INTRODUCTIONRecent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans.METHODSThe present study used 17 years of data from a sample of 255 Black Americans to investigate the extent to which exposure to racial discrimination predicts subsequent changes in serum Alzheimer's Disease Research Center (ADRC) biomarkers: serum phosphorylated tau181(p‐tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP). We hypothesized that racial discrimination assessed during middle age would predict increases in these serum biomarkers as the participants aged into their 60s.RESULTSOur findings indicate that exposure to various forms of racial discrimination during a person's 40s and early 50s predicts an 11‐year increase in both serum p‐tau181 and NfL. Racial discrimination was not associated with subsequent levels of GFAP.DISCUSSIONThese findings suggest that racial discrimination in midlife may contribute to increased AD pathology and neurodegeneration later in life.Highlights A 17‐year longitudinal study of Black Americans. Assessments of change in serum p‐tau181, neurofilament light, and glial fibrillary acidic protein. Exposure to racial discrimination during middle age predicted increases in p‐tau181 and neurofilament light. Education was positively related to both p‐tau181 and exposure to racial discrimination.

中文翻译：

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中年时期的种族歧视预示着十年后血清磷酸化 tau 蛋白和神经丝轻链水平会更高：一项针对美国老年黑人的研究

引言 最近的证据表明，暴露于种族主义压力可能会增加美国黑人患痴呆症的风险。 方法本研究使用 255 名美国黑人样本的 17 年数据来调查暴露于种族歧视在多大程度上预测随后的血清变化阿尔茨海默病研究中心 (ADRC) 生物标志物：血清磷酸化 tau181 (p-tau181)、神经丝光 (NfL) 和胶质纤维酸性蛋白 (GFAP)。我们假设，在中年期间评估的种族歧视将预测随着参与者年龄增长到 60 多岁，这些血清生物标志物会增加。结果我们的研究结果表明，在一个人 40 多岁和 50 岁出头期间遭受各种形式的种族歧视，预示着这些血清生物标志物在 11 年内都会增加。血清 p-tau181 和 NfL。种族歧视与随后的 GFAP 水平无关。讨论这些发现表明，中年时期的种族歧视可能会导致晚年 AD 病理和神经退行性病变的增加。 对美国黑人进行了 17 年的纵向研究。 评估血清 p-tau181、神经丝光和胶质纤维酸性蛋白的变化。 中年时期遭受种族歧视预示着 p-tau181 和神经丝光的增加。 教育程度与 p-tau181 和种族歧视暴露呈正相关。