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In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. Circulation (IF 39.918) Pub Date : 2023-01-27 Yangpo Cao,Xiaoran Zhang,Brynn N Akerberg,Haiyun Yuan,Tomoya Sakamoto,Feng Xiao,Nathan J VanDusen,Pingzhu Zhou,Mason E Sweat,Yi Wang,Maksymilian Prondzynski,Jian Chen,Yan Zhang,Peizhe Wang,Daniel P Kelly,William T Pu
BACKGROUND Cardiac chamber-selective transcriptional programs underpin the structural and functional differences between atrial and ventricular cardiomyocytes (aCMs and vCMs). The mechanisms responsible for these chamber-selective transcriptional programs remain largely undefined. METHODS We nominated candidate chamber-selective enhancers (CSEs) by determining the genome-wide occupancy of 7 key cardiac
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Myocardial Involvement After Hospitalization for COVID-19 Complicated by Troponin Elevation: A Prospective, Multicenter, Observational Study. Circulation (IF 39.918) Pub Date : 2023-01-27 Jessica Artico,Hunain Shiwani,James C Moon,Miroslawa Gorecka,Gerry P McCann,Giles Roditi,Andrew Morrow,Kenneth Mangion,Elena Lukaschuk,Mayooran Shanmuganathan,Christopher A Miller,Amedeo Chiribiri,Sanjay K Prasad,Robert D Adam,Trisha Singh,Chiara Bucciarelli-Ducci,Dana Dawson,Daniel Knight,Marianna Fontana,Charlotte Manisty,Thomas A Treibel,Eylem Levelt,Ranjit Arnold,Peter W Macfarlane,Robin Young
BACKGROUND Acute myocardial injury in hospitalized patients with coronavirus disease 2019 (COVID-19) has a poor prognosis. Its associations and pathogenesis are unclear. Our aim was to assess the presence, nature, and extent of myocardial damage in hospitalized patients with troponin elevation. METHODS Across 25 hospitals in the United Kingdom, 342 patients with COVID-19 and an elevated troponin level
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Cardiac Resynchronization Therapy Improves Outcomes in Patients With Intraventricular Conduction Delay But Not Right Bundle Branch Block: A Patient-Level Meta-Analysis of Randomized Controlled Trials. Circulation (IF 39.918) Pub Date : 2023-01-26 Daniel J Friedman,Sana M Al-Khatib,Frederik Dalgaard,Marat Fudim,William T Abraham,John G F Cleland,Anne B Curtis,Michael R Gold,Valentina Kutyifa,Cecilia Linde,Anthony S Tang,Fatima Ali-Ahmed,Antonio Olivas-Martinez,Lurdes Y T Inoue,Gillian D Sanders
BACKGROUND Benefit from cardiac resynchronization therapy (CRT) varies by QRS characteristics; individual randomized trials are underpowered to assess benefit for relatively small subgroups. METHODS The authors analyzed patient-level data from pivotal CRT trials (MIRACLE [Multicenter InSync Randomized Clinical Evaluation], MIRACLE-ICD [Multicenter InSync ICD Randomized Clinical Evaluation], MIRACLE-ICD
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Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes. Circulation (IF 39.918) Pub Date : 2023-01-25 Nans Florens,Rajesh K Kasam,Valeria Rudman-Melnick,Suh-Chin Lin,Vikram Prasad,Jeffery D Molkentin
BACKGROUND Acute kidney injury (AKI) is a short-term life-threatening condition that, if survived, can lead to renal insufficiency and development of chronic kidney disease. The pathogenesis of AKI and chronic kidney disease involves direct effects on the heart and the development of hypertrophy and cardiomyopathy. METHODS We used mouse models of ischemia/reperfusion AKI and unilateral ureteral obstruction
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Letter by Gutmann et al Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles". Circulation (IF 39.918) Pub Date : 2023-01-23 Clemens Gutmann,Stefan Stojkovic,Manuel Mayr
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Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank. Circulation (IF 39.918) Pub Date : 2023-01-23 Caitlyn Vlasschaert,J Brett Heimlich,Michael J Rauh,Pradeep Natarajan,Alexander G Bick
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Letter by Li et al Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles". Circulation (IF 39.918) Pub Date : 2023-01-23 Qi Li,Zhuqing Li,Chengzhi Lu
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Letter by Halushka and Witwer Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles". Circulation (IF 39.918) Pub Date : 2023-01-23 Marc K Halushka,Kenneth W Witwer
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Integrated Sudden Cardiac Death Risk Prediction Model For Patients With Hypertrophic Cardiomyopathy. Circulation (IF 39.918) Pub Date : 2023-01-23 Emanuele Monda,Giuseppe Limongelli
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Ralph L. Sacco, 65, Dies: Stroke Expert With a Talent for Architectural Design. Circulation (IF 39.918) Pub Date : 2023-01-17 Orly Avitzur
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Correction to: A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve. Circulation (IF 39.918) Pub Date : 2023-01-17
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A New Era in Cardiac Rehabilitation Delivery: Research Gaps, Questions, Strategies, and Priorities. Circulation (IF 39.918) Pub Date : 2023-01-17 Alexis L Beatty,Theresa M Beckie,John Dodson,Carly M Goldstein,Joel W Hughes,William E Kraus,Seth S Martin,Thomas P Olson,Quinn R Pack,Haley Stolp,Randal J Thomas,Wen-Chih Wu,Barry A Franklin
Cardiac rehabilitation (CR) is a guideline-recommended, multidisciplinary program of exercise training, risk factor management, and psychosocial counseling for people with cardiovascular disease (CVD) that is beneficial but underused and with substantial disparities in referral, access, and participation. The emergence of new virtual and remote delivery models has the potential to improve access to
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ECG Challenge: AV Block or Something Else? Circulation (IF 39.918) Pub Date : 2023-01-17 Leila Haghighat,Nora Goldschlager,Adam Oesterle
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Models for Evidence Generation During the COVID-19 Pandemic: New Opportunities for Clinical Trials in Cardiovascular Medicine. Circulation (IF 39.918) Pub Date : 2023-01-17 Patrick R Lawler
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Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2. Circulation (IF 39.918) Pub Date : 2023-01-17 Sha Chen,Qian Wang,Andriana Christodoulou,Nikolaos Mylonas,Diane Bakker,Rianne Nederlof,Markus W Hollmann,Nina C Weber,Ruben Coronel,Vincent Wakker,Vincent M Christoffels,Ioanna Andreadou,Coert J Zuurbier
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Cardiac Reprogramming: Toward a Total Eclipse of the Failing Heart. Circulation (IF 39.918) Pub Date : 2023-01-17 Glynnis A Garry,Eric N Olson
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Centering Patient Voices Through Community Engagement in Cardiovascular Research. Circulation (IF 39.918) Pub Date : 2023-01-09 Tiffany M Powell-Wiley
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What Is the Truth Behind Abnormal ECG Changes? Circulation (IF 39.918) Pub Date : 2023-01-09 Zhangli Yang,Chuan-Hai Zhang,Xuanxuan Li
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Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct. Circulation (IF 39.918) Pub Date : 2023-01-09 Zhe Yu,Lunfeng Zhang,Paola Cattaneo,Nuno Guimarães-Camboa,Xi Fang,Yusu Gu,Kirk L Peterson,Julius Bogomolovas,Cecilia Cuitino,Gustavo W Leone,Ju Chen,Sylvia M Evans
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Long-Term P2Y12 Inhibitor or Aspirin as Single Antiplatelet Therapy in Patients With Previous Percutaneous Coronary Intervention. Circulation (IF 39.918) Pub Date : 2023-01-09 Davide Capodanno,Dominick J Angiolillo
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A Tedious Journey: Cardiomyocyte Proliferation Requires More Than S-Phase Entry and Loss of Polyploidization. Circulation (IF 39.918) Pub Date : 2023-01-09 Dong Ding,Thomas Braun
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Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry. Circulation (IF 39.918) Pub Date : 2023-01-09 Martin Bødtker Mortensen,Omar Dzaye,Hans Erik Bøtker,Jesper Møller Jensen,Michael Maeng,Jacob Fog Bentzen,Helle Kanstrup,Henrik Toft Sørensen,Jonathon Leipsic,Ron Blankstein,Khurram Nasir,Michael J Blaha,Bjarne Linde Nørgaard
BACKGROUND Low-density lipoprotein cholesterol (LDL-C) is an important causal risk factor for atherosclerotic cardiovascular disease (ASCVD). However, a sizable proportion of middle-aged individuals with elevated LDL-C level have not developed coronary atherosclerosis as assessed by coronary artery calcification (CAC). Whether presence of CAC modifies the association of LDL-C with ASCVD risk is unknown
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Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis. Circulation (IF 39.918) Pub Date : 2023-01-04 Lael M Yonker,Zoe Swank,Yannic C Bartsch,Madeleine D Burns,Abigail Kane,Brittany P Boribong,Jameson P Davis,Maggie Loiselle,Tanya Novak,Yasmeen Senussi,Chi-An Cheng,Eleanor Burgess,Andrea G Edlow,Janet Chou,Audrey Dionne,Duraisamy Balaguru,Manuella Lahoud-Rahme,Moshe Arditi,Boris Julg,Adrienne G Randolph,Galit Alter,Alessio Fasano,David R Walt
BACKGROUND Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail. METHODS From January 2021 through February 2022, we prospectively collected blood from 16 patients who
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Exercise Volume Versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings From the MARC-2 Study. Circulation (IF 39.918) Pub Date : 2023-01-04 Vincent L Aengevaeren,Arend Mosterd,Esmée A Bakker,Thijs L Braber,Hendrik M Nathoe,Sanjay Sharma,Paul D Thompson,Birgitta K Velthuis,Thijs M H Eijsvogels
BACKGROUND Physical activity and exercise training are associated with a lower risk for coronary events. However, cross-sectional studies in middle-aged and older male athletes revealed increased coronary artery calcification (CAC) and atherosclerotic plaques, which were related to the amount and intensity of lifelong exercise. We examined the longitudinal relationship between exercise training characteristics
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Targeting Epsins to Inhibit Fibroblast Growth Factor Signaling While Potentiating Transforming Growth Factor-β Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis Circulation (IF 39.918) Pub Date : 2023-01-02 Yunzhou Dong, Beibei Wang, Mulong Du, Bo Zhu, Kui Cui, Kathryn Li, Ke Yuan, Douglas B. Cowan, Sudarshan Bhattacharjee, Scott Wong, Jinjun Shi, Da-Zhi Wang, Kaifu Chen, Joyce Bischoff, MacRae F. Linton, Hong Chen
BACKGROUND:Epsin endocytic adaptor proteins are implicated in the progression of atherosclerosis; however, the underlying molecular mechanisms have not yet been fully defined. In this study, we determined how epsins enhance endothelial-to-mesenchymal transition (EndoMT) in atherosclerosis and assessed the efficacy of a therapeutic peptide in a preclinical model of this disease.METHODS:Using single-cell
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Cardiovascular Disease Among Persons Living With HIV: New Insights Into Pathogenesis and Clinical Manifestations in a Global Context Circulation (IF 39.918) Pub Date : 2022-12-28 Mpiko Ntsekhe, Jason V. Baker
Widespread use of contemporary antiretroviral therapy globally has transformed HIV disease into a chronic illness associated with excess risk for disorders of the heart and circulatory system. Current clinical care and research has focused on improving HIV-related cardiovascular disease outcomes, survival, and quality of life. In high-income countries, emphasis on prevention of atherosclerotic coronary
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The Value of Measuring Lipoprotein(a) in Children. Circulation (IF 39.918) Pub Date : 2022-12-28 Michael Khoury,Shoa L Clarke
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Tackling Adversity and Cardiovascular Health: It is About Time. Circulation (IF 39.918) Pub Date : 2022-12-28 Sarah K Westcott,Tené T Lewis,Michelle A Albert
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The MIDA-Q Mortality Risk Score: A Quantitative Prognostic Tool for the Mitral Valve Prolapse Spectrum Circulation (IF 39.918) Pub Date : 2022-12-27 Benjamin Essayagh, Giovanni Benfari, Clemence Antoine, Francesco Grigioni, Thierry Le Tourneau, Jean-Christian Roussel, Jeroen J. Bax, Victoria Delgado, Nina Ajmone Marsan, Aniek van Wijngaarden, Christophe Tribouilloy, Dan Rusinaru, Aviram Hochstadt, Yan Topilsky, Prabin Thapa, Hector I. Michelena, Maurice Enriquez-Sarano
BACKGROUND:Mitral valve prolapse (MVP) is responsible for a considerable disease burden but is widely heterogeneous. The lack of a comprehensive prognostic instrument covering the entire MVP spectrum, encompassing the quantified consequent degenerative mitral regurgitation (DMR), hinders clinical management and therapeutic trials.METHODS:The new Mitral Regurgitation International Database Quantitative
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Adults With Congenital Heart Disease: Trends in Event-Free Survival Past Middle Age Circulation (IF 39.918) Pub Date : 2022-12-26 Mikael Dellborg, Kok Wai Giang, Peter Eriksson, Hans Liden, Maria Fedchenko, Anders Ahnfelt, Annika Rosengren, Zacharias Mandalenakis
BACKGROUND:The survival of children with congenital heart disease has increased substantially over the past decades, with 97% currently reaching adulthood. The total effect of advanced treatment on future mortality and morbidity in adult survivors with congenital heart disease (CHD) is less well described.METHODS:We used data from the Swedish National Inpatient, Outpatient, and Cause of Death Register
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Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia Circulation (IF 39.918) Pub Date : 2022-12-23 Zihan Ma, Chenfeng Mao, Xiao Chen, Shiyu Yang, Zhihua Qiu, Baoqi Yu, Yiting Jia, Chao Wu, Yiyi Wang, Yuhui Wang, Rui Gu, Fang Yu, Yanhui Yin, Xian Wang, Qingbo Xu, Chuanju Liu, Yuhua Liao, Jingang Zheng, Yi Fu, Wei Kong
BACKGROUND:The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with thrombospondin type 1 motif 7) is a novel locus associated with human coronary atherosclerosis. ADAMTS-7 deletion protects against atherosclerosis and vascular restenosis in rodents.METHODS:We designed 3 potential vaccines consisting of distinct B cell epitopic peptides derived from ADAMTS-7 and conjugated with the carrier
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Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis Circulation (IF 39.918) Pub Date : 2022-12-20 Amanda E. Paluch, Shivangi Bajpai, Marcel Ballin, David R. Bassett, Thomas W. Buford, Mercedes R. Carnethon, Ariel Chernofsky, Erin E. Dooley, Ulf Ekelund, Kelly R. Evenson, Deborah A. Galuska, Barbara J. Jefferis, Lingsong Kong, William E. Kraus, Martin G. Larson, I-Min Lee, Charles E. Matthews, Robert L. Newton Jr, Anna Nordström, Peter Nordström, Priya Palta, Alpa V. Patel, Kelley Pettee Gabriel
BACKGROUND:Taking fewer than the widely promoted “10 000 steps per day” has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose–response relationship between steps per day and CVD can help inform clinical and public health guidelines.METHODS:Eight prospective studies
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Shortness of Breath and Near Syncope During Exertion in a Child: When–Patients–Worry Syndrome Circulation (IF 39.918) Pub Date : 2022-12-19 Brandy Hattendorf, S. Chandra Bose Reddy
A previously healthy 14-year-old male patient reported shortness of breath and near syncope during a basketball game. His initial evaluation by a pulmonologist included an exercise pulmonary function test that was reported as normal. The patient presented for cardiac evaluation for persistent symptoms. On general physical examination, his vital signs and clinical cardiac examination were normal. His
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Effect of Intensive Blood Pressure Control on Troponin and Natriuretic Peptide Levels: Findings From SPRINT Circulation (IF 39.918) Pub Date : 2022-12-19 Jarett D. Berry, Haiying Chen, Vijay Nambi, Walter T. Ambrosius, Simon B. Ascher, Michael G. Shlipak, Joachim H. Ix, Rajesh Gupta, Anthony Killeen, Robert D. Toto, Dalane W. Kitzman, Christie M. Ballantyne, James A. de Lemos
BACKGROUND:Given the important role of cardiac injury and neurohormonal activation in the pathways leading from hypertension to heart failure and strong associations observed between hypertension and its sequelae on hs-cTnT (high-sensitivity cardiac troponin T) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, we hypothesized that intensive systolic blood pressure (SBP) lowering would
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Straight to the Heart: T Cells That Specifically Target Cardiac Tissue. Circulation (IF 39.918) Pub Date : 2022-12-19 Wesley T Abplanalp,Maximilian Merten,Stefanie Dimmeler
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What Is the Future of Factor XI Inhibitors? Circulation (IF 39.918) Pub Date : 2022-12-19 Jeffrey I Weitz,John W Eikelboom
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Risk of Heart Failure in Congenital Heart Disease: A Nationwide Register-based Cohort Study. Circulation (IF 39.918) Pub Date : 2022-12-19 Niklas Bergh,Kristofer Skoglund,Maria Fedchenko,Entela Bollano,Peter Eriksson,Mikael Dellborg,Kok Wai Giang,Zacharias Mandalenakis
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Stages of Valvular Heart Disease Among Older Adults in the Community: The Atherosclerosis Risk in Communities Study Circulation (IF 39.918) Pub Date : 2022-12-16 Khaled Shelbaya, Brian Claggett, Pranav Dorbala, Hicham Skali, Scott D. Solomon, Kunihiro Matsushita, Suma Konety, Thomas H. Mosley, Amil M. Shah
BACKGROUND:Limited data exist on American College of Cardiology/American Heart Association valvular heart disease (VHD) stage prevalence, progression, and association with incident cardiovascular diseases in late life.METHODS:Participants in the ARIC study (Atherosclerosis Risk in Communities), a prospective community-based cohort study, underwent protocol echocardiography at ARIC visits 5 (2011–2013)
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Challenging the Hemodynamic Hypothesis in Heart Failure With Preserved Ejection Fraction: Is Exercise Capacity Limited by Elevated Pulmonary Capillary Wedge Pressure? Circulation (IF 39.918) Pub Date : 2022-12-16 Satyam Sarma, James P. MacNamara, Bryce N. Balmain, Christopher M. Hearo Jr, Denis J. Wakeham, Andrew R. Tomlinson, Linda S. Hynan, Tony G. Babb, Benjamin D. Levine
BACKGROUND:Exercise intolerance is a defining characteristic of heart failure with preserved ejection fraction (HFpEF). A marked rise in pulmonary capillary wedge pressure (PCWP) during exertion is pathognomonic for HFpEF and is thought to be a key cause of exercise intolerance. If true, acutely lowering PCWP should improve exercise capacity. To test this hypothesis, we evaluated peak exercise capacity
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Coronary Artery Lesion Lipid Content and Plaque Burden in Diabetic and Nondiabetic Patients: PROSPECT II Circulation (IF 39.918) Pub Date : 2022-12-16 Christine Gyldenkerne, Michael Maeng, Lars Kjøller-Hansen, Akiko Maehara, Zhipeng Zhou, Ori Ben-Yehuda, Hans Erik Bøtker, Thomas Engstrøm, Mitsuaki Matsumura, Gary S. Mintz, Ole Fröbert, Jonas Persson, Rune Wiseth, Alf I. Larsen, Lisette O. Jensen, Jan E. Nordrehaug, Øyvind Bleie, Elmir Omerovic, Claes Held, Stefan K. James, Ziad A. Ali, Hans C. Rosen, Gregg W. Stone, David Erlinge
BACKGROUND:Patients with diabetes have increased rates of major adverse cardiac events (MACEs). We hypothesized that this is explained by diabetes-associated differences in coronary plaque morphology and lipid content.METHODS:In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), 898 patients with acute myocardial infarction with or without ST-segment elevation
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Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization Circulation (IF 39.918) Pub Date : 2022-12-16 Kevin R. Bersell, Tao Yang, Jonathan D. Mosley, Andrew M. Glazer, Andrew T. Hale, Dmytro O. Kryshtal, Kyungsoo Kim, Jeffrey D. Steimle, Jonathan D. Brown, Joe-Elie Salem, Courtney C. Campbell, Charles C. Hong, Quinn S. Wells, Amanda N. Johnson, Laura Short, Marcia A. Blair, Elijah R. Behr, Evmorfia Petropoulou, Yalda Jamshidi, Mark D. Benson, Michelle J. Keyes, Debby Ngo, Ramachandran S. Vasan, Qiong
BACKGROUND:Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated channel alpha subunit 5) in ≈20% of subjects. We identified a family with 4 individuals diagnosed with BrS harboring the rare G145R missense variant in the cardiac transcription factor TBX5 (T-box transcription factor 5) and no SCN5A
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Randomized Trials Fit for the 21st Century: A Joint Opinion From the European Society of Cardiology, American Heart Association, American College of Cardiology, and the World Heart Federation. Circulation (IF 39.918) Pub Date : 2022-12-16 Louise Bowman,Franz Weidinger,Michelle A Albert,Edward T A Fry,Fausto J Pinto,
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Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression Circulation (IF 39.918) Pub Date : 2022-12-14 Emmanuelle Born, Larissa Lipskaia, Marielle Breau, Amal Houssaini, Delphine Paulette Beaulieu, Elizabeth Marcos, Remi Pierre, Marcio Do Cruzeiro, Marine Lefevre, Genevieve Derumeaux, Dmitry V. Bulavin, Marion Delcroix, Rozenn Quarck, Virinder Reen, Jesus Gil, David Bernard, Jean-Michel Flaman, Serge Adnot, Shariq Abid
BACKGROUND:Senescent cells (SCs) are involved in proliferative disorders, but their role in pulmonary hypertension remains undefined. We investigated SCs in patients with pulmonary arterial hypertension and the role of SCs in animal pulmonary hypertension models.METHODS:We investigated senescence (p16, p21) and DNA damage (γ-H2AX, 53BP1) markers in patients with pulmonary arterial hypertension and
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The Effect of Lymphangiogenesis in Transplant Arteriosclerosis Circulation (IF 39.918) Pub Date : 2022-12-14 Kai Chen, Rong Mou, Pengwei Zhu, Xiaodong Xu, Han Wang, Liujun Jiang, Yanhua Hu, Xiaosheng Hu, Liang Ma, Qingzhong Xiao, Qingbo Xu
BACKGROUND:Transplant arteriosclerosis is a major complication in long-term survivors of heart transplantation. Increased lymph flow from donor heart to host lymph nodes has been reported to play a role in transplant arteriosclerosis, but how lymphangiogenesis affects this process is unknown.METHODS:Vascular allografts were transplanted among various combinations of mice, including wild-type, Lyve
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GLP-1 Receptor Agonists for the Reduction of Atherosclerotic Cardiovascular Risk in Patients With Type 2 Diabetes Circulation (IF 39.918) Pub Date : 2022-12-12 Nikolaus Marx, Mansoor Husain, Michael Lehrke, Subodh Verma, Naveed Sattar
Patients with type 2 diabetes are at high risk for development of cardiovascular disease, including myocardial infarction, stroke, heart failure, and cardiovascular death. Multiple large cardiovascular outcome trials with novel glucose-lowering agents, namely SGLT2i (SGLT2 inhibitors) and GLP-1 RA (GLP-1 receptor agonists), have demonstrated robust and significant reductions of major adverse cardiovascular
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Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association Circulation (IF 39.918) Pub Date : 2022-12-12 Abdulla A. Damluji, Daniel E. Forman, Tracy Y. Wang, Joanna Chikwe, Vijay Kunadian, Michael W. Rich, Bessie A. Young, Robert L. Page II, Holli A. DeVon, Karen P. Alexander, on behalf of the American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology, Council on Lifestyle and Cardiometabolic Health, and Council on Cardiovascular Radiology and
Diagnostic and therapeutic advances during the past decades have substantially improved health outcomes for patients with acute coronary syndrome. Both age-related physiological changes and accumulated cardiovascular risk factors increase the susceptibility to acute coronary syndrome over a lifetime. Compared with younger patients, outcomes for acute coronary syndrome in the large and growing demographic
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Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction Circulation (IF 39.918) Pub Date : 2022-12-12 Hidenori Tani, Taketaro Sadahiro, Yu Yamada, Mari Isomi, Hiroyuki Yamakawa, Ryo Fujita, Yuto Abe, Tatsuya Akiyama, Koji Nakano, Yuta Kuze, Masahide Seki, Yutaka Suzuki, Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Keiichi Fukuda, Masaki Ieda
BACKGROUND:Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form fibrosis, leading to cardiac dysfunction and heart failure. Therapies that can regenerate the myocardium and reverse fibrosis in chronic MI are lacking. The overexpression of cardiac transcription factors, including M
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Response by Sedej and Abdellatif to Letter Regarding Article, "Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity". Circulation (IF 39.918) Pub Date : 2022-12-12 Simon Sedej,Mahmoud Abdellatif
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Coronary Vasospasm With Pulse Field Ablation: Primum Non Nocere. Circulation (IF 39.918) Pub Date : 2022-12-12 N A Mark Estes,Sandeep Jain,Samir Saba
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Kidney Hemodynamic Effects of Angiotensin Receptor Blockade, Sodium-Glucose Cotransporter-2 Inhibition Alone, and Their Combination: A Crossover Randomized Trial in People With Type 2 Diabetes. Circulation (IF 39.918) Pub Date : 2022-12-12 Rosalie A Scholtes,Anne C Hesp,Charlotte M Mosterd,Frank Geurts,Ewout J Hoorn,Daan J Touw,Merle M Krebber,Jaap A Joles,Hiddo J L Heerspink,Daniël H van Raalte
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Letter by Xie and Hou Regarding Article, "Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity". Circulation (IF 39.918) Pub Date : 2022-12-12 Meiying Xie,Lianjie Hou
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Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mortality: Results From 27 Countries Circulation (IF 39.918) Pub Date : 2022-12-12 Barrak Alahmad, Haitham Khraishah, Dominic Royé, Ana Maria Vicedo-Cabrera, Yuming Guo, Stefania I. Papatheodorou, Souzana Achilleos, Fiorella Acquaotta, Ben Armstrong, Michelle L. Bell, Shih-Chun Pan, Micheline de Sousa Zanotti Stagliorio Coelho, Valentina Colistro, Tran Ngoc Dang, Do Van Dung, Francesca K. De’ Donato, Alireza Entezari, Yue-Liang Leon Guo, Masahiro Hashizume, Yasushi Honda, Ene Indermitte
Background:Cardiovascular disease is the leading cause of death worldwide. Existing studies on the association between temperatures and cardiovascular deaths have been limited in geographic zones and have generally considered associations with total cardiovascular deaths rather than cause-specific cardiovascular deaths.Methods:We used unified data collection protocols within the Multi-Country Multi-City
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Novel Cardiokine GDF3 Predicts Adverse Fibrotic Remodelin After Myocardial Infarction Circulation (IF 39.918) Pub Date : 2022-12-09 Nihar Masurkar, Marion Bouvet, Damien Logeart, Charlène Jouve, Fatou Dramé, Olivier Claude, Maguelonne Roux, Clément Delacroix, Damien Bergerot, Jean-Jacques Mercadier, Marc Sirol, Barnabas Gellen, Marine Livrozet, Antoine Fayol, Estelle Robidel, David-Alexandre Trégouët, Giovanna Marazzi, David Sassoon, Mariana Valente, Jean-Sébastien Hulot
BACKGROUND:Myocardial infarction (MI) induces a repair response that ultimately generates a stable fibrotic scar. Although the scar prevents cardiac rupture, an excessive profibrotic response impairs optimal recovery by promoting the development of noncontractile fibrotic areas. The mechanisms that lead to cardiac fibrosis are diverse and incompletely characterized. We explored whether the expansion
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Placental Inflammation Leads to Abnormal Embryonic Heart Development Circulation (IF 39.918) Pub Date : 2022-12-09 Eleanor J. Ward, Serena Bert, Silvia Fanti, Kerri M. Malone, Robert T. Maughan, Christina Gkantsinikoudi, Fabrice Prin, Lia Karina Volpato, Anna Paula Piovezan, Gerard J. Graham, Neil P. Dufton, Mauro Perretti, Federica M. Marelli-Berg, Suchita Nadkarni
BACKGROUND:Placental heart development and embryonic heart development occur in parallel, and these organs have been proposed to exert reciprocal regulation during gestation. Poor placentation has been associated with congenital heart disease, an important cause of infant mortality. However, the mechanisms by which altered placental development can lead to congenital heart disease remain unresolved
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Complementary and Alternative Medicines in the Management of Heart Failure: A Scientific Statement From the American Heart Association Circulation (IF 39.918) Pub Date : 2022-12-08 Sheryl L. Chow, Biykem Bozkurt, William L. Baker, Barry E. Bleske, Khadijah Breathett, Gregg C. Fonarow, Barry Greenberg, Prateeti Khazanie, Jacinthe Leclerc, Alanna A. Morris, Nosheen Reza, Clyde W. Yancy, on behalf of the American Heart Association Clinical Pharmacology Committee and Heart Failure and Transplantation Committee of the Council on Clinical Cardiology, Council on Epidemiology and Prevention
Complementary and alternative medicines (CAM) are commonly used across the world by diverse populations and ethnicities but remain largely unregulated. Although many CAM agents are purported to be efficacious and safe by the public, clinical evidence supporting the use of CAM in heart failure remains limited and controversial. Furthermore, health care professionals rarely inquire or document use of
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Correction to: A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction Circulation (IF 39.918) Pub Date : 2022-12-05
In the article by Rao et al, “A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction,” which published online on August 27, 2022, and appears in the October 18, 2022, issue of the journal (Circulation. 2022;146:1196–1206. doi: 10
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Yield of Cardiac Magnetic Resonance Imaging in a Preparticipation Cohort of Young Asian Males With T Wave Inversion. Circulation (IF 39.918) Pub Date : 2022-12-05 Nishanth Thiagarajan,Wilbert H H Ho,Daniel Y Z Lim,Wesley T W Loo,Goy Shen,Vahul Sundar,Huai Yang Lim,Lian Kiat Lim,Terrance S J Chua,Paul C Y Lim,Hak Chiaw Tang,Choong Hou Koh,Tee Joo Yeo,Daniel T T Chong
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Letter by Song et al Regarding Article, "Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis". Circulation (IF 39.918) Pub Date : 2022-12-05 Yuxuan Song,Congcong Ding,Tao Xu
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Response by Zhao et al to Letter Regarding Article, "Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis". Circulation (IF 39.918) Pub Date : 2022-12-05 Bin Zhao,Demetrius Albanes,Jiaqi Huang
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Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and End-Stage Renal Disease: Lessons Learned. Circulation (IF 39.918) Pub Date : 2022-12-05 Alexander P Benz,John W Eikelboom