Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment,Alzheimer's & Dementia

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Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2024-04-18 , DOI: 10.1002/alz.13817
Jie Wang ₁ , Qi Huang ₁ , Kun He ₁ , Junpeng Li ₁ , Tengfei Guo ₂ , Yang Yang ₃ , Zengping Lin ₄ , Songye Li ₅ , Greet Vanderlinden ₆ , Yiyun Huang ₅ , Koen Van Laere ₆ , Yihui Guan ₁ , Qihao Guo ₇ , Ruiqing Ni _{8,

9} , Binying Li ₁₀ , Fang Xie _{1,

11}

Affiliation

Department of Nuclear Medicine & PET Center Huashan Hospital, Fudan University Shanghai China
Institute of Biomedical Engineering, Shenzhen Bay Laboratory Shenzhen China
Beijing United Imaging Research Institute of Intelligent Imaging Beijing China
Central Research Institute, United Imaging Healthcare Group Co., Ltd Shanghai China
Department of Radiology and Biomedical Imaging PET Center Yale University School of Medicine New Haven Connecticut USA
Department of Imaging and Pathology Nuclear Medicine and Molecular Imaging, KU Leuven Leuven Belgium
Department of Gerontology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China
Institute for Biomedical Engineering, University of Zurich & ETH Zurich Zurich Switzerland
Institute for Regenerative Medicine University of Zurich Zurich Switzerland
Department of Neurology and Institute of Neurology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University Shanghai China

Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the pathophysiological mechanism of Alzheimer's disease (AD).

中文翻译：

SV2A PET 测定的突触前密度与突触后代谢型谷氨酸受体 5 的可用性密切相关，并且与早期认知障碍中的淀粉样蛋白病理无关

代谢型谷氨酸受体 5 (mGluR5) 参与调节大脑综合功能和突触传递。异常的 mGluR5 信号传导和相关的突触衰竭在阿尔茨海默病 (AD) 的病理生理机制中发挥着关键作用。

更新日期：2024-04-18

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