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Pipeline: Ocular biostatistics: Which is better: One or two? Ocul. Surf. (IF 6.4) Pub Date : 2023-11-22 Gary D. Novack
Abstract not available
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A new treatment changes the game: An innovative management of a child suffering from severe ligneous conjunctivitis with type 1 plasminogen deficiency Ocul. Surf. (IF 6.4) Pub Date : 2023-11-20 M. Desira, E. Gabison, P.V. Jacomet, D. Denis, F. Dalmas, T. David, A. Aziz
Abstract not available
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Corneal neuroepithelial compartmentalized microfluidic chip model for evaluation of toxicity-induced dry eye Ocul. Surf. (IF 6.4) Pub Date : 2023-11-19 Noémie Bonneau, Anaïs Potey, Michael-Adrien Vitoux, Romain Magny, Camille Guerin, Christophe Baudouin, Jean-Michel Peyrin, Françoise Brignole-Baudouin, Annabelle Réaux-Le Goazigo
Part of the lacrimal functional unit, the cornea protects the ocular surface from numerous environmental aggressions and xenobiotics. Toxicological evaluation of compounds remains a challenge due to complex interactions between corneal nerve endings and epithelial cells. To this day, models do not integrate the physiological specificity of corneal nerve endings and are insufficient for the detection
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Recent advances in age-related meibomian gland dysfunction (ARMGD) Ocul. Surf. (IF 6.4) Pub Date : 2023-11-17 Isabel Moreno, Sudhir Verma, Tarsis Ferreira Gesteira, Vivien J. Coulson- Thomas
Meibomian glands (MGs), located within the tarsal plate of the eyelid, secrete meibum which is the lipid-rich secretion necessary for stabilizing the tear film and preventing tear evaporation. Changes in the quality and quantity of meibum produced causes MG dysfunction (MGD), the leading cause of evaporative dry eye disease (EDED). MGD is an underdiagnosed disease and it is estimated that, in the US
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Impaired healing in an incision wound in corneal stroma in a lumican-null mouse Ocul. Surf. (IF 6.4) Pub Date : 2023-11-14 Eimi Suzuki, Takayoshi Sumioka, Shizuya Saika, Masayasu Miyajima, Shingo Yasuda, Hiroki Iwanishi, Yukihisa Takada, Kana Ichikawa, Jhuwala Venkatakrishnan, Chia-Yang Liu, Winston Whei-Yang Kao, Yuka Okada
Purpose We investigated healing pattern of an incisional wound in corneal stroma of lumican-null (KO) mice. Methods C57BL/6 mice (wild-type, WT) and lumican-null (knockout, KO) mice were used. A linear full-thickness incision was produced in one cornea of each mouse. After intervals of healing, the corneas were processed for the following analyses. Histology was employed to measure the distance between
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Patients with neurotrophic keratitis demonstrate alterations in ocular surface expression of transient receptor potential (TRP) channels Ocul. Surf. (IF 6.4) Pub Date : 2023-11-07 Alessandro Lambiase, Fabiana Mallone, Marta Sacchetti, Marco Segatto, Mayra Colardo, Valerio Di Martino, Alice Bruscolini
Abstract not available
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Readership awareness series – Paper 7: An overview of impact factor and other scientometrics Ocul. Surf. (IF 6.4) Pub Date : 2023-10-09 Mohammad Javed Ali, Ali Djalilian
Abstract not available
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Safety and efficacy of intense pulsed light in the treatment of severe chronic ocular graft-versus-host disease Ocul. Surf. (IF 6.4) Pub Date : 2023-10-07 He Wang, Xiaoyue Yin, Yue Li, Zhaowei Zhang, Kai Zhao, Fen Hu, Qian Liu, Qiuchen Lu, Yining Wang, Ling Zhang, Hui Jia, Jiaxin Han, Jianxin Guo, Mingxin Li
Objective To investigate the safety and efficacy of intense pulsed light (IPL) in the treatment of severe chronic ocular graft-versus-host disease (coGVHD). Methods A prospective cohort study. Seventeen patients with severe coGVHD were selected for inclusion in this study. All subjects were treated with IPL every fortnight together with conventional treatment, observation time points were pre-treatment
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Perfluorohexyloctane in dry eye disease: A systematic review of its efficacy and safety as a novel therapeutic agent Ocul. Surf. (IF 6.4) Pub Date : 2023-10-07 Antonio Ballesteros-Sánchez, Concepción De-Hita-Cantalejo, María Carmen Sánchez-González, Zane Jansone-Langine, Maria Alvarez de Sotomayor, Josip Culig, José-María Sánchez-González
Perfluorohexyloctane (F6H8), a physically and chemically inert synthetic compound, has recently emerged as a promising candidate for the treatment of DED due to its unique properties. A systematic review that only include full-length randomized controlled studies (RCTs), reporting the effects of F6H8 in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement
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Greater adherence to a mediterranean diet is associated with lower C-reactive protein (CRP) levels, but not to lower odds of having dry eye disease Ocul. Surf. (IF 6.4) Pub Date : 2023-10-01 Morten Schjerven Magno, Emily Moschowits, Mathias Kaurstad Morthen, Marie Wangen Beining, Nomdo M. Jansonius, Christopher J. Hammond, Tor P. Utheim, Jelle Vehof
Purpose To investigate the hypothesis that a Mediterranean diet is associated with a lower risk of having dry eye disease (DED) in the general population. Methods DED was assessed using the Women's Health Study (WHS) dry eye questionnaire in 58,993 participants from the Dutch Lifelines Cohort with complete available dietary data (20–94 years, 60% female). Level of adherence to a traditional Mediterranean
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New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering Ocul. Surf. (IF 6.4) Pub Date : 2023-09-28 Swati Singh, Zoltan Winter, Fabian Necker, Tobias Bäuerle, Michael Scholz, Lars Bräuer, Friedrich Paulsen
Purpose To study the tissue architecture, isthmus (connection between two lobes) of the lacrimal gland using preclinical 7T MRI in combination with histology and electron microscopy. Methods Ten lacrimal glands from Caucasian body donors (mean age 78.7 years) were studied using 7T-MRI (N = 5; scanned at 75-μm intervals), histology, and electron microscopy (N = 5) and 3D cinematic rendering (CR) techniques
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Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells Ocul. Surf. (IF 6.4) Pub Date : 2023-09-26 Menglu Yang, Vanessa Delcroix, Anton Lennikov, Nicholas Wang, Helen P. Makarenkova, Darlene A. Dartt
Purpose Primary Sjögren's syndrome (pSS) is an autoimmune disease that mainly attacks the lacrimal glands causing severe aqueous-deficient dry eye. Clinical evidence indicates the DNA sensing mechanism in the pathogenesis of pSS. The purpose of the present study is to determine the pro-inflammatory effect of self-genomic DNA (gDNA) on myoepithelial cells (MECs), which along with acinar and ductal cells
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Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing Ocul. Surf. (IF 6.4) Pub Date : 2023-09-22 Sudhir Verma, Fernando T. Ogata, Isabel Y. Moreno, Cassio Prinholato da Silva, Tainah Dorina Marforio, Matteo Calvaresi, Mehmet Sen, Vivien J. Coulson-Thomas, Tarsis Ferreira Gesteira
Purpose Lumican is a major extracellular matrix (ECM) component in the cornea that is upregulated after injury and promotes corneal wound healing. We have recently shown that peptides designed based on the 13 C-terminal amino acids of lumican (LumC13 and LumC13C-A) are able to recapitulate the effects of lumican on promoting corneal wound healing. Herein we used computational chemistry to develop peptide
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Intrastromal versus subconjunctival injection of mesenchymal stem/stromal cells for promoting corneal repair Ocul. Surf. (IF 6.4) Pub Date : 2023-09-25 Mohammad Soleimani, Reza Mirshahi, Kasra Cheraqpour, Seyed Mahbod Baharnoori, Hamed Massoumi, Collin Chow, Sumaiya Shahjahan, Bita Momenaei, Mohammad Javad Ashraf, Raghuram Koganti, Mahmood Ghassemi, Khandaker N. Anwar, Elmira Jalilian, Ali R. Djalilian
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Evaluation of ocular neuropathic pain Ocul. Surf. (IF 6.4) Pub Date : 2023-09-23 Damien Tuan-Man Le, Himal Kandel, Stephanie L. Watson
Aim To identify and assess the quality of current validated questionnaires that could be used to evaluate ocular neuropathic pain and its associated aetiologies. Methods A literature search was performed on MEDLINE, PubMed, EMBASE, PsycINFO and The Cochrane Library. Articles evaluating questionnaires for ocular neuropathic pain and its associated aetiologies were included. Data on psychometric properties
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Murine models of graft versus host disease (GVHD): Focus on ocular GVHD Ocul. Surf. (IF 6.4) Pub Date : 2023-09-22 Philipp Steven, Victor L. Perez, Ajay Sharma
Graft versus host disease (GVHD) remains a major and serious complication of allogeneic hematopoietic stem cell transplantation. Based on the time of onset, clinical phenotypes, progression kinetics, and pathophysiology, GVHD is stratified into acute, chronic, and overlapping types. The eyes are among the most commonly affected organs in GVHD. Mouse models have played an important role in understanding
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Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration Ocul. Surf. (IF 6.4) Pub Date : 2023-09-09 Filippo Bonelli, Ibrahim Demirsoy, Romina Mayra Lasagni Vitar, Philippe Fonteyne, Giulio Ferrari
Purpose To test long-term ocular toxicity and analgesic/anti-inflammatory efficacy of two novel ocular formulations of neurokinin 1 receptor (NK1R) antagonist Aprepitant. Methods for toxicity studies, two Aprepitant formulations (X and Y) were tested on C57BL/6 N mice. Gold standards were 0.4% Oxybuprocaine, 0.1% Diclofenac, or saline. For efficacy studies, C57BL/6 N mice underwent corneal alkali burn
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Conjunctival transcriptomics in ocular mucous membrane pemphigoid Ocul. Surf. (IF 6.4) Pub Date : 2023-09-09 Jesse Panthagani, Kusy Suleiman, Rachel C. Vincent, Hon Shing Ong, Graham R. Wallace, Saaeha Rauz
Purpose Ocular Mucous Membrane Pemphigoid (OcMMP) is an orphan disease characterized by chronic autoimmune-driven conjunctival inflammation leading to progressive scarring, debilitating symptoms, and blinding sequelae. This feasibility study aims to demonstrate conjunctival genetic transcriptomic analyses as a putative tool for interrogation of pathogenic signaling pathways in OcMMP. Methods Conjunctival
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Retinol palmitate in management of chronic Steven-Johnson Syndrome with ocular surface keratinization Ocul. Surf. (IF 6.4) Pub Date : 2023-09-07 Ananya Parampalli Ravindra, Rajesh Sinha, Aafreen Bari, T. Velpandian, Seema Sen, Tushar Agarwal, Namrata Sharma, Jeewan Singh Titiyal
Purpose To study the outcomes of topical Retinol Palmitate ophthalmic solution in chronic Stevens-Johnson Syndrome with ocular surface keratinisation. Methods It was a comparative interventional study conducted at Rajendra Prasad Centre for Ophthalmic Sciences, Delhi, India from 2020 to 2022 evaluating outcomes of addition of topical Retinol Palmitate to conventional treatment objectively as well as
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A review of the epithelial and stromal effects of corneal collagen crosslinking Ocul. Surf. (IF 6.4) Pub Date : 2023-09-06 Samantha Bradford, Shangbang Luo, Donald Brown, Tibor Juhasz, James Jester
Induced corneal collagen crosslinking and mechanical stiffening via ultraviolet-A photoactivation of riboflavin (UVA CXL) is now a common treatment for corneal ectasia and Keratoconus. Some effects of the procedure such as induced mechanical stiffening, corneal flattening, and cellular toxicity are well-known, but others remain more controversial. Authors report a variety of contradictory effects,
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Glycosaminoglycans: Roles in wound healing, formation of corneal constructs and synthetic corneas Ocul. Surf. (IF 6.4) Pub Date : 2023-08-30 Kristen L. Segars, Vickery Trinkaus-Randall
Maintaining the clarity of the cornea is essential for vision, and is achieved through an exquisite array of collagen fibrils and proteoglycans in the corneal stroma. Alterations in the identity and modifications of the glycosaminoglycans (GAGs) are seen both throughout the normal wound healing process and in pathological conditions resulting in corneal opacity. Understanding these changes has been
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Neurotrophic keratopathy: An updated understanding Ocul. Surf. (IF 6.4) Pub Date : 2023-09-04
Purpose To propose an updated definition and staging system for neurotrophic keratopathy (NK) and provide consensus on diagnosis and treatment. Methods A study group was convened to review the data pertinent to NK using a modified nominal group process. They proposed an updated definition for NK and a new 6-step staging system (Neurotrophic Keratopathy Study Group [NKSG] Classification) that can be
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TFOS Lifestyle Report Executive Summary: A Lifestyle Epidemic - Ocular Surface Disease Ocul. Surf. (IF 6.4) Pub Date : 2023-09-01 Jennifer P. Craig, Monica Alves, James S. Wolffsohn, Laura E. Downie, Nathan Efron, Anat Galor, José Alvaro P. Gomes, Lyndon Jones, Maria Markoulli, Fiona Stapleton, Christopher E. Starr, Amy Gallant Sullivan, Mark D.P. Willcox, David A. Sullivan
The Tear Film & Ocular Surface Society (TFOS) Workshop entitled ‘A Lifestyle Epidemic: Ocular Surface Disease’ was a global initiative undertaken to establish the direct and indirect impacts of everyday lifestyle choices and challenges on ocular surface health. This article presents an executive summary of the evidence-based conclusions and recommendations of the 10-part TFOS Lifestyle Workshop report
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Diagnostic capacity for fungal keratitis in Africa – Survey in 50 African countries Ocul. Surf. (IF 6.4) Pub Date : 2023-09-01 Jean Claude Makangara Cigolo, Rita O. Oladele, Stephen B. Kennedy, Michelle Bignoumba, Hassane Mahamat Hassane, Victor Bucumi, Guyguy Kamwiziku, Stephen Kojo Eduful, Alice Afonso Manjate, Sahra Isse Mohamed, Furahini Mbise, Mutinta E. Shisholeka, Richard O.S. Penney, Emma Orefuwa, David W. Denning
Abstract not available
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Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction Ocul. Surf. (IF 6.4) Pub Date : 2023-08-22 Guoliang Wang, Lina Xu, Ruize Shi, Yingyue Ye, Baihui Zeng, Xiuqin Yang, Zeyu Liu, Zhen Liu, Shurong Wang, Yuhua Xue, Cheng Li
Purpose Meibomian glands (MGs) are crucial for maintaining tear film stability and ocular surface health. Here, we aim to establish a novel organotypic culture model of MGs and explore the risk factors of MG dysfunction (MGD). Methods We developed a novel organotypic culture model for MGs at the air-liquid interface. The viability and cell proliferation of MGs were assessed using CCK-8, immunofluorescence
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TNF is a critical cytokine in age-related dry eye disease Ocul. Surf. (IF 6.4) Pub Date : 2023-08-25 Yashaswini Kelagere, Kaitlin K. Scholand, Erica N. DeJong, Andrea I. Boyd, Zhiyuan Yu, Roger A. Astley, Michelle C. Callegan, Dawn ME. Bowdish, Helen P. Makarenkova, Cintia S. de Paiva
Aging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs. Using genetic and pharmacological approaches, we investigated
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A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells Ocul. Surf. (IF 6.4) Pub Date : 2023-08-25 Lina Xu, Guoliang Wang, Ruize Shi, Baihui Zeng, Yan Zhang, Zhen Liu, Shurong Wang, Nuo Dong, Cheng Li
Purpose The conjunctival epithelial cells cultured with bovine serum or feeder cells were not suitable for clinical application. Therefore, we developed a novel serum-free and feeder cell-free culture system containing only a cocktail of three chemicals (3C) to expand the conjunctival epithelial cells. Methods The cell proliferative ability was evaluated by counting, crystal violet staining and Ki67
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Dry eye disease sustainability Ocul. Surf. (IF 6.4) Pub Date : 2023-08-22 Francesc March de Ribot, Jose M. Benitez Del Castillo, Gerd Geerling, Elisabeth M. Messmer, Christophe Baudouin, Monica Alves
Abstract not available
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Tear film changes in symptomatic versus asymptomatic video display terminal users following computer challenge test Ocul. Surf. (IF 6.4) Pub Date : 2023-08-16 Saumya Srivastav, Sayan Basu, Swati Singh
Purpose To assess the real-time changes in the tear film and ocular surface of symptomatic video display terminal (VDT) versus asymptomatic users. Methods A total of 35 symptomatic (29 ± 5.6 years; Group 1, mild dry eye disease) and 35 asymptomatic (24.1 ± 4.6 years; Group 2) VDT users with a mean OSDI of 28 ± 11 and 0.86 ± 2.1, respectively, had tear film examination (Oculus Keratograph 5 M and Tearlab
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Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery Ocul. Surf. (IF 6.4) Pub Date : 2023-08-03 Satinder Kaur, Peri Sohnen, Sudha Swamynathan, Yiqin Du, Edgar M. Espana, Shivalingappa K. Swamynathan
The structural and functional integrity of the ocular surface, a continuous epithelial structure comprised of the cornea, the conjunctiva, and the ductal surface of the lacrimal as well as meibomian glands, is crucial for proper vision. The ocular surface barrier function (OSBF), sum of the different types of protective mechanisms that exist at the ocular surface, is essential to protect the rest of
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Clinical trials submissions to The Ocular Surface Ocul. Surf. (IF 6.4) Pub Date : 2023-08-06 Gary D. Novack, Cintia S. de Paiva
Abstract not available
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The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea Ocul. Surf. (IF 6.4) Pub Date : 2023-08-02 Weifeng Li, Katherine Gurdziel, Ahalya Pitchaikannu, Naman Gupta, Linda D. Hazlett, Shunbin Xu
Purpose The conserved miR-183/96/182 cluster (miR-183C) regulates both corneal sensory innervation and corneal resident immune cells (CRICs). This study is to uncover its role in CRICs and in shaping the corneal cellular landscape at a single-cell (sc) level. Methods Corneas of naïve, young adult [2 and 6 months old (mo)], female miR-183C knockout (KO) mice and wild-type (WT) littermates were harvested
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Neurotrophic keratopathy associated with cancer immunotherapy targeting programmed death 1 Ocul. Surf. (IF 6.4) Pub Date : 2023-08-01 Ziyan Chen, Yinglin Liao, Hubert Yuenhei Lao, Lingyi Liang
Abstract not available
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Herpes simplex virus-1 conjunctival dendrite in an immunosuppressed patient Ocul. Surf. (IF 6.4) Pub Date : 2023-07-26 Jessica Y. Walia, Andrew J.W. Huang, Todd P. Margolis
Abstract not available
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Gene expression signatures in conjunctival fornix aspirates of patients with dry eye disease associated with Meibomian gland dysfunction. A proof-of-concept study Ocul. Surf. (IF 6.4) Pub Date : 2023-07-29 Carlos Vergés, Ana Giménez-Capitán, Verónica Ribas, José Salgado-Borges, Francesc March de Ribot, Clara Mayo-de-las-Casas, Noelia Armiger-Borras, Carlos Pedraz, Miguel Ángel Molina-Vila
Background Meibomian gland dysfunction (MGD) is one of the most common conditions in ophthalmic practice and the most frequent cause of evaporative dry eye disease (DED). However, the immune mechanisms leading to this pathology are not fully understood and the diagnostic tests available are limited. Here, we used the nCounter technology to analyze immune gene expression in DED-MGD that can be used
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Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption Ocul. Surf. (IF 6.4) Pub Date : 2023-07-27 Anmar Abu-Romman, Kaitlin K. Scholand, Sonali Pal-Ghosh, Zhiyuan Yu, Yashaswini Kelagere, Ghasem Yazdanpanah, Winston W-Y Kao, Vivien J. Coulson-Thomas, Mary Ann Stepp, Cintia S. de Paiva
Purpose IL-2 promotes activation, clonal expansion, and deletion of T cells. IL-2 signals through its heterotrimeric receptor (IL-2R) consisting of the CD25, CD122 and CD132 chains. CD25 knockout (KO) mice develop Sjögren Syndrome-like disease. This study investigates whether corneal CD25/IL-2 signaling is critical for ocular health. Methods Eyes from C57BL/6 mice were collected and prepared for immunostaining
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Readership awareness series - Paper 6: How to write a good peer review report? Ocul. Surf. (IF 6.4) Pub Date : 2023-07-22 Mohammad Javed Ali, Ali Djalilian
Abstract not available
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Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial Ocul. Surf. (IF 6.4) Pub Date : 2023-07-20
Purpose Meibomian gland dysfunction (MGD) is a chronic progressive disease with downstream effects on ocular signs and symptoms. AZR-MD-001 is a selenium sulfide ophthalmic ointment that was investigated as a potential treatment option for patients with MGD. Methods A Phase 2, multi-center, double-masked, parallel group study was conducted across 29 sites, with 245 patients randomized 1:1:1 to AZR-MD-001
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Identifying patient-valued outcomes for use in early phase trials of ocular surface disease interventions Ocul. Surf. (IF 6.4) Pub Date : 2023-07-17
Background Patient-reported outcomes (PROs) can be used to evaluate the impact of dry eye symptoms (DES) on daily life. Early-phase clinical trials provide an opportunity to evaluate PRO strategies. Existing measures identified through systematic review omitted important concepts that mattered to patients. The aim of our work was to develop a conceptual map of DES and assess the relative importance
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Wnt/β-catenin signaling controls mouse eyelid growth by mediating epithelial-mesenchymal interactions Ocul. Surf. (IF 6.4) Pub Date : 2023-07-13
Purpose To investigate the role of Wnt/β-catenin signaling in mouse eyelid development. Methods Wnt/β-catenin signaling was disrupted by deleting supraorbital mesenchymal β-catenin or epithelial Wls. p63 was removed to determine whether the expression of Wnts is affected. The eyelid morphology was examined at different stages. Proliferation, apoptosis, and expression of Wnt ligands and their target
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Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells Ocul. Surf. (IF 6.4) Pub Date : 2023-07-03 Praveen Kumar Jadi, Alpana Dave, Rahaf Issa, Khatija Tabbasum, Katarzyna Okurowska, Apurwa Samarth, Lucy Urwin, Luke R. Green, Lynda J. Partridge, Sheila MacNeil, Prashant Garg, Peter N. Monk, Sanhita Roy
Pseudomonas aeruginosa is a leading cause of corneal infection both within India and globally, often causing a loss of vision. Increasing antimicrobial resistance among the bacteria is making its treatment more difficult. Preventing initial bacterial adherence to the host membrane has been explored here to reduce infection of the cornea. Synthetic peptides derived from human tetraspanin CD9 have been
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Meibomian gland stem/progenitor cells: The hunt for gland renewal Ocul. Surf. (IF 6.4) Pub Date : 2023-07-06 Xiaowei Yang, Lixing W. Reneker, Xingwu Zhong, Andrew J.W. Huang, James V. Jester
Meibomian glands (MGs) secrete lipid (meibum) onto the ocular surface to form the outermost layer of the tear film. Proper meibum secretion is essential for stabilizing the tear film, reducing aqueous tear evaporation, and maintaining the homeostasis of the ocular surface. Atrophy of MG as occurs with aging, leads to reduction of meibum secretion, loss of ocular surface homeostasis and evaporative
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Effects of elevated serum estrogen on dry eye in women undergoing in vitro fertilisation Ocul. Surf. (IF 6.4) Pub Date : 2023-07-06 Archana Boga, Fiona Stapleton, Michael Chapman, Blanka Golebiowski
Purpose Sex hormones impact inflammatory and immune-mediated diseases. During IVF (in vitro fertilisation) treatment, circulating estrogen levels increase dramatically (10–50x) alongside changes in other hormones. This study examined changes in dry eye with IVF and its relationship with sex hormones. Methods A two visit study was conducted on first day of menstruation when estrogen levels are lowest
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Readership awareness series - Paper 5: The peer review process Ocul. Surf. (IF 6.4) Pub Date : 2023-07-05 Mohammad Javed Ali, Ali Djalilian
Abstract not available
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TGF beta receptor II (Tbr2) deficiency in keratocytes results in corneal ectasia Ocul. Surf. (IF 6.4) Pub Date : 2023-06-30 Yen-Chiao Wang, Olivia Betty Zolnik, Shingo Yasudo, Lung-Kun Yeh, Yong Yuan, Winston Kao, Shizuya Saika, Chia-Yang Liu
Purpose We hypothesized that TGF beta receptor 2 (Tbr2) deletion (Δ) in the corneal stroma (Tbr2Δ/Δcst) can result in corneal thinning and generate a potential model for cornea ectasia. Methods Corneal thickness of Tbr2Δ/Δcst and Tbr2Δ/+cst was examined with Optical Coherence Tomography (OCT) at post-natal (P) days 42 and 70, respectively. Histological H&E staining, transmission electron micrograph
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1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface Ocul. Surf. (IF 6.4) Pub Date : 2023-06-28 Chang Ho Yoon, Hyun-Jae Jang, Jin Suk Ryu, Jung Hwa Ko, Kyung-Seop Ahn, Sei-Ryang Oh, Jang-Hee Oh, Jin Ho Chung, Joo Youn Oh
Purpose Pseudognaphalium affine (P. affine), a medicinal plant, has long been used to treat various diseases due to its astringent and vulnerary effects. These therapeutic benefits are largely attributed to high contents of phytochemicals, such as flavonoids and polyphenols, that have anti-inflammatory and tissue-protective activities. Herein, we investigated the potential of dicaffeoylquinic acids
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Automated identification and quantification of activated dendritic cells in central cornea using artificial intelligence Ocul. Surf. (IF 6.4) Pub Date : 2023-06-27 Harry Levine, Arianna Tovar, Adam K. Cohen, Kimberly Cabrera, Elyana Locatelli, Anat Galor, William Feuer, Robert O'Brien, Brian E. Goldhagen
Purpose To validate an algorithm quantifying activated dendritic cells (aDCs) using in-vivo confocal microscopy (IVCM) images. Methods IVCM images obtained at the Miami Veterans Affairs Hospital were retrospectively analyzed. ADCs were quantified both with an automated algorithm and manually. Intra-class-correlation (ICC) and a Bland-Altman plot were used to compare automated and manual counts. As
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The gene therapy for corneal pathology with novel nonsense cystinosis mouse lines created by CRISPR Gene Editing Ocul. Surf. (IF 6.4) Pub Date : 2023-06-23 Fei Dong, Hassane Amlal, Jhuwala Venkatakrishnan, Jianhua Zhang, Matthew Fry, Yong Yuan, Yu Chia Cheng, Yueh-Chiang Hu, Winston W-Y Kao
Purpose Cystinosis is an autosomal recessive lysosomal storage disease (LSDs) caused by mutations in the gene encoding cystinosin (CTNS) that leads to cystine crystal accumulation in the lysosome that compromises cellular functions resulting in tissue damage and organ failure, especially in kidneys and eyes. However, the underlying molecular mechanism of its pathogenesis remains elusive. Two novel
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Small leucine rich proteoglycans: Biology, function and their therapeutic potential in the ocular surface Ocul. Surf. (IF 6.4) Pub Date : 2023-06-22 Tarsis Ferreira Gesteira, Sudhir Verma, Vivien J. Coulson- Thomas
Small leucine rich proteoglycans (SLRPs) are the largest family of proteoglycans, with 18 members that are subdivided into five classes. SLRPs are small in size and can be present in tissues as glycosylated and non-glycosylated proteins, and the most studied SLRPs include decorin, biglycan, lumican, keratocan and fibromodulin. SLRPs specifically bind to collagen fibrils, regulating collagen fibrillogenesis
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Keratoneuropathy Ocul. Surf. (IF 6.4) Pub Date : 2023-06-16 Seyed-Farzad Mohammadi, Hossein Farrokhpour, Ghazaleh Soltani, Golshan Latifi
Abstract not available
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Anterior blepharitis is associated with elevated plectin levels consistent with a pronounced intracellular response Ocul. Surf. (IF 6.4) Pub Date : 2023-06-20 Danson Vasanthan Muttuvelu, Lasse Jørgensen Cehofski, Misk Ghassan Farik Muhammad, Xiangjun Chen, Tor Paaske Utheim, Asif Manzoor Khan, Ahmed Basim Abduljabar, Kasper Kristensen, Marie Louise Roed Rasmussen, Henrik Vorum, Steffen Heegaard, Bent Honoré
Purpose Anterior blepharitis is a frequent ocular condition which may result in severe ocular surface disease. In this study, advanced proteome analysis was performed to elucidate biological mechanisms underlying anterior blepharitis. Methods All patients underwent full ophthalmological examination including Ocular Surface Disease Index score (OSDI). Measurement of non-invasive break-up time (NBUT)
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Reply to Letter to the Editor re: TFOS lifestyle: Impact of the digital environment on the ocular surface Ocul. Surf. (IF 6.4) Pub Date : 2023-06-17 James S. Wolffsohn
Abstract not available
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Conjunctival vessel density analysis as a marker of inflammation in dry eye disease Ocul. Surf. (IF 6.4) Pub Date : 2023-06-14 Emanuela Aragona, Alessandro Arrigo, Giulio Modorati, Luigi Berchicci, Francesco Bandello, Elisabetta Miserocchi
Abstract not available
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The versatile roles of lumican in eye diseases: A review Ocul. Surf. (IF 6.4) Pub Date : 2023-06-14 Mei-Chi Tsui, Hsin-Yu Liu, Hsiao-Sang Chu, Wei-Li Chen, Fung-Rong Hu, Winston W.-Y. Kao, I-Jong Wang
Lumican is a keratan sulfate proteoglycan that belongs to the small leucine-rich proteoglycan family. Research has lifted the veil on the versatile roles of lumican in the pathogenesis of eye diseases. Lumican has pivotal roles in the maintenance of physiological tissue homogenesis and is often upregulated in pathological conditions, e.g., fibrosis, scar tissue formation in injured tissues, persistent
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Transitory alkali exposure on meibomian gland orifices induces meibomian gland dysfunction Ocul. Surf. (IF 6.4) Pub Date : 2023-06-14 Jinghua Bu, Yang Wu, Kechun Li, Minjie Zhang, Rongrong Zhang, Le Sun, Yuli Guo, Hui He, Shiying Li, Zuguo Liu, Wei Li
Purpose To determine pathological changes of meibomian glands (MGs) after transient exposure of the rat eyelid margin to alkali solution. Methods Filter paper infiltrated with 1 N sodium hydroxide solution was applied to the eyelid margin of Sprague-Dawley rats for 30 s under general anesthesia, without touching the conjunctiva, after which the ocular surface and eyelid margin were examined by slit-lamp
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Epithelial-mesenchymal transition in the lacrimal gland morphogenesis, damage and repair Ocul. Surf. (IF 6.4) Pub Date : 2023-06-14 Swati Singh, Simone Brabletz, Philipp Arnold, Martin Schicht, Friedrich Paulsen
Epithelial-mesenchymal transition (EMT) constitutes an important pathway in organ fibrosis seen in the lungs, liver, eye, and salivary glands. This review summarizes the EMT observed within the lacrimal gland during its development, tissue damage and repair along with possible translational implications. Existing animal and human studies have reported the increased expression of EMT regulators i.e
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Letter to the editor regarding “TFOS Lifestyle: Impact of the digital environment on the ocular surface” Ocul. Surf. (IF 6.4) Pub Date : 2023-06-13 Mohammed Iqbal, Ahmed Elmassry, Mervat Elgharieb, Hosam Elzembely, Omar Said
Abstract not available
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Impact of glaucoma medications on the ocular surface and how ocular surface disease can influence glaucoma treatment Ocul. Surf. (IF 6.4) Pub Date : 2023-06-09 Miriam Kolko, Gus Gazzard, Christophe Baudouin, Sofie Beier, Françoise Brignole-Baudouin, Barbara Cvenkel, Fredrik Fineide, Anne Hedengran, Anton Hommer, Erik Jespersen, Elisabeth M. Messmer, Rachna Murthy, Amy Gallant Sullivan, Andrew J. Tatham, Tor Paaske Utheim, Marijke Vittrup, David A. Sullivan
Abstract not available
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Ocular involvement in Clarkson Disease Ocul. Surf. (IF 6.4) Pub Date : 2023-06-09 Sara Spelta, Antonio Di Zazzo, Alessandra Micera, Matteo Cervellini, Marco Coassin, Stefano Bonini
Abstract not available
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New trends towards glaucoma treatment: Topical osmoprotective microemulsions loaded with latanoprost Ocul. Surf. (IF 6.4) Pub Date : 2023-06-08 J.J. López-Cano, M.A. González-Cela-Casamayor, V. Andrés-Guerrero, M. Vicario -de-la-Torre, J.M. Benítez-del-Castillo, R. Herrero-Vanrell, I.T. Molina-Martínez