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The Dementia SomaSignal Test (dSST): A plasma proteomic predictor of 20-year dementia risk Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Michael R. Duggan, Clare Paterson, Yifei Lu, Hannah Biegel, Heather E. Dark, Jenifer Cordon, Murat Bilgel, Naoto Kaneko, Masaki Shibayama, Shintaro Kato, Makio Furuichi, Iwao Waga, Keita Hiraga, Masahisa Katsuno, Yukiko Nishita, Rei Otsuka, Christos Davatzikos, Guray Erus, Kelsey Loupy, Melissa Simpson, Alexandria Lewis, Abhay Moghekar, Priya Palta, Rebecca F. Gottesman, Susan M. Resnick, Josef Coresh
There is an unmet need for tools to quantify dementia risk during its multi-decade preclinical/prodromal phase, given that current biomarkers predict risk over shorter follow-up periods and are specific to Alzheimer's disease.
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Alzheimer's disease patients have smaller venous drainage system compared to cognitively healthy controls Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Keshet Pardo, Vadim Khasminsky, Ophir Keret, Felix Benninger, Ilan Goldberg, Ilan Shelef, Eitan Auriel, Amir Glik
One of the pathological hallmarks of Alzheimer's disease (AD) is the accumulation of amyloid beta 42 (Aβ42). Decreased venous drainage may enhance Aβ42 accumulation. We aimed to compare venous cross-sectional area (CSA) of AD patients to cognitively healthy controls.
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Mapping reactive astrogliosis in Parkinson's brain with astroglial tracers BU99008 and Deprenyl: New insights from a multi-marker postmortem study Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Filipa M. Rocha, Avishek Roy, Mukesh Varshney, Amit Kumar
Despite significant astrocytic involvement in Parkinson's disease (PD), the knowledge regarding the role of reactive astrogliosis is still at the surface level; largely due to lack of specific biomarkers to track these processes. Novel astroglial PET-tracers BU99008 and Deprenyl, hold immense potential for visualizing reactive astrogliosis in PD. However, they have not been thoroughly investigated
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Prevalence of subjective cognitive decline and its association with physical health problems among urban community dwelling elderly population in South India Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Jayakumar Menon, Suvarna Jyothi Kantipudi, Stanley Vinoth, Jyothsna Devi Kuchipudi
No studies in India have explored subjective cognitive decline (SCD), a hallmark of stage II of preclinical Alzheimer's disease. This study aims to assess the prevalence and correlates of SCD in a South Indian, urban, elderly population.
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Remote cognitive tests predict neurodegenerative biomarkers in the Insight 46 cohort Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Martina Del Giovane, Valentina Giunchiglia, Ziyuan Cai, Marguerite Leoni, Rebecca Street, Kirsty Lu, Andrew Wong, Maria Popham, Jennifer M. Nicholas, William Trender, Peter J. Hellyer, Thomas D. Parker, Heidi Murray-Smith, David M. Cash, Josephine Barnes, Carole H. Sudre, Paresh A. Malhotra, Sebastian J. Crutch, Marcus Richards, Adam Hampshire, Jonathan M. Schott
Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early cognitive changes. We explored the relationship between neurodegenerative biomarkers and cognition in cognitively normal individuals.
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Tracer kinetic model detecting heterogeneous blood–brain barrier permeability to water and contrast agent in Alzheimer's disease and dementia with Lewy bodies Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Ziming Xu, Yong Ji, Chen Wen, Jinghuan Gan, Zhichao Chen, Rui Li, Xiaoqi Lin, Jiaqi Dou, Yajie Wang, Shuai Liu, Zhihong Shi, Hao Wu, Hao Lu, Huijun Chen
Blood–brain barrier (BBB) breakdown is essential in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), whereas the variability in BBB permeability to water and contrast agent is less clear.
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Long non-coding RNAs as key regulators of neurodegenerative protein aggregation Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Qi Xu, Dan Liu, Ling-Qiang Zhu, Ying Su, He-Zhou Huang
The characteristic events in neurodegenerative diseases (NDDs) encompass protein misfolding, aggregation, accumulation, and their related cellular dysfunction, synaptic function loss. While distinct proteins are implicated in the pathological processes of different NDDs, the process of protein misfolding and aggregation remains notably similar across various conditions. Specifically, proteins undergo
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A brain DNA co-methylation network analysis of psychosis in Alzheimer's disease Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Morteza Kouhsar, Luke Weymouth, Adam R. Smith, Jennifer Imm, Claudia Bredemeyer, Yehani Wedatilake, Ali Torkamani, Sverre Bergh, Geir Selbæk, Jonathan Mill, Clive Ballard, Robert A. Sweet, Julia Kofler, Byron Creese, Ehsan Pishva, Katie Lunnon
The presence of psychosis in Alzheimer's disease (AD) is suggested to be associated with distinct molecular and neuropathological profiles in the brain.
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Parallel changes in cognition, neuropsychiatric symptoms, and amyloid in cognitively unimpaired older adults and those with mild cognitive impairment Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Alyssa N. De Vito, Zachary J. Kunicki, Hannah E. Joyce, Edward D. Huey, Richard N. Jones
Alzheimer's disease (AD) diagnosis centers on cognitive impairment despite other early indicators like neuropsychiatric symptoms (NPSs) and amyloid beta (Aβ) accumulation. This study examined how cognition, NPS, and Aβ changes are interrelated over time in individuals without dementia.
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White matter injury, plasma Alzheimer's disease, and neurodegenerative biomarkers on cognitive decline in community-dwelling older adults: A 10-year longitudinal study Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Qili Hu, Xiaowen Zhou, Zhenxu Xiao, Qianhua Zhao, Ding Ding, Jun Zhang
This study aimed to investigate the synergistic impact of white matter injury, Alzheimer's disease, and neurodegenerative pathology on long-term cognitive decline and dementia risk in older adults.
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Age at menopause and cognitive function and decline among middle-aged and older women in the China Health and Retirement Longitudinal Study, 2011–2018 Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Muqi Guo, Yingyan Wu, Alden L. Gross, Carrie Karvonen-Gutierrez, Lindsay C. Kobayashi
Chinese women experience higher dementia rates than men, yet sex-specific risk factors are understudied. We examined how menopause age affects cognitive function and decline in aging Chinese women.
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SSRIs reduce plasma tau and restore dorsal raphe metabolism in Alzheimer's disease Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Dylan J. Terstege, Shaista Jabeen, , Liisa A. M. Galea, Jonathan R. Epp, Derya Sargin
Tau pathology impacts neurodegeneration and cognitive decline in Alzheimer's disease (AD), with the dorsal raphe nucleus (DRN) being among the brain regions showing the earliest tau pathology. As a serotonergic hub, DRN activity is altered by selective serotonin reuptake inhibitors (SSRIs), which also have variable effects on cognitive decline and pathology in AD.
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Influence of alpha-synuclein on glucose metabolism in Alzheimer's disease continuum: Analyses of α-synuclein seed amplification assay and FDG-PET Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Elijah Mak, Scott A. Przybelski, Heather J. Wiste, Angela J. Fought, Christopher G. Schwarz, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, Ronald C. Petersen, Bradley F. Boeve, John T. O'Brien, Kejal Kantarci
We investigated the association between alpha-synuclein (α-syn) pathology and brain glucose metabolism across the cognitive spectrum of Alzheimer's disease (AD) co-pathologies.
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Transcriptome analysis of early- and late-onset Alzheimer's disease in Korean cohorts Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Sang-Won Han, Jiyun Hwang, Tamina Park, Jung-Min Pyun, Joo-Yeon Lee, Jeong Su Park, Paula J. Bice, Shiwei Liu, Sunmin Yun, Jibin Jeong, Shannon L. Risacher, Andrew J. Saykin, Min Soo Byun, Dahyun Yi, Joohon Sung, Dong Young Lee, SangYun Kim, Kwangsik Nho, Young Ho Park
The molecular mechanisms underlying early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) remain incompletely understood, particularly in Asian populations.
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Predicting survival rate by plasma biomarkers and clinical variables in syndromes associated with frontotemporal lobar degeneration Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-12 Maria Sofia Cotelli, Barbara Tarantino, Kübra Tan, Hanna Huber, Valentina Cantoni, Valeria Bracca, Roberto Gasparotti, Enrico Premi, Giancarlo Logroscino, Andrea L. Benedet, Kaj Blennow, Henrik Zetterberg, Mario Grassi, Nicholas J. Ashton, Barbara Borroni
Modeling the survival rate in syndromes associated with frontotemporal lobar degeneration (FTLD) is essential to assess disease trajectories.
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A multi-omic single-cell landscape of the aging mouse ovary Geroscience (IF 5.3) Pub Date : 2025-02-11 Jian Zhang, Shunze Jia, Zehua Zheng, Lanrui Cao, Jingyi Zhou, Xudong Fu
The ovary is one of the first organs in humans to exhibit age-related functional impairments. As an organ composed of diverse heterogeneous cell types, the ovary exhibits cell-type-specific changes during the aging process, ultimately leading to a decline in female fertility. Investigating the molecular mechanisms of ovarian aging is crucial for understanding age-related fertility dysfunction in females
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Mapping of catecholaminergic denervation, neurodegeneration, and inflammation in 6-OHDA-treated Parkinson’s disease mice npj Parkinsons Dis. (IF 6.7) Pub Date : 2025-02-11 Matteo Santoro, Rachel K. Lam, Sarah E. Blumenfeld, Weiqi Tan, Peter Ciari, Emily K. Chu, Nay L. Saw, Daniel Ryskamp Rijsketic, Jennifer S. Lin, Boris D. Heifets, Mehrdad Shamloo
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Unraveling the link between frailty and Alzheimer’s disease biomarkers in patients with mild cognitive impairment Geroscience (IF 5.3) Pub Date : 2025-02-10 Simona Buscarnera, Marco Canevelli, Giuseppe Bruno, Valentina Garibotto, Giovanni Battista Frisoni, Federica Ribaldi
Alzheimer’s disease (AD) can be identified through biomarkers of amyloid (A) and tau (T) pathology. Frailty, a measure of biological aging, could impact the association between AD neuropathology and its clinical manifestation. We aimed to investigate the relationship between frailty and AD biomarkers among people with mild cognitive impairment (MCI) attending a university memory clinic. Data were collected
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Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2025-02-11 Blanka Rogina, Rozalyn Anderson, Nathan Lebrasseur, Sean Curan, Matthew J Yousefzadeh, Bhaswati Ghosh, Gustavo Duque, Susan Howlett, Steven Austad, Ilja Demuth, Denis Gerstorf, Justin Korfhage, David B Lombard, Peter Abadir, Kaare Christensen, James R Carey, Susan C Alberts, Fernando Campos, Juan Pablo Palavicini, Allyson Palmer, Justice Bell, Nathan Basisty, Rafael de Cabo, Ana Gomes, Vishwa Deep
The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic and non-genetic interventions have been described, which successfully extend healthspan and lifespan in different species. Furthermore, a number of clinical trials have been evaluating the feasibility
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The role of protective genetic variants in modulating epigenetic aging Geroscience (IF 5.3) Pub Date : 2025-02-10 Yosra Bejaoui, Luma Srour, Abeer Qannan, Junko Oshima, Chadi Saad, Steve Horvath, Hamdi Mbarek, Nady El Hajj
Several progeroid syndromes’ causative mutations have been linked to epigenetic age acceleration as measured via several epigenetic clocks. At the same time, several protective variants have also been discovered that can reduce the risk of developing certain age-related disorders. However, the impact of these protective variants on epigenetic aging has not been well elucidated. Our research, which
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Impact of Mlkl or Ripk3 deletion on age-associated liver inflammation, metabolic health, and lifespan Geroscience (IF 5.3) Pub Date : 2025-02-10 Sabira Mohammed, Phoebe Ohene-Marfo, Chao Jiang, Zongkai Peng, Nidheesh Thadathil, Albert Tran, Evan Nicklas, Shylesh Bhaskaran, Dawei Wang, Ramasamy Selvarani, Amit Singh, Zhibo Yang, Nagib Ahsan, Sathyaseelan S. Deepa
Chronic, low-grade inflammation is a hallmark of aging and various age-related diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). The prevalence of metabolic dysfunction-associated steatohepatitis (MASH), an advanced form of MASLD, increases with age and contributes to morbidity and mortality among the elderly. This study investigates the role of necroptosis, a programmed
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Comparison between the effect of mid-late-life high-intensity interval training and continuous moderate-intensity training in old mouse hearts J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2025-02-10 Qiaowei Li, Qin Liu, Zhong Lin, Wenwen Lin, Zhonghua Lin, Feng Huang, Pengli Zhu
The impact of mid-late-life exercise on the aging heart remains unclear, particularly the effects of high-intensity interval training (HIIT) and continuous moderate-intensity training (CMIT). This study was the first to examine cardiac function, tissue characteristics, electrical remodeling, mitochondrial morphology and homeostasis in old mice subjected to CMIT or HIIT, compared to untrained controls
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Obesity, sarcopenia, sarcopenic obesity and hypertension: mediating role of inflammation and insulin resistance J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2025-02-07 Yuanlin Zou, Hua Ye, Ziqing Xu, Qian Yang, Jicun Zhu, Tiandong Li, Yifan Cheng, Yongjian Zhu, Junxi Zhang, Yacong Bo, Peng Wang
Background This study aimed to assess the association between obesity, sarcopenia, and sarcopenic obesity with hypertension and to explore the potential mediation of inflammation indicators and insulin resistance. Methods Data from the UK Biobank, a large-scale prospective cohort, were utilized. Obesity was defined using percentage of fat mass, while sarcopenia was defined as low muscle mass and low
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In vivo medical imaging for assessing geroprotective interventions in humans Geroscience (IF 5.3) Pub Date : 2025-02-06 Jonas E. Svensson, Martin Schain, Pontus Plavén-Sigray
There is a growing interest in developing drugs with a general geroprotective effect, aimed at slowing down aging. Several compounds have been shown to increase the lifespan and reduce the incidence of age-related diseases in model organisms. Translating these results is challenging, due to the long lifespan of humans. To address this, we propose using a battery of medical imaging protocols that allow
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Workload and clinical impact of MRI-based extension of reperfusion therapy time window in acute ischaemic stroke—a prospective single-centre study Geroscience (IF 5.3) Pub Date : 2025-02-06 Tímea Tünde Takács, Rita Magyar-Stang, Szabolcs Szatmári, Ildikó Sipos, Katalin Saftics, Ádám József Berki, Sándor Évin, Dániel Bereczki, Csaba Varga, Nóra Nyilas, István Bíró, Péter Barsi, Máté Magyar, Pál Maurovich-Horvat, Péter Pál Böjti, Máté Pásztor, István Szikora, Sándor Nardai, Bence Gunda
Current European Stroke Organisation (ESO) guidelines recommend extended time window reperfusion therapies (4.5–9 h for thrombolysis, 6–24 h for thrombectomy) based on advanced imaging. However, the workload and clinical benefit of this strategy on a population basis are not known. To determine the caseload, treatment rates, and outcomes in the extended as compared to the standard time windows. All
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Massive changes in gene expression and their cause(s) can be a unifying principle in the pathobiology of Alzheimer's disease Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-06 Paul D. Coleman, Elaine Delvaux, Jeffrey H. Kordower, Ashley Boehringer, Carol J. Huseby
Understanding of the biology of Alzheimer's disease (AD) has long been fragmented, with various investigators concentrating on amyloid beta (Aβ) or tau, inflammation, cell death pathways, misfolded proteins, glia, and more. Yet data from multiple authors has repeatedly shown altered expression of myriad genes related to these seemingly disparate phenomena. In 2022, Morgan et al. organized the massive
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Differential roles of Alzheimer's disease plasma biomarkers in stepwise biomarker-guided diagnostics Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-05 Hyemin Jang, Daeun Shin, Heejin Yoo, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J. Ashton, Theresa A. Day, Eun Hye Lee, Jihwan Yun, Duk L Na, Hee Jin Kim, Sung Hoon Kang, Ko Woon Kim, Si Eun Kim, Yeo Jin Kim, Yeshin Kim, Jaeho Kim, Chi-Hun Kim, Min Young Chun, Na Yeon Jung, Soo Hyun Cho, Jun Pyo Kim, Sang Won Seo
This study aimed to investigate the differential roles of various plasma biomarkers in a stepwise diagnostic strategy for Alzheimer's disease (AD).
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Fecal microbiota transplant from long-living Ames dwarf mice alters the microbial composition and biomarkers of liver health in normal mice Geroscience (IF 5.3) Pub Date : 2025-02-04 Sarah A. Ashiqueali, Natalie Hayslip, Diptaraj S. Chaudhari, Augusto Schneider, Xiang Zhu, Blazej Rubis, Corey E. Seavey, Md Tanjim Alam, Ridwan Hussein, Sarah A. Noureddine, Ewelina Golusinska-Kardach, Pawel Pazdrowski, Hariom Yadav, Michal M. Masternak
Aging is associated with intestinal dysbiosis, a condition characterized by diminished microbial biodiversity and inflammation. This leads to increased vulnerability to extraintestinal manifestations such as autoimmune, metabolic, and neurodegenerative conditions thereby accelerating mortality. As such, modulation of the gut microbiome is a promising way to extend healthspan. In this study, we explore
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A cohort study reveals shared and distinct serum metabolic biomarkers for major adverse cardiovascular events in middle-aged and older adults Geroscience (IF 5.3) Pub Date : 2025-02-04 Yi Ren, Bo Chen, Honggang Zhang, Shaoyong Xu
We assessed the association of serum metabolites with the occurrence of major adverse cardiovascular events (MACE) in middle-aged and elderly individuals, explored the value of metabolomics in predicting MACE, and compared the distinctions in MACE risk-related metabolic biomarkers between middle-aged and elderly groups. Among the participants of the UK Biobank who underwent baseline assessment through
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Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adults Geroscience (IF 5.3) Pub Date : 2025-02-05 Colleen Pappas, Christopher E. Bauer, Valentinos Zachariou, T. J. Libecap, Beatriz Rodolpho, Tiffany L. Sudduth, Peter T. Nelson, Gregory A. Jicha, Anika MS Hartz, Xingfeng Shao, Danny J. J. Wang, Brian T. Gold
There is growing interest in studying vascular contributions to cognitive impairment and dementia (VCID) and developing biomarkers to identify at-risk individuals. A combination of biofluid and neuroimaging markers may better profile early stage VCID than individual measures. Here, we tested this possibility focusing on plasma levels of S100 calcium-binding protein B (S100B), which has been linked
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The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho‐tau Round Robin study Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-05 Nicholas J. Ashton, Ashvini Keshavan, Wagner S. Brum, Ulf Andreasson, Burak Arslan, Mathias Droescher, Stefan Barghorn, Jeroen Vanbrabant, Charlotte Lambrechts, Maxime Van Loo, Erik Stoops, Shweta Iyengar, HaYeun Ji, Xiaomei Xu, Alex Forrest‐Hay, Bingqing Zhang, Yuling Luo, Andreas Jeromin, Manu Vandijck, Nathalie Le Bastard, Hartmuth Kolb, Gallen Triana‐Baltzer, Divya Bali, Shorena Janelidze, Shieh‐Yueh
INTRODUCTIONThe Alzheimer's Association Global Biomarker Standardization Consortium conducted a blinded case–control study to learn which phosphorylated tau (p‐tau) assays provide the largest fold‐changes in Alzheimer's disease (AD) versus non‐AD and show commutability in measuring patient samples and candidate certified reference materials (CRMs).METHODSThirty‐three different p‐tau assays measured
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The genetic landscape of early‐onset Alzheimer's disease in China Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-05 Wei Qin, Fang‐Yu Li, Wen‐Ying Liu, Ying Li, Shu‐Man Cao, Yi‐Ping Wei, Yan Li, Qi Wang, Qi‐Geng Wang, Jian‐Ping Jia
INTRODUCTIONResearch on somatic and germline mutations in Chinese individuals with early‐onset Alzheimer's disease (EOAD) has been limited.METHODSWe conducted whole‐genome sequencing of blood DNA from 108 patients with EOAD and 116 controls. The analysis included somatic and germline mutations across coding and non‐coding regions, mutational signature determination, pathway enrichment identification
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Issue Information Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-05
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Effects of osteoporosis treatment and multicomponent integrated care on intrinsic capacity and happiness among rural community-dwelling older adults: the Healthy Longevity and Ageing in Place (HOPE) randomised controlled trial Age Ageing (IF 6.0) Pub Date : 2025-02-05 Ya-Hui Chang, Chih-Chien Hung, Yen-Yi Chiang, Chiu-Ying Chen, Ling-Chiao Liao, Matthew Huei-Ming Ma, Juey-Jen Hwang, Chih-Cheng Hsu, Chung-Yi Li, Shau-Huai Fu, Chen-Yu Wang
Background Monitoring and improving intrinsic capacity (IC) and well-being are essential for older adults to maintain functional abilities. However, evidence of effective interventions to improve IC and happiness is scarce. This study examined the effects of multicomponent interventions in the Healthy Longevity and Ageing in Place (HOPE) randomised controlled trial on IC and happiness among rural community-dwelling
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Association of motoric cognitive risk syndrome and high C-reactive protein serum levels with incident major neurocognitive disorder: Results from the Quebec NuAge cohort J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2025-02-05 Olivier Beauchet, Kevin Galéry, Pierrette Gaudreau, Gilles Allali
Both motoric cognitive risk syndrome (MCR) and C-reactive protein (CRP) serum levels have been separately associated with increased risk of incident major neurocognitive disorder. The study aims to compare the CRP serum levels of older adults with and without MCR, and to examine the associations of MCR, CRP serum levels and their combination with incident major neurocognitive disorder. 915 individuals
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Tailored Approach to Designing a Digital Research Platform for Adults Aged 95 and older: SuperAgers Family Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2025-02-05 Sofiya Milman, Aisha Montgomery, Nir Barzilai, Tina Gao, Kara A Wilson, Thomas Perls, Aoife Mc Govern Leahy, Elizabeth Burgis, Megan Ruxton, Praduman Jain, Alan R Shuldiner
Background The SuperAgers Family study aims to investigate phenotypic and genetic mechanisms related to healthy aging in nonagenarians, centenarians, and their family members. A remote study design was tested to demonstrate the feasibility of using digital technology to conduct health research within this rare population of advanced age. This paper describes key design elements of the digital research
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Soluble Aβ pathology predicts neurodegeneration and cognitive decline independently on p-tau in the earliest Alzheimer's continuum: Evidence across two independent cohorts Alzheimers Dement. (IF 13.0) Pub Date : 2025-02-03 Raffaele Cacciaglia, Carles Falcón, Gonzalo Sánchez Benavides, Anna Brugulat-Serrat, Marta Milà Alomà, Marc Suárez Calvet, José Luis Molinuevo, Karine Fauria, Carolina Minguillón, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Kaj Blennow, Henrik Zetterberg, Luigi Lorenzini, Alle Meije Wink, Silvia Ingala, Frederik Barkhof, Craig W. Ritchie, Juan Domingo Gispert
Identifying the link between early Alzheimer's disease (AD) pathological changes and neurodegeneration in asymptomatic individuals may lead to the discovery of preventive strategies. We assessed longitudinal brain atrophy and cognitive decline as a function of cerebrospinal fluid (CSF) AD biomarkers in two independent cohorts of cognitively unimpaired (CU) individuals.
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Inhibition of soluble epoxide hydrolase ameliorates cerebral blood flow autoregulation and cognition in alzheimer's disease and diabetes-related dementia rat models Geroscience (IF 5.3) Pub Date : 2025-02-04 Chengyun Tang, Jane J. Border, Huawei Zhang, Andrew Gregory, Shan Bai, Xing Fang, Yedan Liu, Shaoxun Wang, Sung Hee Hwang, Wenjun Gao, Gilbert C. Morgan, Jhania Smith, David Bunn, Cameron Cantwell, Karen M. Wagner, Christophe Morisseau, Jun Yang, Seung Min Shin, Philip O’Herron, Zsolt Bagi, Jessica A. Filosa, Yanbin Dong, Hongwei Yu, Bruce D. Hammock, Richard J. Roman, Fan Fan
Alzheimer's Disease and Alzheimer's Disease-related dementias (AD/ADRD) pose major global healthcare challenges, with diabetes mellitus (DM) being a key risk factor. Both AD and DM-related ADRD are characterized by reduced cerebral blood flow, although the exact mechanisms remain unclear. We previously identified compromised cerebral hemodynamics as early signs in TgF344-AD and type 2 DM-ADRD (T2DN)
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VisionMD: an open-source tool for video-based analysis of motor function in movement disorders npj Parkinsons Dis. (IF 6.7) Pub Date : 2025-02-04 Gabriela Acevedo, Florian Lange, Carolina Calonge, Robert Peach, Joshua K. Wong, Diego L. Guarin
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Deprescribing in cognitively vulnerable older people: development and validation of STOPPCog criteria Age Ageing (IF 6.0) Pub Date : 2025-02-04 Siobhan McGettigan, Denis Curtin, Denis O’Mahony
Objective To validate STOPPCog, a list of explicit criteria for potentially inappropriate medication use in cognitively vulnerable older adults. Design A Delphi consensus survey of an expert panel comprising academic geriatricians, old age psychiatrists, general practitioners, and clinical pharmacists. Setting Ireland. Subjects Nine panellists. Methods STOPPCog criteria were initially created by the
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Utilisation of nursing home care before and after the 2015 Dutch national reform: an interrupted time series analysis Age Ageing (IF 6.0) Pub Date : 2025-02-04 Janet L MacNeil Vroomen, Joost D Wammes, Bram Wouterse, Martin Smalbrugge, Terrence E Murphy
Background The Netherlands introduced abrupt, large-scale, long-term care (LTC) reforms in 2015 that promoted ageing-in-place. However, there has been no comprehensive population-level study evaluating how these reforms have impacted nursing home (NH) utilisation. This study examines the association between the 2015 reforms with national monthly rates of NH admissions and survival time amongst newly
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Engagement of Older Adults in the Design, Implementation and Evaluation of Artificial Intelligence Systems for Aging: A Scoping Review J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2025-02-04 Hannah Cho, Oonjee Oh, Nancy Greene, Larissa Gordon, Sherry Morgan, Lisa Walke, George Demiris
Integration of artificial intelligence (AI) in health and healthcare, especially for older adults, has significantly advanced healthcare delivery. AI technologies, with capabilities such as self-learning and pattern recognition, are employed to address social isolation and monitor older adults' daily activities. However, rapid AI development often fails to consider the heterogeneous needs of older
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Intrinsic brain functional connectivity mediates the relationship between psychological resilience and cognitive decline in ageing Geroscience (IF 5.3) Pub Date : 2025-02-03 Menglu Chen, Mengxia Gao, Junji Ma, Tatia M. C. Lee
Ageing individuals often experience cognitive decline and intrinsic functional connectivity (FC) changes. Psychological resilience, a personality trait that reflects the capacity to adapt and cope with age-related challenges, plays a key role in mitigating cognitive decline. In this study involving 101 older adults, we investigated how psychological resilience influences cognitive decline measured
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Effects of home-based exercise with or without cognitive training on cognition and mobility in cardiac patients: A randomized clinical trial Geroscience (IF 5.3) Pub Date : 2025-02-03 Florent Besnier, Emma Gabrielle Dupuy, Christine Gagnon, Thomas Vincent, Tudor Vrinceanu, Caroll-Ann Blanchette, Josep Iglesies-Grau, Kathia Saillant, Malorie Chabot-Blanchet, Sylvie Belleville, Martin Juneau, Paolo Vitali, Mathieu Gayda, Anil Nigam, Louis Bherer
This randomized controlled trial compared the effects of home-based exercise, with or without cognitive training, on cognition and physical function in individuals aged 50 years and older with stable CVD during the COVID-19 pandemic. 122 patients (67.3 ± 7.9 years, 71% men) with stable CVD (77% coronary heart disease) were randomly assigned (1:1) to (1) Home-based physical exercise alone, or (2) Home-based
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Evaluation of claims-based frailty measurements in older patients with cancer: a retrospective cohort study Age Ageing (IF 6.0) Pub Date : 2025-02-03 Hirooka Kayo, Kanno Yusuke, Itoh Sakiko, Sagawa Mieko, Sakano Tomomi, Takahashi Kunihiko, Anzai Tatsuhiko, Fukui Sakiko
Background Frailty is associated with poor outcomes in older adults with cancer. Several efforts have been made to assess frailty using the administrative claims data based on the number of clinical diagnosis codes, yet the literature reporting on this is scarce. This study aimed to evaluate the impact of frailty measures using administrative databases in Japan. Design A retrospective cohort study
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Creating dementia-friendly travel: enhancing accessibility and inclusion Age Ageing (IF 6.0) Pub Date : 2025-02-03 Sara Solis-Lopez, Dafne Estefania Durón-Reyes, Raquel Gutiérrez-Zuñiga, Joaquin Migeot, Brian Lawlor, Roman Romero-Ortuno
The growing participation of older adults in travel is reshaping this industry and highlighting the need for inclusive travel experiences, particularly for people living with dementia (PLwD). While travel provides substantial physical, psychological, cognitive and social benefits that promote active and healthy ageing, it also presents significant challenges. Although physical disabilities are generally
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Impact of in-hospital medication changes on clinical outcomes in older inpatients: the journey and destination Age Ageing (IF 6.0) Pub Date : 2025-02-03 Nashwa Masnoon, Sarita Lo, Danijela Gnjidic, Andrew J McLachlan, Fiona M Blyth, Rosemary Burke, Ana W Capuano, Sarah N Hilmer
Background Medication review is integral in the pharmacological management of older inpatients. Objective To assess the association of in-hospital medication changes with 28-day postdischarge clinical outcomes. Methods Retrospective cohort of 2000 inpatients aged ≥75 years. Medication changes included the number of increases (medications started or dose-increased) and decreases (medications stopped
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Correction to: Frailty in colorectal cancer-are we speaking the same language? Age Ageing (IF 6.0) Pub Date : 2025-02-02
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Supporting older people with cognitive impairment during and after hospital stays with intersectoral care management (intersec-CM)-results of a randomised clinical trial. Age Ageing (IF 6.0) Pub Date : 2025-02-02 Melanie Boekholt,Angela Nikelski,Fanny Schumacher-Schoenert,Friederike Kracht,Horst Christian Vollmar,Wolfgang Hoffmann,Stefan Henner Kreisel,Jochen René Thyrian
BACKGROUND The transition from hospital to primary care is a risk factor for negative health outcomes in people with cognitive impairment. OBJECTIVE To test the effectiveness of intersectoral care management during the transition from hospital to primary care on repeated admission to hospital, functionality and institutionalisation in people with cognitive impairment. DESIGN Longitudinal multisite
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The prognostic and neuroendocrine implications of SLC25A29-mediated biomass signature in prostate cancer Geroscience (IF 5.3) Pub Date : 2025-01-31 Chia-Chang Wu, Su-Wei Hu, Shao-Wei Dong, Kai-Yi Tzou, Chien Hsiu Li
Dysregulated solutes are linked to cancer progression, with associated carriers being potential targets for prognosis and treatment. Androgen deprivation therapy (ADT) is essential for prostate cancer (PCa) progression, but secondary resistance often leads to androgen-independent tumor growth, necessitating new prognostic biomarkers. Transcriptome-based datasets identify SLC25A29, an arginine carrier
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The unity/diversity framework of executive functions: behavioral and neural evidence in older adults Geroscience (IF 5.3) Pub Date : 2025-01-31 Sheng-Ju Guo, Ping Wang, Li-Zhi Cao, Hui-Jie Li
Executive functions (EFs), encompassing inhibition, shifting, and updating as three fundamental subdomains, are typically characterized by a unity/diversity construct. However, given the dedifferentiation trend observed in aging, it remains controversial whether the construct of EFs in older adults becomes unidimensional or maintains unity/diversity. This study aims to explore and validate the construct
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Comparative phenotyping of C57BL/6J substrains reveals distinctive patterns of cardiac aging Geroscience (IF 5.3) Pub Date : 2025-01-30 Sophia Walter, Patricia Baumgarten, Niklas Hegemann, Steffen P. Häseli, Stefanie Deubel, Julia Jelleschitz, Annika Höhn, Nikolaus Berndt, Wolfgang M. Kuebler, Jana Grune, Christiane Ott
Research in aging often refers to animal models, particularly C57BL/6J (B6J) mice, considered gold standard. However, B6J mice are distributed by different suppliers, which results in divers substrains exhibiting notable phenotypic differences. To ensure a suitable phenotype of cardiac aging, we performed heart analyses of young (5 months) and old B6J mice (24 months) from two substrains: B6JRj (Janvier)
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Role for neurological and immunological resilience in the pathway of the aging muscle powerpenia: InCHIANTI study longitudinal results Geroscience (IF 5.3) Pub Date : 2025-01-30 Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Matteo Candeloro, Stefano Volpato, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Toshiko Tanaka, Luigi Ferrucci
The neuromuscular junction shows several degenerative changes with aging, resulting in a reduction of transmission efficacy. These changes, paired with low-grade chronic inflammation, were considered triggers of the aging muscle processes. The main objective of this study is to assess the role of leukocyte count–derived ratios, nerve conduction velocity (NCV), and compound muscle action potential (CMAP)
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An mTOR inhibitor discovery system using drug-sensitized yeast Geroscience (IF 5.3) Pub Date : 2025-01-30 Anna K. Breen, Sarah Thomas, David Beckett, Matthew Agsalud, Graham Gingras, Judd Williams, Brian M. Wasko
Inhibition of the target of rapamycin (TOR/mTOR) protein kinase by the drug rapamycin extends lifespan and health span across diverse species. However, rapamycin has potential off-target and side effects that warrant the discovery of additional TOR inhibitors. TOR was initially discovered in Saccharomyces cerevisiae (yeast) which contains two TOR paralogs, TOR1 and TOR2. Yeast lacking functional Tor1
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Better objective sleep quality is associated with higher gut microbiota richness in older adults Geroscience (IF 5.3) Pub Date : 2025-01-31 Maria Teresa Wijaya, Ji-Tseng Fang, Geng-Hao Liu, Yuan-Ming Yeh, Ning-Hung Chen, Chih-Ming Lin, Kuain-Yi Wu, Chih-Mao Huang, Shwu-Hua Lee, Tatia M. C. Lee
Aging is associated with disrupted sleep patterns, such as fragmented sleep and reduced efficiency, leading to negative health outcomes. There is evidence of a bidirectional relationship between sleep and gut microbiota, which plays a key role in the gut-brain axis and overall health. However, studies on this relationship in older adults have limited generalizability and show conflicting results, highlighting
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Combining non-invasive brain stimulation techniques and EEG markers analysis: an innovative approach to cognitive health in aging Geroscience (IF 5.3) Pub Date : 2025-01-31 Chiara Pappalettera, Anna Fabbrocino, Francesca Miraglia, Paolo Maria Rossini, Fabrizio Vecchio
In an era marked by a rapidly aging global population, delving into the intricate neurophysiological changes that accompany the aging process assumes paramount importance. This narrative review offers a comprehensive exploration of the intricate relationship between electromagnetic neuromodulation and electroencephalography (EEG) within the context of aging. Moreover, it showed the promising landscape
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Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts Geroscience (IF 5.3) Pub Date : 2025-01-31 Luyao Wang, Wenjing Hu, Fan Dong, Can Sheng, Jinglong Wu, Ying Han, Jiehui Jiang, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowski, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marcus Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David
Brain network dynamics have been extensively explored in patients with subjective cognitive decline (SCD). However, these studies are susceptible to individual differences, scanning parameters, and other confounding factors. Therefore, how to reveal subtle SCD-related subtle changes remains unclear. Cross-sectional and longitudinal resting-state functional magnetic resonance imaging data from both
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Nocturia as a clinical marker of loss of function and resilience or risk factor for frailty in older adults? Results of the Berlin Aging Study II Geroscience (IF 5.3) Pub Date : 2025-01-31 Maximilian König, Carolin Malsch, Joany Mariño, Valentin Max Vetter, Yulia Komleva, Ilja Demuth, Elisabeth Steinhagen-Thiessen
The current study examined cross-sectional and longitudinal associations between nocturia and frailty in a cohort of men and women aged 60 years and older, as evidence on this topic was lacking. We analyzed baseline and follow-up data (n = 1671) from the Berlin Aging Study II (BASE-II), a prospective longitudinal cohort study focusing on the factors associated with “healthy” vs. “unhealthy” aging.
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Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila Geroscience (IF 5.3) Pub Date : 2025-01-31 Olivia L. Mosley, Joel A. Villa, Advaitha Kamalakkannan, Eliyashaib James, Jessica M. Hoffman, Yang Lyu
Dietary restriction (DR) is widely considered to be one of the most potent approaches to extend healthy lifespan across various species, yet it has become increasingly apparent that DR-mediated longevity is influenced by biological and non-biological factors. We propose that current priorities in the field should include understanding the relative contributions of these factors to elucidate the mechanisms
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Investigating the role of adipose tissue in mobility and aging: design and methods of the Adipose Tissue ancillary to the Study of Muscle, Mobility and Aging (SOMMA-AT) J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2025-01-31 Reichelle X Yeo, Theresa Mau, Zana M Ross, Nicholas P Edenhoffer, Jingfang Liu, Haley N Barnes, Li-Yung Lui, Joshua N Adkins, James A Sanford, Marcus M Seldin, Carlos H Viesi, Mingqi Zhou, Heather L Gregory, Frederico G S Toledo, Maja Stefanovic-Racic, Mary Lyles, Ashlee N Wood, Polly E Mattila, Elizabeth A Blakley, Iva Miljkovic, Peggy M Cawthon, Anne B Newman, Stephen B Kritchevsky, Steven R Cummings
Background Age-related changes in adipose tissue impact chronic medical diseases and mobility disability but mechanism remains poorly understood. The goal of this study is to define methods for phenotyping unique characteristics of adipose tissue from older adults. Methods Older adults enrolled in Study of Muscle, Mobility and Aging selected for the adipose tissue ancillary (SOMMA-AT; N=210, 52.38%