Catecholaminergic polymorphic ventricular tachycardia (CPVT) and short QT syndrome (SQTS) are inherited arrhythmogenic disorders that can cause sudden death. Numerous genes have been reported to cause these conditions, but evidence supporting these gene–disease relationships varies considerably. To ensure appropriate utilization of genetic information for CPVT and SQTS patients, we applied an evidence-based

British Heart Foundation10.13039/501100000274FS/16/15/32047, TG/19/2/34831, and RG/F/21/110040National Institute for Health Research Oxford Biomedical Research Centre (Oxford, United Kingdom)

Professor Karen Sliwa, Director of the Cape Heart Institute (CHI) at the University of Cape Town (UCT), met with her long-time collaborator, Professor Ana Mocumbi, Vice-President of the Mozambican Institute for Health Education and Research (MIHER) on a recent visit to Mozambique (June 2021).

All correspondence relating to this paper should be sent to: cardiopulse@unicatt.it. Mark Nicholls reports on the controversy surrounding left main revascularization and the hope that the Gulf between cardiologists and cardiac surgeons on the topic can begin to close.

All correspondence relating to this paper should be sent to: cardiopulse@unicatt.it.

The first case of coronavirus disease 2019 (COVID-19) in the USA was reported on 19 January 2020. Over the ensuing months, the virus spread throughout the country and a national emergency was declared on 13 March 2020. There was a significant burden on healthcare services related to the pandemic, with a parallel decline in patients seeking healthcare services for non-coronavirus-related illnesses.

This editorial refers to ‘Cardiovascular magnetic resonance imaging in suspected cardiac tumour: a multicentre outcomes study’, by C. Shenoy et al., doi:10.1093/eurheartj/ehab635.

Cardiovascular magnetic resonance (CMR) imaging is a key diagnostic tool for the evaluation of patients with suspected cardiac tumours. Patient management is guided by the CMR diagnosis, including no further testing if a mass is excluded or if only a pseudomass is found. However, there are no outcomes studies validating this approach.

This editorial refers to ‘Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score’, by J. Hwang et al., doi:10.1093/eurheartj/ehab592 and ‘Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia’, by S. Holm et al., doi:10.1093/eurheartj/ehab506.

This commentary refers to ‘Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis’, by E.P. Navarese et al., doi:10.1093/eurheartj/ehab246; ‘When a meta-analysis equals a single large-scale trial with meaningful follow-up’, by E.P. Navarese et al., doi:10.1093/eurheartj/ehab460; and the discussion

Abstract AimsThe clinical manifestation and outcomes of thrombosis with thrombocytopenia syndrome (TTS) after adenoviral COVID-19 vaccine administration are largely unknown due to the rare nature of the disease. We aimed to analyse the clinical presentation, treatment modalities, outcomes, and prognostic factors of adenoviral TTS, as well as identify predictors for mortality. Methods and ResultsPubMed

This commentary refers to ‘Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis’, by E.P. Navarese et al., doi:10.1093/eurheartj/ehab246; ‘In the pool: dilution or drowning?’, by V. Dayan et al., doi:10.1093/eurheartj/ehab443; ‘When a meta-analysis equals a single large-scale trial with meaningful

In 2008, a 60-year-old man with an anterior ST-segment elevation myocardial infarction and cardiogenic shock underwent coronary angiography: a thrombotic occlusion in the mid-left anterior descending coronary artery (LAD), distal to a coronary aneurysm, was successfully treated with drug-eluting stent (DES) (Supplementary material online, Videos SA1, SA2, SA3, and SA4Supplementary material online,

This editorial refers to ‘Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region’, by P.J. Schwartz et al., doi:10.1093/eurheartj/ehab582.

This editorial refers to ‘Clinical features and survivial in pulmonary Takayasu’s arteritis-associated pulmonary hypertension: a national registry study’, by X. Jiang et al., doi:10.1093/eurheartj/ehab599.

We sought to determine if myocardial energetics could distinguish obesity cardiomyopathy as a distinct entity from dilated cardiomyopathy.

We assessed the impact of the proprotein convertase subtilisin–kexin type 9 (PCSK9) inhibitor evolocumab on acute arterial events across all vascular territories, including coronary, cerebrovascular, and peripheral vascular beds, in patients with established atherosclerotic cardiovascular disease (ASCVD).

AbstractAtrial septal defects (ASDs) represent the most common congenital heart defect diagnosed in adulthood. Although considered a simple defect, challenges in optimal diagnostic and treatment options still exist due to great heterogeneity in terms of anatomy and time-related complications primarily arrhythmias, thromboembolism, right heart failure and, in a subset of patients, pulmonary arterial

Coronary artery disease (CAD) is one of the major global health care and economic burdens. Since percutaneous coronary intervention (PCI) began with balloon angioplasty in 1977, it has more recently been considered that PCI with drug-eluting stents (DES) implantation is the most commonly employed treatment option for patients with CAD.1 As time has progressed, there have been exciting technological

Artificial intelligence (AI) has given the electrocardiogram (ECG) and clinicians reading them super-human diagnostic abilities. Trained without hard-coded rules by finding often subclinical patterns in huge datasets, AI transforms the ECG, a ubiquitous, non-invasive cardiac test that is integrated into practice workflows, into a screening tool and predictor of cardiac and non-cardiac diseases, often

Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. Macrophages play an important role in the development of AAD. As succinate triggers inflammatory changes in macrophages, we investigated the significance of succinate in the pathogenesis of AAD and its clinical relevance.

This editorial refers to ‘Novel biomarker-driven prognostic models to predict morbidity and mortality in chronic heart failure: the EMPEROR-Reduced trial’, by S.J. Pocock et al., doi:10.1093/eurheartj/ehab579.

Abstract Aims Ciraparantag is a reversal agent for anticoagulants including direct oral anticoagulants. The aim was to evaluate the efficacy and safety of ciraparantag to reverse anticoagulation induced by apixaban or rivaroxaban in healthy elderly adults. Methods and results Two randomized, placebo-controlled, dose-ranging trials conducted in healthy subjects aged 50–75 years. Subjects received apixaban

The results of ‘Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk’ have been presented at the 2021 European Society of Cardiology Congress and simultaneously published in the N Engl J Med. doi:10.1056/NEJMoa2108749.

Coronary microvascular disease (CMD), characterized by impaired coronary flow reserve (CFR), is a common finding in patients with stable angina. Impaired CFR, in the absence of obstructive coronary artery disease, is also present in up to 75% of patients with heart failure with preserved ejection fraction (HFpEF). Heart failure with preserved ejection fraction is a heterogeneous syndrome comprising

AIMS  Platelets participate in atherogenesis with mechanisms not yet fully clarified. Vascular wall MMP-2 is involved in the arterial remodelling accompanying atherosclerosis. Platelets contain and release MMP-2 but no informations are available on its role in atherosclerotic lesion formation. METHODS AND RESULTS  We generated double knockout mice lacking the LDL receptor and MMP-2 only in circulating

AIMS In healthy volunteers, the kidney deploys compensatory post-diuretic sodium reabsorption (CPDSR) following loop diuretic-induced natriuresis, minimizing sodium excretion and producing a neutral sodium balance. CPDSR is extrapolated to non-euvolemic populations as a diuretic resistance mechanism; however, its importance in acute decompensated heart failure (ADHF) is unknown. METHODS AND RESULTS

AIMS  The risk and incidence of cardiovascular (CV) immune-related adverse events (irAEs) associated with immune checkpoint inhibitors (ICIs) in cancer patients remain unknown. METHODS AND RESULTS We systematically reviewed all randomized clinical trials (RCTs) including at least one ICI-containing arm and available CV adverse event (CVAE) data in cancer patients in the ClinicalTrials.gov registry

Anti-interleukin (IL)-1 agents have been developed for the treatment of autoinflammatory and rheumatic conditions, where overproduction of IL-1 is an important pathophysiologic process. IL-1α and IL-1β are the most studied members of the IL-1 family of cytokines and have the strongest proinflammatory effects. A naturally occurring antagonist (IL-1Ra) mitigates their proinflammatory effects. Overproduction

This editorial refers to ‘Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data’, by M. Gaudino et al., doi:10.1093/eurheartj/ehab504.

Eur Heart J 2021;42:373–498; doi:10.1093/eurheartj/ehaa612

Sandor Batkai, Celina Genschel, Janika Viereck, Steffen Rump, Christian Bär, Tobias Borchert, Denise Traxler 4, Martin Riesenhuber, Andreas Spannbauer, Dominika Lukovic, Katrin Zlabinger, Ena Hasimbegovic, Johannes Winkler, Rita Garamvölgyi, Sonja Neitzel, Mariann Gyöngyösi, and Thomas Thum Eur Heart J 2021; doi:10.1093/eurheartj/ehaa791.

Key Points This industry-promoted, phase-2, randomized, parallel-group trial compared the efficacy and safety of abelacimab, a fully human monoclonal antibody against factor XI (FXI), with enoxaparin in 412 patients undergoing elective, unilateral total knee arthroplasty (TKA). Patients (mean age, 67 years; 81% female) were randomly assigned in a 1:1:1:1 ratio to receive one of three regimens of abelacimab

This editorial refers to ‘The effect of intravenous ferric carboxymaltose on cardiac reverse remodelling following cardiac resynchronization therapy—the IRON-CRT trial’, by P. Martens et al., doi:10.1093/eurheartj/ehab411.

A 42-year-old male was admitted due to exacerbated heart failure symptoms. One month before, he was diagnosed as severe pneumonia and myocarditis with suspicious cytomegalovirus infection at a local hospital. The 12-lead electrocardiogram displayed sinus tachycardia and low voltage. The echocardiogram revealed enlarged right ventricle (RV), normal-sized left ventricle (LV) with reduced ejection fraction

Intracoronary physiology testing has emerged as a valuable diagnostic approach in the management of patients with chronic coronary syndrome, circumventing limitations like inferring coronary function from anatomical assessment and low spatial resolution associated with angiography or non-invasive tests. The value of hyperaemic translesional pressure ratios to estimate the functional relevance of coronary

AIMS The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial prespecified an analysis to determine whether accounting for recurrent cardiovascular events in addition to first events modified understanding of the treatment effects. METHODS AND RESULTS Patients with stable coronary artery disease (CAD) and moderate or severe ischaemia on stress

AIMS We explored whether a missed cohort of patients in the community with heart failure (HF) and left ventricular systolic dysfunction (LVSD) could be identified and receive treatment optimization through a primary care heart failure (PCHF) service. METHODS AND RESULTS PCHF is a partnership between Inspira Health, National Health Service Cardiologists and Medtronic. The PCHF service uses retrospective

AIMS Traditional atherosclerotic cardiovascular disease (ASCVD) risk factors fail to address the full spectrum of the complex interplay of atherosclerotic and atherothrombotic factors integral to ASCVD events. This study sought to examine the association between atherothrombotic biomarkers and ASCVD events. METHODS AND RESULTS The association between atherothrombotic biomarkers and 877 ASCVD events

AIMS  With the high prevalence of gout and associated cardiovascular (CV) diseases, information on the comparative CV safety of individual urate-lowering drugs becomes increasingly important. However, few studies examined the CV risk of uricosuric agents. We compared CV risk among patients with gout who initiated allopurinol vs. benzbromarone. METHODS AND RESULTS  Using the Korean National Health Insurance

AIMS  This study aimed to assess the clinical characteristics and long-term survival outcome in patients with Takayasu's arteritis-associated pulmonary hypertension (TA-PH). METHODS AND RESULTS We conducted a nationally representative cohort study of TA-PH using data from the National Rare Diseases Registry System of China. Patients with pulmonary artery involvement who fulfilled the diagnostic criteria