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Effects of Clazakizumab on Anemia and Iron Metabolism in Patients with Kidney Failure. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-05 Brendon L Neuen,Benjamin Catanese,Annamarie Chang,Mark Heise,Pierluigi Tricoci,G Michael Felker,Kenneth W Mahaffey,Myles Wolf,Glenn M Chertow,
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Why Is C5a Inflammatory Complement Inhibition Not Enough to Improve C3 Glomerulopathy? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-04 Peter F Zipfel,Christine Skerka
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Increasing the Removal of Large Solutes by Kidney Replacement Therapy. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-04 Timothy W Meyer
Solutes that accumulate when the kidneys fail range in size from about 40 to 40,000 Da. Their dialytic clearance tends to decrease as their size increases. Disproportionate accumulation of large solutes has therefore long been considered a potential contributor to residual illness in dialysis patients. Early efforts focused on the removal of "middle molecules" with mass from 300 to 2000 Da. The identification
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Genotype-Based Molecular Mechanisms in Alport Syndrome. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-03 Emine Bilge Caparali,Vanessa De Gregorio,Moumita Barua
Alport syndrome (AS) is an inherited disorder characterized by kidney disease, sensorineural hearing loss and ocular abnormalities. AS is caused by pathogenic variants in COL4A3, COL4A4 or COL4A5, which encode the α3, α4 and α5 chains of type IV collagen that forms a heterotrimer expressed in the glomerular basement membrane. Knowledge of its genetic basis has informed the development of different
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Characterization of the Cystic Phenotype Associated with Monoallelic ALG8 and ALG9 Pathogenic Variants. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-03 Tabinda Jawaid,Doaa E Elbarougy,Sravanthi Lavu,Guillaume Buia,Sarah R Senum,Eric Olinger,Hana Yang,Shannon K McDonnell,Joshua T Bublitz,Jun Ma,Marie-Pierre Audrézet,Charles D Madsen,Rachel S Schauer,Tracy A Baker,Adriana V Gregory,Sarah G Orr,Miguel Barroso-Gil,Ruxandra Neatu,Giancarlo Joli,Neera K Dahl,Timothy L Kline,Valentine Gillion,Karin Dahan,Francois Jouret,Ronald D Perrone,Theodore I Steinman
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is a common, inherited nephropathy often resulting in kidney failure. It is genetically heterogeneous; along with the major genes, PKD1 and PKD2, at least 8 others have been suggested. ALG8 pathogenic variants have been associated with autosomal dominant polycystic liver disease and implicated in ADPKD, while ALG9 has been suggested as
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What Are Baskets, Umbrellas, and Platforms Doing in Nephrology Clinical Trials? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-03 Julie Lin,Jai Radhakrishnan
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Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-31 Niklas Worm Andersson,Xiaoping Wu,Frank Geller,Jan Wohlfahrt,Mads Melbye,Anders Hviid,Michael Schwinn,Christina Mikkelsen,Joseph Dowsett,Mie Topholm Bruun,Bitten Aagaard,Henrik Ullum,Christian Erikstrup,Daniel Fannar Gudbjartsson,Kári Stefánsson,Jonas Ghouse,Ole Birger Pedersen,Erik Sørensen,Sisse Rye Ostrowski,Henning Bundgaard,Marie Lund,Bjarke Feenstra,
BACKGROUND Abnormal plasma sodium concentration represents an imbalance of total body water relative to electrolyte content. Hyponatremia is a common and potentially severe adverse event, and thiazide diuretics constitute a leading cause of drug-induced hyponatremia. METHODS We conducted genome-wide association study analyses of plasma sodium concentration, thiazide-induced decrease in sodium concentration
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Authors' Reply: Competing Risk Models Should Be Considered When Estimating Kidney Allograft Failure. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-31 Agathe Truchot,Marc Raynaud,Alexandre Loupy
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Pathogenesis of Organ Damage in Fabry Disease: The AGALopathy Pathogenetic Pathway. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-31 Paula Rozenfeld,Sandro Feriozzi
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Competing Risk Models Should Be Considered When Estimating Kidney Allograft Failure. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-31 Jan H Lindeman,Hein Putter,Ian P J Alwayn,Esther Bastiaannet
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Autoantibodies in the Pathogenesis of Podocytopathies. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-30 Lukas Blume,Catherine Meyer-Schwesinger
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KidneyintelX.dkd: An Innovation in Precision Medicine for Diabetic Kidney Disease. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-30 Steven G Coca,Girish N Nadkarni
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Anti-slit Antibodies against Podocin and Kirrel1 in Pediatric and Adult Podocytopathies. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-30 Valentina Raglianti,Maria Lucia Angelotti,Letizia De Chiara,Marco Allinovi,Luigi Cirillo,Anna Manonelles Montero,Josep Maria Cruzado,Maria Elena Melica,Giulia Antonelli,Carolina Conte,Anna Julie Peired,Laura Lasagni,Bärbel Lange-Sperandio,Hans-Joachim Anders,Francesca Becherucci,Elena Lazzeri,Benedetta Mazzinghi,Paola Romagnani
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Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula via YAP1 Signaling. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-30 Yongdong Wu,Tae Hoon Lee,Owen H Cheng,Eric Peden,Qingtian Li,Jun Wang,Fengzhang Huang,Marites P Melancon,David Sheikh-Hamad,Tao Wang,Luan Truong,William Mitch,Ming Liang,Jizhong Cheng
BACKGROUND Arteriovenous (AV) fistulas are the preferred access for dialysis but have a high incidence of failure. This study aims to understand the crosstalk between skeletal muscle catabolism and AV fistula maturation failure. METHODS Skeletal muscle metabolism and AV fistula maturation were evaluated in mice with chronic kidney disease (CKD). The roles of myostatin and YAP1 in regulating the transdifferentiation
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MAIT Cell-Mediated Immune Mechanisms of Dialysis-Induced Peritoneal Fibrosis and Therapeutic Targeting. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-28 Yuxiang Sun,Qiang Huang,Juan Sun,Hu Zhou,Dandan Guo,Long Peng,Hongchun Lin,Canming Li,Hongli Shang,Tongtong Wang,Yanxu Chen,Yong Huang,Cheng Hu,Zhaoyong Hu,Yan Lu,Hui Peng
BACKGROUND Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD) and abdominal surgeries, yet effective treatments remain elusive. Given the known roles of mucosal-associated invariant T (MAIT) cells in immune responses and fibrotic diseases, we investigated their involvement in PD-induced peritoneal fibrosis to identify potential therapeutic targets. METHODS We employed
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Mechanotransduction and the Integrity of the Slit Diaphragm. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-28 Rose Z Hill
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Integrin Trafficking, Fibronectin Architecture, and Glomerular Injury upon AdipoR1 Depletion. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-28 Sonja Lindfors,Constanze Schmotz,Dominik Lewandowski,Annika Hau,Leena Saikko,Eero Lehtonen,Ville Majaniemi,Minna Karhe,Jette-Britt Naams,Harry Nisen,Jukka Tienari,Moin A Saleem,Katharina Pfeil,Heiko Bugger,Kirsi H Pietiläinen,Tuomas Mirtti,Krzysztof Palczewski,Sanna Lehtonen
BACKGROUND Deficiency of adiponectin and its downstream signaling may contribute to the pathogenesis of kidney injury in type 2 diabetes. Adiponectin activates intracellular signaling via adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2), but the role of AdipoR-mediated signaling in glomerular injury in type 2 diabetes remains unknown. METHODS The expression of AdipoR1 in the kidneys of people with
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Testing Interventions that Address Kidney Health Disparities. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-12-23 Keisha Bentley-Edwards,LáShauntá Glover,Amber E Johnson,Dinushika Mohottige,Joy E Obayemi,Stefany Olague,Melvin Thompson,Sri Lekha Tummalapalli,Megan Urbanski,Huiman Barnhart,Christina M Wyatt,
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N-acetyl-tryptophan in Acute Kidney Injury after Cardiac Surgery. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-23 Ning Shi,Ji-Wen Wang,Gengchen Su,Gaoxiang Ma,Feng-Qing Huang,Si-Jia Jin,Hua-Mei Xie,Wen-Xin Ge,Jiang-Ping Song,Xiaodong Luan,Lei Zhang,Lian-Wen Qi
BACKGROUND Cardiac surgery-associated acute kidney injury is a common serious complication after cardiac surgery. Currently, there are no specific pharmacological therapies. Our understanding of its pathophysiology remains preliminary. METHODS A total of 2504 patients with and without acute kidney injury (AKI) following cardiac surgery were enrolled. High-performance liquid chromatography coupled with
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Tuberculosis in the US Kidney Failure Population. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-23 Kimberly R Schildknecht,Molly Deutsch-Feldman,Jason Cummins,Divia P Forbes,Maryam B Haddad,Ibironke W Apata,Jonathan M Wortham
BACKGROUND People with chronic kidney disease (CKD) have a higher risk for progression to tuberculosis disease following infection with Mycobacterium tuberculosis. We produced a nationwide incidence estimate and description of tuberculosis among people with kidney failure. METHODS We completed a cross-sectional descriptive analysis of people with a reported case of tuberculosis in the United States
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Glomerular Hyperfiltration and Tubuloglomerular Feedback in Diabetic Kidney Disease: Physiological Insights and Potential Clinical Translation. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-22 Rikke Borg,David Zi Cherney
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Finding and Profiling Renal Cells with Spatial Transcriptomics. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-21 Katherine R Bull
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The Calcium-Sensing Receptor in the Thick Ascending Limb and the Renal Response to Hypercalcemia. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-21 Nina Himmerkus,Catarina Quintanova,Harneet Bhullar,Wouter H van Megen,Amanda Lima Deluque,Karsten Skjødt,Milos Bogdanovic,Markus Bleich,Todd Alexander,Henrik Dimke
BACKGROUND The parathyroid calcium-sensing receptor (CASR) controls the release of parathyroid hormone (PTH) in response to changes in serum calcium levels. Activation of the renal CASR increases urinary calcium excretion and is particularly important when CASR-dependent reductions in PTH fail to lower serum calcium. However, the role of the renal CASR in protecting against hypercalcemia and the direct
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Polycystic Kidney Disease: A Disorder Out of Time? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-21 Fabian Braun,Roman-Ulrich Müller
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Use of a Context- and Equity-Focused Implementation Science Framework to Aid the Design of Clinical Trials. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-17 Lilia Cervantes,Katherine Rizzolo,Sri Lekha Tummalapalli,Marina Wainstein,Russell E Glasgow,Mónica Pérez Jolles
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Biomarker Panels for Discriminating Risk of CKD Progression in Children. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-16 Jason H Greenberg,Alison G Abraham,Yunwen Xu,Jeffrey R Schelling,Steven G Coca,Sarah J Schrauben,F Perry Wilson,Sushrut S Waikar,Ramachandran S Vasan,Orlando M Gutierrez,Michael G Shlipak,Joachim H Ix,Bradley A Warady,Paul L Kimmel,Joseph V Bonventre,Chirag R Parikh,Michelle Denburg,Susan Furth,
BACKGROUND We have previously studied biomarkers of tubular health (EGF), injury (KIM-1), dysfunction (alpha-1 microglobulin), and inflammation (TNFR-1, TNFR-2, MCP-1, YKL-40, suPAR), and demonstrated that plasma KIM-1, TNFR-1, TNFR-2 and urine KIM-1, EGF, MCP-1, urine alpha-1 microglobulin are each independently associated with CKD progression in children. In this study, we used bootstrapped survival
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Utilization of Telemedicine for Patients Receiving In-center Hemodialysis in the United States. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-16 Jingbo Niu,Omar Rosales,Abiodun Oluyomi,Susie Q Lew,Glenn M Chertow,Wolfgang C Winkelmayer,Kevin F Erickson
BACKGROUND In March 2020, responding to the COVID-19 pandemic, federal emergency waivers in the United States enabled kidney care providers (nephrologists and advanced practice providers) to substitute face-to-face in-center hemodialysis visits with telemedicine encounters. We examined whether the frequency of kidney care provider visits and hospitalizations were associated with telemedicine use in
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Restrictive or Liberal Blood Transfusion in Patients with Myocardial Infarction and CKD. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-09 Jordan B Strom,Brandon M Herbert,Marnie Bertolet,Maria M Brooks,Shahbaz A Malik,Gilles Lemesle,Mina Madan,Philippe Gabriel Steg,Paul C Hebert,Jay H Traverse,Harvey D White,Caroline Alsweiler,Rajesh Gupta,Luiz Eduardo F Ritt,Mark A Menegus,John H Alexander,Renato D Lopes,Bernard R Chaitman,Jeffrey L Carson,
BACKGROUND Chronic kidney disease (CKD) is associated with higher risk of myocardial infarction and anemia. Among patients with anemia and CKD who experience myocardial infarction, it remains uncertain if a liberal red blood cell transfusion threshold strategy (hemoglobin cutoff [Hgb] < 10 g/dL) is superior to a restrictive transfusion threshold (Hgb 7-8 g/dL) strategy. METHODS Among the 3,504 patients
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Exon Skipping Therapies for Rare Kidney Diseases. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-08 Tomohiko Yamamura,Kandai Nozu
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Genotype–Phenotype Correlations with TRPC6-Associated Podocytopathy J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-07 Jing Miao, Ladan Zand
An abstract is unavailable.
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Advancing Understanding of Cardiovascular Risk in CKD J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-07 Vikas S. Sridhar, Ayodele Odutayo
An abstract is unavailable.
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Combination Therapy with SGLT2 Inhibitors and GLP-1 Receptor Agonists for Diabetic Kidney Disease. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-07 Mengyao Tang,Mario Luca Morieri,Sahir Kalim,Alessandro Doria
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Innovations in Targeting the V2 Receptor J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-07 Francesco Trepiccione, Anna Iervolino
An abstract is unavailable.
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When a NeF Is Not Enough: Improving Assays in C3 Glomerulopathy J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-07 Pietro Canetta
An abstract is unavailable.
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Notch2 Inhibition and Kidney Cyst Growth in Autosomal Dominant Polycystic Kidney Disease. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-02 Huiwen Ren,Chengsen Mu,Yuhan Wang,Yuanyuan Cheng,Yayan Hou,Yizhe Li,Na Liu,Zhuming Yin,Hui Xiong,Yupeng Chen,Tianxin Yang,Ying Yu,Yujun Shen
BACKGROUND Notch signaling, a conserved mechanism of cell-to-cell communication, plays a crucial role in regulating cellular processes such as proliferation and differentiation in a context-dependent manner. However, the specific contribution of Notch signaling to the progression of polycystic kidney disease (PKD) remains unclear. METHODS We investigated the changes in Notch signaling activity (Notch1-4)
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Opening New Routes for Kidney Therapy. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-30 Sara Kinstlinger,Moran Dvela-Levitt
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Podocyte-Mediated Protection from Kidney Injury J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-27 Sanna Lehtonen, Seppo Meri
An abstract is unavailable.
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Shear Forces and the Vulnerability of the Podocyte J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-27 Josephine P. Briggs, Mark A. Knepper
An abstract is unavailable.
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Practical Considerations for Sharing Race-Based Genetic Research Findings. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-26 Ana Iltis,Glenda V Roberts,Marva Moxey-Mims,Alexis Conell,Jennifer Davis,Rasheed Gbadegesin,Patrick Gee,Nichole Jefferson,Heather Johnson,Giftay Kingston,Kathryn Lindsay,Mariella Ortigosa-Goggins,Sylvia Rosas,Laurie Russell,Krista L Lentine,
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Nanotherapeutics in Kidney Disease: Innovations, Challenges, and Future Directions. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-20 Amir Roointan,Rong Xu,Simon Corrie,Christoph E Hagemeyer,Karen Alt
The treatment and management of kidney disease present a significant global challenge, affecting over 800 million individuals and necessitating innovative therapeutic strategies that transcend symptomatic relief. The application of nanotechnology to renal therapies, while still in its early stages, holds transformative potential for improving treatment outcomes. Recent advancements in nanoparticle-based
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Autopsy of a Hemodialysis Machine: Potential for Recycling at the End of the Life Cycle. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-13 Carole Bonnet,Massimo Torreggiani,Lavinia Bianco,Frédéric Amiard,Zeyad Elsalhy,Ajla Grozdanic,Hana Grozdanic,Anastasia Vladimira Sizov,Makrem Kayel,Michaël Saulnier,Gaëlle Vayssieres,Hafedh Fessi,Nicolas Delorme,Giorgina Barbara Piccoli
BACKGROUND Hemodialysis (HD) contributes significantly to healthcare's carbon footprint. Worldwide about 100,000 dialysis machines end their life cycle each year. Our aim was to analyze the composition and the potential for recyclability of two dialysis machines, from the two companies with the largest market share, which had met their end-of-use terms (10-12 years of use according to French regulations)
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Developmental and Cell Fate Analyses Support a Postnatal Origin for the Cortical Collecting System in the Mouse Kidney. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-11 Riana K Parvez,Réka L Csipán,Jing Liu,Ara Gevorgyan,Elisabeth A Rutledge,Jinjin Guo,Doh Kyung Kim,Andrew P McMahon
BACKGROUND Structure and function in the mammalian kidney are organized along a radial axis highlighted by the corticomedullary organization and regional patterning of the collecting system. The arborised collecting epithelium arises through controlled growth, branching and commitment of Wnt11+ ureteric progenitor cells within cortically localized branch tips until postnatal day 3. METHODS We applied
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Macrophage-Derived Type 1 IFN, Renal Tubular Epithelial Cell Polyploidization, and AKI-to-CKD Transition. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-11 Yaqin Wang,Qigang Lan,Fugang Li,Jiachuan Xiong,Hailun Xie,Shuiqin Gong,Mengying Yao,Liangjing Lv,Shaozong Qin,Wang Xin,Aihong Zhang,Siyan Zhou,Yinghui Huang,Jinghong Zhao
BACKGROUND Acute kidney injury (AKI) is recognized as a common risk factor for chronic kidney disease (CKD). Renal tubular epithelial cell polyploidization after AKI is closely associated with maladaptive repair, while the regulatory and molecular mechanisms remain poorly understood. Here, we set out to investigate the mechanism of tubular epithelial cell polyploidization and their role in the AKI-to-CKD
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Contributions from the Implementation Science Field to Clinical Trial Design for Kidney Research: Hybrid Effectiveness-Implementation Studies. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-10 Lilia Cervantes,Monica Perez Jolles,Katherine Rizzolo,Ladan Golestaneh,Russell E Glasgow
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The Win Ratio for Composite Outcomes in Nephrology Clinical Trials. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-10 João Pedro Ferreira,Faiez Zannad
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ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-09 Marten Junge,Nastassia Liaukouskaya,Nicole Schwarz,Carolina Pinto-Espinoza,Alessa Z Schaffrath,Björn Rissiek,Christian F Krebs,Guido Rattay,Hans-Willi Mittrücker,Nicola M Tomas,Annette Nicke,Friedrich Haag,Tobias B Huber,Catherine Meyer-Schwesinger,Friedrich Koch-Nolte,Nicola Wanner
BACKGROUND The P2X7 ion channel, a key sensor of sterile inflammation, has been implicated as a therapeutic target in glomerulonephritis, and P2X7-antagonistic nanobodies can attenuate experimental glomerulonephritis. However, little is known about the expression of P2X7 on renal immune cells. METHODS We used conventional immunofluorescence of kidney sections as well as intraperitoneal injection of
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Using VNtyper from Whole Exome Sequencing Data to Detect Pathogenic Variants in the MUC1 Gene J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-09 Hassan Saei, Cécile Masson, Vincent Morinière, Jessica Kachmar, Laurence Heidet, Olivier Gribouval, Corinne Antignac, Guillaume Dorval
An abstract is unavailable.
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Authors' Reply: Using VNtyper from Whole Exome Sequencing Data to Detect Pathogenic Variants in the MUC1 Gene J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-09 Ilias Bensouna, Thomas Robert, Xavier Vanhoye, Laurent Mesnard
An abstract is unavailable.
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Pediatric Nephrology Workforce and Access of Children with Kidney Failure to Transplantation in the United States. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-06 Gabriela Accetta Rojas,Charles E McCulloch,Timothy P Copeland,Adrian M Whelan,Alexandra C Bicki,Sophia Giang,Barbara A Grimes,Elaine Ku
BACKGROUND Nephrology is one of the pediatric subspecialties with the largest workforce shortage in the US. Waitlist registration is one of the first steps towards kidney transplantation and is facilitated by pediatric nephrologists. The objective of this study was to determine whether state-level density of pediatric nephrologists is associated with access to waitlisting (primary outcome) or kidney
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TRPML-1 Dysfunction and Renal Tubulopathy in Mucolipidosis Type IV. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-04 Giuseppina Grieco,Sandro Montefusco,Edoardo Nusco,Antonella Capuozzo,Francesca Cervellini,Elena Polishchuk,Martha Bishop,Antonio Miele,Luciano D'Apolito,Claudia La Vecchia,Miriam Aurilia,Michela Schiavo,Leopoldo Staiano,Marcella Cesana,Rebecca Oberman,Anna V Lynch,Patricia Musolino,Francesco Trepiccione,Yulia Grishchuk,Diego Luis Medina
BACKGROUND Loss of function mutations in the lysosomal channel TRPML-1 cause mucolipidosis type IV (MLIV), a rare lysosomal storage disease characterized by neurological defects, progressive vision loss, and achlorhydria. Recent reports have highlighted kidney disease and kidney failure in patients with MLIV during the second to third decade of life; however, the molecular mechanisms driving kidney
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Disparities in Care: Desperate for Modality Education J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-03 Jenny I. Shen, Jeffrey Perl
An abstract is unavailable.
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Need to Advance Pain Management in Kidney Failure beyond Opioid Medications J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-03 Kirsten L. Johansen
An abstract is unavailable.
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ST2+ T-Regulatory Cells as a Potential Immunotherapy Target for Kidney Fibrosis J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-03 Allison E. Norlander, David P. Basile
An abstract is unavailable.
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Autonomic Dysfunction and Inflammation in CKD: A High-Risk Pathway. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-02 Carmine Zoccali,Francesca Mallamaci,Mehmet Kanbay,Evangelia Dounousi,Peter Kotanko,Joachim Jankowski,Glenn M Chertow
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Immigration Status Checks, Emergency Medicaid Utilization, and Health Care Access for Uninsured Individuals with Kidney Disease J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-12-02 Katherine Rizzolo, Ryan Murray, Jade Teakell, Eric Kerns, Prakrati Acharya, Priti Patel, Prachi Sharma, Lilia Cervantes, on behalf of the Expanding Access to Kidney Care for Uninsured Individuals Workgroup of the ASN Health Care Justice Committee
An abstract is unavailable.
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Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter 2 Inhibitor Prescriptions in Type 2 Diabetes by Kidney and Cardiovascular Disease J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-11-27 Sneha S. Mehta, Aditya L. Surapaneni, Krutika Pandit, Yunwen Xu, Leora Horwitz, Saul Blecker, Matthew F. Blum, Alexander R. Chang, Jung-Im Shin, Morgan E. Grams
An abstract is unavailable.
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Prevalence and Impact of APOL1 Kidney Risk Variants in West Africa : Insights for Global Kidney Disease Assessment and Treatment. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-11-27 Elena Martinelli,Rik Westland,Opeyemi A Olabisi,Simone Sanna-Cherchi
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Understanding Better the Genetic Causes of Hematuria J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-11-27 Judy Savige
An abstract is unavailable.
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Metabolic Breakdown: The Hidden Role of Endothelial Glycolysis in Kidney Fibrosis J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-11-27 Pinelopi P. Kapitsinou
An abstract is unavailable.
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Labor and Delivery Outcomes in Australian Mothers after Kidney Transplantation. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-11-25 Nishanta Tangirala,Erandi Hewawasam,Christopher E Davies,Amanda Poprzeczny,Elizabeth Sullivan,Stephen P McDonald,Shilpanjali Jesudason