-
Impact of Type 2 Diabetes on the Outcomes of Solid Organ Transplantations in the U.S.: Data From a National Registry Diabetes Care (IF 16.2) Pub Date : 2023-09-25 Maria Stepanova, Ameeta Kumar, Pamela Brandt, Nagashree Gundurao, Kenneth Cusi, Saleh Al Qahtani, Zobair M. Younossi
OBJECTIVE Type 2 diabetes (T2D) is a major driver of chronic diseases around the globe. The aim was to assess the impact of T2D on the outcomes of solid organ transplantations. RESEARCH DESIGN AND METHODS We used the Scientific Registry of Transplant Recipients from 2006 to 2021 to collect data for all patients age ≥18 years who received a lung, heart, liver, or kidney transplant in the U.S. RESULTS
-
Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies Diabetes Care (IF 16.2) Pub Date : 2023-09-25 Hsin-Fang Chung, Annette J. Dobson, Kunihiko Hayashi, Rebecca Hardy, Diana Kuh, Debra J. Anderson, Yvonne T. van der Schouw, Darren C. Greenwood, Janet E. Cade, Panayotes Demakakos, Eric J. Brunner, Sophie V. Eastwood, Sven Sandin, Elisabete Weiderpass, Gita D. Mishra
OBJECTIVE To investigate associations between age at natural menopause, particularly premature ovarian insufficiency (POI; natural menopause before age 40 years), and incident type 2 diabetes (T2D) and identify any variations by ethnicity. RESEARCH DESIGN AND METHODS We pooled individual-level data of 338,059 women from 13 cohort studies without T2D before menopause from six ethnic groups: White (n
-
National Prevalence of Diabetes and Barriers to Care Among U.S. Farmworkers and Association With Migrant Worker Status Diabetes Care (IF 16.2) Pub Date : 2023-09-22 Rose Mckeon Olson, Cody P. Nolan, Neha Limaye, Miriam Osei, Daniel Palazuelos
OBJECTIVE To quantify the prevalence of diabetes and barriers to care among U.S. migrant farmworkers (i.e. those who travel from their permanent residence for seasonal farmwork). RESEARCH DESIGN AND METHODS Age-adjusted prevalence of self-reported diabetes and barriers to care were calculated among adult U.S. farmworkers from 2008 to 2017 National Agricultural Workers Surveys. RESULTS Among 16,913
-
Alignment Between 24-h Light-Dark and Activity-Rest Rhythms Is Associated With Diabetes and Glucose Metabolism in a Nationally Representative Sample of American Adults Diabetes Care (IF 16.2) Pub Date : 2023-09-21 Qian Xiao, John Durbin, Cici Bauer, Chris Ho Ching Yeung, Mariana G. Figueiro
OBJECTIVE The alignment between environmental stimuli (e.g., dark, light) and behavior cycles (e.g., rest, activity) is an essential feature of the circadian timing system, a key contributor to metabolic health. However, no previous studies have investigated light-activity alignment in relation to glycemic control in human populations. RESEARCH DESIGN AND METHODS The analysis included ∼7,000 adults
-
Effect of Postmenopausal Hormone Therapy on Glucose Regulation in Women With Type 1 or Type 2 Diabetes: A Systematic Review and Meta-analysis Diabetes Care (IF 16.2) Pub Date : 2023-09-20 Esther M. Speksnijder, Gaby V. ten Noever de Brauw, Arjan Malekzadeh, Peter H. Bisschop, Dirk Jan Stenvers, Sarah E. Siegelaar
BACKGROUND Blood glucose regulation in women with diabetes may change during and after menopause, which could be attributed, in part, to decreased estrogen levels. PURPOSE To determine the effect of postmenopausal hormone therapy (HT) on HbA1c, fasting glucose, postprandial glucose, and use of glucose-lowering drugs in women with type 1 and women with type 2 diabetes. DATA SOURCES We conducted a systematic
-
Artificial Intelligence and Diabetic Retinopathy: AI Framework, Prospective Studies, Head-to-head Validation, and Cost-effectiveness Diabetes Care (IF 16.2) Pub Date : 2023-09-20 Anand E. Rajesh, Oliver Q. Davidson, Cecilia S. Lee, Aaron Y. Lee
Current guidelines recommend that individuals with diabetes receive yearly eye exams for detection of referable diabetic retinopathy (DR), one of the leading causes of new-onset blindness. For addressing the immense screening burden, artificial intelligence (AI) algorithms have been developed to autonomously screen for DR from fundus photography without human input. Over the last 10 years, many AI
-
Computed Tomography Versus Invasive Coronary Angiography in Patients With Diabetes and Suspected Coronary Artery Disease Diabetes Care (IF 16.2) Pub Date : 2023-09-19 Theodora Benedek, Viktoria Wieske, Bálint Szilveszter, Klaus F. Kofoed, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Josef Veselka, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca
OBJECTIVE To compare cardiac computed tomography (CT) with invasive coronary angiography (ICA) as the initial strategy in patients with diabetes and stable chest pain. RESEARCH DESIGN AND METHODS This prespecified analysis of the multicenter DISCHARGE trial in 16 European countries was performed in patients with stable chest pain and intermediate pretest probability of coronary artery disease. The
-
Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease and Diabetes Mellitus: A Subgroup Analysis of the ADAPTABLE Trial Diabetes Care (IF 16.2) Pub Date : 2023-09-15 Dennis I. Narcisse, Hwasoon Kim, Lisa M. Wruck, Amanda L. Stebbins, Daniel Muñoz, Sunil Kripalani, Mark B. Effron, Kamal Gupta, R. David Anderson, Sandeep K. Jain, Saket Girotra, Jeff Whittle, Catherine P. Benziger, Peter Farrehi, Li Zhou, Tamar S. Polonsky, Faraz S. Ahmad, Matthew T. Roe, Russell L. Rothman, Robert A. Harrington, Adrian F. Hernandez, W. Schuyler Jones
OBJECTIVE Patients with diabetes mellitus (DM) and concomitant atherosclerotic cardiovascular disease (ASCVD) must be on the most effective dose of aspirin to mitigate risk of future adverse cardiovascular events. RESEARCH DESIGN AND METHODS ADAPTABLE, an open-label, pragmatic study, randomized patients with stable, chronic ASCVD to 81 mg or 325 mg of daily aspirin. The effects of aspirin dosing was
-
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis Diabetes Care (IF 16.2) Pub Date : 2023-09-15 Ana Devesa, Valentin Fuster, Ravi Vazirani, Inés García-Lunar, Belén Oliva, Samuel España, Andrea Moreno-Arciniegas, Javier Sanz, Cristina Perez-Herreras, Héctor Bueno, Enrique Lara-Pezzi, Ana García-Alvarez, Vicente Martínez de Vega, Leticia Fernández-Friera, Maria G. Trivieri, Antonio Fernández-Ortiz, Xavier Rossello, Javier Sanchez-Gonzalez, Borja Ibanez
OBJECTIVE Experimental evidence suggests that metabolic syndrome (MetS) is associated with changes in cardiac metabolism. Whether this association occurs in humans is unknown. RESEARCH DESIGN AND METHODS 821 asymptomatic individuals from the Progression of Early Subclinical Atherosclerosis (PESA) study (50.6 [46.9–53.6] years, 83.7% male) underwent two whole-body 18F-fluorodeoxyglucose positron emission
-
Family Typology for Adults With Type 2 Diabetes: Longitudinal Stability and Validity for Diabetes Management and Well-Being Diabetes Care (IF 16.2) Pub Date : 2023-09-14 Lindsay S. Mayberry, Shilin Zhao, McKenzie K. Roddy, Andrew J. Spieker, Cynthia A. Berg, Lyndsay A. Nelson, Robert A. Greevy
OBJECTIVE We validated longitudinally a typology of diabetes-specific family functioning (named Collaborative and Helpful, Satisfied with Low Involvement, Want More Involvement, and Critically Involved) in adults with type 2 diabetes. RESEARCH DESIGN AND METHODS We conducted k-means cluster analyses with nine dimensions to determine if the typology replicated in a diverse sample and if type assignment
-
Empagliflozin Normalizes Fasting Hyperglycemia and Improves Postprandial Glucose Tolerance in Totally Pancreatectomized Patients: A Randomized, Double-Blind, Placebo-Controlled Crossover Study Diabetes Care (IF 16.2) Pub Date : 2023-09-13 Mille Baekdal, Sophie W. Nielsen, Carsten P. Hansen, Jan H. Storkholm, Gerrit van Hall, Bolette Hartmann, Jens J. Holst, Tina Vilsbøll, Asger Lund, Filip K. Knop
OBJECTIVE Insulin remains the only glucose-lowering treatment modality recommended for totally pancreatectomized patients. We investigated the effects of the sodium–glucose cotransporter 2 inhibitor empagliflozin on fasting and postprandial glucose concentrations in pancreatectomized patients and matched healthy control participants. RESEARCH DESIGN AND METHODS In a randomized, double-blind, placebo-controlled
-
Sex Differences in Age of Diagnosis, HLA Genotype, and Autoantibody Profile in Children With Type 1 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-09-12 Jasaman Tojjar, Matti Cervin, Emma Hedlund, Qefsere Brahimi, Gun Forsander, Helena Elding Larsson, Johnny Ludvigsson, Ulf Samuelsson, Claude Marcus, Martina Persson, Annelie Carlsson
OBJECTIVE To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GAD antibody [GADA], insulinoma-associated protein 2 [IA-2A], insulin autoantibody [IAA], and zinc transporter 8 autoantibody), and HLA risk. RESEARCH DESIGN AND METHODS A population-based nationwide sample of 3,645 Swedish children at T1D diagnosis
-
Comparative Cardiovascular Effectiveness and Safety of SGLT-2 Inhibitors, GLP-1 Receptor Agonists, and DPP-4 Inhibitors According to Frailty in Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-09-07 Alexander Kutz, Dae Hyun Kim, Deborah J. Wexler, Jun Liu, Sebastian Schneeweiss, Robert J. Glynn, Elisabetta Patorno
OBJECTIVE To evaluate the comparative cardiovascular effectiveness and safety of sodium–glucose cotransporter 2 inhibitors (SGLT-2is), glucagon-like peptide 1 receptor agonists (GLP-1RAs), and dipeptidyl peptidase 4 inhibitors (DPP-4is) in older adults with type 2 diabetes (T2D) across different frailty strata. RESEARCH DESIGN AND METHODS We performed three 1:1 propensity score–matched cohort studies
-
Achieving Normoglycemia With Tirzepatide: Analysis of SURPASS 1–4 Trials Diabetes Care (IF 16.2) Pub Date : 2023-09-06 Julio Rosenstock, Luis Vázquez, Stefano Del Prato, Denise Reis Franco, Govinda Weerakkody, Biyue Dai, Laura Fernández Landó, Brandon K. Bergman, Angel Rodríguez
OBJECTIVE Tirzepatide is a novel single-molecule glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, which demonstrated unprecedented improvements in glycemic control and body weight reduction, in the SURPASS phase 3 program. In this exploratory analysis, we aimed to characterize tirzepatide-treated participants who achieved HbA1c <5.7% and evaluate changes in clinical
-
Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials Diabetes Care (IF 16.2) Pub Date : 2023-08-31 Thirunavukkarasu Sathish, Kamlesh Khunti, K.M. Venkat Narayan, Viswanathan Mohan, Melanie J. Davies, Thomas Yates, Brian Oldenburg, Kavumpurathu R. Thankappan, Robyn J. Tapp, Ram Bajpai, Ranjit Mohan Anjana, Mary B. Weber, Mohammed K. Ali, Jonathan E. Shaw
OBJECTIVE To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype. RESEARCH DESIGN AND METHODS We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting
-
Declining Incidence Rates of Distal Symmetric Polyneuropathy in People With Type 1 and Type 2 Diabetes in Denmark, With Indications of Distinct Patterns in Type 1 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-08-30 Hatice Isik Mizrak, Tine Willum Hansen, Peter Rossing, Viktor Rotbain Curovic, Dorte Vistisen, Hanan Amadid, Christian Stevns Hansen
OBJECTIVE It is not known if incidence rates for diabetic distal symmetric polyneuropathy (DSPN) are decreasing, as they are for other diabetic complications. Here, we investigated incidence rates of DSPN in type 1 and type 2 diabetes in a large population-based study. RESEARCH DESIGN AND METHODS In the period 1996 to 2018, 19,342 individuals were identified at a Danish tertiary diabetes center. Vibration
-
Randomization to a Provided Higher-Complex-Carbohydrate Versus Conventional Diet in Gestational Diabetes Results in Similar Maternal 24-Hour Glycemia and Newborn Adiposity Diabetes Care (IF 16.2) Pub Date : 2023-08-29 Teri L. Hernandez, Sarah S. Farabi, Bailey K. Fosdick, Nicole Hirsch, Emily Z. Dunn, Kristy Rolloff, John P. Corbett, Elizabeth Haugen, Tyson Marden, Janine Higgins, Jacob E. Friedman, Linda A. Barbour
OBJECTIVE Nutrition therapy for gestational diabetes (GDM) has conventionally focused on carbohydrate restriction. In a randomized controlled trial (RCT), we tested the hypothesis that a diet (all meals provided) with liberalized complex carbohydrate (60%) and lower fat (25%) (CHOICE diet) could improve maternal insulin resistance and 24-h glycemia, resulting in reduced newborn adiposity (NB%fat; powered
-
Methyl Donor Nutrient Intake and Incidence of Type 2 Diabetes: Results From Three Large U.S. Cohorts Diabetes Care (IF 16.2) Pub Date : 2023-08-29 Caleigh M. Sawicki, Danielle E. Haslam, Kim V.E. Braun, Jean-Philippe Drouin-Chartier, Trudy Voortman, Oscar H. Franco, Qi Sun, Frank B. Hu, Shilpa N. Bhupathiraju
OBJECTIVE We examined whether intake of methyl donor nutrients, including vitamins B2, B6, and B12 and folate, from foods and/or supplements is associated with type 2 diabetes risk. RESEARCH DESIGN AND METHODS We included 203,644 women and men from the Nurses’ Health Study (1984–2016), Nurses’ Health Study 2 (1991–2017), and Health Professionals Follow-Up Study (1986–2016). Dietary data were collected
-
Impact of Gestational Diabetes Detection Thresholds on Infant Growth and Body Composition: A Prospective Cohort Study Within a Randomized Trial Diabetes Care (IF 16.2) Pub Date : 2023-08-29 Komal Manerkar, Caroline A. Crowther, Jane E. Harding, Michael P. Meyer, Cathryn A. Conlon, Elaine C. Rush, Jane M. Alsweiler, Lesley M.E. McCowan, Janet A. Rowan, Richard Edlin, Francesca Amitrano, Christopher J.D. McKinlay
OBJECTIVE Gestational diabetes mellitus (GDM) is associated with offspring metabolic disease, including childhood obesity, but causal mediators remain to be established. We assessed the impact of lower versus higher thresholds for detection and treatment of GDM on infant risk factors for obesity, including body composition, growth, nutrition, and appetite. RESEARCH DESIGN AND METHODS In this prospective
-
Duration of Type 2 Diabetes and Incidence of Cancer: An Observational Study in England Diabetes Care (IF 16.2) Pub Date : 2023-08-28 Francesco Zaccardi, Suping Ling, Karen Brown, Melanie Davies, Kamlesh Khunti
OBJECTIVE To investigate the association between duration of type 2 diabetes and cancer incidence. RESEARCH DESIGN AND METHODS In the Clinical Practice Research Datalink database, we identified 130,764 individuals with type 2 diabetes aged ≥35 years at diagnosis who were linked to hospital and mortality records. We used sex-stratified Royston–Parmar models with two time scales to estimate incidence
-
Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-08-28 Baojun Wu, Sook Wah Yee, Shujie Xiao, Fei Xu, Sneha B. Sridhar, Mao Yang, Samantha Hochstadt, Whitney Cabral, David E. Lanfear, Monique M. Hedderson, Kathleen M. Giacomini, L. Keoki Williams
OBJECTIVE Metformin is the most common treatment for type 2 diabetes (T2D). However, there have been no pharmacogenomic studies for T2D in which a population of color was used in the discovery analysis. This study sought to identify genomic variants associated with metformin response in African American patients with diabetes. RESEARCH DESIGN AND METHODS Patients in the discovery set were adult, African
-
All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults Diabetes Care (IF 16.2) Pub Date : 2023-08-28 Yuxia Wei, Katharina Herzog, Emma Ahlqvist, Tomas Andersson, Thomas Nyström, Yiqiang Zhan, Tiinamaija Tuomi, Sofia Carlsson
OBJECTIVE Latent autoimmune diabetes in adults (LADA) is a heterogenous, slowly progressing autoimmune diabetes. We aim to contribute new knowledge on the long-term prognosis of LADA with varying degrees of autoimmunity by comparing it to type 2 diabetes and adult-onset type 1 diabetes. RESEARCH DESIGN AND METHODS This Swedish population-based study included newly diagnosed LADA (n = 550, stratified
-
The Relationship Between Time-Varying Achieved HbA1c and Risk of Coronary Events Depends on Haptoglobin Phenotype Among White and Black ACCORD Participants Diabetes Care (IF 16.2) Pub Date : 2023-08-28 Leah E. Cahill, Rachel A. Warren, Allie S. Carew, Andrew P. Levy, Henry N. Ginsberg, John Sapp, Orit Lache, Eric B. Rimm
OBJECTIVE Intensive glycemic therapy reduced coronary artery disease (CAD) events among White participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study with the haptoglobin (Hp)2-2 phenotype, while participants without the Hp2-2 phenotype had no CAD benefit. The association between achieved glycated hemoglobin (HbA1c) and CAD for each Hp phenotype remains unknown. RESEARCH
-
Age at Type 2 Diabetes Diagnosis and Cause-Specific Mortality: Observational Study of Primary Care Patients in England Diabetes Care (IF 16.2) Pub Date : 2023-08-25 Mary M. Barker, Melanie J. Davies, Jack A. Sargeant, Juliana C.N. Chan, Edward W. Gregg, Sharmin Shabnam, Kamlesh Khunti, Francesco Zaccardi
OBJECTIVE To examine the associations between age at type 2 diabetes diagnosis and the relative and absolute risk of all-cause and cause-specific mortality in England. RESEARCH DESIGN AND METHODS In this cohort study using primary care data from the Clinical Practice Research Datalink, we identified 108,061 individuals with newly diagnosed type 2 diabetes (16–50 years of age), matched to 829,946 individuals
-
Diabetic Nephropathy: Update on Pillars of Therapy Slowing Progression Diabetes Care (IF 16.2) Pub Date : 2023-08-25 Sandra C. Naaman, George L. Bakris
Management of diabetic kidney disease (DKD) has evolved in parallel with our growing understanding of the multiple interrelated pathophysiological mechanisms that involve hemodynamic, metabolic, and inflammatory pathways. These pathways and others play a vital role in the initiation and progression of DKD. Since its initial discovery, the blockade of the renin-angiotensin system has remained a cornerstone
-
Point-of-Care Capillary Blood Ketone Measurements and the Prediction of Future Ketoacidosis Risk in Type 1 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-08-24 Cimon Song, Sharon Dhaliwal, Priya Bapat, Daniel Scarr, Abdulmohsen Bakhsh, Dalton Budram, Natasha J. Verhoeff, Alanna Weisman, Michael Fralick, Noah M. Ivers, David Z.I. Cherney, George Tomlinson, Leif Erik Lovblom, Doug Mumford, Bruce A. Perkins
OBJECTIVE Rather than during illness while diabetic ketoacidosis (DKA) is developing, we aimed to determine if levels of routine point-of-care capillary blood ketones could predict future DKA. RESEARCH DESIGN AND METHODS We examined previously collected data from placebo-assigned participants in an adjunct-to-insulin medication trial program that included measurement of fasted capillary blood ketone
-
Fully Closed-Loop Glucose Control Compared With Insulin Pump Therapy With Continuous Glucose Monitoring in Adults With Type 1 Diabetes and Suboptimal Glycemic Control: A Single-Center, Randomized, Crossover Study Diabetes Care (IF 16.2) Pub Date : 2023-08-24 Charlotte K. Boughton, Sara Hartnell, Rama Lakshman, Munachiso Nwokolo, Malgorzata E. Wilinska, Julia Ware, Janet M. Allen, Mark L. Evans, Roman Hovorka
OBJECTIVE We evaluated the safety and efficacy of fully closed-loop with ultrarapid insulin lispro in adults with type 1 diabetes and suboptimal glycemic control compared with insulin pump therapy with continuous glucose monitoring (CGM). RESEARCH DESIGN AND METHODS This single-center, randomized, crossover study enrolled 26 adults with type 1 diabetes using insulin pump therapy with suboptimal glycemic
-
Glucose Monitoring Metrics in Individuals With Type 1 Diabetes Using Different Treatment Modalities: A Real-World Observational Study Diabetes Care (IF 16.2) Pub Date : 2023-08-23 Kirsten Nørgaard, Ajenthen G. Ranjan, Christian Laugesen, Katrine G. Tidemand, Allan Green, Christian Selmer, Jannet Svensson, Henrik U. Andersen, Dorte Vistisen, Bendix Carstensen
OBJECTIVE This study aimed to investigate the association between continuous glucose monitoring (CGM)-derived glycemic metrics and different insulin treatment modalities using real-world data. RESEARCH DESIGN AND METHODS A cross-sectional study at Steno Diabetes Center Copenhagen, Denmark, included individuals with type 1 diabetes using CGM. Data from September 2021 to August 2022 were analyzed if
-
Teplizumab: A Disease-Modifying Therapy for Type 1 Diabetes That Preserves β-Cell Function Diabetes Care (IF 16.2) Pub Date : 2023-08-22 Kevan C. Herold, Stephen E. Gitelman, Peter A. Gottlieb, Laura A. Knecht, Ralph Raymond, Eleanor L. Ramos
OBJECTIVE In November 2022, teplizumab-mzwv became the first drug approved to delay the onset of stage 3 type 1 diabetes in adults and children age ≥8 years with stage 2 type 1 diabetes on the basis of data from the pivotal study TN-10. RESEARCH DESIGN AND METHODS To provide confirmatory evidence of the effects of teplizumab on preserving endogenous insulin production, an integrated analysis of C-peptide
-
Real-World Accuracy of CGM in Inpatient Critical and Noncritical Care Settings at a Safety-Net Hospital Diabetes Care (IF 16.2) Pub Date : 2023-08-10 Erin Finn, Lindsay Schlichting, Laura Grau, Ivor S. Douglas, Rocio I. Pereira
OBJECTIVE We sought to determine real-world accuracy of inpatient continuous glucose monitoring (CGM) at multiple levels of acuity in a large safety-net hospital. RESEARCH DESIGN AND METHODS We analyzed records from hospitalized patients on Dexcom G6 CGM, including clinical, point of care (POC), and laboratory (Lab) glucose, and CGM data. POC/Lab values were matched to the closest timed CGM value.
-
Genetic Evidence Strongly Supports Managing Weight and Blood Pressure in Addition to Glycemic Control in Preventing Vascular Complications in People With Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-08-09 Altayeb Ahmed, Hasnat Amin, Fotios Drenos, Naveed Sattar, Hanieh Yaghootkar
OBJECTIVE To investigate the causal association of type 2 diabetes and its components with risk of vascular complications independent of shared risk factors obesity and hypertension and to identify the main driver of this risk. RESEARCH DESIGN AND METHODS We conducted Mendelian randomization (MR) using independent genetic variants previously associated with type 2 diabetes, fasting glucose, HbA1c,
-
Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 Inhibition in Patients With Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-08-09 Filipe A. Moura, David D. Berg, Andrea Bellavia, Jamie P. Dwyer, Ofri Mosenzon, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Itamar Raz, Mark W. Feinberg, Eugene Braunwald, David A. Morrow, Marc S. Sabatine
OBJECTIVE To develop a risk assessment tool to identify patients with type 2 diabetes (T2D) at higher risk for kidney disease progression and who might benefit more from sodium–glucose cotransporter 2 (SGLT2) inhibition. RESEARCH DESIGN AND METHODS A total of 41,204 patients with T2D from four Thrombolysis In Myocardial Infarction (TIMI) clinical trials were divided into derivation (70%) and validation
-
Leisure-Time Physical Activity and Risk of Microvascular Complications in Individuals With Type 2 Diabetes: A UK Biobank Study Diabetes Care (IF 16.2) Pub Date : 2023-08-07 Frederik Pagh Bredahl Kristensen, Miguel Adriano Sanchez-Lastra, Knut Eirik Dalene, Borja del Pozo Cruz, Mathias Ried-Larsen, Reimar Wernich Thomsen, Ding Ding, Ulf Ekelund, Jakob Tarp
OBJECTIVE The aim of this study was to determine dose-response associations, including the minimal effective level, between leisure-time physical activity and risk of incident neuropathy, nephropathy, and retinopathy. RESEARCH DESIGN AND METHODS This cohort study included 18,092 individuals with type 2 diabetes from the UK Biobank. Self-reported leisure-time physical activity was converted into MET-hours
-
Residual β-Cell Function Is Associated With Longer Time in Range in Individuals With Type 1 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-08-03 Coco M. Fuhri Snethlage, Timothy J. McDonald, Richard D. Oram, Pleun de Groen, Elena Rampanelli, Alinda W.M. Schimmel, Frits Holleman, Sarah Siegelaar, Joost Hoekstra, Catherine B. Brouwer, Filip K. Knop, C. Bruce Verchere, Daniël H. van Raalte, Bart O. Roep, Max Nieuwdorp, Nordin M.J. Hanssen
OBJECTIVE Little is known about the influence of residual islet function on glycemic control in type 1 diabetes (T1D). We investigated the associations between residual β-cell function and metrics of continuous glucose monitoring (CGM) in individuals with T1D. RESEARCH DESIGN AND METHODS In this cross-sectional cohort comprising 489 individuals (64% female, age 41.0 ± 14.0 years), T1D duration was
-
Associations of Habitual Calcium Supplementation With Risk of Cardiovascular Disease and Mortality in Individuals With and Without Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-07-28 Zixin Qiu, Qi Lu, Zhenzhen Wan, Tingting Geng, Rui Li, Kai Zhu, Lin Li, Xue Chen, An Pan, JoAnn E. Manson, Gang Liu
OBJECTIVE To prospectively examine the associations of habitual calcium supplementation with cardiovascular disease (CVD) events and mortality in individuals with and without diabetes. RESEARCH DESIGN AND METHODS The main analysis included 434,674 participants from the UK Biobank. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs. Interactions of calcium
-
Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-07-28 Deborah Osafehinti, Surya N. Mulukutla, Christiane S. Hampe, Ruchi Gaba, Nalini Ram, Michael N. Weedon, Richard A. Oram, Ashok Balasubramanyam
OBJECTIVE To determine whether genetic risk for type 1 diabetes (T1D) differentiates the four Aβ subgroups of ketosis-prone diabetes (KPD), where A+ and A− define the presence or absence of islet autoantibodies and β+ and β− define the presence or absence of β-cell function. RESEARCH DESIGN AND METHODS We compared T1D genetic risk scores (GRSs) of patients with KPD across subgroups, race/ethnicity
-
Relationship Between Symptom Perception and Postprandial Glycemic Profiles in Patients With Postbariatric Hypoglycemia After Roux-en-Y Gastric Bypass Surgery Diabetes Care (IF 16.2) Pub Date : 2023-07-27 Afroditi Tripyla, Antonio Ferreira, Katja A. Schönenberger, Noah H. Näf, Lukas E. Inderbitzin, Francesco Prendin, Luca Cossu, Giacomo Cappon, Andrea Facchinetti, David Herzig, Lia Bally
OBJECTIVE Post–bariatric surgery hypoglycemia (PBH) is a metabolic complication of Roux-en-Y gastric bypass (RYGB). Since symptoms are a key component of the Whipple’s triad to diagnose nondiabetic hypoglycemia, we evaluated the relationship between self-reported symptoms and postprandial sensor glucose profiles. RESEARCH DESIGN AND METHODS Thirty patients with PBH after RYGB (age: 50.1 [41.6–60.6]
-
Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-07-26 Jared G. Maina, Zhanna Balkhiyarova, Arie Nouwen, Igor Pupko, Anna Ulrich, Mathilde Boissel, Amélie Bonnefond, Philippe Froguel, Amna Khamis, Inga Prokopenko, Marika Kaakinen
OBJECTIVE Depression is a common comorbidity of type 2 diabetes. We assessed the causal relationships and shared genetics between them. RESEARCH DESIGN AND METHODS We applied two-sample, bidirectional Mendelian randomization (MR) to assess causality between type 2 diabetes and depression. We investigated potential mediation using two-step MR. To identify shared genetics, we performed 1) genome-wide
-
Depressive Symptoms Longitudinally Mediate the Effect of Hyperglycemia on Memory Decline in Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-07-25 A. Zarina Kraal, Vicki L. Ellingrod, Laura B. Zahodne
OBJECTIVE We sought to examine the mediating role of changes in depressive symptoms in the association between chronic hyperglycemia and longitudinal cognition in a sample of older adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a longitudinal mediation analysis using structural equation modeling of observational data collected over 6 years from 2,155 participants with T2D
-
Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort Diabetes Care (IF 16.2) Pub Date : 2023-07-25 Charlotte Debras, Mélanie Deschasaux-Tanguy, Eloi Chazelas, Laury Sellem, Nathalie Druesne-Pecollo, Younes Esseddik, Fabien Szabo de Edelenyi, Cédric Agaësse, Alexandre De Sa, Rebecca Lutchia, Chantal Julia, Emmanuelle Kesse-Guyot, Benjamin Allès, Pilar Galan, Serge Hercberg, Inge Huybrechts, Emmanuel Cosson, Sopio Tatulashvili, Bernard Srour, Mathilde Touvier
OBJECTIVE To study the relationships between artificial sweeteners, accounting for all dietary sources(total and by type of artificial sweetener) and risk of type 2 diabetes (T2D), in a large-scale prospective cohort. RESEARCH DESIGN AND METHODS The analyses included 105,588 participants from the web-based NutriNet-Santé study (France, 2009–2022; mean age 42.5 ± 14.6 years, 79.2% women). Repeated 24-h
-
Assessment of Meal Anticipation for Improving Fully Automated Insulin Delivery in Adults With Type 1 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-07-21 Jose Garcia-Tirado, Patricio Colmegna, Orianne Villard, Jenny L. Diaz, Rebeca Esquivel-Zuniga, Chaitanya L. K. Koravi, Charlotte L. Barnett, Mary C. Oliveri, Morgan Fuller, Sue A. Brown, Mark D. DeBoer, Marc D. Breton
OBJECTIVE Meals are a consistent challenge to glycemic control in type 1 diabetes (T1D). Our objective was to assess the glycemic impact of meal anticipation within a fully automated insulin delivery (AID) system among adults with T1D. RESEARCH DESIGN AND METHODS We report the results of a randomized crossover clinical trial comparing three modalities of AID systems: hybrid closed loop (HCL), full
-
A Skin Care Program to Prevent Skin Problems due to Diabetes Devices in Children and Adolescents: A Cluster-Controlled Intervention Study Diabetes Care (IF 16.2) Pub Date : 2023-07-21 Anna Korsgaard Berg, Annemarie Cecilie Grauslund, Fiona Sørensen, Steffen Ullitz Thorsen, Jacob P. Thyssen, Claus Zachariae, Jannet Svensson
OBJECTIVE Diabetes devices that deliver insulin and measure blood glucose levels are cornerstones in modern treatment of type 1 diabetes. However, their use is frequently associated with the development of skin problems, particularly eczema and wounds. Proper skin care may prevent skin problems, yet evidence-based information from interventional studies is missing. Providing this information is the
-
Long-term Effectiveness of the National Diabetes Quality Assessment Program in South Korea Diabetes Care (IF 16.2) Pub Date : 2023-07-20 Ji Hye Huh, Serim Kwon, Gui Ok Kim, Bo Yeon Kim, Kyoung Hwa Ha, Dae Jung Kim
OBJECTIVE This study examined the long-term effectiveness of the national diabetes quality assessment program (NDQAP) in diabetes. RESEARCH DESIGN AND METHODS From the Health Insurance Review and Assessment Service database, 399,984 individuals with diabetes who visited a primary care clinic from 1 July 2012 to 30 June 2013 were included and followed up until 31 May 2021. The NDQAP included five quality
-
The Growing Role of Technology in the Care of Older Adults With Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-07-20 Elbert S. Huang, Alan Sinclair, Paul R. Conlin, Tali Cukierman-Yaffe, Irl B. Hirsch, Megan Huisingh-Scheetz, Anna R. Kahkoska, Lori Laffel, Alexandra K. Lee, Sei Lee, Kasia Lipska, Graydon Meneilly, Naushira Pandya, Monica E. Peek, Anne Peters, Richard E. Pratley, Diana Sherifali, Elena Toschi, Guillermo Umpierrez, Ruth S. Weinstock, Medha Munshi
The integration of technologies such as continuous glucose monitors, insulin pumps, and smart pens into diabetes management has the potential to support the transformation of health care services that provide a higher quality of diabetes care, lower costs and administrative burdens, and greater empowerment for people with diabetes and their caregivers. Among people with diabetes, older adults are a
-
A Road Map for Peer Review of Real-World Evidence Studies on Safety and Effectiveness of Treatments Diabetes Care (IF 16.2) Pub Date : 2023-07-20 Almut G. Winterstein, Vera Ehrenstein, Jeffrey S. Brown, Til Stürmer, Meredith Y. Smith
The growing acceptance of real-world evidence (RWE) in clinical and regulatory decision-making, coupled with increasing availability of health care data and advances in automated analytic approaches, has contributed to a marked expansion of RWE studies of diabetes and other diseases. However, a recent spate of high-profile retractions highlights the need for improvements in the conduct of RWE research
-
Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Diabetes Care (IF 16.2) Pub Date : 2023-07-20 David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea R. Horvath, Åke Lernmark, Boyd E. Metzger, David M. Nathan, M. Sue Kirkman
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled evidence-based recommendations for laboratory analysis in patients with diabetes. The overall quality of the evidence and the strength of the recommendations were
-
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Diabetes Care (IF 16.2) Pub Date : 2023-07-20 David B. Sacks, Mark Arnold, George L. Bakris, David E. Bruns, Andrea R. Horvath, Åke Lernmark, Boyd E. Metzger, David M. Nathan, M. Sue Kirkman
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH An expert committee compiled evidence-based recommendations for laboratory analysis in screening, diagnosis, or monitoring of diabetes. The overall quality of the evidence and the strength of the
-
Diet-Related Lipidomic Signatures and Changed Type 2 Diabetes Risk in a Randomized Controlled Feeding Study With Mediterranean Diet and Traditional Chinese or Transitional Diets Diabetes Care (IF 16.2) Pub Date : 2023-07-18 Yaogan Luo, Liang Sun, Qingqing Wu, Boyu Song, Yanpu Wu, Xiaowei Yang, Puchen Zhou, Zhenhua Niu, He Zheng, Huaixing Li, Weiqiong Gu, Jiqiu Wang, Guang Ning, Rong Zeng, Xu Lin
OBJECTIVE Few trials studied the links of food components in different diets with their induced lipidomic changes and related metabolic outcomes. Thus, we investigated specific lipidomic signatures with habitual diets and modified diabetes risk by using a trial and a cohort. RESEARCH DESIGN AND METHODS We included 231 Chinese with overweight and prediabetes in a randomized feeding trial with Mediterranean
-
Association Between Diabetes Technology Use and Glycemic Outcomes in Adults With Type 1 Diabetes Over a Decade Diabetes Care (IF 16.2) Pub Date : 2023-07-17 Kagan E. Karakus, Halis K. Akturk, G. Todd Alonso, Janet K. Snell-Bergeon, Viral N. Shah
OBJECTIVE To evaluate change in mean clinic HbA1c from 2014 to 2021 with diabetes technology use in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS In this single-center study, we analyzed diabetes technology use and mean clinic HbA1c among unique adults (age ≥18 years) with type 1 diabetes (last visit of the year per patient) between 1 January 2014 and 31 December 2021 from the electronic
-
A Randomized Controlled Trial Comparing the Efficacy and Safety of IDegLira Versus Basal-Bolus in Patients With Poorly Controlled Type 2 Diabetes and Very High HbA1c ≥9–15%: DUAL HIGH Trial Diabetes Care (IF 16.2) Pub Date : 2023-07-17 Rodolfo J. Galindo, Bobak Moazzami, Maria F. Scioscia, Cesar Zambrano, Bonnie S. Albury, Jarrod Saling, Priyathama Vellanki, Francisco J. Pasquel, Georgia M. Davis, Maya Fayfman, Limin Peng, Guillermo E. Umpierrez
OBJECTIVE In participants with type 2 diabetes (T2D) and HbA1c >9.0–10.0%, guidelines recommend treatment with basal-bolus insulin. RESEARCH DESIGN AND METHODS This randomized trial compared the efficacy and safety of insulin degludec and liraglutide (IDegLira) and basal-bolus among participants with high HbA1c ≥9.0–15.0%, previously treated with 2 or 3 oral agents and/or basal insulin, allocated (1:1)
-
Evaluation of Insulin Pump Infusion Sites in Type 1 Diabetes: The DERMIS Study Diabetes Care (IF 16.2) Pub Date : 2023-07-14 Andrea Kalus, Michi M. Shinohara, Ruikang Wang, Jesica D. Baran, Xiaofu Dong, Dori Khakpour, Jie Lu, Irl B. Hirsch
OBJECTIVE Continuous subcutaneous insulin infusion (CSII) for type 1 diabetes is increasing in use. Pump site failures are common, but little is known about skin changes from pump use. Using noninvasive optical coherence tomography (OCT), OCT angiography (OCTA), and skin biopsies, we evaluated skin changes from chronic insulin infusion. RESEARCH DESIGN AND METHODS In this cross-sectional study, OCT
-
Grading Fractures on Foot and Ankle X-rays and MRI Scans in the Active Charcot Foot in Diabetes: How Strong Is the Agreement Between Modalities? Diabetes Care (IF 16.2) Pub Date : 2023-07-12 Oliver Artz, Lisa Meacock, David A. Elias, Michael E. Edmonds, Nina L. Petrova
OBJECTIVE To compare X-ray and MRI as diagnostic tests of active Charcot neuro-osteoarthropathy (CNO) in diabetes. RESEARCH DESIGN AND METHODS X-rays and MRI scans of 48 participants were rated for severity of fracture (0 = no fracture, 1 = fracture, 2 = collapse/fragmentation), and for absence/presence of bone marrow edema (BME) on MRI and absence/presence of bone injury on X-ray. The agreement between
-
Time Trends in the Incidence of Diabetic Ketoacidosis Leading to Hospital Admission Among Adults With Type 1 Diabetes—A Nationwide Danish Register Study Diabetes Care (IF 16.2) Pub Date : 2023-07-11 Elisabeth B. Stougaard, Hanan Amadid, Esben Søndergaard, Bendix Carstensen, Marit E. Jørgensen, Kirsten Nørgaard, Peter Rossing, Frederik Persson, Dorte Vistisen
OBJECTIVE Diabetic ketoacidosis (DKA) is a life-threatening but preventable complication in people with type 1 diabetes. We aimed to quantify the incidence of DKA according to age and describe the time trend of DKA among adults with type 1 diabetes in Denmark. RESEARCH DESIGN AND METHODS Individuals aged ≥18 years with type 1 diabetes were identified from a nationwide Danish diabetes register. Hospital
-
Glycemic Measures in Childhood as Predictors of Future Diabetes-Related Microvascular Complications in an Indigenous American Population Diabetes Care (IF 16.2) Pub Date : 2023-07-11 Laura Vazquez, Elsa Vazquez Arreola, Robert L. Hanson, Madhumita Sinha
OBJECTIVE To examine the role of glycemic measures performed during childhood in predicting future diabetes-related nephropathy and retinopathy in a high-risk indigenous American cohort. RESEARCH DESIGN AND METHODS We studied associations between glycated hemoglobin (HbA1c) and 2-h plasma glucose (PG), measured during childhood (age 5 to <20 years) in a longitudinal observational study of diabetes
-
Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-World Population-Based Study in Subjects With Type 2 Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-07-10 Rafael Simó, Josep Franch-Nadal, Bogdan Vlacho, Jordi Real, Ester Amado, Juana Flores, Manel Mata-Cases, Emilio Ortega, Mercedes Rigla, Joan-Anton Vallés, Cristina Hernández, Didac Mauricio
OBJECTIVE Early worsening of diabetic retinopathy (EWDR) due to the rapid decrease of blood glucose levels is a concern in diabetes treatment. The aim of the current study is to evaluate whether this is an important issue in subjects with type 2 diabetes with mild or moderate nonproliferative DR (NPDR), who represent the vast majority of subjects with DR attended in primary care. RESEARCH DESIGN AND
-
Relationship Among Diabetes, Obesity, and Cardiovascular Disease Phenotypes: A UK Biobank Cohort Study Diabetes Care (IF 16.2) Pub Date : 2023-06-27 Oliver I. Brown, Michael Drozd, Hugo McGowan, Marilena Giannoudi, Marcella Conning-Rowland, John Gierula, Sam Straw, Stephen B. Wheatcroft, Katherine Bridge, Lee D. Roberts, Eylem Levelt, Ramzi Ajjan, Kathryn J. Griffin, Marc A. Bailey, Mark T. Kearney, Richard M. Cubbon
OBJECTIVE Obesity and diabetes frequently coexist, yet their individual contributions to cardiovascular risk remain debated. We explored cardiovascular disease biomarkers, events, and mortality in the UK Biobank stratified by BMI and diabetes. RESEARCH DESIGN AND METHODS A total of 451,355 participants were stratified by ethnicity-specific BMI categories (normal, overweight, obese) and diabetes status
-
Addendum. 3. Prevention or Delay of Type 2 Diabetes and Associated Comorbidities: Standards of Care in Diabetes—2023. Diabetes Care 2023;46(Suppl. 1):S41–S48 Diabetes Care (IF 16.2) Pub Date : 2023-06-25 Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Section 3, “Prevention or Delay of Type 2 Diabetes and Associated Comorbidities,” of the Standards of Care in Diabetes—2023 has been updated based on recent U.S. Food and Drug Administration approval of a new drug to delay the incidence of type 1 diabetes. The online version of the article (https://doi.org/10.2337/dc23-S003) reflects the changes described below. Jason L. Gaglia, of Joslin Diabetes
-
Addendum. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2023. Diabetes Care 2023;46(Suppl. 1):S19–S40 Diabetes Care (IF 16.2) Pub Date : 2023-06-25 Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Section 2, “Classification and Diagnosis of Diabetes,” of the Standards of Care in Diabetes—2023 has been updated to refine the diagnostic criteria for type 1 diabetes based on recent U.S. Food and Drug Administration approval of a new drug to delay the incidence of type 1 diabetes. The online version of the article (https://doi.org/10.2337/dc23-S002) reflects the changes described below. Jason L.
-
Food Insecurity and Diabetes: Overview of Intersections and Potential Dual Solutions Diabetes Care (IF 16.2) Pub Date : 2023-06-24 Ronli Levi, Sara N. Bleich, Hilary K. Seligman
Food insecurity increases the risk of developing diabetes and its complications. In this article, we describe the complex relationship that exists between food insecurity and diabetes and describe potential mechanisms that may underlie this association. We then describe how two different types of interventions, food-is-medicine and federal nutrition assistance programs, may help address both food insecurity
-
Overview of Social Determinants of Health in the Development of Diabetes Diabetes Care (IF 16.2) Pub Date : 2023-06-24 Felicia Hill-Briggs, Stephanie L. Fitzpatrick
To guide effective planning and decision-making regarding strategies to address adverse social determinants of health (SDOH) in diabetes, an understanding of upstream drivers and root causes is imperative. The World Health Organization SDOH framework includes socioeconomic and political systems and racism as upstream drivers of SDOH. These factors are not currently included in the Healthy People 2030