GeroScience ( IF 5.6 ) Pub Date : 2024-04-10 , DOI: 10.1007/s11357-024-01151-x Jordan N. Williamson , Shirley A. James , Sean P. Mullen , Bradley P. Sutton , Tracey Wszalek , Beni Mulyana , Peter Mukli , Andriy Yabluchanskiy , Michael Weiner , Paul Aisen , Ronald Petersen , Clifford R. Jack , William Jagust , John Q. Trojanowki , Arthur W. Toga , Laurel Beckett , Robert C. Green , Andrew J. Saykin , John C. Morris , Leslie M. Shaw , Enchi Liu , Tom Montine , Ronald G. Thomas , Michael Donohue , Sarah Walter , Devon Gessert , Tamie Sather , Gus Jiminez , Danielle Harvey , Matthew Bernstein , Nick Fox , Paul Thompson , Norbert Schuff , Charles DeCArli , Bret Borowski , Jeff Gunter , Matt Senjem , Prashanthi Vemuri , David Jones , Kejal Kantarci , Chad Ward , Robert A. Koeppe , Norm Foster , Eric M. Reiman , Kewei Chen , Chet Mathis , Susan Landau , Nigel J. Cairns , Erin Householder , Lisa Taylor Reinwald , Virginia Lee , Magdalena Korecka , Michal Figurski , Karen Crawford , Scott Neu , Tatiana M. Foroud , Steven Potkin , Li Shen , Faber Kelley , Sungeun Kim , Kwangsik Nho , Zaven Kachaturian , Richard Frank , Peter J. Snyder , Susan Molchan , Jeffrey Kaye , Joseph Quinn , Betty Lind , Raina Carter , Sara Dolen , Lon S. Schneider , Sonia Pawluczyk , Mauricio Beccera , Liberty Teodoro , Bryan M. Spann , James Brewer , Helen Vanderswag , Adam Fleisher , Judith L. Heidebrink , Joanne L. Lord , Ronald Petersen , Sara S. Mason , Colleen S. Albers , David Knopman , Kris Johnson , Rachelle S. Doody , Javier Villanueva Meyer , Munir Chowdhury , Susan Rountree , Mimi Dang , Yaakov Stern , Lawrence S. Honig , Karen L. Bell , Beau Ances , Maria Carroll , Sue Leon , Erin Householder , Mark A. Mintun , Stacy Schneider , Angela OliverNG , Randall Griffith , David Clark , David Geldmacher , John Brockington , Erik Roberson , Hillel Grossman , Effie Mitsis , Leyla deToledo-Morrell , Raj C. Shah , Ranjan Duara , Daniel Varon , Maria T. Greig , Peggy Roberts , Marilyn Albert , Chiadi Onyike , Daniel D’Agostino , Stephanie Kielb , James E. Galvin , Dana M. Pogorele , Brittany Cerbone , Christina A. Michel , Henry Rusinek , Mony J. de Leon , Lidia Glodzik , Susan De Santi , P. Murali Doraiswamy , Jeffrey R. Petrella , Terence Z. Wong , Steven E. Arnold , Jason H. Karlawish , David A. Wolk , Charles D. Smith , Greg Jicha , Peter Hardy , Partha Sinha , Elizabeth Oates , Gary Conrad , Oscar L. Lopez , MaryAnn Oakley , Donna M. Simpson , Anton P. Porsteinsson , Bonnie S. Goldstein , Kim Martin , Kelly M. Makino , M. Saleem Ismail , Connie Brand , Ruth A. Mulnard , Gaby Thai , Catherine Mc Adams Ortiz , Kyle Womack , Dana Mathews , Mary Quiceno , Ramon Diaz Arrastia , Richard King , Myron Weiner , Kristen Martin Cook , Michael DeVous , Allan I. Levey , James J. Lah , Janet S. Cellar , Jeffrey M. Burns , Heather S. Anderson , Russell H. Swerdlow , Liana Apostolova , Kathleen Tingus , Ellen Woo , Daniel H. S. Silverman , Po H. Lu , George Bartzokis , Neill R. Graff Radford , Francine Parfitt , Tracy Kendall , Heather Johnson , Martin R. Farlow , Ann Marie Hake , Brandy R. Matthews , Scott Herring , Cynthia Hunt , Christopher H. van Dyck , Richard E. Carson , Martha G. MacAvoy , Howard Chertkow , Howard Bergman , Chris Hosein , Sandra Black , Bojana Stefanovic , Curtis Caldwell , Ging Yuek Robin Hsiung , Howard Feldman , Benita Mudge , Michele Assaly Past , Andrew Kertesz , John Rogers , Dick Trost , Charles Bernick , Donna Munic , Diana Kerwin , Marek Marsel Mesulam , Kristine Lipowski , Chuang Kuo Wu , Nancy Johnson , Carl Sadowsky , Walter Martinez , Teresa Villena , Raymond Scott Turner , Kathleen Johnson , Brigid Reynolds , Reisa A. Sperling , Keith A. Johnson , Gad Marshall , Meghan Frey , Jerome Yesavage , Joy L. Taylor , Barton Lane , Allyson Rosen , Jared Tinklenberg , Marwan N. Sabbagh , Christine M. Belden , Sandra A. Jacobson , Sherye A. Sirrel , Neil Kowall , Ronald Killiany , Andrew E. Budson , Alexander Norbash , Patricia Lynn Johnson , Thomas O. Obisesan , Saba Wolday , Joanne Allard , Alan Lerner , Paula Ogrocki , Leon Hudson , Evan Fletcher , Owen Carmichael , John Olichney , Charles DeCarli , Smita Kittur , Michael Borrie , T. Y. Lee , Rob Bartha , Sterling Johnson , Sanjay Asthana , Cynthia M. Carlsson , Steven G. Potkin , Adrian Preda , Dana Nguyen , Pierre Tariot , Adam Fleisher , Stephanie Reeder , Vernice Bates , Horacio Capote , Michelle Rainka , Douglas W. Scharre , Maria Kataki , Anahita Adeli , Earl A. Zimmerman , Dzintra Celmins , Alice D. Brown , Godfrey D. Pearlson , Karen Blank , Karen Anderson , Robert B. Santulli , Tamar J. Kitzmiller , Eben S. Schwartz , Kaycee M. Sink , Jeff D. Williamson , Pradeep Garg , Franklin Watkins , Brian R. Ott , Henry Querfurth , Geoffrey Tremont , Stephen Salloway , Paul Malloy , Stephen Correia , Howard J. Rosen , Bruce L. Miller , Jacobo Mintzer , Kenneth Spicer , David Bachman , Elizabether Finger , Stephen Pasternak , Irina Rachinsky , John Rogers , Andrew Kertesz , Dick Drost , Nunzio Pomara , Raymundo Hernando , Antero Sarrael , Susan K. Schultz , Laura L. Boles Ponto , Hyungsub Shim , Karen Elizabeth Smith , Norman Relkin , Gloria Chaing , Lisa Raudin , Amanda Smith , Kristin Fargher , Balebail Ashok Raj , Yuan Yang ,
|
As of 2023, it is estimated that 6.7 million individuals in the United States live with Alzheimer’s disease (AD). Prior research indicates that AD disproportionality affects females; females have a greater incidence rate, perform worse on a variety of neuropsychological tasks, and have greater total brain atrophy. Recent research shows that hippocampal functional connectivity differs by sex and may be related to the observed sex differences in AD, and apolipoprotein E (ApoE) ε4 carriers have reduced hippocampal functional connectivity. The purpose of this study was to determine if the ApoE genotype plays a role in the observed sex differences in hippocampal functional connectivity in Alzheimer’s disease. The resting state fMRI and T2 MRI of individuals with AD (n = 30, female = 15) and cognitively normal individuals (n = 30, female = 15) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed using the functional connectivity toolbox (CONN). Our results demonstrated intrahippocampal functional connectivity differed between those without an ε4 allele and those with at least one ε4 allele in each group. Additionally, intrahippocampal functional connectivity differed only by sex when Alzheimer’s participants had at least one ε4 allele. These results improve our current understanding of the role of the interacting relationship between sex, ApoE genotype, and hippocampal function in AD. Understanding these biomarkers may aid in the development of sex-specific interventions for improved AD treatment.
中文翻译：
阿尔茨海默病中相互作用的遗传和功能连接生物标志物的性别差异
截至 2023 年，估计美国有 670 万人患有阿尔茨海默病 (AD)。先前的研究表明，AD 比例失调会影响女性；女性的发病率更高，在各种神经心理学任务上表现更差，并且总脑萎缩程度更高。最近的研究表明，海马功能连接因性别而异，可能与 AD 中观察到的性别差异有关，载脂蛋白 E (ApoE) ε4 携带者的海马功能连接降低。本研究的目的是确定 ApoE 基因型是否在阿尔茨海默病海马功能连接的性别差异中发挥作用。 使用功能连接工具箱分析了阿尔茨海默病神经影像计划 (ADNI) 的AD 患者（n = 30，女性 = 15）和认知正常个体（n = 30，女性 = 15）的静息态 fMRI 和 T2 MRI（康涅狄格州）。我们的结果表明，每组中没有 ε4 等位基因的人和至少有一个 ε4 等位基因的海马内功能连接存在差异。此外，当阿尔茨海默病参与者至少有一个 ε4 等位基因时，海马内功能连接仅因性别而异。这些结果提高了我们目前对性别、ApoE 基因型和海马功能之间相互作用关系在 AD 中的作用的理解。了解这些生物标志物可能有助于开发针对改善 AD 治疗的针对性别的干预措施。
京公网安备 11010802027423号