OBJECTIVES This study aimed to evaluate the effectiveness, stability, and influencing factors of femtosecond laser-assisted arcuate keratotomy (FSAK) performed during cataract surgery for correcting corneal astigmatism (CA). METHOD A systematic literature review was conducted to identify clinical trials adopting a pre-post study design. Data sources included electronic databases such as PubMed, Scopus

PURPOSE Eye injuries are a leading cause of monocular vision impairment and disability in children and adolescents. Unlike adults, eye injuries in children exhibit significant age specificity, with worse visual outcomes due to immature vision, the risk of long-term damage, and amblyopia. However, research on the global distribution and trends of eye injury burdens in this population is limited. DESIGN

PURPOSE To report the efficacy and safety of scleral-suture fixation of intraocular lens (SFIOL) in children with nontraumatic ectopia lentis (EL) in a real-world setting. DESIGN Retrospective case series. METHODS The retrospective study included 220 eyes of 123 children with nontraumatic EL completing a minimum of 3 years postoperative follow-up, and was conducted at the Zhongshan Ophthalmic Center

PURPOSE To determine the impact of progression of central visual field (VF) and global VF on vision-related quality of life (VRQOL). DESIGN Retrospective cohort study. METHODS This study included 364 eyes of 235 primary open-angle glaucoma (POAG) participants who had at least five 24-2 VF tests over a minimum of 2-year follow-up. The slopes of global mean deviation (MD) and central mean total deviation

PURPOSE To describe the natural history of optical coherence tomography (OCT) and mesopic microperimetry (MP) parameters in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN Multi-center, international, prospective, longitudinal natural history study. METHODS STUDY POPULATION: 105 participants with biallelic disease-causing variants in USH2A with a clinical diagnosis

OBJECTIVE To assess the relationship between cataract surgery and the 30-day incidence of post-operative endophthalmitis (POE) (analysis 1) and serious systemic adverse events (analysis 2) in diabetic patients with varying preoperative hemoglobin A1c (HbA1c) levels. DESIGN Retrospective, longitudinal cohort study; multicenter study using a global federated database of electronic health records. SUBJECTS

PURPOSE This study aimed to investigate histological changes of trabecular meshwork (TM) in normal tension glaucoma (NTG) and determine whether trabeculectomy (TRAB) specimens from NTG patients can serve as normal controls for analyzing other types of high-tension glaucoma using TM analysis software (TMAS) based on light microscopy (LM). DESIGN Prospective comparative case series METHODS: TRAB specimens

PURPOSE To analyse the clinical characteristics, natural history and genetics of Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy (LCA / EOSRD) associated with uncommon genes. DESIGN Single tertiary referral centre retrospective case series. METHODS Review of clinical notes, ophthalmic images, and genetic testing results of 19 patients with disease-causing variants in genes which represent

OBJECTIVE To evaluate the post-marketing ocular adverse events (AEs) associated with avacincaptad pegol and pegcetacoplan, the only Food and Drug Administration (FDA)-approved treatments for geographic atrophy (GA). DESIGN Retrospective cohort study (pharmacovigilance analysis). SUBJECTS AE reports in the FDA Adverse Event Reporting System (FAERS) in which pegcetacoplan or avacincaptad pegol were identified

PURPOSE To develop imaging and consensus-based guidelines on the application of multimodal imaging in noninfectious multifocal choroiditis and panuveitis (MFCPU) and punctate inner choroiditis (PIC). DESIGN Consensus agreement guided by the review of literature and an expert committee using nominal group technique (NGT). METHODS An expert committee applied a timed structured nominal group technique

PURPOSE To investigate the success of strabismus surgery in older adults and determine the impact of age and underlying etiology on surgical outcomes. METHODS Retrospective review of medical records of patients aged 60 years or older who underwent strabismus surgery at a tertiary eye care center. Surgical motor and sensory outcomes were analyzed. RESULTS Of the 562 that met criteria, patients were

PURPOSE To compare the visual outcomes of two extended depth-of-focus (EDOF) intraocular lenses (IOLs). DESIGN Single-center prospective randomized controlled trial. METHODS Patients undergoing bilateral cataract surgery were randomly assigned to receive either the Acunex Vario IOL (Teleon Surgical B.V., Spankeren, The Netherlands) or the AcrySof IQ Vivity IOL (Alcon, Geneva, Switzerland); both Vario-

PURPOSE Choroidal neovascularization caused by age-related macular degeneration, among other diseases, causes significant visual impairment. Intravitreal therapeutics inhibiting vascular endothelial growth factor (VEGF) signaling have shown excellent safety and efficacy in regressing choroidal neovascularization and improving vision. Current FDA-approved treatments deliver these drugs into the vitreous

PURPOSE To report 12-month results from the GALE open-label extension study (NCT04770545), evaluating up to 36 months of intravitreal pegcetacoplan treatment for geographic atrophy (GA) in age-related macular degeneration (AMD). DESIGN GALE is a prospective open-label extension study following the 24-month, sham-controlled, phase 3 OAKS (NCT03525613) and DERBY (NCT03525600) studies of pegcetacoplan

PURPOSE To compare surgical outcomes following penetrating keratoplasty (PK), Descemet stripping endothelial keratoplasty (DSEK), and Descemet membrane endothelial keratoplasty (DMEK) in patients with iridocorneal endothelial (ICE) syndrome. DESIGN Systematic review and meta-analysis on individual patient data (IPD). METHODS Pre-registration was performed in the PROSPERO database (registration number:

PURPOSE Chronic neuropathic ocular pain (NOP) can develop alongside chronic dry eye (DE) post-laser-assisted in-situ keratomileusis (LASIK), yet its specific characteristics remain poorly understood. This study aims to compare the clinical characteristics of patients who developed both DE and NOP after LASIK to those with only DE and to asymptomatic LASIK patients, to facilitate the diagnosis of NOP

PURPOSE To investigate the rate of structural and functional progression in different age groups of highly myopic glaucoma patients and identify risk factors associated with rate of change in functional parameters. DESIGN Retrospective clinical cohort study METHODS: This study included open-angle, normal-tension glaucoma (NTG) patients with high myopia who had been followed-up for at least 8 years

OBJECTIVE Reducing unnecessary retinopathy of prematurity (ROP) screenings in neonates is important for minimizing morbidity associated with such examinations including pain for the child, anxiety in parents, and conserving healthcare resources. The Seminal Canadian Recommendations for Evidence-Based Examination of Neonates for Retinopathy of Prematurity (SCREEN-ROP) guidelines recommend only screening

PURPOSE To evaluate and classify the magnetic resonance imaging (MRI) features of anomalous orbital structures (AOS) and correlate these findings with clinical manifestations. DESIGN Retrospective, observational case series. METHODS The detailed clinical data from 35 patients diagnosed with congenital restrictive strabismus and AOS were retrospectively reviewed between July 2010 and October 2024. All

PURPOSE Retinal vein occlusion (RVO) is the second most common cause of vision loss from retinal vascular disease. Clinical trials often lack adequate representation of minority groups, limiting the external validity and equity of trial results. We aimed to characterize the evolution of ethnoracial demographic reporting, changes in the racial & ethnic composition of RVO trial participants, and correlations

PURPOSE The aim of this study was to assess whether Vitamin D (Vit D) supplementation affects local disease progression, as well as systemic inflammation, collagen degradation, and oxidative stress in adolescents affected by Keratoconus (KC) and Vit D deficiency. DESIGN Prospective, interventional single-center study. SUBJECTS Forty patients (age range, 12.2-19.9) presenting with both KC and Vit D

PURPOSE To compare choroidal layer thickness beneath flat irregular pigment epithelial detachments (PEDs) between uncomplicated chronic central serous chorioretinopathy (uCSC) and CSC complicated by type 1 macular neovascularization (cCSC). DESIGN Retrospective cross-sectional study METHODS: This retrospective study included 94 treatment-naïve eyes (45 uCSC, 49 cCSC) with flat irregular PEDs. Using

PURPOSE To use community engaged research to understand barriers to eye care utilization and explore participant experiences with free glaucoma screenings through the Michigan Screening and Intervention for Glaucoma and eye Health through Telemedicine (MI-SIGHT) program. DESIGN Qualitative study Subjects, Participants, and/or Controls: Purposive sampling of 42 participants out of 254 total participants

Deep learning (DL) has been used in differentiating a range of ophthalmic conditions. We describe a model to distinguish among fundus photos of acquired optic disc swelling due to idiopathic intracranial hypertension (IIH), non-arteritic anterior ischemic optic neuropathy (NAION), and healthy eyes.

To evaluate the association between statin use and the risk of ocular hypertension (OHT) and open-angle glaucoma (OAG) among patients with hyperlipidemia across different racial and ethnic subgroups.

PURPOSE To study changes in ocular biometry and refraction in the largest cohort to date of astronauts who have experienced long-duration spaceflight on the International Space Station (ISS). DESIGN A prospective cohort study. PARTICIPANTS 29 astronauts. METHODS Preflight and postflight cycloplegic refraction and ocular biometry measurements were obtained from 56 eyes among 29 subjects. For each eye

To describe the ideal size of a laser iridotomy and to discuss its importance.

Corneal biomechanical properties are associated with axial elongation. We aimed to characterize corneal biomechanical properties in highly myopic eyes with myopic maculopathy (MM).

Neurotrophic keratopathy (NK) is a rare disease characterized by the loss of corneal innervation and increased vulnerability to injury. The diagnosis and treatment of NK can be challenging for pediatric patients and their caregivers. This study explores the experiences of caregivers navigating the diagnostic and treatment journey of pediatric patients with neurotrophic keratopathy.

To describe three cases of, and review the current knowledge regarding, malignant transformation of ocular melanocytoma (OM) to uveal melanoma (UM).

We sought to compare the accuracy of different corneal curvature parameters in estimating corneal power change in eyes that underwent myopic small-incision lenticule extraction (SMILE).

To investigate trends in acute central retinal artery occlusion (CRAO) diagnostic assessments and sociodemographic characteristics of patients in the United States (US) emergency department (ED).

To identify and analyze ocular features seen in Vacuoles, E1-ligase, X-linked Auto-inflammatory, Somatic (VEXAS) syndrome.

Corneal allogeneic intrastromal ring segments (CAIRS) are a novel therapeutic approach to treat ectatic diseases such as keratoconus and improve visual acuity as well as corneal topography. This analysis aimed to evaluate the visual outcomes and corneal topography changes after CAIRS implantation for keratoconus.

To objectively evaluate the alteration of interdigitation zone (IZ) length in diabetic patients and to determine its relationship with diabetic retinopathy (DR) progression.

To analyze the demographics, immunosuppressant use, associated systemic diseases, ocular comorbidities, and incidence and prevalence of uveitis and associated low vision using the United States TriNetX database from 2013-2023.

To report visual field loss using static perimetry (SP) and kinetic perimetry (KP) over 4 years in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study.

To review the clinical outcomes of patients with ocular syphilis that were treated in the short-term with intravitreal ceftazidime when definitive treatment with penicillin was delayed due to a variety of extenuating circumstances.

To determine the association among age, gestational age, glaucoma-related adverse events, and visual acuity following unilateral cataract surgery.

While povidone-iodine (PI) is a commonly used antiseptic solution for postinjection endophthalmitis (PIE) prophylaxis, chlorhexidine (CHX) may be better tolerated by patients. This systematic review and meta-analysis aims to comprehensively compare the efficacy and safety of CHX and PI for PIE prophylaxis.

To evaluate the safety and intraocular pressure (IOP)-lowering efficacy of the ocular pressure adjusting pump in subjects with normal-tension glaucoma (NTG).

To investigate and compare the characteristics of colour Doppler ultrasound (CDUS) and contrast-enhanced ultrasound (CEUS) in degenerative retinoschisis (RS) and rhegmatogenous retinal detachment (RD).

To determine the population-based sensitivities and specificities of various inflammatory markers for the diagnosis of GCA.

Telomere biology disorders (TBDs) are inherited conditions caused by telomere dysfunction, impacting systemic and ocular health. We aim to explore the role of optical coherence tomography angiography (OCTA) in identifying retinal microvascular abnormalities in TBDs.

To systematically review, synthesize and quantify studies reporting patterns of adherence and persistence with prostaglandin analogues (PGAs) in order to comprehensively understand real-world treatment behavior among patients with glaucoma who are prescribed PGAs. These data can inform the decision between a glaucoma therapy based on either topical PGA medications or procedural PGA-based intervention

Intraoperative floppy iris syndrome (IFIS) is associated with an increased rate of severe intraoperative complications and greater visual morbidity during cataract surgery, particularly in females. To date, no postmarketing pharmacovigilance study has comprehensively examined all FDA-approved drugs for their association with IFIS development or explored potential sex differences. Understanding the