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Identification of a translatable animal model for dry eye disease using comparative analysis of tear proteins across species Ocul. Surf. (IF 5.9) Pub Date : 2025-05-07 Mayelín Pérez-Perdomo, Ana González-López, Laura Ortega-Llamas, David Alba-Molina, Mario Blanco-Blanco, María del Mar Granados, Adrián Guerrero-Moreno, Stephen Carl Pflugfelder, Christoph Ullmer, Sascha Fauser, Yolanda Jiménez-Gómez, Miguel González-Andrades
This study aimed to assess the similarity of tear proteins between experimental animals and humans to identify the most translational animal model for dry eye disease (DED).
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Use of a transgenic mouse model for in vivo monitoring of corneal pathologies following Sulfur Mustard Exposure Ocul. Surf. (IF 5.9) Pub Date : 2025-04-24 Ariel Gore, Rahav Efrati, Shelly Atanelov, Pnina Glick, Maayan Cohen, Hila Gutman, Relli Gez, Vered Horwitz
The dynamic course of sulfur mustard (SM)-induced ocular insult involves an acute phase, which may progress to a chronic phase or a quiescent period, followed by late pathology. Visualizing pathological corneal changes in vivo could enhance understanding of this process and aid treatment development.
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Dessicating stress triggers and exacerbates experimental ocular Graft-versus-host-disease Ocul. Surf. (IF 5.9) Pub Date : 2025-04-24 Uta Gehlsen, Martina Maass, Daniela Stary, Svenja Wagener-Ryczek, Gwen Musial, Manolis Pasparakis, Cintia S. de Paiva, Michael E. Stern, Philipp Steven
Chronic ocular graft-versus-host disease (oGVHD) is one of the most common complications after allogeneic hematopoietic stem cell transplantation (aHSCT). Recent studies indicate that desiccating stress by air-conditioning in transplantation wards increases the incidence of oGVHD. To test the hypothesis that experimental desiccating stress is a risk factor for oGVHD a mouse model of oGVHD was subjected
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Ocular graft-versus-host disease: Experience, incidence, and treatment outcomes at a university-based tertiary care ophthalmology center Ocul. Surf. (IF 5.9) Pub Date : 2025-04-11 Zeenal G. Dabre, Tanya Sheth, Elias Hernandez, Jessica Mun, Diana Hernandez, Nancy Ascencio, Christian Kim, Monazzah Sarwar, Kiera Byrne, Anubhav Pradeep, Damiano Rondelli, Christine Mun, Sandeep Jain
This study describes the clinical experience, incidence, and outcomes of treating chronic ocular graft-versus-host disease (oGVHD) at a tertiary care ophthalmology center.
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Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33–46 Ocul. Surf. (IF 5.9) Pub Date : 2025-04-11 Jacqueline Tan
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Pipeline: Therapeutics – Two views of off-label use Ocul. Surf. (IF 5.9) Pub Date : 2025-04-10 Gary D. Novack
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Expert consensus on pediatric dry eye: Insights from a European Delphi study Ocul. Surf. (IF 5.9) Pub Date : 2025-04-05 Edoardo Villani, Paolo Nucci, Jose Manuel Benitez-del-Castillo, Annegret Dahlmann-Noor, Wolf Alexander Lagrèze, Dominique Bremond-Gignac, PeDED Delphi Group
Dry Eye Disease (DED) is a symptomatic multifactorial condition of the ocular surface, primarily characterized by tear film instability, which can lead to ocular surface damage. While traditionally associated with adults, recent studies have shown a significant prevalence of DED in pediatric populations, exacerbated by modern lifestyle changes such as increased screen time and environmental factors
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Prevalence and antimicrobial susceptibility pattern of coagulase-negative Staphylococci isolated from ocular infections: A systematic review and meta-analysis Ocul. Surf. (IF 5.9) Pub Date : 2025-04-04 Abolfazl Rafati Zomorodi, Maryam Mohammadi, Zahra Gholizadeh Farshi, Mohammad Hassan Parvizi Mashhadi, Sasan Pourbagher Benam, Mohammad Motamedifar
Bacteria are the leading cause of ocular infections (OIs), accounting for 32 %–74 % of cases globally. Coagulase-negative Staphylococci (CoNS) are frequently identified as the main causative pathogens of all types of OIs. This study systematically reviewed the prevalence of CoNS and their resistance rates to ciprofloxacin, chloramphenicol, tetracycline, and trimethoprim/sulfamethoxazole in OIs worldwide
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Pard3 promotes corneal epithelial stratification and homeostasis by regulating apical-basal polarity, cytoskeletal organization and tight junction-mediated barrier function Ocul. Surf. (IF 5.9) Pub Date : 2025-04-04 Mehak Vohra, Simran Kumar, Peri Sohnen, Satinder Kaur, Sudha Swamynathan, Tomonori Hirose, Zbynek Kozmik, Shivalingappa K. Swamynathan
To document the expression of apical-basal polarity (ABP) determinants in the mouse corneal epithelium (CE) and elucidate the functions of Pard3 in establishment and maintenance of ABP, stratification, homeostasis, and barrier function in the CE.
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A tribute to Gary N. Foulks, M.D. (1944–2025) and his contributions to the ocular surface Ocul. Surf. (IF 5.9) Pub Date : 2025-04-02 Michael H. Goldstein, Deepinder Dhaliwal, Ed Isbey, Stephen Pflugfelder, Mark J. Mannis, Gary D. Novack
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Corneal epithelial cells upregulate macropinocytosis to engulf metabolically active axonal mitochondria released by injured axons Ocul. Surf. (IF 5.9) Pub Date : 2025-04-01 Sonali Pal-Ghosh, Himani Datta-Majumdar, Soneha Datta, Shelly Dimri, Jordan Hally, Hugo Wehmeyer, Zhong Chen, Mitchell Watsky, Jian-Xing Ma, Wentao Liang, Mary Ann Stepp
To determine the mechanisms used to internalize mitochondria by corneal epithelial cells after in vivo corneal trephine injury and in vitro in corneal epithelial cells.
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The association between personality and dry eye disease: A large cross-sectional study Ocul. Surf. (IF 5.9) Pub Date : 2025-03-26 Morten S. Magno, Laura E. Wolpert, Mathias K. Morthen, Tor P. Utheim, Christopher J. Hammond, Jelle Vehof
Personality influences health and wellbeing. The purpose of this large, cross-sectional study was to clarify the association between personality traits and dry eye disease (DED).
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Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery Ocul. Surf. (IF 5.9) Pub Date : 2025-03-25 Milad Abbasi, Hossein Aghamollaei, Ahmad Vaez, Ali Mohammad Amani, Hesam Kamyab, Shreeshivadasan Chelliapan, Sajad Jamalpour, Renato Zambrano-Dávila
The distinctive benefits and drawbacks of various drug delivery strategies to supply corneal tissue improvement for sense organs have been the attention of studies worldwide in recent decades. Static and dynamic barriers of ocular tissue prevent foreign chemicals from entering and inhibit the active absorption of therapeutic medicines. The distribution of different medications to ocular tissue is one
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Endoplasmic reticulum stress contributes to the development of ocular graft-vs-host disease in the eyelids and the ocular surface Ocul. Surf. (IF 5.9) Pub Date : 2025-03-22 Shinri Sato, Yoko Ogawa, Eisuke Shimizu, Kazuki Asai, Kazuno Negishi, Kazuo Tsubota, Masatoshi Hirayama
While endoplasmic reticulum (ER) stress has been implicated in various aspects of graft-versus-host disease (GVHD), its effects on the eyelids and ocular surface in patients with chronic GVHD (cGVHD) remains poorly understood. We aimed to investigate the relationship between ER stress and ocular GVHD using the ER stress suppressor, 4-phenylbutyric acid (PBA).
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Smoking negatively impacts ocular surface health and corneal nerve metrics Ocul. Surf. (IF 5.9) Pub Date : 2025-03-13 Ansa Anam, Mingyi Yu, Chang Liu, Isabelle Xin Yu Lee, Juanita Yang, A.V. Shanmathi, Ching-Yu Cheng, Yu-Chi Liu
To evaluate the effects of smoking on ocular surface through comprehensive analysis of corneal nerves, corneal epithelium, dendritic cells (DCs), and clinical assessments.
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A masked study to differentiate in vivo confocal microscopic features of Pythium insidiosum and fungal filaments Ocul. Surf. (IF 5.9) Pub Date : 2025-03-12 Bhupesh Bagga, Md Hasnat Ali, K Shreeya Jain, Tanmay Gokhale, Joveeta Joseph, Pabitra Duwal, Amrita Mohanty, Lakshminarayanan Gowtham, Savitri Sharma
To describe in vivo confocal microscopic features of Pythium insidiosum in patients with Pythium keratitis and compare with those observed in fungal keratitis.
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Readership awareness series – Paper 15: How the ICMJE 2025 recommendations update impact the scientific community? Ocul. Surf. (IF 5.9) Pub Date : 2025-03-04 Mohammad Javed Ali MD PhD FRCS, Ali Djalilian MD
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Essential roles of sensory nerve in maintenance of cornea-phenotype in mice Ocul. Surf. (IF 5.9) Pub Date : 2025-03-01 Yuka Okada, Takayoshi Sumioka, Hiroki Iwanishi, Shingo Yasuda, Jianhua Zhang, Yong Yuan, Chia-Yang Liu, Winston Whei-Yang Kao, Shizuya Saika
To the best of our knowledge, no reports have been published on the long-term changes in corneal tissue during the course of neuroparalytic keratopathy caused by destruction of the ophthalmic nerve in experimental animals. To bridge this research gap, we investigated the histopathology of the cornea in mice 3, 12, and 24 months after coagulation of the ophthalmic nerve.
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Topical low-dose heparin in ocular Stevens Johnson Syndrome and associated molecular correlations: A randomized controlled pilot study Ocul. Surf. (IF 5.9) Pub Date : 2025-02-28 Renu Venugopal, Shivam Sharma, Lata Singh, Seema Sen, Thirumurthy Velpandian, Prafulla Kumar Maharana, Seema Kashyap, Sandeep Jain, Namrata Sharma
To elucidate the efficacy of topical low dose heparin (LDH) as an adjuvant therapy in of sub -chronic and chronic ocular Stevens-Johnson Syndrome (SJS) and its effect on Neutrophil extracellular traps (NETs) associated markers.
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Decoding the corneal immune microenvironment in healthy and diabetic mice during corneal wound healing Ocul. Surf. (IF 5.9) Pub Date : 2025-02-27 Yujing Lin, Xiaowen Zhang, Di Sun, Qun Wang, Shengqian Dou, Qingjun Zhou
Diabetic keratopathy (DK) is an underdiagnosed ocular complication of diabetes mellitus. The changes of ocular immune microenvironment contribute to the pathogenesis of DK, while precise mechanisms remain inadequately understood. Here, we employed single-cell RNA sequencing (scRNA-seq) to elucidate the transcriptional alterations of immune cells from diabetic and healthy control mouse corneas during
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A prospective, longitudinal study to assess progression of ocular surface signs, tear cytokines and protein profiles in young adults Ocul. Surf. (IF 5.9) Pub Date : 2025-02-25 Rachel K. Casemore, James S. Wolffsohn, Tor Paaske Utheim, Sjur Reppe, Hans Christian D. Aass, Debarun Dutta
To compare ocular surface characteristics, tear protein profiles, and cytokines in young adults with and without evaporative dry eye disease (DED), exploring any associations with lifestyle factors, and determine any progression after one year.
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Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis Ocul. Surf. (IF 5.9) Pub Date : 2025-02-21 Antonio Ballesteros-Sánchez, Carlos Rocha-de-Lossada, José-María Sánchez-González
To investigate the efficacy of eyelid warming devices as first-step treatment in patients with meibomian gland dysfunction (MGD).
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The impact of dry eye disease on patient-reported quality of life: A Save Sight Dry Eye Registry study Ocul. Surf. (IF 5.9) Pub Date : 2025-02-13 Himal Kandel, Fiona Stapleton AO, Laura E. Downie, Ngozi C Chidi‐Egboka, David MIngo-Botin, Francisco Arnalich-Montiel, Saaeha Rauz, Alberto Recchioni, Sanjeeta Sitaula, Maria Markoulli, Vincent Daien, Fanny Babeau, Gerd Geerling, Jennifer P. Craig, Stephanie L. Watson OAM
The aim of this real-world registry study was to evaluate the quality-of-life (QoL) impact of dry eye disease (DED). The specific objectives were to determine factors affecting QoL in DED, and to evaluate the psychometric properties of the Ocular Surface Disease Index (OSDI), Ocular Comfort Index (OCI), and Patient Health Questionnaire (PHQ) in a real-world DED population using modern psychometric
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Impact of botulinum toxin type A on ocular pain with neuropathic features Ocul. Surf. (IF 5.9) Pub Date : 2025-02-12 Elyana V.T. Locatelli, Jaxon J. Huang, Jason D. Betz, Jordan J. Huang, Nicole B. Kantor, Nicholas Reyes, Elizabeth R. Felix, Wendy W. Lee, Anat Galor
To investigate the impact of botulinum toxin type A (BoNT-A) on neuropathic/nociplastic ocular pain (NOP) and identify predictors of patient outcomes.
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Assessment of the clonal growth potential of meibomian gland stem/progenitor cells via clonal analysis Ocul. Surf. (IF 5.9) Pub Date : 2025-02-12 Yuli Guo, Rongrong Zhang, Minjie Zhang, Sai Luo, Wansui Li, Le Sun, Meiqin Zhong, Zuguo Liu, Yang Wu, Wei Li, Jinghua Bu
Clonal analysis is a feasible method to evaluate the status of stem/progenitor cells in epidermal or limbus investigations. This study aimed to evaluate the clonal growth potential of meibomian gland (MG) epithelial cells using clonal analysis.
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Alleviative effect of probiotics and prebiotics on dry eye in type 2 diabetic mice through the gut-eye axis Ocul. Surf. (IF 5.9) Pub Date : 2025-02-06 Shirui Dai, Jianfeng Long, Wentao Han, Liwei Zhang, Baihua Chen
Diabetes Mellitus (DM) is a metabolic disease that manifests as a state of “chronic low-grade inflammation”. Patients with DM have a disorder of intestinal flora. There is a discernible correlation between this disorder of intestinal flora and the onset and progression of eye diseases, which offers novel insights into treating eye diseases through the modulation of intestinal flora. Here, we demonstrated
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Effects of blinking exercises on palpebral fissure height and tear film parameters Ocul. Surf. (IF 5.9) Pub Date : 2025-02-05 Reiko Arita, Shima Fukuoka, Ray Matsumoto, Minako Kaido
Blinking is an involuntary movement essential for ocular surface health and visual comfort. While blinking exercises in patients with dry eye have been shown to improve symptoms, increase non-invasive tear film breakup time (NIBUT), and decrease incomplete blink rate (IBR), no studies have quantified improvements in eyelid opening. This study evaluated the effects of blinking exercises on palpebral
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Development and optimization of an ex vivo model of corneal epithelium damage with 1-heptanol: Investigating the influence of donor clinical parameters and MSC-sEV treatment on healing capacity Ocul. Surf. (IF 5.9) Pub Date : 2025-02-04 Filippo Bonelli, Seyedmohammad Moosavizadeh, Elisa Fasolo, Alessia Di Nella, Vanessa Barbaro, Ilaria Zorzi, Mauro Krampera, Jana D'Amato Tóthová, Diego Ponzin, Thomas Ritter, Stefano Ferrari, Umberto Rodella
To develop and characterize a reproducible human corneal epithelial wound-healing model using 1-heptanol, and to investigate the healing potential of Bone Marrow-derived Mesenchymal Stromal Cell small Extracellular Vesicles (MSC-sEV) and the influence of donor characteristics on epithelial healing.
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Pipeline: US FDA efficacy requirements for treatment of ocular surface disease: Drugs vs. medical devices Ocul. Surf. (IF 5.9) Pub Date : 2025-02-04 R.Lee Kramm, Gary D. Novack
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Effect of hematopoietic stem cell transplantation on meibomian gland structure Ocul. Surf. (IF 5.9) Pub Date : 2025-01-31 Andrea Novo-Diez, Jens Horstmann, Itziar Fernández, Margarita Calonge, María J. González-García, Philipp Steven
To assess morphological changes in the meibomian glands (MGs) pre- and post-hematopoietic stem cell transplantation (HSCT).
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Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1 Ocul. Surf. (IF 5.9) Pub Date : 2025-01-31 Yong Yuan, Shingo Yasuda, Kaitlyn L. Funk, Winston Kao, Shizuya Saika, Adam Kaufman, Chia-Yang Liu
To understand how Tbr1 and Smad4 play a pivotal role in controlling ECM synthesis versus degradation for maintaining corneal stromal homeostasis and otherwise leading to corneal ectasia.
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The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study Ocul. Surf. (IF 5.9) Pub Date : 2025-01-31 Fiona Stapleton, Tianni Jia, Venita DePuy, Charles Bosworth, Marc Gleeson, Jacqueline Tan
To explore effects of topical 1 % selenium sulfide on signs and symptoms in symptomatic contact lens-wearers, in an exploratory 4-month prospective placebo-controlled double-masked randomised trial.
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A large hypothesis-free proteomics study investigating serum inflammatory markers as biomarkers of dry eye disease Ocul. Surf. (IF 5.9) Pub Date : 2025-01-28 Jelle Vehof, Amber Rhee, Niccolò Rossi, Mario Falchi, Christopher J. Hammond, Frances M.K. Williams
To test the association between serum inflammatory markers and dry eye disease (DED) using a hypothesis-free proteomic approach in a population-based cohort.
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Application of stem cell-derived exosomes in anterior segment eye diseases: A comprehensive update review Ocul. Surf. (IF 5.9) Pub Date : 2025-01-28 Masoud Khorrami-Nejad, Hesam Hashemian, Ali Majdi, Khosrow Jadidi, Hossein Aghamollaei, Ali Hadi
Mesenchymal stem cell (MSC) therapy has emerged as a promising approach for addressing various eye-related conditions. Yet, its clinical application faces challenges due to issues such as limited biocompatibility and difficulties in effectively delivering treatment to specific ocular tissues. Recent studies have shifted attention towards MSC-derived exosomes, which share similar regenerative, reparative
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Label-free quantitative imaging of conjunctival goblet cells Ocul. Surf. (IF 5.9) Pub Date : 2025-01-23 Noseong Park, Suil Jeon, Seonghan Kim, Jungbin Lee, Jin Suk Ryu, Wan Jae Choi, Chang Ho Yoon, Chulmin Joo, Ki Hean Kim
To introduce and validate quantitative oblique back-illumination microscopy (qOBM) as a label-free, high-contrast imaging technique for visualizing conjunctival goblet cells (GCs) and assessing their functional changes.
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Relative importance of tear homeostatic signs for the diagnosis of dry eye disease Ocul. Surf. (IF 5.9) Pub Date : 2025-01-21 James S. Wolffsohn, Sònia Travé-Huarte, Fiona Stapleton, Laura E. Downie, Marc-Matthias Schulze, Sarah Guthrie, Ulrike Stahl, Michael T.M. Wang, Jennifer P. Craig
Disease misdiagnosis is more likely if standardised diagnostic criteria are not used. This study systematically examined the effect on diagnosing dry eye disease (DED), when tests for evaluating tear film homeostasis were included or excluded from a multi-test protocol.
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Spatial transcriptomics and single-cell RNA-sequencing revealed dendritic cell-mediated inflammation in keratoconus Ocul. Surf. (IF 5.9) Pub Date : 2025-01-19 Shiqi Luo, Jingying Li, Yan Yang, Yang Jiang, Ying Jie, Wei Ge
Keratoconus (KC) is a corneal disorder characterized by central corneal protrusion and thinning. In this study, spatial transcriptomics was employed to investigate molecular and cellular variations in KC, revealing a distinct pattern of inflammatory responses across the cornea. Upregulation of inflammatory processes was observed in the central cornea, while downregulation was noted in the periphery
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Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium Ocul. Surf. (IF 5.9) Pub Date : 2025-01-18 Lili Lian, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Jiahe Wang, Letong Chen, Peter S. Reinach, Xiaoyin Ma, Wei Chen, Qinxiang Zheng
The activation of the NLRP3 inflammasome by hyperosmotic stress is a critical pathophysiological response in dry eye disease (DED), driving the chronic cycle of inflammation on the ocular surface. The specific mechanism underlying hyperosmotic mechanical stimulation activates the NLRP3 inflammasome remains unclear. This study provides evidence that PIEZO1, a mechanosensitive ion channel, functions
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A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals Ocul. Surf. (IF 5.9) Pub Date : 2025-01-17 Ling Li, Xinhao Zhu, Weihao Xu, Mali Dai, Zihao Liu, Yanxiao Li, Yiting Fang, Jinyang Li, Wei Chen
To assess the impact of prolonged and intense exposure to video display terminals (VDTs) on ocular surface homeostasis.
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Prevalence of dry eye disease in Spain: A population-based survey (PrevEOS) Ocul. Surf. (IF 5.9) Pub Date : 2025-01-17 José M. Benítez-del-Castillo, Bárbara Burgos-Blasco
To determine the countrywide prevalence of dry eye disease (DED) at the population level in Spain, and associated risks.
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A novel Schirmer strip-based tear matrix metalloproteinase measurement in dry eye evaluation Ocul. Surf. (IF 5.9) Pub Date : 2025-01-15 Di Chen, Wubi Li, Shan Yang, Hang Song, Yu Di, Weixing Zhong, Miao Zhang, Qin Long, Ying Li, Chan Zhao
The diagnosis and evaluation of dry eye require easy-to-use, precise, and consistent tools in clinical setting. Matrix metalloproteinase 9 (MMP-9) has been proven to be a reliable indicator of dry eye inflammation. The aim of this study is to establish an Eu-time resolved fluorescence immunochromatography (Eu-TRFICO) method for quantitative detection of MMP-9 in human tear based upon widely used Schirmer
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Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease Ocul. Surf. (IF 5.9) Pub Date : 2025-01-10 Xin Chen, Na Lin, Haixia Liu, Jing Lin, Ning Gao, Zhao Liu, Cintia S. de Paiva, Stephen C. Pflugfelder, De-Quan Li
To explore the destructive and protective effects and therapeutic targets of IL-36 cytokines in dry eye disease using a murine dry eye model.
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Differential homing of monocytes and neutrophils in the epithelial layer of HSV-1 infected cornea regulates viral dissemination and wound healing Ocul. Surf. (IF 5.9) Pub Date : 2025-01-08 Mizumi Setia, Pratima Krishna Suvas, Mashidur Rana, Anish Chakraborty, Susmit Suvas
To ascertain the homing of monocytes and neutrophils in the epithelium versus stroma of HSV-1 infected corneas at different stages of infection and functional significance of their anatomical location in virus-infected corneas.
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Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation Ocul. Surf. (IF 5.9) Pub Date : 2025-01-06 Seiya Fukuoka, Naoki Adachi, Erika Ouchi, Hideshi Ikemoto, Takayuki Okumo, Fumihiro Ishikawa, Hidetoshi Onda, Masataka Sunagawa
Mechanical stress on the ocular surface, such as from eye-rubbing, has been reported to lead to inflammation and various ocular conditions. We hypothesized that the mechanosensitive Piezo1 channel in the conjunctival epithelium contributes to the inflammatory response at the ocular surface after receiving mechanical stimuli.
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Systems biology of dry eye: Unraveling molecular mechanisms through multi-omics integration Ocul. Surf. (IF 5.9) Pub Date : 2024-12-31 Zhirui Zhang, Changxing Liu, Lingying Zhao, Jing Yao
Dry eye disease (DED) is a multifactorial condition with complex and incompletely understood molecular mechanisms. Advances in multi-omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and microbiomics, have provided new insights into the pathophysiology of DED. Genomic analyses have identified key genetic variants linked to immune regulation and lacrimal gland function
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Clinical practice patterns in the management of dry eye disease: A TFOS international survey 2023-24 Ocul. Surf. (IF 5.9) Pub Date : 2024-12-30 James S. Wolffsohn, David A. Semp, Debarun Dutta, Lyndon Jones, Jennifer P. Craig, the TFOS ambassadors
To understand current clinical management of dry eye disease (DED), based on its perceived severity and subtype, by practitioners across the world.
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Epidemiological insights into Childhood vernal keratoconjunctivitis in India: Unravelling clinical presentation and environmental influences – The EPIC VKC study – Fourth report of the ICMR EYE SEE study group Ocul. Surf. (IF 5.9) Pub Date : 2024-12-30 Yogita Gupta, Radhika Tandon, Praveen Vashisht, Vivek Gupta, Jyoti Bhuyan, Sachchidanand Singh, G.V.S. Murthy
To study the epidemiology and clinical presentation of allergic eye diseases (AEDs) and Vernal Keratoconjunctivitis (VKC).
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AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial Ocul. Surf. (IF 5.9) Pub Date : 2024-12-28 Fiona Stapleton, Mark Hinds, Jacqueline Tan, Lyndon Jones, Robin Chalmers, Charles Bosworth, Yair Alster
Contact lens discomfort (CLD) is a common problem for CL wearers, and patients with CLD often have changes in meibomian gland function and structure. In a Phase 2 trial AZR-MD-001 0.5% (AZR) ophthalmic ointment improved meibomian gland dysfunction (MGD) in non-lens wearers. The current study evaluated the efficacy and safety of AZR in participants with CLD and concomitant MGD.
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Severe corneal manifestations of graft-versus-host disease: Experience of a tertiary referral center Ocul. Surf. (IF 5.9) Pub Date : 2024-12-20 A. Bourdin, V. Gournay, S. Doan, P.H. Prata, E. Kaphan, D. Michonneau, G. Socié, R. Peffault de Latour, E.E. Gabison
Graft-versus-host disease (GVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). GVHD may affect several organs, including ocular manifestations, ranging from dry eye syndrome to sight-threatening corneal ulceration or perforation. Limited information is available about characteristics and treatments of ocular GVHD and its relation to general prognosis
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The role of lysophosphatidic acid and its receptors in corneal nerve regeneration Ocul. Surf. (IF 5.9) Pub Date : 2024-12-20 Maryam Kheyrollah, Nicola Brandt, Anja U. Bräuer, Stefan Schrader, Sonja Mertsch
The integrity of corneal nerves is critical for ocular surface health, and damages can lead to Neurotrophic Keratopathy (NK). Despite the regenerative abilities of the peripheral nerve system (PNS), corneal nerve regeneration is often incomplete, and the underlying mechanisms are poorly understood. This study aims to identify potential factors that can enhance corneal nerve regeneration for NK treatment
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Pipeline: Pricing for drugs treating dry eye disease Ocul. Surf. (IF 5.9) Pub Date : 2024-12-17 S. Osman Hussain, Gary D. Novack
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Neuropsin, TRPV4 and intracellular calcium mediate intrinsic photosensitivity in corneal epithelial cells Ocul. Surf. (IF 5.9) Pub Date : 2024-12-15 Luka Lapajne, Monika Lakk, Christopher N. Rudzitis, Shruti Vemaraju, Richard A. Lang, Marko Hawlina, David Križaj
To investigate intrinsic phototransduction in the corneal epithelium and its role in intracellular and inflammatory signaling.
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Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence Ocul. Surf. (IF 5.9) Pub Date : 2024-12-12 Sana Iqbal, Abhishek Ramini, Simon Kaja
Exposure to particulate matter (PM) and air pollution has been implicated in the etiology of ocular surface diseases (OSD). The purpose of this systematic review is to evaluate and synthesize peer-reviewed literature on the impact of PM exposure on the ocular surface, integrating results from preclinical in vitro and in vivo studies with clinical findings to provide a comprehensive understanding of
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Deciphering S1P downregulation and sphingolipid homeostasis disruption in fungal keratitis via multi-omics and MALDI-MSI analysis Ocul. Surf. (IF 5.9) Pub Date : 2024-12-09 Zhenyuan Fu, Jing Zhong, Lixia Lin, Jiahui Yang, Yichen Xiao, Lei Li, Jing Zhang, Jin Yuan
The absence of effective treatment strategies in Fungal Keratitis (FK) emphasizes the critical need to understand the pathogenic mechanisms to enhance therapeutic outcomes. Sphingolipids have been proved to play a pivotal role in the pathogenesis of fungal infections, but the specific alteration in sphingolipids and regulatory pathways remain elusive. Our aim is to gain insight into the pathophysiological
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Prevalence of dry eye disease among Hong Kong aquatic athletes before and after COVID-19: An exploratory study Ocul. Surf. (IF 5.9) Pub Date : 2024-12-02 Ming Hong Wong, Anqi Lyu, Yu Him Lam, Zoe Yau, Allen MY. Cheong
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A systematic review assessing the quality of patient reported outcome measures in ocular surface disease Ocul. Surf. (IF 5.9) Pub Date : 2024-12-02 Pawan Baral, Sheela Kumaran, Fiona Stapleton, Konrad Pesudovs
To identify and assess the quality of currently available validated patient reported outcome measures (PROMs) used to measure the quality of life (QoL) impacts of ocular surface diseases (OSDs).
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The effect of botulinum neurotoxin A injections on meibomian glands and dry eye Ocul. Surf. (IF 5.9) Pub Date : 2024-11-30 Ali Sawaed, Shakad Noah Friedrich, Abed Farhan, Aseel Nassar, Mira Hamed, Morris Hartstein, Shirin Hamed Azzam
To assess the influence of Botulinum neurotoxin A (BoNT-A) injection on meibomian gland function and dry eye in patients diagnosed with Blepharospasm (BPS) and Hemifacial spam (HFS).
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Matrix glycosaminoglycans and proteoglycans in human cornea organoids and similarities with fetal corneal stages Ocul. Surf. (IF 5.9) Pub Date : 2024-11-28 Sean Ashworth, Manas Dhanuka, Alireza Khodadadi-Jamayran, Madhuri Amulya Koduri, George Maiti, Shukti Chakravarti
We developed human cornea organoids (HCOs) from induced pluripotent stem cells (iPSCs) where single-cell RNA-sequence (scRNA-seq) analysis suggested similarity with developing rather than mature human corneas. We performed immunohistology to determine the presence of corneal glycosaminoglycans as an assessment of maturity.
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Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial Ocul. Surf. (IF 5.9) Pub Date : 2024-11-28 Laura E. Downie, Jennifer P. Craig, Fiona Stapleton, Jacqueline Tan, Lyndon W. Jones, Alison Ng, Mark Hinds, Charles Bosworth, Yair Alster
To determine the efficacy and safety of AZR-MD-001 (0.5 % and 1.0 %) ophthalmic ointment, relative to vehicle, over 3–6 months of treatment, in participants with meibomian gland dysfunction (MGD).
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Ocular surface squamous neoplasia: Update on genetics, epigenetics and opportunities for targeted therapy Ocul. Surf. (IF 5.9) Pub Date : 2024-11-26 Nefeli Eleni Kounatidou, Evangelos Vitkos, Sotiria Palioura
The purpose of this review is to explore the molecular foundations of ocular surface squamous neoplasia (OSSN), focusing on the genetic and epigenetic aspects. While current management strategies include surgical excision and medical therapies, the understanding of OSSN's molecular basis remains limited, hindering the development of targeted treatments.