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Drusen and other retinal findings in people with IgA glomerulonephritis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-25 Ursula Greferath, Erica Fletcher, Judy Savige, Heather G Mack
Purpose Retinal drusen have been described in people with IgA nephropathy. We examined the frequency of drusen in IgA nephropathy, and compared their location and composition with those for drusen in age-related macular degeneration. Design Immunohistological case series of eyes of patients with IgA nephropathy, and a comparison eye with age-related macular degeneration. Methods Donor eyes from four
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Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-19 Golnoush Mahmoudinezhad, Sasan Moghimi, Jiacheng Cheng, Liyang Ru, Dongchen Yang, Kushagra Agrawal, Rajeev Dixit, Siavash Beheshtaein, Kelvin H. Du, Kareem Latif, Gopikasree Gunasegaran, Eleonora Micheletti, Takashi Nishida, Alireza Kamalipour, Evan Walker, Mark Christopher, Linda Zangwill, Nuno Vasconcelos, Robert N. Weinreb
Purpose To develop deep learning (DL) models estimating the central visual field (VF) from optical coherence tomography angiography (OCTA) vessel density (VD) measurements. Design Development and validation of a Deep Learning model Methods A total of 105110-2 VF OCTA pairs from healthy, glaucoma suspects, and glaucoma eyes were included. DL models were trained on enface macula VD images from OCTA to
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THE HUMIRA IN OCULAR INFLAMMATIONS TAPER (HOT) STUDY Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-19 Francesco Pichi, Scott D Smith, Debra A Goldstein, Dina Baddar, Terese K A Gerges, Timothy M Janetos, Matilde Ruiz-Cruz, Luz Elena Concha-del-Río, Kazuichi Maruyama, Josianne Carina ten Berge, Saskia M Rombach, Luca Cimino, Elena Bolletta, Elisabetta Miserocchi, Pierluigi Scandale, Massimiliano Serafino, Paola Camicione, Sofia Androudi, Julio J Gonzalez-Lopez, Lyndell L. Lim, Piergiorgio Neri
Purpose To assess factors that impact the risk of relapse in patients with non-infectious uveitis (NIU) who undergo adalimumab tapering after achieving remission. Design Retrospective study. Methods − Setting: Multicenter study. − Study Population: Patients with NIU treated with adalimumab and subsequently tapered. − Observation Procedure: Patient demographics, type of NIU, onset and duration of disease
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Non-infectious uveitis risk after Coronavirus Disease 2019 (COVID-19) vaccination: A nationwide retrospective cohort study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-20 Myung Soo Chang, Hae Rang Kim, Sunyeop Kim, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim
Purpose To investigate the incidence and risk of non-infectious uveitis (NIU) following Coronavirus Disease 2019 (COVID-19) vaccination compared to an unvaccinated, uninfected control group. Design Retrospective population-based cohort study Methods We included 5,185,153 individuals who received the first vaccine dose in the exposed group and 2,680,164 individuals in the unexposed, uninfected control
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Comorbidity of Ocular and Facial Demodicosis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-20 Wei-Lun Huang, Chang-Ming Huang, Chia-Yu Chu, Fung-Rong Hu
Purpose To determine the association between ocular and facial demodicosis, and the effect of facial treatment on ocular demodicosis. Design Prospective clinical cohort study. Methods Ocular demodicosis outpatients from a tertiary medical center were enrolled from April to December 2020. The diagnosis was based on epilation of four eyelashes from each upper eyelid. High ocular Demodex load (ODL) was
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The epidemiology and risk factors for the progression of sympathetic ophthalmia in the United States: An IRIS® Registry Analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-17 Nathan Hall, Vivian Paraskevi Douglas, Alexander Ivanov, Connor Ross, Tobias Elze, John H. Kempen, Lucia Sobrin, Joan W. Miller, Alice Lorch
Purpose To investigate the demographic and clinical characteristics of patients with sympathetic ophthalmia (SO) and define the risk factors for its incidence following trauma and ophthalmic procedures. Design Retrospective cohort study. Participants Patients in the American Academy of Ophthalmology's (Academy) IRIS® Registry (Intelligent Research in Sight) who were (n=1,523) or were not diagnosed
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Network Meta-analysis of IOL Power Calculation Formula Accuracy in 1,016 Eyes with Long Axial Length Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-17 Yiyuan Ma, Ruilin Xiong, Zhenzhen Liu, Charlotte Aimee Young, Yue Wu, Danying Zheng, Xinyu Zhang, Guangming Jin
PURPOSE To systematically review the literature and quantitatively synthesize the currently available evidence to compare the accuracy of different intraocular lens calculation formulas in eyes with long axial length (AL). DESIGN Network meta-analysis. METHODS PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched for studies published between January 2000 and June 2022
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Surgical resection of a retinal pigment epithelium adenoma with exudative retinal detachment Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-15 Yosuke Harada, Tomona Hiyama, Keita Kihara
Abstract not available
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Leber Hereditary Optic Neuropathy Gene Therapy: Longitudinal Relationships Among Visual Function and Anatomical Measures: LHON Gene Therapy: Visual Function and Anatomical Measures Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-15 Byron L. Lam, William J. Feuer, Vittorio Porciatti, Janet L. Davis, D. Diane Zheng, Elizabeth A. Vanner, Eleonore J. Savatovsky, Diego E. Alba, John Guy
Purpose To assess longitudinal relationships among visual function and anatomical measures of gene therapy in G11778A Leber hereditary optic neuropathy (LHON). Design Phase 1 clinical trial. Methods Setting: single institution. Participants: Patients with G11778A LHON and chronic bilateral visual loss >12 months (Group 1,n=11), acute bilateral visual loss <12 months (Group 2,n=9), or unilateral visual
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Topographic Correlation of Microperimetry with Structural Characteristics in Diabetic Macular Ischemia Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-14 Wei-Shan Tsai, Sridevi Thottarath, Sarega Gurudas, Elizabeth Pearce, Andrea Giani, Sobha Sivaprasad
PURPOSE This study aimed to determine the threshold for defining abnormal retinal sensitivity (RS) that correlates with structural changes in diabetic macular ischemia (DMI) patients with stable treated proliferative diabetic retinopathy (PDR). DESIGN Prospective cross-sectional study. METHODS In a single center, we recruited 85 eyes (67 patients) with stable treated PDR with best-corrected visual
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The Association Between Frailty and Visual Field Loss in U.S. Adults Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-14 Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Purpose : To describe the association between visual field loss and frailty in a nationally representative cohort of U.S. adults. Design Retrospective cross-sectional study. Methods : The cohort included adults 40 years or older with complete eye examination data from the 2005-2006 and 2007-2008 National Health and Nutrition Examination Surveys (NHANES). Visual field loss (VFL) was determined by frequency
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Comment on: Long-term Impact of Immediate Versus Delayed Treatment of Early Glaucoma: Results From the Early Manifest Glaucoma Trial Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-09 Dr. Mithun Thulasidas, Dr. Pooja Patil, Dr. Paraali Shah
Abstract not available
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Yield of Investigations in Young Patients Presenting with Transient Monocular Vision Loss: A Prospective Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-09 Irina Sverdlichenko, Laura Donaldson, Edward Margolin
Background It is unclear whether transient monocular vision loss (TMVL) warrants the same thorough systemic evaluation for potential embolic sources in young adults as it does in older adults. The objective of the present study was to evaluate the yield of investigations in patients under 45 years old presenting with TMVL. Design Prospective cohort study. Methods Young patients with TMVL presenting
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Validation of a Published Model to Reduce Burden of Retinopathy of Prematurity Screening Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-09 Jaron Pruett, Kelly Ruland, Sean Donahue
Purpose The E-ROP study evaluated 1257 patients screened for retinopathy of prematurity (ROP) and found that no infant born at or after 27 weeks’ gestational age and having birth weight over 750g developed treatable disease if they had no ROP at 37 weeks’ gestational age. They suggested there is little value in continued screening of infants meeting these criteria who have no ROP at 37 weeks. We attempted
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Evaluating the Effect of a Myopia Control Spectacle Lens Among Children in Israel: 12-Month Results Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-09 Cohen Yuval, Chassid Otzem, Benhaim-Sitbon Laura, Ratzon Shirel, Gotthilf-Nezri Dana, Weiss Atalia, Baran Noam, Erdinest Nir, Morad Yair
Purpose To investigate the effectiveness of a novel spectacle lens designed to slow the progression of myopia in children. Design A prospective, randomized, double blind clinical trial. Methods 126 Israeli children aged 6-13 with spherical equivalent (SER) refractive errors of -0.5 to -6.25 D, were randomized into either the Shamir Myopia Control (SMC) lens design group, or the conventional single-vision
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Response to Comments on: Longterm Impact of Immediate Versus Delayed Treatment of Early Glaucoma. Results from the Early Manifest Glaucoma Trial Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-09 Anders Heijl, Dorothea Peters, Boel Bengtsson
Abstract not available
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Association of Bergmeister's papilla and deep optic nerve head structures with prelaminar schisis of normal and glaucomatous eyes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-09 Hitomi Saito, Takashi Ueta, Makoto Araie, Nobuko Enomoto, Mitsuki Kambayashi, Hiroshi Murata, Tsutomu Kikawa, Kazuhisa Sugiyama, Tomomi Higashide, Atsuya Miki, Aiko Iwase, Goji Tomita, Toru Nakazawa, Makoto Aihara, Kyoko Ohno-Matsui, Tae-Woo Kim, Christopher Kai Shun Leung, Linda M Zangwill, Robert N Weinreb
Purpose To investigate factors associated with the severity of prelaminar schisis (PLS) in heathy subjects and glaucoma patients. Design Prospective cross-sectional study Methods Two hundred seventeen eyes of 217 subjects (110 normal eyes and 107 open angle glaucoma eyes). Frequency and severity of PLS were compared between normal and glaucomatous eyes. Multivariate logistic models were used to assess
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Alabama Screening and Intervention for Glaucoma and Eye Health through Telemedicine (AL-SIGHT): Baseline Results Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-07 Cynthia Owsley, Thomas A. Swain, Gerald McGwin, Van Thi Ha Nghiem, Shilpa Register, Irfan M. Asif, Massimo Fazio, Ellen K. Antwi-Adjei, Christopher A. Girkin, Lindsay A. Rhodes
Purpose To describe baseline results of the Alabama Screening and Intervention for Glaucoma and eye Health through Telemedicine (AL-SIGHT) for patients at federally qualified health centers (FQHC's). Candidates were persons at-risk for glaucoma associated diseases (GAD) based on age, race/ethnicity, current diagnosis of GAD, family history, and diabetes. Design Baseline screening visit followed by
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Minimum corneal diameter and anterior steep axis curvature share the same meridian: A novel finding Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-03 Mathew Francis, Himanshu Matalia, Ansu Ann John, Jyoti Matalia, Nandini Chinnappaiah, Prarthana Bhandary, Rohit Shetty, Rudy M.M.A. Nuijts, Abhijit Sinha Roy
Purpose To define the external scleral sulcus (ESS) on a Scheimpflug image and use it for a morphometric analysis of corneal diameter (CD). Design Retrospective, cross-sectional study of pediatric Asian-Indian eyes. Methods One random eye of 353 subjects between 5 to 18 years underwent 25-scan Pentacam HR imaging. For all scans, densitometry values along the anterior corneal edge were recorded and
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OCT Optic Nerve Head Morphology in Myopia III: The Exposed Neural Canal Region in Healthy Eyes – Implications for High Myopia Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-05 Seungwoo Hong, Hongli Yang, Stuart K. Gardiner, Haomin Luo, Glen P. Sharpe, Joseph Caprioli, Shaban Demirel, Christopher A. Girkin, Christian Y. Mardin, Harry A. Quigley, Alexander F. Scheuerle, Brad Fortune, Anuwat Jiravarnsirikul, Camila Zangalli, Balwantray C. Chauhan, Claude F. Burgoyne
Purpose To determine the prevalence and magnitude of OCT exposed neural canal (ENC), externally oblique choroidal border tissue (EOCBT), and exposed scleral flange (ESF) regions in 362 non-highly myopic (spherical equivalent -6.00 to 5.75 diopters) eyes of 362 healthy subjects. Design Cross-sectional study Methods After OCT optic nerve head (ONH) imaging, Bruch's membrane opening (BMO), the anterior
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Risk of Stroke, Myocardial Infarction, Deep Vein Thrombosis, Pulmonary Embolism, and Death after Retinal Vein Occlusion Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-01 Karen M. Wai, Cassie A. Ludwig, Euna Koo, Ravi Parikh, Prithvi Mruthyunjaya, Ehsan Rahimy
Purpose To examine rates of stroke, myocardial infarction (MI), deep vein thrombosis (DVT), pulmonary embolism (PE), and death in patients after retinal vein occlusion (RVO) compared to controls. Design Retrospective cohort study. Methods An aggregated electronic health records research network, TriNetX (Cambridge, MA, USA), was used to identify patients with diagnosis of RVO and a control group of
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Exudative Progression of Treatment-Naïve Non-Exudative Macular Neovascularization in Age-Related Macular Degeneration: A Systematic Review with Meta-Analyses Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-09-01 Anne Helene Køllund Nissen, Hans Christian Kiilgaard, Elon H.C. van Dijk, Javad Nouri Hajari, Josef Huemer, Claudio Iovino, Miklos Schneider, Torben Lykke Sørensen, Jakob Grauslund, Yousif Subhi
Purpose To systematically review and report the rate of exudative progression over time in patients with non-exudative macular neovascularization (MNV) in age-related macular degeneration (AMD). Design Systematic review with prevalence meta-analyses and individual participant meta-analysis. Methods We searched 10 literature databases on March 26, 2023, for studies of consecutive patients with treatment-naïve
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CORNEAL SENSITIVITY IS INVERSELY CORRELATED WITH SEVERITY OF DIABETIC RETINOPATHY IN A PREDOMINANTLY UNDERREPRESENTED POPULATION Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-27 Michael Singer, Preston O'Brien, Luke Mein
Purpose To assess the relationship between diabetic retinopathy (DR) and corneal sensitivity. Methods In this prospective study, 100 eyes of 50 patients from primarily underrepresented racial and ethnic backgrounds with DR underwent assessment of corneal sensitivity using a Cochet-Bonnet esthesiometer. Severity of DR was graded by a masked reading center. Corneal sensitivity was compared in eyes with
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Increased risk of optic neuritis in patients with Fibromyalgia: nationwide population-based cohort study in South Korea Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-26 Hyung Rae Cho, Geung Kyu Lee, Ju-Yeun Lee
Purpose To estimate the risk of incidence of optic neuritis and identify the high-risk group among patients with fibromyalgia (FM) Design Population-based cohort study Methods A nationwide, population-based study was conducted using data from the Korean National Health Claims database from 2012 to 2021. This study included all the patients with FM from the entire South Korean population aged 20–79
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Progressive changes in the anterior segment and their impact on the anterior chamber angle in primary angle closure disease Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-26 Jiehoon Kwak, Kilhwan Shon, Yunhan Lee, Kyung Rim Sung
Purpose To investigate longitudinal changes in the anterior segment (AS) using serial optical coherence tomography (OCT) images and determine impact of these changes on the anterior chamber angle (ACA) in eyes with primary angle closure disease (PACD) treated with laser peripheral iridotomy (LPI). Design Retrospective clinical cohort study. Methods This study included 103 patients with PACD who underwent
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Ocular Manifestations and Outcomes in Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Comparison with Adult Patients Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-25 Yueh-Ling Chen, Tsung-Ying Tsai, Li-Yen Pan, Yueh-Ju Tsai, Shin-Yi Chen, Ching-Hsi Hsiao, Lung-Kun Yeh, Hsin-Yuan Tan, Hung-Chi Chen, Kuo-Hsuan Hung, Wuyong Quan, Chun-Bing Chen, Wen-Hung Chung, David Hui-Kang Ma
Purpose To compare the clinical features and visual outcomes in children and adults with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Design Retrospective comparative case series. Methods This retrospective study included 280 eyes of 140 patients (35 children and 105 adults) with SJS/TEN treated between 2010 and 2020. The primary outcome measures were the final best corrected
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The “Time in Range” Concept in Ophthalmology Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-23 Igor Kozak, Michael W. Stewart
Abstract not available
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Tube Versus Trabeculectomy IRIS Registry Study: 1-Year Secondary Treatment Outcomes Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-23 Catherine Q. Sun, Matthew J. McSoley, Flora Lum, Ta C. Chang, Steven J. Gedde, Elizabeth A. Vanner
PURPOSE To describe 1-year secondary outcomes in the Tube Versus Trabeculectomy IRIS® (Intelligent Registry In Sight) Registry Study (TVTIRIS), and to compare to the TVT randomized controlled trial (TVTRCT). DESIGN TVTIRIS was a retrospective cohort study. METHODS The 2013-2017 IRIS Registry was used to identify eyes that received a tube shunt (tube) or trabeculectomy after a previous trabeculectomy
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Development and Validation of the Low Vision Severely Constricted Peripheral Eyesight (LV-SCOPE) Questionnaire Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-23 Joshua R. Ehrlich, Chris Andrews, Abigail Kumagai, Jenna Goldstein, K. Thiran Jayasundera, Joan Stelmack, Robert Massof, Paul P. Lee, Noelle E. Carlozzi
PURPOSE To develop and validate a novel patient-reported outcome (PRO) measure to assess vision-related functioning in individuals with severe peripheral field loss (PFL). DESIGN Prospective outcome measure development/validation study. METHODS A 127-item questionnaire was developed based on a prior qualitative interview study. A total of 116 participants with severe PFL due to retinitis pigmentosa
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Rotational stability of toric capsular bag fixated IOLs in duet procedure for reversible trifocality Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-18 Isabella D. Baur, Gerd U. Auffarth, Maximilian K. Köppe, Grzegorz Łabuz, R. Khoramnia
Purpose : To evaluate the long-term rotational stability of capsular bag-fixated toric intraocular lenses (IOLs) in polypseudophakic eyes of patients who underwent duet procedure for reversible trifocality. Design : Retrospective interventional case series. Methods : We included 34 eyes of 20 patients who underwent duet procedure with implantation of a monofocal toric IOL (RayOne toric, Hoya XY1AT
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Clinical Outcome of Amniotic Membrane Transplant in Ocular Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis at a Major Burn Unit Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-19 Xavier M. Mortensen, Nathan T. Shenkute, Alice Yang Zhang, Hussam Banna
PURPOSE To analyze the clinical outcome of amniotic membrane transplantation in patients with ocular Stevens–Johnson syndrome/toxic epidermal necrolysis at a major burn unit. DESIGN Retrospective, non-randomized interventional study. METHODS A retrospective chart review from April 2014 to January 2022 of 43 patients (85 eyes) at a burn center who underwent amniotic membrane transplantation (AMT) for
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Factors associated with Incidental Retinal Emboli in the US Adult Population Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-13 Sean Teebagy, Benjamin G. Jastrzembski, Isdin Oke
Purpose To estimate the prevalence of incidental retinal emboli and identify associated factors using a nationally representative sample of the US population. Design Cross-sectional study. Methods Setting: 2005-2008 National Health and Nutrition Examination Survey (NHANES) Study population: All adults aged ≥ 40 years Observation: Incidental retinal emboli were identified through retinal fundus photography
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Relationship of Choroidal Microvasculature Dropout and Beta-Zone Parapapillary Area with Visual Field Changes in Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-12 Kareem Latif, Takashi Nishida, Sasan Moghimi, Eleonora Micheletti, Kelvin Du, Robert N. Weinreb
Purpose To evaluate the association between rates of choroidal microvasculature dropout (MvD) change, beta-zone parapapillary atrophy (β-PPA) area change, and visual field (VF) changes in primary open-angle glaucoma (POAG) eyes. Design Retrospective, observational cohort study Methods In a tertiary glaucoma clinic, we included 76 eyes from 58 POAG patients with and without localized MvD, who had at
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Influence of Goniotomy Size on Treatment Safety and Efficacy for Primary Open-Angle Glaucoma: A Multicenter Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-11 Yu Zhang, Ping Yu, Yingzhe Zhang, Kazunobu Sugihara, Xiaomin Zhu, Yao Zhang, Xiao Yang, Xiaoyan Li, Yacong Liu, Hengli Zhang, Xiaowei Yan, Hengkai Zhang, Fengbin Lin, Yunhe Song, Xinbo Gao, Huiping Yuan, Guangxian Tang, Wenzong Zhou, Sujie Fan, Guangfu Dang, Xiulan Zhang
Purpose To compare the efficacy and safety of 120°, 240°, and 360° goniotomy (GT) with or without phacoemulsification with intraocular lens implantation (PEI) for primary open-angle glaucoma (POAG). Design Multicenter, retrospective, comparative, non-randomized interventional study. Methods Patients diagnosed with POAG who underwent GT with or without PEI were included, and divided into six groups:
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Parental Corneal Tomographic and Biomechanical Characteristics of Patients with Keratoconus Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-10 Jie Li, Bi Ning Zhang, Vishal Jhanji, Xiaochuan Wang, Dewei Li, Xianli Du
Purpose To investigate the hereditability of corneal tomographic and biomechanical parameters in keratoconus (KC). Design Prospective cohort study. Methods Setting: Qingdao Eye Hospital of Shandong First Medical University, Shandong, China. Study Population A total of 44 patients with KC and their biological parents (n = 88) were recruited as the study group. The control group consisted of 84 healthy
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A novel heterozygous TGFBI c.1613C > A pathogenic variant is associated with lattice corneal dystrophy in a Chinese family Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-09 Mengjun Fu, Shan Duan, Xiaobo Zhang, Jiahao Wang, Sheng Wang, Zai-Long Chi
Purpose To investigate the gene mutations and relationship of clinical manifestation in a Chinese family with familial lattice corneal dystrophy (LCD). Design Single-family case-control study. Methods A family with familial LCD was recruited for this study. A total of 10 affected and 13 healthy family members participated in this research. Clinical features were examined by slit-lamp examination and
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Salary Negotiations: Gender Differences in Attitudes, Priorities and Behaviors of Ophthalmologists Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-09 Shefali Sood, Alcina K Lidder, Ceyhun Elgin, Janice C Law, Aakriti Garg Shukla, Bryan J Winn, Albert S Khouri, Eydie G Miller-Ellis, John Laudi, Jeffrey R SooHoo, Eva DeVience, Misha F Syed, Allen Zerkin, Lama A Al-Aswad
Purpose : To investigate attitudes, priorities, and behaviors of ophthalmologists in salary negotiations. Design : Cross-sectional study. Methods : A Qualtrics survey was disseminated to United States based practicing ophthalmologists between 11/1/2021 and 3/31/2022 and assessed attitudes, behaviors and priorities surrounding salary negotiation during the respondents’ first negotiation as a practicing
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Risk Factors for Flat Anterior Chamber Requiring Intervention After Glaucoma Drainage Implant: A Retrospective Case-Controlled Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-09 Huda Sheheitli, Ann V. Quan, Elizabeth A. Vanner, Richard K. Parrish
PURPOSE To identify risk factors for flat anterior chamber that required additional intervention in the postoperative period (90 days) after uncomplicated Baerveldt Glaucoma Implant (BGI) surgery. DESIGN Retrospective, matched case-control study. METHODS A total of 42 cases (eyes) that received BGI at Anne Bates Leach Eye Hospital between February 1, 2011, and January 1, 2019, and that developed flat
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Reply to the comment on: Recommendation for presbyopia-correcting intraocular lenses: A Delphi consensus statement by the ESASO study group Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-06 Vito Romano, David Madrid-Costa, Jose F. Alfonso, Jorge Alio, Bruce Allan, Romesh Angunawela, Gerd Auffarth, Francesco Carones, Ramin Khoramnia, Johnny Moore, Mayank A. Nanavaty, Giacomo Savini, Luca Pagano, Mario R Romano, Gianni Virgili, Luis Fernández-Vega-Cueto
Abstract not available
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Comparison of femtosecond laser assistance and manual trephination in deep anterior lamellar keratoplasty in the treatment of keratoconus: a meta-analysis Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-06 Kaiyue Du, Enshuo Liu, Nan Li, Bowei Yuan, Rongmei Peng, Jing Hong
Purpose To compare the efficacy and safety of femtosecond laser–assisted deep anterior lamellar keratoplasty (F-DALK) with those of manual-trephination deep anterior lamellar keratoplasty (M-DALK) in treating keratoconus. Design Systematic review and meta-analysis. Methods Through November 2022, we comprehensively searched PubMed, EMBASE, the Cochrane Library, and four Chinese databases. Studies that
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Role of Static and Dynamic Ocular Biometrics Measured in the Dark and Light as Risk Factors for Angle Closure Progression Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-06 Austin Cho, Benjamin Y. Xu, David S. Friedman, Paul J. Foster, Yu Jiang, Anmol A. Pardeshi, Yuzhen Jiang, Tin Aung, Mingguang He
PURPOSE To assess the role of static and dynamic ocular biometric parameters measured in the dark and light for predicting progression of primary angle closure suspect (PACS) to primary angle closure (PAC). DESIGN Retrospective cohort study using prospective randomized controlled trial data from untreated, control eyes. METHODS Zhongshan Angle Closure Prevention Trial subjects underwent anterior segment
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Ocular Surface Evaluation in Immunoglobulin G4–Related Ophthalmic Disease Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-05 Kenneth K.H. Lai, Xulin Liao, Fatema Mohamed Ali Abdulla Aljufairi, Yiu Man Wong, Jamie T. Chiu, H.T. Mak, Andy C.O. Cheng, Joyce K.Y. Chin, Benjamin C.Y. Chu, Chi Ho Kwong, Kenneth K.W. Li, W.H. Chan, Wilson W.K. Yip, Alvin L. Young, Edwin Chan, Callie K.L. Ko, Simon T.C. Ko, Carmen K.M. Chan, Hunter K.L. Yuen, Li Jia Chen, Kelvin K.L. Chong
PURPOSE To evaluate the functional and structural changes of the meibomian glands and ocular surface in immunoglobulin G4–related ophthalmic disease (IgG4-ROD) patients. DESIGN Cross-sectional, matched case-control comparison study. METHODS This study included 64 patients with biopsy-proven IgG4-ROD (aged 63.4 ± 12.2 years, 39 male) and 64 sex- and age-matched healthy controls. Patients were managed
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OCT Grading System of Macular Infarction Predicts Vision in Participants With Central Retinal or Hemiretinal Vein Occlusion: A Secondary Analysis of SCORE2 Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-05 Adrian Au, Michael Ip, Barbara A. Blodi, Ingrid U. Scott, Neal L. Oden, Paul C. Van Veldhuisen, David Sarraf
PURPOSE To determine whether macular infarction measured as hyper-reflectivity of the middle and inner retinal layers predicts long-term visual acuity outcomes in participants with central retinal vein occlusion (CRVO) or hemi-retinal vein occlusion (HRVO). DESIGN Clinical cohort study using post hoc secondary analysis of phase 3 clinical trial data. METHODS This post hoc secondary analysis of the
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Preoperative risk factors for proptosis recurrence after rehabilitative orbital decompression in Graves’ orbitopathy patients Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-04 Hyeong Ju Byeon, JaeSang Ko, Don O. Kikkawa, Jin Sook Yoon
Purpose Rehabilitative orbital decompression treats disfiguring exophthalmos in Graves’ orbitopathy (GO) patients. This study aimed to identify risk factors associated with the postoperative recurrence of proptosis after orbital decompression. Design Retrospective case-control study Methods This retrospective review included patients with GO who underwent rehabilitative orbital decompression for disfiguring
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Comment on: Recommendation for presbyopia-correcting intraocular lenses: A Delphi consensus statement by the ESASO study group Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-03 Raimo Tuuminen, Sohee Jeon, Piotr Kanclerz
Abstract not available
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Outcomes of filtering surgery versus clear lens extraction in young patients with angle-closure glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-03 Mengwei Li, Wenqing Zhu, Xintong Fan, Xinghuai Sun, Xiangmei Kong
Purpose To compare the effect of filtering surgery versus clear lens extraction in young patients with medically uncontrolled angle-closure glaucoma (ACG). Design Retrospective, non-randomized, comparative, interventional study. Methods We reviewed the medical charts of patients with the following scenarios: (1) age ≤ 40 years, (2) diagnosis of ACG without cataract, including primary angle-closure
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Comment on Performance of Generative Large Language Models on Ophthalmology Board Style Questions Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-02 Amnuay Kleebayoon, Viroj Wiwanitkit
Abstract not available
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Reply to Comment on Performance of a Generative Large Language Models on Ophthalmology Board Style Questions Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-08-02 Louis Z. Cai, Chrisfouad Alabiad
Abstract not available
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Non-Surgical Consecutive Exotropia following Childhood Esotropia: A Multicentered Study Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-29 Linda Colpa, Sina Khalili, Stephen Kraft, Darron Bacal, Coralie Hemptinne, Demet Yuksel, Alfred Cossari, Kamiar Mireskandari
Purpose Non-surgical consecutive exotropia (NCX) occurs when an esotropia (ET) spontaneously converts to exotropia (XT) without surgical intervention. Although considered to occur in early onset accommodative esotropia with high hyperopia, consensus on causation is lacking. We report the clinical characteristics of NCX and assess response to conservative management. Design Retrospective, multi-centered
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Outcomes of Intentionally Suspending Treatment in Eyes With Advanced Neovascular Age-Related Macular Degeneration Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-28 Katherine C. Awh, Raziyeh Mahmoudzadeh, Mirataollah Salabati, Hana A. Mansour, Joseph Bechay, John Magagna, Carl D. Regillo, Allen C. Ho, Sunir J. Garg, Jason Hsu
PURPOSE To determine the outcomes of intentionally suspending anti–vascular endothelial growth factor (anti-VEGF) injections in eyes with advanced neovascular age-related macular degeneration (nAMD). DESIGN Retrospective cohort study. METHODS The study sample comprised 93 patients with nAMD and best available Snellen visual acuity (VA) ≤20/400 in which anti-VEGF treatment was suspended by the treating
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Microcatheter-Assisted Circumferential Trabeculotomy After Failed Glaucoma Surgeries in Childhood Glaucoma Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-27 Lei Fang, Yingting Zhu, Shufen Lin, Yihua Su, Liming Chen, Pingping Liu, Yimin Zhong, Xing Liu
PURPOSE To evaluate the outcomes of microcatheter-assisted trabeculotomy (MAT) in childhood glaucoma (primary congenital glaucoma [PCG], juvenile open-angle glaucoma [JOAG], and secondary childhood glaucoma [SCG]) after failed glaucoma surgery. DESIGN Retrospective interventional case series. METHODS Patients with childhood glaucoma who underwent MAT after failed glaucoma surgery with at least 12 months
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An Eye on the Brain: Adding Insight to Injury Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-25 Helen Victoria Danesh-Meyer
Abstract not available
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Vitreoretinal involvement of caterpillar hairs Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-24 Jing-yan Yang, Xiang-yu Shi
Abstract not available
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Assessing Change in Exudative Age-Related Macular Degeneration With Macular Thickness Maps as a Surrogate Strategy for Remote Patient Monitoring Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-25 Omer Trivizki, Masha Varcheie, Simon Bello, Ian Raden, Prashanth Iyer, Marlyn Marquez, Amina Chaudhry, Alaa Al-Dabbagh, Giovanni Gregori, Philip J. Rosenfeld
PURPOSE To determine if macular thickness maps (MTMs) are sufficient to guide management of eyes with exudative age-related macular degeneration (eAMD), we compared the ability to detect change using MTMs with the ability to detect change using the entire optical coherence tomography (OCT) scan in patients undergoing therapy. DESIGN Retrospective, comparative diagnostic analysis. METHODS Patients with
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Depression in Individuals With Diabetic Retinopathy in the US National Health and Nutrition Examination Survey, 2005-2008 Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-24 Girish Valluru, Allen Costa, Janek Klawe, Bian Liu, Avnish Deobhakta, Sumayya Ahmad
PURPOSE To examine the relationship between diabetic retinopathy (DR) and depression in the United States. DESIGN Retrospective, cross-sectional study. METHODS National Health and Nutrition Examination Survey (NHANES) participants between 2005 and 2008 (ages 40-85 years) were included. Prevalence of major depression among DR stages as determined by retinal imaging was estimated. Multivariable models
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Eosinophilic Angiocentric Fibrosis of the Orbit: A Clinicopathologic Review of 6 Novel Cases With Review of the Literature Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-24 Lisa Y. Lin, John H. Stone, Victor D. Liou, Anna M. Stagner, N. Grace Lee
PURPOSE To describe 6 cases and review the current state of knowledge of eosinophilic angiocentric fibrosis (EAF) involving the orbit. DESIGN Retrospective clinicopathologic case series and review of the current literature Methods Clinical records and histopathologic data of orbit-involving EAF were gathered between 2004 and 2022 from a single academic institution. The patients’ presenting clinical
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Deep Learning for Localized Detection of Optic Disc Hemorrhages Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-23 Aaron Brown, Henry Cousin, Clara Cousins, Karina Esquenazi, Tobias Elze, Alon Harris, Artur Filipowicz, Laura Barna, Kim Yonwook, Kateki Vinod, Nisha Chadha, Russ B. Altman, Michael Coote, Louis R. Pasquale
PURPOSE To develop an automated deep learning system for detecting the presence and location of disc hemorrhages in optic disc photographs. DESIGN Development and testing of a deep learning algorithm. METHODS Optic disc photos (597 images with at least 1 disc hemorrhage and 1075 images without any disc hemorrhage from 1562 eyes) from 5 institutions were classified by expert graders based on the presence
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Antibiotics versus placebo for acute bacterial conjunctivitis: findings from a Cochrane Systematic Review Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-21 Su-Hsun Liu, Yu-Yen Chen, Ulugbek Nurmatov, Onno CP van Schayck, Irene C Kuo
Purpose To summarize key findings from a Cochrane Review of the benefits and safety of antibiotic therapy compared with placebo (or vehicle) for acute bacterial conjunctivitis. Design Systematic review and meta-analysis. Methods We included placebo-controlled randomized controlled trials (RCTs) that compared topical antibiotics with placebo. We followed Cochrane methods for trial selection, data extraction
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Impact of Gender and Underrepresented in Medicine Status on Research Productivity among Ophthalmology Residency Applicants Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-20
PURPOSE Insufficient representation of women and underrepresented in medicine (URiM) students remains a problem among the ophthalmology workforce. In the residency selection process, research productivity is an important factor. We aimed to determine the average research output listed by applicants and assess for differences by gender and race. DESIGN Retrospective cohort study METHODS All San Francisco
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Corneal Collagen Cross-Linking for Progressive Keratoconus in Pediatric Patients: Up to 14 Years of Follow-up Am. J. Ophthalmol. (IF 4.2) Pub Date : 2023-07-20 Riccardo Vinciguerra, Niccolò Bordignon, Vanessa Ferraro, Cosimo Mazzotta, Pietro Rosetta, Paolo Vinciguerra
PURPOSE To assess the long-term outcomes of corneal collagen cross-linking according to the Dresden protocol (S-CXL) in progressive pediatric keratoconus (KC). DESIGN Retrospective, single-center noncomparative interventional study. METHODS Patients aged <18 years who underwent S-CXL from June 2007 to January 2011 in Humanitas Clinical and Research Center, Rozzano, Milan, Italy, and completed at least