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Sleep duration and brain MRI measures: Results from the SOL-INCA MRI study Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-29 Kevin A. González, Wassim Tarraf, Ariana M. Stickel, Sonya Kaur, Christian Agudelo, Susan Redline, Linda C. Gallo, Carmen R. Isasi, Jianwen Cai, Martha L. Daviglus, Fernando D. Testai, Charles DeCarli, Hector M. González, Alberto R. Ramos
Sleep duration has been associated with dementia and stroke. Few studies have evaluated sleep pattern–related outcomes of brain disease in diverse Hispanics/Latinos.
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The Alzheimer's Disease Neuroimaging Initiative and the role and contributions of the Private Partners Scientific Board (PPSB) Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-29 Bruce Albala, Eline Appelmans, Ramona Burress, Susan De Santi, Theresa Devins, Gregory Klein, Veronika Logovinsky, Gerald P. Novak, Kim Ribeiro, Mark E. Schmidt, Adam J. Schwarz, David Scott, Sergey Shcherbinin, Eric Siemers, Alessio Travaglia, Christopher J. Weber, Leah White, Julie Wolf-Rodda, Aparna Vasanthakumar
The Alzheimer's Disease Neuroimaging Initiative (ADNI) Private Partners Scientific Board (PPSB) encompasses members from industry, biotechnology, diagnostic, and non-profit organizations that have until recently been managed by the Foundation for the National Institutes of Health (FNIH) and provided financial and scientific support to ADNI programs. In this article, we review some of the major activities
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Visual search in Alzheimer's disease and amnestic mild cognitive impairment: An eye-tracking study Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-29 Hatice Eraslan Boz, Koray Koçoğlu, Müge Akkoyun, Işıl Yağmur Tüfekci, Merve Ekin, Gülden Akdal
Visual search impairment is a potential cognitive marker for Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). The aim of this study is to compare eye movements during visual tracking in AD and aMCI patients versus healthy controls (HCs).
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A multidomain intervention against cognitive decline in an at-risk-population in Germany: Results from the cluster-randomized AgeWell.de trial Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-28 Andrea E. Zülke, Alexander Pabst, Melanie Luppa, Susanne Roehr, Hanna Seidling, Anke Oey, Maria Isabel Cardona, Iris Blotenberg, Alexander Bauer, Solveig Weise, Isabel Zöllinger, Linda Sanftenberg, Christian Brettschneider, Juliane Döhring, Laura Lunden, David Czock, Walter E. Haefeli, Birgitt Wiese, Wolfgang Hoffmann, Thomas Frese, Jochen Gensichen, Hans-Helmut König, Hanna Kaduszkiewicz, Jochen René
We investigated the effectiveness of a multidomain intervention to preserve cognitive function in older adults at risk for dementia in Germany in a cluster-randomized trial.
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CT-based volumetric measures obtained through deep learning: Association with biomarkers of neurodegeneration Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-28 Meera Srikrishna, Nicholas J. Ashton, Alexis Moscoso, Joana B. Pereira, Rolf A. Heckemann, Danielle van Westen, Giovanni Volpe, Joel Simrén, Anna Zettergren, Silke Kern, Lars-Olof Wahlund, Bibek Gyanwali, Saima Hilal, Joyce Chong Ruifen, Henrik Zetterberg, Kaj Blennow, Eric Westman, Christopher Chen, Ingmar Skoog, Michael Schöll
Cranial computed tomography (CT) is an affordable and widely available imaging modality that is used to assess structural abnormalities, but not to quantify neurodegeneration. Previously we developed a deep-learning–based model that produced accurate and robust cranial CT tissue classification.
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Artificial intelligence for neurodegenerative experimental models Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-28 Sarah J. Marzi, Brian M. Schilder, Alexi Nott, Carlo Sala Frigerio, Sandrine Willaime-Morawek, Magda Bucholc, Diane P. Hanger, Charlotte James, Patrick A. Lewis, Ilianna Lourida, Wendy Noble, Francisco Rodriguez-Algarra, Jalil-Ahmad Sharif, Maria Tsalenchuk, Laura M. Winchester, Ümran Yaman, Zhi Yao, , Janice M. Ranson, David J. Llewellyn
Experimental models are essential tools in neurodegenerative disease research. However, the translation of insights and drugs discovered in model systems has proven immensely challenging, marred by high failure rates in human clinical trials.
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Control of hippocampal synaptic plasticity by microglia–dendrite interactions depends on genetic context in mouse models of Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-27 Sarah E. Heuer, Kelly J. Keezer, Amanda A. Hewes, Kristen D. Onos, Kourtney C. Graham, Gareth R. Howell, Erik B. Bloss
Human data suggest susceptibility and resilience to features of Alzheimer's disease (AD) such as microglia activation and synaptic dysfunction are under genetic control. However, causal relationships between these processes, and how genomic diversity modulates them remain systemically underexplored in mouse models.
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Timing and level of educational attainment and late-life cognition in the KHANDLE study Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-26 Yenee Soh, Rachel A. Whitmer, Elizabeth Rose Mayeda, M. Maria Glymour, Chloe W. Eng, Rachel L. Peterson, Kristen M. George, Ruijia Chen, Charles P. Quesenberry, Dan M. Mungas, Charles S. DeCarli, Paola Gilsanz
The timing of educational attainment may modify its effects on late-life cognition, yet most studies evaluate education only at a single time point.
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Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane npj Parkinsons Dis. (IF 9.304) Pub Date : 2023-09-28 Naohito Ito, Mayumi Tsuji, Naoki Adachi, Shiro Nakamura, Avijite Kumer Sarkar, Kensuke Ikenaka, César Aguirre, Atsushi Michael Kimura, Yuji Kiuchi, Hideki Mochizuki, David B. Teplow, Kenjiro Ono
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Longitudinal associations between higher self-reported energy, gait speed and cognition in older adults with fatigue J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-29 Rebecca Ehrenkranz, Xiaonan Zhu, Nancy W Glynn, Marnie Bertolet, Sarah B Berman, James B Hengenius, Caterina Rosano
Background Older adults reporting higher energy levels have better physical function. It is not known if these associations persist among older adults reporting fatigue or if higher energy is associated with cognitive function. We examined longitudinal associations between self-reported energy, gait speed, and cognition, stratified by fatigue, in 2,613 participants (aged 74.6 ± 2.87 years) in the Health
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The effect of COVID-19 vaccination status on all-cause mortality in patients hospitalised with COVID-19 in Hungary during the delta wave of the pandemic Geroscience (IF 5.6) Pub Date : 2023-09-27 Viktor J. Horvath, Magdolna Békeffy, Zsuzsanna Németh, Emese Szelke, Vince Fazekas-Pongor, Noémi Hajdu, Márk M. Svébis, József Pintér, Beatrix A. Domján, Szilvia Mészáros, Anna E. Körei, Árpád Kézdi, Ibolya Kocsis, Katalin Kristóf, Péter Kempler, Ferenc Rozgonyi, István Takács, Adam G. Tabák
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Cellular metabolic pathways of aging in dogs: could p53 and SIRT1 be at play? Geroscience (IF 5.6) Pub Date : 2023-09-28 Ana Gabriela Jiménez, Kailey D. Paul, Mitchel Benson, Sahil Lalwani, William Cipolli
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Grey-matter correlates of empathy in 4-Repeat Tauopathies npj Parkinsons Dis. (IF 9.304) Pub Date : 2023-09-27 Benedetta Tafuri, Daniele Urso, Salvatore Nigro, Luigi Macchitella, Roberto De Blasi, K. Ray Chaudhuri, Giancarlo Logroscino
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Bleomycin-treated myoblasts undergo p21-associated cellular senescence and have severely impaired differentiation Geroscience (IF 5.6) Pub Date : 2023-09-26 Michael Kamal, Sophie Joanisse, Gianni Parise
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Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes Geroscience (IF 5.6) Pub Date : 2023-09-26 Laura R. Bramwell, Lorna W. Harries
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Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation Geroscience (IF 5.6) Pub Date : 2023-09-26 Carmen M. Ramos, Sean P. Curran
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Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice Geroscience (IF 5.6) Pub Date : 2023-09-25 Benjamin A. Seitzman, Francisco J. Reynoso, Timothy J. Mitchell, Annie R. Bice, Anmol Jarang, Xiaodan Wang, Cedric Mpoy, Lori Strong, Buck E. Rogers, Carla M. Yuede, Joshua B. Rubin, Stephanie M. Perkins, Adam Q. Bauer
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Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors Geroscience (IF 5.6) Pub Date : 2023-09-25 Blaise L. Mariner, Antonio S. Rodriguez, Olivia C. Heath, Mark A. McCormick
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Risk, protective, and biomarkers of dementia in Indigenous peoples: A systematic review Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-25 Huong X. T. Nguyen, Kate Bradley, Bridgette J. McNamara, Rosie Watson, Roslyn Malay, Dina LoGiudice
Dementia is an emergent health priority for Indigenous peoples worldwide, yet little is known about disease drivers and protective factors.
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Preoperative frailty is an independent risk factor for postinduction hypotension in older patients undergoing noncardiac surgery: a retrospective cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-26 Hyun Jung Lee, Youn Jin Kim, Jae Hee Woo, Hye-Won Oh
Background Intraoperative hypotension is a risk factor for perioperative adverse outcomes and highly prevalent in older patients. Frailty has been associated with hemodynamic instability but its impact on postinduction hypotension is unclear. Therefore, we assessed the association between frailty and postinduction hypotension in older patients. Methods We retrospectively evaluated electronic medical
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The effects of a new immersive multidomain training on cognitive, dual-task and physical functions in older adults Geroscience (IF 5.6) Pub Date : 2023-09-25 Néva Béraud-Peigné, Pauline Maillot, Alexandra Perrot
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Sex difference in brain functional connectivity of hippocampus in Alzheimer’s disease Geroscience (IF 5.6) Pub Date : 2023-09-25 Jordan Williamson, Shirley A. James, Peter Mukli, Andriy Yabluchanskiy, Dee H. Wu, William Sonntag, Yuan Yang
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Sex differences in biological aging and the association with clinical measures in older adults Geroscience (IF 5.6) Pub Date : 2023-09-25 Aung Zaw Zaw Phyo, Peter D. Fransquet, Jo Wrigglesworth, Robyn L. Woods, Sara E. Espinoza, Joanne Ryan
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Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-23 Olivia Wagemann, Yan Li, Jason Hassenstab, Andrew J. Aschenbrenner, Nicole S. McKay, Brian A. Gordon, Tammie L. S. Benzinger, Chengjie Xiong, Carlos Cruchaga, Alan E. Renton, Richard J. Perrin, Sarah B. Berman, Jasmeer P. Chhatwal, Martin R. Farlow, Gregory S. Day, Takeshi Ikeuchi, Mathias Jucker, Francisco Lopera, Hiroshi Mori, James M. Noble, Raquel Sánchez-Valle, Peter R. Schofield, John C. Morris
Studies suggest distinct differences in the development, presentation, progression, and response to treatment of Alzheimer's disease (AD) between females and males. We investigated sex differences in cognition, neuroimaging, and fluid biomarkers in dominantly inherited AD (DIAD).
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ATN cerebrospinal fluid biomarkers in dementia with Lewy bodies: Initial results from the United States Dementia with Lewy Bodies Consortium Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-23 Lavanya Jain, Maria Khrestian, Shane Formica, Elizabeth D. Tuason, Jagan A. Pillai, Stephen Rao, Odinachi Oguh, Carol F. Lippa, Oscar L. Lopez, Sarah B. Berman, Debby W. Tsuang, Cyrus P. Zabetian, David J. Irwin, Douglas R. Galasko, Irene Litvan, Karen S. Marder, Lawrence S. Honig, Jori E. Fleisher, James E. Galvin, Andrea C. Bozoki, Angela S. Taylor, Marwan N. Sabbagh, James B. Leverenz, Lynn M. Bekris
The National Institute on Aging – Alzheimer's Association (NIA-AA) ATN research framework proposes to use biomarkers for amyloid (A), tau (T), and neurodegeneration (N) to stage individuals with AD pathological features and track changes longitudinally. The overall aim was to utilize this framework to characterize pre-mortem ATN status longitudinally in a clinically diagnosed cohort of dementia with
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Sex differences in risk factors, burden, and outcomes of cerebrovascular disease in Alzheimer's disease populations Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-21 Cassandra Morrison, Mahsa Dadar, Donald Louis Collins
White matter hyperintensities (WMHs) are associated with cognitive decline and progression to mild cognitive impairment (MCI) and dementia. It remains unclear if sex differences influence WMH progression or the relationship between WMH and cognition.
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Investigating predictors of progression from mild cognitive impairment to Alzheimer’s disease based on different time intervals Age Ageing (IF 6.7) Pub Date : 2023-09-24 Yafei Wu, Xing Wang, Chenming Gu, Junmin Zhu, Ya Fang
Background Mild cognitive impairment (MCI) is the early stage of AD, and about 10–12% of MCI patients will progress to AD every year. At present, there are no effective markers for the early diagnosis of whether MCI patients will progress to AD. This study aimed to develop machine learning-based models for predicting the progression from MCI to AD within 3 years, to assist in screening and prevention
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Differential behavioral aging trajectories according to body size, expected lifespan, and head shape in dogs Geroscience (IF 5.6) Pub Date : 2023-09-23 Borbála Turcsán, Enikő Kubinyi
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Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions npj Parkinsons Dis. (IF 9.304) Pub Date : 2023-09-23 Meraj Ramezani, Alice Wagenknecht-Wiesner, Tong Wang, David A. Holowka, David Eliezer, Barbara A. Baird
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Challenges and improvements associated with transitions between hospitals and care homes during the COVID-19 pandemic: a qualitative study with care home and healthcare staff in England Age Ageing (IF 6.7) Pub Date : 2023-09-23 Craig Newman, Stephanie Mulrine, Katie Brittain, Pamela Dawson, Celia Mason, Michele Spencer, Kate Sykes, Frazer Underwood, Lesley Young-Murphy, Justin Waring, Jason Scott
Background Care home residents transitioning from hospital are at risk of receiving poor-quality care with their safety being challenged by the SARS-CoV-2 virus (COVID-19) pandemic. Little is known about how care home staff worked with hospital staff and other healthcare professionals to address these challenges and make improvements to increase patient safety. Objective To gain insight into how the
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Plant-based dietary patterns and the risk of dementia: a population-based study Age Ageing (IF 6.7) Pub Date : 2023-09-23 Tosca O E de Crom, Marinka Steur, M Kamran Ikram, M Arfan Ikram, Trudy Voortman
Background Plant-based dietary patterns are increasingly popular in western countries and are supported by many governments and health organisations for their potential beneficial role in the prevention of chronic diseases. Yet, the potential role of plant-based dietary patterns in the development of dementia remains unclear. Objective To evaluate the association between plant-based dietary patterns
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‘Auspicious liaisons’—evaluating the impact of a liaison geriatrician initiative on older adults psychiatric wards Age Ageing (IF 6.7) Pub Date : 2023-09-23 Peter Swann, Abraham Tolley, Theodoros Paschalis, Daniel Zahedi, Heng C Wong, Viveca Kirthisingha, Eladia Ruiz-Mendoza, Judy Rubinsztein
Background Although liaison services in acute hospitals are now the norm, the reverse is not usually available for patients in mental health trusts. Following the introduction of support from geriatricians to older people’s mental health inpatient wards, we wanted to see if this intervention was effective and acceptable to clinicians. Methods We performed a retrospective cohort service evaluation on
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Interventions for reducing anticholinergic medication burden in older adults—a systematic review and meta-analysis Age Ageing (IF 6.7) Pub Date : 2023-09-23 Eve Braithwaite, Oliver M Todd, Abigail Atkin, Rachel Hulatt, Ragy Tadrous, David P Alldred, Munir Pirmohamed, Lauren Walker, Rebecca Lawton, Andrew Clegg
Introduction Anticholinergic medications block the neurotransmitter acetylcholine in the brain and peripheral nervous system. Many medications have anticholinergic properties, and the cumulative effect of these medications is termed anticholinergic burden. Increased anticholinergic burden can have short-term side effects such as dry mouth, blurred vision and urinary retention as well as long-term effects
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The effectiveness of community-based palliative care programme components: a systematic review Age Ageing (IF 6.7) Pub Date : 2023-09-23 M Courtney Hughes, Erin Vernon, Allison Hainstock
Background There is evidence that community-based palliative care programmes can improve patient outcomes and caregiver experiences cost-effectively. However, little is known about which specific components within these programmes contribute to improving the outcomes. Aim To systematically review research that evaluates the effectiveness of community-based palliative care components. Design A systematic
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Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging Geroscience (IF 5.6) Pub Date : 2023-09-20 Muhammad Arif, Csaba Matyas, Partha Mukhopadhyay, Burhan Yokus, Eszter Trojnar, Janos Paloczi, Bruno Paes-Leme, Suxian Zhao, Falk W. Lohoff, György Haskó, Pal Pacher
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Artificial light and neurodegeneration: does light pollution impact the development of Alzheimer’s disease? Geroscience (IF 5.6) Pub Date : 2023-09-21 Julia Karska, Szymon Kowalski, Anna Gładka, Anna Brzecka, Marta Sochocka, Donata Kurpas, Jan Aleksander Beszłej, Jerzy Leszek
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Aging-Related Mitochondrial Dysfunction is Associated with Fibrosis in Benign Prostatic Hyperplasia J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-22 Alexis E Adrian, Teresa T Liu, Laura E Pascal, Scott R Bauer, Donald B DeFranco, William A Ricke
Background Age is the greatest risk factor for lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). While LUTS/BPH can be managed with pharmacotherapy, treatment failure has been putatively attributed to numerous pathological features of BPH (e.g., prostatic fibrosis, inflammation). Mitochondrial dysfunction is a hallmark of aging, however its impact on the pathological
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Brain age prediction across the human lifespan using multimodal MRI data Geroscience (IF 5.6) Pub Date : 2023-09-21 Sihai Guan, Runzhou Jiang, Chun Meng, Bharat Biswal
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Differential predictability of cognitive profiles from brain structure in older males and females Geroscience (IF 5.6) Pub Date : 2023-09-21 Christiane Jockwitz, Camilla Krämer, Paulo Dellani, Svenja Caspers
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Deep neural network-estimated age using optical coherence tomography predicts mortality Geroscience (IF 5.6) Pub Date : 2023-09-21 Ruiye Chen, Shiran Zhang, Guankai Peng, Wei Meng, Grace Borchert, Wei Wang, Zhen Yu, Huan Liao, Zongyuan Ge, Mingguang He, Zhuoting Zhu
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Uncovering the neurophysiology of mood, motivation and behavioral symptoms in Parkinson’s disease through intracranial recordings npj Parkinsons Dis. (IF 9.304) Pub Date : 2023-09-21 Lucia Ricciardi, Matthew Apps, Simon Little
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Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain npj Parkinsons Dis. (IF 9.304) Pub Date : 2023-09-19 Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erwan Bezard, Benjamin Dehay
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Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-19 Katia de Paiva Lopes, Lei Yu, Xianli Shen, Yiguo Qiu, Shinya Tasaki, Artemis Iatrou, Michal Schnaider Beeri, Nicholas T. Seyfried, Vilas Menon, Yanling Wang, Julie A. Schneider, Harvey Cantor, David A. Bennett
The secreted phosphoprotein 1 (SPP1) gene expressed by CD11c+ cells is known to be associated with microglia activation and neuroinflammatory diseases. As most studies rely on mouse models, we investigated these genes and proteins in the cortical brain tissue of older adults and their role in Alzheimer's disease (AD) and related disorders.
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Risk of cognitive decline progression is associated to increased blood-brain-barrier permeability: A longitudinal study in a memory unit clinical cohort Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-19 Albert Puig-Pijoan, Joan Jimenez-Balado, Aida Fernández-Lebrero, Greta García-Escobar, Irene Navalpotro-Gómez, Jose Contador, Rosa-María Manero-Borràs, Victor Puente-Periz, Antoni Suárez, Francisco J. Muñoz, Oriol Grau-Rivera, Marc Suárez-Calvet, Rafael de la Torre, Jaume Roquer, Angel Ois
This study examined the relationship between blood-brain-barrier permeability (BBBp), measured by cerebrospinal fluid/serum albumin ratio (QAlb), and cognitive decline progression in a clinical cohort.
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Inadequate reimbursement for lumbar puncture is a potential barrier to accessing new Alzheimer's disease treatments Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-18 Samuele Bonomi, Mahendra R. Gupta, Suzanne E. Schindler
Alzheimer's disease (AD) is the most common cause of dementia1 and is characterized by the deposition of amyloid plaques and tau neurofibrillary tangles in the brain, which are thought to initiate a cascade leading to progressive neurodegeneration and cognitive impairment. The U.S. Food and Drug Administration (FDA) recently approved lecanemab after it was demonstrated to slow cognitive decline in
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Health care utilization and costs in the years preceding dementia identification Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-18 Raj G. Kumar, Evan Bollens Lund, Katherine A. Ornstein, Jing Li, Kenneth E. Covinsky, Amy S. Kelley
There is evidence that health care utilization increases after incident dementia, particularly after dementia diagnosis and toward the end of life; however, less is known about utilization in the years before dementia identification.
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Protein restriction effects on health-span and lifespan in Drosophila melanogaster are additive with a longevity-promoting diet J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-21 Wei Zhang, Yunshuang Ye, Yinan Sun, Yongxuan Li, Mingxia Ge, Kangning Chen, Liping Yang, Guijun Chen, Jumin Zhou
Aging of the organism is associated diminished response to external stimuli including weakened immune function, resulting in diseases that impair health and lifespan. Several dietary restriction modalities have been reported to improve health and lifespan in different animal models, but it is unknown whether any of the lifespan extending dietary treatment could be combined to achieve an additive effect
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Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort Geroscience (IF 5.6) Pub Date : 2023-09-19 Shunsuke Murata, Marcus Ebeling, Anna C. Meyer, Katharina Schmidt-Mende, Niklas Hammar, Karin Modig
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Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study Geroscience (IF 5.6) Pub Date : 2023-09-16 Bastian Kochlik, Catrin Herpich, María Moreno-Villanueva, Susanne Klaus, Ursula Müller-Werdan, Birgit Weinberger, Simone Fiegl, Olivier Toussaint, Florence Debacq-Chainiaux, Christiane Schön, Jürgen Bernhard, Nicolle Breusing, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Ewa Sikora, Antti Hervonen, Mikko Hurme, P. Eline Slagboom, Martijn E. T. Dollé, Eugene Jansen, Tilman Grune, Alexander
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Living Longer But Frailer? Temporal Trends in Life Expectancy and Frailty in Older Swedish Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-19 Clare Tazzeo, Debora Rizzuto, Amaia Calderón-Larrañaga, Serhiy Dekhtyar, Alberto Zucchelli, Xin Xia, Laura Fratiglioni, Davide Liborio Vetrano
Background This study aims to examine temporal trends in frailty state transitions, and years spent frail, in older Swedish adults. Methods We followed the Swedish National Study on Aging and Care in Kungsholmen participants from baseline (2001–2004) for 15 (median: 9.6) years. A 40-deficit frailty index (FI) was constructed to identify 3 frailty states: robust (FI ≤ 0.125), mild frailty (0.125 < FI
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Caloric restriction intervention alters specific circulating biomarkers of the senescence-associated secretome in middle-aged and older adults with obesity and prediabetes in an 18-week randomized controlled trial J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-19 Jamie N Justice, Iris Leng, Nathan K LeBrasseur, Tamara Tchkonia, James L Kirkland, Natalia Mitin, Yongmei Liu, Stephen B Kritchevsky, Barbara J Nicklas, Jingzhong Ding
Cellular senescence is a biological aging process that is exacerbated by obesity and leads to inflammation and age- and obesogenic-driven chronic diseases including type 2 diabetes. Caloric restriction (CR) may improve metabolic function in part by reducing cellular senescence and the pro-inflammatory senescence-associated phenotype (SASP). We conducted an ancillary investigation of an 18-week randomized
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Reliability of the frailty index among community-dwelling older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-19 Erwin Stolz, Hannes Mayerl, Judith Godin, Emiel O Hoogendijk, Olga Theou, Wolfgang Freidl, Kenneth Rockwood
Background Consistent and reproducible estimates of the underlying true level of frailty are essential for risk stratification and monitoring of health changes. The purpose of this study is to examine the reliability of the frailty index (FI). Methods 426 community-dwelling older adults from the FRequent health Assessment In Later life (FRAIL70+) study in Austria were interviewed biweekly up to 7 times
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Cardiovascular Disorders and Falls Among Older Adults: A Systematic Review and Meta-Analysis J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-19 Robbie Bourke, Paul Doody, Sergio Pérez, David Moloney, Lewis Lipsitz, Rose Anne Kenny
Background Falls are a common cause of injury, hospitalisation, functional decline, and residential care admission among older adults. Cardiovascular disorders are recognised risk factors for falls. This systematic review assesses the association between cardiovascular disorders and falls in older adults. Methods Systematic searches were conducted on MEDLINE and EMBASE, encompassing all literature
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Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release Geroscience (IF 5.6) Pub Date : 2023-09-18 Sharmin Aktar, Farhana Ferdousi, Shinji Kondo, Tamami Kagawa, Hiroko Isoda
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The Triple Alliance: Microbiome, Mitochondria, and Metabolites in the Context of Age-Related Cognitive Decline and Alzheimer's Disease J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2023-09-18 Santosh K Prajapati, Ria Shah, Nicholas Alford, Sidharth P Mishra, Shalini Jain, Barbara Hansen, Paul Sanburg, Anthony J A Molina, Hariom Yadav
Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder that affects a large proportion of the elderly population. It currently lacks effective treatments, placing a heavy burden on patients, families, healthcare systems, and society. This is mainly due to our limited comprehension of the pathophysiology of AD progression, as well as the lack of effective drug targets and
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Exploring the link between essential tremor and Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2023-09-15 Sang-Won Yoo, Seunggyun Ha, Chul Hyoung Lyoo, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Kim
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Salidroside promotes healthy longevity by interfering with HSP90 activity Geroscience (IF 5.6) Pub Date : 2023-09-15 Jianfei Zhang, Zhiquan Li, Jiangbo Song, Lei Zhou, Xin Chen, Wen Ge, Tianyi Dong, Yuxin Luo, Ting Mao, Zheng Li, Duan Tan, Lene Juel Rasmussen, Vilhelm A. Bohr, Xiaoling Tong, Fangyin Dai
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Regional differences in the link between water exchange rate across the blood–brain barrier and cognitive performance in normal aging Geroscience (IF 5.6) Pub Date : 2023-09-15 Valentinos Zachariou, Colleen Pappas, Christopher E. Bauer, Xingfeng Shao, Peiying Liu, Hanzhang Lu, Danny J. J. Wang, Brian T. Gold
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Associations between psychological resilience and epigenetic clocks in the health and retirement study Geroscience (IF 5.6) Pub Date : 2023-09-14 Aijie Zhang, Yasi Zhang, Yaxian Meng, Qianqian Ji, Meijie Ye, Liqiong Zhou, Miao Liu, Chao Yi, Ida K. Karlsson, Fang Fang, Sara Hägg, Yiqiang Zhan
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The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022 Alzheimers Dement. (IF 14.0) Pub Date : 2023-09-12 Dallas P. Veitch, Michael W. Weiner, Melanie Miller, Paul S. Aisen, Miriam A. Ashford, Laurel A. Beckett, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Susan M. Landau, John C. Morris, Kwangsik T. Nho, Rachel Nosheny, Ozioma Okonkwo, Richard J. Perrin, Ronald C. Petersen, Monica Rivera Mindt, Andrew Saykin, Leslie M. Shaw, Arthur W. Toga, Duygu Tosun
The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging, and cognitive data, and biofluid samples. We used conventional search methods to identify 1459 publications from 2021 to 2022 using ADNI data/samples and reviewed 291 impactful studies. This review details how ADNI studies improved disease