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The Use of Blood-Based Proteomic Biomarkers for the Diagnosis of Sports-Related Concussion. Neurology (IF 7.7) Pub Date : 2025-02-07 Daniel Whitehouse,Virginia Newcombe
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Association of Rheumatoid Arthritis With Progression of Cognitive Impairment and Risk of Mortality in People With Dementia. Neurology (IF 7.7) Pub Date : 2025-02-07 Minjia Mo,Maria Eriksdotter,Sofia Ajeganova,Sumonto Mitra,Sara Garcia-Ptacek,Hong Xu
BACKGROUND AND OBJECTIVES Rheumatoid arthritis (RA) has been linked to an increased risk of dementia, yet little is known about how RA affects the progression of cognitive impairment and the risk of mortality in people with dementia. We aimed to investigate whether RA is linked to an accelerated cognitive decline and a higher risk of all-cause mortality in patients with dementia. METHODS We conducted
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Disease Burden in Female Patients With X-Linked Adrenoleukodystrophy. Neurology (IF 7.7) Pub Date : 2025-02-07 Natalie R Grant,Yedda Li,Lizbeth De La Rosa Abreu,Catherine Becker,Brian D Wishart,Amanda Nagy,Florian S Eichler,Reza Sadjadi
BACKGROUND AND OBJECTIVES X-linked adrenoleukodystrophy (ALD) is a neurodegenerative disease primarily affecting male patients. Female patients with ALD are also affected in adulthood, yet their disease course and symptom burden remain poorly defined. In this single-site study, we set out to characterize disease burden in female individuals with ALD and identify barriers faced by this patient population
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Teaching Video NeuroImage: Unraveling the Enigma of Ocular Flutter in Anti-GD1b and Anti-GT1a Rhombencephalitis. Neurology (IF 7.7) Pub Date : 2025-02-06 Yao Qin,Zhihong Xu,Xingyu Zhuang,Kunqian Ji
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Optimal Magnitude of Blood Pressure Reduction and Hematoma Growth and Functional Outcomes in Intracerebral Hemorrhage. Neurology (IF 7.7) Pub Date : 2025-02-06 Qi Li,Xinni Lv,Andrea Morotti,Adnan I Qureshi,Dar Dowlatshahi,Guido J Falcone,Kevin Navin Sheth,Ashkan Shoamanesh,Santosh B Murthy,Anand Viswanathan,Joshua N Goldstein
BACKGROUND AND OBJECTIVES Early intensive systolic blood pressure (SBP) reduction is a promising strategy for intracerebral hemorrhage (ICH), but the optimal magnitude of reduction in the first 2 hours remains uncertain. This study aimed to determine the optimal SBP reduction magnitude to maximize benefit in patients enrolled in the Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 (ATACH-2)
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Severe Relapse After Switching From Eculizumab to Satralizumab in Neuromyelitis Optica Spectrum Disorder. Neurology (IF 7.7) Pub Date : 2025-02-06 Elisabeth Maillart,Anne-Laure Dubessy,Natalia Shor,Mathilde Piljan,Rene Decombe,Catherine Lubetzki,Bruno Stankoff,Romain Marignier,Ysoline Beigneux
OBJECTIVES Several treatments have been approved for the prevention of attacks in AQP4-IgG+ neuromyelitis optica spectrum disorder (NMOSD). However, because of the rarity of the disease, little is known concerning how to switch from one treatment to another in case of lack of effectiveness or side effects. In this article, we report a severe attack in a patient with NMOSD after switching from eculizumab
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Rapid Evolution of an Iatrogenic Cerebral Amyloid Angiopathy. Neurology (IF 7.7) Pub Date : 2025-02-06 Thomas Courret,Megane Le Quang,Pauline Renou,Guillaume Penchet,Thomas Tourdias
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Clinical Reasoning: A 68-Year-Old Man With Progressive Numbness, Vertigo, and Cognitive Decline. Neurology (IF 7.7) Pub Date : 2025-02-06 Stephanie Marie Regan,Long F Davalos
A 68-year-old man presented with subacute progressive numbness in his lower extremities and vertigo. Concurrently, he developed behavioral and cognitive changes. Initial examination demonstrated mild distal symmetric weakness in the lower extremities, allodynia in the feet, decreased proprioception at the ankles, and absent reflexes in the lower extremities. Electrodiagnostic studies showed a length-dependent
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Perspectives Toward the Development of Quantitative Seed Amplification Assays for α-Synuclein. Neurology (IF 7.7) Pub Date : 2025-02-06 Simone Baiardi,Piero Parchi
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α-Synuclein Seed Amplification Assay Amplification Parameters and the Risk of Progression in Prodromal Parkinson Disease. Neurology (IF 7.7) Pub Date : 2025-02-06 David G Coughlin,Ben Shifflett,Carly M Farris,Yihua Ma,Douglas Galasko,Steven D Edland,Brit Mollenhauer,Michael C Brumm,Kathleen L Poston,Kenneth Marek,Andrew D Siderowf,Claudio Soto,Luis Concha-Marambio,
OBJECTIVES Tools are needed to evaluate the risk of developing Parkinson disease (PD) in at-risk populations. In this study, we examine differences in alpha-synuclein seed amplification assay (αSyn-SAA) qualitative results and amplification parameters between nonmanifesting carriers (NMCs) of PD-related pathogenic variants, prodromal PD, and PD and the risk of developing a synucleinopathy in participants
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Influence of Risk Factor Combinations on Incidence Rates of SUDEP: A Population-Based Study. Neurology (IF 7.7) Pub Date : 2025-02-05 Torbjörn Tomson,Tomas Andersson,Sofia Carlsson,Olafur Sveinsson
BACKGROUND AND OBJECTIVE Information on absolute risks of sudden unexpected death in epilepsy (SUDEP) in individual patients with epilepsy is scarce. Our main objective was therefore to explore the range in incidence rates of SUDEP to provide a more solid basis for individualized counseling and to characterize patients with high and very high SUDEP incidence for future intervention studies aiming at
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Association of Race and Ethnicity With Emergency Room Rate of Migraine Diagnosis, Testing, and Management in Children With Headache. Neurology (IF 7.7) Pub Date : 2025-02-05 Danielle Kellier,Marissa Maliakal Anto,Matt Hall,Jennifer Marin,Kendall Nash,Elizabeth M Wells,Nicholas S Abend,Melissa L Hutchinson,Mahendranath Moharir,Ricka Denise Messer,Jamie Lee Palaganas,Juan Piantino,Christina Szperka,Craig Press,
BACKGROUND AND OBJECTIVES Headache evaluation and treatment are believed to be influenced by race and ethnicity. Specific headache diagnosis assigned in the pediatric emergency department (ED) may compound disparities. We sought to investigate racial and ethnic disparities in the diagnosis, testing, and treatment of pediatric patients with headache presenting to the ED. METHODS We performed a cross-sectional
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The Burden of Multiple Sclerosis in Mexico. Neurology (IF 7.7) Pub Date : 2025-02-05 Enrique Gómez-Figueroa,Carlos Javier Moreno-Bernardino,Andrea Margarita De Alba-Sánchez,Natali Guerrero-Udave,Patricia Orozco-Puga,Cynthia Patricia Corona-Vázquez,María Eugeni Briseño-Godínez,Omar Cárdenas-Sáenz,Amado Jímenez-Ruiz,Brenda Allison Verboonen-Salgado,Nayeli Sánchez-Rosales,Christian García Estrada,José Luis Ruíz-Sandoval
BACKGROUND AND OBJECTIVES Multiple sclerosis (MS) is a CNS disease causing significant disability, mainly in young and middle-aged individuals. Despite extensive global research, Mexico lacks comprehensive epidemiologic data on MS, complicating effective health care planning and intervention. This study analyzes the epidemiology of MS in Mexico using data from the Global Burden of Disease (GBD) study
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Author Response: Functional Outcome and Hemorrhage Rates After Bridging Therapy With Tenecteplase or Alteplase in Patients With Large Ischemic Core. Neurology (IF 7.7) Pub Date : 2025-02-05 Gaspard Gerschenfeld,Sonia Alamowitch
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Reader Response: Functional Outcome and Hemorrhage Rates After Bridging Therapy With Tenecteplase or Alteplase in Patients With Large Ischemic Core. Neurology (IF 7.7) Pub Date : 2025-02-05 Qian Feng
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Age-Related Disability Outcomes After a First Demyelinating Event. Neurology (IF 7.7) Pub Date : 2025-02-04 Alvaro Cobo-Calvo,Pere Carbonell-Mirabent,Carmen Tur,Susana Otero-Romero,Rene Carvajal,Georgina Arrambide,Helena Ariño,Cristina Auger,Javier Villacieros-Álvarez,Luca Bollo,Joaquín Castilló,Manuel Comabella,Carmen Espejo,Victoria Fernández,Claudia Guio-Sánchez,Ingrid Galan,Delon La Puma,Luciana Soledad Midaglia,Neus Mongay-Ochoa,Andreu Vilaseca,Maria Jesus Arevalo Navines,Carlos Nos,Agustin Pappolla
BACKGROUND AND OBJECTIVES Emerging concepts in the early detection of multiple sclerosis (MS) progression reveal that disability accumulation can start early in the disease course. Aging in MS is increasingly recognized as a key factor for disease progression and disability accrual. We evaluate the prognostic impact of age in a cohort of patients experiencing a first demyelinating event (FDE), using
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Age Matters in Multiple Sclerosis: Novel Insights Into Disease Progression From Clinical Onset. Neurology (IF 7.7) Pub Date : 2025-02-04 Maria A Rocca,Paolo Preziosa,Massimo Filippi
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Spatial and Temporal Distribution of White Matter Lesions in NOTCH2NLC-Related Neuronal Intranuclear Inclusion Disease. Neurology (IF 7.7) Pub Date : 2025-02-03 Shaoping Zhong,Beini Fei,Jingzhen Liang,Yangye Lian,Jing Wang,Ying Liu,Yuwen Zhang,Jianying Liu,Xin Wang,Jing Ding
BACKGROUND AND OBJECTIVES NOTCH2NLC-related neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease with characteristic white matter lesions (WMLs) visible on MRI. However, the distribution of WMLs and their clinical correlations remain poorly understood in NIID. This study aims to investigate the spatial and temporal distribution of WMLs in the brain of patients with NOTCH2NLC-related
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Distinguishing Description, Prediction, and Causal Inference: A Primer on Improving Congruence Between Research Questions and Methods. Neurology (IF 7.7) Pub Date : 2025-02-03 Chisato Ito,Linda Al-Hassany,Tobias Kurth,Toivo Glatz
This primer introduces the domains into which the aims of quantitative health research generally fall and provides tools to improve the methodological quality of observational clinical and population-based research articles-with a special focus on the field of neurology. Generally, research questions can be categorized into one of the following 3 data science domains: description, prediction, and causal
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Study of the Association Between Menarche and Disease Course in Pediatric Multiple Sclerosis. Neurology (IF 7.7) Pub Date : 2025-02-03 Kristen M Krysko,Michael Waltz,Tanuja Chitnis,Bianca Weinstock-Guttman,Gregory S Aaen,Anita Belman,Leslie A Benson,Mark P Gorman,Timothy E Lotze,Soe S Mar,Manikum Moodley,Jayne M Ness,Mary Rensel,Moses Rodriguez,John W Rose,Alice Rutatangwa Edwards,Teri L Schreiner,Yolanda S Wheeler,Bradley J Barney,Emmanuelle Waubant,T Charles Casper,Jennifer S Graves,
BACKGROUND AND OBJECTIVES Sex steroid hormones have been demonstrated to affect the immune system in multiple sclerosis (MS), and puberty may trigger MS activity. We aimed to evaluate the association between menarche and disease course in pediatric MS through comparison of relapse rates across premenarche, perimenarche, and postmenarche periods. METHODS This is a retrospective analysis of a prospectively
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Statistical Practice of Ordinal Outcome Analysis in Neurologic Trials: A Literature Review. Neurology (IF 7.7) Pub Date : 2025-02-03 Yongxi Long,Sophie C de Ruiter,Linda W G Luijten,Eveline J A Wiegers,Diederik W J Dippel,Pieter A Van Doorn,Bart C Jacobs,Ewout W Steyerberg
BACKGROUND AND OBJECTIVES Ordinal scales are widely adopted as outcome measures in neurologic randomized controlled trials (RCTs). We aimed to evaluate which statistical methods have been used to test and estimate treatment effects from ordinal outcomes in recent RCTs across a range of acute neurologic diseases. METHODS We searched PubMed for RCTs in 5 acute monophasic neurologic diseases (stroke,
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Use of Stacked Proportional Bar Graphs ("Grotta Bars") in Observational Neurology Research: A Meta-Research Study. Neurology (IF 7.7) Pub Date : 2025-02-03 Meghan R Forrest,Tracey L Weissgerber,Emma S Lieske,Elena Tamayo Cuartero,Elena Fischer,Lydia Jones,Marco Piccininni,Jessica L Rohmann
BACKGROUND AND OBJECTIVES Stacked proportional bar graphs (nicknamed "Grotta bars") are commonly used to visualize functional outcome scales in stroke research and are also used in other domains of neurology research. While lending themselves to a straightforward causal interpretation in ideal randomized controlled trials, in observational studies, Grotta bars cannot be generally interpreted causally
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Menarche and Relapses in Multiple Sclerosis: Associations Between a Physiologic Developmental Milestone and Disease Activity. Neurology (IF 7.7) Pub Date : 2025-02-03 J Nicholas Brenton
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Progression in the Understanding of Cerebral Small Vessel Disease Regression. Neurology (IF 7.7) Pub Date : 2025-02-03 Esther Janssen,Frank-Erik de Leeuw
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Longitudinal Cognitive Changes in Cerebral Small Vessel Disease: The Effect of White Matter Hyperintensity Regression and Progression. Neurology (IF 7.7) Pub Date : 2025-02-03 Angela C C Jochems,Susana Muñoz Maniega,Una Clancy,Carmen Arteaga-Reyes,Daniela Jaime Garcia,Francesca M Chappell,Olivia K L Hamilton,Ellen V Backhouse,Gayle Barclay,Charlotte Jardine,Donna McIntyre,Iona Hamilton,Eleni Sakka,Maria Del C Valdés Hernández,Stewart Wiseman,Mark E Bastin,Michael S Stringer,Michael Thrippleton,Fergus Doubal,Joanna M Wardlaw
BACKGROUND AND OBJECTIVES White matter hyperintensities (WMHs) are the commonest imaging marker of cerebral small vessel disease (SVD) and a major cause of cognitive decline and vascular dementia. WMHs typically accumulate over time, but recent studies show they can also regress, but potential clinical benefits have received little attention. We examined progressing, stable, and regressing WMH in people
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Cardiac Conduction Delay for Sodium Channel Antagonist Antiseizure Medications: An Analysis of the Canadian Longitudinal Study on Aging. Neurology (IF 7.7) Pub Date : 2025-02-03 Nathan A Shlobin,Jimmy Li,Josemir W Sander,Mark Robert Keezer,Roland D Thijs
BACKGROUND AND OBJECTIVES People with epilepsy are at risk of cardiac arrhythmias. Whether this association results from epilepsy, antiseizure medications (ASMs) such as sodium channel blockers (NABs), or other factors has not been systematically assessed. The aims of this study were to quantify the odds of cardiac conduction delays (CCDs) on electrocardiogram in older people with active epilepsy using
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Clinicopathological Description of Vasculitic Neuropathy by Minkowski (1888) and Joffroy and Achard (1889). Neurology (IF 7.7) Pub Date : 2025-02-03 Stephane Mathis,Jean-Michel Vallat
Since its introductory characterization by Kussmaul and Maier in 1866, the understanding of vasculitis has evolved significantly. Modern classification systems provide clear clinical and histopathologic definitions. Although early vasculitis cases likely included neuromuscular involvement, specific clinicopathologic descriptions of nerve vasculitis were lacking. We present early clinicopathologic descriptions
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Methodologic Considerations for Randomized Clinical Trials and Observational Studies to Guide Clinical Care. Neurology (IF 7.7) Pub Date : 2025-02-03 Holly Elser,Elizabeth Rose Mayeda,Andrea Lauren Christman Schneider
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Reader Response: A Preponderance of Evidence: A Call for a Randomized Trial in Posterior Circulation Stroke. Neurology (IF 7.7) Pub Date : 2025-01-31 Davide Strambo,Simon Nagel,Patrik Michel
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Pearls & Oy-sters: Isolated Acquired Amusia in a Patient With Right Temporal Stroke. Neurology (IF 7.7) Pub Date : 2025-01-31 Mark Dibbs,Jeremy J Moeller
Strokes in the right temporal lobe are known to cause acquired amusia, or deficits in music processing, which can be formally assessed using the online version of the Montreal Battery of Evaluation of Amusia (MBEA). Patients with acquired amusia most often present with not only amusia but also other neurologic symptoms, such as aphasia, neglect, or memory issues. We report a case of a 39-year-old man
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Teaching Video NeuroImage: Globe Retraction in Duane Syndrome. Neurology (IF 7.7) Pub Date : 2025-01-31 Ruben Jauregui,Scott N Grossman
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Clinical Reasoning: A 32-Year-Old Woman With Recurrent Intracerebral Hemorrhages. Neurology (IF 7.7) Pub Date : 2025-01-31 Mette Foldager Hindsholm,David Gaist,Benedicte Parm Ulhøi,Claus Ziegler Simonsen
Evaluating patients with intracerebral hemorrhage is common practice in the field of stroke neurology but can be complicated and may require extensive evaluation in younger patients with no history of hypertension. In this case, a healthy 32-year-old woman presented with an acute spontaneous lobar intracerebral hemorrhage. Neurologic workup required extensive imaging evaluation, genetic testing, and
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Editors' Note: A Preponderance of Evidence: A Call for a Randomized Trial in Posterior Circulation Stroke. Neurology (IF 7.7) Pub Date : 2025-01-31 Ariane Lewis,Steven L Galetta
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Right Brain: Of Puddles and Pinnacles: A Letter to My Fearless Little Girl. Neurology (IF 7.7) Pub Date : 2025-01-31 Erin D'Agostino,Christopher LaRocca
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What Is the Function and Relevance of 14-3-3 Proteins in Neurologic Disease? Neurology (IF 7.7) Pub Date : 2025-01-31 Eduardo Benarroch
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Association of Plasma Biomarkers of Alzheimer Disease and Neurodegeneration With Longitudinal Intra-Network Functional Brain Connectivity. Neurology (IF 7.7) Pub Date : 2025-01-31 Heather E Dark,Andrea T Shafer,Jenifer Cordon,Yang An,Alexandria Lewis,Abhay Moghekar,Bennett Landman,Susan M Resnick,Keenan A Walker
BACKGROUND AND OBJECTIVES Alzheimer disease (AD) is defined by cortical β-amyloid (Aβ), tau, and neurodegeneration, which contribute to cognitive decline, in part, by altering large-scale functional brain networks. While cortical Aβ and tau have been associated with changes in functional brain connectivity, it is unknown whether plasma biomarkers relate to such changes. In a healthy community sample
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Reconstructing Covert Consciousness: Neural Decoding as a Novel Consciousness Assessment. Neurology (IF 7.7) Pub Date : 2025-01-30 David Fischer,Brian L Edlow,Holly J Freeman,Daniel Alaiev,Qichao Wu,Jeffrey B Ware,John A Detre,Geoffrey K Aguirre
Determining the level of consciousness in patients with brain injury-and more fundamentally, establishing what they can experience-is ethically and clinically impactful. Patient behaviors may unreliably reflect their level of consciousness: a subset of unresponsive patients demonstrate covert consciousness by willfully modulating their brain activity to commands through fMRI or EEG. However, current
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Long-Term Treatment With Ocrelizumab in Patients With Early-Stage Relapsing MS: Nine-Year Data From the OPERA Studies Open-Label Extension. Neurology (IF 7.7) Pub Date : 2025-01-30 João J Cerqueira,Achim Berthele,Bruce A C Cree,Massimo Filippi,Gabriel Pardo,Owen R Pearson,Anthony Traboulsee,Tjalf Ziemssen,Timothy Vollmer,Corrado Bernasconi,Corey R Mandel,Inessa Kulyk,Cathy Chognot,Catarina Raposo,Hans-Martin Schneble,Gian-Andrea Thanei,Elodie Incera,Eva K Havrdová
BACKGROUND AND OBJECTIVES Patients with multiple sclerosis (MS) may demonstrate better disease control when treatment is initiated on high-efficacy disease-modifying therapies (DMTs) from onset. This subgroup analysis assessed the long-term efficacy and safety profile of the high-efficacy DMT ocrelizumab (OCR) as first-line therapy for early-stage relapsing MS (RMS). METHODS Post hoc exploratory analyses
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Characterization of Factors Associated With Death in Deceased Patients With Mitochondrial Disorders: A Multicenter Cross-Sectional Survey. Neurology (IF 7.7) Pub Date : 2025-01-30 Alina Ivaniuk,Irina A Anselm,Aaron Bowen,Bruce H Cohen,Fatma Tuba Eminoglu,Jane Estrella,Renata C Gallagher,Rebecca D Ganetzky,Jennifer Gannon,Grainne S Gorman,Carol Greene,Andrea L Gropman,Richard H Haas,Michio Hirano,Seema Kapoor,Amel Karaa,Mary Kay Koenig,Cornelia Kornblum,Engin Kose,Austin Larson,Uta Lichter-Konecki,Piervito Lopriore,Michelangelo Mancuso,Robert McFarland,Aye Myat Moe,Eva Morava
BACKGROUND AND OBJECTIVES Mitochondrial disorders are multiorgan disorders resulting in significant morbidity and mortality. We aimed to characterize death-associated factors in an international cohort of deceased individuals with mitochondrial disorders. METHODS This cross-sectional multicenter observational study used data provided by 26 mitochondrial disease centers from 8 countries from January
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Interpreting the Results of 9-Year Open-Label Extension of Ocrelizumab in Treatment-Naïve Patients With Relapsing MS. Neurology (IF 7.7) Pub Date : 2025-01-30 Olga Ciccarelli,Alan J Thompson
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Health Care Delivery and Financial Considerations in Amyotrophic Lateral Sclerosis Clinics: A Survey of Clinic Directors. Neurology (IF 7.7) Pub Date : 2025-01-30 Ilene L Hollin,Gema Giler,Terry D Heiman-Patterson,
BACKGROUND AND OBJECTIVES Clinical care for people living with amyotrophic lateral sclerosis (PLWALS) is directed at slowing disease progression and symptom management. The American Academy of Neurology recommends a multidisciplinary approach to providing ALS health care because observational studies show that multidisciplinary clinics (MDCs) extend survival and improve quality of life. However, providing
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The Amyotrophic Lateral Sclerosis Multidisciplinary Clinic: Broke but Not Broken. Neurology (IF 7.7) Pub Date : 2025-01-30 Christina N Fournier,Colin C Quinn
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Neural Decoding, Disorders of Consciousness, and the Hard Consciousness Problem. Neurology (IF 7.7) Pub Date : 2025-01-30 Joseph D Burns,David P Lerner
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Teaching NeuroImage: Black Turbinate Sign as an Early Clue of Rhino-Orbital-Cerebral Mucormycosis. Neurology (IF 7.7) Pub Date : 2025-01-29 Jim Shenchu Xie,Laura Donaldson,Edward Margolin
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Impact of the Adverse Social Exposome on Survival in Individuals With Amyotrophic Lateral Sclerosis. Neurology (IF 7.7) Pub Date : 2025-01-29 Dae-Gyu Jang,Amy J Kind,Adam Patterson,Meredith Pedde,W Ryan Powell,Eva L Feldman,Stephen A Goutman
BACKGROUND AND OBJECTIVES An adverse social exposome negatively affects many diseases, but its association with amyotrophic lateral sclerosis (ALS) survival is unknown. This study examined the association between the social exposome measure Area Deprivation Index (ADI) and ALS survival. METHODS This is a retrospective analysis of patients with ALS at the University of Michigan Pranger ALS Clinic diagnosed
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Cholesterol Variability and Dementia Risk: Finding Meaning in the Ups and Downs. Neurology (IF 7.7) Pub Date : 2025-01-29 Erin L Ferguson,Ronald M Krauss,Catherine A Schaefer
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Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults. Neurology (IF 7.7) Pub Date : 2025-01-29 Zhen Zhou,Chris Moran,Anne M Murray,Sophia Zoungas,Costan Magnussen,Trevor T-J Chong,Raj C Shah,Kerry M Sheets,Mark Nelson,Chao Zhu,Andrew M Tonkin,Stella Talic,Michael E Ernst,Suzanne G Orchard,John J McNeil,Rory Wolfe,Robyn L Woods,Johannes T Neumann,Peng Qiu,Joanne Ryan
BACKGROUND AND OBJECTIVES Lipid metabolism in older adults is affected by various factors including biological aging, functional decline, reduced physiologic reserve, and nutrient intake. The dysregulation of lipid metabolism could adversely affect brain health. This study investigated the association between year-to-year intraindividual lipid variability and subsequent risk of cognitive decline and
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Endovascular Thrombectomy for Extracranial Internal Carotid Artery Occlusions With Large Ischemic Strokes: Insights From the SELECT2 Trial. Neurology (IF 7.7) Pub Date : 2025-01-27 Santiago Ortega-Gutierrez,Aaron Rodriguez-Calienes,Deep Pujara,Clark Sitton,Milagros Galecio-Castillo,Ameer E Hassan,Michael G Abraham,Michael Chen,Spiros Blackburn,Scott E Kasner,Heena Olalde,Malik Ghannam,Muhammad S Hussain,Enrique C Leira,Mario Martínez-Galdámez,Amir Shaban,Jenny P Tsai,Hannah Roeder,Julie C Gudenkauf,Ronald Budzik,Nirav Vora,Ricardo A Hanel,Amin Aghaebrahim,Frances Colgan,Maria
BACKGROUND AND OBJECTIVES Although previous trials have established the efficacy and safety of endovascular thrombectomy (EVT) in large ischemic core strokes, most of them excluded patients with extracranial internal carotid artery (e-ICA) occlusion. We aimed to compare outcomes in patients with e-ICA occlusion and large ischemic core infarcts treated with EVT vs medical management (MM). METHODS This
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Teaching Video NeuroImage: Methamphetamine-Induced Basal Ganglia Toxicity Presenting as Parkinsonism. Neurology (IF 7.7) Pub Date : 2025-01-27 Michelle Yool Yi,Samantha Cheng,Akhil Avunoori Chandra,Nathan Farkas,Zoe Kratina-Hathaway,Charles Esenwa
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Prevalence of Pathogenic Variants and Eligibility Criteria for Genetic Testing in Patients Who Visit a Memory Clinic. Neurology (IF 7.7) Pub Date : 2025-01-27 Sven J Van Der Lee,Marc Hulsman,Rosalina Van Spaendonk,Jetske Van Der Schaar,Janna Dijkstra,Niccoló Tesi,Fred van Ruissen,Mariet Elting,Marcel Reinders,Itziar De Rojas,Corien C Verschuuren-Bemelmans,Wiesje M Van Der Flier,Mieke M van Haelst,Christa de Geus,Yolande Pijnenburg,Henne Holstege
BACKGROUND AND OBJECTIVES Identifying genetic causes of dementia in patients visiting memory clinics is important for patient care and family planning. Traditional clinical selection criteria for genetic testing may miss carriers of pathogenic variants in dementia-related genes. This study aimed identify how many carriers we are missing and to optimize criteria for selecting patients for genetic counseling
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Double Trouble in Patients With Large Core Ischemic Stroke: Intracranial Thrombo-Embolic Occlusion and Extracranial Carotid Occlusion. Neurology (IF 7.7) Pub Date : 2025-01-27 Diederik W J Dippel,Maarten Uyttenboogaart
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Reader Response: Trial Participation in Neurodegenerative Diseases: Barriers and Facilitators: A Systematic Review and Meta-Analysis. Neurology (IF 7.7) Pub Date : 2025-01-24 Yuquan Chen,Yanwei You,Jiarong He,Mingming Zhang
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Author Response: Trial Participation in Neurodegenerative Diseases: Barriers and Facilitators: A Systematic Review and Meta-Analysis. Neurology (IF 7.7) Pub Date : 2025-01-24 Daphne N Weemering,Ruben P A van Eijk
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Reader Response: Trial Participation in Neurodegenerative Diseases: Barriers and Facilitators: A Systematic Review and Meta-Analysis. Neurology (IF 7.7) Pub Date : 2025-01-24 Lu Hao
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Editor's Note: Trial Participation in Neurodegenerative Diseases: Barriers and Facilitators: A Systematic Review and Meta-Analysis. Neurology (IF 7.7) Pub Date : 2025-01-24 James E Siegler,Steven L Galetta
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État Criblé: High-Resolution MRI and Metabolism. Neurology (IF 7.7) Pub Date : 2025-01-24 Erika Layne Weil,Quentin Finn,Abdulmunaim M Eid,Christof Karmonik,Belen Pascual,Joseph C Masdeu,
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Author Response: Trial Participation in Neurodegenerative Diseases: Barriers and Facilitators: A Systematic Review and Meta-Analysis. Neurology (IF 7.7) Pub Date : 2025-01-24 Daphne N Weemering,Ruben P A van Eijk
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Teaching NeuroImage: Orbital Apex Syndrome Associated With Herpes Zoster Ophthalmicus. Neurology (IF 7.7) Pub Date : 2025-01-23 Daichi Imamura,Hajime Yoshimura,Michi Kawamoto
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Conventional MRI-Based Structural Disconnection and Morphometric Similarity Networks and Their Clinical Correlates in Multiple Sclerosis. Neurology (IF 7.7) Pub Date : 2025-01-23 Mario Tranfa,Maria Petracca,Marcello Moccia,Alessandra Scaravilli,Frederik Barkhof,Vincenzo Brescia Morra,Antonio Carotenuto,Sara Collorone,Andrea Elefante,Fabrizia Falco,Roberta Lanzillo,Luigi Lorenzini,Menno M Schoonheim,Ahmed T Toosy,Arturo Brunetti,Sirio Cocozza,Mario Quarantelli,Giuseppe Pontillo
BACKGROUND AND OBJECTIVES Although multiple sclerosis (MS) can be conceptualized as a network disorder, brain network analyses typically require advanced MRI sequences not commonly acquired in clinical practice. Using conventional MRI, we assessed cross-sectional and longitudinal structural disconnection and morphometric similarity networks in people with MS (pwMS), along with their relationship with
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Peripartum Mental Illness in Mothers With Multiple Sclerosis and Other Chronic Diseases in Ontario, Canada. Neurology (IF 7.7) Pub Date : 2025-01-22 Ruth Ann Marrie,James Bolton,Yushu Vicki Ling,Charles Bernstein,Kristen M Krysko,Ping Li,Kyla A Mckay,Priscila Pequeno,Neda Razaz,Dalia Rotstein,Karma Deakin-Harb,Colleen J Maxwell
BACKGROUND AND OBJECTIVES Peripartum mood and anxiety disorders constitute the most frequent form of maternal morbidity in the general population, but little is known about peripartum mental illness in mothers with multiple sclerosis (MS). We compared the incidence and prevalence of peripartum mental illness among mothers with MS, epilepsy, inflammatory bowel disease (IBD), and diabetes and women without