Representative images of cFos and 53BP1 immunoreactive cells in the CA1 region of the hippocampus from a young female apolipoprotein E4 (apoE) targeted replacement mouse 1.5 h after fear conditioning. Images were taken of young (3 month) and middle-aged (12 months) male and female mice that were never exposed to fear conditioning (behaviorally naïve), euthanized 1.5 h after fear conditioning, or euthanized

Chronic pain is a prevalent neurological complication among individuals living with human immunodeficiency virus (PLHIV) in the post-combination antiretroviral therapy (cART) era. These individuals experience malfunction in various cellular and molecular pathways involved in pain transmission and modulation, including the neuropathology of the peripheral sensory neurons and neurodegeneration and neuroinflammation

ADNP localization in neuronal stem cells grown as neurospheres by immunofluorescence staining. Top: low magnification, Scale bar = 1 mm. Low: high magnification. Scale bar = 25 μm. For more information, please refer to the article by Bennison et al., in this issue.

Psychedelic therapy (PT) is an emerging paradigm with great transdiagnostic potential for treating psychiatric disorders, including depression, addiction, post-traumatic stress disorder, and potentially others. ‘Classic’ serotonergic psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), which have a key locus of action at the 5-HT2A receptor, form the main focus of this movement, but