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Noninvasive Fibrosis Screening in Fatty Liver Disease Among Vulnerable Populations: Impact of Diabetes and Obesity on FIB-4 Score Accuracy Diabetes Care (IF 17.152) Pub Date : 2022-08-10 Rebecca G. Kim, Jasmine Deng, Jewel N. Reaso, James P. Grenert, Mandana Khalili
OBJECTIVE Fatty liver disease (FLD) is prevalent in diabetes, and both disproportionately affect vulnerable populations. The FIB-4 index is recommended to screen for advanced liver fibrosis. Limited data have suggested that diabetes may impact FIB-4. RESEARCH DESIGN AND METHODS We evaluated FIB-4 accuracy for advanced fibrosis compared with liver biopsy in the presence of diabetes and obesity. RESULTS
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Erratum. Patients With Type 2 Diabetes Have an Increased Demand for Pacemaker Treatment: A Comparison With Age- and Sex-Matched Control Subjects From the General Population. Diabetes Care 2020;44:2853–2858 Diabetes Care (IF 17.152) Pub Date : 2022-08-10 Elina Rautio, Fredrik Gadler, Soffia Gudbjörnsdottir, Stefan Franzén, Lars Rydén, Ann-Marie Svensson, Linda G. Mellbin
In the above-referenced article, it was stated in the Research Design and Methods subsection “Statistical Analysis” and in the Results subsection “Demand for PM Treatment” that pacemaker implantations during the time of observation were expressed as number of events per 10,000 person-years; however, the correct number is events per 100,000 person-years. The authors apologize for the error. The online
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Use of the Steno T1 Risk Engine Identifies Preclinical Atherosclerosis Better Than Use of ESC/EASD-2019 in Adult Subjects With Type 1 Diabetes at High Risk Diabetes Care (IF 17.152) Pub Date : 2022-08-09 Tonet Serés-Noriega, Marga Giménez, Verónica Perea, Laura Boswell, Clara Viñals, Jesús Blanco, Irene Vinagre, Adriana Pané, Enric Esmatjes, Ignacio Conget, Antonio J. Amor
OBJECTIVE To evaluate the concordance between the 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD (ESC/EASD-2019) and the Steno T1 Risk Engine (Steno-Risk) cardiovascular risk scales for individuals with type 1 diabetes (T1D) without cardiovascular disease (CVD) and to analyze the relationships of their use with identification of preclinical
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Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes Diabetes Care (IF 17.152) Pub Date : 2022-08-09 Fu-Rong Li, Daniel Nyarko Hukportie, Jing Yang, Huan-Huan Yang, Guo-Chong Chen, Xian-Bo Wu
OBJECTIVE To examine the association between microvascular disease (MVD) and risk of heart failure (HF) among individuals with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS We included 1,713 and 28,624 participants with T1DM and T2DM, respectively, from the UK Biobank who were free of HF during enrollment. MVD burden reflected by the presence of retinopathy
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The Impact of the COVID-19 Pandemic on Ethnic Minority Groups With Diabetes Diabetes Care (IF 17.152) Pub Date : 2022-08-09 Kamlesh Khunti, Eva L. Feldman, Neda Laiteerapong, William Parker, Ash Routen, Monica Peek
Major ethnic disparities in diabetes care, especially for intermediate outcomes and diabetes complications, were evident prior to the coronavirus disease 2019 (COVID-19) pandemic. Diabetes is a risk factor for severe COVID-19, and the combination of these ethnic disparities in diabetes care and outcomes may have contributed to the inequity in COVID-19 outcomes for people with diabetes. Overall, ethnic
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COVID-19 Exacerbates Insulin Resistance During Diabetic Ketoacidosis in Pediatric Patients With Type 1 Diabetes Diabetes Care (IF 17.152) Pub Date : 2022-08-09 Elizabeth S. Keiner, James C. Slaughter, Karishma A. Datye, Alan D. Cherrington, Daniel J. Moore, Justin M. Gregory
OBJECTIVE Although mortality from coronavirus disease 2019 (COVID-19) among youth with type 1 diabetes is rare, severe acute respiratory syndrome coronavirus 2 is associated with increased pediatric hospitalizations for diabetic ketoacidosis (DKA). To clarify whether the relationship between COVID-19 and DKA is coincidental or causal, we compared tissue glucose disposal (TGD) during standardized treatment
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Early-Phase Changes in Serum Free Fatty Acid Levels After Glucose Intake Are Associated With Type 2 Diabetes Incidence: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases Diabetes Care (IF 17.152) Pub Date : 2022-08-09 Nobuo Sasaki, Ryo Maeda, Ryoji Ozono, Kenichi Yoshimura, Yukiko Nakano, Yukihito Higashi
OBJECTIVE Experimental studies suggest that excess serum free fatty acid (FFA) levels result in impaired glucose metabolism. This study investigated the relationship between changes in serum FFA levels after glucose intake and type 2 diabetes risk. RESEARCH DESIGN AND METHODS This observational study included 6,800 individuals without diabetes who underwent a 75-g oral glucose tolerance test. Serum
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Evolution of Clinical Complexity, Treatment Burden, Health Care Use, and Diabetes-Related Outcomes Among Commercial and Medicare Advantage Plan Beneficiaries With Diabetes in the U.S., 2006–2018 Diabetes Care (IF 17.152) Pub Date : 2022-08-04 Tyler J. Benning, Herbert C. Heien, Rozalina G. McCoy
OBJECTIVE To characterize trends in clinical complexity, treatment burden, health care use, and diabetes-related outcomes among adults with diabetes. RESEARCH DESIGN AND METHODS We used a nationwide claims database to identify enrollees in commercial and Medicare Advantage plans who met claims criteria for diabetes between 1 January 2006 and 31 March 2019 and to quantify annual trends in clinical complexity
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Health Beliefs Associated With Metformin Use Among Insured Adults With Prediabetes Diabetes Care (IF 17.152) Pub Date : 2022-08-04 Laura N. McEwen, Thomas E. Hurst, Kevin L. Joiner, William H. Herman
OBJECTIVE To use the framework of the Health Belief Model (HBM) to explore factors associated with metformin use among adults with prediabetes. RESEARCH DESIGN AND METHODS We analyzed survey data from 200 metformin users and 1,277 nonmetformin users with prediabetes identified from a large, insured workforce. All subjects were offered the National Diabetes Prevention Program (DPP) at no out-of-pocket
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The Association of Measures of Cardiovascular Autonomic Function, Heart Rate, and Orthostatic Hypotension With Incident Glucose Disorders: The Cardiovascular Health Study Diabetes Care (IF 17.152) Pub Date : 2022-08-02 Joshua I. Barzilay, William Tressel, Mary L. Biggs, Phyllis K. Stein, Jorge R. Kizer, Sanyog G. Shitole, Yakubu Bene-Alhasan, Kenneth J. Mukamal
OBJECTIVE The autonomic nervous system (ANS) innervates pancreatic endocrine cells, muscle, and liver, all of which participate in glucose metabolism. We tested whether measures of cardiovascular ANS function are independently associated with incident diabetes and annual change in fasting glucose (FG) levels as well as with insulin secretion and insulin sensitivity in older adults without diabetes
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Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study Diabetes Care (IF 17.152) Pub Date : 2022-08-01 Shengxin Liu, Marica Leone, Jonas F. Ludvigsson, Paul Lichtenstein, Brian D’Onofrio, Ann-Marie Svensson, Soffia Gudbjörnsdottir, Sarah E. Bergen, Henrik Larsson, Ralf Kuja-Halkola, Agnieszka Butwicka
OBJECTIVE To estimate the association and familial coaggregation of childhood-onset type 1 diabetes with depression, anxiety, and stress-related disorders. RESEARCH DESIGN AND METHODS This was a population-based cohort study with use of data from Swedish nationwide registers. A total of ∼3.5 million individuals born in Sweden 1973–2007 were linked to their biological parents, full siblings and half-siblings
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Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies Diabetes Care (IF 17.152) Pub Date : 2022-07-28 Jennifer J. Lee, Tauseef A. Khan, Nema McGlynn, Vasanti S. Malik, James O. Hill, Lawrence A. Leiter, Per Bendix Jeppesen, Dario Rahelić, Hana Kahleová, Jordi Salas-Salvadó, Cyril W.C. Kendall, John L. Sievenpiper
BACKGROUND Adverse associations of low- and no-calorie sweetened beverages (LNCSB) with cardiometabolic outcomes in observational studies may be explained by reverse causality and residual confounding. PURPOSE To address these limitations we used change analyses of repeated measures of intake and substitution analyses to synthesize the association of LNCSB with cardiometabolic outcomes. DATA SOURCES
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Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial Diabetes Care (IF 17.152) Pub Date : 2022-07-27 Yumie Takeshita, Masao Honda, Kenichi Harada, Yuki Kita, Noboru Takata, Hiromasa Tsujiguchi, Takeo Tanaka, Hisanori Goto, Yujiro Nakano, Noriho Iida, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Hiroyuki Nakamura, Shuichi Kaneko, Toshinari Takamura
OBJECTIVE Nonalcoholic fatty liver disease (NAFLD) is a liver phenotype of type 2 diabetes and obesity. Currently, the efficacy of sodium–glucose cotransporter 2 (SGLT2) inhibitors and sulfonylureas in liver pathology and hepatic gene expression profiles for type 2 diabetes with NAFLD are unknown. RESEARCH DESIGN AND METHODS We conducted a 48 week, randomized, open-label, parallel-group trial involving
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Perioperative Fully Closed-Loop Insulin Delivery in Patients Undergoing Elective Surgery: An Open-Label, Randomized Controlled Trial Diabetes Care (IF 17.152) Pub Date : 2022-07-26 David Herzig, Simon Suhner, Jonathan Roos, Daniel Schürch, Luca Cecchini, Christos T. Nakas, Salome Weiss, Alexander Kadner, Gregor J. Kocher, Dominik P. Guensch, Malgorzata E. Wilinska, Andreas Raabe, Klaus A. Siebenrock, Guido Beldi, Beat Gloor, Roman Hovorka, Andreas P. Vogt, Lia Bally
OBJECTIVE Perioperative management of glucose levels remains challenging. We aimed to assess whether fully closed-loop subcutaneous insulin delivery would improve glycemic control compared with standard insulin therapy in insulin-requiring patients undergoing elective surgery. RESEARCH DESIGN AND METHODS We performed a single-center, open-label, randomized controlled trial. Patients with diabetes (other
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Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial Diabetes Care (IF 17.152) Pub Date : 2022-07-26 Alessandra Celli, Yoann Barnouin, Bryan Jiang, Dean Blevins, Georgia Colleluori, Sanjay Mediwala, Reina Armamento-Villareal, Clifford Qualls, Dennis T. Villareal
OBJECTIVE Lifestyle intervention is recommended as first-line treatment of diabetes at all ages; however, little is known about the efficacy of lifestyle intervention in older adults with diabetes. We aimed to determine whether lifestyle intervention would improve glycemic control and age-relevant outcomes in older adults with diabetes and comorbidities. RESEARCH DESIGN AND METHODS A total of 100 older
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Comparing IADPSG and NICE Diagnostic Criteria for GDM in Predicting Adverse Pregnancy Outcomes Diabetes Care (IF 17.152) Pub Date : 2022-07-26 Yuanying He, Ronald Ching Wan Ma, H. David McIntyre, David A. Sacks, Julia Lowe, Patrick M. Catalano, Wing Hung Tam
OBJECTIVE To compare the performance of diagnostic criteria for gestational diabetes mellitus (GDM) proposed by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) with those endorsed by the National Institute for Health and Care Excellence (NICE) in predicting adverse pregnancy outcomes. RESEARCH DESIGN AND METHODS We performed a secondary data analysis of the Hyperglycemia
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Relation of Incident Type 1 Diabetes to Recent COVID-19 Infection: Cohort Study Using e-Health Record Linkage in Scotland Diabetes Care (IF 17.152) Pub Date : 2022-07-26 Paul M. McKeigue, Stuart McGurnaghan, Luke Blackbourn, Louise E. Bath, David A. McAllister, Thomas M. Caparrotta, Sarah H. Wild, Simon N. Wood, Diane Stockton, Helen M. Colhoun
OBJECTIVE Studies using claims databases reported that SARS-CoV-2 infection >30 days earlier was associated with an increase in the incidence of type 1 diabetes. Using exact dates of diabetes diagnosis from the national register in Scotland linked to virology laboratory data, we sought to replicate this finding. RESEARCH DESIGN AND METHODS A cohort of 1,849,411 individuals aged <35 years without diabetes
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Consistent Effects of Hypoglycemia on Cognitive Function in People With or Without Diabetes Diabetes Care (IF 17.152) Pub Date : 2022-07-25 Clementine E.M. Verhulst, Therese W. Fabricius, Giesje Nefs, Roy P.C. Kessels, Frans Pouwer, Steven Teerenstra, Cees J. Tack, Melanie M. Broadley, Peter L. Kristensen, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
OBJECTIVE Hypoglycemia poses an immediate threat for cognitive function. Due to its association with acute cognitive impairment, the International Hypoglycemia Study Group (IHSG) defines a blood glucose level <3.0 mmol/L as “level 2 hypoglycemia.” In the current study we investigated whether having diabetes, type of diabetes, or hypoglycemia awareness moderates this association. RESEARCH DESIGN AND
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Twenty-Year Temporal Trends in Risk of Ischemic Stroke in Incident Type 2 Diabetes: A Danish Population-Based Cohort Study Diabetes Care (IF 17.152) Pub Date : 2022-07-25 Christine Gyldenkerne, Johnny Kahlert, Kevin K.W. Olesen, Pernille G. Thrane, Henrik T. Sørensen, Reimar W. Thomsen, Michael Maeng
OBJECTIVE We examined temporal trends in risk of first-time ischemic stroke in patients with incident type 2 diabetes mellitus (T2DM) and no prior atherosclerotic cardiovascular disease (ASCVD). RESEARCH DESIGN AND METHODS Using nationwide health registries, we identified all patients with incident T2DM without a prior hospital diagnosis of ASCVD from 1996 to 2015 in Denmark. Patients were assigned
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Incretin-Based Drugs and the Risk of Acute Liver Injury Among Patients With Type 2 Diabetes Diabetes Care (IF 17.152) Pub Date : 2022-07-22 Richeek Pradhan, Hui Yin, Oriana H.Y. Yu, Laurent Azoulay
OBJECTIVE To determine whether the use of dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 receptor agonists (GLP-1 RAs), separately, is associated with an increased risk of acute liver injury compared with the use of sodium–glucose cotransporter 2 (SGLT-2) inhibitors. RESEARCH DESIGN AND METHODS We used the U.K. Clinical Practice Research Datalink linked with the Hospital Episode
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An Isoenergetic Multifactorial Diet Reduces Pancreatic Fat and Increases Postprandial Insulin Response in Patients With Type 2 Diabetes: A Randomized Controlled Trial Diabetes Care (IF 17.152) Pub Date : 2022-07-21 Giuseppe Della Pepa, Valentina Brancato, Giuseppina Costabile, Dominic Salamone, Alessandra Corrado, Marilena Vitale, Carlo Cavaliere, Marcello Mancini, Marco Salvatore, Delia Luongo, Gabriele Riccardi, Angela A. Rivellese, Giovanni Annuzzi, Lutgarda Bozzetto
OBJECTIVE To compare the effect of an isocaloric multifactorial diet with a diet rich in monounsaturated fatty acids (MUFA) and similar macronutrient composition on pancreatic fat (PF) and postprandial insulin response in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS According to a randomized controlled parallel-group design, 39 individuals with T2D, 35–75 years old, in satisfactory blood glucose
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Periconceptional and First Trimester Ultraprocessed Food Intake and Maternal Cardiometabolic Outcomes Diabetes Care (IF 17.152) Pub Date : 2022-07-19 Samrawit F. Yisahak, Stefanie N. Hinkle, Sunni L. Mumford, Jessica L. Gleason, Katherine L. Grantz, Cuilin Zhang, Jagteshwar Grewal
OBJECTIVE Ultraprocessed foods (UPFs) have been linked with obesity and cardiometabolic diseases in the general population but are understudied in pregnancy. We examined associations of UPF intake with gestational weight gain (GWG), glycemic, and blood pressure outcomes in pregnancy. RESEARCH DESIGN AND METHODS Pregnant women (n = 1,948) in a prospective U.S. cohort self-reported the past 3-month diet
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Elevated Retinol Binding Protein 3 Concentrations Are Associated With Decreased Vitreous Inflammatory Cytokines, VEGF, and Progression of Diabetic Retinopathy Diabetes Care (IF 17.152) Pub Date : 2022-07-19 Ward Fickweiler, Hyunseok Park, Kyoungmin Park, Margalit G. Mitzner, Tanvi Chokshi, Tahani Boumenna, John Gautier, Yumi Zaitsu, I-Hsien Wu, Jerry Cavallerano, Lloyd P. Aiello, Jennifer K. Sun, George L. King
OBJECTIVE To correlate inflammatory cytokines and vascular endothelial growth factor (VEGF) in vitreous and plasma with vitreous retinol binding protein 3 (RBP3), diabetic retinopathy (DR) severity, and DR worsening in a population with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS RBP3, VEGF, and inflammatory cytokines were measured in plasma and vitreous samples (n = 205) from subjects
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Changes in Visual Impairment due to Diabetic Retinopathy During 1980–2019 Based on Nationwide Register Data Diabetes Care (IF 17.152) Pub Date : 2022-07-15 Petri K.M. Purola, Matti U.I. Ojamo, Mika Gissler, Hannu M.T. Uusitalo
OBJECTIVE To evaluate changes in the incidence, prevalence, severity, and onset age of visual impairment (VI) due to diabetic retinopathy (DR) and compare these trends in the screening and treatment of diabetes during 40 years based on Finnish national register data. RESEARCH DESIGN AND METHODS We included people with VI with nonproliferative DR (NPDR; n = 2,490, 73% women) or proliferative DR (PDR;
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National Trends in the Achievement of Recommended Strategies for Stroke Prevention in U.S. Adults With Type 2 Diabetes, 2001–2018 Diabetes Care (IF 17.152) Pub Date : 2022-07-14 Shihchen Kuo, Chun-Ting Yang, William H. Herman, Lynda D. Lisabeth, Wen Ye
OBJECTIVE To assess the national prevalence of and trends in achieving current guideline-recommended treatment goals and pharmacotherapies for primary and secondary prevention of stroke among U.S. adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We performed serial cross-sectional analyses in 4,834 adults aged ≥45 years with T2D who participated in the 2001–2018 National Health and Nutrition
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Remnant Cholesterol and Its Visit-to-Visit Variability Predict Cardiovascular Outcomes in Patients With Type 2 Diabetes: Findings From the ACCORD Cohort Diabetes Care (IF 17.152) Pub Date : 2022-07-14 Liyao Fu, Shi Tai, Jiaxing Sun, Ningjie Zhang, Ying Zhou, Zhenhua Xing, Yongjun Wang, Shenghua Zhou
OBJECTIVE Remnant cholesterol (remnant-C) predicts atherosclerotic cardiovascular disease, regardless of LDL-cholesterol (LDL-C) levels. This study assessed the associations between remnant-C and cardiovascular outcomes in type 2 diabetes. RESEARCH DESIGN AND METHODS This post hoc analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial used patient (type 2 diabetes >3 months)
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Population-Level Impact and Cost-effectiveness of Continuous Glucose Monitoring and Intermittently Scanned Continuous Glucose Monitoring Technologies for Adults With Type 1 Diabetes in Canada: A Modeling Study Diabetes Care (IF 17.152) Pub Date : 2022-07-14 Michael A. Rotondi, Octavia Wong, Michael Riddell, Bruce Perkins
OBJECTIVE Maintaining healthy glucose levels is critical for the management of type 1 diabetes (T1D), but the most efficacious and cost-effective approach (capillary self-monitoring of blood glucose [SMBG] or continuous [CGM] or intermittently scanned [isCGM] glucose monitoring) is not clear. We modeled the population-level impact of these three glucose monitoring systems on diabetes-related complications
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Association of Metabolic Syndrome With Incident Dementia: Role of Number and Age at Measurement of Components in a 28-Year Follow-up of the Whitehall II Cohort Study Diabetes Care (IF 17.152) Pub Date : 2022-07-12 Marcos D. Machado-Fragua, Aurore Fayosse, Manasa Shanta Yerramalla, Thomas T. van Sloten, Adam G. Tabak, Mika Kivimaki, Séverine Sabia, Archana Singh-Manoux
OBJECTIVE Previous research suggests an inconsistent association between Metabolic syndrome (MetS) and incident dementia. We examined the role of number of MetS components and age at their assessment for incident dementia. RESEARCH DESIGN AND METHODS MetS components (fasting glucose, triglycerides, waist circumference, blood pressure, and HDL cholesterol) on 7,265, 6,660, and 3,608 participants at
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Undiagnosed Diabetes in U.S. Adults: Prevalence and Trends Diabetes Care (IF 17.152) Pub Date : 2022-07-11 Michael Fang, Dan Wang, Josef Coresh, Elizabeth Selvin
OBJECTIVE Confirmatory testing is recommended for diabetes diagnosis in clinical practice. However, national estimates of undiagnosed diabetes are based on single elevated test measures, potentially resulting in overestimation. Our objective was to update trends in undiagnosed diabetes using definitions consistent with clinical practice. RESEARCH DESIGN AND METHODS We included 30,492 adults (aged ≥20
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Metabolic, Intestinal, and Cardiovascular Effects of Sotagliflozin Compared With Empagliflozin in Patients With Type 2 Diabetes: A Randomized, Double-Blind Study Diabetes Care (IF 17.152) Pub Date : 2022-07-11 Maximilian G. Posch, Niklas Walther, Ele Ferrannini, David R. Powell, Phillip Banks, Suman Wason, Raphael Dahmen
OBJECTIVE Inhibiting sodium–glucose cotransporters (SGLTs) improves glycemic and cardiovascular outcomes in patients with type 2 diabetes (T2D). We investigated the differential impact of selective SGLT2 inhibition and dual inhibition of SGLT1 and SGLT2 on multiple parameters. RESEARCH DESIGN AND METHODS Using a double-blind, parallel-group design, we randomized 40 patients with T2D and hypertension
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Protein Biomarkers and Cardiovascular Outcomes in People With Type 2 Diabetes and Acute Coronary Syndrome: The ELIXA Biomarker Study Diabetes Care (IF 17.152) Pub Date : 2022-07-11 Hertzel C. Gerstein, Sibylle Hess, Brian Claggett, Kenneth Dickstein, Lars Kober, Aldo P. Maggioni, John J.V. McMurray, Jeffrey L. Probstfield, Matthew C. Riddle, Jean-Claude Tardif, Marc A. Pfeffer
OBJECTIVE To use protein biomarkers to identify people with type 2 diabetes at high risk of cardiovascular outcomes and death. RESEARCH DESIGN AND METHODS Biobanked serum from 4,957 ELIXA (Evaluation of Lixisenatide in Acute Coronary Syndrome) trial participants was analyzed. Forward-selection Cox models identified independent protein risk factors for major adverse cardiovascular events (MACE) and
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Optimal Number of Steps per Day to Prevent All-Cause Mortality in People With Prediabetes and Diabetes Diabetes Care (IF 17.152) Pub Date : 2022-07-07 Jesus del Pozo-Cruz, Francisco Alvarez-Barbosa, Daniel Gallardo-Gomez, Borja del Pozo Cruz
OBJECTIVE We aimed to examine the dose-response associations between the number of steps per day and all-cause mortality among adults with prediabetes and diabetes. RESEARCH DESIGN AND METHODS This prospective study used data from 1,194 U.S. adults with prediabetes and 493 with diabetes for whom accelerometer-derived steps per day could be retrieved. Mortality was ascertained through the National Death
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Long-term Survival After Sleeve Gastrectomy Versus Gastric Bypass in a Binational Cohort Study Diabetes Care (IF 17.152) Pub Date : 2022-07-07 Dag Holmberg, Giola Santoni, Joonas H. Kauppila, Sheraz R. Markar, Jesper Lagergren
OBJECTIVE Bariatric surgery prolongs life expectancy in severely obese individuals, but it is uncertain which of the two dominating bariatric procedures, sleeve gastrectomy or gastric bypass, offers the best long-term survival. RESEARCH DESIGN AND METHODS This was a population-based cohort study of primary laparoscopic sleeve gastrectomy compared with gastric bypass for obesity in Sweden and Finland
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The Charcot Foot Reflects a Response to Injury That Is Critically Distorted by Preexisting Nerve Damage: An Imperfect Storm Diabetes Care (IF 17.152) Pub Date : 2022-07-07 William Jeffcoate, Fran Game
It has been recognized since comprehensive descriptions by Jean-Martin Charcot in 1868 and 1883 that development of what is usually known as neuropathic osteoarthropathy (or the Charcot foot) requires the coincidence of neuropathy and inflammation. Despite this, detailed understanding of the causes has remained remarkably limited in the succeeding century and a half. The aim of this descriptive account
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The Use of Point-of-Care Bacterial Autofluorescence Imaging in the Management of Diabetic Foot Ulcers: A Pilot Randomized Controlled Trial Diabetes Care (IF 17.152) Pub Date : 2022-07-07 Sara Rahma, Janet Woods, Sarah Brown, Jane Nixon, David Russell
OBJECTIVE To estimate comparative healing rates and decision-making associated with the use of bacterial autofluorescence imaging in the management of diabetic foot ulcers (DFUs). RESEARCH DESIGN AND METHODS This is a single-center (multidisciplinary outpatient clinic), prospective pilot, randomized controlled trial (RCT) in patients with an active DFU and no suspected clinical infection. Consenting
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Diabetes Care Among Older Adults Enrolled in Medicare Advantage Versus Traditional Medicare Fee-For-Service Plans: The Diabetes Collaborative Registry Diabetes Care (IF 17.152) Pub Date : 2022-07-07 Utibe R. Essien, Yuanyuan Tang, Jose F. Figueroa, Terrence Michael A. Litam, Fengming Tang, Philip G. Jones, Ravi Patel, Rishi K. Wadhera, Nihar R. Desai, Sanjeev N. Mehta, Mikhail N. Kosiborod, Muthiah Vaduganathan
OBJECTIVE Medicare Advantage (MA), Medicare’s managed care program, is quickly expanding, yet little is known about diabetes care quality delivered under MA compared with traditional fee-for-service (FFS) Medicare. RESEARCH DESIGN AND METHODS This was a retrospective cohort study of Medicare beneficiaries ≥65 years old enrolled in the Diabetes Collaborative Registry from 2014 to 2019 with type 2 diabetes
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Coexistent Diabetes Is Associated With the Presence of Adverse Phenotypic Features in Patients With Hypertrophic Cardiomyopathy Diabetes Care (IF 17.152) Pub Date : 2022-07-05 Nicholas Jex, Amrit Chowdhary, Sharmaine Thirunavukarasu, Henry Procter, Anshuman Sengupta, Pavithra Natarajan, Sindhoora Kotha, Ana-Maria Poenar, Peter Swoboda, Hui Xue, Richard M. Cubbon, Peter Kellman, John P. Greenwood, Sven Plein, Stephen Page, Eylem Levelt
OBJECTIVE Type 2 diabetes mellitus (T2DM) is associated with worsened clinical outcomes in hypertrophic cardiomyopathy (HCM) patients. We sought to investigate whether HCM patients with T2DM comorbidity exhibit adverse cardiac alterations in myocardial energetics, function, perfusion, or tissue characteristics. RESEARCH DESIGN AND METHODS A total of 55 participants with concomitant HCM and T2DM (HCM-DM)
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The Cost of Control: Cost-Effectiveness Analysis of Hybrid Closed-Loop Therapy in Youth Diabetes Care (IF 17.152) Pub Date : 2022-07-01 Anthony Pease, Emily Callander, Ella Zomer, Mary B. Abraham, Elizabeth A. Davis, Timothy W. Jones, Danny Liew, Sophia Zoungas
OBJECTIVE Hybrid closed-loop (HCL) therapy is an efficacious management strategy for young people with type 1 diabetes. However, high costs prevent equitable access. We thus sought to evaluate the cost-effectiveness of HCL therapy compared with current care among young people with type 1 diabetes in Australia. RESEARCH DESIGN AND METHODS A patient-level Markov model was constructed to simulate disease
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Clinical Utility of Cardiovascular Risk Scores for Identification of People With Type 2 Diabetes More Likely to Benefit From Either GLP-1 Receptor Agonist or SGLT2 Inhibitor Therapy Diabetes Care (IF 17.152) Pub Date : 2022-07-01 Julian W. Sacre, Dianna J. Magliano, Jonathan E. Shaw
OBJECTIVE Differentiation of risk for major adverse cardiovascular events (MACE) from heart failure hospitalization (HHF) or kidney disease is important when selecting glucose-lowering therapy. We investigated the ability of separate MACE and HHF risk scores to 1) differentiate MACE from HHF risk; and 2) identify individuals more likely to benefit from either glucagon-like peptide-1 receptor agonists
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Household Food Insecurity and Fear of Hypoglycemia in Adolescents and Young Adults With Diabetes and Parents of Youth With Diabetes Diabetes Care (IF 17.152) Pub Date : 2022-06-30 Lauren A. Reid, Siyu Zheng, Jason A. Mendoza, Beth A. Reboussin, Alissa J. Roberts, Katherine A. Sauder, Jean M. Lawrence, Elizabeth Jensen, Leora Henkin, Kate Flory, Lisa M. Knight, Catherine Pihoker, Lawrence M. Dolan, Elaine M. Apperson, Angela D. Liese
OBJECTIVE To evaluate the relation between household food insecurity (HFI) and fear of hypoglycemia among young adults with type 1 and type 2 diabetes and adolescents with type 1 diabetes and their parents. RESEARCH DESIGN AND METHODS We analyzed cross-sectional data of 1,676 young adults with youth-onset diabetes (84% type 1, 16% type 2) and 568 adolescents (<18 years old; mean age 15.1 years) with
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Measures of Insulin Resistance as a Screening Tool for Dysglycemia in Patients With Coronary Artery Disease: A Report From the EUROASPIRE V Population Diabetes Care (IF 17.152) Pub Date : 2022-06-30 Giulia Ferrannini, Dirk De Bacquer, Iris Erlund, Viveca Gyberg, Kornelia Kotseva, Linda Mellbin, Anna Norhammar, Oliver Schnell, Jaakko Tuomilehto, Terhi Vihervaara, David Wood, Lars Rydén
OBJECTIVE The optimal screening strategy for dysglycemia (including type 2 diabetes and impaired glucose tolerance) in patients with coronary artery disease (CAD) is debated. We tested the hypothesis that measures of insulin resistance by HOMA indexes may constitute good screening methods. RESEARCH DESIGN AND METHODS Insulin, C-peptide, glycated hemoglobin A1c, and an oral glucose tolerance test (OGTT)
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Rural-Urban Differences in Diabetes Care and Control in 42 Low- and Middle-Income Countries: A Cross-sectional Study of Nationally Representative Individual-Level Data Diabetes Care (IF 17.152) Pub Date : 2022-06-30 David Flood, Pascal Geldsetzer, Kokou Agoudavi, Krishna K. Aryal, Luisa Campos Caldeira Brant, Garry Brian, Maria Dorobantu, Farshad Farzadfar, Oana Gheorghe-Fronea, Mongal Singh Gurung, David Guwatudde, Corine Houehanou, Jutta M. Adelin Jorgensen, Dimple Kondal, Demetre Labadarios, Maja E. Marcus, Mary Mayige, Mana Moghimi, Bolormaa Norov, Gastón Perman, Sarah Quesnel-Crooks, Mohammad-Mahdi Rashidi
OBJECTIVE Diabetes prevalence is increasing rapidly in rural areas of low- and middle-income countries (LMICs), but there are limited data on the performance of health systems in delivering equitable and effective care to rural populations. We therefore assessed rural-urban differences in diabetes care and control in LMICs. RESEARCH DESIGN AND METHODS We pooled individual-level data from nationally
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Model for Integration of Monogenic Diabetes Diagnosis Into Routine Care: The Personalized Diabetes Medicine Program Diabetes Care (IF 17.152) Pub Date : 2022-06-28 Haichen Zhang, Jeffrey W. Kleinberger, Kristin A. Maloney, Yue Guan, Trevor J. Mathias, Katharine Bisordi, Elizabeth A. Streeten, Kristina Blessing, Mallory N. Snyder, Lee A. Bromberger, Jessica Goehringer, Amy Kimball, Coleen M. Damcott, Casey O. Taylor, Michaela Nicholson, Devon Nwaba, Kathleen Palmer, Danielle Sewell, Nicholas Ambulos, Linda J. B. Jeng, Alan R. Shuldiner, Philip Levin, David J.
OBJECTIVE To implement, disseminate, and evaluate a sustainable method for identifying, diagnosing, and promoting individualized therapy for monogenic diabetes. RESEARCH DESIGN AND METHODS Patients were recruited into the implementation study through a screening questionnaire completed in the waiting room or through the patient portal, physician recognition, or self-referral. Patients suspected of
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Changes in Glucose Metabolism and Glycemic Status With Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants With Prediabetes in the STEP Program Diabetes Care (IF 17.152) Pub Date : 2022-06-20 Leigh Perreault, Melanie Davies, Juan P. Frias, Peter Nørkjaer Laursen, Ildiko Lingvay, Sriram Machineni, Anette Varbo, John P.H. Wilding, Signe Olrik Rytter Wallenstein, Carel W. le Roux
OBJECTIVE This analysis of 3,375 adults with overweight/obesity across the Semaglutide Treatment Effect in People with obesity (STEP) 1, 3, and 4 trials evaluated whether more participants with prediabetes had normoglycemia after 68 weeks’ treatment with once-weekly semaglutide 2.4 mg plus lifestyle intervention versus placebo and assessed changes in glucose metabolism in participants with prediabetes
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Fasting Substrate Concentrations Predict Cardiovascular Outcomes in the CANagliflozin cardioVascular Assessment Study (CANVAS) Diabetes Care (IF 17.152) Pub Date : 2022-06-20 Ele Ferrannini, Simona Baldi, Tiziana Scozzaro, Vasilis Tsimihodimos, Fisseha Tesfaye, Wayne Shaw, Norman Rosenthal, Gemma A. Figtree, Bruce Neal, Kenneth W. Mahaffey, Vlado Perkovic, Michael K. Hansen
OBJECTIVE To examine whether the circulating substrate mix may be related to the incidence of heart failure (HF) and cardiovascular (CV) mortality and how it is altered by canagliflozin treatment. RESEARCH DESIGN AND METHODS We measured fasting glucose, free fatty acids (FFA), glycerol, β-hydroxybutyrate, acetoacetate, lactate, and pyruvate concentrations in 3,581 samples from the CANagliflozin cardioVascular
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Caloric Restriction and Weight Loss Are Primary Factors in the Early Tissue-Specific Metabolic Changes After Bariatric Surgery Diabetes Care (IF 17.152) Pub Date : 2022-06-20 Charles Robb Flynn, Robyn A. Tamboli, Joseph Antoun, Reem M. Sidani, Brandon Williams, Matthew D. Spann, Wayne J. English, E. Brian Welch, Sinju Sundaresan, Naji N. Abumrad
OBJECTIVE To evaluate changes in insulin sensitivity, hormone secretion, and hepatic steatosis immediately after caloric restriction, vertical sleeve gastrectomy (VSG), and Roux-en-Y gastric bypass (RYGB). RESEARCH DESIGN AND METHODS Obese subjects were assessed for 1) insulin sensitivity with hyperinsulinemic-euglycemic clamp with glucose tracer infusion, 2) adipokine concentrations with serum and
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Management and Outcomes of Severe Hypoglycemia Treated by Emergency Medical Services in the U.S. Upper Midwest Diabetes Care (IF 17.152) Pub Date : 2022-06-20 Lucas A. Myers, Kristi M. Swanson, Amy E. Glasgow, Rozalina G. McCoy
OBJECTIVE To examine factors associated with emergency department (ED) transport after hypoglycemia treated by emergency medical services (EMS) and assess the impact of ED transport on severe hypoglycemia recurrence. RESEARCH DESIGN AND METHODS We retrospectively analyzed electronic health records of a multistate advanced life support EMS provider and an integrated healthcare delivery system serving
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Dietary Protein Sources, Mediating Biomarkers, and Incidence of Type 2 Diabetes: Findings From the Women’s Health Initiative and the U.K. Biobank Diabetes Care (IF 17.152) Pub Date : 2022-06-17 Jie Li, Andrea J. Glenn, Qingling Yang, Ding Ding, Lingling Zheng, Wei Bao, Jeannette Beasley, Erin LeBlanc, Kenneth Lo, JoAnn E. Manson, Lawrence Philips, Lesley Tinker, Simin Liu
OBJECTIVE Whether and how dietary protein intake is linked to type 2 diabetes (T2D) remains unclear. The aim of this study was to investigate the associations of protein intake with development of T2D and the potential mediating roles of T2D biomarkers. RESEARCH DESIGN AND METHODS We included 108,681 postmenopausal women without T2D at baseline from the Women’s Health Initiative (WHI) (primary cohort)
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Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation Diabetes Care (IF 17.152) Pub Date : 2022-06-16 Leanne K. Küpers, Sílvia Fernández-Barrés, Giulia Mancano, Laura Johnson, Raffael Ott, Jesus Vioque, Marco Colombo, Kathrin Landgraf, Elmar W. Tobi, Antje Körner, Romy Gaillard, Jeanne H.M. de Vries, Vincent W.V. Jaddoe, Martine Vrijheid, Gemma C. Sharp, Janine F. Felix
OBJECTIVE Suboptimal nutrition in pregnancy is associated with worse offspring cardiometabolic health. DNA methylation may be an underlying mechanism. We meta-analyzed epigenome-wide association studies (EWAS) of maternal dietary glycemic index and load with cord blood DNA methylation. RESEARCH DESIGN AND METHODS We calculated maternal glycemic index and load from food frequency questionnaires and
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Diabetes Distress, Depressive Symptoms, and Anxiety Symptoms in People With Type 2 Diabetes: A Network Analysis Approach to Understanding Comorbidity Diabetes Care (IF 17.152) Pub Date : 2022-06-15 Amy M. McInerney, Nanna Lindekilde, Arie Nouwen, Norbert Schmitz, Sonya S. Deschênes
OBJECTIVE In this study, we aimed to explore interactions between individual items that assess diabetes distress, depressive symptoms, and anxiety symptoms in a cohort of adults with type 2 diabetes using network analysis. RESEARCH DESIGN AND METHODS Participants (N = 1,796) were from the Montreal Evaluation of Diabetes Treatment (EDIT) study from Quebec, Canada. A network of diabetes distress was
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Projected Impact of the Medicare Part D Senior Savings Model (SSM) on Diabetes-Related Health and Economic Outcomes Among Insulin Users Covered by Medicare Diabetes Care (IF 17.152) Pub Date : 2022-06-14 Hui Shao, Dawei Guan, Jingchuan Guo, Tianze Jiao, Yongkang Zhang, Jing Luo, Lizheng Shi, Vivian Fonseca, Joshua D. Brown
OBJECTIVE The Medicare Part D Senior Savings Model (SSM) took effect on 1 January 2021. In this study we estimated the number of beneficiaries who would benefit from SSM and the long-term health and economic consequences of implementing this new policy. RESEARCH DESIGN AND METHODS Data for Medicare beneficiaries with diabetes treated with insulin were extracted from the 2018 Medical Expenditure Panel
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Association Between Insulin Resistance and Cardiovascular Disease Risk Varies According to Glucose Tolerance Status: A Nationwide Prospective Cohort Study Diabetes Care (IF 17.152) Pub Date : 2022-06-14 Tiange Wang, Mian Li, Tianshu Zeng, Ruying Hu, Yu Xu, Min Xu, Zhiyun Zhao, Yuhong Chen, Shuangyuan Wang, Hong Lin, Xuefeng Yu, Gang Chen, Qing Su, Yiming Mu, Lulu Chen, Xulei Tang, Li Yan, Guijun Qin, Qin Wan, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Lixin
OBJECTIVE To investigate whether the association between insulin resistance and cardiovascular disease (CVD) differs by glucose tolerance status. RESEARCH DESIGN AND METHODS We analyzed a nationwide sample of 111,576 adults without CVD at baseline, using data from the China Cardiometabolic Disease and Cancer Cohort Study. Insulin resistance was estimated by sex-specific HOMA of insulin resistance (HOMA-IR)
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Cardiorenal Complications in Young-Onset Type 2 Diabetes Between White and African Americans Diabetes Care (IF 17.152) Pub Date : 2022-06-14 Sanjoy K. Paul, Jonathan E. Shaw, Peter Fenici, Olga Montvida
OBJECTIVE To explore risks and associated mediation effects of developing chronic kidney disease (CKD) and heart failure (HF) in young- and usual-onset type 2 diabetes (T2D) between White Americans (WAs) and African Americans (AAs). RESEARCH DESIGN AND METHODS From U.S. medical records, 1,491,672 WAs and 31,133 AAs were identified and stratified by T2D age of onset (18–39, 40–49, 50–59, 60–70 years)
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Does the Effect of a 3-Year Lifestyle Intervention on Body Weight and Cardiometabolic Health Differ by Prediabetes Metabolic Phenotype? A Post Hoc Analysis of the PREVIEW Study Diabetes Care (IF 17.152) Pub Date : 2022-06-13 Ruixin Zhu, Elli Jalo, Marta P. Silvestre, Sally D. Poppitt, Teodora Handjieva-Darlenska, Svetoslav Handjiev, Maija Huttunen-Lenz, Kelly Mackintosh, Gareth Stratton, Santiago Navas-Carretero, Kirsi H. Pietiläinen, Elizabeth Simpson, Ian A. Macdonald, Roslyn Muirhead, Jennie Brand-Miller, Mikael Fogelholm, Kristine Færch, J. Alfredo Martinez, Margriet S. Westerterp-Plantenga, Tanja C. Adam, Anne Raben
OBJECTIVE To examine whether the effect of a 3-year lifestyle intervention on body weight and cardiometabolic risk factors differs by prediabetes metabolic phenotype. RESEARCH DESIGN AND METHODS This post hoc analysis of the multicenter, randomized trial, PREVention of diabetes through lifestyle interventions and population studies In Europe and around the World (PREVIEW), included 1,510 participants
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Serum Orotidine: A Novel Biomarker of Increased CVD Risk in T2D Discovered Through Metabolomics Studies Diabetes Care (IF 17.152) Pub Date : 2022-06-13 Hetal S. Shah, Lorena Ortega Moreno, Mario Luca Morieri, Yaling Tang, Christine Mendonca, Jenny Marie Jobe, Jonathan B. Thacker, Joanna Mitri, Stefano Monti, Monika A. Niewczas, Subramaniam Pennathur, Alessandro Doria
OBJECTIVE To identify novel biomarkers of cardiovascular disease (CVD) risk in type 2 diabetes (T2D) via a hypothesis-free global metabolomics study, while taking into account renal function, an important confounder often overlooked in previous metabolomics studies of CVD. RESEARCH DESIGN AND METHODS We conducted a global serum metabolomics analysis using the Metabolon platform in a discovery set from
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Continuous Glucose Monitoring Metrics and Birth Weight: Informing Management of Type 1 Diabetes Throughout Pregnancy Diabetes Care (IF 17.152) Pub Date : 2022-06-13 Eleanor M. Scott, Helen R. Murphy, Karl H. Kristensen, Denice S. Feig, Karin Kjölhede, Linda Englund-Ögge, Kerstin E. Berntorp, Graham R. Law
OBJECTIVE To determine gestational weekly changes in continuous glucose monitoring (CGM) metrics and 24-h glucose profiles and their relationship to infant birth weight in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS An analysis of >10.5 million CGM glucose measures from 386 pregnant women with type 1 diabetes from two international multicenter studies was performed. CGM glucose
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The SNAP Cycle and Diabetes Management During a One-Time Change in Disbursement Schedule Diabetes Care (IF 17.152) Pub Date : 2022-06-09 Sabrina K. Young, Alicia Atwood, Lindsay Allen, Nathan Pauly
OBJECTIVE The 2018–2019 federal government partial shutdown resulted in a one-time disruption to the usual disbursement schedule of Supplemental Nutrition Assistance Program (SNAP) benefits nationwide. We assessed the relationship between this disruption and hyperglycemia and hypoglycemia medical encounters among beneficiaries with diabetes. RESEARCH DESIGN AND METHODS To estimate whether the one-time
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Once-Weekly Exenatide in Youth With Type 2 Diabetes Diabetes Care (IF 17.152) Pub Date : 2022-06-09 William V. Tamborlane, Raafat Bishai, David Geller, Naim Shehadeh, Dalia Al-Abdulrazzaq, Evelina Mánica Vazquez, Eva Karoly, Tünde Troja, Orlando Doehring, Debra Carter, John Monyak, C. David Sjöström
OBJECTIVE Approved treatments for type 2 diabetes in pediatric patients include metformin, liraglutide, and insulin. However, approximately one-half of the youth fail metformin monotherapy within 1 year, insulin therapy is associated with challenges, and liraglutide requires daily injections. Consequently, the efficacy and safety of once-weekly injections of exenatide for the treatment of youth with
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Case Fatality of Patients With Type 1 Diabetes After Myocardial Infarction Diabetes Care (IF 17.152) Pub Date : 2022-06-09 Anne M. Kerola, Markus Juonala, Antti Palomäki, Anne Grete Semb, Päivi Rautava, Ville Kytö
OBJECTIVE Type 1 diabetes is a risk factor for myocardial infarction (MI). We aimed to evaluate the case fatality in patients with type 1 diabetes after MI. RESEARCH DESIGN AND METHODS Consecutive patients experiencing MI with type 1 diabetes (n = 1,935; 41% female; mean age 62.5 years) and without diabetes (n = 74,671) admitted to 20 hospitals in Finland from 2005 to 2018 were studied using national
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Safety and Glycemic Outcomes With a Tubeless Automated Insulin Delivery System in Very Young Children With Type 1 Diabetes: A Single-Arm Multicenter Clinical Trial Diabetes Care (IF 17.152) Pub Date : 2022-06-09 Jennifer L. Sherr, Bruce W. Bode, Gregory P. Forlenza, Lori M. Laffel, Melissa J. Schoelwer, Bruce A. Buckingham, Amy B. Criego, Daniel J. DeSalvo, Sarah A. MacLeish, David W. Hansen, Trang T. Ly
OBJECTIVE Very young children with type 1 diabetes often struggle to achieve glycemic targets, putting them at risk for long-term complications and creating an immense management burden for caregivers. We conducted the first evaluation of the Omnipod 5 Automated Insulin Delivery System in this population. RESEARCH DESIGN AND METHODS A total of 80 children aged 2.0–5.9 years used the investigational