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Arterial Stiffness Is Related to Diabetes-Associated Microvascular Complications: The SEARCH for Diabetes in Youth Study Diabetes Care (IF 14.8) Pub Date : 2025-02-14 Ryan P. Brady, Elaine M. Urbina, Zhiqian Gao, Dana Dabelea, Eva Lustigova, Santica Marcovina, Amy K. Mottl, Catherine Pihoker, Kristi Reynolds, LeAnne Sancrainte, Lawrence M. Dolan, Amy S. Shah
OBJECTIVE To assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents and young adults with youth-onset diabetes. RESEARCH DESIGN AND METHODS This study included 1,226 individuals (median age at initial visit 18 years; 58% female; 53% non-Hispanic White, 22% non-Hispanic Black, and 20% Hispanic) with
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Longitudinal Determination of Diabetes Complications and Other Clinical Variables as Risk Factors for Diabetic Ketoacidosis in Type 1 Diabetes Diabetes Care (IF 14.8) Pub Date : 2025-02-14 Priya Bapat, Dalton R. Budhram, Abdulmohsen Bakhsh, Mohammad I. Abuabat, Natasha J. Verhoeff, Doug Mumford, Wajeeha Cheema, Cesar Falappa, Andrej Orszag, Akshay Jain, David Z.I. Cherney, Michael Fralick, Alanna Weisman, George Tomlinson, Leif Erik Lovblom, Bruce A. Perkins
OBJECTIVE We aimed to determine whether diabetes complications, such as kidney disease that may impair acid-base buffering capacity, independently predict the risk of subsequent diabetic ketoacidosis (DKA). RESEARCH DESIGN AND METHODS We accessed previously collected 34-year data from the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications study through
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The Glycemic Impact of Protein Ingestion in People With Type 1 Diabetes Diabetes Care (IF 14.8) Pub Date : 2025-02-14 Giang M. Dao, Greg M. Kowalski, Clinton R. Bruce, David N. O’Neal, Carmel E. Smart, Dessi P. Zaharieva, Declan T. Hennessy, Sam Zhao, Dale J. Morrison
In individuals with type 1 diabetes, carbohydrate is commonly recognized as the primary macronutrient influencing postprandial glucose levels. Accumulating evidence indicates that protein ingestion also contributes to the increment in postprandial glucose levels, despite endocrine and metabolic responses different from those with carbohydrate ingestion. However, findings regarding protein ingestion’s
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Islet Transplantation Versus Standard of Care for Type 1 Diabetes Complicated by Severe Hypoglycemia From the Collaborative Islet Transplant Registry and the T1D Exchange Registry Diabetes Care (IF 14.8) Pub Date : 2025-02-14 Michael R. Rickels, Cassandra M. Ballou, Nicole C. Foster, Rodolfo Alejandro, David A. Baidal, Melena D. Bellin, Thomas L. Eggerman, Bernhard J. Hering, Fouad Kandeel, Adam Brand, Kellee M. Miller, Franca B. Barton, Elizabeth H. Payne
OBJECTIVE Islet transplantation was recently US Food and Drug Administration approved for adults with type 1 diabetes complicated by recurrent severe hypoglycemia events (SHEs). We sought to understand the long-term benefit for glycemic control and risk of immunosuppression to kidney function associated with islet transplantation compared with ongoing standard of care. RESEARCH DESIGN AND METHODS We
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Association Between Self-Monitored Blood Glucose and Continuous Glucose Monitoring in Youth With Type 1 Diabetes and Medicaid Insurance Diabetes Care (IF 14.8) Pub Date : 2025-02-14 Janice Chan, Nicholas Jackson, Arianna Gonzalez Rebollar, Cynthia Santana, Giselle Perez de la Garza, Tannaz Moin, Jennifer K. Yee, Estelle Everett
OBJECTIVE Youth with type 1 diabetes (T1D) and Medicaid must demonstrate they have self-monitored their blood glucose level at least four times daily to receive continuous glucose monitors (CGMs). New California Medicaid policies eliminated this requirement and, thus, CGM access has increased. This study examines whether infrequent baseline self-monitored blood glucose (SMBG) checks result in suboptimal
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Association of Historical Redlining With Gestational Diabetes Mellitus: The Mediating Role of BMI and Area Deprivation Index Diabetes Care (IF 14.8) Pub Date : 2025-02-12 Wajeeha Umer, Yi Sun, Anqi Jiao, Karen D. Lincoln, Mengyi Li, Chantal C. Avila, Vicki Y. Chiu, Jeff M. Slezak, David A. Sacks, John Molitor, Tarik Benmarhnia, Jiu-Chiuan Chen, Darios Getahun, Jun Wu
OBJECTIVE We investigated the association between historic redlining and risk of gestational diabetes mellitus (GDM), and whether this relationship is mediated by maternal obesity and area-level deprivation. RESEARCH DESIGN AND METHODS This retrospective study included 86,834 singleton pregnancies from Kaiser Permanente Southern California’s health records (2008–2018). Redlining was assessed using
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Lung Function Impairment and Risks of Incident Cardiovascular Diseases and Mortality Among People With Type 2 Diabetes: A Prospective Cohort Study Diabetes Care (IF 14.8) Pub Date : 2025-02-11 Chaolei Chen, Zehan Huang, Lin Liu, Bingbing Su, Yingqing Feng, Yuqing Huang
OBJECTIVE Individuals with type 2 diabetes (T2D) frequently exhibit impaired lung function, potentially accelerating the onset of cardiovascular disease (CVD), although prospective studies remain limited. We aimed to explore the relationship between lung function impairment and risk of CVD and mortality within this high-risk population. RESEARCH DESIGN AND METHODS This prospective study included 16
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Understanding the Impact of Diabetic Peripheral Neuropathy and Neuropathic Pain on Quality of Life and Mental Health in 6,960 People With Diabetes Diabetes Care (IF 14.8) Pub Date : 2025-02-11 Mette Krabsmark Borbjerg, Anne-Marie Wegeberg, Amar Nikontovic, Carsten Dahl Mørch, Lars Arendt-Nielsen, Niels Ejskjaer, Christina Brock, Peter Vestergaard, Johan Røikjer
OBJECTIVE Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts quality of life (QoL) and mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful and painless DPN and QoL, mental health, and socioeconomic factors, 2) assess the prevalence of sensory pain descriptors, and 3) evaluate the association between descriptors and the above
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Sex-Specific Blood Pressure Trajectories and Cardiovascular Disease in Type 1 Diabetes: 32-Year Follow-up of the Pittsburgh Epidemiology of Diabetes Complications Cohort Diabetes Care (IF 14.8) Pub Date : 2025-02-11 Rachel G. Miller, Trevor J. Orchard, Tina Costacou
OBJECTIVE We examined sex differences in longitudinal blood pressure (BP) and 32-year cardiovascular disease (CVD) incidence in the Pittsburgh Epidemiology of Diabetes Complications type 1 diabetes cohort. RESEARCH DESIGN AND METHODS BP was measured up to nine (median six) times between 1986–1988 baseline and 2016–2018; n = 300 women and 304 men without CVD at baseline were followed until December
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The Burden of Diabetes Mortality by County, Race, and Ethnicity in the U.S., 2000–2019 Diabetes Care (IF 14.8) Pub Date : 2025-02-10 Hasan Nassereldine, Zhuochen Li, Kelly Compton, Parkes Kendrick, Ethan Kahn, Yekaterina O. Kelly, Mathew M. Baumann, Chris A. Schmidt, Dillon O. Sylte, Kanyin Liane Ong, Wichada La Motte-Kerr, Farah Daoud, Susan A. McLaughlin, Simon I. Hay, Erik J. Rodriquez, Anna M. Nápoles, George A. Mensah, Eliseo J. Pérez-Stable, Ali H. Mokdad, Laura Dwyer-Lindgren
OBJECTIVE Diabetes is a leading cause of death in the U.S. Previous studies have found substantial racial, ethnic, and geographical disparities in diabetes mortality; however, research considering racial, ethnic, and geographical disparities simultaneously has been limited. To fill this gap, we estimated trends in diabetes mortality rates from 2000 to 2019 at the county level for five racial and ethnic
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Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial Diabetes Care (IF 14.8) Pub Date : 2025-02-06 Gregory G. Schwartz, Michael Szarek, J. Wouter Jukema, Christa M. Cobbaert, Esther Reijnders, Vera A. Bittner, Markus Schwertfeger, Deepak L. Bhatt, Sergio Fazio, Genevieve Garon, Shaun G. Goodman, Robert A. Harrington, Harvey D. White, Philippe Gabriel Steg
OBJECTIVE Previous genetic and clinical analyses have associated lower lipoprotein(a) and LDL cholesterol (LDL-C) with greater risk of new-onset type 2 diabetes (NOD). However, PCSK9 inhibitors such as alirocumab lower both lipoprotein(a) and LDL-C without effect on NOD. RESEARCH DESIGN AND METHODS In a post hoc analysis of the ODYSSEY OUTCOMES trial (NCT01663402), we examined the joint prediction
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Health-Related Quality of Life and Health Utility After Metabolic/Bariatric Surgery Versus Medical/Lifestyle Intervention in Individuals With Type 2 Diabetes and Obesity: The ARMMS-T2D Study Diabetes Care (IF 14.8) Pub Date : 2025-02-04 Donald C. Simonson, William F. Gourash, David E. Arterburn, Bo Hu, Sangeeta R. Kashyap, David E. Cummings, Mary-Elizabeth Patti, Anita P. Courcoulas, Ashley H. Vernon, John M. Jakicic, Sarah Kirschling, Ali Aminian, Philip R. Schauer, John P. Kirwan
OBJECTIVE Type 2 diabetes and obesity are associated with reduced health-related quality of life (HRQoL) and health utility (HU), but long-term effects of metabolic/bariatric surgery (MBS) compared with those of medical/lifestyle intervention (MLI) on these outcomes are unclear. RESEARCH DESIGN AND METHODS We studied 228 individuals with type 2 diabetes and obesity randomly assigned to MBS (Roux-en-Y
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Short-Term Metformin Protects Against Glucocorticoid-Induced Toxicity in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial Diabetes Care (IF 14.8) Pub Date : 2025-02-03 Susanne Thierry, Caspar Joyce Peterson, Stéphanie Pfammatter, Patricia Arroyo Tardio, Christian Meier, Tarik Delko, Vasco Iten, Christine S. Zuern, Michael Kühne, Michael Epstein, Alaa Othman, Nicola Zamboni, Isabel Reinisch, Adhideb Ghosh, Christian Wolfrum, Eleonora Seelig
OBJECTIVE Glucocorticoids (GCs) are potent anti-inflammatory drugs, but strategies to prevent side effects are lacking. We investigated whether metformin could prevent GC-related toxicity and explored the underlying mechanisms. RESEARCH DESIGN AND METHODS This single-center, randomized, placebo-controlled, double-blind, crossover trial compared metformin with placebo during high-dose GC treatment in
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In-Hospital Diabetes Management by a Diabetes Team and Insulin Titration Algorithms Based on Continuous Glucose Monitoring or Point-of-Care Glucose Testing in Patients With Type 2 Diabetes (DIATEC): A Randomized Controlled Trial Diabetes Care (IF 14.8) Pub Date : 2025-01-31 Mikkel T. Olsen, Carina K. Klarskov, Signe H. Jensen, Louise M. Rasmussen, Birgitte Lindegaard, Jonas A. Andersen, Hans Gottlieb, Suzanne Lunding, Ulrik Pedersen-Bjergaard, Katrine B. Hansen, Peter L. Kristensen
OBJECTIVE The DIATEC trial investigates the glycemic and clinical effects of inpatient continuous glucose monitoring (CGM)–guided insulin titration by diabetes teams. RESEARCH DESIGN AND METHODS This two-center trial randomized 166 non–intensive care unit patients with type 2 diabetes. Diabetes management was performed by regular staff, guided by diabetes teams using insulin titration algorithms based
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Screening for Metabolic Dysfunction–Associated Steatotic Liver Disease–Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study Diabetes Care (IF 14.8) Pub Date : 2025-01-31 Cyrielle Caussy, Bruno Vergès, Damien Leleu, Laurence Duvillard, Fabien Subtil, Amna Abichou-Klich, Valérie Hervieu, Laurent Milot, Bérénice Ségrestin, Sylvie Bin, Alexia Rouland, Dominique Delaunay, Pierre Morcel, Samy Hadjadj, Claire Primot, Jean-Michel Petit, Sybil Charrière, Philippe Moulin, Massimo Levrero, Bertrand Cariou, Emmanuel Disse
OBJECTIVE Screening for advanced fibrosis (AF) resulting from metabolic dysfunction–associated steatotic liver disease (MASLD) is recommended in diabetology. This study aimed to compare the performance of noninvasive tests (NITs) with that of two-step algorithms for detecting patients at high risk of AF requiring referral to hepatologists. RESEARCH DESIGN AND METHODS We conducted a planned interim
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Islet Autoantibody Screening Throughout Australia Using In-Home Blood Spot Sampling: 2-Year Outcomes of Type1Screen Diabetes Care (IF 14.8) Pub Date : 2025-01-29 John M. Wentworth, Anna B. E. Sing, Gaetano Naselli, Dexing Huang, Elizabeth Azidis-Yates, Batsho Mandlebe, James D. Brown, Kelly McGorm, Candice Hall, Leanne Redl, Renee Kludas, Aniruddh Haldar, Felicity Healy, Abbey Gilbert, Kelly Watson, Cherie Chiang, Jennifer J. Couper, Tony Huynh, Elizabeth A. Davis, Maria E. Craig, Fergus J. Cameron, Thomas W. Kay, Leonard C. Harrison, Peter G. Colman
OBJECTIVE Type1Screen offers islet autoantibody testing to Australians with a family history of type 1 diabetes (T1D) with the dual aims of preventing diabetic ketoacidosis (DKA) and enabling use of disease-modifying therapy. We describe screening and monitoring outcomes 2 years after implementing in-home capillary blood spot sampling. RESEARCH DESIGN AND METHODS Data from 2,064 participants who registered
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Longitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With Gestational Diabetes Mellitus History Diabetes Care (IF 14.8) Pub Date : 2025-01-28 Ni Kang, Wu Chen, Nosa Osazuwa, Chenyu Qiu, Julianne Cook Botelho, Antonia M. Calafat, Dean Jones, Thomas Buchanan, Anny H. Xiang, Zhanghua Chen
OBJECTIVE We investigated associations between per- and polyfluoroalkyl substances (PFAS) and changes in diabetes indicators from pregnancy to 12 years after delivery among women with a history of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS Eighty Hispanic women with GDM history were followed from the third trimester of pregnancy to 12 years after delivery. Oral and intravenous
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Diabetes Risk After Treatment for Childhood and Young Adult Cancer Diabetes Care (IF 14.8) Pub Date : 2025-01-24 Kirsten J. Cromie, Robert D. Murray, Ramzi A. Ajjan, Nicola F. Hughes, Richard G. Feltbower, Adam W. Glaser
OBJECTIVE Diabetes is a potential late consequence of childhood and young adult cancer (CYAC) treatment. Causative treatments associated with diabetes have been identified in retrospective cohort studies but have not been validated in population-based cohorts. Our aim was to define the extent of diabetes risk and explore contributory factors for its development in survivors of CYAC in the United Kingdom
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Additive Value of Polygenic Risk Score to Family History for Type 2 Diabetes Prediction: Results From the All of Us Research Database Diabetes Care (IF 14.8) Pub Date : 2025-01-22 Emily Drzymalla, Laura Raffield, Katherine Kolor, Alain Koyama, Ramal Moonesinghe, Meda E. Pavkov, Cassandra N. Spracklen, Muin J. Khoury
OBJECTIVE The goal of this study was to assess the additive value of considering type 2 diabetes (T2D) polygenic risk score (PRS) in addition to family history for T2D prediction. RESEARCH DESIGN AND METHODS Data were obtained from the All of Us (AoU) research database. First-degree T2D family history was self-reported on the personal family history health questionnaire. A PRS was constructed from
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Lessons Learned From Epidemiology of Type 2 Diabetes in South Asians: Kelly West Award Lecture 2024 Diabetes Care (IF 14.8) Pub Date : 2025-01-22 Viswanathan Mohan
South Asia has high prevalence rates of type 2 diabetes (T2D). Until the 1990s, the prevalence of T2D within South Asia was low but much higher in the South Asian diaspora living abroad. Today, high prevalence rates of T2D are reported among those living in South Asia. T2D in South Asians presents with unique clinical features described as the “South Asian phenotype” that include younger age at onset
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Efficacy of GLP-1 Receptor Agonists on Weight Loss, BMI, and Waist Circumference for Patients With Obesity or Overweight: A Systematic Review, Meta-analysis, and Meta-regression of 47 Randomized Controlled Trials Diabetes Care (IF 14.8) Pub Date : 2025-01-22 Hon Jen Wong, Bryan Sim, Yao Hao Teo, Yao Neng Teo, Mark Y. Chan, Leonard L.L. Yeo, Pei Chia Eng, Benjamin Y.Q. Tan, Naveed Sattar, Mayank Dalakoti, Ching-Hui Sia
OBJECTIVE To provide an updated synthesis on effects of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) on weight, BMI, and waist circumference incorporating newer randomized controlled trials (RCTs), particularly in individuals with overweight or obesity. RESEARCH DESIGN AND METHODS We systematically searched PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) for RCTs
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Derivation and Validation of D-RISK: An Electronic Health Record–Driven Risk Score to Detect Undiagnosed Dysglycemia in Clinical Practice Diabetes Care (IF 14.8) Pub Date : 2025-01-17 Michael E. Bowen, Ildiko Lingvay, Luigi Meneghini, Brett Moran, Noel O. Santini, Song Zhang, Ethan A. Halm
OBJECTIVE We derive and validate D-RISK, an electronic health record (EHR)-driven risk score to optimize and facilitate screening for undiagnosed dysglycemia (prediabetes + diabetes) in clinical practice. RESEARCH DESIGN AND METHODS We used retrospective EHR data (derivation sample) and a prospective diabetes screening study (validation sample) to develop D-RISK. Logistic regression with backward selection
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Financial Incentives, Income Supplementation, Cash Transfer, and Universal Basic Income Interventions in Diabetes: Understanding Differences and Effectiveness: A Scoping Review Diabetes Care (IF 14.8) Pub Date : 2025-01-14 Leonard E. Egede, Jennifer A. Campbell, Sebastian Linde, Rebekah J. Walker
The objective of this review is to evaluate and summarize the evidence base for the effects of monetary intervention approaches (the use of positive monetary reinforcers and gains) on diabetes outcomes. A reproducible search using OVID Medline, PubMed, Scopus, and CINAHL was conducted. Articles published from database creation up to July 2024 were searched. Outcomes included hemoglobin A1c (HbA1c)
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Three-Year Follow-up After Antiviral Treatment in New-Onset Type 1 Diabetes: Results From the Diabetes Virus Detection and Intervention Trial Diabetes Care (IF 14.8) Pub Date : 2025-01-13 Ida M. Mynarek, Lars Krogvold, Freja B. Mørk, Trine W. H. Lawaetz, Trine Roald, Morten W. Fagerland, Nina Lindblom, Jacob Westman, Peter Barker, Heikki Hyöty, Johnny Ludvigsson, Kristian F. Hanssen, Jesper Johannesen, Knut Dahl-Jørgensen
OBJECTIVE In the Diabetes Virus Detection and Intervention trial, antiviral treatment with pleconaril and ribavirin decreased the decline, compared with placebo, in endogenous C-peptide 1 year after diagnosis of type 1 diabetes (T1D) in children and adolescents. This article reports the results 2 and 3 years after diagnosis. RESEARCH DESIGN AND METHODS This was a multicenter, randomized, placebo-controlled
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Subtypes of Gestational Diabetes Mellitus Are Differentially Associated With Newborn and Childhood Metabolic Outcomes Diabetes Care (IF 14.8) Pub Date : 2025-01-09 Meredith E. Osmulski, Yuanzhi Yu, Alan Kuang, Jami L. Josefson, Marie-France Hivert, Denise M. Scholtens, William L. Lowe
OBJECTIVE Subtypes of gestational diabetes mellitus (GDM) based on insulin sensitivity and secretion have been described. We addressed the hypothesis that GDM subtypes are differentially associated with newborn and child anthropometric and glycemic outcomes. RESEARCH DESIGN AND METHODS Newborn and child (age 11–14 years) outcomes were examined in 7,970 and 4,160 mother-offspring dyads, respectively
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Glucagon-Like Peptide 1 Receptor Agonists and Sodium–Glucose Cotransporter 2 Inhibitors and the Prevention of Cirrhosis Among Patients With Type 2 Diabetes Diabetes Care (IF 14.8) Pub Date : 2025-01-08 Richeek Pradhan, Hui Yin, Sally Lu, Giada Sebastiani, Oriana Yu, Samy Suissa, Laurent Azoulay
OBJECTIVE To determine whether glucagon-like peptide 1 receptor agonists (GLP-1RAs) and sodium–glucose cotransporter 2 (SGLT-2) inhibitors, separately, compared with dipeptidyl peptidase 4 (DPP-4) inhibitors are associated with a reduced risk of cirrhosis and other adverse liver outcomes among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS With an active comparator, new-user approach, we
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Diabetes, Subclinical Myocardial Injury or Stress and Risk of Heart Failure Subtypes: The Jackson Heart Study Diabetes Care (IF 14.8) Pub Date : 2025-01-06 Arnaud D. Kaze, Alain G. Bertoni, Ervin R. Fox, Michael E. Hall, Robert J. Mentz, Jarett D. Berry, Justin B. Echouffo-Tcheugui
OBJECTIVE To assess the extent to which the concomitant presence of subclinical myocardial injury or stress and diabetes affects the risk of heart failure (HF) subtypes. RESEARCH DESIGN AND METHODS The Jackson Heart Study included Black adults, categorized based on diabetes status, high-sensitivity cardiac troponin I (hs-cTnI), and brain natriuretic peptide (BNP) levels. Subclinical myocardial injury
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Plasma Lipid Metabolites, Clinical Glycemic Predictors, and Incident Type 2 Diabetes Diabetes Care (IF 14.8) Pub Date : 2025-01-06 Arjana Begzati, Karla P. Godinez-Macias, Tao Long, Jeramie D. Watrous, Rafael Moranchel, Edward D. Kantz, Jaakko Tuomilehto, Aki S. Havulinna, Teemu J. Niiranen, Pekka Jousilahti, Veikko Salomaa, Bing Yu, Faye Norby, Casey M. Rebholz, Elizabeth Selvin, Elizabeth A. Winzeler, Susan Cheng, Mona Alotaibi, Ravi Goyal, Trey Ideker, Mohit Jain, Amit R. Majithia
OBJECTIVE Plasma metabolite profiling has uncovered several nonglycemic markers of incident type 2 diabetes (T2D). We investigated whether such biomarkers provide information about specific aspects of T2D etiology, such as impaired fasting glucose and impaired glucose tolerance, and whether their association with T2D risk varies by race. RESEARCH DESIGN AND METHODS Untargeted plasma metabolite profiling
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Incidence and Risk Factors of Diagnosed Young-Adult-Onset Type 2 Diabetes in the U.S.: The National Health Interview Survey 2016–2022 Diabetes Care (IF 14.8) Pub Date : 2025-01-03 Lan Xu, Jinjun Ran, Hui Shao, Meng Chen, Hao Tang, Yongxuan Li, Yaqing Xu, Yue Huang, Feng Tao, Zhenxiu Liu, Victor W. Zhong
OBJECTIVE To estimate the incidence and identify risk factors for diagnosed type 2 diabetes (T2D) among young U.S. adults. RESEARCH DESIGN AND METHODS We analyzed 142,884 adults aged 18–79 years with self-reported diabetes type from the cross-sectional National Health Interview Survey in 2016–2022, representing the noninstitutionalized U.S. civilian population. Incidence of diagnosed T2D was calculated
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Large-Scale Plasma Proteomics Improves Prediction of Peripheral Artery Disease in Individuals With Type 2 Diabetes: A Prospective Cohort Study Diabetes Care (IF 14.8) Pub Date : 2025-01-03 Hancheng Yu, Jijuan Zhang, Frank Qian, Pang Yao, Kun Xu, Ping Wu, Rui Li, Zixin Qiu, Ruyi Li, Kai Zhu, Lin Li, Tingting Geng, Xuefeng Yu, Danpei Li, Yunfei Liao, An Pan, Gang Liu
OBJECTIVE Peripheral artery disease (PAD) is a significant complication of type 2 diabetes (T2D), yet the association between plasma proteomics and PAD in people with T2D remains unclear. We aimed to explore the relationship between plasma proteomics and PAD in individuals with T2D, and assess whether proteomics could refine PAD risk prediction. RESEARCH DESIGN AND METHODS This cohort study included
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Proteomic and Metabolomic Signatures in Prediabetes Progressing to Diabetes or Reversing to Normoglycemia Within 1 Year Diabetes Care (IF 14.8) Pub Date : 2025-01-02 Marko Barovic, Joke Johanna Hahn, Annett Heinrich, Trishla Adhikari, Peter Schwarz, Peter Mirtschink, Alexander Funk, Stefan Kabisch, Andreas F.H. Pfeiffer, Matthias Blüher, Jochen Seissler, Norbert Stefan, Robert Wagner, Andreas Fritsche, Reiner Jumpertz von Schwartzenberg, Sarantis Chlamydas, Hani Harb, Christos S. Mantzoros, Triantafyllos Chavakis, Annette Schürmann, Andreas L. Birkenfeld, Michael
OBJECTIVE Progression of prediabetes to type 2 diabetes has been associated with β-cell dysfunction, whereas its remission to normoglycemia has been related to improvement of insulin sensitivity. To understand the mechanisms and identify potential biomarkers related to prediabetes trajectories, we compared the proteomics and metabolomics profile of people with prediabetes progressing to diabetes or
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The Association Between Cost-Related Insulin Rationing and Health Care Utilization in U.S. Adults With Diabetes Diabetes Care (IF 14.8) Pub Date : 2025-01-02 Caroline G. Borden, Baylee F. Bakkila, Laura M. Nally, Kasia J. Lipska
OBJECTIVE To examine the association between insulin rationing and health care utilization. RESEARCH DESIGN AND METHODS Cross-sectional study of all 2021 National Health Interview Survey respondents with diabetes using insulin. Logistic regression and zero-inflated negative binomial regression models examined associations between insulin rationing (skipping, delaying, or reducing insulin to save money)
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Tirzepatide Associated With Reduced Albuminuria in Participants With Type 2 Diabetes: Pooled Post Hoc Analysis From the Randomized Active- and Placebo-Controlled SURPASS-1–5 Clinical Trials Diabetes Care (IF 14.8) Pub Date : 2025-01-02 Ellen M. Apperloo, Katherine R. Tuttle, Imre Pavo, Axel Haupt, Rebecca Taylor, Russell J. Wiese, Andrea Hemmingway, David Z. I. Cherney, Naveed Sattar, Hiddo J. L. Heerspink
OBJECTIVE Tirzepatide, a long-acting, glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist, reduced urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) decline in people with type 2 diabetes and high cardiovascular risk in the SURPASS-4 trial. To examine the generalizability of these findings, we assessed change from baseline in
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Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study Diabetes Care (IF 14.8) Pub Date : 2025-01-02 Harshal Deshmukh, Emma G. Wilmot, Pratik Choudhary, Emmanuel Ssemmondo, Dennis Barnes, Neil Walker, Chris Walton, Robert E.J. Ryder, Thozhukat Sathyapalan
OBJECTIVE This study aimed to explore the relationship between time below range (TBR), impaired awareness of hypoglycemia (IAH), and severe hypoglycemia (SH). RESEARCH DESIGN AND METHODS This cross-sectional study analyzed data from individuals with diabetes using continuous glucose monitors (CGMs) in the Association of British Clinical Diabetologists audit. Hypoglycemia awareness was assessed via
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Prevalence of Diagnosed Diabetes Among U.S. Adults Aged ≥18 Years With Disabilities, 2021–2022 Diabetes Care (IF 14.8) Pub Date : 2025-01-02 Barbara H. Bardenheier, John D. Omura, Jinan B. Saaddine, Israel Hora, Kai McKeever Bullard
OBJECTIVE To compare the prevalence of diagnosed diabetes among U.S. adults with and without disabilities, overall and by subgroups. RESEARCH DESIGN AND METHODS We used data on adults aged ≥18 years from the cross-sectional 2021–2022 National Health Interview Survey to report the prevalence of diagnosed diabetes by functional disability status and for each disability type (hearing, seeing, mobility
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Prescribing Trends of Antidiabetes Medications Near End-of-Life Among Adults With Type 2 Diabetes: A Cohort Study Diabetes Care (IF 14.8) Pub Date : 2025-01-02 Alexander Kutz, Dae Hyun Kim, Jun Liu, Medha N. Munshi, Elisabetta Patorno
OBJECTIVE To assess prescribing trends of antidiabetes medications in the last year of life among older adults with type 2 diabetes (T2D) and explore whether frailty is associated with differential prescribing. RESEARCH DESIGN AND METHODS In this observational cohort study of Medicare beneficiaries aged ≥67 years (2015–2019) with T2D, we assessed temporal trends in prescribing an antidiabetes medication
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Cardiovascular Complications, Kidney Failure, and Mortality in Young-Onset Type 1 and 2 Diabetes: Data From the Korean National Health Insurance Service Diabetes Care (IF 14.8) Pub Date : 2024-12-23 Sung Eun Kim, Kyungdo Han, Won Kyoung Cho, Byung-Kyu Suh
OBJECTIVE To explore all-cause mortality and the incidence of cardiovascular and renal complications among patients with young-onset diabetes in South Korea using a nationwide registry database. RESEARCH DESIGN AND METHODS Data were collected from the Korean National Health Insurance Service–National Sample Cohort database from 2006 to 2019 for patients aged ≤30 years with type 1 (T1D) or 2 diabetes
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Glucose Abnormalities Detected by Continuous Glucose Monitoring in Very Old Adults With and Without Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-12-20 Natalie R. Daya, Michael Fang, Dan Wang, Arielle Valint, B. Gwen Windham, Josef Coresh, Justin B. Echouffo-Tcheugui, Elizabeth Selvin
OBJECTIVE To characterize the prevalence of continuous glucose monitoring (CGM)-defined glucose abnormalities in a large, community-based population of very old adults (>75 years). RESEARCH DESIGN AND METHODS A cross-sectional analysis of 1,150 older adults with and without diabetes who attended the Atherosclerosis Risk in Communities Study (2021–2022). Diabetes was based on a self-reported diagnosis
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Limitations in Achieving Glycemic Targets From CGM Data and Persistence of Severe Hypoglycemia in Adults With Type 1 Diabetes Regardless of Insulin Delivery Method Diabetes Care (IF 14.8) Pub Date : 2024-12-19 Lori M. Laffel, Jennifer L. Sherr, Jingwen Liu, Wendy A. Wolf, Jeoffrey Bispham, Katherine S. Chapman, Daniel Finan, Lina Titievsky, Tina Liu, Kaitlin Hagan, Jason Gaglia, Keval Chandarana, Jeremy Pettus, Richard Bergenstal
OBJECTIVE We captured continuous glucose monitoring (CGM) metrics from a large online survey of adults with type 1 diabetes to determine how glycemic outcomes varied by insulin delivery form. RESEARCH DESIGN AND METHODS Adults with type 1 diabetes from the T1D Exchange Registry/online communities completed the survey and contributed retrospective CGM data for up to 1 year. Self-reported glycemic outcomes
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Glycemic Management and Individualized Diabetes Care in Dialysis-Dependent Kidney Failure Diabetes Care (IF 14.8) Pub Date : 2024-12-18 Klara R. Klein, Ildiko Lingvay, Katherine R. Tuttle, Jennifer E. Flythe
Of the nearly 600,000 people in the U.S. who receive dialysis for chronic kidney failure, >60% have diabetes. People receiving dialysis who have diabetes have worse overall and cardiovascular survival rates than those without diabetes. Diabetes care in the dialysis setting is complicated by kidney failure–related factors that render extrapolation of glycated hemoglobin (HbA1c) targets to the dialysis
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Effect of Community-Based Integrated Care for Patients With Diabetes and Depression (CIC-PDD) in China: A Pragmatic Cluster-Randomized Trial Diabetes Care (IF 14.8) Pub Date : 2024-12-16 Yanshang Wang, Dan Guo, Yiqi Xia, Mingzheng Hu, Ming Wang, Qianqian Yu, Zhansheng Li, Xiaoyi Zhang, Ruoxi Ding, Miaomiao Zhao, Zhenyu Shi, Dawei Zhu, Ping He
OBJECTIVE To develop a care model for patients with both diabetes and depression and assess the model’s effectiveness. RESEARCH DESIGN AND METHODS In this pragmatic cluster randomized trial, we allocated eight community health centers into two groups: the enhanced usual care group and the intervention group. A comprehensive care plan was developed for the intervention group based on the integrated
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Risk of Nephrolithiasis Associated With SGLT2 Inhibitors Versus DPP4 Inhibitors Among Patients With Type 2 Diabetes: A Target Trial Emulation Study Diabetes Care (IF 14.8) Pub Date : 2024-12-12 Anna Shin, Ju-Young Shin, Eun Ha Kang
OBJECTIVE We aim to compare the risk of nephrolithiasis among type 2 diabetes patients who initiated sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus dipeptidyl-peptidase-4 inhibitors (DPP4is), individually within stone never- and ever-formers. RESEARCH DESIGN AND METHODS Using the 2010–2021 Korea National Health Insurance Service database, we conducted a population-based cohort study, comparing
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Use of SGLT2i Versus DPP-4i as an Add-On Therapy and the Risk of PAD-Related Surgical Events (Amputation, Stent Placement, or Vascular Surgery): A Cohort Study in Veterans With Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-12-09 Katherine E. Griffin, Kathryn Snyder, Amir H. Javid, Amber Hackstadt, Robert Greevy, Carlos G. Grijalva, Christianne L. Roumie
OBJECTIVE To compare the risk of composite peripheral artery disease (PAD) surgical outcome, including peripheral revascularization and amputation procedures, between new users of sodium–glucose cotransporter 2 inhibitors (SGLT2is) and dipeptidyl peptidase 4 inhibitors (DPP-4is). RESEARCH DESIGN AND METHODS This retrospective cohort study of U.S. veterans age ≥18 years with diabetes who received care
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Metformin Treatment With or Without Mediterranean Diet for the Prevention of Age-Related Diseases in People With Metabolic Syndrome: The MeMeMe Randomized Trial Diabetes Care (IF 14.8) Pub Date : 2024-12-06 Patrizia Pasanisi, Andreina Oliverio, Ivan Baldassari, Eleonora Bruno, Elisabetta Venturelli, Manuela Bellegotti, Giuliana Gargano, Daniele Morelli, Antonio Bognanni, Marta Rigoni, Paola Muti, Franco Berrino
OBJECTIVE The Metformin and Dietary Restriction to Prevent Age-Related Morbid Events in People With Metabolic Syndrome (MeMeMe) trial tested whether 1,700 mg/day metformin (MET) with or without a Mediterranean diet (MedDiet) intervention could reduce the cumulative incidence of major noncommunicable diseases in people with metabolic syndrome. RESEARCH DESIGN AND METHODS A total of 1,442 participants
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Diabetes Body Project: Acute Effects of an Eating Disorder Prevention Program for Young Women With Type 1 Diabetes. A Multinational Randomized Controlled Trial Diabetes Care (IF 14.8) Pub Date : 2024-12-04 Mareille H.C.L. Hennekes, Severina Haugvik, Maartje de Wit, Elena Toschi, Christopher D. Desjardins, Torild Skrivarhaug, Knut Dahl-Jørgensen, Eric Stice, Line Wisting
OBJECTIVE Young women with type 1 diabetes are at risk to develop eating disorders (ED). We evaluated a novel ED prevention program in a multinational randomized controlled trial. RESEARCH DESIGN AND METHODS Women (14–35 years old) with type 1 diabetes were randomized to virtual Diabetes Body Project groups or educational control. Outcomes were assessed at pretest and posttest (1–2 weeks after intervention)
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Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes Diabetes Care (IF 14.8) Pub Date : 2024-12-03 Carolyn McGrail, Joshua Chiou, Ruth Egamal, Amber M. Luckett, Richard A. Oram, Paola Benaglio, Kyle J. Gaulton
OBJECTIVE More than 10% of patients with type 1 diabetes (T1D) do not have high-risk HLA-DR3 or -DR4 haplotypes with distinct clinical features, such as later onset and reduced insulin dependence. We aimed to identify genetic drivers of T1D in the absence of DR3/DR4 and improve prediction of T1D risk in these individuals. RESEARCH DESIGN AND METHODS We performed T1D association and fine-mapping analyses
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Continuous Glucose Monitor Accuracy for Diabetes Management in Hospitalized Children Diabetes Care (IF 14.8) Pub Date : 2024-12-02 Neha Garg, Kamryn Lewis, Perrin C. White, Soumya Adhikari
OBJECTIVE The adoption of continuous glucose monitors (CGMs) in inpatient settings in the pediatric population has been slow because of a scarcity of data on their reliability in hospitalized children. RESEARCH DESIGN AND METHODS We retrospectively reviewed the accuracy of the Dexcom G6 CGM system in pediatric patients with diabetes admitted to our academic children’s hospital from March 2018 to September
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Compounded GLP 1 and Dual GIP/GLP 1 Receptor Agonists: A Statement from the American Diabetes Association Diabetes Care (IF 14.8) Pub Date : 2024-12-02 Joshua J. Neumiller, Mandeep Bajaj, Raveendhara R. Bannuru, Rozalina G. McCoy, Elizabeth J. Pekas, Alissa R. Segal, Nuha A. ElSayed
The use of glucagon-like peptide 1 receptor agonist (GLP-1 RA) and dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 RA (GIP/GLP-1 RA) classes has increased substantially over the past several years for treating type 2 diabetes and obesity. Increased demand for these pharmacotherapies has resulted in temporary product shortages for both GLP-1 RA and dual GIP/GLP-1 RA medications. These
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A Systematic Review and Meta-analysis on the Safety and Efficacy of Sodium–Glucose Cotransporter 2 Inhibitor Use in Hospitalized Patients Diabetes Care (IF 14.8) Pub Date : 2024-11-27 Frank M. Gao, Aleena S. Ali, Rinaldo Bellomo, Michele Gaca, Ashani Lecamwasam, Leonid Churilov, Elif I. Ekinci
BACKGROUND The safety and efficacy of sodium–glucose cotransporter 2 (SGLT2) inhibitors in hospitalized patients are unclear. PURPOSE To evaluate outcomes of inpatient SGLT2 inhibitor use. DATA SOURCES MEDLINE, Embase, Emcare, and Cochrane databases were searched through 29 May 2024. STUDY SELECTION Randomized controlled trials (RCTs) and observational cohort studies with assessment of SGLT2 inhibitor
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Effects of Integrated Care Approaches to Address Co-occurring Depression and Diabetes: A Systematic Review and Meta-analysis Diabetes Care (IF 14.8) Pub Date : 2024-11-27 Zach W. Cooper, Jay O’Shields, Mohammed K. Ali, Lydia Chwastiak, Leslie C.M. Johnson
BACKGROUND Depressive symptoms frequently co-occur with diabetes and, when unaddressed, can function to worsen diabetes control and increase the risk of diabetes-related morbidity. Integrated care (IC) approaches aim to improve outcomes among people with diabetes and depression, but there are no current meta-analyses examining their effects. PURPOSE In our study we summarize the effects of IC approaches
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Cutaneous Carbonyl Stress Is Associated With Nerve Dysfunction in Recent-Onset Type 2 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-11-25 Gidon J. Bönhof, Alexander Strom, Tobias Jung, Kálmán B. Bódis, Julia Szendroedi, Robert Wagner, Tilman Grune, Michael Roden, Dan Ziegler
OBJECTIVE Endogenous carbonyl stress leads to the formation of advanced glycation end products (AGEs). AGEs represent a potential target to prevent or treat diabetic sensorimotor polyneuropathy (DSPN). The current study aimed to characterize cutaneous carbonyl stress, oxidative stress, immune cells, and endothelial cell damage in early type 2 diabetes compared with normal glucose tolerance (NGT) using
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Osteoprotegerin, Osteopontin, and Osteocalcin Are Associated With Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL Diabetes Care (IF 14.8) Pub Date : 2024-11-22 Ernesto Maddaloni, Maggie Nguyen, Svati H. Shah, Rury R. Holman
OBJECTIVE To evaluate the association of four bone metabolism biomarkers (osteoprotegerin, osteopontin, sclerostin, and osteocalcin) with cardiovascular events in people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS The Exenatide Study of Cardiovascular Event Lowering (EXSCEL) was a randomized clinical trial evaluating the cardiovascular (CV) safety and efficacy of once-weekly exenatide for
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Association of Insulin Resistance With Radiographic Lung Abnormalities and Incident Lung Disease: The Framingham Offspring Study Diabetes Care (IF 14.8) Pub Date : 2024-11-21 Sarath Raju, Paula Sierra, Vickram Tejwani, Kristen A. Staggers, Meredith McCormack, Dennis T. Villareal, Ivan O. Rosas, Nicola A. Hanania, Tianshi David Wu
OBJECTIVE Insulin resistance (IR) may be a risk factor for lung disease, but objective evidence is limited. We sought to define the relationship of longitudinal IR with radiographic imaging outcomes and examiner-identified incident lung disease in the Framingham Offspring Study. RESEARCH DESIGN AND METHODS Participants without baseline lung disease underwent repeated measurements of fasting insulin
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Burden and Excess Risk of Adverse Outcomes in Patients With Type 1 Diabetes Using KDIGO Classification: A National Cohort Study Diabetes Care (IF 14.8) Pub Date : 2024-11-20 Kianoush Makvandi, Björn Eliasson, Hanne Krage Carlsen, Seema Baid-Agrawal
OBJECTIVE The widely adopted Kidney Disease: Improving Global Outcomes (KDIGO) classification system has been underused in assessing the burden and risk of adverse outcomes in type 1 diabetes. This observational study aimed to clarify how each KDIGO category correlates with outcomes, including mortality, in this patient group. RESEARCH DESIGN AND METHODS In 40,199 individuals with type 1 diabetes from
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Reduced Aqueous Retinol-Binding Protein 3 Concentration Is Associated With Diabetic Macular Edema and Progression of Diabetic Retinopathy Diabetes Care (IF 14.8) Pub Date : 2024-11-20 Tanvi Chokshi, Ward Fickweiler, Surya Jangolla, Kyoungmin Park, I-Hsien Wu, Hetal Shah, Jennifer K. Sun, Lloyd Paul Aiello, George L. King
OBJECTIVE To evaluate the association of aqueous retinol-binding protein 3 (RBP3) with history of diabetic macular edema (DME) and diabetic retinopathy (DR) progression. RESEARCH DESIGN AND METHODS RBP3 concentration was measured by ELISA in aqueous from patients undergoing cataract surgery at Joslin Diabetes Center. DR progression was defined as two-step or more worsening on the Early Treatment Diabetic
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Cost-Effectiveness of the National Diabetes Prevention Program: A Real-World, 2-Year Prospective Study Diabetes Care (IF 14.8) Pub Date : 2024-11-20 Shihchen Kuo, Wen Ye, Di Wang, Laura N. McEwen, Claudia Villatoro Santos, William H. Herman
OBJECTIVE We evaluated the real-world cost-effectiveness of the National Diabetes Prevention Program (NDPP) for people with prediabetes in a large workforce with employer-sponsored health insurance. RESEARCH DESIGN AND METHODS We performed difference-in-differences analyses using individual-level health insurance claims and survey data for 5,948 adults with prediabetes who enrolled (n = 575) or did
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Trends in Peripheral Artery Disease, Lower Extremity Revascularization, and Lower Extremity Amputation in Incident Type 2 Diabetes: A Danish Population-Based Cohort Study Diabetes Care (IF 14.8) Pub Date : 2024-11-15 Christine Gyldenkerne, Kevin K.W. Olesen, Pernille G. Thrane, Malene K. Hansen, Nina Stødkilde-Jørgensen, Henrik T. Sørensen, Reimar W. Thomsen, Michael Maeng
OBJECTIVE To examine trends in peripheral artery disease (PAD), lower-extremity (LE) revascularization, and LE amputation in patients with incident type 2 diabetes. RESEARCH DESIGN AND METHODS This cohort study included patients in Denmark diagnosed with type 2 diabetes in 1996–2015 and followed until 2020. Patients were age and sex matched with as many as three general population individuals. Outcomes
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Using Time in Tight Glucose Range as a Health-Promoting Strategy in Preschoolers With Type 1 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-11-15 Frida Sundberg, Carmel E. Smart, John Samuelsson, Karin Åkesson, Lars Krogvold
Children who develop diabetes in their first years of life risk being exposed to many decades of hyperglycemia, hence having a high risk of early complications and premature death. An additional age-dependent risk is that dysglycemia, especially hyperglycemia, negatively affects the developing brain. In evaluating the outcome of insulin treatment at an individual and group level, cutoff thresholds
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Interoceptive Awareness Is Associated With Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes Diabetes Care (IF 14.8) Pub Date : 2024-11-15 Austin M. Matus, Barbara Riegel, Michael R. Rickels
OBJECTIVE To assess the association between impaired awareness of hypoglycemia (IAH) and interoceptive awareness in type 1 diabetes. RESEARCH DESIGN AND METHODS A total of 154 adults with type 1 diabetes completed IAH surveys and the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2). Logistic regression was performed for assessment of associations between IAH and MAIA-2, accounting
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Life Course Associations Between Ambient Fine Particulate Matter and the Prevalence of Prediabetes and Diabetes: A Longitudinal Cohort Study in Taiwan and Hong Kong Diabetes Care (IF 14.8) Pub Date : 2024-11-12 Yuanyuan Yi, Cui Guo, Yiling Zheng, Siyi Chen, Changqing Lin, Alexis K. H. Lau, Martin C. S. Wong, David M. Bishai
OBJECTIVE Both air pollution and diabetes are key urban challenges. The association between particulate matter with a diameter of <2.5 μm (PM2.5) exposure and prediabetes/diabetes in adults is well documented, but the health effects of life course exposure remain unclear. This study evaluated the impact of PM2.5 exposure throughout various life stages on the prevalence of prediabetes/diabetes in adulthood