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KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-12 Gyuyeong Rah, Hwayeon Cha, Joohee Kim, Jieun Song, Hyunho Kim, Yun Kyu Oh, Curie Ahn, Minyong Kang, Jongmin Kim, Kyung Hyun Yoo, Min Jung Kim, Hyuk Wan Ko, Je Yeong Ko, Jong Hoon Park
Background Ciliogenesis-associated kinase 1 (CILK1) is a ciliary gene that localizes in primary cilia and regulates ciliary transport. Mutations in CILK1 cause various ciliopathies. However, the pathogenesis of CILK1-deficient kidney disease is unknown.Methods To examine whether CILK1 deficiency causes PKD accompanied by abnormal cilia, we generated mice with deletion of Cilk1 in cells of the renal
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Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins Leading to Secondary Hyperparathyroidism J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-12 Alia Hassan, Yael E. Pollak, Rachel Kilav-Levin, Justin Silver, Nir London, Morris Nechama, Iddo Z. Ben-Dov, Tally Naveh-Many
Background Secondary hyperparathyroidism (SHP) is a common complication of CKD that increases morbidity and mortality. In experimental SHP, increased parathyroid hormone (PTH) expression is due to enhanced PTH mRNA stability, mediated by changes in its interaction with stabilizing AUF1 and destabilizing KSRP. The isomerase Pin1 leads to KSRP dephosphorylation, but in SHP parathyroid Pin1 activity is
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Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Mariavittoria D’Acierno, Roberta Resaz, Anna Iervolino, Rikke Nielsen, Donato Sardella, Sabrina Siccardi, Vincenzo Costanzo, Luciano D’Apolito, Yoko Suzumoto, Daniela Segalerba, Simonetta Astigiano, Alessandra F. Perna, Giovambattista Capasso, Alessandra Eva, Francesco Trepiccione
Background Mutations in SLC37A4, which encodes the intracellular glucose transporter G6PT, cause the rare glycogen storage disease type 1b (GSD1b). A long-term consequence of GSD1b is kidney failure, which requires KRT. The main protein markers of proximal tubule function, including NaPi2A, NHE3, SGLT2, GLUT2, and AQP1, are downregulated as part of the disease phenotype.Methods We utilized an inducible
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Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Lin Dang, Xinyi Cao, Tianye Zhang, Yongzhan Sun, Shanshan Tian, Tianyu Gong, Hui Xiong, Peipei Cao, Yuhao Li, Shengqiang Yu, Li Yang, Lirong Zhang, Tong Liu, Kai Zhang, Jing Liang, Yupeng Chen
Background Emerging evidence indicates that epigenetic modulation of gene expression plays a key role in the progression of autosomal dominant polycystic kidney disease (ADPKD). However, the molecular basis for how the altered epigenome modulates transcriptional responses, and thereby disease progression in ADPKD, remains largely unknown.Methods Kidneys from control and ADPKD mice were examined for
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Description and Outcomes of an Innovative Concurrent Hospice-Dialysis Program J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Natalie C. Ernecoff, Alexandra E. Bursic, Erica M. Motter, Keith Lagnese, Robert Taylor, Jane O. Schell
Background Compared with the general Medicare population, patients with ESKD have worse quality metrics for end-of-life care, including a higher percentage experiencing hospitalizations and in-hospital deaths and a lower percentage referred to hospice. We developed a Concurrent Hospice and Dialysis Program in which patients may receive palliative dialysis alongside hospice services. The Program aims
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Prognostic Implications of a Morphometric Evaluation for Chronic Changes on All Diagnostic Native Kidney Biopsies J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Aleksandar Denic, Marija Bogojevic, Aidan F. Mullan, Moldovan Sabov, Muhammad S. Asghar, Sanjeev Sethi, Maxwell L. Smith, Fernando C. Fervenza, Richard J. Glassock, Musab S. Hommos, Andrew D. Rule
Visual Abstract
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Authors' Reply: Anti-Hinge Antibodies Are Likely to Be of Minor Importance. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Mårten Segelmark,Christian Kjellman
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Endopeptidase Therapy for Anti-Glomerular Basement Membrane Disease: Beware of Anti-Hinge Antibodies! J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Dorin-Bogdan Borza,Pallavi Manral
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Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-04 Martin Gritter, Rosa D. Wouda, Stanley M.H. Yeung, Michiel L.A. Wieërs, Frank Geurts, Maria A.J. de Ridder, Christian R.B. Ramakers, Liffert Vogt, Martin H. de Borst, Joris I. Rotmans, Ewout J. Hoorn
Background Observational studies suggest that adequate dietary potassium intake (90–120 mmol/day) may be renoprotective, but the effects of increasing dietary potassium and the risk of hyperkalemia are unknown.Methods This is a prespecified analysis of the run-in phase of a clinical trial in which 191 patients (age 68±11 years, 74% males, 86% European ancestry, eGFR 31±9 ml/min per 1.73 m2, 83% renin-angiotensin
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Searching for the Risk-Benefit Profile of Higher Potassium Intake in CKD: Primum Non Nocere. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-04 Murilo Guedes,Roberto Pecoits-Filho
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Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Keri A. Drake, Christopher Chaney, Mohita Patel, Amrita Das, Julia Bittencourt, Martin Cohn, Thomas J. Carroll
Background The embryonic renal stroma consists of multiple molecularly distinct cell subpopulations, the functional significance of which is largely unknown. Previous work has demonstrated that the transcription factors YAP and TAZ play roles in the development and morphogenesis of the nephrons, collecting ducts, and nephron progenitor cells.Methods In embryonic mouse kidneys, we identified a subpopulation
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Emerging Insights into Glomerular Vascular Pole and Microcirculation J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Michael S. Goligorsky
The glomerular vascular pole is the gate for the afferent and efferent arterioles and mesangial cells and a frequent location of peripolar cells with an unclear function. It has been studied in definitive detail for >30 years, and functionally interrogated in the context of signal transduction from the macula densa to the mesangial cells and afferent arteriolar smooth muscle cells from 10 to 20 years
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Early Molecular Events Mediating Loss of Aquaporin-2 during Ureteral Obstruction in Rat J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Chih-Chien Sung, Brian Poll, Shih-Hua Lin, Adrian Murillo-de-Ozores, Chung-Lin Chou, Lihe Chen, Chin-Rang Yang, Min-Hsiu Chen, Yu-Juei Hsu, Mark Knepper
Background: Ureteral obstruction is marked by disappearance of the vasopressin-dependent water channel aquaporin-2 (AQP2) in the renal collecting duct and polyuria upon reversal. Most studies of unilateral ureteral obstruction (UUO) models have examined late time points, obscuring the early signals that trigger loss of AQP2. Methods: We performed RNA-Seq on microdissected rat cortical collecting ducts
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Ensuring Equitable Access to Dialysis: The Medicare Secondary Payer Act in Marietta Memorial Hospital Employee Health Benefit Plan v. DaVita, Inc. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-03 George Maliha,Joel D Glickman,Matthew S McCoy
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Authors' Reply: Understanding the Multiple Roles of Extracellular Histones in Mediating Endothelial Dysfunction. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-03 Lara Zafrani,Marine Arnaud,Nuala Mooney
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Understanding the Multiple Roles of Extracellular Histones in Mediating Endothelial Dysfunction. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-03 Tinghang Yang,Yupei Li,Baihai Su
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The Potential for Pragmatic Trials to Reduce Racial and Ethnic Disparities in Kidney Disease. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-03 Laura M Dember
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The Advancing American Kidney Health Initiative: Do Not Let 80% Distract Us from the Fact that We Can Do Better. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Mallika L Mendu,Scott D Bieber,Suzanne G Watnick,Daniel E Weiner
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Decorating Histones in Polycystic Kidney Disease. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Harini Ramalingam,Vishal Patel
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Response to "The Advancing American Kidney Health Initiative: The Challenge of Overcoming the Status Quo" and "The Advancing American Kidney Health Initiative: Do Not Let 80% Distract Us from the Fact that We Can Do Better". J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Robert R Quinn,Ngan N Lam,Pietro Ravani,Matthew J Oliver,Peter G Blake,Marcello Tonelli
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The Case for Prioritizing Diversity in the Transplantation Workforce to Advance Kidney Health Equity. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Thomas Butler,Lee Cummings,Tanjala Purnell
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The Advancing American Kidney Health Initiative: The Challenge of Overcoming the Status Quo. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Paul T Conway,Nieltje Gedney,Shuvo Roy,William H Fissell
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Authors' Reply: Serum Protein-induced Tubular Injury. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Kevin Lidberg,Jonathan Himmelfarb,Edward Kelly,Shreeram Akilesh
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Polycystin-2 in the Endoplasmic Reticulum: Bending Ideas about the Role of the Cilium. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Michael J Caplan
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Identifying Antigen-Specific T Cells in ANCA-Associated Vasculitis: A Glimpse of the Future? J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Lani Shochet,A Richard Kitching
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A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients Five-Tier Rating System J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Kaicheng Wang, Yanhong Deng, Darren Stewart, Richard N. Formica
Background Performance of kidney transplant programs in the United States is monitored and publicly reported by the Scientific Registry of Transplant Recipients (SRTR). With relatively few allograft failure events per program and increasing homogeneity in program performance, quantifying meaningful differences in program competency based only on 1-year survival rates is challenging. Methods We explored
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The Relationship between Cerebrovascular Reactivity and Cerebral Oxygenation during Hemodialysis J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Wesley T. Richerson, Brian D. Schmit, Dawn F. Wolfgram
Background Patients with kidney failure treated with hemodialysis (HD) may be at risk for cerebral hypoperfusion due to HD-induced BP decline in the setting of impaired cerebral autoregulation. Cerebrovascular reactivity (CVR), the cerebrovascular response to vasoactive stimuli, may be a useful indicator of cerebral autoregulation in the HD population and identify those at risk for cerebral hypoperfusion
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Coronary Artery Calcification Score and the Progression of Chronic Kidney Disease J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Hae-Ryong Yun, Young Su Joo, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Nak-Hoon Son, Tae-Hyun Yoo, Shin-Wook Kang, Suah Sung, Kyu-Beck Lee, Joongyub Lee, Kook-Hwan Oh, Seung Hyeok Han
Background An elevated coronary artery calcification score (CACS) is associated with increased cardiovascular disease risk in patients with CKD. However, the relationship between CACS and CKD progression has not been elucidated. Methods We studied 1936 participants with CKD (stages G1–G5 without kidney replacement therapy) enrolled in the KoreaN Cohort Study for Outcome in Patients With CKD. The main
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A Deep Learning Approach for Automated Segmentation of Kidneys and Exophytic Cysts in Individuals with Autosomal Dominant Polycystic Kidney Disease J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Youngwoo Kim, Cheng Tao, Hyungchan Kim, Geum-Yoon Oh, Jeongbeom Ko, Kyongtae T. Bae
Background Total kidney volume (TKV) is an important imaging biomarker in autosomal dominant polycystic kidney disease (ADPKD). Manual computation of TKV, particularly with the exclusion of exophytic cysts, is laborious and time consuming. Methods We developed a fully automated segmentation method for TKV using a deep learning network to selectively segment kidney regions while excluding exophytic
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Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Michele Provenzano, Maria Jesús Puchades, Carlo Garofalo, Niels Jongs, Luis D’Marco, Michele Andreucci, Luca De Nicola, Jose Luis Gorriz, Hiddo J.L. Heerspink
Background Sodium glucose cotransporter 2 (SGLT2) inhibitors and mineralocorticoid receptor antagonists (MRAs) reduce the urinary albumin-to-creatinine ratio (UACR) and confer kidney and cardiovascular protection in patients with CKD. We assessed efficacy and safety of the SGLT2 inhibitor dapagliflozin and MRA eplerenone alone and in combination in patients with CKD. Methods We conducted a randomized
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Complementary Nck1/2 Signaling in Podocytes Controls {alpha} Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Claire E. Martin, Noah J. Phippen, Ava Keyvani Chahi, Manali Tilak, Sara L. Banerjee, Peihua Lu, Laura A. New, Casey R. Williamson, Mathew J. Platt, Jeremy A. Simpson, Mira Krendel, Nicolas Bisson, Anne-Claude Gingras, Nina Jones
Background Maintenance of the kidney filtration barrier requires coordinated interactions between podocytes and the underlying glomerular basement membrane (GBM). GBM ligands bind podocyte integrins, which triggers actin-based signaling events critical for adhesion. Nck1/2 adaptors have emerged as essential regulators of podocyte cytoskeletal dynamics. However, the precise signaling mechanisms mediated
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Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Karen I. López-Cayuqueo, Rosa Planells-Cases, Matthias Pietzke, Anna Oliveras, Stefan Kempa, Sebastian Bachmann, Thomas J. Jentsch
Background Volume-regulated anion channels (VRACs) are heterohexamers of LRRC8A with LRRC8B, -C, -D, or -E in various combinations. Depending on the subunit composition, these swelling-activated channels conduct chloride, amino acids, organic osmolytes, and drugs. Despite VRACs’ role in cell volume regulation, and large osmolarity changes in the kidney, neither the localization nor the function of
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Immunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Dhruti P. Chen, Elizabeth A. McInnis, Eveline Y. Wu, Katherine G. Stember, Susan L. Hogan, Yichun Hu, Candace D. Henderson, Lauren N. Blazek, Simon Mallal, Edita Karosiene, Bjoern Peters, John Sidney, Eddie A. James, William W. Kwok, J. Charles Jennette, Dominic J. Ciavatta, Ronald J. Falk, Meghan E. Free
Background PR3-ANCA vasculitis has a genetic association with HLA-DPB1. We explored immunologic and clinical features related to the interaction of HLA-DPB1*04:01 with a strongly binding PR3 peptide epitope (PR3225–239). Methods Patients with ANCA vasculitis with active disease and disease in remission were followed longitudinally. Peripheral blood mononuclear cells from patients and healthy controls
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Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Biswajit Padhy, Jian Xie, Runping Wang, Fang Lin, Chou-Long Huang
Background Mutations of PKD2, which encodes polycystin-2, cause autosomal dominant polycystic kidney disease (ADPKD). The prevailing view is that defects in polycystin-2–mediated calcium ion influx in the primary cilia play a central role in the pathogenesis of cyst growth. However, polycystin-2 is predominantly expressed in the endoplasmic reticulum (ER) and more permeable to potassium ions than to
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Myeloid CCR2 Promotes Atherosclerosis after AKI J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Anne M. Hüsing, Vera C. Wulfmeyer, Svenja Gaedcke, Susanne V. Fleig, Song Rong, David DeLuca, Hermann Haller, Roland Schmitt, Sibylle von Vietinghoff
Background The risk of cardiovascular events rises after AKI. Leukocytes promote atherosclerotic plaque growth and instability. We established a model of enhanced remote atherosclerosis after renal ischemia-reperfusion (IR) injury and investigated the underlying inflammatory mechanisms. Methods Atherosclerotic lesions and inflammation were investigated in native and bone marrow–transplanted LDL receptor–deficient
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Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Shinobu Miyazaki-Anzai, Audrey L. Keenan, Judith Blaine, Makoto Miyazaki
Background The proximal tubules play a critical role in phosphate (Pi) homeostasis by reabsorbing Pi via sodium-dependent Pi cotransporters. NPT2A is a major proximal-specific Pi cotransporter, whose expression is regulated by circulating hormones, such as parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). In this study, we aimed to find a novel regulator in Pi homeostasis. Methods
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Optimizing the Design and Analysis of Future AKI Trials J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Matthieu Legrand, Sean M. Bagshaw, Jay L. Koyner, Ivonne H. Schulman, Michael R. Mathis, Juliane Bernholz, Steven Coca, Martin Gallagher, Stéphane Gaudry, Kathleen D. Liu, Ravindra L. Mehta, Romain Pirracchio, Abigail Ryan, Dominik Steubl, Norman Stockbridge, Fredrik Erlandsson, Alparslan Turan, F. Perry Wilson, Alexander Zarbock, Michael P. Bokoch, Jonathan D. Casey, Patrick Rossignol, Michael O.
AKI is a complex clinical syndrome associated with an increased risk of morbidity and mortality, particularly in critically ill and perioperative patient populations. Most AKI clinical trials have been inconclusive, failing to detect clinically important treatment effects at predetermined statistical thresholds. Heterogeneity in the pathobiology, etiology, presentation, and clinical course of AKI remains
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High-Resolution Mass Spectrometry for the Measurement of PTH and PTH Fragments: Insights into PTH Physiology and Bioactivity J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Candice Z. Ulmer, Kittrawee Kritmetapak, Ravinder J. Singh, Hubert W. Vesper, Rajiv Kumar
Full-length parathyroid hormone (PTH 1–84) is crucial for the regulation of calcium and phosphate homeostasis and bone remodeling. PTH 1–84 is metabolized into various PTH fragments, which are measured with varying levels of efficiency by PTH immunoassays. These PTH fragments, which increase in serum as CKD progresses, could potentially modulate the effects of PTH 1–84 and contribute to CKD-associated
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Sex Differences in the Recognition, Monitoring, and Management of CKD in Health Care: An Observational Cohort Study J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-29 Oskar Swartling, Yuanhang Yang, Catherine M. Clase, Edouard L. Fu, Manfred Hecking, Sebastian Hödlmoser, Ylva Trolle-Lagerros, Marie Evans, Juan J. Carrero
Introduction Reported sex differences in the etiology, population prevalence, progression rates, and health outcomes of people with CKD may be explained by differences in health care.Methods We evaluated sex as the variable of interest in a health care–based study of adults (n=227,847) with at least one outpatient eGFR<60 ml/min per 1.73 m2 measurement denoting probable CKD in Stockholm from 2009 to
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Systematic Review and Meta-Analysis of Plasma and Urine Biomarkers for CKD Outcomes J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-20 Caroline Liu, Neha Debnath, Gohar Mosoyan, Kinsuk Chauhan, George Vasquez-Rios, Celine Soudant, Steve Menez, Chirag R. Parikh, Steven G. Coca
Background Sensitive and specific biomarkers are needed to provide better biologic insight into the risk of incident and progressive CKD. However, studies have been limited by sample size and design heterogeneity.Methods In this assessment of the prognostic value of preclinical plasma and urine biomarkers for CKD outcomes, we searched Embase (Ovid), MEDLINE ALL (Ovid), and Scopus up to November 30
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Association of Rosuvastatin Use with Risk of Hematuria and Proteinuria J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-19 Jung-Im Shin, Derek M. Fine, Yingying Sang, Aditya Surapaneni, Stephan C. Dunning, Lesley A. Inker, Thomas D. Nolin, Alex R. Chang, Morgan E. Grams
Visual Abstract
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NMR Metabolomic Profiling and Urine Chemistries in Incident Kidney Stone Formers Compared to Controls J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-19 Charat Thongprayoon, Ivan Vuckovic, Lisa Vaughan, Slobodan Macura, Nicholas Larson, Matthew D'Costa, John Lieske, Andrew Rule, Aleksandar Denic
Background: The urine metabolites and chemistries that contribute to kidney stone formation are not fully understood. This study examined differences between the urine metabolic and chemistries profiles of first-time stone formers and controls. Methods: High resolution 1H-nuclear magnetic resonance (NMR) spectroscopy-based metabolomic analysis was performed in 24-hour urines from a prospective cohort
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The Highs and Lows of Potassium Intake in Chronic Kidney Disease - Does One Size Fit All? J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-19 Andrew Terker,Turgay Saritas,Alicia McDonough
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Hurricanes and Mortality among Patients Receiving Dialysis J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-14 Matthew F. Blum, Yijing Feng, G. Brooke Anderson, Dorry L. Segev, Mara McAdams-DeMarco, Morgan E. Grams
Background Hurricanes are severe weather events that can disrupt power, water, and transportation systems. These disruptions may be deadly for patients requiring maintenance dialysis. We hypothesized that the mortality risk among patients requiring maintenance dialysis would be increased in the 30 days after a hurricane.Methods Patients registered as requiring maintenance dialysis in the United States
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Assessing the Carbon Footprint of Hemodialysis: A First Step Toward Environmentally Sustainable Kidney Care. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-15 Katherine A Barraclough,Scott McAlister
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Unfulfilled Expectations Open New Horizons: What Have We Learned about Volume-Regulated Anion Channels in the Kidney? J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-15 Oleh Pochynyuk,Oleg Palygin
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Cation Channel Activity of Apolipoprotein L1 is Modulated by Haplotype Background. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-15 Rebecca L Winkler,Jonathan Bruno,Paula Buchanan,John C Edwards
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On the Importance of Considering Glycosylation When Evaluating Biologic Therapies. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-15 Mathieu Lemaire
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Authors' Reply: "On the Importance of Considering Glycosylation when Evaluating Biologic Therapies". J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-15 Andrea Angeletti,Pietro Ravani,Maurizio Bruschi,Gian Marco Ghiggeri
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Complement is Complimentary in Membranous Nephropathy. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-13 Ralph Kettritz,Adrian Schreiber
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Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Shuang Gao, Zhao Cui, Ming-hui Zhao
Background The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.Methods C3aR expression in kidneys and circulating levels of C3a of MN patients were examined. Human podocyte damage
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Sources of Variation in the Carbon Footprint of Hemodialysis Treatment J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Ashwini R. Sehgal, Jonathan E. Slutzman, Anne M. Huml
Background Greenhouse gas emissions from hemodialysis treatment in the United States have not been quantified. In addition, no previous studies have examined how much emissions vary across facilities, treatments, and emission contributors.Methods To estimate the magnitude and sources of variation in the carbon footprint of hemodialysis treatment, we estimated life-cycle greenhouse gas emissions in
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Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Jarcy Zee, Qian Liu, Abigail R. Smith, Jeffrey B. Hodgin, Avi Rosenberg, Brenda W. Gillespie, Lawrence B. Holzman, Laura Barisoni, Laura H. Mariani
Background Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural changes most predictive of clinical outcomes in the Nephrotic Syndrome Study Network (NEPTUNE). Methods Forty-eight histologic (37 glomerular, 9 tubulointerstitial
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Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Lucile Figueres, Sarah Bruneau, Caroline Prot-Bertoye, Gaëlle Brideau, Mélanie Néel, Camille Griveau, Lydie Cheval, Yohan Bignon, Jordan Dimitrov, Thomas Dejoie, Simon Ville, Christine Kandel-Aznar, Anne Moreau, Pascal Houillier, Fadi Fakhouri
Background Chronic hypomagnesemia is commonly due to diarrhea, alcoholism, and drugs. More rarely, it is caused by genetic defects in the effectors of renal magnesium reabsorption. Methods In an adult patient with acquired severe hypomagnesemia, hypocalcemia, tubulointerstitial nephropathy, and rapidly progressing kidney injury, similarities between the patient’s presentation and features of genetic
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Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Benjamin Lidgard, Nisha Bansal, Leila R. Zelnick, Andrew Hoofnagle, Jing Chen, Derek Colaizzo, Mirela Dobre, Katherine T. Mills, Anna C. Porter, Sylvia E. Rosas, Mark J. Sarnak, Stephen Seliger, James Sondheimer, Manjula Kurella Tamura, Kristine Yaffe, Bryan Kestenbaum, the CRIC Study Investigators
Background People with chronic kidney disease (CKD) are at high risk for cognitive impairment and progressive cognitive decline. Retention of protein-bound organic solutes that are normally removed by tubular secretion is hypothesized to contribute to cognitive impairment in CKD. Methods We followed 2362 participants who were initially free of cognitive impairment and stroke in the prospective Chronic
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The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Josef Fritz, Wolfgang Brozek, Hans Concin, Gabriele Nagel, Julia Kerschbaum, Karl Lhotta, Hanno Ulmer, Emanuel Zitt
Background Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight and CKD risk. However, the magnitude of the total effect of excess body weight on ESKD mediated through these four pathways remains to be quantified. Methods We applied a model for analysis of correlated mediators to population-based
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Aqp2+ Progenitor Cells Maintain and Repair Distal Renal Segments J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Chao Gao, Long Zhang, Enuo Chen, Wenzheng Zhang
Background Adult progenitor cells presumably demonstrate clonogenicity, self-renewal, and multipotentiality, and can regenerate cells under various conditions. Definitive evidence demonstrating the existence of such progenitor cells in adult mammalian kidneys is lacking. Method We performed in vivo lineage tracing and thymidine analogue labeling using adult tamoxifen-inducible (Aqp2ECE/+ RFP/+, Aqp2ECE/+
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Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Zoe McArdle, Reetu R. Singh, Helle Bielefeldt-Ohmann, Karen M. Moritz, Michiel F. Schreuder, Kate M. Denton
Background Children born with a solitary functioning kidney (SFK) are predisposed to develop hypertension and kidney injury. Glomerular hyperfiltration and hypertrophy contribute to the pathophysiology of kidney injury. Angiotensin-converting enzyme inhibition (ACEi) can mitigate hyperfiltration and may be therapeutically beneficial in reducing progression of kidney injury in those with an SFK. Methods
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Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Martin Schepelmann, Marianna Ranieri, Irene Lopez-Fernandez, Thomas S. Webberley, Sarah C. Brennan, Polina L. Yarova, Joao Graca, Umar-Khetaab Hanif, Christian Müller, Teresa Manhardt, Martina Salzmann, Helen Quasnichka, Sally A. Price, Donald T. Ward, Thierry Gilbert, Vladimir V. Matchkov, Robert A. Fenton, Amanda Herberger, Jenna Hwong, Christian Santa Maria, Chia-Ling Tu, Enikö Kallay, Giovanna
Background Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells exacerbates vascular calcification in vitro. Conversely, vascular calcification can be reduced by calcimimetics
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Single-Cell Chromatin and Gene-Regulatory Dynamics of Mouse Nephron Progenitors J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-07-01 Sylvia Hilliard, Giovane Tortelote, Hongbing Liu, Chao-Hui Chen, Samir S. El-Dahr
Background We reasoned that unraveling the dynamic changes in accessibility of genomic regulatory elements and gene expression at single-cell resolution will inform the basic mechanisms of nephrogenesis. Methods We performed single-cell ATAC-seq and RNA-seq both individually (singleomes; Six2GFP cells) and jointly in the same cells (multiomes; kidneys) to generate integrated chromatin and transcriptional
更新日期：2022-08-11
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