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Avascular islands in retinopathy of prematurity with regression after intravitreal anti-VEGF injection. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-07 Ethan K Sobol,Joshua M Barnett
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Fluids aspiration for refractory PED in polypoidal choroidal vasculopathy. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-07 Ruyi Han,Min Wang,Gezhi Xu
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Effectiveness, Stability, and Influence Factors of Femtosecond Laser-assisted Arcuate Keratotomy in Cataract Surgery: A systematic Review and Meta-analysis. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-07 Baoxian Zhuo,Wenqian Shen,Lei Cai,Shuang Ni,Jiying Shen,Jin Yang
OBJECTIVES This study aimed to evaluate the effectiveness, stability, and influencing factors of femtosecond laser-assisted arcuate keratotomy (FSAK) performed during cataract surgery for correcting corneal astigmatism (CA). METHOD A systematic literature review was conducted to identify clinical trials adopting a pre-post study design. Data sources included electronic databases such as PubMed, Scopus
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Primary Merkel cell carcinoma of the eyelid. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-07 Jing Li,Tingting Ren,Jianmin Ma
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Global Burden of Eye Injuries in Children and Adolescents, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-07 Gongpeng Sun,Hong Luo,Qibo Ran,Ye Wei,Yi Zhang,Xi Huang,Meixia Zhang
PURPOSE Eye injuries are a leading cause of monocular vision impairment and disability in children and adolescents. Unlike adults, eye injuries in children exhibit significant age specificity, with worse visual outcomes due to immature vision, the risk of long-term damage, and amblyopia. However, research on the global distribution and trends of eye injury burdens in this population is limited. DESIGN
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Efficacy and Safety of Polypropylene Scleral Suture Fixation of Intraocular Lens in Pediatric Nontraumatic Ectopia Lentis: A Real-World Study. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-06 Siyuan Liu,Xinyu Zhang,Zhenzhen Liu,Charlotte Young,Zhangkai Lian,Danying Zheng,Guangming Jin
PURPOSE To report the efficacy and safety of scleral-suture fixation of intraocular lens (SFIOL) in children with nontraumatic ectopia lentis (EL) in a real-world setting. DESIGN Retrospective case series. METHODS The retrospective study included 220 eyes of 123 children with nontraumatic EL completing a minimum of 3 years postoperative follow-up, and was conducted at the Zhongshan Ophthalmic Center
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Reply to Comment on: " Epithelial Mapping Efficacy for Subclinical Keratoconus Identification ". Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-06 Barbara A L Dutra,Bassel Hammoud,Bianca N Susanna,Giuliano Scarcelli,William J Dupps,J Bradley Randleman
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Differential Impact of Central and Global Visual Field Progression on Quality of Life in Glaucoma. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-05 Gopikasree Gunasegaran,Sasan Moghimi,Evan Walker,Takashi Nishida,Jeffrey M Liebmann,Massimo A Fazio,Christopher A Girkin,Linda M Zangwill,Robert N Weinreb
PURPOSE To determine the impact of progression of central visual field (VF) and global VF on vision-related quality of life (VRQOL). DESIGN Retrospective cohort study. METHODS This study included 364 eyes of 235 primary open-angle glaucoma (POAG) participants who had at least five 24-2 VF tests over a minimum of 2-year follow-up. The slopes of global mean deviation (MD) and central mean total deviation
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Natural History of Microperimetry and Optical Coherence Tomography in USH2A-Retinopathy: A Structure-Function Association Study. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-03 Ajoy Vincent,Wendi Liang,Maureen G Maguire,Jacque L Duncan,Allison R Ayala,Paul S Bernstein,Joseph Carroll,Janet K Cheetham,Todd A Durham,Sina Farsiu,Carel B Hoyng,Rachel M Huckfeldt,Glenn J Jaffe,Jessica Loo,Mark E Pennesi,José-Alain Sahel,Mandeep S Singh,Zane Z Zemborain,David G Birch,Eleonora M Lad,
PURPOSE To describe the natural history of optical coherence tomography (OCT) and mesopic microperimetry (MP) parameters in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN Multi-center, international, prospective, longitudinal natural history study. METHODS STUDY POPULATION: 105 participants with biallelic disease-causing variants in USH2A with a clinical diagnosis
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Is There a Safe Glycemic Threshold for Cataract Surgery? Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-03 Zain S Hussain,Ahmed F Shakarchi,Muhammad Z Chauhan,Dane A Jester,Mohamed K Soliman,Ahmed B Sallam
OBJECTIVE To assess the relationship between cataract surgery and the 30-day incidence of post-operative endophthalmitis (POE) (analysis 1) and serious systemic adverse events (analysis 2) in diabetic patients with varying preoperative hemoglobin A1c (HbA1c) levels. DESIGN Retrospective, longitudinal cohort study; multicenter study using a global federated database of electronic health records. SUBJECTS
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Quantitative evaluation of trabecular meshwork in normal tension glaucoma using trabecular meshwork analyzing software. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-03 Teruhiko Hamanaka,Tetsuro Sakurai,Takuji Kato,Nobuo Ishida,Toshinari Funaki
PURPOSE This study aimed to investigate histological changes of trabecular meshwork (TM) in normal tension glaucoma (NTG) and determine whether trabeculectomy (TRAB) specimens from NTG patients can serve as normal controls for analyzing other types of high-tension glaucoma using TM analysis software (TMAS) based on light microscopy (LM). DESIGN Prospective comparative case series METHODS: TRAB specimens
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Erratum to "An Analysis of Solicitations From Predatory Journals in Ophthalmology," Am J Ophthalmol 2024; 264:216-223. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-01 Grant A Justin,Charles Huang,Michael K Nguyen,Jessica Lee,Ian Seddon,Treven A Wesley,Sophie J Bakri,J Peter Campbell,Kara Cavuoto,Megan Collins,Steven J Gedde,Andrea L Kossler,Tatyana Milman,Aakriti Shukla,Jayanth Sridhar,Zeba A Syed,Basil K Williams,Fasika A Woreta,Samir N Patel,Yoshihiro Yonekawa
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Erratum to "Disparities Between Clinical Trial Recruitment and Real-World Demographics in Macular Edema Secondary to Retinal Vein Occlusion," Am J Ophthalmol 2025; 269:429-434. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-05-01 Theodore Bowe,Collin J Richards,Hana A Mansour,Ferhina S Ali,Jayanth Sridhar,Basil K Williams,Yoshihiro Yonekawa,Michael N Cohen,David Xu,Jordan D Deaner,Meera Sivalingam,Anton Orlin,Shriji Patel,Ajay E Kuriyan
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Reply to Comment on "Dropped Lens Fragments Retrieval Using Endoscopy-Assisted Pars Plana Vitrectomy in Patients With Corneal Opacity". Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-28 Radwan S Ajlan,Martin A Mainster,Amanda K Hertel,Mary Champion
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Clinical characteristics of patients with less common causes of Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-26 Vishanna Balbirsingh,Malena Daich Varela,Michel Michaelides
PURPOSE To analyse the clinical characteristics, natural history and genetics of Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy (LCA / EOSRD) associated with uncommon genes. DESIGN Single tertiary referral centre retrospective case series. METHODS Review of clinical notes, ophthalmic images, and genetic testing results of 19 patients with disease-causing variants in genes which represent
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Reply to Comment on "COVID-19 Vaccination and Ocular Adverse Events: A Self-Controlled Case Series Study From the Entire South Korean Population". Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-26 Sungsoon Hwang,Se Woong Kang
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Ocular Adverse Events Associated with Pegcetacoplan and Avacincaptad Pegol for Geographic Atrophy: A Population-Based Pharmacovigilance Study: Ocular Adverse Events of Pegcetacoplan & Avacincaptad Pegol. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-25 Zeena Kailani,Andrew Mihalache,Marko M Popovic,Peter J Kertes,Rajeev H Muni
OBJECTIVE To evaluate the post-marketing ocular adverse events (AEs) associated with avacincaptad pegol and pegcetacoplan, the only Food and Drug Administration (FDA)-approved treatments for geographic atrophy (GA). DESIGN Retrospective cohort study (pharmacovigilance analysis). SUBJECTS AE reports in the FDA Adverse Event Reporting System (FAERS) in which pegcetacoplan or avacincaptad pegol were identified
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Evidence and Consensus-Based Imaging Guidelines in Multifocal Choroiditis with Panuveitis and Punctate Inner Choroiditis - Multimodal Imaging in Uveitis (MUV) Taskforce Report 5. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-25 Sapna Gangaputra,Aniruddha Agarwal,Jeannette Ossewaarde-van Norel,Edmund Tsui,Jennifer E Thorne,Alejandra de-la-Torre,Michael Altaweel,Jyotirmay Biswas,Srinivas Sadda,Alessandro Invernizzi,Rupesh Agrawal,Jessica G Shantha,Massimo Accorinti,Amani Fawzi,Douglas A Jabs,David Sarraf,Vishali Gupta,
PURPOSE To develop imaging and consensus-based guidelines on the application of multimodal imaging in noninfectious multifocal choroiditis and panuveitis (MFCPU) and punctate inner choroiditis (PIC). DESIGN Consensus agreement guided by the review of literature and an expert committee using nominal group technique (NGT). METHODS An expert committee applied a timed structured nominal group technique
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Influence of Age and Underlying Etiologies on Outcomes of Strabismus Surgery in the Elderly Population. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-25 Hilda Capó,Charlotte Tibi,Mariam S Vila-Delgado,Laura Huertas
PURPOSE To investigate the success of strabismus surgery in older adults and determine the impact of age and underlying etiology on surgical outcomes. METHODS Retrospective review of medical records of patients aged 60 years or older who underwent strabismus surgery at a tertiary eye care center. Surgical motor and sensory outcomes were analyzed. RESULTS Of the 562 that met criteria, patients were
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Two novel extended depth-of-focus intraocular lenses targeted for mini-monovision: a prospective randomized controlled trial. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-24 Joukje C Wanten,Noël J C Bauer,Tos T J M Berendschot,Frank J H M van den Biggelaar,Rudy M M A Nuijts
PURPOSE To compare the visual outcomes of two extended depth-of-focus (EDOF) intraocular lenses (IOLs). DESIGN Single-center prospective randomized controlled trial. METHODS Patients undergoing bilateral cataract surgery were randomly assigned to receive either the Acunex Vario IOL (Teleon Surgical B.V., Spankeren, The Netherlands) or the AcrySof IQ Vivity IOL (Alcon, Geneva, Switzerland); both Vario-
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Suprachoroidal drug delivery for VEGF suppression in wet AMD and other diseases with choroidal neovascularization. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-23 Bryce Chiang,Yooree Grace Chung,Mark R Prausnitz
PURPOSE Choroidal neovascularization caused by age-related macular degeneration, among other diseases, causes significant visual impairment. Intravitreal therapeutics inhibiting vascular endothelial growth factor (VEGF) signaling have shown excellent safety and efficacy in regressing choroidal neovascularization and improving vision. Current FDA-approved treatments deliver these drugs into the vitreous
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Pegcetacoplan Treatment for Geographic Atrophy in Age-Related Macular Degeneration Over 36 Months: Data From OAKS, DERBY, and GALE. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-23 Charles C Wykoff,Frank G Holz,Allen Chiang,David Boyer,Dilsher S Dhoot,Anat Loewenstein,Jordi Mones,Jeffrey Heier,Ashkan M Abbey,Lawrence J Singerman,Lejla Vajzovic,Jason Lin,Chao Li,Abhi Vilupuru,Caroline R Baumal,
PURPOSE To report 12-month results from the GALE open-label extension study (NCT04770545), evaluating up to 36 months of intravitreal pegcetacoplan treatment for geographic atrophy (GA) in age-related macular degeneration (AMD). DESIGN GALE is a prospective open-label extension study following the 24-month, sham-controlled, phase 3 OAKS (NCT03525613) and DERBY (NCT03525600) studies of pegcetacoplan
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Outcomes of Penetrating Keratoplasty vs Lamellar Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome: A Systematic Review and Meta-Analysis. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-19 Gábor Tóth,Szilárd Váncsa,Tamás Kói,Kitti Kormányos,Péter Hegyi,Nóra Szentmáry
PURPOSE To compare surgical outcomes following penetrating keratoplasty (PK), Descemet stripping endothelial keratoplasty (DSEK), and Descemet membrane endothelial keratoplasty (DMEK) in patients with iridocorneal endothelial (ICE) syndrome. DESIGN Systematic review and meta-analysis on individual patient data (IPD). METHODS Pre-registration was performed in the PROSPERO database (registration number:
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BIRTH OF A CHANGE AGENT: THE FOUNDING OF 'WOMEN IN OPHTHALMOLOGY'. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-19 Marjorie A Mosier,Penny Asbell,Jaqueline Lustgarten,Jane D Kivlin,Eve Higginbotham,Bronwyn Bateman
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Corneal Sensory Changes and Nerve Plexus Abnormalities in Chronic Neuropathic Ocular Pain and Dry Eye Post-Refractive Surgery. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-17 Amanda Vázquez,Marta Blanco-Vázquez,Elena Martínez-Plaza,Eva M Sobas,María J González-García,Alberto López-Miguel,Enrique Ortega,Amalia Enríquez-de-Salamanca,Margarita Calonge
PURPOSE Chronic neuropathic ocular pain (NOP) can develop alongside chronic dry eye (DE) post-laser-assisted in-situ keratomileusis (LASIK), yet its specific characteristics remain poorly understood. This study aims to compare the clinical characteristics of patients who developed both DE and NOP after LASIK to those with only DE and to asymptomatic LASIK patients, to facilitate the diagnosis of NOP
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Rate of progression among different age groups in glaucoma with high myopia: A 10-year follow-up cohort study. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-17 Jaekyoung Lee,Young In Shin,Min Gu Huh,Yoon Jeong,Young Kook Kim,Jin Wook Jeoung,Ki Ho Park
PURPOSE To investigate the rate of structural and functional progression in different age groups of highly myopic glaucoma patients and identify risk factors associated with rate of change in functional parameters. DESIGN Retrospective clinical cohort study METHODS: This study included open-angle, normal-tension glaucoma (NTG) patients with high myopia who had been followed-up for at least 8 years
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Validation of the SCREENROP Criteria for Retinopathy of Prematurity Screening: A Canadian Model for Consideration. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-16 Felicia Tai,Yasmin Jindani,Amit Mukerji,Kourosh Sabri
OBJECTIVE Reducing unnecessary retinopathy of prematurity (ROP) screenings in neonates is important for minimizing morbidity associated with such examinations including pain for the child, anxiety in parents, and conserving healthcare resources. The Seminal Canadian Recommendations for Evidence-Based Examination of Neonates for Retinopathy of Prematurity (SCREEN-ROP) guidelines recommend only screening
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Congenital restrictive strabismus associated with anomalous orbital structures: MRI findings and clinical characteristics. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-16 Dan Wang,Yan-Yan Yang,Qing-Lin Chang,Qian Ma,Yi-Di Wang,Feng-Yuan Man,Yong-Hong Jiao
PURPOSE To evaluate and classify the magnetic resonance imaging (MRI) features of anomalous orbital structures (AOS) and correlate these findings with clinical manifestations. DESIGN Retrospective, observational case series. METHODS The detailed clinical data from 35 patients diagnosed with congenital restrictive strabismus and AOS were retrospectively reviewed between July 2010 and October 2024. All
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Ethnoracial Representation in U.S. Clinical Trials for Retinal Vein Occlusion. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-15 Selina J Chang,Kabir S Grewal,Amrish Selvam,Jay Chhablani
PURPOSE Retinal vein occlusion (RVO) is the second most common cause of vision loss from retinal vascular disease. Clinical trials often lack adequate representation of minority groups, limiting the external validity and equity of trial results. We aimed to characterize the evolution of ethnoracial demographic reporting, changes in the racial & ethnic composition of RVO trial participants, and correlations
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The effects of Vitamin D on Keratoconus progression. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-15 Nicolò Bartolomeo,Matteo Pederzolli,Silvia Palombella,Philippe Fonteyne,Giuseppe Suanno,Gianluca Tilaro,Stefano de Pretis,Francesca Borgo,Federico Bertuzzi,Carlotta Senni,Massimo De Micheli,Francesco Bandello,Giulio Ferrari
PURPOSE The aim of this study was to assess whether Vitamin D (Vit D) supplementation affects local disease progression, as well as systemic inflammation, collagen degradation, and oxidative stress in adolescents affected by Keratoconus (KC) and Vit D deficiency. DESIGN Prospective, interventional single-center study. SUBJECTS Forty patients (age range, 12.2-19.9) presenting with both KC and Vit D
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Choroidal Layer Analysis Under Flat Irregular Pigment Epithelial Detachments in Central Serous Chorioretinopathy. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-14 Pasquale Viggiano,Federico Moscara,Alba Chiara Termite,Giacomo Boscia,Mariapia La Terza,Antonio Salvelli,Maria Grazia Pignataro,Annamaria Porreca,Giovanni Alessio,Francine Behar-Cohen,Francesco Boscia
PURPOSE To compare choroidal layer thickness beneath flat irregular pigment epithelial detachments (PEDs) between uncomplicated chronic central serous chorioretinopathy (uCSC) and CSC complicated by type 1 macular neovascularization (cCSC). DESIGN Retrospective cross-sectional study METHODS: This retrospective study included 94 treatment-naïve eyes (45 uCSC, 49 cCSC) with flat irregular PEDs. Using
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Understanding Patient Experience with Past Barriers to Eye Care and How Barriers were Addressed in the Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine Program. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-11 Emily Webber,Ming-Chen Lu,Maria A Woodward,Angela Elam,Amanda Bicket,Sarah Dougherty Wood,Denise John,Leroy Johnson,Martha Kershaw,Michele Heisler,Paula Anne Newman-Casey
PURPOSE To use community engaged research to understand barriers to eye care utilization and explore participant experiences with free glaucoma screenings through the Michigan Screening and Intervention for Glaucoma and eye Health through Telemedicine (MI-SIGHT) program. DESIGN Qualitative study Subjects, Participants, and/or Controls: Purposive sampling of 42 participants out of 254 total participants
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Unilateral Conjunctival Parakeratosis: A Rare Case of Mucosal Keratosis with Pathological Findings Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-11 Hitoshi Hayashi, Shizuka Koh
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Deep Learning Approach Readily Differentiates Papilledema, Non-Arteritic Anterior Ischemic Optic Neuropathy, and Healthy Eyes Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-11 David Szanto, Asala Erekat, Brian Woods, Jui-Kai Wang, Mona Garvin, Brett A. Johnson, Randy Kardon, Edward Linton, Mark J. Kupersmith
Deep learning (DL) has been used in differentiating a range of ophthalmic conditions. We describe a model to distinguish among fundus photos of acquired optic disc swelling due to idiopathic intracranial hypertension (IIH), non-arteritic anterior ischemic optic neuropathy (NAION), and healthy eyes.
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Racial and Ethnic Differences in the Association Between Statin Use and the Risk of Ocular Hypertension and Open-Angle Glaucoma Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-07 Abdelrahman M. Elhusseiny, Taher K. Eleiwa, Qais A. Dihan, Muhammad Z. Chauhan, Subhi J. Al’Aref, Richard K. Lee
To evaluate the association between statin use and the risk of ocular hypertension (OHT) and open-angle glaucoma (OAG) among patients with hyperlipidemia across different racial and ethnic subgroups.
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Analysis of Spaceflight-Associated Biometric and Refractive Changes in Astronauts. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-05 Alexander A Svoronos,Cambria S O'Grady,Evan Walker,Natalie A Afshari,Brandon R Macias,Steven S Laurie,Robert N Weinreb,Alex S Huang
PURPOSE To study changes in ocular biometry and refraction in the largest cohort to date of astronauts who have experienced long-duration spaceflight on the International Space Station (ISS). DESIGN A prospective cohort study. PARTICIPANTS 29 astronauts. METHODS Preflight and postflight cycloplegic refraction and ocular biometry measurements were obtained from 56 eyes among 29 subjects. For each eye
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Comment on: Intraocular lens power calculation—comparing big data approaches to established formulas Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-01 Mohammad Reza Baghiyan Zarchi, Mohammad Erabi, Ali Hosseini
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Response to Comment on: Intraocular Lens Power Calculation-Comparing Big Data Approaches to Established Formulas. Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-04-01 Liam D Redden,Birgit Grubauer,Peter Hoffmann,Achim Langenbucher,Kamran M Riaz,Damien Gatinel,Helga Wagner,Jascha A Wendelstein
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Size Matters Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-31 Sanjay Asrani, Ki Ho Park
To describe the ideal size of a laser iridotomy and to discuss its importance.
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Biomechanical Properties Measured With Dynamic Scheimpflug Analyzer in Myopic Maculopathy Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-31 Kazuki Yashiro, Shuichiro Aoki, Kohdai Kitamoto, Takahiro Arai, Keiko Azuma, Tatsuya Inoue, Ryo Asaoka, Ryo Obata
Corneal biomechanical properties are associated with axial elongation. We aimed to characterize corneal biomechanical properties in highly myopic eyes with myopic maculopathy (MM).
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A Narrative Medicine Approach to Navigating Barriers to the Diagnosis of Pediatric Neurotrophic Keratopathy Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-31 Shadia Tannir, Chilando Mulenga, Khoa Tran, Asim Ali, Charline Boente, Gregory H Borschel
Neurotrophic keratopathy (NK) is a rare disease characterized by the loss of corneal innervation and increased vulnerability to injury. The diagnosis and treatment of NK can be challenging for pediatric patients and their caregivers. This study explores the experiences of caregivers navigating the diagnostic and treatment journey of pediatric patients with neurotrophic keratopathy.
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Malignant Transformation of Ocular Melanocytoma to Uveal Melanoma: A Clinicopathologic Review of Three Novel Unsuspected Cases of a Likely Under-Recognized Phenomenon, With Review of the Literature and Molecular Genetic Data Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-31 Fabliha A. Mukit, Nicole E. Terfloth, Ivana K. Kim, Frances Wu, Anna M. Stagner
To describe three cases of, and review the current knowledge regarding, malignant transformation of ocular melanocytoma (OM) to uveal melanoma (UM).
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Choroidal Vascular Occlusion After Fat Injection Into the Temple Area Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-29 CHUANZHEN ZHENG, CHUNXIU LI, JIE ZHONG
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Comparison of Corneal Power Assessment Methods for True Corneal Power After Myopic Small-Incision Lenticule Extraction Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-28 Xiaoling Fang, Chunxia Yu, Wenwen Xue, Jinhua Tao, Wenbo Yao, Liquan Zhao, Yulan Wang
We sought to compare the accuracy of different corneal curvature parameters in estimating corneal power change in eyes that underwent myopic small-incision lenticule extraction (SMILE).
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National Trends in Central Retinal Artery Occlusion Presentations and Stroke Workup in United States Emergency Department Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-28 Sinan Akosman, Sean M. Yuan, Arnold Leigh, Renxi Li, Renjie Luo, Masumi G. Asahi, Kapil Mishra
To investigate trends in acute central retinal artery occlusion (CRAO) diagnostic assessments and sociodemographic characteristics of patients in the United States (US) emergency department (ED).
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Giant Conjunctival Melanoma Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-27 Chunxiao Wang, Jianjun Gu
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Ocular Features of VEXAS Syndrome: A Systematic Review and Meta-analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-27 Clare Quigley, James Pietris, Terence Ang, Lina Zgaga, Dinesh Selva
To identify and analyze ocular features seen in Vacuoles, E1-ligase, X-linked Auto-inflammatory, Somatic (VEXAS) syndrome.
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Visual and Topographic Outcomes After Corneal Allogeneic Intrastromal Ring Segments for Keratoconus: A Systematic Review and Meta-Analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-27 MAXIMILIAN FRIEDRICH, GERD UWE AUFFARTH, URI SOIBERMAN, VICTOR ARISTIDE AUGUSTIN, RAMIN KHORAMNIA, HYECK-SOO SON
Corneal allogeneic intrastromal ring segments (CAIRS) are a novel therapeutic approach to treat ectatic diseases such as keratoconus and improve visual acuity as well as corneal topography. This analysis aimed to evaluate the visual outcomes and corneal topography changes after CAIRS implantation for keratoconus.
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Correlation Between Length of Interdigitation Zone With Severity and Progression of Diabetic Retinopathy Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-27 Feiyan Liang, Shuya Tao, Yimeng Zhang, Siyuan Liu, Wenyong Huang, Chang He, Shuxin Fan, Xialin Liu
To objectively evaluate the alteration of interdigitation zone (IZ) length in diabetic patients and to determine its relationship with diabetic retinopathy (DR) progression.
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Incidence and Prevalence of Uveitis and Associated Ocular Complications in the United States TriNetX Database Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-27 NILA KIRUPAHARAN, RAYNA F. MARSHALL, MATTHEW D. SPANGLER, KAREN R. ARMBRUST, MEGHAN K. BERKENSTOCK
To analyze the demographics, immunosuppressant use, associated systemic diseases, ocular comorbidities, and incidence and prevalence of uveitis and associated low vision using the United States TriNetX database from 2013-2023.
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Characterization of Visual Field Loss Over 4 Years in the Rate of Progression in USH2A-Related Retinal Degeneration (RUSH2A) Study Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-27 Jacque L. Duncan, Maureen G. Maguire, Lee S. McDaniel, Nicole R. Doucet, Isabelle Audo, Allison R. Ayala, Janet K. Cheetham, Peiyao Cheng, Todd A. Durham, Rachel M. Huckfeldt, Robert B. Hufnagel, K. Thiran Jayasundera, Naheed Khan, Brett Malbin, Ramiro S. Maldonado, Michel Michaelides, Mark E. Pennesi, Christina Y. Weng, Alex Zmejkoski, Shobana Aravind, Hiroshi Ishikawa, David G. Birch, Foundation
To report visual field loss using static perimetry (SP) and kinetic perimetry (KP) over 4 years in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study.
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Short-Term Treatment of Syphilitic Uveitis With Intravitreal Ceftazidime Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-26 Emily C. Davis, Akshay S. Thomas
To review the clinical outcomes of patients with ocular syphilis that were treated in the short-term with intravitreal ceftazidime when definitive treatment with penicillin was delayed due to a variety of extenuating circumstances.
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Association of Age With Glaucoma and Visual Acuity Outcomes 10.5 Years After Unilateral Congenital Cataract Surgery Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-26 Claudia K. Wong, He Forbes, Taylor Kolosky, Urjita Das, Euna Cho, Shaiza Mansoor, Sera Chase, Madi Kore, Moran Roni Levin, Larry Magder, Carolyn Drews-Botsch, Scott R. Lambert, Janet L. Alexander
To determine the association among age, gestational age, glaucoma-related adverse events, and visual acuity following unilateral cataract surgery.
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Chlorhexidine Versus Povidone-Iodine for Intravitreal Injection Antisepsis: A Systematic Review and Meta-Analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-26 Andrew Mihalache, Brendan K. Tao, Ryan S. Huang, Thanansayan Dhivagaran, Marko M. Popovic, Peter J. Kertes, David T. Wong, Bryon R. McKay, Radha P. Kohly, Rajeev H. Muni
While povidone-iodine (PI) is a commonly used antiseptic solution for postinjection endophthalmitis (PIE) prophylaxis, chlorhexidine (CHX) may be better tolerated by patients. This systematic review and meta-analysis aims to comprehensively compare the efficacy and safety of CHX and PI for PIE prophylaxis.
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Negative Pressure Application by the Ocular Pressure Adjusting Pump to Lower Intraocular Pressure in Normal-Tension Glaucoma: HERCULES Study Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-25 Tanner J. Ferguson, Thomas W. Samuelson, Leon Herndon, Daniel C. Terveen, Jason Bacharach, Jacob W. Brubaker, John P. Berdahl, Nathan M. Radcliffe
To evaluate the safety and intraocular pressure (IOP)-lowering efficacy of the ocular pressure adjusting pump in subjects with normal-tension glaucoma (NTG).
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Colour Doppler and Contrast-Enhanced Ultrasound Characteristics in Degenerative Retinoschisis and Retinal Detachment Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-25 JAI PARIS, CARMELO MACRI, YONG MIN LEE, MATTHEW LE, FADY SAMMOUH, MEEGAN GUN, WANYIN LIM, WENG ONN CHAN
To investigate and compare the characteristics of colour Doppler ultrasound (CDUS) and contrast-enhanced ultrasound (CEUS) in degenerative retinoschisis (RS) and rhegmatogenous retinal detachment (RD).
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Population-Based Performance of Inflammatory Markers in Giant Cell Arteritis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-24 CLARA M. CASTILLEJO BECERRA, CYNTHIA S. CROWSON, HANNAH E. LANGENFELD, DEENA TAJFIROUZ, KEVIN D. CHODNICKI, MATTHEW J. KOSTER, KENNETH J. WARRINGTON, JOHN J. CHEN
To determine the population-based sensitivities and specificities of various inflammatory markers for the diagnosis of GCA.
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Telomere Biology Disorders: Microvascular Abnormalities on Optical Coherence Tomography Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-24 NATASHA F.S. DA CRUZ, JESSE D. SENGILLO, CATHERIN I. NEGRON, AUDINA M. BERROCAL
Telomere biology disorders (TBDs) are inherited conditions caused by telomere dysfunction, impacting systemic and ocular health. We aim to explore the role of optical coherence tomography angiography (OCTA) in identifying retinal microvascular abnormalities in TBDs.
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Adherence and Persistence on Prostaglandin Analogues for Glaucoma: A Systematic Review and Meta-Analysis Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-18 Christophe Baudouin, Jonathan S. Myers, Sarah H. Van Tassel, Nina A. Goyal, Jose Martinez-de-la-Casa, Alvin Ng, Jennifer S. Evans
To systematically review, synthesize and quantify studies reporting patterns of adherence and persistence with prostaglandin analogues (PGAs) in order to comprehensively understand real-world treatment behavior among patients with glaucoma who are prescribed PGAs. These data can inform the decision between a glaucoma therapy based on either topical PGA medications or procedural PGA-based intervention
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Drugs Associated With Floppy Iris Syndrome: A Real-World Population-Based Study Am. J. Ophthalmol. (IF 4.1) Pub Date : 2025-03-18 Moiz Lakhani, Angela T.H. Kwan, Andrew Mihalache, Marko M. Popovic, Bernard Hurley, Rajeev H. Muni
Intraoperative floppy iris syndrome (IFIS) is associated with an increased rate of severe intraoperative complications and greater visual morbidity during cataract surgery, particularly in females. To date, no postmarketing pharmacovigilance study has comprehensively examined all FDA-approved drugs for their association with IFIS development or explored potential sex differences. Understanding the