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THYROID EYE DISEASE: PILOT STUDY COMPARISON BETWEEN PATIENTS IN UNITED STATES- BASED AND INDIA- BASED PRACTICES Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-12 Sathyadeepak Ramesh, Milind Naik, Alison Watson, Qiang Zhang, Ellen Peskin, James Sharpe, Kieran Alessi, Leslie Hyman
Thyroid eye disease (TED) phenotype varies by ethnicity/race and genetic/environmental factors. This study compared demographic and clinical characteristics of TED patients from the US and India. Observational pilot study 64 patients with TED ages ≥18 years old with active disease (onset of symptoms ≤18 months presenting clinical activity score (CAS) ≥4) were recruited between March and October 2021
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Reply to Comment on “Association between physical indicators and myopia in American adolescents: National Health and Nutrition Examination Survey 1999-2008” Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-12 Ninghong Chen, Yonghong Sheng, Guoping Wang, Jing Liu
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Influence of sutureless scleral fixation techniques with 3-piece IOLs on dislocation force Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-10 Johannes Zeilinger MD, Martin Kronschläger MD PhD MHBA, Andreas Schlatter MD, Manuel Ruiss MSc., Natascha Bayer MSc., Oliver Findl MD MBA
To compare four different secondary IOL fixation techniques regarding the least required force to dislocate a scleral fixated 3-piece IOL in human corneoscleral donor tissue (CST). Experimental Laboratory investigation The least required dislocation force (LRDF) of four different secondary IOL fixation techniques, namely the techniques using transscleral tunnels (TT, as described by Scharioth), glued
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Characteristics of Eyes with CRB1-associated EOSRD/LCA: Age-related changes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-10 Jad Ayash, Russell L. Woods, James D. Akula, Farrah Rajabi, Bilal K. AlWattar, Pablo Altschwager, Anne B. Fulton
To evaluate ocular and retinal features of -associated early onset severe retinal dystrophy/Leber congenital amaurosis (EOSRD/LCA) for age-related changes. Retrospective cohort study. Sixteen pediatric patients with biallelic EOSRD/LCA who had been followed for up to 18 years were reviewed. Results of comprehensive ophthalmic examinations—including visual acuity, refractive error, dark-adapted visual
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En Face and Volumetric Comparison of Hypertransmission Defects Evaluated by Cirrus and Spectralis Optical Coherence Tomography Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-09 Jiwon Baek, Maryam Ashrafkhorasani, Alireza Mahmoudi, Muneeswar Gupta Nittala, Giulia Corradetti, SriniVas R. Sadda
To evaluate and compare and 3-dimensional (D) properties of hypertransmission defects (HTDs) between different optical coherence tomography (OCT) devices using OCT volumes and reconstructed images. Comparative diagnostic evaluation study. Thirty eyes with dry age-related macular degeneration (AMD) that underwent dense OCT macular volume scans with both the Spectralis (97 B-scans/volume; 2,910 B-scans
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Incidence of Blepharoptosis Following Intravitreal Anti-Vascular Endothelial Growth Factor Injections Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-08 Andrew Y. Lee BS, Kyle Kovacs MD, Anton Orlin MD, Szilard Kiss, Donald J. D'Amico MD, Kira L. Segal MD, Gary J. Lelli Jr. MD, Kyle J. Godfrey MD
We aimed to determine the incidence of blepharoptosis following intravitreal anti-vascular endothelial growth factor (VEGF) injections and compare the rates of blepharoptosis between patients injected with an eyelid speculum and those injected without a speculum. Retrospective cohort study International Classification of Diseases (ICD-10) was used to identify patients with exudative age-related macular
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A comparison of chemodnervation to incisional surgery for acute, acquired, comitant esotropia: An international study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-04 Crystal S.Y. Cheung, Michael J. Wan, David Zurakowski, Sylvia Kodsi, Noha S. Ekdawi, Heather C. Russell, Shashikant Shetty, Alina V. Dumitrescu, Linda R. Dagi, Ankoor S. Shah, David G. Hunter
To compare the efficacy of botulinum toxin injections to strabismus surgery in children with acute, acquired, comitant esotropia (ACE), and to investigate factors predicting success. International, multi-center non-randomized comparative study Setting: Cloud-based survey. Study population: Children aged 2-17 years who underwent a single surgical intervention for ACE. Interventions: Botulinum toxin
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Diagnostic accuracy of artificial intelligence based automated diabetic retinopathy screening in real-world settings: a systematic review and meta-analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-02 Sanil Joseph, Jerrome Selvaraj, Iswarya Mani, Thandavarayan Kumaragurupari, Xianwen Shang, Poonam Mudgil, Thulasiraj Ravilla, Mingguang He
To evaluate the diagnostic accuracy of artificial intelligence (AI)-based automated diabetic retinopathy (DR) screening in real-world settings. Systematic review and meta-analysis We conducted a systematic review of relevant literature from January 2012 to August 2022 using databases including PubMed, Scopus and Web of Science. The quality of studies was evaluated using Quality Assessment for Diagnostic
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Gonioscopy-Assisted Transluminal Trabeculotomy Outcomes under Different Levels of Glaucoma Severity: a Multicenter, Comparative Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-03-01 Leopoldo Magacho, Cláudia Gomide Vilela de S. Franco, Eduardo Akio I, Ana Cláudia Alves Pereira, Bruno Teno, Francisco Lucena-Neto, Bruno M. Faria, Júlia Maggi Vieira, Marcos Pereira Vianello, Fábio N. Kanadani
To evaluate the outcomes of Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) under different levels of glaucoma severity. Retrospective, multicenter, before-and-after study. One eye from all POAG patients that underwent both Phaco-GATT or GATT stand-alone with 12 months of follow-up were included and divided according to glaucoma severity (mild – GI; moderate – GII and advanced – GIII) and the
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“Inner choroidal fibrosis: An optical coherence tomography biomarker of severity in chronic central serous chorioretinopathy” Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-28 Saarang Hansraj, Jay Chhablani, Umesh Chandra Behera, Ritesh Narula, Raja Narayanan, Niroj Kumar Sahoo
To describe a potential biomarker termed as inner choroidal fibrosis in cases of chronic central serous chorioretinopathy presenting to a tertiary referral center. Observational case series. Five eyes of four patients with chronic central serous chorioretinopathy, were noted to have a grey-white subretinal lesion in the macula, which was analyzed with multimodal imaging. It was seen that the lesions
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Risk of corneal graft rejection and vaccination: a matched case-control study from a United States integrated health care system Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-27 Jennifer H. Ku, Afshan A. Nanji, Julia E. Tubert, Cynthia Joe, Divya Srikumaran, Kevin L. Winthrop, Amanda E. Brunton, Ana Florea, Frederick Fraunfelder, Tsaiyu Tseng, Yi Luo
Data on vaccine-associated corneal transplant rejections are limited. We examined the association between graft rejection and vaccination. Matched case-control We used electronic health records to identify corneal transplant recipients between 01/2008 and 08/2022 at Kaiser Permanente Southern California. Cases were transplant recipients who experienced a graft rejection (outcome) during the study period
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Patterns and Disparities in Recorded Gonioscopy During Initial Glaucoma Evaluations in the United States Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-27 Lee Jun Hui, Yoo Kristy, Lung Khristina, Apolo Galo, Toy Brian, Sanvicente Carina, Xu Benjamin
To assess patterns in gonioscopy during initial glaucoma evaluations in the United States. Retrospective, case-control study. Patients undergoing initial glaucoma evaluation between 2009-2020 were identified in the Optum Clinformatics® DataMart. Initial evaluation was defined as: 1) glaucoma suspect, anatomical narrow angle (ANA), or primary/secondary glaucoma diagnosed by an ophthalmologist; 2) continuously
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Effect of a patient portal reminder message after no-show on appointment reattendance in ophthalmology: a randomized clinical trial Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Sarah Atta, Richard B. Brown, Lauren M. Wasser, Natasha Mayer, Julie Cassidy, Peggy J. Liu, Andrew M. Williams
To assess the efficacy of electronic health record (EHR) messaging for re-engaging patients with ophthalmology care after a missed appointment. Prospective, randomized clinical trial. The study setting was an academic ophthalmology department. The patient population comprised return patients age 18 years or older with an appointment “no show,” or missed appointment. Over two phases of recruitment,
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Corneal Guttae Alone Do Not Make A Diagnosis of Fuchs Endothelial Corneal Dystrophy Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Jayne S Weiss, Natalie A. Afshari
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Effects of deep optic nerve head structures on Bruch's membrane opening- minimum rim width and peripapillary retinal nerve fiber layer Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Mitsuki Kambayashi, Hitomi Saito, Makoto Araie, Nobuko Enomoto, Hiroshi Murata, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Aiko Iwase, Goji Tomita, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M Zangwill, Robert N Weinreb
To explore the effects of deep optic nerve head (ONH) structures on Bruch's membrane opening (BMO)-minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) in healthy eyes. Prospective cross-sectional study Two hundred five healthy eyes of 141 subjects (mean ± standard deviation of age and axial length (AXL): 46.9±10.0 years and 24.79±1.15 mm) were enrolled. Best fit multivariable
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Association of ocular manifestations of Marfan syndrome with cardiovascular complications Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Elaine M. Tran, Karen M. Wai, Andrea L. Kossler, Prithvi Mruthyunjaya, Ehsan Rahimy, Euna B. Koo
To evaluate associations between ocular manifestations of Marfan syndrome and cardiovascular complications. retrospective cohort study Setting: TriNetX Analytics platform, a federated health research network of aggregated deidentified electronic health record data of over 119 million patients. Study Population: Patients diagnosed with Marfan syndrome. Observation Procedure: Univariate logistic regression
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Ultra-Wide-Field Optical Coherence Tomography and Gaussian Curvature to Assess Macular and Paravascular Retinoschisis in High Myopia Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-23 Qing Zhao, Xinyu Zhao, Yan Luo, Zhikun Yang
To evaluate the severity and related factors of macular retinoschisis (MRS) and paravascular retinoschisis (PVRS) in high myopia (HM) using ultra-wide-field optical coherence tomography (UWF-OCT) and a novel Gaussian curvature (K). A cross-sectional study. Patients diagnosed with HM in Peking Union Medical College Hospital were recruited between January 2022 and November 2022. The presence and severity
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Comment on Large Language Models in Ophthalmology Scientific Writing: Ethical Considerations, Blurred Lines or Not at All?1 Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Dr Alexander James Cameron Jessup, Professor Minas Theodore Coroneo
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Clinical Course and Visual Outcomes of Papilledema in Pediatric Cerebral Venous Sinus Thrombosis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Jessica A. Sun, Tais Estrela, Ryan Gise
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Socioeconomic Disparities in Glaucoma Severity at Initial Diagnosis: A Nationwide EHR Cohort Analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Swarup S. Swaminathan, Felipe A. Medeiros
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Comparison of the biometric characteristics after long term implantation of iris-fixated phakic intraocular lens in explanted and non-explanted groups of eyes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-22 Luis Izquierdo, Fiorella Casanova Imken, Pablo Larco, Jose Chauca, Maria A. Henriquez
To evaluate and compare the biometric characteristics of the anterior chamber of a group of patients with significant endothelial cell loss (ECL) that required phakic IOL (pIOL) explantation and a group of patients who did not fulfill the explantation criteria related to corneal decompensation. Retrospective consecutive interventional case series The study included all consecutive patients implanted
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Drug Approval for the Treatment of Geographic Atrophy: How We Got Here and Where We Need to Go Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 Karl G Csaky, Jason ML Miller, Daniel F Martin, Mark W. Johnson
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Clinical Significance of Optic Disc Hemorrhage Size in Visual Field Progression in Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 Yoon Jeong, Eunoo Bak, Mirinae Jang, Ahnul Ha, Young In Shin, Min Gu Huh, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
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Omidenepag Isopropyl Versus Timolol in Patients With Glaucoma or Ocular Hypertension: Two Randomized Phase 3 Trials (SPECTRUM 4 and 3) Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 Jason Bacharach, Jacob W. Brubaker, David G. Evans, Fenghe Lu, Noriko Odani-Kawabata, Takaharu Yamabe, David L. Wirta
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Comment on “Large Language Models in Ophthalmology Scientific Writing: Ethical Considerations Blurred Lines or Not at All?” Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 Konradin Metze, Irene Lorand-Metze, Rosana C Morandin-Reis, João B Florindo
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Anterior chamber cholesterol crystals in stage 5C retinopathy of prematurity Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-21 Huanyu Liu, Jie Peng, Peiquan Zhao
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Association between sociodemographic factors and self-reported glaucoma in the National Health Interview Survey: a population-based analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-20 Jim Xie, Nikhil S. Patil, Marko M. Popovic, Peter J. Kertes, Rajeev H. Muni, Matthew B. Schlenker, Iqbal Ike K. Ahmed, Radha P. Kohly
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Incidence and Outcomes of Eye Trauma Associated with Recreative Use of Non-Powder Toy-Guns: a 12-years retrospective study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-17 Alexandre DENTEL, Etienne BOULANGER, Thibaut CHAPRON, Lucile SENICOURT, Florence METGE, Pascal DUREAU, Catherine VIGNAL-CLERMONT, Georges CAPUTO, Gilles C. MARTIN
Non-powder toy-guns (NPTG) are responsible for many ocular traumas. This study aims to detail the outcomes of these injuries, depending on the causative NPTG. Retrospective observational case series. Cases of NPTG-associated ocular trauma managed in a Parisian eye emergency department between August 1, 2010, and January 1, 2023, were reviewed. The date of trauma, causative NPTG, patient demographics
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Severe spontaneous tilt of scleral-fixated intraocular lenses Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-17 Jennifer M Enright, Boonkit Purt, Brent Bruck, Parth Shah, Emily Eton, Sina Rezaei, Stephen Armenti, Kishan G Patel, James Liu, Angela Verkade, Abdualrahman Hamad, Thomas J Wubben, Arsham Sheybani, David Crandall, Bradford L Tannen, Grant M Comer, Shahzad Mian, Nambi Nallasamy
To report and evaluate a multicenter series of 18 cases of severe, spontaneous IOL tilt involving the flanged intrascleral haptic fixation technique (FISHF). Clinical study with historical controls We report a cross-sectional study of 46 FISHF cases using the CT Lucia 602 IOL at a single academic center over a period of 24 weeks to determine the incidence of severe rotisserie-style rotational tilt
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A novel risk stratification-based immunomodulatory treatment strategy for Vogt-Koyanagi-Harada disease Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-16 Kehan Jin, Anyi Liang, Hang Song, Feiyue Xiao, Fei Gao, Xiaoxu Han, Meifen Zhang, Chan Zhao
To develop a more tailored immunomodulatory treatment (IMT) strategy based on a novel two-arm risk stratification system in Vogt-Koyanagi-Harada (VKH) patients. A retrospective clinical cohort study. 79 VKH patients in the acute stage were stratified into low (n = 58) and high-risk (n = 21) groups based on their exposure to risk factors. They were treated with oral glucocorticoids (GCs) plus pro re
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Ocular Neuromyotonia: Clinical features, Diagnosis and Outcomes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-16 Tia B. Bodi, Lindsay D. Klaehn, Andrea M Kramer, M. Tariq Bhatti, Michael C. Brodsky, Eric R. Eggenberger, Marie A. Di Nome, Jacqueline A. Leavitt, James A. Garrity, John J. Chen, Sasha A Mansukhani
: The purpose of this study was to describe the clinical features, management, outcomes, and diagnostic pitfalls in a large series of patients with ocular neuromyotonia. Retrospective cohort Patients diagnosed with ocular neuromyotonia from January 1, 2004 through January 1, 2023 seen at one of the three Mayo Clinic sites; Rochester, MN, Scottsdale, AZ, and Jacksonville, FL. We ascertained patients
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Genetics, Clinical Characteristics, and Natural History of PDE6B-Associated Retinal Dystrophy Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-15 Shaima Awadh Hashem, Michalis Georgiou, Yu Fujinami-Yokokawa, Yannik Laich, Malena Daich Varela, Thales A.C. de Guimaraes, Naser Ali, Omar A. Mahroo, Andrew R. Webster, Kaoru Fujinami, Michel Michaelides
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Binocular Home Treatment for Amblyopia: Gains Stable for One Year Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-14 Tamara Wygnanski-Jaffe, Avital Moshkovitz, Burton J. Kushner, Michael Belkin, Oren Yehezkel
To report the long-term outcomes of a non-inferiority randomized controlled trial (RCT) with a binocular eye-tracking-based home treatment (CureSight; NovaSight, Ltd, Airport City, Israel) in patients with amblyopia. Prospective, multicenter, non-randomized, long-term follow-up observational study of an RCT. Forty-three children 4 to < 9 years of age with anisometropic, small-angle strabismic, or mixed-mechanism
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Fetal Growth Restriction Leads to an Enlarged Cup-to-Disc Ratio in Adults Born at Full Term Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-14 Achim Fieß, Sandra Gißler, Eva Mildenberger, Esther M. Hoffmann, Panagiotis Laspas, Bernhard Stoffelns, Norbert Pfeiffer, Alica Hartmann, Alexander K. Schuster
This study explores associations between fetal growth restriction or excessive fetal growth, along with perinatal factors on the optic nerve head morphology in adulthood. Retrospective cohort study. This retrospective cohort study involved a prospective ophthalmological examination of individuals born at full term (with a gestational age of ≥37 weeks) from 1969 to 2002. Each participant underwent nonmydriatic
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Comment on: An eye on the brain: Adding insight to injury Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-14 ANDRZEJ GRZYBOWSKI
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Correlation Between Anterior Chamber Angle Status and Limbal Stem Cell Deficiency in Primary Angle-Closure Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-13 Jiewen Mao, Yujin Wang, Yuelan Gao, Shanshan Wan, Weiyan Jiang, Yumiao Pan, Yulin Yan, Yuyu cong, Xiaoshuo Shi, Linying Huang, Yanning Yang
To investigate the correlation between the opening and closing states of anterior chamber angle (ACA) and the density of limbal epithelial basal cells (LEBCs) in subjects with primary angle-closure glaucoma (PACG). Cross-sectional observational study. A total of 54 eyes of 29 patients diagnosed with PACG were included in the study. Fifty-four eyes from normal subjects were included as control. Automatic
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Prediction of Visual Field Progression with Baseline and Longitudinal Structural Measurements Using Deep Learning Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-12 Vahid Mohammadzadeh, Sean Wu, Sajad Besharati, Tyler Davis, Arvind Vepa, Esteban Morales, Kiumars Edalati, Mahshad Rafiee, Arthur Martinyan, David Zhang, Fabien Scalzo, Joseph Caprioli, Kouros Nouri-Mahdavi
Identifying glaucoma patients at high risk of progression based on widely available structural data is an unmet task in clinical practice. We test the hypothesis that baseline or serial structural measures can predict visual field (VF) progression with deep learning (DL). Development of a DL algorithm to predict VF progression. 3,079 eyes (1,765 patients) with various types of glaucoma and ≥5 VFs,
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Uveitis Risk After the First Dose of COVID-19 Vaccination Based on Uveitis History: Matched Cohort and Crossover Case Series Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-09 Hae Rang Kim, Sunyeup Kim, Myung Soo Chang, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim
To investigate the risk of noninfectious uveitis following the first dose of coronavirus disease 2019 (COVID-19) vaccination based on the uveitis history. Retrospective matched cohort and crossover case series study. A random sample of 7 917 457 individuals who received COVID-19 vaccine between January 2021 and March 2022 in Korea, and had no recorded history of COVID-19 were categorized into the control
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Charity Care in Ophthalmology, 2024 Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-08 David J. Browning, Sally S. Ong, John G. Clarkson, Harrison Huang
To review changes in the provision of charity eye care in the past 50 years with hypothesized resulting effects on surgical training and patient outcomes. Perspective Case report, comparison of experience in community and training program settings, and selected literature review. The population to which charity care applies has shrunk as broader insurance coverage has been legislated, but in 2023 remains
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Association between Endothelial Cell Density and Corneal Thickness in Medium, Short, and Long Eyes of Han Chinese Cataract Patients Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-04 Ao Miao, Peimin Lin, Dongjin Qian, Jie Xu, Yi Lu, Tianyu Zheng
Purpose To evaluate the association between the endothelial cell density (ECD) and central corneal thickness (CCT) in medium, short, and long eyes of preoperative Han Chinese cataract patients. Design Retrospective cross-sectional study. Methods We consecutively enrolled 410 eyes, namely, 50 short eyes (axial length [AL]<22.0 mm), 150 medium eyes (22.0≤AL<24.0 mm), 120 medium-long eyes (24.0≤AL<26
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OCT Optic Nerve Head Morphology in Myopia IV: Neural Canal Scleral Flange Remodeling in Highly Myopic Eyes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-03 Anuwat Jiravarnsirikul, Hongli Yang, Jin Wook Jeoung, Seung Woo Hong, Jasmin Rezapour, Stuart Gardiner, Brad Fortune, Michaël J.A. Girard, Marcelo Nicolela, Linda Zangwill, Balwantray C. Chauhan, Claude F. Burgoyne
To compare the prevalence, location and magnitude of optic nerve head (ONH) OCT-detected, exposed neural canal (ENC), externally oblique choroidal border tissue (EOCBT) and exposed scleral flange (ESF) regions in 122 highly myopic (Hi-Myo) versus 362 non-highly myopic healthy (Non-Hi-Myo-Healthy) eyes. Cross-sectional study After OCT radial B-scan, ONH imaging, Bruch's membrane opening (BMO), the anterior
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A Prospective, Observational, Non-Interventional Clinical Study of Participants With Choroideremia: The NIGHT Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-03 Robert E. MacLaren, Byron L. Lam, M. Dominik Fischer, Frank G. Holz, Mark E. Pennesi, David G. Birch, Eeva-Marja Sankila, Isabelle Anne Meunier, Kimberly E. Stepien, Juliana Maria Ferraz Sallum, Jiang Li, Dan Yoon, Sushil Panda, James A. Gow
The NIGHT study aimed to assess the natural history of choroideremia (CHM), an X-linked inherited chorioretinal degenerative disease leading to blindness, and determine which outcomes would be the most sensitive for monitoring disease progression. A prospective, observational, multicenter cohort study. Males aged ≥18 years with genetically confirmed CHM, visible active disease within the macular region
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Cataract Surgery Outcomes in Retinitis Pigmentosa A Comparative Clinical Database Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-02 Michalis Georgiou, Ahmed F Shakarchi, Abdelrahman M Elhusseiny, Michel Michaelides, Ahmed B Sallam
To report visual acuity (VA) outcomes, intraoperative and postoperative complications of isolated cataract surgery in eyes with retinitis pigmentosa (RP), compared with non-RP-affected eyes. Retrospective clinical cohort study. A total of 113,389 eyes underwent cataract surgery between December 2010 and December 2014 at 8 clinical sites in the United Kingdom. Eyes with RP as the only comorbid pathology
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Incidence of Strabismus Post–Plaque Brachytherapy in Patients With Uveal Melanoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-01 Jordan J. Huang, Aqsa Saleem, Emily X. Liao, Matthew Larocque, Geetha Menon, Albert Murtha, Carlos Solarte, Ezekiel Weis
To determine the incidence and type of strabismus in patients with uveal melanoma treated with plaque brachytherapy. Multicenter, retrospective incidence estimation study. A total of 438 eyes of 438 patients with uveal melanoma treated with plaque brachytherapy between October 2011 and May 2021. Intervention was Iodine 125, and Palladium 103 plaque brachytherapy. The variables reviewed included incidence
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Using Natural Language Processing to Identify Different Lens Pathology in Electronic Health Records Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-01 Joshua D. Stein, Yunshu Zhou, Chris A. Andrews, Judy E. Kim, Victoria Addis, Jill Bixler, Nathan Grove, Brian McMillan, Saleha Z. Munir, Suzann Pershing, Jeffrey S. Schultz, Brian C. Stagg, Sophia Y. Wang, Fasika Woreta, SOURCE Consortium
Nearly all published ophthalmology-related Big Data studies rely exclusively on International Classification of Diseases (ICD) billing codes to identify patients with particular ocular conditions. However, inaccurate or nonspecific codes may be used. We assessed whether natural language processing (NLP), as an alternative approach, could more accurately identify lens pathology. Database study comparing
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Comment on “Prevalence and economic burden of Keratoconus in the United States” Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-01 Francisco Altamirano-Lamarque, Isdin Oke
Abstract not available
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Donor Corneal Endothelial Cell Maturity and Its Impact on Graft Survival in Glaucoma Patients Undergoing Corneal Transplantation Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-01 KOJI KITAZAWA, MUNETOYO TODA, MORIO UENO, KOICHI WAKIMASU, YASUFUMI TOMIOKA, ASAKO UEHARA, CHIE SOTOZONO, SHIGERU KINOSHITA
To examine corneal graft survival via corneal endothelial cell density (ECD) and corneal endothelial cell loss (ECL) at 5 years post transplantation in the eyes of patients with and without a history of previously undergoing glaucoma surgery according to the maturity of the donor corneal endothelial cells. Prospective cohort study. This prospective cohort study involved 17 glaucoma patients and 51
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Response to Altamirano-Lamarque et al. Comment on “Prevalence and economic burden of Keratoconus in the United States” Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-02-01 Rohan Bir Singh, Uday Pratap Singh Parmar, Vishal Jhanji
Abstract not available
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Association of Contrast Sensitivity with Eye Disease and Vision-Related Quality of Life Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-26 Kathryn Flaharty, Leslie M. Niziol, Maria A. Woodward, Angela Elam, Amanda Bicket, Olivia J. Killeen, Jason Zhang, Leroy Johnson, Martha Kershaw, Denise A. John, Sarah K. Wood, David C. Musch, Paula Anne Newman-Casey
Purpose To investigate contrast sensitivity (CS) as a screening tool to detect eye disease and assess its association with both eye disease and vision-related quality of life. Design Cross-sectional study Methods Setting & Population: Adults receiving care from a free clinic and a Federally Qualified Health Center in Michigan. Main Outcome Measures: Screening positive for eye disease and Visual Function
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Scleral thickness in simple versus complex central serous chorioretinopathy: Scleral thickness in simple versus complex CSC Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-26 Naoya Imanaga, Nobuhiro Terao, Sorako Wakugawa, Yasunori Miyara, Shota Sawaguchi, Ayano Oshiro, Yukihide Yamauchi, Hideki Koizumi
Purpose : To evaluate the association between scleral thickness and a newly developed multimodal imaging-based classification of central serous chorioretinopathy (CSC). Design Retrospective, cross-sectional study. Methods : This study included 217 eyes of 217 patients classified as simple or complex CSC based on the established protocols. Clinical and anatomical factors were compared between the two
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Detecting Fast Progressors: Comparing a Bayesian Longitudinal Model to Linear Regression for Detecting Structural Changes in Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-26 Sajad Besharati, Erica Su, Vahid Mohammadzadeh, Massood Mohammadi, Joseph Caprioli, Robert E. Weiss, Kouros Nouri-Mahdavi
Purpose Demonstrate that a novel Bayesian hierarchical spatial longitudinal (HSL) model identifies macular superpixels with rapidly deteriorating ganglion cell complex (GCC) thickness more efficiently than simple linear regression (SLR). Design Prospective cohort study. Setting Tertiary glaucoma center. Subjects 111 eyes (111 patients) with moderate to severe glaucoma at baseline and ≥4 macular optical
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Genetic characteristics and clinical manifestations of foveal hypoplasia in familial exudative vitreoretinopathy Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-26 Yuqiao Ju, Lili Zhang, Fengjuan Gao, Yuan Zong, Tianhui Chen, Lu Ruan, Qing Chang, Ting Zhang, Xin Huang
PURPOSE This study aimed to ascertain the occurrence of foveal hypoplasia (FH) in individuals diagnosed with familial exudative vitreoretinopathy (FEVR). DESIGN Retrospective cohort study. METHODS In this study, FEVR families and sporadic cases were diagnosed at the Eye & ENT Hospital, Fudan University, between 2017 and 2023. All patients attended routine ophthalmologic examinations and genetic screenings
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Reply to Comment on: Non-Infectious Outcomes of Intravitreal Antibiotic-Steroid Injection and Topical NSAID Versus Triple Drop Therapy Post Cataract Surgery Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-26 Kamran M. Riaz, Kai Ding, Asim V. Farooq
Abstract not available
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How would nature see our corneal triumphs? The LXXIX Edward Jackson Lecture Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-26 Gerrit R.J. Melles, Jack S. Parker
Purpose To describe discrepancies between clinical observation and current teachings in corneal endothelial disease, particularly in Fuchs endothelial dystrophy and its potential association with primary open angle glaucoma. Design and methods Perspective on Fuchs dystrophy, a disorder that commonly presents with a compromised endothelium but minimal stromal edema, indicating that the corneal imbibition
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Long-Term Effect of Systemic Comorbidity on Glaucoma Medication Adherence Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-24 Chiun-Ho Hou, Christy Pu
Purpose To determine whether systemic comorbidity is associated with reduced adherence to glaucoma medication and whether this decrease varies according to the number of comorbidity and the time after glaucoma onset. Design Cohort study Methods Setting: Population-based. Study population: All patients with confirmed newly diagnosed glaucoma in one or both eyes were identified using National Health
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Endogenous Fungal Endophthalmitis: A Single-Center Retrospective Study and Review of the Literature Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-26 Eleanor Burton, Vishal Reddy, Arthi G. Venkat
To evaluate factors that inform systemic antifungal choices in patients with endogenous fungal endophthalmitis (EFE). Single-institution retrospective case series. Charts of EFE patients from 2010 to 2023 were reviewed. Patients treated systemically for EFE with a minimum of 14 days of follow-up were included. Outcome measures included time to improvement in vitritis or chorioretinitis, systemic therapy
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Comment on Non-Infectious Outcomes of Intravitreal Antibiotic-Steroid Injection and Topical NSAID Versus Triple Drop Therapy Post Cataract Surgery Am. J. Ophthalmol. (IF 4.2) Pub Date : 2024-01-24 Gary D. Novack
Abstract not available