and mortality. Endoscopic hemostasis remains the mainstay of therapy and is mainly aimed at effective hemostasis and prevention of rebleeding. Lesions with high-risk stigmata can have rebleeding rates of as high as 26.3%. Rebleeding is associated with increased mortality and reduced success

Background and Aims Tip-in endoscopic mucosal resection (EMR), which includes anchoring the snare tip, has recently shown a favorable en bloc and R0 resection rate for colorectal neoplasms. Thus, Tip-in EMR may be an alternative to endoscopic submucosal dissection (ESD). We aimed to compare clinical outcomes between Tip-in EMR and ESD for large colorectal neoplasms. Methods This retrospective study

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Background and Aims Endoscopic mucosal resection (EMR) is the mainstay of therapy for large colorectal polyps. Local recurrence after EMR is common and can be reduced using margin ablation. Our aim was to evaluate recurrence rates when using hybrid argon plasma coagulation - HybridAPC® (h-APC) -ablation after EMR. Methods Adult patients (18–89 years) undergoing EMR of nonpedunculated colorectal polyps

Background and aims During endoscopy, droplets with the potential to transmit COVID-19 are known to emanate from a patient’s mouth and anus, but they may also be expelled from the biopsy channel of the endoscope. The main goal of our study was to quantify droplets emerging from the biopsy channel during clinical endoscopy. Methods A novel light scattering device was used to measure droplets emanating

Background and Aims Endoscopic resection is a feasible treatment for gastrointestinal extraluminal tumors, but remains a challenging procedure with limited data. In this study, we assessed the safety and efficacy of endoscopic resection for extraluminal tumors in the upper gastrointestinal tract. Methods From May 2016 to December 2021, 109 patients undergoing endoscopic resection for extraluminal tumors

Background and aims Focal cryoballoon ablation (FCBA) is currently investigated for the treatment of Barrett’s esophagus (BE) related neoplasia in a European multicenter study (Euro-Coldplay study). After inclusion of 28/107 patients, the initial dose of 10 seconds (s) was lowered to 8s. The current study aimed to compare the efficacy and safety of a single FCBA treatment session with 10s versus 8s

Background and Aims Optical diagnosis (OD) of polyps can be performed with advanced endoscopic imaging. For high confidence diagnoses, a “resect and discard” strategy could offer significant histopathology time and cost savings. The implementation threshold is a ≥90% OD-histology surveillance interval concordance. Aims: assess OD learning curve and feasibility of “resect and discard” strategy for ≤5mm

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Background and aims The risk of progression in Barrett’s esophagus (BE) increases with development of dysplasia. There is a critical need to improve the diagnosis of BE dysplasia, given substantial interobserver disagreement among expert pathologists and overcalls of dysplasia by community pathologists. We developed a deep learning model to predict dysplasia grade on whole slide imaging. Methods We

Background and Aims The large-scale effects of duodenoscopes on the environment and public health have not been quantified. Our aim was to perform an exploratory Life Cycle Assessment (LCA) comparing environmental and human health effects of single-use (SD) and reusable duodenoscopes (RD). Methods We evaluated three duodenoscopes: 1) conventional RD; 2) RD with disposable endcaps; and 3) SD. The primary

Background and Aims Newly designed duodenoscopes with disposable distal caps have been developed for better cleaning and preprocessing to reduce the risk of bacterial contamination (BC). We compared BC and organic residue of duodenoscopes with disposable distal caps and duodenoscopes with fixed distal caps after manual cleaning and high-level disinfection (HLD). Methods 400 duodenoscopes were randomized

Background and Aims The clinical application of gastrointestinal endoscopy for the diagnosis of multiple diseases using artificial intelligence (AI) has been limited by its high false positive rates. There is an unmet need to develop a Gastrointestinal Endoscopy AI-assisted Diagnosis System (GEADS) to improve diagnostic accuracy and clinical utility. Methods In this retrospective, multicenter study

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