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Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America npj Parkinsons Dis. (IF 9.304) Pub Date : 2022-08-08 Bruno Lopes Santos-Lobato, Artur F. Schumacher-Schuh, Ignacio F. Mata
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Using Alzheimer's disease blood tests to accelerate clinical trial enrollment Alzheimers Dement. (IF 16.655) Pub Date : 2022-08-07 Suzanne E. Schindler, Yan Li, Melody Li, Alyssa Despotis, Ethan Park, Liberty Vittert, Barton H. Hamilton, Kyle B. Womack, Benjamin Saef, David M. Holtzman, John C. Morris, Randall J. Bateman, Mahendra R. Gupta
Screening potential participants in Alzheimer's disease (AD) clinical trials with amyloid positron emission tomography (PET) is often time consuming and expensive.
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Testing the link between isoaspartate and Alzheimer's disease etiology Alzheimers Dement. (IF 16.655) Pub Date : 2022-08-04 Jijing Wang, Cong Guo, Zhaowei Meng, Marissa D. Zwan, Xin Chen, Sven Seelow, Susanna L. Lundström, Sergey Rodin, Charlotte E. Teunissen, Roman A. Zubarev
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Cumulative loneliness and subsequent memory function and rate of decline among adults aged ≥50 in the United States, 1996 to 2016 Alzheimers Dement. (IF 16.655) Pub Date : 2022-08-03 Xuexin Yu, Ashly C. Westrick, Lindsay C. Kobayashi
The study objective was to investigate the association between loneliness duration and memory function over a 20-year period.
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Cognitive resilience depends on white matter connectivity: The Maastricht Study Alzheimers Dement. (IF 16.655) Pub Date : 2022-08-03 Nathan R. DeJong, Jacobus F.A. Jansen, Martin P.J. van Boxtel, Miranda T. Schram, Coen D.A. Stehouwer, Pieter C. Dagnelie, Carla J.H. van der Kallen, Abraham A. Kroon, Anke Wesselius, Annemarie Koster, Walter H. Backes, Sebastian Köhler
Differences in brain network connectivity may reflect the capability of the neurological substrate to compensate for brain damage and preserve cognitive function (cognitive reserve). We examined the associations between white matter connectivity, brain damage markers, and cognition in a population sample of middle-aged individuals.
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Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain Alzheimers Dement. (IF 16.655) Pub Date : 2022-08-03 Christina M. Moloney, Sydney A. Labuzan, Julia E. Crook, Habeeba Siddiqui, Monica Castanedes-Casey, Christian Lachner, Ronald C. Petersen, Ranjan Duara, Neill R. Graff-Radford, Dennis W. Dickson, Michelle M. Mielke, Melissa E. Murray
Alzheimer's disease (AD) biomarkers are increasingly more reliable in predicting neuropathology. To facilitate interpretation of phosphorylated tau sites as an early fluid biomarker, we sought to characterize which neurofibrillary tangle maturity levels (pretangle, intermediary 1, mature tangle, intermediary 2, and ghost tangle) are recognized.
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Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain Geroscience (IF 7.581) Pub Date : 2022-08-05 Christina Dimovasili, Ashley E. Fair, Isabella R. Garza, Katelyn V. Batterman, Farzad Mortazavi, Tara L. Moore, Douglas L. Rosene
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Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway npj Parkinsons Dis. (IF 9.304) Pub Date : 2022-08-06 Jie Xu, Yun-Lin Ao, Chunhui Huang, Xiubao Song, Guiliang Zhang, Wei Cui, Yuqiang Wang, Xiao-Qi Zhang, Zaijun Zhang
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Elevation of gangliosides in four brain regions from Parkinson’s disease patients with a GBA mutation npj Parkinsons Dis. (IF 9.304) Pub Date : 2022-08-06 Shani Blumenreich, Tamar Nehushtan, Or B. Barav, Jennifer T. Saville, Tamir Dingjan, John Hardy, Maria Fuller, Anthony H. Futerman
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New horizons in life extension, healthspan extension and exceptional longevity Age Ageing (IF 12.782) Pub Date : 2022-08-06 David G Le Couteur, Nir Barzilai
Many common chronic diseases and syndromes are ageing-related. This raises the prospect that therapeutic agents that target the biological changes of ageing will prevent or delay multiple diseases with a single therapy. Gerotherapeutic drugs are those that target pathways involved in ageing, with the aims of reducing the burden of ageing-related diseases and increasing lifespan and healthspan. The
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Annual risk of falls resulting in emergency department and hospital attendances for older people: an observational study of 781,081 individuals living in Wales (United Kingdom) including deprivation, frailty and dementia diagnoses between 2010 and 2020 Age Ageing (IF 12.782) Pub Date : 2022-08-06 Robyn Hollinghurst, Neil Williams, Rebecca Pedrick-Case, Laura North, Sara Long, Richard Fry, Joe Hollinghurst
Background falls are common in older people, but associations between falls, dementia and frailty are relatively unknown. The impact of the COVID-19 pandemic on falls admissions has not been studied. Aim to investigate the impact of dementia, frailty, deprivation, previous falls and the differences between years for falls resulting in an emergency department (ED) or hospital admission. Study Design
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Specific gut microbiota alterations in essential tremor and its difference from Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2022-08-05 Pingchen Zhang, Pei Huang, Juanjuan Du, Yixi He, Jin Liu, Guiying He, Shishuang Cui, Weishan Zhang, Gen Li, Shengdi Chen
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Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2022-08-05 Toshiki Tezuka, Daisuke Taniguchi, Mariko Sano, Tomoyo Shimada, Yutaka Oji, Taiji Tsunemi, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, Jun Ogata, Kahori Shiba-Fukushima, Manabu Funayama, Kenya Nishioka, Yuzuru Imai, Nobutaka Hattori
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Effectiveness of exergaming-based interventions for mobility and balance performance in older adults with Parkinson’s disease: systematic review and meta-analysis of randomised controlled trials Age Ageing (IF 12.782) Pub Date : 2022-08-05 Jiaxin Zhang, Yan Luximon, Marco Y C Pang, Hailiang Wang
Background exergaming-based interventions (EbIs) have been proposed to improve older adults’ mobility and balance performance. However, the effectiveness of such interventions for older adults with Parkinson’s disease (OAPD) remains unclear. Methods seven databases (Web of Science, Medline, Academic Search Premier, CINAHL Complete, PsycINFO, PsychARTICLE and PubMed) were searched up to 7 April 2022
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Predictors of returning home after hip fracture: a prospective cohort study using the UK National Hip Fracture Database (NHFD) Age Ageing (IF 12.782) Pub Date : 2022-08-05 Samuel Hawley, Dominic Inman, Celia L Gregson, Michael Whitehouse, Antony Johansen, Andrew Judge
Introduction our objective was to describe trends in returning home after hospitalisation for hip fracture and identify predictive factors of this important patient-focussed outcome. Methods a cohort of hip fracture patients from England and Wales (2018–2019) resident in their own home pre-admission were analysed to identify patient and service factors associated with returning home after hospital
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Trauma care in older people: charting a path from outlier to excellence Age Ageing (IF 12.782) Pub Date : 2022-08-05 Gulraj S Matharu, Michael R Whitehouse, Karen Harding, Michael Kelly, Katherine Walsh
Trauma in older people leads to substantial morbidity and mortality. The National Hip Fracture Database (NHFD) has driven improved practice with units compared to identify outliers. In 2013, our unit was an outlier for mortality post hip fracture (30-day mortality 12.2% vs. 8.3% nationally). This triggered external review. In 2019 the unit was highlighted as an exemplar in the UK. We describe the process
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Development and validation of a frailty index compatible with three interRAI assessment instruments Age Ageing (IF 12.782) Pub Date : 2022-08-05 Rebecca Abey-Nesbit, Ulrich Bergler, John W Pickering, Prasad S Nishtala, Hamish Jamieson
Background a Frailty Index (FI) calculated by the accumulation of deficits is often used to quantify the extent of frailty in individuals in specific settings. This study aimed to derive a FI that can be applied across three standardised international Residential Assessment Instrument assessments (interRAI), used at different stages of ageing and the corresponding increase in support needs. Methods
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New horizons in the ageing autonomic nervous system: orthostatic hypotension and supine hypertension Age Ageing (IF 12.782) Pub Date : 2022-08-05 Melanie Dani, Patricia Taraborrelli, Dimitrios Panagopoulos, Andreas Dirksen, Miriam Torocastro, Richard Sutton, Phang Boon Lim
Blood pressure regulation is an automatic, moment-by-moment buffering of the blood pressure in response to physiological changes such as orthostasis, exercise and haemorrhage. This finely orchestrated reflex is called the baroreflex. It is a regulated arc of afferent, central and efferent arms. Multiple physiological changes occur with ageing that can disrupt this reflex, making blood pressure regulation
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Examining the prevalence and correlates of multimorbidity among community-dwelling older adults: cross-sectional evidence from the Canadian Longitudinal Study on Aging (CLSA) first-follow-up data Age Ageing (IF 12.782) Pub Date : 2022-08-05 James H B Im, Rebecca Rodrigues, Kelly K Anderson, Piotr Wilk, Saverio Stranges, Kathryn Nicholson
Introduction multimorbidity has become an increasingly important issue for many populations around the world, including Canada. The objectives of this study were to estimate the prevalence of multimorbidity at first follow-up and to identify factors associated with multimorbidity using data from the Canadian Longitudinal Study on Aging (CLSA). Methods this study included 27,701 community-dwelling participants
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Shared decision-making for the treatment of proximal femoral fractures in frail institutionalised older patients: healthcare providers’ perceived barriers and facilitators Age Ageing (IF 12.782) Pub Date : 2022-08-05 Inge Spronk, Sverre A I Loggers, Pieter Joosse, Hanna C Willems, Romke Van Balen, Taco Gosens, Kornelis J Ponsen, Jeroen Steens, L C P (Marc) Van de Ree, Rutger G Zuurmond, Michael H J Verhofstad, Esther M M Van Lieshout, Suzanne Polinder
Introduction Proximal femoral fractures are common in frail institutionalised older patients. No convincing evidence exists regarding the optimal treatment strategy for those with a limited pre-fracture life expectancy, underpinning the importance of shared decision-making (SDM). This study investigated healthcare providers’ barriers to and facilitators of the implementation of SDM. Methods Dutch healthcare
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Association of multimorbidity patterns with incident disability and recovery of independence among middle-aged and older adults Age Ageing (IF 12.782) Pub Date : 2022-08-05 Jiayi Zhou, Melissa Y Wei, Jingyi Zhang, Hua Liu, Chenkai Wu
Objective to identify multimorbidity patterns among middle-aged and older adults in China and examine how these patterns are associated with incident disability and recovery of independence. Methods data were from The China Health and Retirement Longitudinal Study. We included 14,613 persons aged ≥45 years. Latent class analysis (LCA) was conducted to identify multimorbidity patterns with clinical
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Associations of bioavailable serum testosterone with cognitive function in older men: results from the National Health and Nutrition Examination Survey J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-05 Panagiotis Giannos, Konstantinos Prokopidis, David D Church, Ben Kirk, Paul T Morgan, Mary Ni Lochlainn, Helen Macpherson, David R Woods, Theocharis Ispoglou
Background Age-associated cognitive decline may be influenced by testosterone status. However, studies evaluating the impact of bioavailable testosterone, the active, free testosterone, on cognitive function are scarce. Our study determined the relationship between calculated bioavailable testosterone and cognitive performance in older men. Methods We used data from the US National Health and Nutrition
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Inflammation and epigenetic ageing are largely independent markers of biological ageing and mortality J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-04 Lachlan Cribb, Allison M Hodge, Chenglong Yu, Sherly X Li, Dallas R English, Enes Makalic, Melissa C Southey, Roger L Milne, Graham G Giles, Pierre-Antoine Dugué
Limited evidence exists on the link between inflammation and epigenetic ageing. We aimed to 1) assess the cross-sectional and prospective associations of 22 inflammation-related plasma markers and a signature of inflammaging with epigenetic ageing; 2) determine whether epigenetic ageing and inflammaging are independently associated with mortality. Blood samples from 940 participants in the Melbourne
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Using conditional inference forests to examine predictive ability for future falls and syncope in older adults: Results from The Irish Longitudinal Study on Ageing J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-03 Orna A Donoghue, Belinda Hernandez, Matthew D L O’Connell, Rose Anne Kenny
Background The extent to which gait and mobility measures predict falls relative to other risk factors is unclear. This study examined predictive accuracy of over 70 baseline risk factors, including gait and mobility, for future falls and syncope using conditional inference forest models. Methods Data from three waves of The Irish Longitudinal Study on Ageing (TILDA), a population-based study of community-dwelling
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Association between late-life weight change and dementia: A population-based cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-03 Jie Guo, Anna Marseglia, Ying Shang, Abigail Dove, Giulia Grande, Laura Fratiglioni, Weili Xu
Background The impact of late-life weight changes on incident dementia is unclear. We aimed to investigate the associations of body mass index (BMI) and weight changes with dementia and to explore the role of APOE ɛ4 in these associations. Methods A total of 1,673 dementia-free participants aged ≥60 years were followed for an initial 6 years to detect changes in BMI/weight and then for an additional
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Development of a Novel Multi-dimensional Measure of Aging to Predict Mortality and Morbidity in the Prospective MJ Cohort J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-03 Sicong Wang, Chi Pang Wen, Wenyuan Li, Shu Li, Mingxi Sun, Andi Xu, Min Kuang Tsai, David Ta-Wei Chu, Shan Pou Tsai, Huakang Tu, Xifeng Wu
Background Although biological aging has been proposed as a more accurate measure of aging, few biological aging measures have been developed for Asians, especially for young adults. Methods A total of 521,656 participants were enrolled in the MJ cohort (1996 -2011) and were followed until death, loss-to-follow-up, or Dec 31, 2011, whichever came first. We selected 14 clinical biomarkers including
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The effects of repetitive transcranial magnetic stimulation on standing balance and walking in older adults with age-related neurological disorders: a systematic review and meta-analysis J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-03 Jun Zhou, Yan Chen, Trenton Gin, Dapeng Bao, Junhong Zhou
Background Considerable evidence showed that repetitive transcranial magnetic stimulation (rTMS) can improve standing balance and walking performance in older adults with age-related neurological disorders. We here thus completed a systematic review and meta-analysis to quantitatively examine such benefits of rTMS. Methods A search strategy based on the PICOS principle was used to obtain the literature
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Clinical trajectories and biomarkers for weight variability in early Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2022-08-02 Daniele Urso, Daniel J. van Wamelen, Lucia Batzu, Valentina Leta, Juliet Staunton, José A. Pineda-Pardo, Giancarlo Logroscino, Jagdish Sharma, K. Ray Chaudhuri
Unexplained weight changes that occur in Parkinson’s disease (PD), are often neglected and remain a poorly understood non-motor feature in patients with PD. A specific ‘Park-weight’ phenotype with low body weight has been described, and our aim was to evaluate the clinical and prognostic trajectories and biomarkers of weight variability in PD. We evaluated body weight-related biomarkers in 405 de novo
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A summary index derived from Kinect to evaluate postural abnormalities severity in Parkinson’s Disease patients npj Parkinsons Dis. (IF 9.304) Pub Date : 2022-08-02 Ronghua Hong, Tianyu Zhang, Zhuoyu Zhang, Zhuang Wu, Ao Lin, Xiaoyun Su, Yue Jin, Yichen Gao, Kangwen Peng, Lixi Li, Lizhen Pan, Hongping Zhi, Qiang Guan, Lingjing Jin
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Putting participants and study partners FIRST when clinical trials end early Alzheimers Dement. (IF 16.655) Pub Date : 2022-08-02 Emily A. Largent, Sarah Walter, Nancy Childs, Penny A. Dacks, Shana Dodge, Hana Florian, Jonathan Jackson, Jorge J. Llibre Guerra, Erin Iturriaga, David S. Miller, Monica Moreno, Rachel L. Nosheny, Thomas O. Obisesan, Elena Portacolone, Bernadette Siddiqi, Nina Silverberg, Rueben C. Warren, Kathleen A. Welsh-Bohmer, Rebecca M. Edelmayer
Between 2018 and 2019, multiple clinical trials ended earlier than planned, resulting in calls to improve communication with and support for participants and their study partners (“dyads”). The multidisciplinary Participant Follow-Up Improvement in Research Studies and Trials (Participant FIRST) Work Group met throughout 2021. Its goals were to identify best practices for communicating with and supporting
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Hippocampal DNA Methylation, Epigenetic Age and Spatial Memory Performance in Young And Old Rats J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-02 Priscila Chiavellini, Marianne Lehmann, Martina Canatelli Mallat, Joseph A Zoller, Claudia B Herenu, Gustavo R Morel, Steve Horvath, Rodolfo G Goya
In humans and rats, aging is associated with a progressive deterioration of spatial learning and memory. These functional alterations are correlated with morphological and molecular changes in the hippocampus. Here, we assessed age-related changes in DNA methylation (DNAm) landscape in the rat hippocampus and the correlation of spatial memory with hippocampal DNAm age in 2.6 months and 26.6 months
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Bacterial DNAemia in older subjects and nonagenarian offspring and association with redox biomarkers: results from MARK-AGE Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-02 Robertina Giacconi, Patrizia D’Aquila, Marco Malavolta, Francesco Piacenza, Alexander Bürkle, María Moreno Villanueva, Martijn E T Dollé, Eugène Jansen, Tilman Grune, Efstathios S Gonos, Claudio Franceschi, Miriam Capri, Daniela Gradinaru, Beatrix Grubeck-Loebenstein, Ewa Sikora, Wolfgang Stuetz, Daniela Weber, Olivier Toussaint, Florence Debacq-Chainiaux, Antti Hervonen, Mikko Hurme, P Eline Slagboom
Aging and age-related diseases have been linked to microbial dysbiosis with changes in blood bacterial DNA concentration. This condition may promote chronic low-grade inflammation, which can be further aggravated by antioxidant nutrient deficiency. Low plasma carotenoids are associated with an increased risk of inflammation and cellular damage and predict mortality. However, no evidence is yet available
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MyMD-1 improves health span and prolongs lifespan in old mice: A non-inferiority study to rapamycin J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-08-02 Elena Sabini, Alison O’Mahony, Patrizio Caturegli
Aging and age-related diseases represent a compelling therapeutic goal for senolytics and drugs targeting inflammatory or metabolic pathways. We compared MyMD-1, a synthetic derivative of the alkaloid myosmine capable of suppressing TNF-α production, to rapamycin, the best characterized drug endowed with anti-aging properties. In vivo, a longitudinal cohort of 54 C57BL/6 mice, 19-month-old at the start
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The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease Alzheimers Dement. (IF 16.655) Pub Date : 2022-07-31 Oskar Hansson, Rebecca M. Edelmayer, Adam L. Boxer, Maria C. Carrillo, Michelle M. Mielke, Gil D. Rabinovici, Stephen Salloway, Reisa Sperling, Henrik Zetterberg, Charlotte E. Teunissen
Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD pathological
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Coenzyme Q10 levels associated to cognitive functioning and executive function in older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-07-31 Cristina Fernández-Portero, Josué G Amián, Rocío de la Bella, Guillermo López-Lluch, David Alarcón
Brain deterioration with age is associated with inflammation and oxidative stress that result in structural and functional changes. Recent studies have indicated that coenzyme Q10 (CoQ10) is associated to neurological oxidative stress and cognitive impairment. Studies with older people have shown a relationship between neurodegenerative diseases and CoQ10 levels. However, no studies have analyzed the
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European Working Group on Sarcopenia in Older People 2010 (EWGSOP1) and 2019 (EWGSOP2) criteria or slowness: which is the best predictor of mortality risk in older adults? Age Ageing (IF 12.782) Pub Date : 2022-07-30 Maria Claudia Bernardes Spexoto, Paula Camila Ramírez, Roberta de Oliveira Máximo, Andrew Steptoe, Cesar de Oliveira, Tiago da Silva Alexandre
Objectives to analyse the accuracy of grip strength and gait speed in identifying mortality; to compare the association between mortality and sarcopenia defined by the EWGSOP1 and EWGSOP2 using the best cut-off found in the present study and those recommended in the literature and to test whether slowness is better than these two definitions to identify the risk of death in older adults. Methods a
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Evaluation of the PREDIGT score’s performance in identifying newly diagnosed Parkinson’s patients without motor examination npj Parkinsons Dis. (IF 9.304) Pub Date : 2022-07-29 Juan Li, Tiago A. Mestre, Brit Mollenhauer, Mark Frasier, Julianna J. Tomlinson, Claudia Trenkwalder, Tim Ramsay, Douglas Manuel, Michael G. Schlossmacher
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Rapid olfactory decline during aging predicts dementia and GMV loss in AD brain regions Alzheimers Dement. (IF 16.655) Pub Date : 2022-07-28 Rachel R. Pacyna, S. Duke Han, Kristen E. Wroblewski, Martha K. McClintock, Jayant M. Pinto
Longitudinal multivariable analyses are needed to determine if the rate of olfactory decline during normal cognition predicts subsequent Alzheimer's disease (AD) diagnoses and brain dysmorphology.
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Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer's disease? Alzheimers Dement. (IF 16.655) Pub Date : 2022-07-28 Madia Lozupone, Bruno Pietro Imbimbo, Claudia Balducci, Filomena Lo Vecchio, Paola Bisceglia, Raffaela Rita Latino, Maurizio Leone, Vittorio Dibello, Vincenzo Solfrizzi, Antonio Greco, Antonio Daniele, Mark Watling, Davide Seripa, Francesco Panza
Human apolipoprotein E (apoE) is a 299-amino acid secreted glycoprotein binding cholesterol and phospholipids, and with three common isoforms (APOE ε2, APOE ε3, and APOE ε4). The exact mechanism by which APOE gene variants increase/decrease Alzheimer's disease (AD) risk is not fully understood, but APOE isoforms differently affect brain homeostasis and neuroinflammation, blood–brain barrier (BBB) permeability
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Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan Geroscience (IF 7.581) Pub Date : 2022-07-27 Melanie Spindler, Christiane M. Thiel
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Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions Geroscience (IF 7.581) Pub Date : 2022-07-28 Agata Głuchowska, Dominik Cysewski, Monika Baj-Krzyworzeka, Rafał Szatanek, Kazimierz Węglarczyk, Paulina Podszywałow-Bartnicka, Piotr Sunderland, Ewa Kozłowska, Małgorzata A. Śliwińska, Michał Dąbrowski, Ewa Sikora, Grażyna Mosieniak
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GH deficiency confers protective advantages against Alzheimer’s disease through rescued miRNA expression profile in APP/PS1 mice Geroscience (IF 7.581) Pub Date : 2022-07-28 Sarah Noureddine, Tatiana Saccon, Trina Rudeski-Rohr, Adam Gesing, Jeffrey B. Mason, Augusto Schneider, Joseph Dhabhi, Kendra L. Puig, Sharlene Rakoczy, Holly M. Brown-Borg, Michal M. Masternak
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Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study Geroscience (IF 7.581) Pub Date : 2022-07-26 Manon Pellegrini-Laplagne, Olivier Dupuy, Phillipe Sosner, Laurent Bosquet
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Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study Alzheimers Dement. (IF 16.655) Pub Date : 2022-07-25 Marios K. Georgakis, Rong Fang, Marco Düring, Frank A. Wollenweber, Felix J. Bode, Sebastian Stösser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Düzel, Benno Gesierich, Anna Dewenter, Annika Spottke
It remains unknown whether the global small vessel disease (SVD) burden predicts post-stroke outcomes.
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Increasing Pain Interference is Associated with Cognitive Decline over Four Years among Older Puerto Rican Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-07-26 Sadaf Arefi Milani, Tyler R Bell, Michael Crowe, Caitlin N Pope, Brian Downer
Background Pain is associated with cognitive decline among older adults, but few studies have investigated bidirectional associations between pain and cognitive decline, especially in older Hispanic populations. Our objective is to assess the bidirectional association between pain interference and cognitive performance in a sample of older Puerto Rican adults. Methods Data came from baseline and 4-year
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Neighborhood segregation and cognitive change: Multi-Ethnic Study of Atherosclerosis Alzheimers Dement. (IF 16.655) Pub Date : 2022-07-23 Lilah M. Besser, Oanh L. Meyer, Miranda R. Jones, Duyen Tran, Michaela Booker, Diana Mitsova, Rachel Peterson, James E. Galvin, James R. Bateman, Kathleen M. Hayden, Timothy M. Hughes
We investigated associations between neighborhood racial/ethnic segregation and cognitive change.
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Blood-based bioenergetic profiling reveals differences in mitochondrial function associated with cognitive performance and Alzheimer's disease Alzheimers Dement. (IF 16.655) Pub Date : 2022-07-23 Gargi Mahapatra, Zhengrong Gao, James R. Bateman, Samuel Neal Lockhart, Jaclyn Bergstrom, Amber Renee DeWitt, Jemima Elizabeth Piloso, Philip Adam Kramer, Jenny L. Gonzalez-Armenta, Kimberly Allison Amick, Ramon Casanova, Suzanne Craft, Anthony J. A. Molina
Despite evidence for systemic mitochondrial dysfunction early in Alzheimer's disease (AD) pathogenesis, reliable approaches monitoring these key bioenergetic alterations are lacking. We used peripheral blood mononuclear cells (PBMCs) and platelets as reporters of mitochondrial function in the context of cognitive impairment and AD.
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From Warkworth House to the 21st century care homes: progress marked by persistent challenges Age Ageing (IF 12.782) Pub Date : 2022-07-25 Adam L Gordon, Karen Spilsbury, Wilco P Achterberg, Rich Adams, Liz Jones, Claire Goodman
Long-term care homes play an essential role within health and social care. Successful measures to support older people at home for longer have led to increased prevalence of disability, frailty and cognitive impairment in those who live in care homes over the last two decades. The need for care home places is projected to increase for the next two decades. Modern care homes provide care for people
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Prospective Association Between Plasma Amino Acids And Multimorbidity In Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-07-25 Francisco Félix Caballero, Alberto Lana, Ellen A Struijk, Lucía Arias-Fernández, Humberto Yévenes-Briones, Juan Cárdenas-Valladolid, Miguel Ángel Salinero-Fort, José R Banegas, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia
Background Some amino acids have been associated with aging-related disorders and risk of physical impairment. The aim of this study was to assess the association between plasma concentrations of nine amino acids, including branched-chain and aromatic amino acids, and multimorbidity. Methods This research uses longitudinal data from the Seniors-ENRICA 2 study, a population-based cohort from Spain which
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Myelin and Physical Activity in Older Adults with Cerebral Small Vessel Disease and Mild Cognitive Impairment J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-07-25 Nárlon C Boa Sorte Silva, Elizabeth Dao, Chun Liang Hsu, Roger C Tam, Kevin Lam, Walid Alkeridy, Cornelia Laule, Irene M Vavasour, Ryan G Stein, Teresa Liu-Ambrose
Background Myelin loss is a feature of cerebral small vessel disease (cSVD). Although physical activity levels may exert protective effects over cSVD pathology, its specific relationship with myelin content in people living with the cSVD is unknown. Thus, we investigated whether physical activity levels are associated with myelin in community-dwelling older adults with cSVD and mild cognitive impairment
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High-density surface electromyography as biomarker of muscle aging J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-07-25 Loubna Imrani, Sofiane Boudaoud, Clément Lahaye, Caroline Moreau, Myriam Ghezal, Safa Ben Manaa, Mohamed Doulazmi, Jérémy Laforêt, Frédéric Marin, Kiyoka Kinugawa
Sarcopenia is a muscle disease with adverse changes that increase throughout lifetime, but with different chronological scale between individuals. Addressing “early muscle aging" is becoming a critical issue for prevention. Through the CHRONOS study, we demonstrated the ability of the high-density surface electromyography (HD-sEMG), a non-invasive, wireless, portable technology, to detect both healthy
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Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults Geroscience (IF 7.581) Pub Date : 2022-07-23 Luca Toth, Andras Czigler, Emoke Hegedus, Hedvig Komaromy, Krisztina Amrein, Endre Czeiter, Andriy Yabluchanskiy, Akos Koller, Gergely Orsi, Gabor Perlaki, Attila Schwarcz, Andras Buki, Zoltan Ungvari, Peter J. Toth
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Projections of dependency and associated social care expenditure for the older population in England to 2038: effect of varying disability progression Age Ageing (IF 12.782) Pub Date : 2022-07-24 Andrew Kingston, Raphael Wittenberg, Bo Hu, Carol Jagger
Objectives to assess the effect of recent stalling of life expectancy and various scenarios for disability progression on projections of social care expenditure between 2018 and 2038, and the likelihood of reaching the Ageing Society Grand Challenge mission of five extra healthy, independent years at birth. Design two linked projections models: the Population Ageing and Care Simulation (PACSim) model
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Effects of an art-based intervention in older adults with mild cognitive impairment: a randomised controlled trial Age Ageing (IF 12.782) Pub Date : 2022-07-24 Rong Lin, Yu-ting Luo, Yuan-jiao Yan, Chen-shan Huang, Li-li Chen, Ming-feng Chen, Mo-jun Lin, Hong Li
Background Art-based interventions may delay cognitive decline and improve health-related outcomes in older adults with mild cognitive impairment (MCI). Objective To examine the effects of the Creative Expressive Arts-based Storytelling (CrEAS) program compared to active and waitlist controls on neurocognitive and other health-related outcomes in older people with MCI. Design Three-arm parallel-group
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Association between multimorbidity and hospitalization in older adults: systematic review and meta-analysis Age Ageing (IF 12.782) Pub Date : 2022-07-24 Luciana Pereira Rodrigues, Andréa Toledo de Oliveira Rezende, Felipe Mendes Delpino, Carolina Rodrigues Mendonça, Matias Noll, Bruno Pereira Nunes, Cesar de Oliviera, Erika Aparecida Silveira
Background Multimorbidity is defined as the presence of multiple chronic conditions in the same individual. Multimorbidity is more prevalent in older adults and can lead to several adverse health outcomes. Methods We systematically reviewed evidence from observational studies to verify the association between multimorbidity and hospitalization in older adults. Furthermore, we also aimed to identify
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‘Weighing up risks’: a model of care home staff decision-making about potential resident hospital transfers Age Ageing (IF 12.782) Pub Date : 2022-07-24 Fawn Harrad-Hyde, Natalie Armstrong, Christopher D Williams
Background care home staff play a crucial role in managing residents’ health and responding to deteriorations. When deciding whether to transfer a resident to hospital, a careful consideration of the potential benefits and risks is required. Previous studies have identified factors that influence staff decision-making, yet few have moved beyond description to produce a conceptual model of the decision-making
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Outcomes as experienced by older patients after hospitalisation: satisfaction, acceptance, frustration and hope—a grounded theory study Age Ageing (IF 12.782) Pub Date : 2022-07-24 Maria Johanna van der Kluit, Geke J Dijkstra
Background outcomes of hospitalisation are often described in quantitative terms. It is unknown how older frail patients describe their own outcomes. Objective to discover how older frail persons describe their own hospitalisation outcomes and the meaning of these outcomes for their daily lives. Design Constructivist Grounded Theory approach. Participants frail older people discharged from hospital
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Vitamin D intake and cognitive decline in Blacks and Whites: The role of diet and supplements Alzheimers Dement. (IF 16.655) Pub Date : 2022-07-22 Klodian Dhana, Lisa L. Barnes, Puja Agarwal, Xiaoran Liu, Anisa Dhana, Pankaja Desai, Neelum Aggarwal, Denis A. Evans, Kumar B. Rajan
To determine the role of vitamin D intake on cognitive decline among Blacks and Whites.
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Age-related changes in skeletal muscle iron homeostasis J. Gerontol. A Biol. Sci. Med. Sci. (IF 6.591) Pub Date : 2022-07-23 Francesca M Alves, Scott Ayton, Ashley I Bush, Gordon S Lynch, René Koopman
Sarcopenia is an age-related condition of slow, progressive loss of muscle mass and strength, which contributes to frailty, increased risk of hospitalisation and mortality, and increased health care costs. The incidence of sarcopenia is predicted to increase to >200 million affected older adults worldwide over the next 40 years, highlighting the urgency for understanding biological mechanisms and developing
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Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics Geroscience (IF 7.581) Pub Date : 2022-07-21 Laura Kananen, Mikko Hurme, Alexander Bürkle, Maria Moreno-Villanueva, Jürgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dollé, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm