Purpose Retinal drusen have been described in people with IgA nephropathy. We examined the frequency of drusen in IgA nephropathy, and compared their location and composition with those for drusen in age-related macular degeneration. Design Immunohistological case series of eyes of patients with IgA nephropathy, and a comparison eye with age-related macular degeneration. Methods Donor eyes from four

Purpose To develop deep learning (DL) models estimating the central visual field (VF) from optical coherence tomography angiography (OCTA) vessel density (VD) measurements. Design Development and validation of a Deep Learning model Methods A total of 105110-2 VF OCTA pairs from healthy, glaucoma suspects, and glaucoma eyes were included. DL models were trained on enface macula VD images from OCTA to

Purpose To assess factors that impact the risk of relapse in patients with non-infectious uveitis (NIU) who undergo adalimumab tapering after achieving remission. Design Retrospective study. Methods − Setting: Multicenter study. − Study Population: Patients with NIU treated with adalimumab and subsequently tapered. − Observation Procedure: Patient demographics, type of NIU, onset and duration of disease

Purpose To investigate the incidence and risk of non-infectious uveitis (NIU) following Coronavirus Disease 2019 (COVID-19) vaccination compared to an unvaccinated, uninfected control group. Design Retrospective population-based cohort study Methods We included 5,185,153 individuals who received the first vaccine dose in the exposed group and 2,680,164 individuals in the unexposed, uninfected control

Purpose To determine the association between ocular and facial demodicosis, and the effect of facial treatment on ocular demodicosis. Design Prospective clinical cohort study. Methods Ocular demodicosis outpatients from a tertiary medical center were enrolled from April to December 2020. The diagnosis was based on epilation of four eyelashes from each upper eyelid. High ocular Demodex load (ODL) was

Purpose To investigate the demographic and clinical characteristics of patients with sympathetic ophthalmia (SO) and define the risk factors for its incidence following trauma and ophthalmic procedures. Design Retrospective cohort study. Participants Patients in the American Academy of Ophthalmology's (Academy) IRIS® Registry (Intelligent Research in Sight) who were (n=1,523) or were not diagnosed

PURPOSE To systematically review the literature and quantitatively synthesize the currently available evidence to compare the accuracy of different intraocular lens calculation formulas in eyes with long axial length (AL). DESIGN Network meta-analysis. METHODS PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched for studies published between January 2000 and June 2022

Abstract not available

Purpose To assess longitudinal relationships among visual function and anatomical measures of gene therapy in G11778A Leber hereditary optic neuropathy (LHON). Design Phase 1 clinical trial. Methods Setting: single institution. Participants: Patients with G11778A LHON and chronic bilateral visual loss >12 months (Group 1,n=11), acute bilateral visual loss <12 months (Group 2,n=9), or unilateral visual

PURPOSE This study aimed to determine the threshold for defining abnormal retinal sensitivity (RS) that correlates with structural changes in diabetic macular ischemia (DMI) patients with stable treated proliferative diabetic retinopathy (PDR). DESIGN Prospective cross-sectional study. METHODS In a single center, we recruited 85 eyes (67 patients) with stable treated PDR with best-corrected visual

Purpose : To describe the association between visual field loss and frailty in a nationally representative cohort of U.S. adults. Design Retrospective cross-sectional study. Methods : The cohort included adults 40 years or older with complete eye examination data from the 2005-2006 and 2007-2008 National Health and Nutrition Examination Surveys (NHANES). Visual field loss (VFL) was determined by frequency

Abstract not available

Background It is unclear whether transient monocular vision loss (TMVL) warrants the same thorough systemic evaluation for potential embolic sources in young adults as it does in older adults. The objective of the present study was to evaluate the yield of investigations in patients under 45 years old presenting with TMVL. Design Prospective cohort study. Methods Young patients with TMVL presenting

Purpose The E-ROP study evaluated 1257 patients screened for retinopathy of prematurity (ROP) and found that no infant born at or after 27 weeks’ gestational age and having birth weight over 750g developed treatable disease if they had no ROP at 37 weeks’ gestational age. They suggested there is little value in continued screening of infants meeting these criteria who have no ROP at 37 weeks. We attempted

Purpose To investigate the effectiveness of a novel spectacle lens designed to slow the progression of myopia in children. Design A prospective, randomized, double blind clinical trial. Methods 126 Israeli children aged 6-13 with spherical equivalent (SER) refractive errors of -0.5 to -6.25 D, were randomized into either the Shamir Myopia Control (SMC) lens design group, or the conventional single-vision

Abstract not available

Purpose To investigate factors associated with the severity of prelaminar schisis (PLS) in heathy subjects and glaucoma patients. Design Prospective cross-sectional study Methods Two hundred seventeen eyes of 217 subjects (110 normal eyes and 107 open angle glaucoma eyes). Frequency and severity of PLS were compared between normal and glaucomatous eyes. Multivariate logistic models were used to assess

Purpose To describe baseline results of the Alabama Screening and Intervention for Glaucoma and eye Health through Telemedicine (AL-SIGHT) for patients at federally qualified health centers (FQHC's). Candidates were persons at-risk for glaucoma associated diseases (GAD) based on age, race/ethnicity, current diagnosis of GAD, family history, and diabetes. Design Baseline screening visit followed by

Purpose To define the external scleral sulcus (ESS) on a Scheimpflug image and use it for a morphometric analysis of corneal diameter (CD). Design Retrospective, cross-sectional study of pediatric Asian-Indian eyes. Methods One random eye of 353 subjects between 5 to 18 years underwent 25-scan Pentacam HR imaging. For all scans, densitometry values along the anterior corneal edge were recorded and

Purpose To determine the prevalence and magnitude of OCT exposed neural canal (ENC), externally oblique choroidal border tissue (EOCBT), and exposed scleral flange (ESF) regions in 362 non-highly myopic (spherical equivalent -6.00 to 5.75 diopters) eyes of 362 healthy subjects. Design Cross-sectional study Methods After OCT optic nerve head (ONH) imaging, Bruch's membrane opening (BMO), the anterior

Purpose To examine rates of stroke, myocardial infarction (MI), deep vein thrombosis (DVT), pulmonary embolism (PE), and death in patients after retinal vein occlusion (RVO) compared to controls. Design Retrospective cohort study. Methods An aggregated electronic health records research network, TriNetX (Cambridge, MA, USA), was used to identify patients with diagnosis of RVO and a control group of

Purpose To systematically review and report the rate of exudative progression over time in patients with non-exudative macular neovascularization (MNV) in age-related macular degeneration (AMD). Design Systematic review with prevalence meta-analyses and individual participant meta-analysis. Methods We searched 10 literature databases on March 26, 2023, for studies of consecutive patients with treatment-naïve

Purpose To assess the relationship between diabetic retinopathy (DR) and corneal sensitivity. Methods In this prospective study, 100 eyes of 50 patients from primarily underrepresented racial and ethnic backgrounds with DR underwent assessment of corneal sensitivity using a Cochet-Bonnet esthesiometer. Severity of DR was graded by a masked reading center. Corneal sensitivity was compared in eyes with

Purpose To estimate the risk of incidence of optic neuritis and identify the high-risk group among patients with fibromyalgia (FM) Design Population-based cohort study Methods A nationwide, population-based study was conducted using data from the Korean National Health Claims database from 2012 to 2021. This study included all the patients with FM from the entire South Korean population aged 20–79

Purpose To investigate longitudinal changes in the anterior segment (AS) using serial optical coherence tomography (OCT) images and determine impact of these changes on the anterior chamber angle (ACA) in eyes with primary angle closure disease (PACD) treated with laser peripheral iridotomy (LPI). Design Retrospective clinical cohort study. Methods This study included 103 patients with PACD who underwent

Purpose To compare the clinical features and visual outcomes in children and adults with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Design Retrospective comparative case series. Methods This retrospective study included 280 eyes of 140 patients (35 children and 105 adults) with SJS/TEN treated between 2010 and 2020. The primary outcome measures were the final best corrected

Abstract not available

PURPOSE To describe 1-year secondary outcomes in the Tube Versus Trabeculectomy IRIS® (Intelligent Registry In Sight) Registry Study (TVTIRIS), and to compare to the TVT randomized controlled trial (TVTRCT). DESIGN TVTIRIS was a retrospective cohort study. METHODS The 2013-2017 IRIS Registry was used to identify eyes that received a tube shunt (tube) or trabeculectomy after a previous trabeculectomy

PURPOSE To develop and validate a novel patient-reported outcome (PRO) measure to assess vision-related functioning in individuals with severe peripheral field loss (PFL). DESIGN Prospective outcome measure development/validation study. METHODS A 127-item questionnaire was developed based on a prior qualitative interview study. A total of 116 participants with severe PFL due to retinitis pigmentosa

Purpose : To evaluate the long-term rotational stability of capsular bag-fixated toric intraocular lenses (IOLs) in polypseudophakic eyes of patients who underwent duet procedure for reversible trifocality. Design : Retrospective interventional case series. Methods : We included 34 eyes of 20 patients who underwent duet procedure with implantation of a monofocal toric IOL (RayOne toric, Hoya XY1AT

PURPOSE To analyze the clinical outcome of amniotic membrane transplantation in patients with ocular Stevens–Johnson syndrome/toxic epidermal necrolysis at a major burn unit. DESIGN Retrospective, non-randomized interventional study. METHODS A retrospective chart review from April 2014 to January 2022 of 43 patients (85 eyes) at a burn center who underwent amniotic membrane transplantation (AMT) for

Purpose To estimate the prevalence of incidental retinal emboli and identify associated factors using a nationally representative sample of the US population. Design Cross-sectional study. Methods Setting: 2005-2008 National Health and Nutrition Examination Survey (NHANES) Study population: All adults aged ≥ 40 years Observation: Incidental retinal emboli were identified through retinal fundus photography

Purpose To evaluate the association between rates of choroidal microvasculature dropout (MvD) change, beta-zone parapapillary atrophy (β-PPA) area change, and visual field (VF) changes in primary open-angle glaucoma (POAG) eyes. Design Retrospective, observational cohort study Methods In a tertiary glaucoma clinic, we included 76 eyes from 58 POAG patients with and without localized MvD, who had at

Purpose To compare the efficacy and safety of 120°, 240°, and 360° goniotomy (GT) with or without phacoemulsification with intraocular lens implantation (PEI) for primary open-angle glaucoma (POAG). Design Multicenter, retrospective, comparative, non-randomized interventional study. Methods Patients diagnosed with POAG who underwent GT with or without PEI were included, and divided into six groups:

Purpose To investigate the hereditability of corneal tomographic and biomechanical parameters in keratoconus (KC). Design Prospective cohort study. Methods Setting: Qingdao Eye Hospital of Shandong First Medical University, Shandong, China. Study Population A total of 44 patients with KC and their biological parents (n = 88) were recruited as the study group. The control group consisted of 84 healthy

Purpose To investigate the gene mutations and relationship of clinical manifestation in a Chinese family with familial lattice corneal dystrophy (LCD). Design Single-family case-control study. Methods A family with familial LCD was recruited for this study. A total of 10 affected and 13 healthy family members participated in this research. Clinical features were examined by slit-lamp examination and

Purpose : To investigate attitudes, priorities, and behaviors of ophthalmologists in salary negotiations. Design : Cross-sectional study. Methods : A Qualtrics survey was disseminated to United States based practicing ophthalmologists between 11/1/2021 and 3/31/2022 and assessed attitudes, behaviors and priorities surrounding salary negotiation during the respondents’ first negotiation as a practicing

PURPOSE To identify risk factors for flat anterior chamber that required additional intervention in the postoperative period (90 days) after uncomplicated Baerveldt Glaucoma Implant (BGI) surgery. DESIGN Retrospective, matched case-control study. METHODS A total of 42 cases (eyes) that received BGI at Anne Bates Leach Eye Hospital between February 1, 2011, and January 1, 2019, and that developed flat

Abstract not available

Purpose To compare the efficacy and safety of femtosecond laser–assisted deep anterior lamellar keratoplasty (F-DALK) with those of manual-trephination deep anterior lamellar keratoplasty (M-DALK) in treating keratoconus. Design Systematic review and meta-analysis. Methods Through November 2022, we comprehensively searched PubMed, EMBASE, the Cochrane Library, and four Chinese databases. Studies that

PURPOSE To assess the role of static and dynamic ocular biometric parameters measured in the dark and light for predicting progression of primary angle closure suspect (PACS) to primary angle closure (PAC). DESIGN Retrospective cohort study using prospective randomized controlled trial data from untreated, control eyes. METHODS Zhongshan Angle Closure Prevention Trial subjects underwent anterior segment

PURPOSE To evaluate the functional and structural changes of the meibomian glands and ocular surface in immunoglobulin G4–related ophthalmic disease (IgG4-ROD) patients. DESIGN Cross-sectional, matched case-control comparison study. METHODS This study included 64 patients with biopsy-proven IgG4-ROD (aged 63.4 ± 12.2 years, 39 male) and 64 sex- and age-matched healthy controls. Patients were managed

PURPOSE To determine whether macular infarction measured as hyper-reflectivity of the middle and inner retinal layers predicts long-term visual acuity outcomes in participants with central retinal vein occlusion (CRVO) or hemi-retinal vein occlusion (HRVO). DESIGN Clinical cohort study using post hoc secondary analysis of phase 3 clinical trial data. METHODS This post hoc secondary analysis of the

Purpose Rehabilitative orbital decompression treats disfiguring exophthalmos in Graves’ orbitopathy (GO) patients. This study aimed to identify risk factors associated with the postoperative recurrence of proptosis after orbital decompression. Design Retrospective case-control study Methods This retrospective review included patients with GO who underwent rehabilitative orbital decompression for disfiguring

Abstract not available

Purpose To compare the effect of filtering surgery versus clear lens extraction in young patients with medically uncontrolled angle-closure glaucoma (ACG). Design Retrospective, non-randomized, comparative, interventional study. Methods We reviewed the medical charts of patients with the following scenarios: (1) age ≤ 40 years, (2) diagnosis of ACG without cataract, including primary angle-closure

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Purpose Non-surgical consecutive exotropia (NCX) occurs when an esotropia (ET) spontaneously converts to exotropia (XT) without surgical intervention. Although considered to occur in early onset accommodative esotropia with high hyperopia, consensus on causation is lacking. We report the clinical characteristics of NCX and assess response to conservative management. Design Retrospective, multi-centered

PURPOSE To determine the outcomes of intentionally suspending anti–vascular endothelial growth factor (anti-VEGF) injections in eyes with advanced neovascular age-related macular degeneration (nAMD). DESIGN Retrospective cohort study. METHODS The study sample comprised 93 patients with nAMD and best available Snellen visual acuity (VA) ≤20/400 in which anti-VEGF treatment was suspended by the treating

PURPOSE To evaluate the outcomes of microcatheter-assisted trabeculotomy (MAT) in childhood glaucoma (primary congenital glaucoma [PCG], juvenile open-angle glaucoma [JOAG], and secondary childhood glaucoma [SCG]) after failed glaucoma surgery. DESIGN Retrospective interventional case series. METHODS Patients with childhood glaucoma who underwent MAT after failed glaucoma surgery with at least 12 months

Abstract not available

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PURPOSE To determine if macular thickness maps (MTMs) are sufficient to guide management of eyes with exudative age-related macular degeneration (eAMD), we compared the ability to detect change using MTMs with the ability to detect change using the entire optical coherence tomography (OCT) scan in patients undergoing therapy. DESIGN Retrospective, comparative diagnostic analysis. METHODS Patients with

PURPOSE To examine the relationship between diabetic retinopathy (DR) and depression in the United States. DESIGN Retrospective, cross-sectional study. METHODS National Health and Nutrition Examination Survey (NHANES) participants between 2005 and 2008 (ages 40-85 years) were included. Prevalence of major depression among DR stages as determined by retinal imaging was estimated. Multivariable models

PURPOSE To describe 6 cases and review the current state of knowledge of eosinophilic angiocentric fibrosis (EAF) involving the orbit. DESIGN Retrospective clinicopathologic case series and review of the current literature Methods Clinical records and histopathologic data of orbit-involving EAF were gathered between 2004 and 2022 from a single academic institution. The patients’ presenting clinical

PURPOSE To develop an automated deep learning system for detecting the presence and location of disc hemorrhages in optic disc photographs. DESIGN Development and testing of a deep learning algorithm. METHODS Optic disc photos (597 images with at least 1 disc hemorrhage and 1075 images without any disc hemorrhage from 1562 eyes) from 5 institutions were classified by expert graders based on the presence

Purpose To summarize key findings from a Cochrane Review of the benefits and safety of antibiotic therapy compared with placebo (or vehicle) for acute bacterial conjunctivitis. Design Systematic review and meta-analysis. Methods We included placebo-controlled randomized controlled trials (RCTs) that compared topical antibiotics with placebo. We followed Cochrane methods for trial selection, data extraction

PURPOSE Insufficient representation of women and underrepresented in medicine (URiM) students remains a problem among the ophthalmology workforce. In the residency selection process, research productivity is an important factor. We aimed to determine the average research output listed by applicants and assess for differences by gender and race. DESIGN Retrospective cohort study METHODS All San Francisco

PURPOSE To assess the long-term outcomes of corneal collagen cross-linking according to the Dresden protocol (S-CXL) in progressive pediatric keratoconus (KC). DESIGN Retrospective, single-center noncomparative interventional study. METHODS Patients aged <18 years who underwent S-CXL from June 2007 to January 2011 in Humanitas Clinical and Research Center, Rozzano, Milan, Italy, and completed at least