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A Quantitative Analysis on Depictions of Chronic Pain Generated via DALL-E 3, a Text-to-Image Artificial Intelligence Tool. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Morgan King,Serena Zahra,Ethan Patterson
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Preoperative Electroencephalography Biomarkers to Identify Children at Risk for Emergence Delirium. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Xuan Li,Dezhao Liu,Niannian Chen,Zheng Li,Xiaoli Li,Tianyi Zhou
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Genome-wide Study on Propofol Requirements: Reply. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Sirkku Ahlström,Hanna Granroth-Wilding,Paula Reiterä,Klaus Olkkola,Ritva Jokela,Mari Kaunisto,Eija Kalso
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Anesthesia Workforce Supply and Demand Imbalance: Comment. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 K Elliott Higgins,Jina Sinskey,Amy E Vinson
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Genome-wide Study on Propofol Requirements: Comment. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Thomas W Schnider,Talmage D Egan,Charles F Minto
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Intersections of Anesthesiology and Psychiatry: Reply. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Connor T A Brenna,Benjamin I Goldstein,Carlos A Zarate,Beverley A Orser
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Solid-organ Transplant Safety in Malignant Hyperthermia: Can Halogenated Anesthetics Be Transferred from Donors to Recipients? Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Calim Neder Neto,Mariana Fontes Lima Neville,Beatriz Lara Siqueira Santos,Albert Urwyler,Helga Cristina Almeida da Silva
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Intersections of Anesthesiology and Psychiatry: Comment. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Alexander Sartorius,Sebastian Karl,Christoph Janke,Grietje Beck
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Intersections of Anesthesiology and Psychiatry: Comment. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Randall T Espinoza,Charles H Kellner,William Vaughn McCall
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Anesthesia Workforce Supply and Demand Imbalance: Reply. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Amr Abouleish,Mary Dale Peterson,Maxime Cannesson,Oluwaseun Akeju,James P Rathmell,Daniel J Cole
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Liposomal Bupivacaine for Nerve Blockade: Comment. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Shuyuan Gan,Fangping Bao,Diansan Su
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Liposomal Bupivacaine for Nerve Blockade: Reply. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Peter Marhofer,Markus Zadrazil
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Do Not Miss the Critical Window during Esophagogastroduodenoscopy. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Qingyu Shi,Chong Chen,Lina Yu,Min Yan
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Optimizing Perioperative Extracorporeal Cardiopulmonary Resuscitation Outcomes: Activate Early and Select Carefully. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Michael Mazzeffi,Akram Zaaqoq,Nicholas Teman
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Perioperative Covert Stroke: Acutely Asymptomatic but Not Benign. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 P J Devereaux,Maura Marcucci
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Chewing Gum: A Viable Option as a Rescue Therapy for Postoperative Nausea and Vomiting? Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Mi Wang,Tong J Gan
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Covert Operation: On the Hunt for Periop Stroke. Anesthesiology (IF 9.1) Pub Date : 2025-02-11 Sasa Rajsic,Holly B Ende,Jonathan P Wanderer
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Neuromuscular Blockade and Antagonism in Patients with Renal Impairment: A Multicenter Retrospective Cross Sectional Study. Anesthesiology (IF 9.1) Pub Date : 2025-02-10 Rania Elkhateb,Davis L Campbell,Xinyi Zhao,Graciela Mentz,Nadir El Sharawi,Sathish Kumar,Jill M Mhyre,Sachin Kheterpal,Douglas A Colquhoun
BACKGROUND Current practice guidelines do not address the use of neuromuscular blocking and antagonism agents in patients with renal impairment. The FDA label for sugammadex advises against use in patients with severe renal impairment (eGFR < 30 ml/min). Using a multicenter electronic health record registry, we sought to understand the modern use of neuromuscular blockade and antagonism agents in patients
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Leading with Harmony: Lessons in Leadership from Music Theory for Anesthesiologists. Anesthesiology (IF 9.1) Pub Date : 2025-02-10 Rafael Ortega,Soobin Song
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Periacetabular Osteotomy Multimodal Pain Control Using Erector Spinae Plane vs Epidural Catheter: A Retrospective Cohort Analysis. Anesthesiology (IF 9.1) Pub Date : 2025-02-07 Anna K Fiedler,Jacob J Siahaan,Alexis H Aboulafia,Angel A Ham,Alfred A Mansour
BACKGROUND Periacetabular osteotomy (PAO) is an established treatment for symptomatic developmental hip dysplasia. Epidural analgesia is traditionally used for perioperative pain management but may have negative secondary effects, including distal motor and sensory deficits, and hypotension which delays rehabilitation and prolongs discharge. One alternative is Erector Spinae Plane Block (ESPB), an
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Airway Injury during Double-lumen Endotracheal Intubation. Anesthesiology (IF 9.1) Pub Date : 2025-02-07 Elisa C Walsh,Paul H Alfille,Xiaodong Bao
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Comparative methods to predict redosing of bupivacaine and ropivacaine in truncal catheters. Anesthesiology (IF 9.1) Pub Date : 2025-02-05 Brittani Bungart,Lana Joudeh,Eric S Schwenk,Christopher Chiang,Michael R Fettiplace
BACKGROUND Despite the frequent use of ropivacaine and bupivacaine, there is limited guidance on redosing of these medications following an initial bolus. Intermittent redosing is a clinical practice in the setting of nerve catheters, often utilizing large doses. Comparatively, theoretical elimination rates are available from pharmacokinetic studies, providing estimates on total body content of these
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Measuring Well-Being Influencers: Development and Validation of the WISH Inventory. Anesthesiology (IF 9.1) Pub Date : 2025-02-03 K Elliott Higgins,Theodora Wingert,Elizabeth W Duggan,Maxwell Mansolf,Jose Hernandez Carcamo,Christine Park
BACKGROUND Improving healthcare professional well-being and reducing burnout requires improving work ecosystems and cultures. Current well-being metrics focus on distal outcomes within individuals (e.g., professional fulfillment or burnout). In this study, we developed and evaluated the performance of an inventory measuring perceptions of modifiable workplace dimensions-termed influencers-that shape
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The Efficacy of Cryoneurolysis on Chronic Pain in Patients with Knee Osteoarthritis; A Double-blinded Randomized Controlled Sham Trial. Anesthesiology (IF 9.1) Pub Date : 2025-01-30 Niels-Peter Brøchner Nygaard,Carsten Koch-Jensen,Henrik Bjarke Vaegter,Niels Wedderkopp,Morten Blichfeldt-Eckhardt,Bibi Gram
BACKGROUND The objective was to investigate if cryoneurolysis were superior to sham in reducing pain intensity in patients with chronic knee osteoarthritis. We hypothesized that cryoneurolysis was an effective and safe therapy to reduce chronic pain in patients with knee osteoarthritis. METHODS The study was a randomized, double-blind, sham-controlled. Eighty-seven patients with chronic knee osteoarthritis
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Accuracy of two-compartment modelling of gas exchange with ventilation-perfusion mismatch in inhalational anesthesia. Anesthesiology (IF 9.1) Pub Date : 2025-01-30 Philip J Peyton
BACKGROUND Multi-compartment computer models of heterogeneity in alveolar ventilation-perfusion ratios (VA/Q scatter) across the lung explain the significant alveolar-arterial (A-a) partial pressure gradients and associated alveolar dead-space fractions (VDA/VA) seen in anesthetized patients for both carbon dioxide and for anesthetic gases of different blood solubilities. However, the accuracy of a
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Tranexamic dosing for major joint arthroplasty in adult patients with chronic kidney disease: A pharmacokinetic study and new dosing regimen. Anesthesiology (IF 9.1) Pub Date : 2025-01-29 Qi Yang,Jim He,H Benson Peng,Binyu Wen,Christopher Idestrup,Bheeshma Ravi,John Murnaghan,Aaron McCarron,Hana Hadley,Hansoo Shin,Lilia Kaustov,Jeremy Wong,Yulia Lin,Stephen Choi,Beverley A Orser,Martin Van der Vyver,Ben Safa,K Sandy Pang,Angela Jerath
BACKGROUND Tranexamic acid is an anti-fibrinolytic agent routinely used during hip and knee joint replacement surgery to minimize bleeding. Chronic kidney disease is a common chronic health problem seen among adults requiring major arthroplasty surgery. Tranexamic acid is renally cleared and may accumulate in chronic kidney disease. Optimal tranexamic acid dosing and dose adjustment for chronic kidney
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Somatostatin-expressing neurons in the medial prefrontal cortex promote sevoflurane anesthesia in mice. Anesthesiology (IF 9.1) Pub Date : 2025-01-27 Aichen Tang,Mao Xu,Xizu Chen,Juan Liu,Jiamin Wang,Ying Wang,Shuang Cai,Yue Shu,Danxu Zheng,Tian Yu,Yuan Wang,Tianyuan Luo,Shouyang Yu
BACKGROUND The medial prefrontal cortex plays a crucial role in regulating consciousness. However, the specific functions of its excitatory and inhibitory networks during anesthesia remain uncertain. Here we explored the hypothesis that somatostatin interneurons in the medial prefrontal cortex enhance the effects of sevoflurane anesthesia by increasing GABA transmission to pyramidal neurons. METHODS
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Longitudinal Reliability of Milestones Learning Trajectories during Anesthesiology Residency. Anesthesiology (IF 9.1) Pub Date : 2025-01-27 Ting Sun,Yoon Soo Park,Fei Chen,Sean O Hogan,Pedro Tanaka
BACKGROUND Longitudinal Milestones data reported to the Accreditation Council for Graduate Medical Education (ACGME) provide a structured framework for assessing the developmental progression of residents in key competencies and subcompetencies. This study aims to investigate the previously underexplored longitudinal reliability of Milestones data, with the goal of identifying patterns in learning
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Impact of under-assisted ventilation on diaphragm function and structure in a porcine model. Anesthesiology (IF 9.1) Pub Date : 2025-01-24 Mathieu Capdevila,Joris Pensier,Audrey De Jong,Boris Jung,July Beghin,Thomas Laumon,Yassir Aarab,Lucas Deffontis,Thomas Sfara,Ambre Cuny,Julie Carr,Nicolas Molinari,Jean-Yves Le Guennec,Fabrice Raynaud,Stefan Matecki,Laurent Brochard,Alain Lacampagne,Samir Jaber
BACKGROUND Long-term controlled mechanical ventilation (CMV) in intensive care unit (ICU) induces ventilatory-induced-diaphragm-dysfunction (VIDD). The transition from CMV to assisted mechanical ventilation is a challenge that requires clinicians to balance over-assistance and under-assistance. While the effects of over-assistance on the diaphragm are well known, we aimed to assess the impact of under-assistance
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Cytokine Hemoadsorption versus Standard Care in Cardiac Surgery Using the Oxiris® Membrane: the OXICARD single center randomized trial. Anesthesiology (IF 9.1) Pub Date : 2025-01-21 Osama Abou-Arab,Pierre Huette,Azrat Ibrahima,Christophe Beyls,Guillaume Bayart,Mathieu Guilbart,Adrien Coupez,Youssef Bennis,Aurélie Navarre,Gaelle Lenglet,Roman Béal,Gilles Touati,Thierry Caus,Stéphane Bar,Estelle Josse,Maxime Nguyen,Hervé Dupont,Brigitte Gubler,Saïd Kamel,Momar Diouf,Yazine Mahjoub
BACKGROUND Cardiac surgery can lead to dysregulation with a pro-inflammatory state, resulting in adverse outcomes. Hemadsorption using the AN69 membrane (Oxiris membrane) has the properties to chelate inflammatory cytokines. We hypothesized that in patients at high risk of inflammation, the use of the Oxiris membrane could decrease inflammation, preserve endothelial function, and improve postoperative
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Failed Neuroprotection Trials: An Evaluation of Complexity and Clinical Trial Design. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 W Andrew Kofke,Todd A Miano
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Telltale Hearts: A Public Health Doctor, His Patients, and the Power of Story. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Robert E Johnstone
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Volatile Anesthetic Intensive Care Unit Sedation: Reply. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Brian O'Gara,Christopher Hughes
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Remifentanil and Dexmedetomidine Treat Hypertension: Comment. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Pradipta Bhakta,Habib Md Reazaul Karim,Ehtesham Khan,Mohan Mugawar
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Volatile Anesthetic Intensive Care Unit Sedation: Comment. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Henry Rosenberg,Charles Watson,Marilyn Green Larach
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Fibrinolysis on Extracorporeal Membrane Oxygenation: Reply. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Julie Helms,Ferhat Meziani,Eduardo Angles-Cano
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Fibrinolysis on Extracorporeal Membrane Oxygenation: Comment. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 François Labaste,Agnes Ribes,Alexandre Mansour,Fanny Vardon-Bounes
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Remifentanil and Dexmedetomidine Treat Hypertension: Reply. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Rui Dong,Fen Li,Zhenhua Zeng,Chunbo Chen,Hong Yang
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Perioperative Management of Patients with Preeclampsia: A Comprehensive Review. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Alicia T Dennis,Annie Xin,Michaela K Farber
Preeclampsia is a common condition of pregnancy characterized by hypertension complicated by cerebral, cardiac, hepatic, renal, hematologic, and placental dysfunction. Patients with preeclampsia frequently undergo cesarean delivery, the most common major surgical procedure in the world. They represent a high-risk perioperative cohort suffering significant preventable morbidity and mortality. This review
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Comparison of Intravenous Oxycodone and Sufentanil on Propofol Requirement during Hysteroscopy: A Double-blind, Dose-Response Study. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Xiu-Bo Lv,Yan-Hong Zhou,Shu-Xi Li,Jin-Peng Fu,Li- Xing,Jian-Jun Shen,Dong-Xin Wang,Xin-Zhong Chen,Li-Li Xu
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Trends in Neuraxial Labor Analgesia Utilization by Race and Ethnicity among Nulliparous Individuals Undergoing Spontaneous Vaginal Delivery, United States, 2007 to 2022. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Emily Stockert,Sara Siadat,Brian T Bateman,Eva Martinez,Alexander J Butwick,Stephanie A Leonard
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Safe or Skip? Association Between Intraoperative Midazolam in Elderly Patients and Rates of Postop Delirium. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Andrew Klein,Holly B Ende,Jonathan P Wanderer
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Preoperative Standardized Phase Angle Is Associated with Any and 30-Day Medical-related Postoperative Complications among Colorectal and Lung Surgical Patients: A Retrospective Analysis. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Natalia Tomborelli Bellafronte,Sarah Atoui,Francesco Carli,A Sender Liberman,Thomas Schricker,Chelsia Gillis
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Secondary Analyses: The Perils of Making Do. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 David O Warner,Randall P Flick
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Hemodynamics Effects of the Left Lateral Decubitus Position in Pregnancy as Assessed by Simultaneous Internal Jugular and Common Carotid Doppler Ultrasound. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Leonard J Soloniuk,Christopher Baker,William Mao
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Building a Better Base for Keeping Buprenorphine on Board for Surgery. Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Mark C Bicket,Thuy Nguyen
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Central Venous Catheter-associated Venous Thrombosis in Neonates: "Seek and You Shall Find". Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Paul G Davies
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The Amygdala: Another Switch That Controls Consciousness? Anesthesiology (IF 9.1) Pub Date : 2025-01-14 Aeyal Raz,Ken Solt
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Mapping the Darkness: The Visionary Scientists Who Unlocked the Mysteries of Sleep. Anesthesiology (IF 9.1) Pub Date : 2025-01-13 Kathryn E McGoldrick
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How an Unusual Trade-off Could Save a Life in Gaza. Anesthesiology (IF 9.1) Pub Date : 2025-01-13 Stefano Di Bartolomeo
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TAK-925 (danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-Induced Respiratory Depression and Sedation Without Affecting Analgesia in Healthy Adult Males. Anesthesiology (IF 9.1) Pub Date : 2025-01-13 Maarten van Lemmen,Albert Dahan,Yaming Hang,Simone C Jansen,Hong Lu,Melissa Naylor,Tina Olsson,Sarah Sheikh,Danielle Sullivan,Max Tolkoff,Rutger van der Schrier,Monique van Velzen,Philipp von Rosenstiel,Rebecca L Wu,Seetha Meyer
BACKGROUND Orexin neuropeptides help regulate sleep/wake states, respiration, and pain. However, their potential role in regulating breathing, particularly in perioperative settings, is not well understood. TAK-925 (danavorexton), a novel, orexin receptor 2-selective agonist, directly activates neurons associated with respiratory control in the brain and improves respiratory parameters in rodents undergoing
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Preliminary Development and Validation of Automated Nociception Recognition Using Computer Vision in Perioperative Patients. Anesthesiology (IF 9.1) Pub Date : 2025-01-13 Timothy A Heintz,Anusha Badathala,Avery Wooten,Cassandra W Cu,Alfred Wallace,Benjamin Pham,Arthur W Wallace,Julien Cobert
BACKGROUND Effective pain recognition and treatment in perioperative environments reduce length of stay and decrease risk of delirium and chronic pain. We sought to develop and validate preliminary computer vision-based approaches for nociception detection in hospitalized patients. METHODS Prospective observational cohort study using red-green-blue camera detection of perioperative patients. Adults
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Does Management of Postoperative Nausea and Vomiting Differ by Patient Demographics? An Evaluation of Perioperative Anesthetic Management - An Observational Study. Anesthesiology (IF 9.1) Pub Date : 2025-01-09 Kareem V Goldson,Emily Brennan,Brittany N Burton,Abimbola O Faloye,Elizabeth B Habermann,Kristine T Hanson,David O Warner,Mohanad R Youssef,Adam J Milam
BACKGROUND Disparities in postoperative nausea and vomiting (PONV) and its prophylaxis may exist based on race, ethnicity, and socioeconomic status (SES). Our objective was to evaluate whether patients from racial and ethnic minority groups and patients from lower SES backgrounds received less appropriate PONV prophylaxis and experienced higher rates of PONV and post-discharge nausea and vomiting (PDNV)
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Developing an EEG-based model to predict awakening after cardiac arrest using partial processing with the BIS Engine. Anesthesiology (IF 9.1) Pub Date : 2025-01-09 Samuel B Snider,Bradley J Molyneaux,Anarghya Murthy,Quinn Rademaker,Hafeez Rajwani,Benjamin M Scirica,Jong Woo Lee,Christopher Connor
INTRODUCTION Accurate prognostication in comatose survivors of cardiac arrest is a challenging and high-stakes endeavor. We sought to determine whether internal EEG subparameters extracted by the Bispectral Index (BIS) monitor, a device commonly used to estimate depth-of-anesthesia intraoperatively, could be repurposed to predict recovery of consciousness after cardiac arrest. METHODS In this retrospective
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Protein alterations in patients with delirium after cardiac surgery: An exploratory case-control sub-study of the VISION Cardiac Surgery Biobank. Anesthesiology (IF 9.1) Pub Date : 2025-01-09 Jessica Spence,P J Devereaux,Shaheena Bashir,Katheryn Brady,Tao Sun,Matthew T V Chan,Chew Yin Wang,Andre Lamy,Richard P Whitlock,William F McIntyre,Emilie Belley-Côté,Guillaume Paré,Michael Chong
BACKGROUND Delirium is an acute state of confusion associated with adverse postoperative outcomes. Delirium is diagnosed clinically using screening tools; most cases go undetected. Identifying a delirium biomarker would allow for accurate diagnosis, application of therapies, and insight into causal pathways. To agnostically discover novel biomarkers of delirium, we conducted a case-control sub-study
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Impaired macroscopic CSF flow by sevoflurane in humans - both during and after anesthesia. Anesthesiology (IF 9.1) Pub Date : 2025-01-08 Juliana Zimmermann,Christian Sorg,Leander Müller,Franziska Zistler,Viktor Neumaier,Moritz Bonhoeffer,Andreas Ranft,Daniel Golkowski,Josef Priller,Claus Zimmer,Rüdiger Ilg,Christine Preibisch,Gerhard Schneider,Rachel Nuttall,Benedikt Zott
BACKGROUND According to the model of the glymphatic system, the directed flow of cerebrospinal fluid (CSF) is a driver of waste clearance from the brain. In sleep, glymphatic transport is enhanced, but it is unclear how it is affected by anesthesia. Animal research indicates partially opposing effects of distinct anesthetics but corresponding results in humans are lacking. Thus, this study aims to
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Hemodynamic Management guided by the Hypotension Prediction Index in Abdominal Surgery: A Multicenter Randomized Clinical Trial. Anesthesiology (IF 9.1) Pub Date : 2025-01-02 Javier Ripollés-Melchor,José L Tomé-Roca,Andrés Zorrilla-Vaca,César Aldecoa,María J Colomina,Eva Bassas-Parga,Juan V Lorente,Alicia Ruiz-Escobar,Laura Carrasco-Sánchez,Marc Sadurni-Sarda,Eva Rivas,Jaume Puig,Elizabeth Agudelo-Montoya,Sabela Del Rio-Fernández,Daniel García-López,Ana B Adell-Pérez,Antonio Guillen,Rocío Venturoli-Ojeda,Bartolomé Fernández-Torres,Ane Abad-Motos,Irene Mojarro,José L Garrido-Calmaestra
BACKGROUND Postoperative acute kidney injury (AKI) after major abdominal surgery leads to poor outcomes. The Hypotension Prediction Index (HPI) may aid in managing intraoperative hemodynamic instability. This study assessed if HPI-guided therapy reduces moderate-to-severe AKI incidence in moderate-to-high-risk elective abdominal surgery patients. METHODS This multicenter randomized trial was conducted
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Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Double-blind Randomized Controlled Trial. Anesthesiology (IF 9.1) Pub Date : 2024-12-27 Qirui Zhang,Xuyang Ye,Shuqing Shi,Songhua Zhou,Daqing Ma,Wen Ouyang,Jianbin Tong,Yuan Le
BACKGROUND Postoperative nausea and vomiting (PONV) are common complications after gynecological laparoscopic surgery. Pyridoxine has been recommended as a first-line drug to prevent and treat nausea and vomiting during pregnancy; however, its efficacy in preventing PONV remains unclear. METHODS Patients of 18 to 65 years old, who received elective gynecological laparoscopic surgery under general anesthesia