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Acetazolamide and Glomerular Hyperfiltration in Type 1 Diabetes: Additional Insights from Early Clinical Research. J. Am. Soc. Nephrol. (IF 9.4) Pub Date : 2025-06-23 Thierry Hannedouche
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Biomarkers of Kidney Failure and All-Cause Mortality in CKD. J. Am. Soc. Nephrol. (IF 9.4) Pub Date : 2025-06-20 Anthony Onoja,Thomas McDonnell,Isabelle Annessi,Rosamonde E Banks,Marianne Bergin,Paul Cockwell,Rodolphe Dusaulcy,Simon D S Fraser,Tim Johnson,Philip A Kalra,Barbara Lemaître,Moin Saleem,Phillipp Skroblin,Magnus Soderberg,Maarten W Taal,Robert J Unwin,Nicolas Vuilleumier,David C Wheeler,Nophar Geifman
BACKGROUND Chronic kidney disease (CKD) carries a variable risk for multiple adverse outcomes, highlighting the need for a personalised approach. This study evaluated several novel biomarkers linked to key disease mechanisms to predict the risk of kidney failure (first event of eGFR <15 ml/min/1.73m2 or kidney replacement therapy), all-cause mortality, and a composite of both. METHODS We included 2
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How Participatory Research Can Inform Antiracism Approaches to Advance Kidney Health Equity. J. Am. Soc. Nephrol. (IF 9.4) Pub Date : 2025-06-20 Abdou Simon Senghor,Godwin Okoye,Chandra L Ford,Deidra C Crews,Keith C Norris
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Endothelial Progenitor Cells: Disease Markers and Potential Therapy in Kidney Disease. J. Am. Soc. Nephrol. (IF 9.4) Pub Date : 2025-06-20 Shahd Al Heijani,Mohamed Naim Khalil,Salsabil Haque,LaTonya J Hickson,Amir Lerman,Lilach O Lerman
Endothelial progenitor cells (EPCs) constitute a promising focus for research in regenerative medicine. These cells originate from the bone marrow and other circulating hematopoietic cells and regulate tissue regeneration and vascular integrity. EPCs mobilization serves for neovascularization and reendothelialization after injury in multiple organ systems, including the renal and cardiovascular systems
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Cardiac LIM Protein, Kidney Fibrosis, and Vascular Change after Acute Cardiorenal Syndrome. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-19 Yoshio Funahashi,Jessica F Hebert,Adam Munhall,Daiki Aomura,Kevin G Burfeind,Elizabeth D Nguyen,Tahnee Groat,Megan N Nickerson,Mahaba B Eiwaz,Jonathan W Nelson,Nicole K Andeen,Motoko Yanagita,Susan B Gurley,Michael P Hutchens
BACKGROUND Heart and kidney are bi-directionally interacting organs. Because heart and kidney disease are amongst the most common human diseases, investigating disease-causing interactions is important. Here, we identified a new role for cardiac-derived cardiac LIM protein, also known as cysteine-and-glycine-rich protein 3 (CSRP3), in acute cardiorenal syndrome. METHODS Mice, both wild-type and genetically-altered
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Discontinuation of Renin-Angiotensin System Inhibitors during Acute Kidney Injury Episode and All-cause Mortality: Target Trial Emulation Studies. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-18 Sheng Nie,Yanqin Li,Yinfang Sun,Shan Chen,Xian Shao,Mingzhen Pang,Shiyu Zhou,Licong Su,Ruixuan Chen,Fan Luo,Xin Xu,Fan Fan Hou,
BACKGROUND Renin-angiotensin system inhibitors (RASi) are widely used among patients with cardiovascular disease, diabetes, and chronic kidney disease, which are high-risk population for AKI. Evidence for the optimal management of RASi during an episode of acute kidney injury (AKI) is lacking. METHODS We conducted a multi-database cohort study using sequential target trial emulation framework from
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Use of eGFR Slope Thresholds as End Point Components in a Kidney Disease Progression Hierarchical Composite End Point. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-17 Niels Jongs,Samvel B Gasparyan,Lars Frison,Patrick Schloemer,Meike Brinker,Dustin J Little,Hiddo J L Heerspink
BACKGROUND We developed and validated a kidney disease progression hierarchical composite end point (HCE) combining time-to-event end points with the rate of estimated glomerular filtration rate (eGFR) decline (eGFR slope) as a continuous end point. An alternative to this continuous end point is to apply various thresholds on an absolute and relative scale for the pairwise comparisons in the eGFR slope
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LARP7 Protects Vascular Smooth Muscle Cell Contractile Phenotype in CKD by Coupling with P300. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-16 Heng Wu,Cailing Su,Ansheng Cong,Ziyu Zhao,Shuang Cui,Chunyi Wu,Zhijie Huang,Yuxin Xie,Zuoyu Hu,Zhanmei Zhou,Lei Zhang,Fan Fan Hou,Wei Cao
BACKGROUND Loss of vascular smooth muscle cell (VSMC) contractile phenotype complicates chronic kidney disease (CKD) and associates with cardiovascular pathologies. Here, focusing on vascular calcification and atherosclerosis, we tested the role of La Ribonucleoprotein 7 (LARP7) in maintaining VSMC contractile phenotype and mitigating CKD-associated vascular pathologies. METHODS Single-cell RNA sequencing
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Acute Cisplatin Nephrotoxicity, Sodium-Glucose Cotransporter 2 Inhibitors, and Benefits Beyond Magnesium. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-16 Chintan V Shah
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Authors' Reply: Acute Cisplatin Nephrotoxicity, Sodium-Glucose Cotransporter 2 Inhibitors, and Benefits Beyond Magnesium. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-16 Weverton M Luchi,James A McCormick,Adriana C C Girardi
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Obesity, Underweight, and Accuracy of eGFR Using Cystatin C and Creatinine in a Northern European Population. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-13 William A Russel,Edouard L Fu,Alessandro Bosi,Aurora Caldinelli,Lesley A Inker,Alex R Chang,Andrew S Levey,Juan J Carrero
BACKGROUND The presence of a low or high body mass index (BMI) in patients may influence the accuracy of estimated glomerular filtration rate (eGFR). This study evaluates the performance of eGFR equations across the range of BMI. METHODS This is an observational study of 4,707 adults (7,503 repeated observations) referred for measured GFR (mGFR) in Stockholm, Sweden. We calculated indexed eGFR (in
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The Quest for a Urea Sorbent: From Frustration, to Failure, to the KidneyX Prize. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-13 Dr Stephen Richard Ash
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Kidney Parameters with Tirzepatide in Obesity with or without Type 2 Diabetes. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-13 Hiddo J L Heerspink,Allon N Friedman,Petter Bjornstad,Daniel H van Raalte,David Cherney,Dachuang Cao,Luis-Emilio Garcia-Pérez,Adam Stefanski,Ibrahim Turfanda,Mathijs C Bunck,Imane Benabbad,Ryan Griffin,Carolina Piras de Oliveira
BACKGROUND Tirzepatide, a once-weekly, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, showed kidney protective effects in people with type 2 diabetes at high cardiovascular disease risk. In this post hoc analysis of the SURMOUNT-1 and SURMOUNT-2 trials, we assessed the association of tirzepatide use with kidney function parameters in people with overweight/obesity
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Detection of Kidney Allograft Rejection Using Urinary Chemokines. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-12 Valentin Goutaudier,Olivier Aubert,Maud Racapé,Agathe Truchot,Marta Sablik,Marc Raynaud,Éric Vicaut,Olivia Rousseau,Michelle Elias,Gillian Divard,Emmanuelle Papuchon,Richard Danger,Béatrice Charreau,Didier Bouton,Thao Nguyen-Khoa,Christine Randoux-Lebrun,Jean-Luc Taupin,Pierre-Antoine Gourraud,Magali Giral,Moglie Le Quintrec,Emmanuel Morelon,Lionel Couzi,Christophe Legendre,Carmen Lefaucheur,Nassim
BACKGROUND Urinary chemokines CXCL9 and CXCL10 have shown promise for detecting kidney allograft rejection, but the demonstration of their added value beyond standard of care patient monitoring requires further study. METHODS We prospectively enrolled adult patients who underwent kidney transplantation in 7 transplant referral centers between July 2018 and December 2019 (ClinicalTrials.gov, NCT03582436)
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Cerebral Blood Flow and Cognition in CKD: A Physiological Paradox. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-10 Aditi Gupta,Swati R Levendovszky
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Real-World Data to Advance Glomerular Disease Care. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-05 Natasha S Freeman,Andrew S Bomback
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Telemedicine for Hemodialysis Care Delivery: Value Added? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-05 Kevin X Shi,Delphine S Tuot
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Targeting B Cells and Plasma Cells in Glomerular Disease. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-04 Syeda Behjat Ahmad,J Ashley Jefferson
Loss of tolerance and the production of self-reactive autoantibodies by the humoral immune system are central to the pathogenesis of many glomerular diseases. These antibodies are produced by plasmablasts and plasma cells, the end-products of B cell lineage development within the bone marrow and secondary lymphoid tissues. In addition to antibody production, B cells also present antigen to T cells
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Isoaspartate Repair of TGF-β Receptor 2: A Novel Checkpoint in Kidney Fibrosis. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-04 Christoph Kuppe
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Exercise and Kidney Function in Care of Older Adults. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-04 Sharlene A Greenwood,Jamie H Macdonald
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Geometric Deep Learning for Multimodal Data in CKD. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-03 Madhumitha Rajagopal,Justin Kauffman,Girish N Nadkarni
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Cdc42 Activation in Anti-nephrin Antibody-Induced Nephropathy. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-03 Ying Zhang,Yoshiyasu Fukusumi,Hidenori Yasuda,Guoqing Chang,Mutsumi Kayaba,Hiroshi Kawachi
BACKGROUND A subset of minimal change nephrotic syndrome was reported to be induced by autoantibodies against nephrin. We have reported that rats injected with murine anti-nephrin antibody showed proteinuria. However, its precise pathogenic mechanisms remain unclear. METHODS The initiation events of podocyte disturbance caused by anti-nephrin antibodies were analyzed using an in vivo rat model and
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Macrophage Accumulation and Cyst Expansion in Pkd2, Ift88, and Double Mutant Mouse Models. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-06-02 Zhang Li,Raksha P Hombal,Jun Wang,Sreelakshmi Cherakara,Timothy C Howton,Kurt A Zimmerman,James F Collawn,Reagan S Andersen,Courtney J Haycraft,Mandy J Croyle,John M Parant,Brittany N Lasseigne,Bradley K Yoder
BACKGROUND Kidney cyst formation occurs due to loss of cilia localized polycystin proteins (e.g., Pkd1 or Pkd2) or ciliary structure (e.g., Ift88 or Kif3a). However, cyst progression is more rapid in polycystin mutant mice compared to cilia mutant mice, and loss of cilia in the polycystin mutant background (e.g., Pkd2 and Kif3a mutation) greatly attenuates cyst development. This led to the proposal
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Questions and Caveats in Antigen-Defined Membranous Nephropathy. J. Am. Soc. Nephrol. (IF 9.4) Pub Date : 2025-05-27 Nicole K Andeen,Vanderlene L Kung,Rupali S Avasare,Sean Barbour,Megan Griffith,Mei Lin Z Bissonnette,Candice Roufosse
Remarkable progress has been made in the discovery of autoantigens in membranous nephropathy. With increasing testing for membranous antigens in daily practice, it is important to consider the varying strength of associations between certain antigens and underlying conditions. This review explores questions and caveats that arise when assessing results of membranous antigen testing. Specifically, we
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mTOR Inhibitors and Vaccine Response in Kidney Transplant Recipients. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-22 Griffith B Perkins,Matthew J Tunbridge,Cheng Sheng Chai,Christopher M Hope,Arthur Eng Lip Yeow,Tania Salehi,Julian Singer,Bree Shi,Makutiro G Masavuli,Zelalem Addis Mekonnen,Pablo Garcia-Valtanen,Svjetlana Kireta,Julie K Johnston,Christopher J Drogemuller,Beatrice Z Sim,Shane M Spencer,Benedetta C Sallustio,Iain Comerford,George Bouras,Daniela Weiskopf,Alessandro Sette,Anupriya Aggarwal,Vanessa Milogiannakis
BACKGROUND Failure to develop protective immunity in response to vaccination is common among kidney transplant recipients, rendering them susceptible to severe infection. Novel strategies are required. Here, we investigated the potential of mechanistic-target-of-rapamycin (mTOR) inhibitors to improve vaccine responses. METHODS Humoral and cellular responses to primary COVID-19 vaccination (ChAdOx1
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Authors' Reply: Expanding the Implications of Proximal Tubular Function Assessment. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-21 Bernardo Rodriguez-Iturbe,Ana Karen Fernández-Yepez,Magdalena Madero
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Expanding the Implications of Proximal Tubular Function Assessment. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-21 Chia-Ter Chao
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Mechanistic Target of Rapamycin Complex 1 in Distal Convoluted Tubule and Renal Potassium Handling. J. Am. Soc. Nephrol. (IF 9.4) Pub Date : 2025-05-21 Yu Xiao,Xin-Peng Duan,Cheng-Biao Zhang,Wen-Hui Wang,Dao-Hong Lin
BACKGROUND Mechanistic-target-of-rapamycin-complex-1 (mTORc1) plays a role in maintaining K + homeostasis. We now examine whether mTORc1 of distal-convoluted-tubule (DCT) regulates Kir4.1/Kir5.1 channels and thiazide-sensitive-Na-Cl cotransporter, which plays a role in regulating renal K + excretion. METHODS We used patch-clamp-technique to examine basolateral Kir4.1/Kir5.1 in early-DCT, immunoblotting
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Voclosporin Overdose-Induced Peroxisomal Structural Changes and AKI Are Prevented By Renal Indole Detoxifier, INMT. J. Am. Soc. Nephrol. (IF 9.4) Pub Date : 2025-05-21 Kazuhiro Hasegawa,Yusuke Sakamaki,Masanori Tamaki,Shu Wakino
BACKGROUND The novel calcineurin inhibitor (CNI) voclosporin is effective in treating lupus nephritis but has been associated with acute kidney injury (AKI) through largely unknown mechanisms. Voclosporin-induced AKI revealed that voclosporin reduces the expression of indolethylamine N-methyltransferase (Inmt), an enzyme responsible for detoxifying local uremic toxins such as indole. This study investigates
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Hypercalcemia's Hidden Regulator: Calcium-Sensing Receptor and the Kidney's Secret Weapon J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-15 Jessica Paola Bahena-López, Gerardo Gamba
An abstract is unavailable.
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Evidence-Based Guidance for Strategies for Blood Transfusion with CKD and Myocardial Infarction J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-13 Michelle M.Y. Wong, Charles A. Herzog
An abstract is unavailable.
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Safety and Efficacy of Vadadustat for the Treatment of CKD-Related Anemia within and outside the United States. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-13 Glenn M Chertow,Kai-Uwe Eckardt,Mark J Sarnak,Wolfgang C Winkelmayer,Rajiv Agarwal,Todd Minga,Wenli Luo,Steven K Burke
BACKGROUND Vadadustat's global clinical program was comprised of four noninferiority trials comparing vadadustat and darbepoetin alfa for CKD-related anemia: two in dialysis-dependent (DD)-CKD and two in non-dialysis-dependent (NDD)-CKD. While vadadustat met prespecified noninferiority criteria for hematological efficacy globally, it did not meet noninferiority criteria for cardiovascular safety in
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Authors' Reply: Acetazolamide and Renal Hemodynamics: Interplay between Tubuloglomerular Feedback and Renin-Angiotensin-Aldosterone System Adaptation. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-12 Charles Ginsberg,Jeremy Pettus,Joachim H Ix
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Authors' Reply: Concerns about Hospitalization on Cystatin C- and Creatinine-Based eGFR. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-08 Ian E McCoy,Chi-Yuan Hsu
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Engineered Neuromedin U Promotes Type 2 Innate Immunity and Renoprotection in Acute Kidney Injury. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-08 Sara Trindade-Correia,Vasco Correia,Filipe Delgado,Marta Baptista,Inês Amendoeira Cabral,Tânia Carvalho,Luana Macedo,Margarida Nunes,Pedro Z Andrade,Filipa Cardoso,Julie Chesné,David F Braga Malta,Covadonga Pañeda,Henrique Veiga-Fernandes,Vânia Cardoso
BACKGROUND Acute kidney injury (AKI) is a severe condition leading to the sudden loss of kidney function. Activation of type 2 innate lymphoid cells (ILC2s) by neuromedin U (NMU) is highly selective and key in controlling mucosal tissue repair and homeostasis. Renal ILC2s are associated with renoprotective effects in AKI. Here, we explored the therapeutic potential of an engineered NMU analogue (LIMM102)
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Concerns about Hospitalization on Cystatin C- and Creatinine-Based eGFR. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-08 Shiwei Yang,Xianhai Zhao,Linghua Wang,Guang Zhang
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American Society of Nephrology Presidential Address: #RedefiningTheStandard: Adapted from Kidney Week 2024 President's Address J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-07 Deidra C. Crews
An abstract is unavailable.
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Pediatric Nephrology at a Crossroads: Workforce Challenges to Ensure Access to Kidney Disease Care J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-07 Leonela Villegas, Zubin J. Modi
An abstract is unavailable.
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Profibrotic MAIT17 Cells in Peritoneal Fibrosis: A New Kid on the Block? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-07 Jing Liu, Simon Davies, Jing O. Wu
An abstract is unavailable.
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Histologic Features Associated with Kidney Survival in Scleroderma Renal Crisis. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-07 Yannick Binois,David Buob,Marie-Sophie Meuleman,Idris Boudhabhay,Pierre Isnard,Marion Rabant,Viviane Gnemmi,Laurent Daniel,Isabelle Brocheriou,Clement Gosset,Marie Frimat,Thomas Quémeneur,Rafik Mesbah,Noemie Jourde-Chiche,Olivier Moranne,Pierre Housset,Emmanuel Esteve,Alexis Mathian,Sebastien Rivière,Aurélie Hummel,Luc Mouthon,Benjamin Chaigne,Anne Lyse Langlois,Eric Thervet,Olivier Aubert,Lubka Roumenina
BACKGROUND Scleroderma renal crisis is a severe complication of systemic sclerosis that is associated with higher morbidity and mortality. However, limited data are currently available regarding the factors affecting renal outcome during scleroderma renal crisis. The objective of this study is to describe renal histopathology in scleroderma renal crisis and to evaluate its association with kidney failure
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Fortifying the Diabetic Kidney Disease Treatment Armamentarium: Multitarget Senotherapeutic and Regenerative Strategies. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-07 Helly A Patel,Jiaxuan Wang,Caroline J Zinn,Maya Learmonth,Lilach O Lerman,Joy Wolfram,LaTonya J Hickson
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Antineutrophil Cytoplasmic Antibodies (ANCAs): Role in Diagnosis, Disease Monitoring, and Prognosis. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-07 Nicole E Wyatt,Vimal K Derebail,Ronald J Falk,Koyal Jain
ANCA-associated vasculitis (AAV) is a rare and potentially fatal autoimmune disorder characterized by pauci-immune necrotizing vasculitis affecting small- to medium-sized blood vessels. The pathogenic role of ANCAs in AAV is supported by both clinical and experimental evidence, and when used in the proper clinical setting, ANCA testing is highly specific for AAV. Testing with both indirect immunofluorescence
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Variation of eGFR Wait Time Modifications for Black Kidney Transplant Candidates in the United States. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-06 Jesse D Schold,Susana Arrigain,S Ali Husain,Miko Yu,Rocio Lopez,Deena Brosi,Ryan LaVanchy,Sumit Mohan
BACKGROUND In 2023, kidney transplant programs in the United States were mandated by the Organ Procurement and Transplantation Network (OPTN) to identify all Black candidates on their kidney waiting lists and evaluate potential modifications of waiting time. This mandate was the result of established differences in eligibility for candidates to receive priority for donor offers based on race-neutral
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Rapid and Simultaneous Initiation of Guideline-Directed Kidney Therapies in Patients with CKD and Type 2 Diabetes. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-06 Ahmed Mustafa Rashid,Muhammad Shahzeb Khan,David Z I Cherney,Ankit Mehta,Janani Rangaswami,Tariq Shafi,Javed Butler
The global incidence of CKD continues to rise, with type 2 diabetes as a major contributor. At any stage of CKD, patients with concurrent CKD and type 2 diabetes are at heightened cardiovascular risk and have a greater likelihood of dying from cardiovascular causes than progressing to kidney failure. Consequently, the use of "four pillars" of CKD therapy, including renin-angiotensin system inhibitors
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Krüppel-Like Factor 6 Induces RNA Polymerase II Subunit RPB1 to Promote Kidney Injury. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-06 Sian E Piret,Samaneh DiMartino,Maanasa Hanubal,Merin Davis,Jiakang Wang,Tej Bahadur,Asha Rath,Nehaben A Gujarati,Bismark O Frimpong,Robert Bronstein,Monica P Revelo,Yiqing Guo,Sandeep K Mallipattu
BACKGROUND Initial proximal tubule cell injury and dedifferentiation contribute to acute kidney injury (AKI), and persistent dedifferentiation drives fibrosis and chronic kidney disease (CKD). Proximal tubule-specific knockdown of zinc-finger transcription factor Krüppel-like factor 6 (Klf6) attenuates the AKI to CKD transition. Our aim was to study the early transcriptional mechanisms by which KLF6
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Impact of Hematopoietic CD14 on Oxidative Stress during Salt-Sensitive Hypertension and Kidney Injury. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-06 Emily C Burns-Ray,John Henry Dasinger,Mary Cherian-Shaw,Samuel D Walton,Kaitlyn E Baldwin,Ann B Cormier,Sadaf Hasan,Daniel J Fehrenbach,Justine M Abais-Battad,David L Mattson
BACKGROUND In high-salt diet-fed Dahl salt-sensitive rats, increased CD14 expression by infiltrating macrophages accompanies hypertension and kidney damage. Interestingly, genetic deletion of CD14 in the Dahl salt-sensitive rat model (SSCD14-/-) conferred a significant exacerbation of salt-induced hypertension and associated kidney disease in females. We speculated that CD14 may function to modulate
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Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-05-05 Joanne B Cole,Emma H Dahlström,Damian Fermin,Yogesh Gupta,Claire Hill,Laura J Smyth,Hongbo Liu,Raymond J Kreienkamp,Marcus G Pezzolesi,Jing Jing Cao,Erkka Valo,Wei-Min Chen,Suna Onengut-Gumuscu,Stephen S Rich,Eoin P Brennan,Darrell Andrews,Ciarán Kennedy,Harvest F Gu,Lars Stechemesser,Raimund Weitgasser,Jelizaveta Sokolovska,Lina Radzeviciene,Rasa Verkauskiene,Nicolae M Panduru,Peter Rossing,Tarunveer
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Use of Intravenous Albumin in Nephrology Practice Should Be Guideline-Based. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-30 Emma K Ullrich,Jeannie Callum,Edward G Clark
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Addressing Disparities in ESKD Care: Insights from a Multicultural European Cohort J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-21 Lucas Jacobs, Maria do Carmo Filomena Mesquita, Joëlle Nortier, Frédéric Collart
An abstract is unavailable.
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Authors' Reply: Addressing Disparities in ESKD Care: Insights from a Multicultural European Cohort J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-21 Ashutosh M. Shukla, Yi Guo, Rebecca Campbell-Montalvo, Serena Jingchuan Guo
An abstract is unavailable.
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GIT ArfGAP2: A Cytoskeletal Safeguard in Podocytes: Suppressing Rac1 to Combat Glomerular Injury J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-18 Shuta Ishibe, Xuefei Tian
An abstract is unavailable.
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Network Interactions of Circulating FGF23, HRG-HMGB1, and Cardiac Disease in CKD. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-16 Farzana Perwad,Elvis A Akwo,Arushi Singhal,Nicholas Vartanian,Larry J Suva,Peter A Friedman,Cassianne Robinson-Cohen
BACKGROUND Genome-wide association studies (GWAS) have identified numerous genetic loci associated with mineral metabolism markers but have exclusively focused on single-trait analysis. In this study, we performed a multi-trait analysis of GWAS (MTAG) of mineral metabolism, exploring overlapping genetic architecture between traits to identify novel genetic associations for fibroblast growth factor
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Xenotransplantation: Current Understanding of the Mechanism of Immune-Mediated Injury. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-16 Vasishta S Tatapudi,Aprajita Mattoo,Tamar Schiff,Sapna A Mehta,Edward Y Skolnik,Robert A Montgomery
The scarcity of transplantable organs represents a worldwide public health crisis, and as a result, thousands of people with kidney failure die waiting for a transplant each year. Xenotransplantation involves transplanting organs from an animal source into humans, offering a potential solution to this significant unmet need. Indeed, if there is a limitless supply of organs, many more patients who do
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Long-Term Outcomes in Nephrotic Syndrome by Kidney Biopsy Diagnosis and Proteinuria. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-17 David Pitcher,Fiona Braddon,Bruce Hendry,Alex Mercer,Jonathan Barratt,Retha Steenkamp,Katie Wong,A Neil Turner,Wu Gong,Daniel P Gale,Moin A Saleem
BACKGROUND The UK Registry of Rare Kidney Diseases (RaDaR) Idiopathic Nephrotic Syndrome cohort includes adults and children with genetic nephrotic syndrome, Focal Segmental Glomerulosclerosis (FSGS) and minimal change disease. This study examines long-term patient outcomes as a function of kidney biopsy diagnosis and proteinuria control. METHODS 2467 adults and 1599 children were followed to establish
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Deciphering Clonal Hematopoiesis of Indeterminate Potential: Methods, Mechanisms, and Implications for Kidney Diseases. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-15 Zhi Yu,Caitlyn Vlasschaert,Pradeep Natarajan
CKD afflicts over 10% of US adults, with its prevalence increasing sharply with age. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, genetically heterogeneous blood cell disorder characterized by the age-related clonal expansion of hematopoietic cells driven by leukemogenic somatic mutations yet without hematologic malignancy or dysplasia. While CHIP is a strong risk factor of future
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Effect of Peer Mentorship on Hospitalizations among Patients Receiving Maintenance Hemodialysis: A Pragmatic Randomized Controlled Trial. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-15 Ladan Golestaneh,Ryung S Kim,Christopher Roach,Keith C Norris,Aaron D Fox,Michal L Melamed,Kerri L Cavanaugh
BACKGROUND Patients receiving maintenance hemodialysis are hospitalized frequently, leading to disproportionate cost of care, and contributing to high morbidity and mortality. METHODS To test the effectiveness of peer mentorship to reduce hospitalization rates among patients receiving hemodialysis we performed a multi-center, pragmatic, randomized, controlled trial. Two hundred patient participants
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Correction: The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-11 Michael Ignarski,Constantin Rill,Rainer W J Kaiser,Madlen Kaldirim,René Neuhaus,Reza Esmaillie,Xinping Li,Corinna Klein,Katrin Bohl,Maike Petersen,Christian K Frese,Martin Höhne,Ilian Atanassov,Markus M Rinschen,Katja Höpker,Bernhard Schermer,Thomas Benzing,Christoph Dieterich,Francesca Fabretti,Roman-Ulrich Müller
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Correction: The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-11 Marc Johnsen,Torsten Kubacki,Assa Yeroslaviz,Martin Richard Späth,Jannis Mörsdorf,Heike Göbel,Katrin Bohl,Michael Ignarski,Caroline Meharg,Bianca Habermann,Janine Altmüller,Andreas Beyer,Thomas Benzing,Bernhard Schermer,Volker Burst,Roman-Ulrich Müller
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IGF-Binding Protein 7 and Cadmium-Induced Hepatorenal Fibrosis. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-10 Shuai-Shuai Xie,Rui Hou,Li Gao,Qin Yang,Wei Li,Ze-Hui Dong,Yu-Hang Dong,Shuang-Jian Li,Wen-Xian Ma,Ying-Ying Gao,Long Xu,Chao Li,Ying Chen,Ju-Tao Yu,Jia-Nan Wang,Ming-Lu Ji,Ruo-Bing He,Xiao-Guo Suo,Ming-Ming Liu,Juan Jin,Jia-Gen Wen,Chen Yang,Xiao-Ming Meng
BACKGROUND Chronic cadmium exposure can induce the onset and progression of hepatorenal fibrosis; however, its molecular basis is unclear. Insulin-like growth factor-binding protein 7 (IGFBP7) is not only a biomarker of acute kidney injury (AKI), but also plays a functional role in promoting kidney injury and inflammation. Abnormal repair of AKI causes kidney fibrosis and chronic kidney disease. IGFBP7
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Association of Clonal Hematopoiesis of Indeterminate Potential with Cardiovascular Events in Patients with CKD. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-04-09 Yang Pan,Caitlyn Vlasschaert,Varun Rao,Elvis A Akwo,James E Hixson,Mesbah Uddin,Zhi Yu,Do-Kyun Kim,Alexander Bick,Bryan Kestenbaum,Michael Chong,Guillaume Paré,Michael Rauh,Adeera Levin,James P Lash,Manjula Kurella Tamura,Debbie L Cohen,Jiang He,Lee Hamm,Rajat Deo,Zeenat Bhat,Panduranga Rao,Dawei Xie,Pradeep Natarajan,Tanika N Kelly,Cassianne Robinson-Cohen,Matthew B Lanktree,
BACKGROUND Patients with CKD are at higher risk of cardiovascular disease. Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with cardiovascular disease in the general population, with a causal role observed in animal models. In the general population, the effect of CHIP is greater for somatic mutations in pre-defined CHIP driver genes other than DNMT3A (referred to as non-DNMT3A
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