OBJECTIVES To determine the risk of inflammatory bowel disease (IBD) in patients with celiac disease (CeD) (and vice versa) compared to general-population comparators. METHODS Using Swedish histopathology and healthcare register data, we identified 48,551 patients with CeD and 83,529 with IBD diagnosed in 1969-2016. Each patient was compared to age- and sex-matched general-population comparators (CeD:

INTRODUCTION A family history of gastric cancer (GC) is a well-known risk factor for GC. However, the association between family history of GC and the risk of GC and gastric adenoma according to the affected family members is unclear. METHODS We analyzed the data of participants aged ≥40 years who underwent national GC screening between 2013 and 2014. Participants with and without a family history

BACKGROUND AIMS Fundic Gland Polyps (FGPs) are commonly found in familial adenomatous polyposis (FAP) patients and are considered benign. Biopsies are not routinely done, and conventional forceps may be time-consuming and/or yield non-representative histology. The purpose of this study was to evaluate the role of a novel endoscopic polypectomy surveillance (EPS), a large volume cold-snare polypectomy

When the only biologics were anti TNF agents, it was not hard to treat our sick Crohn's patients. Now with multiple mechanisms of action the therapeutic landscape is more broad but can be confusing. Trying to compare agents is difficult because head to head trials are lacking. Comparative effectiveness methodology allows for indirect comparisons of agents based on the outcome of interest. When deciding

BACKGROUND Cannabidiol (CBD), a CBR2 agonist with limited psychic effects, antagonizes CB1/CB2 receptors. Allelic variation CNR1 (gene for CBR1) rs806378 and FAAH rs324420 were associated with altered gut motility and sensation. This study aimed to compare pharmacodynamics and clinical effects of 4-week treatment with pharmaceutical grade CBD vs. placebo and also to assess interactions of FAAH and

It has been over 50 years since the Stonewall Inn Riots in June 1969, a seminal event for the lesbian, gay, bisexual, transgender, queer, intersex, and other sexual and gender-diverse minorities (LGBTQI+, or lesbian, gay, bisexual, transgender, queer, intersex, and everyone else) rights movement. However, sexual and gender minority (SGM) individuals still face discrimination and harassment due to their

INTRODUCTION Antimicrobial resistance among Helicobacter pylori (H. pylori) strains has been rising globally, leading to declining eradication rates. We performed a systematic review and meta-analysis of the resistance patterns of H. pylori strains in the United States between 2011 and 2021. METHODS Ovid MEDLINE, Embase, CINAHL, and Cochrane CENTRAL databases were searched for manuscripts and conference

There has been a dramatic increase in clinical studies examining the relationship between disorders of gut-brain interactions and symptoms evoked by food ingestion in the upper and lower gastrointestinal tract, but study design is challenging to verify valid endpoints. Consequently, mechanistic studies demonstrating biological relevance, biomarkers and novel therapeutic targets are greatly needed.

OBJECTIVES We investigated cardiovascular risk due to proton pump inhibitor (PPI) treatment using a self-controlled case series (SCCS) study design, a type of case-only design and an approach to overcome between-person confounding in which individuals act as their own control. METHODS We conducted an SCCS study using the National Health Insurance Service-Health Screening cohort in Korea (2002-2015)

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant disorders associated with an increased risk of benign and malignant intestinal and extraintestinal tumors. They include Peutz-Jeghers syndrome, juvenile polyposis syndrome, the PTEN hamartoma tumor syndrome (including Cowden's syndrome and Bannayan-Riley-Ruvalcaba syndrome), and hereditary mixed polyposis syndrome.

INTRODUCTION The correlation between clinical and molecular treatment response thresholds in eosinophilic esophagitis (EoE) is not well understood. METHODS We evaluated post-treatment EoE diagnostic panel (EDP) gene expression profiles across histologic and endoscopic (EREFS) thresholds in a prospective adult EoE cohort. RESULTS We observed a strong inverse correlation between post-treatment gene score

OBJECTIVES Despite the high prevalence of pediatric obesity, its impact on Crohn's disease (CD) and ulcerative colitis (UC) activity remains poorly characterized. The aim of this study was to evaluate disease-related outcomes in overweight and obese children with CD and UC. METHODS We conducted a retrospective cohort study utilizing the ImproveCareNow Network (ICN), a multicenter registry of children

INTRODUCTION There are limited data correlating symptoms with reflux episodes during pH studies after POEM. METHODS Consecutive patients who underwent POEM followed ≥6 months later by 48-hour ambulatory wireless pH testing off antisecretory therapy were identified. Reflux symptom association (RSA) was defined as SAP >95%. RESULTS The most frequent of symptoms of heartburn (47.2%), cough (45.1%) and

BACKGROUND Optimizing complete resection during colonoscopy is important as residual neoplastic tissue may play a role in interval cancers. The United States Multi-Society Task Force recommends diminutive (<5mm) and small (6-9mm) polyps be removed by cold snare polypectomy (CSP). However, evidence is less clear whether CSP retains significant advantage over cold forceps polypectomy (CFP) for polyps

INTRODUCTION Evidence about specific carbohydrate diet (SCD) for inflammatory bowel disease (IBD) is limited. We conducted 54 single-subject, double-crossover N-of-1 trials comparing SCD with a modified SCD (MSCD) and comparing each with the participant's baseline, usual diet (UD). METHODS Across 19 sites, we recruited patients aged 7-18 years with IBD and active inflammation. Following a 2-week baseline

BACKGROUND AND AIMS We compared the efficacy of adalimumab, infliximab, ustekinumab, and vedolizumab on the ability to achieve endoscopic healing (EH) after one-year of therapy in moderate-severe Crohn's disease (CD). METHODS Pooled analysis of patient-level data from 299 patients with CD from four clinical trials. Proportions of patients treated with each biologic were compared for achieving one-year

INTRODUCTION Though the association of absent or attenuated "call to stool" with constipation is well-recognized, no studies have systematically evaluated the perception of urge to defecate in a well-defined cohort of patients with chronic constipation (CC). METHODS Prospective study of 43 healthy adult women and 140 consecutive adult women attending a tertiary center for investigation of CC. All participants

BACKGROUND AND AIMS The use of ustekinumab and vedolizumab as second line therapy in Crohn's disease patients in which tumour necrosis factor alpha inhibitors (TNFi) failed is still debated. The aim of the study was to compare, in a large multicentre observational retrospective cohort, the effectiveness of ustekinumab and vedolizumab as second line therapy as assessed by clinical and objective outcomes

Gluten-free (GF) foods are generally costlier than their gluten-containing counterparts. We conducted an anonymous electronic survey to assess food insecurity in households with a child on a prescribed GF diet and how this relates to GF diet adherence during the COVID-19 pandemic. The proportion of households who screened positive using the Hunger Vital Sign was similar to national rates (19%-24%)

Food ingestion is a major symptom trigger in functional esophageal and gastroduodenal disorders and gastroparesis. This review summarizes current knowledge and identifies areas of research on the role of food factors and the opportunities for dietary intervention in these disorders. While many patients experiencing functional esophageal and gastroduodenal disorders identify specific food items as symptom

INTRODUCTION Outcomes and safety of budesonide maintenance therapy in microscopic colitis (MC) are not well known. METHODS Adult residents of Olmsted County, Minnesota diagnosed with MC (2002-2019) and treated with budesonide were identified using the Rochester Epidemiology Project. Response was assessed at 12 +/- 4 weeks after initiation of therapy and defined as complete (resolution of diarrhea)

Eosinophilic esophagitis (EoE) is a chronic, progressive, type 2 inflammatory disease of increasing prevalence, characterized by symptoms of dysphagia and reduced quality of life. A dysregulated type 2 immune response to food and aeroallergen leads to barrier dysfunction, chronic esophageal inflammation, remodeling, and fibrosis. Patients with EoE have impaired quality of life due to dysphagia and

Consistent with previous cross-sectional studies, in the Southern Community Cohort Study (SCCS), the largest cohort for Black Americans conducted in a predominantly low-income population with 81,694 participants, we found that moderate alcohol drinking was associated with a significantly increased risk of mortality due to liver disease in Black Americans (HR=2.06; 95%CI: 1.08, 3.94), but not in White

Dietary factors may play an important role in the generation of symptoms in children with disorders of gut-brain interaction (DGBIs). Although dietary modification may provide successful treatment, there is a relative paucity of controlled trials that have shown the effectiveness of dietary interventions. This study is a narrative review that explores the existing literature on food and pediatric DGBIs

INTRODUCTION Muscle cramps are common among persons with cirrhosis and associated with poor health-related quality of life. Treatment options are limited. We sought to determine whether pickle juice can improve muscle cramp severity. METHODS We enrolled 82 patients with cirrhosis and a history of >4 muscle cramps in the previous month from December 2020 to December 2021. Patients were randomized 1:1