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Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-13 Jiarong Fu,Catherine Mansfield,Ivan Diakonov,Aleksandra Judina,Matthew Delahaye,Navneet Bhogal,Jose L Sanchez-Alonso,Timothy Kamp,Julia Gorelik
AIMS Caveolin-3 is essential for the formation of caveolae in cardiomyocytes. Caveolar microdomains have been shown to regulate the distribution of signalling proteins such as beta-adrenoceptors (βAR) and may act as membrane reserves to protect the cell from damage during the mechanical stretch. Myocardial stretch occurs during haemodynamic overload and may be normal (e.g. exercise) or pathological
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Colchicine and stabilization of coronary artery plaques. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-13 Valtteri Muroke,Jean-Claude Tardif
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Angiotensin 1-7 and a TERT activator individually restore vasodilatory capacity within the microcirculation previous SARS-CoV-2 infection. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-13 Yoshinori Nishijima,Shelby N Hader,Erin C Birch,Yiliang Chen,Michael E Widlansky,Andreas M Beyer
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Immune cells and arrhythmias Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-11 Joshua A Keefe, Jian Wang, Jiangping Song, Li Ni, Xander Wehrens
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide. Emerging evidence has demonstrated that resident and infiltrating cardiac immune cells play direct, mechanistic roles in arrhythmia onset and progression. In this review, we provide a comprehensive summary and expert commentary on the role of each immune cell subtype in the pathogenesis of atrial and ventricular arrhythmias
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Emerging role of Cellular communication network factor 2 (CCN2) as a guardian of smooth muscle cell phenotype and vascular integrity. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-11 J H Larsen,L B Steffensen
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Glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist tirzepatide promotes branched chain amino acid catabolism to prevent myocardial infarction in non-diabetic mice. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-10 Mengya Chen,Nan Zhao,Wenke Shi,Yun Xing,Shiqiang Liu,Xianxian Meng,Lanlan Li,Heng Zhang,Yanyan Meng,Saiyang Xie,Wei Deng
AIMS A novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptor agonist, tirzepatide (LY3298176, TZP), has been developed to treat Type 2 diabetes mellitus (T2DM). In ischaemic heart diseases, TZP is involved in cardiac metabolic processes. However, its efficacy and safety in treating heart failure (HF) following myocardial infarction (MI) remain uncertain. METHODS
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Redirecting glucose into anabolic pathways participates in the protective effects of NRF2 activation in the heart under stress. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-10 Thomas Eschenhagen
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Interleukin-37 attenuates aortic valve lesions by inhibiting m6A-mediated IRAK-M degradation Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-05 Gaopeng Xian, Rong Huang, Dongtu Hu, Minhui Xu, Yangchao Chen, Hao Ren, Dingli Xu, Qingchun Zeng
Aims Calcific aortic valve disease (CAVD) has become an increasingly important global medical problem without effective pharmacological intervention. Accumulating evidence indicates that aortic valve calcification is driven by inflammation. Interleukin-1 receptor-associated kinase M (IRAK-M) is a well-known negative regulator of inflammation, but its role in CAVD remains unclear. Methods and Results
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Cardioprotective effects of a 'twincretin' drug tirzepatide in heart failure following myocardial infarction. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-04 Rui Shang,Brian Rodrigues
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CircRNAs increase during vascular cell differentiation and are biomarkers for vascular disease Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-04 Bernd H Northoff, Andreas Herbst, Catharina Wenk, Lena Weindl, Gabor Gäbel, Andre Brezski, Kathi Zarnack, Alina Küpper, Stefanie Dimmeler, Alessandra Moretti, Karl-Ludwig Laugwitz, Stefan Engelhardt, Lars Maegdefessel, Reinier Boon, Stefanie Doppler, Martina Dreßen, Harald Lahm, Rüdiger Lange, Markus Krane, Knut Krohn, Alexander Kohlmaier, Lesca M Holdt, Daniel Teupser
Aims The role of circular RNAs (circRNAs) and their regulation in health and disease are poorly understood. Here, we systematically investigated the temporally resolved transcriptomic expression of circRNAs during differentiation of human induced pluripotent stem cells (iPSC) into vascular endothelial cells (EC) and smooth muscle cells (SMC) and explored their potential as biomarkers for human vascular
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Single cell RNA sequencing of hematopoietic cells in fresh and frozen human atheroma tissue Cardiovasc. Res. (IF 10.2) Pub Date : 2025-02-03 Herra Ahmad, J k Gopakumar, Daniel C Nachun, Lisa Ma, Jessica D’Addabbo, Xianxi Huang, Tiffany Koyano, Jack Boyd, Y Joseph Woo, Robyn Fong, Oliver Aalami, Patricia K Nguyen, Siddhartha Jaiswal
Aims Single-cell RNA sequencing (scRNA-seq) is a powerful method for exploring the cellular heterogeneity within human atheroma but typically requires fresh tissue to preserve cell membrane integrity, limiting the feasibility of large-scale biobanking for later analysis. The aim of this study was to determine whether cryopreservation of fragile and necrotic atheroma tissue affects the viability and
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Incretin-based weight loss therapies and heart failure with preserved ejection fraction: guideline impactful results, but mechanisms unclear. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-31 Katarzyna Stefanska,Naveed Sattar
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Downregulation of HDAC2 attenuates ventricular arrhythmias in a mouse model of cardiac hypertrophy through upregulation of KCHIP2 expression. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-28 Wenjuan Liu,Jianping Liu,Gang Wang,Wanwen Cheng,Haochen Gong,Yujuan Song,Ming Song,Yixin Zhuge,Ying Li,Jie Liu
AIMS Decrease in repolarizing K+ currents, particularly the fast component of transient outward K+ current (Ito,f), prolongs action potential duration (APD) and predisposes the heart to ventricular arrhythmia during cardiac hypertrophy. Histone deacetylases (HDACs) have been suggested to participate in the development of cardiac hypertrophy, and class I HDAC inhibition has been found to attenuate pathological
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Cardioprotection with nebivolol in patients undergoing anthracyclines: a randomized placebo-controlled trial. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-22 Giulio Stefanini,Carmelo Carlo-Stella,Francesco Cannata,Mauro Chiarito,Stefano Figliozzi,Laura Novelli,Costanza Lisi,Sara Bombace,Federica Catapano,Eleonora Indolfi,Cristina Panico,Francesco Corrado,Giovanna Masci,Rita Mazza,Francesca Ricci,Lorenzo Monti,Giuseppe Ferrante,Bernhard Reimers,Armando Santoro,Marco Francone,Bruno R da Costa,Peter Jüni,Gianluigi Condorelli
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Modulation of amygdala and hippocampus during anxiety by heart and middle frontal gyrus. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-21 Gert Pfurtscheller,Beate Rassler,Alberto Porta,Gerhard Schwarz,Maciej Kaminski,Klaus Pfurtscheller,Wolfgang Klimesch
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Dedicator of Cytokinesis 2 regulates cytoskeletal actin dynamics and is essential for platelet biogenesis and functions Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-21 Jiani Ji, Xulin Xu, Lili Zhang, Shuang Liu, Jiayi Chen, Huihui Gao, Limin Xiang, Yaofeng Li, Hui Xu, Yaobing Chen, Huiqin Xiang, Shuai Chen, Yunyun Han, Zhaoming Tang, Xuanbin Wang, Xiaofeng Shi, Jianhua Mao, Xiaodong Xi, Jinyu Wang, Chao Fang
Aims Dedicator of Cytokinesis 2 (DOCK2), a member of the DOCK family of Guanine nucleotide exchange factors that specifically act on the Rho GTPases including Rac and Cdc42, plays pivotal roles in the regulation of leukocyte homeostasis. However, its functions in platelets remain unknown. Methods and Results Using mice with genetic deficiency of DOCK2 (Dock2-/-), we showed that Dock2-/-mice exhibited
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Therapeutic potential of ketone bodies on exercise intolerance in heart failure: looking beyond the heart Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-18 Shubham Soni, Rachel J Skow, Stephen Foulkes, Mark J Haykowsky, Jason R B Dyck
Recent evidence suggests that ketone bodies have therapeutic potential in many cardiovascular diseases including heart failure (HF). Accordingly, this has led to multiple clinical trials that use ketone esters to treat HF patients, which we term ketone therapy. Ketone esters, specifically ketone monoesters, are synthetic compounds which, when consumed, are de-esterified into two β-hydroxybutyrate (βOHB)
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Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-13 Ellen G Avery, Lea-Maxie Haag, Victoria McParland, Sarah M Kedziora, Gabriel J Zigra, Daniela S Valdes, Marieluise Kirchner, Oliver Popp, Sabrina Geisberger, Olivia Nonn, Tine V Karlsen, Gabriele N’Diaye, Alex Yarritu, Hendrik Bartolomaeus, Theda U P Bartolomaeus, Nurana A Tagiyeva, Moritz I Wimmer, Nadine Haase, Yiming D Zhang, Andreas Wilhelm, Gerald Grütz, Olav Tenstad, Nicola Wilck, Sofia K Forslund
Aims The gastrointestinal (GI) tract is composed of distinct sub-regions, which exhibit segment-specific differences in microbial colonization and (patho)physiological characteristics. Gut microbes can be collectively considered as an active endocrine organ. Microbes produce metabolites, which can be taken up by the host and can actively communicate with the immune cells in the gut lamina propria with
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Arachidonic acid synergizes with aspirin preventing myocardial ischemia-reperfusion injury and mitigates bleeding risk Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-09 Shaletanati Talabieke, Xuejian Yang, Jianfeng Yang, Qing Wan, Dekun Zhu, Haojie Rao, Yifei Wu, Zengrong Chen, Huihui Li, Pengfei Xu, Hong Chen, De-Pei Liu, Xu Zhang, Garret A FitzGerald, Miao Wang
Aims The therapeutic efficacy of coronary revascularization is compromised by myocardial ischemia-reperfusion (MI/R) injury. Higher levels of circulating arachidonic acid (AA) are reportedly associated with lower risk of cardiovascular disease. The cyclooxygenase (COX) pathway metabolizes AA into prostaglandins (PGs) and the platelet-activating thromboxane A2 (TXA2), which is inhibited by aspirin.
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RNA epigenetic modifications: a new field of research in calcific aortic valve disease. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-07 Mewen Briend,Patrick Mathieu
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Chemokine receptor-directed imaging, prognostication, and treatment of abdominal aortic aneurysm: can we do it all with CXCR4? Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-06 Martin Andreas,Irene M Lang
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A novel approach to modeling acute cardiac decompensation in rats. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-06 Arne Thiele,Hendrik Bartolomaeus,Harithaa Anandakumar,Nadine Haase,Arnd Heuser,Dominik N Müller,Ralf Dechend,Nicola Wilck
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Cardioprotection exerted by intravenous statin at index myocardial infarction event attenuates cardiac damage upon recurrent infarction Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-02 Gemma Vilahur, Soumaya Ben-Aicha, Manuel Gutiérrez, Monika Radike, Guiomar Mendieta, Lisaidy Ramos, Sebastia Alcover, Laura Casani, Gemma Arderiu, Teresa Padró, María Borrell, Lina Badimon
Aims Recurrent acute myocardial infarction (RE-AMI) is a frequent complication after STEMI, and its association with stent thrombosis can be life-threatening. Intravenous atorvastatin (IV-atorva) administration during AMI has been shown to limit infarct size and adverse cardiac remodeling. We determined by cardiac magnetic resonance (CMR) whether the cardioprotection exerted by IV-atorva at the index
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Taming the flame: SerpinB1 suppression of pyroptosis in pathological cardiac hypertrophy. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-01-02 Beatrijs Bartelds,Daphne Merkus
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SGLT2 expression in human vasculature and heart correlates with low-grade inflammation and causes eNOS-NO/ROS imbalance Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-31 Ali Mroueh, Paola Algara-Suarez, Walaa Fakih, Dal-Seong Gong, Kensuke Matsushita, Sin-Hee Park, Said Amissi, Cyril Auger, Gilles Kauffenstein, Nicolas Meyer, Patrick Ohlmann, Laurence Jesel, Michael Paul Pieper, Benjamin Marchandot, Olivier Morel, Jean-Philippe Mazzucotelli, Valérie B Schini-Kerth
Aims Sodium-glucose co-transporter 2 inhibitors (SGLT2i) show a cardioprotective effect in heart failure and myocardial infarction, pathologies often associated with low-grade inflammation. This cross-sectional study aims to investigate whether low-grade inflammation regulates SGLT2 expression and function in human vasculature, heart, and endothelial cells (ECs). Methods and results Human internal
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Iron, lipid peroxidation, and ferroptosis play pathogenic roles in atherosclerosis Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-31 Swetha Jinson, Ziyang Zhang, Graeme I Lancaster, Andrew J Murphy, Pooranee K Morgan
Oxidation of lipids, excessive cell death, and iron deposition are prominent features of human atherosclerotic plaques. While extensive research has established the detrimental roles of lipid oxidation and apoptosis in atherosclerosis development, the involvement of iron in atherogenesis is not yet fully understood. With the emergence of an iron-dependent form of cell death termed ferroptosis, new
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Metformin treatment in hyperglycemic INOCA patients. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-30 Pasquale Mone,Fahimeh Varzideh,Antonio Rainone,Urna Kansakar,Stanislovas S Jankauskas,Luigi Salemme,Maria Chiara Brunese,Giuseppe Speziale,Tullio Tesorio,Gaetano Santulli
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Brainstem C1 neurons mediate heart failure decompensation and mortality during acute salt loading Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-30 Karla G Schwarz, Katherin V Pereyra, Esteban Díaz-Jara, Sinay C Vicencio, Rodrigo Del Rio
Aims Heart failure (HF) is an emerging epidemic worldwide. Despite advances in treatment, the morbidity and mortality rate of HF remain high, and the global prevalence continues to rise. Common clinical features of HF include cardiac sympathoexcitation, disordered breathing, and kidney dysfunction; kidney dysfunction strongly contributes to sodium retention and fluid overload, leading to poor outcomes
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Acetylation-ubiquitination crosstalk of DJ-1 mediates microcalcification formation in diabetic plaques via collagen-matrix vesicles interaction Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-30 Zhen Sun, Lihua Li, Yao Wu, Lili Zhang, Guangyao Zang, Yongjiang Qian, Haipeng Yao, Xiang Mao, Zhongqun Wang
Aims Microcalcification increases the vulnerability of plaques and has become an important driver of acute cardiovascular events in diabetic patients. However, the regulatory mechanisms remain unclear. DJ-1, a multifunctional protein, may play a potential role in the development of diabetic complications. Therefore, this study aims to explore the relationship between DJ-1 and microcalcification in
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Meis transcription factors regulate cardiac conduction system development and adult function Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-18 Noelia Muñoz-Martín, Ana Simon-Chica, Covadonga Díaz-Díaz, Vanessa Cadenas, Susana Temiño, Isaac Esteban, Andreas Ludwig, Barbara Schormair, Juliane Winkelmann, Veronika Olejnickova, David Sedmera, David Filgueiras-Rama, Miguel Torres
Aims The cardiac conduction system (CCS) is progressively specified during development by interactions among a discrete number of transcription factors (TFs) that ensure its proper patterning and the emergence of its functional properties. Meis genes encode homeodomain TFs with multiple roles in mammalian development. In humans, Meis genes associate with congenital cardiac malformations and alterations
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SerpinB1 targeting safeguards against pathological cardiac hypertrophy and remodelling by suppressing cardiomyocyte pyroptosis and inflammation initiation Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-17 Cong Lan, Guangyao Fang, Xiuchuan Li, Xiao Chen, Yingmei Chen, Tao Hu, Xuenan Wang, Huiling Cai, Jiajin Hao, Haoran Li, Yan Zhang, Ke Peng, Zaicheng Xu, Dachun Yang, Xia Kang, Qian Xin, Yongjian Yang
Aims While the pivotal role of inflammation in pathological cardiac hypertrophy and remodelling is widely acknowledged, the mechanisms triggering inflammation initiation remain largely obscure. This study aims to elucidate the role and mechanism of serpin family B member 1 (SerpinB1) in pro-inflammatory cardiomyocyte pyroptosis, heart inflammation, and cardiac remodelling. Methods and results C57BL/6J
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Correction to: Cellular mechanisms of oligoclonal vascular smooth muscle cell expansion in cardiovascular disease. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-16
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CXCR4-targeted sensitive magnetic particle imaging for abdominal aortic aneurysm early detection and prognosis evaluation by recognizing total inflammatory cells Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-11 Genmao Cao, Ruijing Zhang, Xiaohua Jia, Bo Jiang, Yaling Li, Xuezhen Xuan, Jie Tian, Hui Hui, Shijie Xin, Honglin Dong
Aims The maximum aortic diameter remains the diagnostic criteria and the indicator for prognosis prediction of abdominal aortic aneurysms (AAAs). An additional imaging modality is currently needed to help evaluate the prognosis of AAA as well as early detection of AAA formation. This study evaluated the most effective inflammatory markers for AAA using single-cell sequencing and, from these, developed
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Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3 Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-11 Ahmed M Darwesh, Liye Fang, Tariq R Altamimi, K Lockhart Jamieson, Wesam Bassiouni, Robert Valencia, Andy Huang, Faqi Wang, Hao Zhang, Marawan Ahmed, Keshav Gopal, Yongneng Zhang, Evangelos D Michelakis, John R Ussher, Matthew L Edin, Darryl C Zeldin, Khaled Barakat, Gavin Y Oudit, Zamaneh Kassiri, Gary D Lopaschuk, John M Seubert
Aims Although current clinical therapies following myocardial infarction (MI) have improved patient outcomes, morbidity, and mortality rates, secondary to ischaemic and ischaemia reperfusion (IR) injury remains high. Maintaining mitochondrial quality is essential to limit myocardial damage following cardiac ischaemia and IR injury. The mitochondrial deacetylase sirtuin 3 (SIRT3) plays a pivotal role
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The N6-methyladenosine demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-11 Yueheng Wang, Shengping He, Lan Lan, Hongjiao Yu, Huan Zhao, Yuchen Xie, Guoli Zhong, Liang Yuan, Kun Li, Xiao Hu, Vicky E Macrae, Xiaodong Fu, Guojun Chen, Dongxing Zhu
Aims Calcific aortic valve disease (CAVD) is a common heart valve disease with significant clinical consequences. The mechanisms that drive the pathogenesis of CAVD remain to be fully elucidated. N6-methyladenosine (m6A), the most prevalent RNA epigenetic regulator, has recently been implicated in cardiovascular disease, but its role in CAVD has yet to be investigated. In this study, we investigated
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NRF2 activation in the heart induces glucose metabolic reprogramming and reduces cardiac dysfunction via upregulation of the pentose phosphate pathway Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-10 Anna Zoccarato, Ioannis Smyrnias, Christina M Reumiller, Anne D Hafstad, Mei Chong, Daniel A Richards, Celio X C Santos, Asjad Visnagri, Sharwari Verma, Daniel I Bromage, Min Zhang, Xiaohong Zhang, Greta Sawyer, Richard Thompson, Ajay M Shah
Aims The transcription factor nuclear factor erythroid–derived 2-like 2 (NRF2) is well recognized as a master regulator of antioxidant responses and cytoprotective genes. Previous studies showed that NRF2 enhances the resistance of mouse hearts to chronic haemodynamic overload, at least in part by reducing oxidative stress. Evidence from other tissues suggests that NRF2 may modulate glucose intermediary
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When cell mechanics meets epitranscriptomics: reduction of m6A in Piezo2 RNA ameliorates cardiac fibrosis. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-31 Gloria Garoffolo,Maurizio Pesce
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Anaplerotic filling in heart failure: a review of mechanism and potential therapeutics Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-21 Karm A Alhasan, Melissa A King, Badal S B Pattar, Ian A Lewis, Gary D Lopaschuk, Steven C Greenway
Heart failure (HF) is a complex syndrome and a leading cause of mortality worldwide. While current medical treatment is based on known pathophysiology and is effective for many patients, the underlying cellular mechanisms are poorly understood. Energy deficiency is a characteristic of HF, marked by complex alterations in metabolism. Within the tricarboxylic acid cycle, anaplerosis emerges as an essential
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On the cusps of the second heart field: insights from zebrafish into arterial valve origins and disease. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-21 Robert G Kelly
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TGF-β signalling: the Dr Jekyll and Mr Hyde of the aortic aneurysms. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-31 Sara Perrotta,Daniela Carnevale,Giuseppe Lembo
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C–C Motif chemokine receptor-2 blockade ameliorates pulmonary hypertension in rats and synergizes with a pulmonary vasodilator Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-18 Naoki Tsuboya, Hirofumi Sawada, Yoshihide Mitani, Hironori Oshita, Kazunobu Ohya, Mami Takeoka, Jane Chanda Kabwe, Yoshiki Miyasaka, Hiromasa Ito, Noriko Yodoya, Hiroyuki Ohashi, Junko Maruyama, Ryuji Okamoto, Tomoji Mashimo, Kaoru Dohi, Yuhei Nishimura, Kazuo Maruyama, Masahiro Hirayama
Aims We investigated whether the disruption of C–C motif chemokine receptor (CCR) 2 may attenuate the development of pulmonary arterial hypertension (PAH) in any rat models with the reversal of the associated pro-inflammatory state and vascular dysfunction, and synergize with a conventional pulmonary vasodilator. Methods and results Using Ccr2(−/−) rats generated by CRISPR/Cas9, we investigated pulmonary
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Inflammation and heart failure: are we facing a 'hedgehog's dilemma'? Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-31 Stefano Ministrini,Giovanni G Camici
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Regulation of blood pressure by METTL3 via RUNX1b–eNOS pathway in endothelial cells in mice Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-12 Yanhong Zhang, Xiaoxiao Yang, Mei Lan, Ze Yuan, Shuai Li, Yangping Liu, Cha Han, Ding Ai, Yang Yang, Yi Zhu, Bochuan Li
Aims Endothelial cells regulate vascular tone to control the blood pressure (BP) by producing both relaxing and contracting factors. Previously, we identified methyltransferase-like 3 (METTL3), a primary N6-methyladenosine (m6A) methyltransferase, as a key player in alleviating endothelial atherogenic progression. However, its involvement in BP regulation remains unclear. Methods and results To evaluate
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Inflammageing, a targetable pathway for preventing cardiovascular diseases Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-12 Juan Francisco Aranda, Cristina M Ramírez, María Mittelbrunn
Inflammageing, characterized by persistent chronic inflammation in older adults, has emerged as a critical factor linked to age-related diseases, such as cardiovascular diseases (CVDs), metabolic disorders, and cognitive decline, which collectively contribute to the leading causes of death globally. Elevated levels of cytokines, chemokines, and other inflammatory mediators characterize inflammageing
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miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-08 Giorgia Senesi, Alessandra M Lodrini, Shafeeq Mohammed, Simone Mosole, Jesper Hjortnaes, Rogier J A Veltrop, Bela Kubat, Davide Ceresa, Sara Bolis, Andrea Raimondi, Tiziano Torre, Paolo Malatesta, Marie-José Goumans, Francesco Paneni, Giovanni G Camici, Lucio Barile, Carolina Balbi, Giuseppe Vassalli
Aims Cardiac fibrosis in response to injury leads to myocardial stiffness and heart failure. At the cellular level, fibrosis is triggered by the conversion of cardiac fibroblasts (CF) into extracellular matrix-producing myofibroblasts. miR-24-3p regulates this process in animal models. Here, we investigated whether miR-24-3p plays similar roles in human models. Methods and results Gain- and loss-of-function
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Temporal changes in mediation effects on cardiovascular and microvascular outcomes with glucagon-like peptide-1 receptor agonist therapy: a post-hoc analysis of the LEADER trial. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-05 Zi-Yang Peng,Yu-Hsuan Lee,Huang-Tz Ou,Shihchen Kuo
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Causal cardiovascular risk factors for dementia: insights from observational and genetic studies Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-05 Emilie Westerlin Kjeldsen, Ruth Frikke-Schmidt
The escalating prevalence of dementia worldwide necessitates preventive strategies to mitigate its extensive health, psychological, and social impacts. As the prevalence of dementia continues to rise, gaining insights into its risk factors and causes becomes paramount, given the absence of a definitive cure. Cardiovascular disease has emerged as a prominent player in the complex landscape of dementia
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Neuroimmune cross-talk in heart failure Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-05 Sabrina Montuoro, Francesco Gentile, Alberto Giannoni
Heart failure (HF) is characterized by autonomic nervous system (ANS) imbalance and low-grade chronic inflammation. The bidirectional relationship between the ANS and immune system (IS) is named ‘neuroimmune cross-talk’ (NICT) and is based on common signaling molecules, receptors, and pathways. NICT may be altered in HF, and neuroinflammation seems to be a main driver of HF progression. In HF, heightened
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Epitranscriptomic regulation of cardiac fibrosis via YTHDF1-dependent PIEZO2 mRNA m6A modification Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-05 Ji-Fei Ding, Bin Tu, Kai Song, Zhen-Yu Liu, Li-Chan Lin, Zhi-Yan Liu, Yan Shi, Jing-Jing Yang, Jian-Yuan Zhao, Hui Tao
Aims Mechanosensitive (MS) ion channels play a key role in heart development, physiology, and disease. However, little is known about the molecular mechanisms of the MS non-selective cationic channel Piezo family in cardiac fibrosis. Methods and results Mice were treated with ISO/Ang-II/TAC to induce cardiac fibrosis. AAV9 carrying POSTN promoter-driven small hairpin RNA targeting YTHDF1, and Piezo2
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PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-05 Haobin Zhou, Xiao Wang, Tianyu Xu, Daojing Gan, Zhuang Ma, Hao Zhang, Jian Zhang, Qingchun Zeng, Dingli Xu
Aims Sterile inflammation is implicated in the development of heart failure (HF). Mitochondria play important roles in triggering and maintaining inflammation. Mitophagy is important for regulation of mitochondrial quality and maintenance of cardiac function under pressure overload. The association of mitophagy with inflammation in HF is largely unclear. As PINK1 is a central mediator of mitophagy
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The history of science captured in paintings: what modern scientists can learn by studying the history of science? Cardiovasc. Res. (IF 10.2) Pub Date : 2024-11-05 Gerard Pasterkamp,Tomasz J Guzik
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Tackling change: menopause as a cardiovascular disease risk factor and the path to health equity. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-14 W Glen Pyle
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Minimizing gut microbiome confounding factors in cardiovascular research. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-04 Rikeish R Muralitharan,Jan W Buikema,Francine Z Marques
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Zebrafish arterial valve development occurs through direct differentiation of second heart field progenitors Cardiovasc. Res. (IF 10.2) Pub Date : 2024-10-26 Christopher J Derrick, Lorraine Eley, Ahlam Alqahtani, Deborah J Henderson, Bill Chaudhry
Aims Bicuspid aortic valve (BAV) is the most common congenital heart defect, affecting at least 2% of the population. The embryonic origins of BAV remain poorly understood, with few assays for validating patient variants, limiting the identification of causative genes for BAV. In both human and mouse, the left and right leaflets of the arterial valves arise from the outflow tract cushions, with interstitial
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Erbb3 and Hspa2, two novel predictors of heart failure in diabetic patients. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-04 Maurizio Forte,Mattia Galli,Sebastiano Sciarretta
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Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond Cardiovasc. Res. (IF 10.2) Pub Date : 2024-10-25 Qiuyu Sun, Qutuba G Karwi, Nathan Wong, Gary D Lopaschuk
The very high energy demand of the heart is primarily met by adenosine triphosphate (ATP) production from mitochondrial oxidative phosphorylation, with glycolysis providing a smaller amount of ATP production. This ATP production is markedly altered in heart failure, primarily due to a decrease in mitochondrial oxidative metabolism. Although an increase in glycolytic ATP production partly compensates
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Tumour necrosis factor receptor-associated factor 7: a new member of the E3 ligase family in cardiac hypertrophy. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-14 Chen Gao,Jinyun Zhu,Ningjing Song,Yibin Wang
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A hidden role of Th17 cells in doxorubicin-induced cardiac ferroptosis. Cardiovasc. Res. (IF 10.2) Pub Date : 2024-12-14 Yangfeng Hou,Wentao Gao,Kathy O Lui