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Dementia and mild cognitive impairment screening in an emergency homeless shelter Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-18 Heather M. Ross, Primrose Dzenga, Martha Myers, Alisa Squires, Stephanie Duncan, Jamilyn Caradine, Phillip Scharf, Diana M. Bowman
Older adults represent the fastest growing segment of the homeless community. Little is known about the prevalence of dementia and mild cognitive impairment (MCI) in this population.
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Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-18 Peng Li, Chenlu Gao, Lei Yu, Lei Gao, Ruixue Cai, David A. Bennett, Julie A. Schneider, Aron S. Buchman, Kun Hu
Degradation of fractal patterns in actigraphy independently predicts dementia risk. Such observations motivated the study to understand the role of fractal regulation in the context of neuropathologies.
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Wrist-worn actigraphy in agitated late-stage dementia patients: A feasibility study on digital inclusion Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-18 Ta-Wei Guu, Anna-Katharine Brem, Christopher P. Albertyn, Pooja Kandangwa, Dag Aarsland, Dominic ffytche
Wrist-worn actigraphy can be an objective tool to assess sleep and other behavioral and psychological symptoms in dementia (BPSD). We investigated the feasibility of using wearable actigraphy in agitated late-stage dementia patients.
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Deriving life-course residential histories in brain bank cohorts: A feasibility study Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-18 Eleanna M. Melcher, Leigha Vilen, Aly Pfaff, Sarah Lim, Amanda DeWitt, W. Ryan Powell, Barbara B. Bendlin, Amy J. H. Kind
The exposome is theorized to interact with biological mechanisms to influence risk for Alzheimer's disease but is not well-integrated into existing Alzheimer's Disease Research Center (ADRC) brain bank data collection.
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Association between hippocampal microglia, AD and LATE-NC, and cognitive decline in older adults Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-17 Alifiya Kapasi, Lei Yu, Sue E Leurgans, Sonal Agrawal, Patricia A Boyle, David A Bennett, Julie A Schneider
This study investigates the relationship between microglia inflammation in the hippocampus, brain pathologies, and cognitive decline.
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Advanced brain aging in Parkinson’s disease with cognitive impairment npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-16 Chang-Le Chen, Shao-Ying Cheng, Leila Montaser-Kouhsari, Wen-Chao Wu, Yung-Chin Hsu, Chun-Hwei Tai, Wen-Yih Isaac Tseng, Ming-Che Kuo, Ruey-Meei Wu
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Long-term safety and efficacy of open-label nabilone on sleep and pain in Parkinson´s Disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-15 Marina Peball, Beatrice Heim, Federico Carbone, Oliver Schorr, Mario Werkmann, Philipp Ellmerer, Kathrin Marini, Florian Krismer, Hans-Günther Knaus, Werner Poewe, Atbin Djamshidian, Klaus Seppi
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Corneal confocal microscopy may help to distinguish Multiple System Atrophy from Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-16 Xuebin Niu, Peixiao Yin, Chenyang Guan, Qiuyue Shao, Guiyun Cui, Kun Zan, Chuanying Xu
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Clinical validation of the PrecivityAD2 blood test: A mass spectrometry‐based test with algorithm combining %p‐tau217 and Aβ42/40 ratio to identify presence of brain amyloid Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-16 Matthew R. Meyer, Kristopher M. Kirmess, Stephanie Eastwood, Traci L. Wente‐Roth, Faith Irvin, Mary S. Holubasch, Venky Venkatesh, Ilana Fogelman, Mark Monane, Lucy Hanna, Gil D. Rabinovici, Barry A. Siegel, Rachel A. Whitmer, Charles Apgar, Randall J. Bateman, David M. Holtzman, Michael Irizarry, David Verbel, Pallavi Sachdev, Satoshi Ito, John Contois, Kevin E. Yarasheski, Joel B. Braunstein, Philip
BACKGROUNDWith the availability of disease‐modifying therapies for Alzheimer's disease (AD), it is important for clinicians to have tests to aid in AD diagnosis, especially when the presence of amyloid pathology is a criterion for receiving treatment.METHODSHigh‐throughput, mass spectrometry‐based assays were used to measure %p‐tau217 and amyloid beta (Aβ)42/40 ratio in blood samples from 583 individuals
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Effects of the active amyloid beta immunotherapy CAD106 on PET measurements of amyloid plaque deposition in cognitively unimpaired APOE ε4 homozygotes Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-16 Marie‐Emmanuelle Riviere, Jessica B. Langbaum, R. Scott Turner, Juha O. Rinne, Yihan Sui, Pilar Cazorla, Javier Ricart, Kathleen Meneses, Angelika Caputo, Pierre N. Tariot, Eric M. Reiman, Ana Graf
INTRODUCTIONAlzheimer's Prevention Initiative Generation Study 1 evaluated amyloid beta (Aβ) active immunotherapy (vaccine) CAD106 and BACE‐1 inhibitor umibecestat in cognitively unimpaired 60‐ to 75‐year‐old participants at genetic risk for Alzheimer's disease (AD). The study was reduced in size and terminated early. Results from the CAD106 cohort are presented.METHODSSixty‐five apolipoprotein E ε4
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Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-15 Guy Hajj-Boutros, Andréa Faust, John Muscedere, Perry Kim, Naji Abumrad, Stéphanie Chevalier, Mylene Aubertin-Leheudre, Howard Bergman, Dawn Bowdish, Jessica Burford, Stacy Carrington-Lawrence, Hélène Côté, David E Dawe, Philipe de Souto Barreto, Colin Farrelly, Robert Fowler, Gilles Gouspillou, Lea Harrington, Sofie Lautrup, Susan Howlett, Mahdi Imani, James Kirkland, George Kuchel, Frédérick A Mallette
The inaugural Canadian Conferences on Translational Geroscience were held as two complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social determinants of health, the potential societal impact of geroscience and the maintenance of health in aging individuals. Although topics such as cellular senescence, molecular and genetic
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Disease progression strikingly differs in research and real-world Parkinson’s populations npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-13 Brett K. Beaulieu-Jones, Francesca Frau, Sylvie Bozzi, Karen J. Chandross, M. Judith Peterschmitt, Caroline Cohen, Catherine Coulovrat, Dinesh Kumar, Mark J. Kruger, Scott L. Lipnick, Lane Fitzsimmons, Isaac S. Kohane, Clemens R. Scherzer
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Possible role of lncRNAs in amelioration of Parkinson’s disease symptoms by transplantation of dopaminergic cells npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-12 A. Amini, F. Esmaeili, M. Golpich
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Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-13 J. Matthijs Biesbroek, Mirthe Coenen, Charles DeCarli, Evan M. Fletcher, Pauline M. Maillard, , Frederik Barkhof, Josephine Barnes, Thomas Benke, Christopher P. L. H. Chen, Peter Dal-Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G. Exalto, Nicolai Franzmeier, Saima Hilal, Edith Hofer, Huiberdina L. Koek, Andrea B. Maier, Cheryl R. McCreary, Janne M. Papma, Ross W. Paterson
White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid-β1-42 (Aβ42)-positive status.
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Dementia, dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth‐cohort geographic analyses Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-14 Aaron Reuben, Leah S. Richmond‐Rakerd, Barry Milne, Devesh Shah, Amber Pearson, Sean Hogan, David Ireland, Ross Keenan, Annchen R. Knodt, Tracy Melzer, Richie Poulton, Sandhya Ramrakha, Ethan T. Whitman, Ahmad R. Hariri, Terrie E. Moffitt, Avshalom Caspi
INTRODUCTIONDementia risk may be elevated in socioeconomically disadvantaged neighborhoods. Reasons for this remain unclear, and this elevation has yet to be shown at a national population level.METHODSWe tested whether dementia was more prevalent in disadvantaged neighborhoods across the New Zealand population (N = 1.41 million analytic sample) over a 20‐year observation. We then tested whether premorbid
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Correction to Association of Gut Microbiome with Diabetes Mellitus and Alzheimer's Disease in a Puerto Rican Adult Population: A Preliminary Report Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-14
Cecilia Michelle Soler-Llompart, Filipa Godoy-Vitorino, Ana Cecilia Sala-Morales, Michel Santiago-Berríos, Javier A. Ruiz-Adames, Gerianne Olivieri-Henry, Carlos Herrero-Rivera, Fabián J. Pérez-Luzunaris, Vanessa Sepulveda Association of Gut Microbiome with Diabetes Mellitus and Alzheimer's Disease in a Puerto Rican Adult Population: A Preliminary Report Alzheimer's Dement. 2023;19(Suppl. 24):e083053
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Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-14 Hampus Hillerstrom, Richard Fisher, Matthew P. Janicki, Brian Chicoine, Bradley T. Christian, Anna Esbensen, Lucille Esralew, Juan Fortea, Sigan Hartley, Jason Hassenstab, Seth M. Keller, Sharon Krinsky‐McHale, Florence Lai, Johannes Levin, Mary McCarron, Eric McDade, Anne Sophie Rebillat, Herminia Diana Rosas, Wayne Silverman, Andre Strydom, Shahid H. Zaman, Henrik Zetterberg
Prior authorization criteria for Federal Drug Administration (FDA) approved immunotherapeutics, among the class of anti‐amyloid monoclonal antibodies (mAbs), established by state drug formulary committees, are tailored for adults with late‐onset Alzheimer's disease. This overlooks adults with Down syndrome (DS), who often experience dementia at a younger age and with different diagnostic assessment
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Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-12 Ryota Sakurai, Frederico Pieruccini-Faria, Benjamin Cornish, Julia Fraser, Malcolm A. Binns, Derek Beaton, Allison Ann Dilliott, Donna Kwan, Joel Ramirez, Brian Tan, Christopher J. M. Scott, Kelly M. Sunderland, Carmela Tartaglia, Elizabeth Finger, Lorne Zinman, Morris Freedman, Paula M. McLaughlin, Richard H. Swartz, Sean Symons, Anthony E. Lang, Robert Bartha, Sandra E. Black, Mario Masellis, Robert
Apolipoprotein E E4 allele (APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its underlying mechanism in neurodegenerative diseases.
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Racial and ethnic differences in the association between depressive symptoms and cognitive outcomes in older adults: Findings from KHANDLE and STAR Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-13 Marcia P. Jimenez, Emma L. Gause, Kendra D. Sims, Eleanor Hayes‐Larson, Emily P. Morris, Evan Fletcher, Jennifer Manly, Paola Gilsanz, Yenee Soh, Maria Corrada, Rachel A. Whitmer, Medellena Maria Glymour
INTRODUCTIONDepressive symptoms are associated with higher risk of dementia, but how they impact cognition in diverse populations is unclear.METHODSAsian, Black, Latino, or White participants (n = 2227) in the Kaiser Healthy Aging and Diverse Life Experiences (age 65+) and the Study of Healthy Aging in African Americans (age 50+) underwent up to three waves of cognitive assessments over 4 years. Multilevel
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APOE ε4 is associated with decreased synaptic density in cognitively impaired participants Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-13 Kun He, Binyin Li, Jie Wang, Ying Wang, Zhiwen You, Xing Chen, Haijuan Chen, Junpeng Li, Qi Huang, Qihao Guo, Yiyun Henry Huang, Yihui Guan, Kewei Chen, Jun Zhao, Yulei Deng, Fang Xie
INTRODUCTIONWe aimed to investigate the effect of apolipoprotein E4 (APOE) ε4 on synaptic density in cognitively impaired (CI) participants.METHODSOne hundred ten CI participants underwent amyloid positron emission tomography (PET) with 18F‐florbetapir and synaptic density PET with 18F‐SynVesT‐1. We evaluated the influence of APOE ε4 allele on synaptic density and investigated the effects of ε4 genotype
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Cognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-13 Chiara Pappalettera, Claudia Carrarini, Francesca Miraglia, Fabrizio Vecchio, Paolo M. Rossini
INTRODUCTIONThis review examines the concept of cognitive reserve (CR) in relation to brain aging, particularly in the context of dementia and its early stages. CR refers to an individual's ability to maintain or regain cognitive function despite brain aging, damage, or disease. Various factors, including education, occupation complexity, leisure activities, and genetics are believed to influence CR
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Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-13 Robert Howard, Elizabeth Cort, Charlotte Rawlinson, Martin Wiegand, Anne Downey, Vanessa Lawrence, Sube Banerjee, Peter Bentham, Chris Fox, Rowan Harwood, Rachel Hunter, Gill Livingston, Esme Moniz‐Cook, Monica Panca, Malgorzata Raczek, Chineze Ivenso, Gregor Russell, Alan Thomas, Philip Wilkinson, Nicholas Freemantle, Rebecca Gould
INTRODUCTIONTrials of effectiveness of treatment options for depression in dementia are an important priority.METHODSRandomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in mild/moderate dementia caused by Alzheimer's disease.RESULTSThree hundred thirty‐six participants with mild or moderate dementia, >7 on Cornell Scale for Depression in Dementia (CSDD), randomized
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Strategies to increase the coverage of influenza and pneumonia vaccination in older adults: a systematic review and network meta-analysis Age Ageing (IF 6.7) Pub Date : 2024-03-13 Peipei Du, Shuyan Jin, Shuya Lu, Li Wang, Xiaofeng Ma, Jie Wang, Runting Huang, Qingyue Luo, Shu Yang, Xixi Feng
Background It is urgent to implement interventions to increase vaccination rates of influenza/pneumonia vaccines in older adults, yet the effectiveness of different intervention strategies has not been thoroughly evaluated. Objective We aimed to assess the effectiveness of intervention strategies for increasing the coverage of influenza/pneumonia vaccination in older adults. Methods PubMed, Web of
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Cost-effectiveness of proactive health support—telephone-based self-management support compared with standard care for persons at risk of hospital admission Age Ageing (IF 6.7) Pub Date : 2024-03-13 Maja Kjær Rasmussen, Kirstine Skov Benthien, Camilla Palmhøj Nielsen, Knud Rasmussen, Mette Grønkjær, Ulla Toft, Kristian Kidholm
Background A small share of patients account for a large proportion of costs to the healthcare system in Denmark as in many Western countries. A telephone-based self-management support, proactive health support (PaHS), was suggested for prevention of hospitalisations for persons at risk of hospital admission. These persons have chronic diseases, unplanned hospitalisations and age ≥ 65 years. However
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Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-11 K. C. Summa, P. Jiang, P. González-Rodríguez, X. Huang, X. Lin, M. H. Vitaterna, Y. Dan, D. J. Surmeier, F. W. Turek
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Genetic associations with dementia-related proteinopathy: Application of item response theory Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-09 Yuriko Katsumata, David W. Fardo, Lincoln M. P. Shade, Xian Wu, Shama D. Karanth, Timothy J. Hohman, Julie A. Schneider, David A. Bennett, Jose M. Farfel, Kathryn Gauthreaux, Charles Mock, Walter A. Kukull, Erin L. Abner, Peter T. Nelson,
Although dementia-related proteinopathy has a strong negative impact on public health, and is highly heritable, understanding of the related genetic architecture is incomplete.
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Person‐specific differences in ubiquitin‐proteasome mediated proteostasis in human neurons Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-12 Yi‐Chen Hsieh, Zachary M. Augur, Mason Arbery, Nancy Ashour, Katharine Barrett, Richard V. Pearse, Earvin S. Tio, Duc M. Duong, Daniel Felsky, Philip L. De Jager, David A. Bennett, Nicholas T. Seyfried, Tracy L. Young‐Pearse
BACKGROUNDImpairment of the ubiquitin‐proteasome system (UPS) has been implicated in abnormal protein accumulation in Alzheimer's disease. It remains unclear if genetic variation affects the intrinsic properties of neurons that render some individuals more vulnerable to UPS impairment.METHODSInduced pluripotent stem cell (iPSC)‐derived neurons were generated from over 50 genetically variant and highly
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Increased Risk of New-Onset Parkinson’s Disease Following a Diagnosis of Retinal Vascular Occlusion: A 14-year Cohort Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Seung Hoon Kim, Minah Park, Sung Hoon Jeong
Background Although the role of the vascular component in the pathophysiology of Parkinson’s disease is widely accepted and retinal vascular abnormalities are commonly observed in Parkinson’s disease patients, evidence connecting retinal vascular disorders with the risk of developing Parkinson’s disease is limited. We aimed to investigate the association between retinal vascular occlusion and the risk
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Loneliness, living alone and risk of cardiovascular disease among older adults in China J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Siyue Tan, Dong Liu, Yuyi Zhang, Shengnan Li, Ke Zhang, Zaixiang Tang, Hui Zuo
Background Older adults are prone to live alone and feel lonely. The main objective of this study was to assess the associations of loneliness and living alone with cardiovascular disease (CVD) among community-dwelling older individuals in China. Methods We conducted a longitudinal analysis on 3661 participants aged over 65 years from the latest 2014 and 2018 waves of the Chinese Longitudinal Healthy
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Pain characteristics and progression to sarcopenia in Chinese middle-aged and older adults: a 4-year longitudinal study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Jintao Chen, Liying Yan, Jingjing Chu, Xinyi Wang, Zherong Xu
Background It is imperative for public health to identify the factors that contribute to the progression of sarcopenia among middle-aged and older adults. Our study aimed to investigate the association between pain characteristics and the progression to sarcopenia and its subcomponents among middle-aged and older adults in China. Methods We included 5568 participants from the China Health and Retirement
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Modulation of DBS-induced cortical responses and movement by the directionality and magnitude of current administered npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-08 Rachel K. Spooner, Baccara J. Hizli, Bahne H. Bahners, Alfons Schnitzler, Esther Florin
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Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-06 Yingchuan Chen, Guanyu Zhu, Tianshuo Yuan, Ruoyu Ma, Xin Zhang, Fangang Meng, Anchao Yang, Tingting Du, Jianguo Zhang
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Rural‐urban disparities in the diagnosis and treatment of hypertension and diabetes among aging Indians Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-09 Pooja Rai, Pravin Sahadevan, Abhishek L. Mensegere, Thomas G. Issac, Graciela Muniz‐Terrera, Jonas S. Sundarakumar
INTRODUCTIONHypertension and diabetes are modifiable risk factors for dementia. We aimed to assess rural‐urban disparities in the diagnosis and treatment of these conditions among aging Indians.METHODSParticipants (n = 6316) were from two parallel, prospective aging cohorts in rural and urban India. Using self‐report and clinical/biochemical assessments, we subdivided participants with diabetes and
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BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-09 Laura Fernandez Garcia‐Agudo, Zechuan Shi, Ian F. Smith, Enikö A. Kramár, Katelynn Tran, Shimako Kawauchi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai‐Xuan Shi, Jonathan Neumann, Heidi Yahan Liang, Celia Da Cunha, Giedre Milinkeviciute, Samuel Morabito, Emily Miyoshi, Narges Rezaie, Angela Gomez‐Arboledas, Adrian Mendoza Arvilla, Daryan Iman Ghaemi, Andrea J. Tenner, Frank M. LaFerla, Marcelo
INTRODUCTIONThe BIN1 coding variant rs138047593 (K358R) is linked to Late‐Onset Alzheimer's Disease (LOAD) via targeted exome sequencing.METHODSTo elucidate the functional consequences of this rare coding variant on brain amyloidosis and neuroinflammation, we generated BIN1K358R knock‐in mice using CRISPR/Cas9 technology. These mice were subsequently bred with 5xFAD transgenic mice, which serve as
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Promoting diverse perspectives: Addressing health disparities related to Alzheimer's and all dementias Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-09 Gladys Maestre, Carl Hill, Percy Griffin, Stephen Hall, William Hu, Jason Flatt, Ganesh Babulal, Roland Thorpe, J. Neil Henderson, Dedra Buchwald, Spero Manson, Ethan Cicero, Andrea Gilmore‐Bykovskyi, Alyssa Gamaldo, Crystal Glover, Lisa Barnes, Amy Kind, Bryan James, Adina Zeki Al Hazzouri, Whitney Wharton, Paulo Caramelli, Sarah Szanton, Rachel Whitmer, Jada Benn Torres, Kacie Deters, Ozioma Okonkwo
Dementia research lacks appropriate representation of diverse groups who often face substantial adversity and greater risk of dementia. Current research participants are primarily well‐resourced, non‐Hispanic White, cisgender adults who live close to academic medical centers where much of the research is based. Consequently, the field faces a knowledge gap about Alzheimer's‐related risk factors in
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Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-07 Marinus Fislage, Stefan Winzeck, Rebecca Woodrow, Florian Lammers-Lietz, Emmanuel A. Stamatakis, Marta M. Correia, Jacobus Preller, Insa Feinkohl, Jeroen Hendrikse, Tobias Pischon, Claudia D. Spies, Arjen J. C. Slooter, Georg Winterer, David K. Menon, Norman Zacharias
Structural disconnectivity was found to precede dementia. Global white matter abnormalities might also be associated with postoperative delirium (POD).
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Data stewardship in FTLD research: Investigator and research participant views Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-08 Jalayne J. Arias, Ana M. Tyler, Laura M. Beskow, Maria C. Carillo, Susan Dickinson, Jill Goldman, Mary A. Majumder, Michelle M. Mello, Heather M. Snyder, Jennifer S. Yokoyama
INTRODUCTIONFederal policies and guidelines have expanded the return of individual results to participants and expectations for data sharing between investigators and through repositories. Here, we report investigators’ and study participants’ views and experiences with data stewardship practices within frontotemporal lobal degeneration (FTLD) research, which reveal unique ethical challenges.METHODSSemi‐structured
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Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-07 Diego Sepulveda‐Falla, Jorge I. Vélez, Natalia Acosta‐Baena, Ana Baena, Sonia Moreno, Susanne Krasemann, Francisco Lopera, Claudio A. Mastronardi, Mauricio Arcos‐Burgos
INTRODUCTIONRate of cognitive decline (RCD) in Alzheimer's disease (AD) determines the degree of impairment for patients and of burden for caretakers. We studied the association of RCD with genetic variants in AD.METHODSRCD was evaluated in 62 familial AD (FAD) and 53 sporadic AD (SAD) cases, and analyzed by whole‐exome sequencing for association with common exonic functional variants. Findings were
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Association receives $25 million grant to enhance respite care for dementia caregivers Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-07
The Administration for Community Living, a division of the U.S. Department of Health and Human Services, has awarded the Alzheimer's Association a $25 million grant to enhance respite services for people living with dementia and their caregivers nationwide. It is the largest grant ever made to the Association. The 5-year grant will establish a new Center for Dementia Respite Innovation (CDRI) led by
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Finding the balance between person-centred and treatment-centred discussions in advance care planning—a qualitative analysis of conversations within the MUTUAL (Multidisciplinary Timely Undertaken Advance Care Planning conversations) intervention using a narrative analysis Age Ageing (IF 6.7) Pub Date : 2024-03-07 Eline V T J van Lummel, Larissa Ietswaard, Marloes Rigter, Dave H T Tjan, Johannes J M van Delden, Megan Milota
Introduction Advance care planning (ACP) aims to create conditions for more person-centred care. We aimed to explore variations in person-centred care discussions and treatment-centred care discussions within ACP conversations in the Multidisciplinary Timely Undertaken Advance Care Planning (MUTUAL) intervention and how person-centred care discussions could be encouraged. The MUTUAL intervention consists
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Lack of Immune-resilience negatively affects Physical-resilience. Results from the InCHIANTI follow-up study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Chiara Mussi, Eleonora Sparvieri, Stefano Volpato, Toshiko Tanaka, Luigi Ferrucci
There is consistent evidence that immune response declines with aging, with wide inter-individual variability and a still unclear relationship with the development of frailty. To address this question we assessed the role of immune resilience (capacity to restore immune functions), operationalized as the neutrophil-to-lymphocytes ratio (NL-ratio) and monocytes-to-lymphocytes ratio (ML-ratio), in the
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Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Päivi Herranen, Kaisa Koivunen, Teemu Palviainen, Urho M Kujala, Samuli Ripatti, Jaakko Kaprio, Elina Sillanpää
Background We used a polygenic score for hand grip strength (PGS HGS) to investigate whether genetic predisposition for higher muscle strength predicts age-related noncommunicable diseases, survival from acute adverse health events, and mortality. Methods This study consisted of 342 443 Finnish biobank participants from FinnGen Data Freeze 10 (53% women) aged 40 to 108 with combined genotype and health
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Effects of Multicomponent Home-Based Intervention on Muscle Composition, Fitness and Bone Density after Hip Fracture J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Alice S Ryan, Brock A Beamer, Ann L Gruber-Baldini, Rebecca L Craik, Justine Golden, Jack Guralnik, Marc C Hochberg, Kathleen K Mangione, Denise Orwig, Alan M Rathbun, Jay Magaziner
Background Mechanistic factors on the pathway to improving independent ambulatory ability among hip fracture patients by a multicomponent home-based physical therapy intervention that emphasized aerobic, strength, balance, and functional training are unknown. The aim of this study was to determine the effects of two different home-based physical therapy programs on muscle area and attenuation (reflects
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Association of combined healthy lifestyle factors with incident dementia in participants with and without multimorbidity: a large population-based prospective cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Ying-ying Niu, Jian-feng Zhong, Hui-yan Wen, Hao-yu Yan, Zhi-quan Diao, Jia-xin Li, Xue-rui Bai, Jia-min Qiu, Zhi-tong Xu, Lian-hong Chen, Cheng-ping Li, Jing Li, Xiao-feng Liang, Dan Liu
BACKGROUND The effect of a healthy lifestyle on dementia associated with multimorbidity-related is not well-understood. Our objective is to examine whether the adoption of a healthy lifestyle could potentially reduce the elevated risk of dementia in individuals with and without multimorbidity. METHODS We utilized data from the UK Biobank cohort. A comprehensive healthy lifestyle score, ranging from
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Blood tests for Alzheimer's disease: The impact of disease prevalence on test performance Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-06 Mari L. DeMarco, Alicia Algeciras‐Schimnich, Melissa M. Budelier
Regulatory agencies, including the US Food and Drug Administration, have recently approved Alzheimer's disease (AD) therapies targeting amyloid-beta (Aβ) pathology. This has placed a spotlight on the need for accurate and accessible diagnostic tools for AD pathology. Currently, AD cerebrospinal fluid (CSF) biomarkers and amyloid imaging have regulatory approval in many countries and are routinely used
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Nanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage neurodegeneration Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-06 Dibyadeep Datta, Isabella Perone, Denethi Wijegunawardana, Feng Liang, Yury M. Morozov, Jon Arellano, Alvaro Duque, Zhongcong Xie, Christopher H. van Dyck, Mary Kate P. Joyce, Amy F. T. Arnsten
INTRODUCTIONTau phosphorylated at threonine‐217 (pT217‐tau) is a novel fluid‐based biomarker that predicts onset of Alzheimer's disease (AD) symptoms, but little is known about how pT217‐tau arises in the brain, as soluble pT217‐tau is dephosphorylated post mortem in humans.METHODSWe used multilabel immunofluorescence and immunoelectron microscopy to examine the subcellular localization of early‐stage
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Association between serum NT-proBNP and gray matter atrophy patterns in an older Japanese population: the Hisayama Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-06 Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Taro Nakazawa, Tomoyuki Ohara, Mao Shibata, Fumio Yamashita, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya
Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1,201 community-dwelling Japanese aged ≥65 years.
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Circular RNA circVmn2r1 acts as a miR-223-3p sponge to promote kidney aging by regulating NLRP3 expression in mice J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-06 Fanfan Gao, Limin Wei, Jie Li, Lu Zeng, Meng Wang, Ping Lan, Shanshan Liang, Xinmei Huang, Lei Chen, Hongli Jiang
Kidney aging accelerates the progression of various acute and chronic kidney diseases and can also induce pathological changes in other organs throughout the body. Circular RNAs (circRNAs), have been demonstrated to play a vital role in aging and age-related diseases. However, biological functions and the underlying molecular mechanism of circRNAs in kidney aging remain largely unclear. Uncovering
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Oscillatory and non-oscillatory features of the magnetoencephalic sensorimotor rhythm in Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-05 Mikkel C. Vinding, Josefine Waldthaler, Allison Eriksson, Cassia Low Manting, Daniel Ferreira, Martin Ingvar, Per Svenningsson, Daniel Lundqvist
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Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-05 Jesse C. DeSimone, Wei‐en Wang, David A. Loewenstein, Ranjan Duara, Glenn E. Smith, Karen N. McFarland, Melissa J. Armstrong, Darren M. Weber, Warren Barker, Stephen A. Coombes, David E. Vaillancourt
INTRODUCTIONMagnetic resonance imaging (MRI) biomarkers are needed for indexing early biological stages of Alzheimer's disease (AD), such as plasma amyloid‐β (Aβ42/40) positivity in Aβ positron emission tomography (PET) negative individuals.METHODSDiffusion free‐water (FW) MRI was acquired in individuals with normal cognition (NC) and mild cognitive impairment (MCI) with Aβ plasma‐/PET‐ (NC = 22, MCI
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Predictors of urinary and faecal incontinence in pre-frail and frail older adults: a cross-sectional study of the FRAGSALUD project J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-04 Juan Corral-Pérez, Laura Ávila-Cabeza-de-Vaca, Inmaculada Valero-Cantero, Andrea González-Mariscal, Jesús G Ponce-González, María Ángeles Vázquez-Sánchez, Cristina Casals
Background Frailty is associated with urinary and faecal incontinence, which are common geriatric syndromes. This study aims to identify health factors associated with incontinence in pre-frail or frail older adults living in the community. Methods This multicentre cross-sectional study included 225 older adults (75.0±6.4 years) with pre-frailty or frailty based on the five-component Fried phenotype
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Plasma GFAP as a prognostic biomarker of motor subtype in early Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-01 Ningning Che, Ruwei Ou, Chunyu Li, Lingyu Zhang, Qianqian Wei, Shichan Wang, Qirui Jiang, Tianmi Yang, Yi Xiao, Junyu Lin, Bi Zhao, Xueping Chen, Huifang Shang
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G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-03-01 Nicholas Pena, Tara Richbourg, Claudia P. Gonzalez-Hunt, Rui Qi, Paul Wren, Carrolee Barlow, Natalie F. Shanks, Holly J. Carlisle, Laurie H. Sanders
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Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-02-29 Silke Nuber, Xiaoqun Zhang, Thomas D. McCaffery, Tim E. Moors, Marie-Alexandre Adom, Wolf N. Hahn, Dylan Martin, Maria Ericsson, Arathi Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J. Selkoe
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Sleep disorders in Parkinson’s disease, an early and multiple problem npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-02-29 Pauline Dodet, Marion Houot, Smaranda Leu-Semenescu, Jean-Christophe Corvol, Stéphane Lehéricy, Graziella Mangone, Marie Vidailhet, Emmanuel Roze, Isabelle Arnulf
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Chewing disability is associated with cognitive impairment among older adults: a population-based cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-02 Gustavo G Nascimento, Huihua Li, Rahul Malhotra, Fábio R M Leite, Karen G Peres, Angelique Chan, Marco A Peres
Background Chewing disability is associated with impaired quality of life, potentially leading to depression and cognitive impairment. While the chewing-ability-cognition relationship has been explored, examining whether depression mediates this relationship remains unclear. We investigated the association between chewing disability and cognitive impairment development and a potential mediation via
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Entorhinal-based path integration selectively predicts midlife risk of Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2024-02-29 Coco Newton, Marianna Pope, Catarina Rua, Richard Henson, Zilong Ji, Neil Burgess, Christopher T. Rodgers, Matthias Stangl, Maria-Eleni Dounavi, Andrea Castegnaro, Ivan Koychev, Paresh Malhotra, Thomas Wolbers, Karen Ritchie, Craig W. Ritchie, John O'Brien, Li Su, Dennis Chan
Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)–based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD.
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Genetic diversity promotes resilience in a mouse model of Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-01 Neelakshi Soni, Lindsay A. Hohsfield, Kristine M. Tran, Shimako Kawauchi, Amber Walker, Dominic Javonillo, Jimmy Phan, Dina Matheos, Celia Da Cunha, Asli Uyar, Giedre Milinkeviciute, Angela Gomez‐Arboledas, Katelynn Tran, Catherine C. Kaczorowski, Marcelo A. Wood, Andrea J. Tenner, Frank M. LaFerla, Gregory W. Carter, Ali Mortazavi, Vivek Swarup, Grant R. MacGregor, Kim N. Green
INTRODUCTIONAlzheimer's disease (AD) is a neurodegenerative disorder with multifactorial etiology, including genetic factors that play a significant role in disease risk and resilience. However, the role of genetic diversity in preclinical AD studies has received limited attention.METHODSWe crossed five Collaborative Cross strains with 5xFAD C57BL/6J female mice to generate F1 mice with and without
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Analysis of agreement between measures of subjective cognitive impairment and probable dementia in the National Health and Aging Trends Study Alzheimers Dement. (IF 14.0) Pub Date : 2024-03-01 Linda C. Chyr, Jennifer L. Wolff, Julie M. Zissimopoulos, Emmanuel F. Drabo
BACKGROUNDSubjective cognitive impairment (SCI) measures in population‐based surveys offer potential for dementia surveillance, yet their validation against established dementia measures is lacking.METHODSWe assessed agreement between SCI and a validated probable dementia algorithm in a random one‐third sample (n = 1936) of participants in the 2012 National Health and Aging Trends Study (NHATS).RESULTSSCI