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6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens J. Med. Chem. (IF 6.054) Pub Date : 2020-03-31 Diana Rodríguez; María Maneiro; Juan C. Vázquez-Ucha; Alejandro Beceiro; Concepción González-Bello
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Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model J. Med. Chem. (IF 6.054) Pub Date : 2020-03-31 Jihui Zhao; Rongrong Cui; Lihao Wang; Yingjia Chen; Zunyun Fu; Xiaoyu Ding; Chen Cui; Tianbiao Yang; Xutong Li; Yuan Xu; Kaixian Chen; Xiaomin Luo; Hualiang Jiang; Mingyue Zheng
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pH-Dependent Grafting of Cancer Cells with Antigenic Epitopes Promotes Selective Antibody-Mediated Cytotoxicity J. Med. Chem. (IF 6.054) Pub Date : 2020-03-30 Janessa Wehr; Eden L. Sikorski; Elizabeth Bloch; Mary S. Feigman; Noel J. Ferraro; Trevor R. Baybutt; Adam E. Snook; Marcos M. Pires; Damien Thévenin
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LMP2 Inhibitors as a Potential Treatment for Alzheimer’s Disease J. Med. Chem. (IF 6.054) Pub Date : 2020-03-30 Deepak Bhattarai; Min Jae Lee; Ahruem Baek; In Jun Yeo; Zachary Miller; Yu Mi Baek; Sukyeong Lee; Dong-Eun Kim; Jin Tae Hong; Kyung Bo Kim
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Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity J. Med. Chem. (IF 6.054) Pub Date : 2020-03-30 Jose M. Arencibia; Nicoletta Brindani; Sebastian Franco-Ulloa; Michela Nigro; Jissy Akkarapattiakal Kuriappan; Giuliana Ottonello; Sine Mandrup Bertozzi; Maria Summa; Stefania Girotto; Rosalia Bertorelli; Andrea Armirotti; Marco De Vivo
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Rational Substitution of ε-Lysine for α-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin J. Med. Chem. (IF 6.054) Pub Date : 2020-03-30 Venkatesh Mayandi; Qingxiao Xi; Eunice Tze Leng Goh; Siew Kwan Koh; Thomas Yong Jie Toh; Veluchamy Amutha Barathi; Mobashar Hussain Urf Turabe Fazil; Madhavi Latha Somaraju Chalasani; Jayasudha Varadarajan; Darren Shu Jeng Ting; Roger W. Beuerman; Lai Wah Chan; Rupesh Agrawal; Timothy Mark Sebastian Barkham; Lei Zhou; Navin Kumar Verma; Rajamani Lakshminarayanan
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(S)-3-(Carboxyformamido)-2-(3-(carboxymethyl)ureido)propanoic Acid as a Novel PSMA Targeting Scaffold for Prostate Cancer Imaging J. Med. Chem. (IF 6.054) Pub Date : 2020-03-30 Xiaojiang Duan; Futao Liu; Hongmok Kwon; Youngjoo Byun; Il Minn; Xuekang Cai; Jingming Zhang; Martin G. Pomper; Zhi Yang; Zhen Xi; Xing Yang
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Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus J. Med. Chem. (IF 6.054) Pub Date : 2020-03-27 Arun Kapoor; Ayan K. Ghosh; Michael Forman; Xin Hu; Wenjuan Ye; Noel Southall; Juan Marugan; Robert F. Keyes; Brian C. Smith; David J. Meyers; Marc Ferrer; Ravit Arav-Boger
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N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition J. Med. Chem. (IF 6.054) Pub Date : 2020-03-26 Daniele Piomelli; Laura Scalvini; Yannick Fotio; Alessio Lodola; Gilberto Spadoni; Giorgio Tarzia; Marco Mor
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Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds J. Med. Chem. (IF 6.054) Pub Date : 2020-03-26 Irene G. Salado; Abhimanyu K. Singh; Carlos Moreno-Cinos; Guna Sakaine; Marco Siderius; Pieter Van der Veken; An Matheeussen; Tiffany van der Meer; Payman Sadek; Sheraz Gul; Louis Maes; Geert-Jan Sterk; Rob Leurs; David Brown; Koen Augustyns
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How We Think about Targeting RNA with Small Molecules J. Med. Chem. (IF 6.054) Pub Date : 2020-03-26 Matthew G. Costales; Jessica L. Childs-Disney; Hafeez S. Haniff; Matthew D. Disney
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Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors J. Med. Chem. (IF 6.054) Pub Date : 2020-03-26 Simona Di Martino; Piero Tardia; Vincenzo Cilibrasi; Samantha Caputo; Marco Mazzonna; Debora Russo; Ilaria Penna; Natalia Realini; Natasha Margaroli; Marco Migliore; Daniela Pizzirani; Giuliana Ottonello; Sine Mandrup Bertozzi; Andrea Armirotti; Duc Nguyen; Ying Sun; Ernesto R. Bongarzone; Peter Lansbury; Min Liu; Renato Skerlj; Rita Scarpelli
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Drug Distribution in Living Cells via Label-Free Molecular Fingerprint J. Med. Chem. (IF 6.054) Pub Date : 2020-03-25 Samir F. El-Mashtoly
A new application of stimulated Raman scattering (SRS) uses the benefit of a label-free molecular fingerprint to image the uptake and distribution of an alkyne-based drug in living cells. This method delivers information on cellular molecular composition and drug–cell interaction, showing the potential of SRS in drug development.
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Investigation of Inactive-State κ Opioid Receptor Homodimerization via Single-Molecule Microscopy Using New Antagonistic Fluorescent Probes J. Med. Chem. (IF 6.054) Pub Date : 2020-03-25 Antonios Drakopoulos; Zsombor Koszegi; Yann Lanoiselée; Harald Hübner; Peter Gmeiner; Davide Calebiro; Michael Decker
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TREK Channel Family Activator with a Well-Defined Structure–Activation Relationship for Pain and Neurogenic Inflammation J. Med. Chem. (IF 6.054) Pub Date : 2020-03-24 Yunguang Qiu; Lu Huang; Jie Fu; Chenxia Han; Jing Fang; Ping Liao; Zhuo Chen; Yiqing Mo; Peihua Sun; Daqing Liao; Linghui Yang; Jing Wang; Qiansen Zhang; Jin Liu; Feng Liu; Tingting Liu; Wei Huang; Huaiyu Yang; Ruotian Jiang
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Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase J. Med. Chem. (IF 6.054) Pub Date : 2020-03-23 Buyun Tang; Mykhaylo S. Frasinyuk; Vimbai M. Chikwana; Krishna K. Mahalingan; Cynthia A. Morgan; Dyann M. Segvich; Svitlana P. Bondarenko; Galyna P. Mrug; Przemyslaw Wyrebek; David S. Watt; Anna A. DePaoli-Roach; Peter J. Roach; Thomas D. Hurley
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Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor J. Med. Chem. (IF 6.054) Pub Date : 2020-03-20 Desirée Bartolini; Francesca De Franco; Pierangelo Torquato; Rita Marinelli; Bruno Cerra; Riccardo Ronchetti; Arne Schon; Francesca Fallarino; Antonella De Luca; Guido Bellezza; Ivana Ferri; Angelo Sidoni; William G. Walton; Samuel J. Pellock; Matthew R. Redinbo; Sridhar Mani; Roberto Pellicciari; Antimo Gioiello; Francesco Galli
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Automated De Novo Design in Medicinal Chemistry: Which Types of Chemistry Does a Generative Neural Network Learn? J. Med. Chem. (IF 6.054) Pub Date : 2020-03-20 Christoph Grebner; Hans Matter; Alleyn T. Plowright; Gerhard Hessler
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Structure–Activity Relationship of Antischistosomal Ozonide Carboxylic Acids J. Med. Chem. (IF 6.054) Pub Date : 2020-03-19 Jianbo Wu; Xiaofang Wang; Francis C. K. Chiu; Cécile Häberli; David M. Shackleford; Eileen Ryan; Sriraghavan Kamaraj; Vivek J. Bulbule; Alexander I. Wallick; Yuxiang Dong; Karen L. White; Paul H. Davis; Susan A. Charman; Jennifer Keiser; Jonathan L. Vennerstrom
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Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma J. Med. Chem. (IF 6.054) Pub Date : 2020-03-19 Joshua D. Hansen; Matthew Correa; Mark A. Nagy; Matt Alexander; Veronique Plantevin; Virginia Grant; Brandon Whitefield; Dehua Huang; Timothy Kercher; Roy Harris; Rama Krishna Narla; Jim Leisten; Yang Tang; Mehran Moghaddam; Katalin Ebinger; Joseph Piccotti; Courtney G. Havens; Brian Cathers; James Carmichael; Thomas Daniel; Rupert Vessey; Lawrence G. Hamann; Katerina Leftheris; Derek Mendy; Frans
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CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success? J. Med. Chem. (IF 6.054) Pub Date : 2020-03-19 Sarah Diab; Mingfeng Yu; Shudong Wang
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Structure–Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators J. Med. Chem. (IF 6.054) Pub Date : 2020-03-19 Elisabeth Rexen Ulven; Tezz Quon; Eugenia Sergeev; Natasja Barki; Matjaz Brvar; Brian D. Hudson; Palash Dutta; Anders Højgaard Hansen; Line Ø. Bielefeldt; Andrew B. Tobin; Christine J. McKenzie; Graeme Milligan; Trond Ulven
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Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown J. Med. Chem. (IF 6.054) Pub Date : 2020-03-19 Yu-Hui Jin; Meng-Chen Lu; Yan Wang; Wen-Xin Shan; Xuan-Yu Wang; Qi-Dong You; Zheng-Yu Jiang
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Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease J. Med. Chem. (IF 6.054) Pub Date : 2020-03-19 Sònia Abás; Sergio Rodríguez-Arévalo; Andrea Bagán; Christian Griñán-Ferré; Foteini Vasilopoulou; Iria Brocos-Mosquera; Carolina Muguruza; Belén Pérez; Elies Molins; F. Javier Luque; Pilar Pérez-Lozano; Steven de Jonghe; Dirk Daelemans; Lieve Naesens; José Brea; M. Isabel Loza; Elena Hernández-Hernández; Jesús A. García-Sevilla; M. Julia García-Fuster; Milica Radan; Teodora Djikic; Katarina Nikolic;
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Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells J. Med. Chem. (IF 6.054) Pub Date : 2020-03-18 Jussara Amato; Giulia Miglietta; Rita Morigi; Nunzia Iaccarino; Alessandra Locatelli; Alberto Leoni; Ettore Novellino; Bruno Pagano; Giovanni Capranico; Antonio Randazzo
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Discovery of Thieno[2,3-d]pyrimidine-Based Hydroxamic Acid Derivatives as Bromodomain-Containing Protein 4/Histone Deacetylase Dual Inhibitors Induce Autophagic Cell Death in Colorectal Carcinoma Cells J. Med. Chem. (IF 6.054) Pub Date : 2020-03-18 Zhaoping Pan; Xiang Li; Yujia Wang; Qinglin Jiang; Li Jiang; Min Zhang; Nan Zhang; Fengbo Wu; Bo Liu; Gu He
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Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity J. Med. Chem. (IF 6.054) Pub Date : 2020-03-17 Marta Serafini; Enza Torre; Silvio Aprile; Erika Del Grosso; Alessandro Gesù; Alessia Griglio; Giorgia Colombo; Cristina Travelli; Salvatore Paiella; Annalisa Adamo; Elena Orecchini; Alice Coletti; Maria Teresa Pallotta; Stefano Ugel; Alberto Massarotti; Tracey Pirali; Silvia Fallarini
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Metabolic and Pharmaceutical Aspects of Fluorinated Compounds J. Med. Chem. (IF 6.054) Pub Date : 2020-03-17 Benjamin M. Johnson; Yue-Zhong Shu; Xiaoliang Zhuo; Nicholas A. Meanwell
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Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe J. Med. Chem. (IF 6.054) Pub Date : 2020-03-16 Sonia Kołt; Tomasz Janiszewski; Dion Kaiserman; Sylwia Modrzycka; Scott J. Snipas; Guy Salvesen; Marcin Dra̧g; Phillip I. Bird; Paulina Kasperkiewicz
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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease J. Med. Chem. (IF 6.054) Pub Date : 2020-03-16 Kristi A. Leonard; Lisa A. Madge; Paul J. Krawczuk; Aihua Wang; Kevin D. Kreutter; Genesis M. Bacani; Wenying Chai; Russell C. Smith; Mark S. Tichenor; Michael C. Harris; Ravi Malaviya; Mark Seierstad; Marguerite E. Johnson; Jennifer D. Venable; Suzie Kim; Gavin C. Hirst; Ashok S. Mathur; Tadimeti S. Rao; James P. Edwards; Michele C. Rizzolio; Tatiana Koudriakova
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Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase J. Med. Chem. (IF 6.054) Pub Date : 2020-03-16 Yuta Tanaka; Osamu Kurasawa; Akihiro Yokota; Michael G. Klein; Koji Ono; Bunnai Saito; Shigemitsu Matsumoto; Masanori Okaniwa; Geza Ambrus-Aikelin; Daisuke Morishita; Satoshi Kitazawa; Noriko Uchiyama; Kazumasa Ogawa; Hiromichi Kimura; Shinichi Imamura
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Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain J. Med. Chem. (IF 6.054) Pub Date : 2020-03-13 Mitsuyasu Kawaguchi; Takayoshi Okabe; Shinichi Okudaira; Kotaro Hama; Kuniyuki Kano; Hiroshi Nishimasu; Hidehiko Nakagawa; Ryuichiro Ishitani; Hirotatsu Kojima; Osamu Nureki; Junken Aoki; Tetsuo Nagano
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A Physiologically Based in Silico Tool to Assess the Risk of Drug-Related Crystalluria J. Med. Chem. (IF 6.054) Pub Date : 2020-03-13 Zhenhong Li; John Litchfield; David A. Tess; Anthony A. Carlo; Heather Eng; Christopher Keefer; Tristan S. Maurer
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Discovery and SARs of 5-Chloro-N4-phenyl-N2-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors with Potent Antitumor Activity J. Med. Chem. (IF 6.054) Pub Date : 2020-03-12 Yang Wang; Xing Chen; Yaoyao Yan; Xiaochen Zhu; Mingming Liu; Xinhua Liu
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Bifunctional Molecules beyond PROTACs J. Med. Chem. (IF 6.054) Pub Date : 2020-03-11 Stuart J. Conway
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Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders J. Med. Chem. (IF 6.054) Pub Date : 2020-03-10 Xiaozheng Dou; Dinesh Nath; Henry Shin; Elmar Nurmemmedov; Philip C. Bourne; Jian-Xing Ma; Adam S. Duerfeldt
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Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease J. Med. Chem. (IF 6.054) Pub Date : 2020-03-05 Justin R. Harrison; Sandipan Sarkar; Shahienaz Hampton; Jennifer Riley; Laste Stojanovski; Christer Sahlberg; Pia Appelqvist; Jessey Erath; Vinodhini Mathan; Ana Rodriguez; Marcel Kaiser; Dolores Gonzalez Pacanowska; Kevin D. Read; Nils Gunnar Johansson; Ian H. Gilbert
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Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-26 Ling Tong,Wenping Li,Michael Man-Chu Lo,Xiaolei Gao,Jenny Miu-Chen Wai,Michael Rudd,David Tellers,Aniket Joshi,Zhizhen Zeng,Patricia Miller,Cristian Salinas,Kerry Riffel,Hyking Haley,Mona Purcell,Marie Holahan,Liza Gantert,Jeffrey W Schubert,Kristen Jones,James Mulhearn,Melissa Egbertson,Zhaoyang Meng,Barbara Hanney,Robert Gomez,Scott T Harrison,Paul McQuade,Tjerk Bueters,Jason Uslaner,John Morrow
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Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors. J. Med. Chem. (IF 6.054) Pub Date : 2020-03-02 Chelsea Massaro,Jenna Thomas,Houssine Ikhlef,Sharifa Dinara,Sara Cronk,Holly Moots,Otto Phanstiel
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Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-18 Sung Hu,Mariarosaria Ferraro,Ajesh P Thomas,Jeong Min Chung,Nam Gu Yoon,Ji-Hoon Seol,Sangpil Kim,Han-Ul Kim,Mi Young An,Haewon Ok,Hyun Suk Jung,Ja-Hyoung Ryu,Giorgio Colombo,Byoung Heon Kang
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Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-18 Irina N Gaisina,Norton P Peet,Han Cheng,Ping Li,Ruikun Du,Qinghua Cui,Kevin Furlong,Balaji Manicassamy,Michael Caffrey,Gregory R J Thatcher,Lijun Rong
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2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-11 Sanjay Bhattarai,Jan Pippel,Emma Scaletti,Riham Idris,Marianne Freundlieb,Georg Rolshoven,Christian Renn,Sang-Yong Lee,Aliaa Abdelrahman,Herbert Zimmermann,Ali El-Tayeb,Christa E Müller,Norbert Sträter
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Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-11 Jimin Xu,Judith Berastegui-Cabrera,Haiying Chen,Jerónimo Pachón,Jia Zhou,Javier Sánchez-Céspedes
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Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-18 Ya'nan Yu,Yuqiao Han,Fupo Zhang,Zhenmei Gao,Tong Zhu,Suzhen Dong,Mingliang Ma
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Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-17 Carley J S Heck,Herana Kamal Seneviratne,Namandjé N Bumpus
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Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-14 Sarah F Giardina,Douglas S Werner,Maneesh Pingle,Philip B Feinberg,Kenneth W Foreman,Donald E Bergstrom,Lee D Arnold,Francis Barany
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Structural Effect on Adjuvanticity of Saponins. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-26 Pengfei Wang,Xiong Ding,Hyunjung Kim,Suzanne M Michalek,Ping Zhang
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Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8 J. Med. Chem. (IF 6.054) Pub Date : 2020-02-25 Yuguang Zhao; Jingshan Ren; James Hillier; Weixian Lu; E. Yvonne Jones
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Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib J. Med. Chem. (IF 6.054) Pub Date : 2020-02-24 Greta Bagnolini; Domenico Milano; Marcella Manerba; Fabrizio Schipani; Jose Antonio Ortega; Dario Gioia; Federico Falchi; Andrea Balboni; Fulvia Farabegoli; Francesca De Franco; Janet Robertson; Roberto Pellicciari; Isabella Pallavicini; Sebastiano Peri; Saverio Minucci; Stefania Girotto; Giuseppina Di Stefano; Marinella Roberti; Andrea Cavalli
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α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-11 Linlin Zhang,Daizong Lin,Yuri Kusov,Yong Nian,Qingjun Ma,Jiang Wang,Albrecht von Brunn,Pieter Leyssen,Kristina Lanko,Johan Neyts,Adriaan de Wilde,Eric J Snijder,Hong Liu,Rolf Hilgenfeld
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Cutaneous Adverse Events Caused by Sulfonamide-Containing Drugs: Reality or Perception? J. Med. Chem. (IF 6.054) Pub Date : 2020-02-24 Falgun Shah; Ian M. Bell
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Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins? J. Med. Chem. (IF 6.054) Pub Date : 2020-02-24 Khang Ngo; Chelsey Collins-Kautz; Stefan Gerstenecker; Björn Wagner; Andreas Heine; Gerhard Klebe
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Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-06 Ramakrishna Nirogi,Abdul Rasheed Mohammed,Anil K Shinde,Srinivasa Rao Ravella,Narsimha Bogaraju,Ramkumar Subramanian,Venkat Reddy Mekala,Raghava Choudary Palacharla,Nageswararao Muddana,Jagadeesh Babu Thentu,Gopinadh Bhyrapuneni,Renny Abraham,Venkat Jasti
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Radiotracer Development for Bacterial Imaging. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-12 Filipa Mota,Alvaro A Ordonez,George Firth,Camilo A Ruiz-Bedoya,Michelle T Ma,Sanjay K Jain
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Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-21 Merrie Mosedale,Paul B Watkins
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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-21 Guo Li,Nicholas A Meanwell,Mark R Krystal,David R Langley,B Narasimhulu Naidu,Prasanna Sivaprakasam,Hal Lewis,Kevin Kish,Javed A Khan,Alicia Ng,George L Trainor,Christopher Cianci,Ira B Dicker,Michael A Walker,Zeyu Lin,Tricia Protack,Linda Discotto,Susan Jenkins,Samuel W Gerritz,Annapurna Pendri
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The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-21 Antimo Gioiello,Alessandro Piccinno,Anna Maria Lozza,Bruno Cerra
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Women in Medicinal Chemistry: Ad Maiora! J. Med. Chem. (IF 6.054) Pub Date : 2020-02-20 Maria Laura Bolognesi,Kelly L Ganamet,Hong Liu,Sally-Ann Poulsen,Gunda I Georg,Shaomeng Wang
This article is part of the Women in Medicinal Chemistry special issue. Journal of Medicinal Chemistry is proud to share the release of its first special issue dedicated to “Women in Medicinal Chemistry”, jointly published with ACS Medicinal Chemistry Letters. We were overwhelmed at the level of interest following the Call for Papers for this special issue.(1) The number of submissions received was
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The Other Angiotensin II Receptor: AT2R as a Therapeutic Target. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-07 Lucienne Juillerat-Jeanneret
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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133. J. Med. Chem. (IF 6.054) Pub Date : 2020-02-20 Yahu A Liu,Qihui Jin,Yefen Zou,Qiang Ding,Shanshan Yan,Zhicheng Wang,Xueshi Hao,Bao Nguyen,Xiaoyue Zhang,Jianfeng Pan,Tingting Mo,Kate Jacobsen,Thanh Lam,Tom Y-H Wu,H Michael Petrassi,Badry Bursulaya,Michael DiDonato,W Perry Gordon,Bo Liu,Janine Baaten,Robert Hill,Vân Nguyen-Tran,Minhua Qiu,You-Qing Zhang,Anwesh Kamireddy,Sheryll Espinola,Lisa Deaton,Sukwon Ha,George Harb,Yong Jia,Jing Li,Weijun Shen
Contents have been reproduced by permission of the publishers.
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