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PD1 × VEGF blocking bispecifics for cancer draw big backing Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-10
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FDA approves first-in-class TRPM8 ion channel agonist for dry eye disease Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-10
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FDA approves a c-MET-targeted ADC for lung cancer Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-10
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Cryptic antigens flag cancer cells to T cell therapy Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-09
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Targeting protein disorder: the next hurdle in drug discovery Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-09 Tamas Lazar, Acadia Connor, Charles F. DeLisle, Virginia Burger, Peter Tompa
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Delivering regulatory impact from consortium-based projects Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-09 Martha A. Brumfield, Graham C. Higson, Cécile Ollivier, Nathalie Seigneuret
Multiple consortia have been established in the past two decades with the aim of tackling roadblocks in the development of medical products, often by developing new tools to support decision making by regulatory agencies. Here, we highlight lessons learned from these efforts that could help maximize the regulatory impact of consortium-based projects.
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In utero ASO therapy for spinal muscular atrophy Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-05
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The landscape for radioligand therapies in oncology Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-03
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Lowering pathological α-synuclein Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
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Prolonging the antidepressant effects of ketamine Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
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Towards a universal snake antivenom Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
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Blocking a cell surface protein beats AML Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
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The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02 Arielle Elkrief, Reilly Pidgeon, Saman Maleki Vareki, Meriem Messaoudene, Bastien Castagner, Bertrand Routy
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A new drug target for NRAS(Q61) mutant-expressing cancers Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-29
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Author Correction: GLP-1-based therapies for diabetes, obesity and beyond Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-28 Daniel J. Drucker
Correction to: Nature Reviews Drug Discovery https://doi.org/10.1038/s41573-025-01183-8, published online 25 April 2025.
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Triggering ferroptosis in drug-tolerant cancer cells Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-27
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Innovative Medicines Initiative public–private partnerships to enhance translational safety Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-22 Salah-Dine Chibout, Dominique Brees, Magda Chlebus, Philippe Detilleux, Loic Laplanche, Jonathan Moggs, Shashi K. Ramaiah, Jacques Richard, Gunnar Schütz, Nathalie Seigneuret, Thomas Steger-Hartmann, Elisabetta Vaudano
Innovative Medicines Initiative projects focused on translational safety have developed a range of tools to improve preclinical assessments of potential drug toxicities, and demonstrated the value of integrating data from multiple companies.
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Amylin takes another shot at the obesity prize Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-20
Drug developers are re-advancing amylin analogues for obesity, two decades since the FDA approved the first of these hormone mimetics for diabetes.
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Targeting neutrophils for cancer therapy Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-15 Jeff W. Kwak, A. McGarry Houghton
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Is the FDA’s plan to phase out animal toxicity testing realistic? Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-15
Lorna Ewart, Chief Scientific Officer at Emulate, discusses the new opportunities and remaining challenges facing organs on chips.
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FDA approves a rare novel–novel oncology combination that pairs a first-in-class FAK inhibitor with a MEK–RAF glue inhibitor Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-13
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The race to reset autoimmune diseases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-12
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Hinge modifier approach opens door to drugging HECT E3 ligases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-09
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A liver-directed route to reverse allergies Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-08
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FDA approves J&J’s FcRN blocker for generalized myasthenia gravis Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-07
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FDA approves cell-sheet-based gene therapy for severe skin disease Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-07
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Application of new approach methodologies for nonclinical safety assessment of drug candidates Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-02 Mario Beilmann, Karissa Adkins, Harrie C. M. Boonen, Philip Hewitt, Wenyue Hu, Robert Mader, Susanne Moore, Payal Rana, Thomas Steger-Hartmann, Remi Villenave, Terry van Vleet
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Ramping up mitochondrial DNA replication Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-02
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Targeting RNA structure to treat prostate cancer Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-02
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Lasso peptide targets drug-resistant bacteria Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-02
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TIM-3 regulates microglial function Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-02
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Understanding LAG3 immune checkpoint function Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-05-02
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GLP-1-based therapies for diabetes, obesity and beyond Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-25 Daniel J. Drucker
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New antifungal tackles drug-resistant infections Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-24
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The impact of accelerated drug marketing registration procedures on the review and approval of new drugs in China Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-23
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Enzymes in secondary pharmacology screening panels: is there room for improvement? Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-22 Monika Maciag, Vardan T. Karamyan
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Shaping secondary pharmacology panels of the future: evolving target selection criteria for safety panels Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-22 Friedemann Schmidt, Richard J. Brennan, Steve Jenkinson, Jean-Pierre Valentin
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The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-17 Carolina M. Polonio, Kimberly A. McHale, David H. Sherr, David Rubenstein, Francisco J. Quintana
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Back to the drawing board for anhedonia drugs Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-16
Johnson & Johnson has discontinued development of aticaprant for depression with anhedonia, a blow to hopes for drugs for ‘domains’ of psychiatric disorders.
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Back to therapeutic modality basics Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-16
Andy Plump, Takeda’s head of R&D, discusses the company’s evolving pipeline, therapeutic modalities, and upheaval in biotech, the NIH and the FDA.
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FDA new drug approvals in Q1 2025 Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-14
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Biomarker-guided decision making in clinical drug development for neurodegenerative disorders Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-04 Jeffrey L. Cummings, Charlotte E. Teunissen, Brian K. Fiske, Isabelle Le Ber, Kristin R. Wildsmith, Michael Schöll, Billy Dunn, Philip Scheltens
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Analysis of China-to-West pharmaceutical licensing deals in 2024 Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-04
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Novel drug targets in 2024 Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-04
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Trends in the drug target landscape for autoimmune diseases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-03
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FDA approves siRNA drug for haemophilia prophylaxis Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-02
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Oral IL-23-blocking peptide racks up phase III wins in inflammatory disease Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-01
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Publisher Correction: Fibrosis: cross-organ biology and pathways to development of innovative drugs Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-31 Florian Rieder, Laura E. Nagy, Toby M. Maher, Jörg H. W. Distler, Rafael Kramann, Boris Hinz, Marco Prunotto
Correction to: Nature Reviews Drug Discovery https://doi.org/10.1038/s41573-025-01158-9, published online 18 March 2025.
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New antibiotic for urinary tract infections nabs FDA approval Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-31
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Non-incretin peptide curbs appetite Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-28
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Two routes to tamp down microglia in traumatic brain injury Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-26
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Towards an oral norovirus vaccine Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-25
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Small-molecule hypoxia therapy Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-25
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Identifying novel antibiotic targets Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-25
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Blocking ceramide signalling alleviates atherosclerosis Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-25
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Cannabinoid targets hidden pocket for safer pain relief Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-24
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New approach methodologies: EU regulatory horizons Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-24 Mariana Edwards, Oriane Blanquie, Orla Moriarty, Sonja Beken, Falk Ehmann
New approach methodologies (NAMs) have the potential to progressively transform medicines development by reducing reliance on animal testing while increasing the relevance of nonclinical data to patients. However, achieving regulatory acceptance of NAMs demands enhanced collaboration, clear guidance and continuous, science-based adaptation of the regulatory environment to accommodate emerging innovation
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Insights into new approach methodology innovation: an EMA perspective Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-24
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Life science ecosystems in Asia: biomedical innovation trends over the past decade Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-21
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A new target for cancer cachexia Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-03-20
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