Objective Crohn's disease (CD) patients included in the TAILORIX trial started infliximab in combination with an immunosuppressant for one year. The aim of the present study was to determine the long-term disease course beyond the study period. Design We compared the outcomes of patients that did or did not reach the primary endpoint of the TAILORIX trial, defined as sustained corticosteroid-free clinical

BACKGROUND AND AIMS The use of forceps for removal of non-diminutive polyps is associated with incomplete resection compared to snare polypectomy. However, few studies have characterized the frequency of forceps polypectomy for non-diminutive polyps or identified strategies to improve this practice. To address this gap, we estimated prevalence and predictors of forceps polypectomy in clinical practice

Background & Aims Patients with decompensated liver disease have been categorized by disease severity. This analysis sought to classify patients with end-stage liver disease (ESLD) based on symptoms rather than disease state and to identify distinct severity classes of physical and psychological symptoms. Methods Patients with a Sodium Model for ESLD (MELD-Na) score >15 were recruited from liver clinics

Background & Aims In patients with celiac disease, gluten triggers an immune reaction that damages small intestinal villi and may increase long-term risk of gastrointestinal cancer. However, the health impacts of gluten in the general population are understudied. We aimed to examine the association between gluten intake and risk of digestive system cancers among individuals without celiac disease.

Background Eosinophilic esophagitis (EoE) has a strong male predominance that appears at least partially due to genetic susceptibility. However, data regarding sex-related differences in patients with EoE are scarce. Methods We analyzed prospectively collected data from adults enrolled into the Swiss EoE cohort study (SEECS). Patients with and without dilation in the past 12 months completed patient-reported

Background & Aims Data regarding fecal calprotectin (FC), commonly used for non-invasive monitoring in inflammatory bowel diseases (IBD), are scarce in patients with Ileal pouch-anal anastomosis (IPAA). We aimed to assess the association between FC levels and pouch inflammation in patients with ulcerative colitis who underwent IPAA. Methods A cross-sectional study of adults with ulcerative colitis

Background and Aims Integrated IBD care is effective but not routinely implemented. Validated methods that simultaneously address mind and body targets such as resilience may improve access and outcomes. We describe the development and implementation of the GRITTTM Method and its impact on resilience, health care resource utilization (HCRU) and opioid use in IBD. Methods Consecutive patients from an

Background Globally, nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. We assessed clinical presentation and patient-reported outcomes (PROs) among NAFLD patients from different countries. Methods Clinical, laboratory and PRO data (CLDQ-NASH, FACIT-F, WPAI) were collected from NAFLD patients seen in real-world practices and enrolled in the Global NAFLD/NASH Registry

Background An association of eosinophilic esophagitis (EoE) with esophageal dysmotility has been described, however the related mechanism remains unclear. We aimed to evaluate clinical and physiologic characteristics, including esophageal distensibility, associated with secondary peristalsis in patients with EoE. Methods 199 consecutive adult patients with EoE (ages 18-78, 32% female) that completed

Background Non-alcoholic fatty liver disease (NAFLD) is associated with sugar-sweetened beverage (SSB) consumption in cross-sectional studies. In a prospective cohort, we examined the association of beverage consumption (SSB and diet soda) with incident NAFLD and changes in hepatic fat in the Framingham Heart Study (FHS). Methods We conducted a prospective observational study of participants from the

The burden of cirrhosis may be increasing, especially among the elderly. A recent updated definition of cirrhosis has a >90% positive predictive value for identifying cirrhosis and cirrhosis-related complications.1 We hypothesized that cirrhosis-related mortality is underestimated, and that the elderly are disproportionally impacted. In this study, we aimed to examine trends in liver-related mortality

Background & Aims Globally, 25% of people have Non-Alcoholic Fatty Liver Disease (NAFLD) and currently there are no approved pharmacological treatments for NAFLD. With a slow disease progression, long-term impact of pharmacological treatments can only be assessed by complementing emerging clinical trial evidence by data from other sources in disease progression modelling. Although this modelling is

Description Delayed gastric emptying on objective testing defines gastroparesis, but symptoms overlap with functional dyspepsia, and do not correlate well with gastric emptying delay. This review outlines a strategy for defining, diagnosing and managing refractory gastroparesis. Methods The Best Practice Advice statements presented here were developed from review of existing literature combined with

Background and aim Despite extensive Barrett’s esophagus (BE) screening efforts, most patients with esophageal adenocarcinoma (EAC) present de novo. It is unclear how much of this problem is due to insensitivity or poor applications of current screening guidelines. We aimed to evaluate the sensitivity of guidelines by determining the proportion of prevalent EAC cases that meet the American College

Obesity-related chronic inflammation contributes to nonalcoholic fatty liver disease (NAFLD) progression in obese patients (body mass index [BMI] >30 kg/m2).1 The early detection of inflammation with noninvasive imaging technology may help identify individuals with a high risk of developing NAFLD.

Background & Aims The natural course of gastric mild-moderate dysplasia in a country with high incidence of gastric cancer (GC) is relatively unknown. We aimed to determine the long-term cumulative incidence of and risk factors for advanced neoplasia in patients with gastric dysplasia. Methods This was a single center observational study including all consecutive patients diagnosed with gastric mild-moderate

Background & Aims The potential effectiveness of gut-directed hypnotherapy (HT) is unknown for pediatric chronic nausea. This randomized controlled trial compared HT with standard medical treatment (SMT). Methods Hundred children (8–18 years) with chronic nausea and fulfilling functional nausea (FN) or functional dyspepsia (FD) criteria were randomly allocated (1:1) to HT or SMT, with a 3-month intervention

Background & Aims Transplant-ineligible patients with advanced liver disease rarely receive timely advance care planning (ACP). Tools are needed to educate these patients about medical interventions available at the end of life to promote ACP. Methods This single-site pilot randomized controlled trial assessed the feasibility, acceptability, and preliminary efficacy of an ACP video decision support

Background and Aims There are few data assessing disease progression in eosinophilic esophagitis (EoE) after diagnosis. We aimed to determine outcomes and assess for progression of fibrosis in EoE patients with a gap in their regular care. Methods In this retrospective cohort study of newly diagnosed EoE patients, a “gap” in care was defined as ≥2 years without medical contact for EoE. For inclusion

Background and aims COVID-19 pandemic lockdown and restrictions had significant disruption to patient care. We aimed to evaluate the impact of COVID-19 restrictions on hospitalizations of patients with alcoholic and non-alcoholic cirrhosis as well as alcoholic hepatitis (AH) in Alberta, Canada. Methods We used validated international clinical classification (ICD-9 and ICD-10) coding algorithms to identify

Background & Aims Portal hypertension (PH) is the strongest predictor of hepatic decompensation and death in patients with cirrhosis. However, its discriminatory accuracy in patients with non-alcoholic fatty liver disease (NAFLD) has been challenged as hepatic vein catheterization may not reflect the real portal vein pressure as accurately as in patients with other etiologies. We aimed to evaluate

Background and Aims Prolonged colon transit times may increase contact time between potential carcinogens in the stool and the colonic mucosa. Nonetheless, previous studies have yielded conflicting results connecting chronic constipation with risk of CRC. We examined the association between chronic constipation and later CRC. Methods In this nationwide case-control study, we identified 41,299 CRC cases

The first coronavirus disease 2019 (COVID-19) pandemic surge harshly impacted the medically underserved populations of the urbanized northeastern United States. Severe acute respiratory syndrome coronavirus 2 virions infect the gastrointestinal (GI) tract, and GI symptoms are common during acute infection.1 Post-COVID syndromes increasingly are recognized as important public health considerations.2

Background and Aims Several endoscopic methods have been proposed for treatment of large biliary stones. We assessed the comparative efficacy of these treatments through a network meta-analysis. Methods 19 randomized controlled trials (2752 patients) comparing different treatments for management of large bile stones (>10 mm) (endoscopic sphincterotomy, balloon sphincteroplasty, sphincterotomy followed

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide.1,2 It is believed that about one fourth of the world population may have NAFLD.3 The Global Burden of Disease data suggest that NAFLD and nonalcoholic steatohepatitis (NASH) are the main drivers of liver disease burden in most regions of the world, including that of hepatocellular carcinoma

Chronic opioid use is associated with adverse effects on the gastrointestinal (GI) tract and increased morbidity.1-3 Despite efforts to de-escalate opioid use, 10% of outpatient GI visits are associated with an opioid prescription.4 Although we previously described declining opioid prescriptions to Medicare patients by most gastroenterologists,5 opioid prescriptions for GI conditions have increased

Background & Aims Missed or inappropriate referrals of potential candidates for liver transplantation (LT) are common and traditional referral methods (tRs) do not allow for efficient triage. We investigated the effects on these issues of a website developed for electronic oupatient referral to LT (eRW-LT) Methods We prospectively collected data on all consecutive outpatient referrals to two Italian