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Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration. Circulation (IF 37.8) Pub Date : 2023-10-31 Feng Gao,Tian Liang,Yao Wei Lu,Linbin Pu,Xuyang Fu,Xiaoxuan Dong,Tingting Hong,Feng Zhang,Ning Liu,Yuxia Zhou,Hongkun Wang,Ping Liang,Yuxuan Guo,Hong Yu,Wei Zhu,Xinyang Hu,Hong Chen,Bin Zhou,William T Pu,John D Mably,Jian'an Wang,Da-Zhi Wang,Jinghai Chen
BACKGROUND The importance of mitochondria in normal heart function are well recognized and recent studies have implicated changes in mitochondrial metabolism with some forms of heart disease. Previous studies demonstrated that knockdown of the mitochondrial ribosomal protein S5 (MRPS5) by small interfering RNA (siRNA) inhibits mitochondrial translation and thereby causes a mitonuclear protein imbalance
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Single-Cell Meta-Analysis of Neutrophil Activation in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children Reveals Potential Shared Immunological Drivers. Circulation (IF 37.8) Pub Date : 2023-10-31 Jan Vincent B Beltran,Fang-Ping Lin,Chaw-Liang Chang,Tai-Ming Ko
BACKGROUND Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) share similar clinical manifestations, including cardiovascular complications, suggesting similar underlying immunopathogenic processes. Aberrant neutrophil activation may play a crucial role in the shared pathologies of KD and MIS-C; however, the associated pathogenic mechanisms and molecular drivers remain
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ChaMP-CMD: A Phenotype-Blinded, Randomized Controlled, Cross-Over Trial. Circulation (IF 37.8) Pub Date : 2023-10-31 Aish Sinha,Haseeb Rahman,Abdel Douiri,Ozan M Demir,Kalpa De Silva,Brian Clapp,Ian Webb,Ankur Gulati,Pedro Pinho,Utkarsh Dutta,Howard Ellis,Ajay M Shah,Amedeo Chiribiri,Michael Marber,Andrew J Webb,Divaka Perera
BACKGROUND Angina with nonobstructive coronary arteries is a common condition for which no effective treatment has been established. We hypothesized that the measurement of coronary flow reserve (CFR) allows identification of patients with angina with nonobstructive coronary arteries who would benefit from anti-ischemic therapy. METHODS Patients with angina with nonobstructive coronary arteries underwent
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The Large Effect Size of Helen Hobbs: A Conversation With Helen Hobbs, MD. Circulation (IF 37.8) Pub Date : 2023-10-30 Maryjane Farr
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Letter by Teng et al Regarding the Article, "Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration". Circulation (IF 37.8) Pub Date : 2023-10-30 Zhenqing Teng,Bangdang Chen,Xiang Ma
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Excess Pericardial Fat Is Related to Adverse Cardio-Mechanical Interaction in Heart Failure With Preserved Ejection Fraction. Circulation (IF 37.8) Pub Date : 2023-10-30 Sauyeh K Zamani,Satyam Sarma,James P MacNamara,Linda S Hynan,Mark J Haykowsky,Christopher M Hearon,Denis Wakeham,Tiffany Brazile,Benjamin D Levine,Vlad G Zaha,Michael D Nelson
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Response by Luo and Ji to Letter Regarding Article, "Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration". Circulation (IF 37.8) Pub Date : 2023-10-30 Shanshan Luo,Yong Ji
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Next Generation, Modifiable Cardiometabolic Biomarkers: Mitochondrial Adaptation and Metabolic Resilience: A Scientific Statement From the American Heart Association. Circulation (IF 37.8) Pub Date : 2023-10-30 Michele Mietus-Snyder,Amanda M Perak,Susan Cheng,Laura L Hayman,Norrisa Haynes,Peter J Meikle,Svati H Shah,Shakira F Suglia,
Cardiometabolic risk is increasing in prevalence across the life span with disproportionate ramifications for youth at socioeconomic disadvantage. Established risk factors and associated disease progression are harder to reverse as they become entrenched over time; if current trends are unchecked, the consequences for individual and societal wellness will become untenable. Interrelated root causes
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Projected Change in the Burden of Excess Cardiovascular Deaths Associated With Extreme Heat by Midcentury (2036-2065) in the Contiguous United States. Circulation (IF 37.8) Pub Date : 2023-10-30 Sameed Ahmed M Khatana,Lauren A Eberly,Ashwin S Nathan,Peter W Groeneveld
BACKGROUND Climate change is causing an increase in extreme heat. Individuals with cardiovascular disease are at high risk of heat-related adverse health effects. How the burden of extreme heat-associated cardiovascular deaths in the United States will change with the projected rise in extreme heat is unknown. METHODS We obtained data on cardiovascular deaths among adults and the number of extreme
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MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy. Circulation (IF 37.8) Pub Date : 2023-10-27 Puneeth Shridhar,Michael S Glennon,Soumojit Pal,Christina J Waldron,Ethan J Chetkof,Payel Basak,Nicolas G Clavere,Dipanjan Banerjee,Sebastien Gingras,Jason R Becker
BACKGROUND Microvasculature dysfunction is a common finding in pathologic remodeling of the heart and is thought to play an important role in the pathogenesis of hypertrophic cardiomyopathy (HCM), a disease caused by sarcomere gene mutations. We hypothesized that microvascular dysfunction in HCM was secondary to abnormal microvascular growth and could occur independent of ventricular hypertrophy. METHODS
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Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair. Circulation (IF 37.8) Pub Date : 2023-10-27 Jie Feng,Yandong Li,Yan Li,Qianqian Yin,Haotong Li,Jun Li,Bin Zhou,Jian Meng,Hong Lian,Mengge Wu,Yahuan Li,Kefei Dou,Weihua Song,Bin Lu,Lihui Liu,Shengshou Hu,Yu Nie
BACKGROUND The adult mammalian heart is incapable of regeneration, whereas a transient regenerative capacity is maintained in the neonatal heart, primarily through the proliferation of preexisting cardiomyocytes. Neonatal heart regeneration after myocardial injury is accompanied by an expansion of cardiac fibroblasts and compositional changes in the extracellular matrix. Whether and how these changes
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Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure at 6 Months Following Medication Escalation: The RADIANCE Clinical Trial Program. Circulation (IF 37.8) Pub Date : 2023-10-26 Michel Azizi,Andrew S P Sharp,Naomi D L Fisher,Michael A Weber,Melvin D Lobo,Joost Daemen,Philipp Lurz,Felix Mahfoud,Roland E Schmieder,Jan Basile,Michael J Bloch,Manish Saxena,Yale Wang,Kintur Sanghvi,J Stephen Jenkins,Chandan Devireddy,Florian Rader,Philippe Gosse,Lisa Claude,Dimitri A Augustin,Candace K McClure,Ajay J Kirtane,
Background: The RADIANCE-HTN SOLO, RADIANCE-HTN TRIO, and RADIANCE II randomized, sham-controlled trials independently met their primary endpoint of a greater reduction in daytime ambulatory systolic blood pressure (SBP) at 2 months after ultrasound renal denervation (uRDN) in patients with hypertension. To characterize the longer-term effectiveness and safety of uRDN vs. sham at 6 months, following
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Stopping Aspirin Within 1 Month After Stenting for Ticagrelor Monotherapy in Acute Coronary Syndrome: The T-PASS Randomized Noninferiority Trial. Circulation (IF 37.8) Pub Date : 2023-10-25 Sung-Jin Hong,Seung-Jun Lee,Yongsung Suh,Kyeong Ho Yun,Tae Soo Kang,Sanghoon Shin,Sung Woo Kwon,Jun-Won Lee,Deok-Kyu Cho,Jong-Kwan Park,Jang-Whan Bae,Woong Cheol Kang,Seunghwan Kim,Yong-Joon Lee,Chul-Min Ahn,Jung-Sun Kim,Byeong-Keuk Kim,Young-Guk Ko,Donghoon Choi,Yangsoo Jang,Myeong-Ki Hong,
Background: Stopping aspirin within 1 month after implantation of a drug-eluting stent (DES) for ticagrelor monotherapy has not been exclusively evaluated for patients with acute coronary syndrome (ACS). The aim of this study was to investigate whether ticagrelor monotherapy after <1 month of dual antiplatelet therapy (DAPT) is noninferior to 12 months of ticagrelor-based DAPT for adverse cardiovascular
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Portfolio Diet Score and Risk of Cardiovascular Disease: Findings From 3 Prospective Cohort Studies. Circulation (IF 37.8) Pub Date : 2023-10-25 Andrea J Glenn,Marta Guasch-Ferré,Vasanti S Malik,Cyril W C Kendall,JoAnn E Manson,Eric B Rimm,Walter C Willett,Qi Sun,David J A Jenkins,Frank B Hu,John L Sievenpiper
BACKGROUND The plant-based Portfolio dietary pattern includes recognized cholesterol-lowering foods (ie, plant protein, nuts, viscous fiber, phytosterols, and plant monounsaturated fats) shown to improve several cardiovascular disease (CVD) risk factors in randomized controlled trials. However, there is limited evidence on the role of long-term adherence to the diet and CVD risk. The primary objective
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One-Year Outcomes After Amulet or Watchman Device for Percutaneous Left Atrial Appendage Closure: a Pre-Specified Analysis of the SWISS-APERO Randomized Clinical Trial. Circulation (IF 37.8) Pub Date : 2023-10-24 Roberto Galea,Nicolas Meneveau,Federico De Marco,Adel Aminian,Dik Heg,Konstantina Chalkou,Christoph Gräni,Frederic Anselme,Anna Franzone,Pascal Vranckx,Urs Fischer,Francesco Bedogni,Lorenz Räber,Marco Valgimigli
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Concomitant Left Atrial Appendage Occlusion and Transcatheter Aortic Valve Replacement Among Patients with Atrial Fibrillation. Circulation (IF 37.8) Pub Date : 2023-10-24 Samir R Kapadia,Amar Krishnaswamy,Brian Whisenant,Srinivasa Potluri,Vijay Iyer,Joseph Aragon,Philip Gideon,Justin Strote,Robert Leonardi,Himanshu Agarwal,German Larrain,Carlos Sanchez,Sidakpal S Panaich,James Harvey,Torsten Vahl,Venu Menon,Kathy Wolski,Qiuqing Wang,Martin B Leon
BACKGROUND Atrial fibrillation (AF) is common in patients undergoing transcatheter aortic valve replacement (TAVR) and is associated with increased risk of bleeding and stroke. While left atrial appendage occlusion (LAAO) is approved as an alternative to anticoagulants for stroke prevention in patients with AF, placement of these devices neither in patients with severe AS, nor at the same time as TAVR
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The Future of Cardiac Surgical Training in the Age of Transcatheter Valvular Interventions. Circulation (IF 37.8) Pub Date : 2023-10-23 Gry Dahle,Talal Al-Atassi,Tsuyoshi Kaneko
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Women in Cardiac Surgery: Closing the Equity Gap. Circulation (IF 37.8) Pub Date : 2023-10-23 Bobby Yanagawa,Marina Ibrahim,Jennifer Lawton
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Potential of Quantitative Flow Ratio for Selecting Target Vessels for Radial Artery Grafting: A Retrospective Observational Study. Circulation (IF 37.8) Pub Date : 2023-10-23 Zhan Hu,Chunyuan Wang,Xin Yuan,Siyu Zhang,Sipeng Chen,Zhihui Hou,Bo Xu,Lei Song,Yu Ning,Yan Zhang,Wei Feng
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Introduction to the 2023 Cardiovascular Surgery Issue. Circulation (IF 37.8) Pub Date : 2023-10-23 Marc Ruel,Michael P Fischbein,James A de Lemos
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Risk Factors for Reintervention With Functionally Single-Ventricle Disease Undergoing Staged Palliation in England and Wales: A Retrospective Cohort Study. Circulation (IF 37.8) Pub Date : 2023-10-23 Qi Huang,Deborah Ridout,Victor Tsang,Nigel E Drury,Timothy J Jones,Hannah Bellsham-Revell,Elena Hadjicosta,Anna N Seale,Chetan Mehta,Christina Pagel,Sonya Crowe,Ferran Espuny-Pujol,Rodney C G Franklin,Kate L Brown
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Safety and Efficacy of Ticagrelor Monotherapy in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: an Individual Patient Data Meta-analysis of TWILIGHT and TICO Randomized Trials. Circulation (IF 37.8) Pub Date : 2023-10-23 Usman Baber,Yangsoo Jang,Angelo Oliva,Davide Cao,Birgit Vogel,George Dangas,Samantha Sartori,Alessandro Spirito,Kenneth F Smith,Mattia Branca,Timothy Collier,Stuart Pocock,Marco Valgimigli,Byeong-Keuk Kim,Myeong-Ki Hong,Roxana Mehran
Background: Dual antiplatelet therapy (DAPT) with a potent P2Y12 Inhibitor coupled with aspirin for 1 year is the recommended treatment for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Alternatively, monotherapy with a P2Y12 inhibitor after a short period of DAPT has emerged as a bleeding reduction strategy. Methods: We pooled individual patient data
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Rivaroxaban Plus Aspirin Versus Aspirin Alone After Endovascular Revascularization for Symptomatic PAD: Insights From VOYAGER PAD. Circulation (IF 37.8) Pub Date : 2023-10-18 Jennifer Rymer,Sonia S Anand,E Sebastian Debus,Lloyd P Haskell,Connie N Hess,W Schuyler Jones,Eva Muehlhofer,Scott D Berkowitz,Rupert M Bauersachs,Marc P Bonaca,Manesh R Patel
BACKGROUND Rivaroxaban plus aspirin compared with aspirin alone reduced major cardiac and ischemic limb events after lower extremity revascularization (LER) in the VOYAGER PAD (Vascular Outcomes Study of ASA Along With Rivaroxaban in Endovascular or Surgical Limb Revascularization for Peripheral Artery Disease) trial. The effect has not been described in patients undergoing endovascular LER. METHODS
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Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics. Circulation (IF 37.8) Pub Date : 2023-10-18 Julius L Decano,Enrico Maiorino,Joan T Matamalas,Sarvesh Chelvanambi,Bart M Tiemeijer,Yoshihiro Yanagihara,Shin Mukai,Prabhash Kumar Jha,Diego V S Pestana,Edwin D'Souza,Mary Whelan,Rile Ge,Takaharu Asano,Amitabh Sharma,Peter Libby,Sasha A Singh,Elena Aikawa,Masanori Aikawa
BACKGROUND Interferon-γ (IFNγ) signaling plays a complex role in atherogenesis. IFNγ stimulation of macrophages permits in vitro exploration of proinflammatory mechanisms and the development of novel immune therapies. We hypothesized that the study of macrophage subpopulations could lead to anti-inflammatory interventions. METHODS Primary human macrophages activated by IFNγ (M(IFNγ)) underwent analyses
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Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-β-Blocking R-Enantiomer Carvedilol. Circulation (IF 37.8) Pub Date : 2023-10-18 Kinya Seo,Yuta Yamamoto,Anna Kirillova,Masataka Kawana,Sunil Yadav,Yong Huang,Qianru Wang,Kerry V Lane,Beth L Pruitt,Marco V Perez,Daniel Bernstein,Joseph C Wu,Matthew T Wheeler,Victoria N Parikh,Euan A Ashley
BACKGROUND Hypercontractility and arrhythmia are key pathophysiologic features of hypertrophic cardiomyopathy (HCM), the most common inherited heart disease. β-Adrenergic receptor antagonists (β-blockers) are the first-line therapy for HCM. However, β-blockers commonly selected for this disease are often poorly tolerated in patients, where heart-rate reduction and noncardiac effects can lead to reduced
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Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial. Circulation (IF 37.8) Pub Date : 2023-10-18 Min Chul Kim,Yongwhan Lim,Seung Hun Lee,Yoonmin Shin,Joon Ho Ahn,Dae Young Hyun,Kyung Hoon Cho,Doo Sun Sim,Young Joon Hong,Ju Han Kim,Myung Ho Jeong,Yong Hun Jung,In-Seok Jeong,Youngkeun Ahn
BACKGROUND Although venoarterial extracorporeal membrane oxygenation (VA-ECMO) is beneficial for the treatment of profound cardiogenic shock, peripheral VA-ECMO cannulation can increase left ventricular afterload, thus compromising myocardial recovery. We investigated whether early routine left ventricular unloading can reduce 30-day mortality compared with the conventional approach in patients with
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Efficacy, Safety, and Tolerability of Inclisiran in Patients With Homozygous Familial Hypercholesterolemia: Results From the ORION-5 Randomized Clinical Trial. Circulation (IF 37.8) Pub Date : 2023-10-18 Frederick Raal,Ronen Durst,Ran Bi,Zsolt Talloczy,Pierre Maheux,Anastasia Lesogor,John J P Kastelein,
BACKGROUND Homozygous familial hypercholesterolemia is a genetic disease characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C) and a high risk of premature cardiovascular events. Phase 2 of ORION (A Study of Inclisiran in Participants With Homozygous Familial Hypercholesterolemia) showed that inclisiran, a small interfering RNA that prevents production of the hepatic
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Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1. Circulation (IF 37.8) Pub Date : 2023-10-16 Jijun Huang,Josh Z Lee,Christoph D Rau,Arash Pezhouman,Tomohiro Yokota,Hiromi Miwa,Matthew Feldman,Tsz Kin Kong,Ziyue Yang,Woan Ting Tay,Ivan Pushkarsky,Kyungsoo Kim,Shan S Parikh,Shreya Udani,Boon Seng Soh,Chen Gao,Linsey Stiles,Orian S Shirihai,Bjorn C Knollmann,Reza Ardehali,Dino Di Carlo,Yibin Wang
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Sphingolipid Signaling Takes Center Stage in Regulation of Lymphatic-Immune Crosstalk in Lymphedema. Circulation (IF 37.8) Pub Date : 2023-10-16 Ebba Brakenhielm
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A Unique Case of Right Axis Deviation. Circulation (IF 37.8) Pub Date : 2023-10-16 Patrick E O'Hara,Vishnu Venkatesh,Hannah Lehrenbaum
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Effects of Synchronizing Foot Strike and Cardiac Phase on Exercise Hemodynamics in Patients With Cardiac Resynchronization Therapy: A Within-Subjects Pilot Study to Fine-Tune Cardio-Locomotor Coupling for Heart Failure. Circulation (IF 37.8) Pub Date : 2023-10-13 Denis J Wakeham,Erika Ivey,Sophie Saland,Joshua Lewis,Dean Palmer,Margot Morris,Jeffery L Bleich,Peter G Weyand,Tiffany L Brazile,Christopher M Hearon,Satyam Sarma,James P MacNamara,Michinari Hieda,Benjamin D Levine
BACKGROUND Despite advances in medical and cardiac resynchronization therapy (CRT), individuals with chronic congestive heart failure (CHF) have persistent symptoms, including exercise intolerance. Optimizing cardio-locomotor coupling may increase stroke volume and skeletal muscle perfusion as previously shown in healthy runners. Therefore, we tested the hypothesis that exercise stroke volume and cardiac
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Dapagliflozin and Apparent Treatment-Resistant Hypertension in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The DELIVER Trial. Circulation (IF 37.8) Pub Date : 2023-10-13 John W Ostrominski,Muthiah Vaduganathan,Senthil Selvaraj,Brian L Claggett,Zi Michael Miao,Akshay S Desai,Pardeep S Jhund,Mikhail N Kosiborod,Carolyn S P Lam,Silvio E Inzucchi,Felipe A Martinez,Rudolf A de Boer,Adrian F Hernandez,Sanjiv J Shah,Magnus Petersson,Anna Maria Langkilde,John J V McMurray,Scott D Solomon
BACKGROUND Apparent treatment-resistant hypertension (aTRH) is prevalent and associated with adverse outcomes in heart failure with mildly reduced or preserved ejection fraction. Less is known about the potential role of sodium-glucose co-transporter 2 inhibition in this high-risk population. In this post hoc analysis of the DELIVER trial (Dapagliflozin Evaluation to Improve the Lives of Patients with
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Comparative Discrimination of Life's Simple 7 and Life's Essential 8 to Stratify Cardiovascular Risk: Is the Added Complexity Worth It? Circulation (IF 37.8) Pub Date : 2023-10-13 George Howard,Mary Cushman,Jessica Blair,Nicole R Wilson,Ya Yuan,Monika M Safford,Emily B Levitan,Suzanne E Judd,Virginia J Howard
BACKGROUND Life's Simple 7 (LS7) is an easily calculated and interpreted metric of cardiovascular health based on 7 domains: smoking, diet, physical activity, body mass index, blood pressure, cholesterol, and fasting glucose. The Life's Essential 8 (LE8) metric was subsequently introduced, adding sleep metrics and revisions of the previous 7 domains. Although calculating LE8 requires additional information
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Asymptomatic Patients With Brugada ECG Pattern: Long-Term Prognosis From a Large Prospective Study. Circulation (IF 37.8) Pub Date : 2023-10-13 Fiorenzo Gaita,Natascia Cerrato,Carla Giustetto,Annamaria Martino,Laura Bergamasco,Michele Millesimo,Lorella Barbonaglia,Paula Carvalho,Domenico Caponi,Andrea Saglietto,Giacomo Bonacchi,Francesca Bianchi,Elisa Silvetti,Cinzia Crescenzi,Stefano Canestrelli,Melissa De Maio,Gaetano Maria De Ferrari,Giuseppe Musumeci,Francesco Rametta,Marco Scaglione,Leonardo Calò
BACKGROUND Brugada syndrome poses significant challenges in terms of risk stratification and management, particularly for asymptomatic patients who comprise the majority of individuals exhibiting Brugada ECG pattern (BrECG). The aim of this study was to evaluate the long-term prognosis of a large cohort of asymptomatic patients with BrECG. METHODS Asymptomatic patients with BrECG (1149) were consecutively
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Cardiac Troponins for Diagnosis and Prognostic Assessment of Immune Checkpoint Inhibitor Myocarditis and Myositis: The Emerging Importance of Peripheral Vision. Circulation (IF 37.8) Pub Date : 2023-10-09 Christopher deFilippi,Ana Barac
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Implantable Cardioverter Defibrillator in Patients With Nonischemic Systolic Heart Failure With and Without Cardiac Resynchronization Therapy: Extended Follow-Up Study of the DANISH Trial. Circulation (IF 37.8) Pub Date : 2023-10-09 Jawad H Butt,Adelina Yafasova,Seiko N Doi,Jens C Nielsen,Jens Haarbo,Hans Eiskjær,Axel Brandes,Anna M Thøgersen,Finn Gustafsson,Christian Hassager,Jesper H Svendsen,Dan E Høfsten,Lars Videbæk,Christian Torp-Pedersen,Steen Pehrson,Jens Jakob Thune,Lars Køber
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Letter by Krisai et al Regarding Article, "Pulsed Field Ablation for the Treatment of Atrial Fibrillation: PULSED AF Pivotal Trial". Circulation (IF 37.8) Pub Date : 2023-10-09 Philipp Krisai,Michael Kühne,Christian Sticherling
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Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association. Circulation (IF 37.8) Pub Date : 2023-10-09 Chiadi E Ndumele,Janani Rangaswami,Sheryl L Chow,Ian J Neeland,Katherine R Tuttle,Sadiya S Khan,Josef Coresh,Roy O Mathew,Carissa M Baker-Smith,Mercedes R Carnethon,Jean-Pierre Despres,Jennifer E Ho,Joshua J Joseph,Walter N Kernan,Amit Khera,Mikhail N Kosiborod,Carolyn L Lekavich,Eldrin F Lewis,Kevin B Lo,Bige Ozkan,Latha P Palaniappan,Sonali S Patel,Michael J Pencina,Tiffany M Powell-Wiley,Laurence
Cardiovascular-kidney-metabolic health reflects the interplay among metabolic risk factors, chronic kidney disease, and the cardiovascular system and has profound impacts on morbidity and mortality. There are multisystem consequences of poor cardiovascular-kidney-metabolic health, with the most significant clinical impact being the high associated incidence of cardiovascular disease events and cardiovascular
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A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association. Circulation (IF 37.8) Pub Date : 2023-10-09 Chiadi E Ndumele,Ian J Neeland,Katherine R Tuttle,Sheryl L Chow,Roy O Mathew,Sadiya S Khan,Josef Coresh,Carissa M Baker-Smith,Mercedes R Carnethon,Jean-Pierre Després,Jennifer E Ho,Joshua J Joseph,Walter N Kernan,Amit Khera,Mikhail N Kosiborod,Carolyn L Lekavich,Eldrin F Lewis,Kevin B Lo,Bige Ozkan,Latha P Palaniappan,Sonali S Patel,Michael J Pencina,Tiffany M Powell-Wiley,Laurence S Sperling,Salim
A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led to the conceptualization of cardiovascular-kidney-metabolic syndrome. The confluence of metabolic risk factors and chronic kidney disease within cardiovascular-kidney-metabolic syndrome is strongly linked to risk for adverse
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Nondental Invasive Procedures and Risk of Infective Endocarditis: Time for a Revisit: A Science Advisory From the American Heart Association. Circulation (IF 37.8) Pub Date : 2023-10-05 Larry M Baddour,Imre Janszky,Martin H Thornhill,Zerelda Esquer Garrigos,Daniel C DeSimone,Karen Welty-Wolf,Annette L Baker,Pei-Ni Jone,Bernard Prendergast,Mark J Dayer,
There have been no published prospective randomized clinical trials that have: (1) established an association between invasive dental and nondental invasive procedures and risk of infective endocarditis; or (2) defined the efficacy and safety of antibiotic prophylaxis administered in the setting of invasive procedures in the prevention of infective endocarditis in high-risk patients. Moreover, previous
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Invasive Endotyping in Patients With Angina and No Obstructive Coronary Artery Disease: A Randomized Controlled Trial. Circulation (IF 37.8) Pub Date : 2023-10-05 Novalia P Sidik,Bethany Stanley,Robert Sykes,Andrew J Morrow,Conor P Bradley,Michael McDermott,Thomas J Ford,Giles Roditi,Allister Hargreaves,David Stobo,Jacqueline Adams,John Byrne,Ahmed Mahrous,Robin Young,David Carrick,Ross McGeoch,David Corcoran,Ninian N Lang,Robert Heggie,Olivia Wu,Margaret B McEntegart,Alex McConnachie,Colin Berry
BACKGROUND We investigated the usefulness of invasive coronary function testing to diagnose the cause of angina in patients with no obstructive coronary arteries. METHODS Outpatients referred for coronary computed tomography angiography in 3 hospitals in the United Kingdom were prospectively screened. After coronary computed tomography angiography, patients with unobstructed coronary arteries, and
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Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study. Circulation (IF 37.8) Pub Date : 2023-10-05 Caren S Goldberg,Felicia Trachtenberg,J William Gaynor,William T Mahle,Chitra Ravishankar,Steven M Schwartz,James F Cnota,Richard G Ohye,Russell Gongwer,Michael Taylor,Stephen Paridon,Peter C Frommelt,Katherine Afton,Andrew M Atz,Kristin M Burns,Jon A Detterich,Kevin D Hill,Antonio G Cabrera,Alan B Lewis,Christian Pizarro,Amee Shah,Binu Sharma,Jane W Newburger,
OBJECTIVE In the SVR trial (Single Ventricle Reconstruction), newborns with hypoplastic left heart syndrome were randomly assigned to receive a modified Blalock-Taussig-Thomas shunt (mBTTS) or a right ventricle-to-pulmonary artery shunt (RVPAS) at Norwood operation. Transplant-free survival was superior in the RVPAS group at 1 year, but no longer differed by treatment group at 6 years; both treatment
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Blood Pressure and Oxygen Targets on Kidney Injury After Cardiac Arrest. Circulation (IF 37.8) Pub Date : 2023-10-04 Sebastian Buhl Rasmussen,Karoline Korsholm Jeppesen,Jesper Kjaergaard,Christian Hassager,Henrik Schmidt,Simon Mølstrøm,Rasmus Paulin Beske,Johannes Grand,Hanne Berg Ravn,Matilde Winther-Jensen,Martin Abild Stengaard Meyer,Jacob Eifer Møller
BACKGROUND Acute kidney injury (AKI) represents a common and serious complication to out-of-hospital cardiac arrest. The importance of post-resuscitation care targets for blood pressure and oxygenation for the development of AKI is unknown. METHODS This is a substudy of a randomized 2-by-2 factorial trial, in which 789 comatose adult patients who had out-of-hospital cardiac arrest with presumed cardiac
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Value-Based Payment for Cardiovascular Care: Getting to the Heart of the Matter. Circulation (IF 37.8) Pub Date : 2023-10-02 Rishi K Wadhera
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Standardized Definitions for Cardiogenic Shock Research and Mechanical Circulatory Support Devices: Scientific Expert Panel From the Shock Academic Research Consortium (SHARC). Circulation (IF 37.8) Pub Date : 2023-10-02 Ron Waksman,Mohit Pahuja,Sean van Diepen,Alastair G Proudfoot,David Morrow,Ernest Spitzer,Graham Nichol,Myron L Weisfeldt,Mauro Moscucci,Patrick R Lawler,Alexandre Mebazaa,Eddy Fan,Neal W Dickert,Marc Samsky,Robert Kormos,Ileana L Piña,Bram Zuckerman,Andrew Farb,John S Sapirstein,Charles Simonton,Nick E J West,Abdulla A Damluji,Ian C Gilchrist,Uwe Zeymer,Holger Thiele,Donald E Cutlip,Mitchell Krucoff
The Shock Academic Research Consortium is a multi-stakeholder group, including representatives from the US Food and Drug Administration and other government agencies, industry, and payers, convened to develop pragmatic consensus definitions useful for the evaluation of clinical trials enrolling patients with cardiogenic shock, including trials evaluating mechanical circulatory support devices. Several
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The Time to Initiate Anti-Inflammatory Therapy for Patients With Chronic Coronary Atherosclerosis Has Arrived. Circulation (IF 37.8) Pub Date : 2023-10-02 Paul M Ridker
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Bleeding and Myocardial Infarction in Acquired Factor VIII Deficiency. Circulation (IF 37.8) Pub Date : 2023-10-02 Joseph M Kim,Robert M Stern,Bradley A Maron
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BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis. Circulation (IF 37.8) Pub Date : 2023-10-02 Mustafa Yalcinkaya,Wenli Liu,Leigh-Anne Thomas,Malgorzata Olszewska,Tong Xiao,Sandra Abramowicz,Eirini P Papapetrou,Marit Westerterp,Nan Wang,Ira Tabas,Alan R Tall
BACKGROUND Clonal hematopoiesis (CH) has emerged as an independent risk factor for atherosclerotic cardiovascular disease, with activation of macrophage inflammasomes as a potential underlying mechanism. The NLRP3 (NLR family pyrin domain containing 3) inflammasome has a key role in promoting atherosclerosis in mouse models of Tet2 CH, whereas inhibition of the inflammasome product interleukin-1β appeared
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Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation (IF 37.8) Pub Date : 2023-10-02 Kim G Smolderen,Zainab Samaan,Carole Decker,Tracie Collins,Ronald M Lazar,Nathan K Itoga,Carlos Mena-Hurtado,
Along with the rising burden of peripheral artery disease (PAD), mental health concerns are increasingly being recognized as a comorbidity to address in the chronic disease management of symptomatic PAD. Apart from a high prevalence of comorbid mental health conditions, the role of pain and changing health behaviors and the broader impacts of illness and adaptation to living with PAD require specialized
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Computed Tomography Cardiac Angiography Before Invasive Coronary Angiography in Patients With Previous Bypass Surgery: The BYPASS-CTCA Trial. Circulation (IF 37.8) Pub Date : 2023-09-29 Daniel A Jones,Anne-Marie Beirne,Matthew Kelham,Krishnaraj S Rathod,Mervyn Andiapen,Lucinda Wynne,Thomas Godec,Nasim Forooghi,Rohini Ramaseshan,James C Moon,Ceri Davies,Christos V Bourantas,Andreas Baumbach,Charlotte Manisty,Andrew Wragg,Amrita Ahluwalia,Francesca Pugliese,Anthony Mathur,
BACKGROUND Patients with previous coronary artery bypass grafting often require invasive coronary angiography (ICA). However, for these patients, the procedure is technically more challenging and has a higher risk of complications. Observational studies suggest that computed tomography cardiac angiography (CTCA) may facilitate ICA in this group, but this has not been tested in a randomized controlled
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An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract. Circulation (IF 37.8) Pub Date : 2023-09-29 Naoko Yamaguchi,Ernest W Chang,Ziyan Lin,Akshay Shekhar,Lei Bu,Alireza Khodadadi-Jamayran,Aristotelis Tsirigos,Yiyun Cen,Colin K L Phoon,Ivan P Moskowitz,David S Park
BACKGROUND Conotruncal defects due to developmental abnormalities of the outflow tract (OFT) are an important cause of cyanotic congenital heart disease. Dysregulation of transcriptional programs tuned by NKX2-5 (NK2 homeobox 5), GATA6 (GATA binding protein 6), and TBX1 (T-box transcription factor 1) have been implicated in abnormal OFT morphogenesis. However, there remains no consensus on how these
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Food Is Medicine: A Presidential Advisory From the American Heart Association. Circulation (IF 37.8) Pub Date : 2023-09-28 Kevin G Volpp,Seth A Berkowitz,Shreela V Sharma,Cheryl A M Anderson,LaPrincess C Brewer,Mitchell S V Elkind,Christopher D Gardner,Julie E Gervis,Robert A Harrington,Mario Herrero,Alice H Lichtenstein,Mark McClellan,Jen Muse,Christina A Roberto,Justin P V Zachariah,
Unhealthy diets are a major impediment to achieving a healthier population in the United States. Although there is a relatively clear sense of what constitutes a healthy diet, most of the US population does not eat healthy food at rates consistent with the recommended clinical guidelines. An abundance of barriers, including food and nutrition insecurity, how food is marketed and advertised, access
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Shifting Power Dynamics in Nation's Capital Create Uncertainty for Medical Research. Circulation (IF 37.8) Pub Date : 2023-09-25 Cheryl Pegus,John Laughner
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Response by Pérez de Isla et al to Letter Regarding Article, "Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients With Familial Hypercholesterolemia: The ARCHITECT Study". Circulation (IF 37.8) Pub Date : 2023-09-25 Leopoldo Pérez de Isla,Adriana Saltijeral Cerezo,Pedro Mata
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Statin Reduces Heart Disease Risk in Patients With HIV. Circulation (IF 37.8) Pub Date : 2023-09-25 Bridget M Kuehn
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Expanding the Paradigm for Cardiovascular Palliative Care. Circulation (IF 37.8) Pub Date : 2023-09-25 Sarah Godfrey,James N Kirkpatrick,Daniel B Kramer,Melanie S Sulistio
Cardiovascular disease (CVD) is the leading cause of death worldwide. Despite medical advances, patients with CVD experience high morbidity and mortality rates, affecting their quality of life and death. Among CVD conditions, palliative care has been studied mostly in patients with heart failure, where palliative care interventions have been associated with improvements in patient-centered outcomes
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Letter by Long and Jiang Regarding Article, "Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients With Familial Hypercholesterolemia: The ARCHITECT Study". Circulation (IF 37.8) Pub Date : 2023-09-25 Xingqing Long,Mingyang Jiang
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Association Between Type 2 Diabetes and Changes in Myocardial Structure, Contractile Function, Energetics, and Blood Flow Before and After Aortic Valve Replacement in Patients With Severe Aortic Stenosis. Circulation (IF 37.8) Pub Date : 2023-09-25 Nicholas Jex,John P Greenwood,Richard M Cubbon,Oliver J Rider,Amrit Chowdhary,Sharmaine Thirunavukarasu,Sindhoora Kotha,Marilena Giannoudi,Anna McGrane,Amanda Maccannell,Marcella Conning-Rowland,Sam Straw,Henry Procter,Sotiris Papaspyros,Betsy Evans,Kalyana Javangula,Antonella Ferrara,Walid Elmahdy,Pankaj Kaul,Hui Xue,Peter Swoboda,Peter Kellman,Ladislav Valkovič,Lee Roberts,David Beech,Mark T Kearney
BACKGROUND Type 2 diabetes (T2D) is associated with an increased risk of left ventricular dysfunction after aortic valve replacement (AVR) in patients with severe aortic stenosis (AS). Persistent impairments in myocardial energetics and myocardial blood flow (MBF) may underpin this observation. Using phosphorus magnetic resonance spectroscopy and cardiovascular magnetic resonance, this study tested
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Bivalirudin Versus Heparin During PCI in NSTEMI: Individual Patient Data Meta-Analysis of Large Randomized Trials. Circulation (IF 37.8) Pub Date : 2023-09-25 Behnood Bikdeli,David Erlinge,Marco Valgimigli,Adnan Kastrati,Yaling Han,Philippe Gabriel Steg,Rod H Stables,Roxana Mehran,Stefan K James,Enrico Frigoli,Patrick Goldstein,Yi Li,Adeel Shahzad,Stefanie Schüpke,Ghazaleh Mehdipoor,Shmuel Chen,Björn Redfors,Aaron Crowley,Zhipeng Zhou,Gregg W Stone
BACKGROUND The benefit:risk profile of bivalirudin versus heparin anticoagulation in patients with non-ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) is uncertain. Study-level meta-analyses lack granularity to provide conclusive answers. We sought to compare the outcomes of bivalirudin and heparin in patients with non-ST-segment-elevation myocardial infarction
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Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates. Circulation (IF 37.8) Pub Date : 2023-09-21 Yu-Che Cheng,Marvin L Hsieh,Chen-Ju Lin,Cindy M C Chang,Ching-Ying Huang,Riley Puntney,Amy Wu Moy,Chien-Yu Ting,Darien Zhing Herr Chan,Martin W Nicholson,Po-Ju Lin,Hung-Chih Chen,Gina C Kim,Jianhua Zhang,Jennifer Coonen,Puja Basu,Heather A Simmons,Yen-Wen Liu,Timothy A Hacker,Timothy J Kamp,Patrick C H Hsieh
BACKGROUND Remuscularization of the mammalian heart can be achieved after cell transplantation of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs). However, several hurdles remain before implementation into clinical practice. Poor survival of the implanted cells is related to insufficient vascularization, and the potential for fatal arrhythmogenesis is associated with the fetal