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Low-fibre diet is associated with high-risk coronary plaque features Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-16 Ingrid Larsson, Jiangming Sun, Shafqat Ahmad, Göran Bergström, Carl-Johan Carlhäll, Kerstin Cederlund, Isabel Drake, Jan E Engvall, Mats Eriksson, Henrik Hagström, Tomas Jernberg, Tanja Kero, Krister Lindmark, Maria Mannila, Marju Orho-Melander, Araz Rawshani, Ulf Risérus, Annika Rosengren, Mats Ryberg, Caroline Schmidt, Emily Sonestedt, Maria Wennberg, Carl Johan Östgren, Isabel Goncalves
Aims Diet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features. Methods and results The cross-sectional population-based study using data from the Swedish CArdioPulmonary BioImage Study (SCAPIS) included 24 079 adults aged 50–64 years, recruited in
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Addressing obesity and subsequent cardiovascular risk in primary care: the relevance of high- and low-resource settings. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-13 Aletta E Schutte
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An activator of PI3Kα restores cardioprotection from ischaemia/reperfusion injury in mice with coronary atherosclerosis or insulin resistance Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-13 Pelin Golforoush, Elias Sulaiman, David He, Derek M Yellon, Sean M Davidson
Background In patients with coronary artery disease (CAD), morbidity and mortality from myocardial infarction remain high. Cardioprotective strategies such as Remote Ischaemic Conditioning (RIC) are highly effective in animal models but have disappointed in large clinical trials. One explanation may be that ischaemia and reperfusion (I/R) experiments are typically conducted in mice that lack CAD. Unlike
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CTRP7 as a molecular biomarker associating with responsiveness to pulmonary vasodilators: insights from human and animal studies in pulmonary arterial hypertension Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-12 Kaito Yamada, Taijyu Satoh, Nobuhiro Yaoita, Naoki Chiba, Yusuke Yamada, Kohei Komaru, Sho Onuma, Shigeo Godo, Saori Yamamoto, Haruka Sato, Takashi Nakata, Kotaro Nochioka, Hisashi Oishi, Satoshi Miyata, Yoshinori Okada, Satoshi Yasuda
Aims Pulmonary arterial hypertension (PAH) is a life-threatening condition. Although pulmonary vasodilators have shown promise in managing PAH, the improvement in prognosis is modest, partly because of a lack of biomarkers to guide their selection. Herein, we aimed to identify molecular-based predictors of responsiveness to pulmonary vasodilators using clinical and preclinical investigations. Methods
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C-C motif chemokine receptor 2 and phosphodiesterase type 5 inhibition in immune subphenotypes: a step toward personalized treatment for pulmonary arterial hypertension? Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-10 Christian J Goossen,Patrick J Pagano
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Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve (BAV) caused by loss of primary cilia Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-10 Ahlam Alqahtani, Lorraine Eley, Jake Newton, Kimberley Macdonald, Chloe Connolly, Cindy Rodrigues-Cleto, Kristyna Neffeova, Leonor Lopez, Javier Arias, Christopher J Derrick, Mashael Alaradi, Hana Kolesova, Bill Chaudhry, Deborah J Henderson
Aims Bicuspid aortic valve (BAV), where two valve leaflets are found instead of the usual three, affects 1-2% of the general population and is associated with significant morbidity and mortality. Despite its frequency, the majority of cases remain unexplained. This is, at least in part, because there are two types of valve leaflet primordia: endocardial cushions and intercalated valve swellings (ICVS)
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Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-10 Anuradha Kaistha, Sebnem Oc, Abel Martin Garrido, James C K Taylor, Maria Imaz, Matthew D Worssam, Anna Uryga, Mandy Grootaert, Kirsty Foote, Alison Finigan, Nichola Figg, Helle F Jørgensen, Martin Bennett
Aims Human atherosclerotic plaque cells display DNA damage that if left unrepaired can promote premature cell senescence. Vascular smooth muscle cells (VSMCs) predisposed to senescence promote atherogenesis and features of unstable plaques and increase neointima formation after injury. However, how premature VSMC senescence promotes vascular disease and its effects on VSMC phenotype are unknown. Methods
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Platelet-leukocyte aggregates in cardiovascular disease: prognostic significance and therapeutic potential Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-09 Jiaying Han, Conor J Bloxham, Kilian Kirmes, Giacomo Viggiani, Leonhard P Unkelbach, Moritz von Scheidt, Stephanie G Kühne, Isabell Bernlochner, Gianluigi Condorelli, Philip W J Raake, Dario Bongiovanni
Initially recognised for their role in vascular haemostasis, platelets are now understood to be critical regulators of inflammation and immune responses through complex interactions with immune cells. Key to this role is the formation of platelet-leukocyte aggregates (PLAs), with platelet-monocyte aggregates (PMAs) representing the most thoroughly studied type in cardiovascular disease. PLAs form through
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Mapping human brain topography to heart rhythms: an SEEG study Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-04 Xiaopeng Wang, Haoxun Yang, Yueyang Cheng, Shujia Liu, Guangyuan Jin, Zichen Qiao, Lei Qi, Siyi Wang, Junliang Ge, Dongmei Hu, Hai Tang, Runshi Gao, Cuiping Xu, Xiaohua Zhang, Di Wang, Xiangyu Xue, Anqi Dai, Wenbo Zhao, Tao Yu, Yuping Wang, Bailu Si, Guoguang Zhao, Liankun Ren
Aims The interplay between the heart and brain has been a subject of interest for centuries, as dysfunction in this interaction is implicated in various cardiovascular diseases and neurological disorders. Despite this advancement, there is currently a limited understanding of the mechanisms that the human brain communicates with heart rhythms. Here, we aim to characterize the human brain processing
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Cardiac regeneration beyond stem cells: harnessing sarcomere dynamics and endogenous repair mechanisms. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-03 Xiaoke Yin,Manuel Mayr
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Obesity and heart failure: exploring the cardiometabolic axis Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-03 Jennifer J Rayner, Ines Abdesselam, Jiliu Pan, Andrew J M Lewis, Oliver J Rider
Obesity is one of the biggest risks to public health in both developed and developing countries, and yet incidence continues to skyrocket. Being the main risk factor for a large number of life-limiting conditions, obesity has the potential to cause enormous damage unless addressed urgently. Heart failure (HF) is the most common cardiovascular disease associated with obesity. The incidence of HF overall
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A rare gain of function variant of hepatic lipase attenuates hypercholesterolemia and atherosclerosis in mice via an LDL receptor-independent mechanism Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-03 Thibaud Sotin, Xiaoke Ge, Milena Schönke, Lucie Vince, Amélie Thouzeau, Samuel Frey, Victoria Lorant, Lisa Krul, Amanda C M Pronk, Reshma Lalai, Trea C M Streefland, Salwa Afkir, Wieneke Dijk, Sarra Smati, Marieke Heijink, Niek Blomberg, Martin Giera, Mathilde Di Filippo, Philippe Moulin, Sander Kooijman, Bertrand Cariou, Patrick C N Rensen, Cédric Le May
Aims LIPC encodes hepatic lipase (HL), a liver-bound protein with both phospholipase and triglyceride lipase activity, and involved in the catabolism of circulating lipoproteins. We recently identified the gain-of-function variant HL-E97G, with selectively increased phospholipase activity, as a new genetic cause of familial combined hypocholesterolemia in humans. The role of HL in the development of
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Platelets and inflammation - insights from platelet non-coding RNA content and release in the Bruneck Study and the PACMAN-AMI trial Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-03 Clemens Gutmann, Temo Barwari, Christian Schulte, Konstantinos Theofilatos, Bhawana Singh, Kaloyan Takov, Gonca Suna, Melissa V Chan, Paul C Armstrong, Christian Cassel, Yasushi Ueki, Jonas D Häner, Peter Santer, Peter Willeit, Christian Hengstenberg, Lorenz Räber, Stefan Kiechl, Johann Willeit, Timothy D Warner, Manuel Mayr
Aims Platelets contain non-coding RNAs (ncRNAs), and their measurement may complement platelet aggregometry. Methods and results In the community-based Bruneck Study (n = 338), we generated platelet-rich plasma (PRP), platelet-poor plasma (PPP) and platelets. PRP was subjected to aggregometry using various agonists and processed to platelet releasates thereafter. Releasates, PPP and platelets underwent
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Single-cell epigenomic and transcriptomic analysis unveils the pivotal role of GATA5/ISL1+ fibroblasts in cardiac repair post-myocardial infarction Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-03 Shuchen Zhang, Boyang Xiang, Yiheng Zhao, Wenjing Wang, Lili Chen, Xiang Zhou
Aims A comprehensive understanding of the genome-wide regulatory landscape of the cardiac tissues post-myocardial infarction (MI) is still lacking. We therefore integrated single-cell RNA sequencing (scRNA-seq) and single-cell for transposase-accessible chromatin sequencing (scATAC-seq) to elucidate the epigenetic landscape of the heart post-MI. Methods and results We established MI mice through ligation
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Ceramides in cardiovascular disease – emerging role as independent risk predictors and novel therapeutic targets Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-03 Roland Klingenberg, Andreas Leiherer, Dobromir Dobrev, Juan C Kaski, Bodo Levkau, Winfried März, Samuel Sossalla, Arnold von Eckardstein, Heinz Drexel
Ceramides are bioactive lipid mediators involved in apoptosis, inflammation, and fibrosis. This narrative review provides a concise overview of the emerging role of ceramides in cardiovascular disease with emphasis on atherosclerotic vascular disease and heart failure, suggesting a potential use of ceramides in risk stratification and as putative therapeutic targets. Recent developments based on observational
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Adverse cardiac events associated with antibody drug conjugates in cancer patients: a retrospective analysis on the FAERS database and randomized controlled trials Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-02 Shaowei Zhuang, Bitao Wang, Enmin Wu, Jierong Lin, Wanxian Zeng, Maobai Liu, Jing Yang, Xiujuan Zhang
Aims Antibody Drug Conjugates(ADCs) are approved for use in cancers. Cardiovascular adverse reaction is a fatal adverse reactions associated with ADCs. The incidence of adverse cardiac events about ADCs have not been fully studied. We aimed to assess differences in cardiotoxicity among cancer patients treated with different ADCs. Methods and Results An observational retrospective pharmacovigilance
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Targeting CD8+ T cells in cardiovascular diseases - current options and therapeutic perspectives Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-31 Rida Al-Rifai, Vincent Duval, Icia Santos-Zas, Théo Guyon, Luna Chetrit, Corinne Tanchot, Clement Cochain, Alma Zernecke, Marc Vocanson, Benoit Bensaid, Alain Tedgui, Heinz-Peter Schultheiss, Christian Baumeier, Christian Bailly, Hafid Ait-Oufella
T lymphocytes expressing the CD8 coreceptor, often referred to as cytotoxic T-lymphocytes (CTL), are critical in defending against virus infections and cancers. CD8 encompasses a diverse family of proteins, including homodimers, heterodimers, isoforms, and splice variants. CD8αβ heterodimers are the predominant form of the CD8 membrane protein, often anchored to lipid rafts to facilitate the activation
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Sweeteners: erythritol, xylitol and cardiovascular risk - friend or foe? Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-30 Bettina K Wölnerhanssen, Anne Christin Meyer-Gerspach, Arduino Arduini, Angelo D’Alessandro, Edoardo Gronda, Stefano Carugo, Mario Bonomini, Maurizio Gallieni, Valentina Masola, Anne Angelillo-Scherrer, Tommaso Prosdocimi, Gary D Lopaschuk
Hyperglycemia harms vascular health and promotes platelet aggregation. Reducing glucose concentration is crucial, and sugar alcohols may aid this effort. Used for over 50 years in food, cosmetic, and pharmaceutical industries, erythritol and xylitol minimally affect plasma glucose and insulin levels while promoting the release of beneficial gastrointestinal hormones such as e.g. glucagon-like peptide-1
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PRDM16, a new kid on the block in cardiovascular health and disease Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-29 Jore Van Wauwe, Hannelore Kemps, Pieter Vrancaert, Alexia Mahy, Robin Schellingen, Mandy O J Grootaert, Manu Beerens, Aernout Luttun
Transcriptional regulation is essential for the development, homeostasis, and function of all organisms. Transcription factors and epigenetic modifiers play an indispensable role by direct or indirect interaction with DNA or chromatin. Although the role of transcription factor PRDM16 in adipose, hematopoietic, skeletal, and neural cell lineage specification is well-documented, its function within the
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Decoding calcific aortic valve disease: is liver X receptor the key to lipid metabolism? Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-12 Adrien Lupieri,Elena Aikawa
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Atrial fibrillation: a measure from one circular RNA. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-19 Francesco Ruberto,Roger Foo
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Novel roles of Nrf3-Trim5 axis in vascular smooth muscle cell dysfunctions and neointimal hyperplasia Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-16 Qishan Chen, Shasha Sun, Zhenning Shi, Leyu Wang, Yumeng Wang, Ancheng Zheng, Xiaolei Xu, Mei Yang, Kun Sun, Qingzhong Xiao, Li Zhang
Aims Neointimal hyperplasia (NIH) characterized by vascular smooth muscle cell (VSMC) dysfunctions plays a critical role in many vascular diseases including atherosclerosis and restenosis, which leads to serious ischemic complications and has limited therapeutic approaches. Our previous studies confirm a critical role for nuclear factor erythroid 2-related factor 3 (Nrf3) in VSMC differentiation. However
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Deficiency of NPR-C triggers high salt-induced thoracic aortic dissection by impairing mitochondrial homeostasis Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-15 Jin-Qiu Wei, Yi Yang, Wen-Hui Zhai, Jia-Jia Zhao, Yi-Hang Yang, Yuan-Yuan Kang, Qi-Fang Huang, Wei Zhang, Wu-Wei Rong, Qian-Wan Deng, Jing Chen, Xiao-Fei Ye, Ping-Jin Gao, Zhe Wang, Xiao-Dong Li, Ji-Guang Wang
Aims Thoracic aortic dissection (TAD) is a highly fatal disease lacking effective pharmacologic interventions in clinical practice. Emerging evidence indicates that the natriuretic peptide receptor C (NPR-C) plays a crucial role in the regulation of cardiovascular diseases. However, the precise involvement of NPR-C in TAD remains elusive. In this study, the role and molecular mechanisms of NPR-C in
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The Beating Heart: art meets science in the story of the heart. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-14 Robin P Choudhury
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Endothelial IGF-1 signaling: a conductor of vascular barrier function and LDL trafficking in atherogenesis. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-13 Cong Liu,Joanna M Kalucka
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Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-12 Kaylin C A Palm, Xiaoke Yin, Ferheen Baig, Konstantinos Theofilatos, Sander W van der Laan, Gert J de Borst, Dominique P V de Kleijn, Johann Wojta, Stefan Stojkovic, Manuel Mayr, Hester M den Ruijter, Gerard Pasterkamp, Ernest Diez Benavente, Michal Mokry
Aims Molecular characterization of vulnerable atherosclerotic plaques often relies on transcriptomic data. However, RNA expression may not consistently align with protein expression. The proteomic landscape linked to plaque vulnerability is underexplored in human lesions. In this study, we analyzed a large mass spectrometry-based proteomics dataset from the plaque tissue of 320 patients to identify
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Living myocardial slices: walking the path towards standardization Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-12 Jort S A van der Geest, Teun P de Boer, Cesare M Terracciano, Thomas Thum, Andreas Dendorfer, Pieter A Doevendans, Linda W van Laake, Joost P G Sluijter, Vasco Sampaio-Pinto
Cardiovascular disease remains a persistent global health burden, underscoring the necessity for effective therapeutic strategies. Despite significant advances, the ability to mechanistically study human disease and predict clinical outcomes remains limited, especially in complex diseases such as heart failure. This limitation is evident through the continuous high attrition rates in drug development
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RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: A drug-target Mendelian randomization study Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-10 Eloi Gagnon, Dipender Gill, Jérôme Bourgault, Émilie Gobeil, Patricia L Mitchell, Arnaud Girard, Audrey Paulin, Christian Couture, Yohan Bossé, Sébastien Thériault, Patrick Mathieu, Marie-Claude Vohl, André Tchernof, Kausik K Ray, John J P Kastelein, Benoit J Arsenault
Aims RNA interference therapies targeting liver expression of the gene proprotein convertase subtilisin/kexin type 9 (PCSK9) lower low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) levels. As opposed to monoclonal antibodies, which neutralise PCSK9 circulating protein, their effect on atherosclerotic cardiovascular disease (ASCVD) outcomes is unknown. We used genetic variants
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Atrial remodelling and atrial fibrillation self-sustaining: the role of circulating circDGCR8 Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-08 Yuanfeng Gao, Ying Dong, Nan Jiang, Hanrui Zhang, Zheng Liu, Qianhui Wang, Yuan Fu, Jing Li, Zhiqing Li, Huize Pan, Xianing Zheng, Lingyu Zhan, Xinchun Yang, Li Xu, Mulei Chen
Aims The prediction of atrial fibrillation (AF) progression and post-ablation recurrence is currently based on empirical estimates, leading to suboptimal predictive accuracy. This study investigates whether atrial remodelling, a key factor in the severity of atrial cardiomyopathy, could serve as a shared substrate influencing both AF progression and recurrence. We aimed to identify circular RNAs (circRNAs)
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Harnessing the power of the brain to fight metabolic diseases. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-23 Emiel P C van der Vorst,Giuseppe Lembo
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Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study - differences and similarities. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-06 Tove Fall,Anders Gummesson,Ulf Hammar,Håkan Ahlström,Oskar Angerås,Anders Blomberg,John Brandberg,Kenneth Caidahl,Elin Chorell,Jan E Engvall,Per Eriksson,David Erlinge,Bruna Gigante,Ola Hjelmgren,Johan Hultdin,Tomas Jernberg,Johan Kihlberg,Lars Lind,Martin Magnusson,Fredrik H Nyström,Carlo Pirazzi,Alexandru Schiopu,Johan Sundström,Stefan Söderberg,Carl Johan Östgren,Gunnar Engström
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The three calmodulin genes - territories defined? Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-02 Marcos Gonzalez,Quang-Kim Tran
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Abdominal aortic aneurysm histomorphology shows different inflammatory aspects among patients and is not associated with classic risk factors—the HistAAA study Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-29 Maja Carina Nackenhorst, Felix Menges, Bianca Bohmann, David Zschäpitz, Christine Bollwein, Sven Flemming, Nadja Sachs, Wolf Eilenberg, Christine Brostjan, Christoph Neumayer, Matthias Trenner, Wiebke Ibing, Hubert Schelzig, Christian Reeps, Lars Maegdefessel, Heinz Regele, Markus Udo Wagenhäuser, Claus Jürgen Scholz, Thomas Christian Gasser, Albert Busch
Aims Abdominal aortic aneurysm (AAA) treatment is upon a diameter threshold. Attempts for medical growth abrogation have failed thus far. This study aims to elucidate the heterogeneity of AAA histomorphology in correlation with individual patient and aneurysm metrics. Methods and results Samples from the left anterior aneurysm wall underwent histologic analysis including angiogenesis, calcification
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Distinct intracellular spatiotemporal expression of Calmodulin genes underlies functional diversity of CaM-dependent signaling in cardiac myocytes Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-24 Vladimir Bogdanov, Juan I E Mariangelo, Andrew M Soltisz, Galina Sakuta, Anastasia Pokrass, Casey Beard, Benjamin Hernandez Orengo, Roman Kalinin, Ali Ulker, Bennett Yunker, Svetlana Tikunova, Jenna Thuma, Xianyao Xu, Thomas J Hund, Rengasayee Veeraraghavan, Jonathan P Davis, Sandor Györke
Aims This study aims to resolve the mechanisms underlying Calmodulin (CaM)'s signaling diversity by investigating whether the three CaM genes—Calm1, Calm2, and Calm3—play distinct or redundant roles in cardiac myocytes, focusing on their spatial mRNA localization and interactions with key targets. Methods and Results We utilized single-molecule mRNA detection and 3D imaging to map the spatial distribution
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A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodeling Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-24 Feiya Li, William W Du, Xiangmin Li, Shuoyang Wen, Jindong Xu, Qiwei Yang, Jinfeng Wei, Sheng Wang, Nan Wu, Javeria Qadir, Burton B Yang
Aims Circular RNA circSLC8a1 has been previously suggested to possess translation potential, but experimental evidence supporting this notion has been lacking. We aim to understand the functions of circSLC8a1 and its translated protein in cardiac remodeling. Methods and Results To elucidate the functional significance of circSLC8a1, we established a transgenic mouse line expressing circSLC8a1 and its
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Identification of pulmonary artery stiffening due to left heart disease by ultrasonography Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-24 Mariya M Kucherenko, Marian Kukucka, Pengchao Sang, Niklas Hegemann, Qiuhua Li, Felix Hennig, Ruhi Yeter, Tara Gransar, Alexander Mladenow, Anna Emmerich, Andrea Orsenigo, Jana Grune, Volkmar Falk, Wolfgang M Kuebler, Christoph Knosalla
Aims Pulmonary hypertension (PH) is a common complication of left heart disease (LHD) that leads to right heart failure and death. Pulmonary artery (PA) stiffening has recently emerged as an important diagnostic and prognostic parameter in PH. The present study aimed to develop and validate an ultrasonographic index to identify PA stiffening in PH due to left heart disease (PH-LHD). Methods and Results
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Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-24 Lucilla Giammarino, Lluis Matas, Nicolò Alerni, András Horváth, Varjany Vashanthakumar, Saranda Nimani, Miriam Barbieri, Sahej Bains, Ruben Lopez, Julien Louradour, Balazs Ördög, Thomas Hof, Ange Maguy, Giulio Conte, Angelo Auricchio, Ulrich Schotten, Katja E Odening
Aims Pronounced sex-differences are known in the incidence of atrial fibrillation (AF). In this study, we aimed to investigate the atrial electrophysiological properties that may underlie sex-differences in AF incidence in the younger population, focusing on IK1, a cardiac ion current important for action potential (AP) stability and triggered activity. Methods and Results We assessed sex-differences
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Unravelling inflammation: the critical role of ETS2 in macrophage activation and chronic disease. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-12 Soumaya Ben-Aicha,Gustavo Ramos
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Sleep protects the heart after myocardial infarction through a neuro-immune axis: time to implement healthy sleep for cardiovascular prevention? Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-23 Fabrizia Bonacina,Daniela Carnevale
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Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-18 Anne F Cayron, Sandrine Morel, Maral Azam, Julien Haemmerli, Tomohiro Aoki, Philippe Bijlenga, Eric Allémann, Brenda R Kwak
Aim Polycystic kidney disease (PKD) patients have a high intracranial aneurysms (IAs) incidence and risk of rupture. The mechanisms that make PKD patients more vulnerable to IA disease are still not completely understood. The PCK rat is a well-known PKD model and has been extensively used to study cyst development and kidney damage. Here, we used this rat model to study IA induction and vulnerability
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Integrated proteomics identifies troponin I isoform switch as a regulator of a sarcomere-metabolism axis during cardiac regeneration Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-18 Timothy J Aballo, Jiyoung Bae, Wyatt G Paltzer, Emily A Chapman, Andrew J Perciaccante, Melissa R Pergande, Rebecca J Salamon, Dakota J Nuttall, Morgan W Mann, Ying Ge, Ahmed I Mahmoud
Aims Adult mammalian cardiomyocytes have limited regenerative potential, and after myocardial infarction (MI), injured cardiac tissue is replaced with fibrotic scar. In contrast, the neonatal mouse heart possesses a regenerative capacity governed by cardiomyocyte proliferation; however, a metabolic switch from glycolysis to fatty acid oxidation during postnatal development results in loss of this regenerative
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Spinning the web of platelet tetraspanins under stress. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-12 Madhumita Chatterjee
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Revivifying research on relaxin receptor-targeted therapy for cardiovascular diseases. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-12 Xiao-Jun Du
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It is all c-RELative: a new perspective for a member of the nuclear factor kappa B family. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-23 Jonathan O'Connor Miranda,Anthony Parent,Stephanie Lehoux
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Combined circulating microRNA and peptide biomarkers for prognostication in heart failure. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-17 Lee Lee Wong,Hiromi W L Koh,Hyungwon Choi,Ruiyang Zou,Lihan Zhou,Jia Yuen Lim,Dominic C Y Phua,Oi Wah Liew,Jenny P C Chong,Jessica Y X Ng,Siew Pang Chan,Yei-Tsung Chen,Poh Shuan D Yeo,Lieng H Ling,David Sim,Kui Toh G Leong,Hean Y Ong,Fazlur Jaufeerally,Raymond Wong,Ping Chai,Adrian F Low,Mayanna Lund,Gerry Devlin,Richard Troughton,Robert N Doughty,Carolyn S P Lam,Heng Phon Too,Arthur Mark Richards
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Tiny trouble: microplastics, nanoplastics, and their heartfelt impact on cardiovascular health Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-17 Tongyao Zhang, Yajie Liao, Jitao Ling, Jing Zhang, Deju Zhang, Xiaoping Yin, Peng Yu, Xiao Liu
Microplastics and nanoplastics are ubiquitous environmental pollutants that pose significant health risks. Several studies have reported the presence of these particles in various human tissues, including the heart, arterial plaques, and bloodstream of patients undergoing percutaneous coronary interventions. Emerging research suggests an association between these particles and an increased risk of
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Loss of MRAP2 in MC4R neurons protect from obesity-associated autonomic and cardiovascular dysfunctions Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-17 Deng Fu Guo, Paul A Williams, Alexis Olson, Donald A Morgan, Hussein Herz, Jon Resch, Deniz Atasoy, Harald M Stauss, Julien A Sebag, Kamal Rahmouni
Aims The melanocortin receptor accessory protein 2 (MRAP2), which is abundantly expressed in the brain including the hypothalamus, has emerged as a key regulator of melanocortin-4 receptor (MC4R) activity. We sought to delineate the physiological significance of MRAP2 in MC4R neurons, with a particular focus on autonomic and cardiovascular functions. Methods and Results Selective deletion of MRAP2
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The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-16 Carolina Janssen-Telders, Etto C Eringa, Joris R de Groot, Frances S de Man, M Louis Handoko
Heart failure with preserved ejection fraction (HFpEF) is a growing global health problem characterized by high morbidity and mortality, with limited effective therapies available. Obesity significantly influences haemodynamic and structural changes in the myocardium and vasculature, primarily through the accumulation and action of visceral adipose tissue. Particularly, epicardial adipose tissue (EAT)
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Beta 2 adrenergic receptor gene methylation activates innate lymphoid cells to drive hypertension in lymphocyte deficient hosts Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-10 Wei Chen, Sara Perrotta, Liang Xiao, Lorenzo Carnevale, Marwa A Abd-ElDayem, Elizabeth M Hennen, Luis Miguel Rivera-Medina, David M Patrick, Mingfang Ao, Fabio Pallante, Azzurra Zonfrilli, Shilin Zhao, Agnese Migliaccio, Lan Lan, Stefania Fardella, Giuseppe Sciumè, Francesco Mastroiacovo, Giuseppe Lembo, Daniela Carnevale, David G Harrison
Aims T cells contribute to hypertension; however, hypertension occurs in settings of T cell deficiency. Methods and results We studied two colonies of T/B cell-deficient RAG-1−/− mice with disparate responses to angiotensin II, being one protected from blood pressure increase and the other one responsive. This difference depends on the capability of hypertensive RAG-1−/− mice to expand natural killer
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Mimicked immunity: a strategy for targeted nanodrug delivery. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-23 Yapei Zhang,Charles C Hong,Bryan Ronain Smith
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Beat strong, think fast: how brain and heart keep each other in check. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-08 Daniela Carnevale,Costantino Iadecola,Joanna Wardlaw
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Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-04 João P Monteiro, Diptarka Saha, Ana-Mishel Spiroski, Saiba Mahesh, Peter Kaltzis, Abhijit Nadavallil, Vaibhao Janbandhu, Nicholas J Murray, Francesco Severi, Azzurra Laura De Pace, Sandra Sánchez-Esteban, Julie Rodor, Abdelaziz Beqqali, Matthew Bennett, Kevin Stewart, Adrian Thomson, Patrick W F Hadoke, Dyana Markose, John R Wilson-Kanamori, Neil C Henderson, Dónal O’Carroll, Thomas Quertermous, Richard
Aims The highly conserved long non-coding RNA (lncRNA) MIR505HG has been primarily recognized as a precursor for microRNAs (miR)-424 and miR-503. However, studies have since demonstrated that MIR503HG has distinct functions from its associated miRNAs, playing important roles in cell proliferation, invasion, apoptosis, and differentiation. While these miRNAs are known to influence cardiomyocyte differentiation
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Keep your guard up: blood-brain barrier protection by empagliflozin after acute ischaemic stroke. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-23 Karin Hochrainer,Ashley Hansen,Lidia Garcia-Bonilla
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Pre-ischaemic empagliflozin treatment attenuates blood–brain barrier disruption via β-catenin mediated protection of cerebral endothelial cells Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-02 Guohao Liu, Yanmei Qiu, Nanlin You, Mengchen Yu, Wenbo Chen, Tao Sun, Zhen Qin, Mengtao Han, Zhiwei Xue, Xiangjun Liang, Bo Mao, Lu Ling, Yanzhao Wu, Wenchen Xing, Quanmeng Liu, Donghai Wang
Aims Microvascular endothelial cells dysfunction can significantly worsen ischaemic stroke outcomes by disrupting tight junctions and increasing the acquisition of adhesion molecules, accelerating blood–brain barrier (BBB) disruption and pro-inflammatory response. The identification of drugs that improve endothelial cell function may be crucial for ischaemic stroke. It has been validated that empagliflozin
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Endothelial insulin-like growth factor-1 signaling regulates vascular barrier function and atherogenesis Cardiovasc. Res. (IF 10.2) Pub Date : 2025-04-01 Michael Drozd, Alexander-Francisco Bruns, Nadira Y Yuldasheva, Azhar Maqbool, Hema Viswambharan, Anna Skromna, Natallia Makava, Chew W Cheng, Piruthivi Sukumar, Lauren Eades, Andrew M N Walker, Kathryn J Griffin, Stacey Galloway, Nicole T Watt, Natalie Haywood, Victoria Palin, Nele Warmke, Helen Imrie, Katherine Bridge, David J Beech, Stephen B Wheatcroft, Mark T Kearney, Richard M Cubbon
Aims Progressive deposition of cholesterol in the arterial wall characterizes atherosclerosis, which underpins most cases of myocardial infarction and stroke. Insulin-like growth factor-1 (IGF-1) is a hormone that regulates systemic growth and metabolism and possesses anti-atherosclerotic properties. We asked whether endothelial-restricted augmentation of IGF-1 signaling is sufficient to suppress atherogenesis
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Tetraspanin CD37 regulates platelet hyperreactivity and thrombosis Cardiovasc. Res. (IF 10.2) Pub Date : 2025-03-29 Marcin A Sowa, Carmen Hannemann, Ivan Pinos Cabezas, Elissa Ferreira, Bharti Biwas, Min Dai, Emma M Corr, Macintosh G Cornwell, Kamelia Drenkova, Angela H Lee, Tanya Spruill, Harmony R Reynolds, Judith Hochman, Kelly V Ruggles, Robert A Campbell, Coen van Solingen, Mark D Wright, Kathryn J Moore, Jeffrey S Berger, Tessa J Barrett
Aim To investigate how psychosocial stress contributes to accelerated thrombosis, focusing on platelet activation and hyperreactivity. The specific objective was to identify novel platelet regulators involved in stress-mediated thrombosis, with a particular emphasis on the tetraspanin CD37. Methods and Results To explore how stress contributes to platelet hyperreactivity, platelets were isolated from
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A paradigm shift in cardiovascular research: new method isolates intestinal interstitial fluid to understand gut microbiome and host cross-talk. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-23 Fadi J Charchar,Francine Z Marques
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It takes more than omics to identify a cardioprotective mechanism. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-12 Gerd Heusch,Petra Kleinbongard
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Beneficial effects of vascular endothelial growth factor B gene transfer in the aged heart Cardiovasc. Res. (IF 10.2) Pub Date : 2025-03-23 Nivethitha Manickam, Ibrahim Sultan, Josefine Panthel, Haris Kujundzic, Ariane Fischer, Katja Schmitz, Mariano Ruz Jurado, David Rodriguez Morales, David John, Simone-Franziska Glaser, Kathrin A Stilz, Pedro Felipe Malacarne, Ralf Peter Brandes, Thomas Braun, Carolin Lerchenmüller, Fynn Betge, Wesley T Abplanalp, Kari Alitalo, Stefanie Dimmeler, Julian U G Wagner
Aim Members of the VEGF family are crucial modulators of vascular and neural function. While VEGFA signaling has been shown to mitigate several aging-related cardiac phenotypes and prolong survival in aged mice, the role of VEGFB in cardiac aging remains underexplored. In this study, we identify a significant decline in Vegfb expression, particularly of its soluble isoform Vegfb186, in aged mouse and
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From mice to humans: advancing the path to cardioprotection. Cardiovasc. Res. (IF 10.2) Pub Date : 2025-05-23 Lina Badimon,Gemma Vilahur,Guiomar Mendieta