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Initial [18F]FDG PET/CT study for survival evaluation of lung transplantation patients with interstitial lung disease Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-14 Lin Chen, Jing Wang, Chentao Jin, Congcong Yu, Yan Zhong, Xiaofeng Dou, Xiaohui Zhang, Piaopiao Zhang, Juan Chen, Jingyu Chen, Mei Tian, Hong Zhang, Rui Zhou
Purpose This study aimed to investigate the role of [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in survival prediction of interstitial lung diseases (ILD) patients undergoing lung transplantation (LTx). Methods Eighty-three patients with ILD who underwent LTx were retrospectively included in this study, among whom 43 received unilateral LTx and 40 received
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Low-dose temozolomide selectively increases glioblastoma’s vascular permeability, tumor microenvironment penetration and the killing potential of systemic actinium-225 α-particle dendrimer-radioconjugates improving treatment efficacy Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-14 Rajiv Ranjit Nair, Aira Sarkar, Pooja Hariharan, Kathleen L. Gabrielson, Tony Wu, Chang Liu, Anjali Sharma, Wathsala Liyanage, Zaver M. Bhujwalla, Marie-France Penet Vidaver, Rangaramanujam M. Kannan, Stavroula Sofou
Purpose The poor prognosis of glioblastoma is mostly due to the relatively low tumor vascular permeability to therapeutics, the tumor’s vicinity to the brain, that limits treatment aggressiveness, and/or drug resistance. Methods In this study, the efficacy of systemically injected actinium-225 dendrimer-radioconjugates was evaluated in an immune-competent orthotopic GL261-C57BL/6 mouse model after
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Dynamic Client Distillation for Semi-supervised Federated Learning in A Realistic Scenario IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-14 Ning Shen, Tingfa Xu, Shiqi Huang, Zhenxiang Chen, Jianan Li
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Disentangled Pseudo-bag Augmentation for Whole Slide Image Multiple Instance Learning IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-14 Jiuyang Dong, Junjun Jiang, Kui Jiang, Jiahan Li, Linghan Cai, Yongbing Zhang
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HERON: High-Efficiency Real-Time mOtion quantification and re-acquisitioN for Fetal diffusion MRI IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-14 Jordina Aviles Verdera, Antonia Bortolazzi, Sara Neves Silva, Kelly Payette, Kamilah St. Clair, Sarah McElroy, Shaihan Malik, Joseph Hajnal, Raphael Tomi-Tricot, Mary Rutherford, Jana Hutter
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Advancing Volumetric Medical Image Segmentation via Global-Local Masked Autoencoders IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-14 Jiaxin Zhuang, Luyang Luo, Qiong Wang, Mingxiang Wu, Lin Luo, Hao Chen
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Post-COVID-19 lung disease: utility of biochemical and imaging markers in uncovering residual lung inflammation and monitoring anti-inflammatory therapy, a prospective study Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-13 Yogita Khandelwal, Manish Ora, Bela Jain, Manish Dixit, Prakash Singh, Ajmal Khan, Alok Nath, Vikas Agarwal, Sanjay Gambhir
Purpose Post-COVID-19 lung disease (PCLD) is a significant concern following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. PCLD encompasses persistent debilitating respiratory symptoms and radiological changes beyond the acute disease phase. It highlights the ongoing search to identify and manage lingering diseases. This prospective study utilizes F18-Fludeoxyglucose (FDG)
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Development of a novel anti-CEACAM5 VHH for SPECT imaging and potential cancer therapy applications Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-13 Ying Cong, Rianne Biemans, Natasja G. Lieuwes, Dennis Suijlen, Philippe Lambin, Ingrid Dijkgraaf, Matthias Bauwens, Ala Yaromina, Ludwig J. Dubois
Purpose In this study, we investigated the utility of a novel developed anti-CEACAM5 VHH for cancer diagnosis and its potential of being a targeting-moiety of VHH-drug conjugates for cancer therapy. Methods Anti-CEACAM5 VHH (6B11) affinity and specific cellular binding was confirmed by ELISA, FACS and immunofluorescence in cancer cell lines with varying CEACAM5 expression levels. Intracellular penetration
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18F-FDG PET/CT for predicting prognosis of B-cell non-Hodgkin lymphoma patients treated with chimeric antigen receptor T cells: the value of pre-infusion and M1 image Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-13 Xilan Yao, Hongrong Wang, Xiao Lei, Jialing Cui, Shuang Yao, Jigang Yang
Purpose We aimed to evaluate the prognostic value of pre- and post-infusion 18F-FDG PET/CT for B-cell non-Hodgkin lymphoma B-NHL) patients treated with anti-CD19 chimeric antigen receptor T (CAR-T) cells. Methods B-NHL patients who received CAR-T therapy and underwent 18F-FDG PET/CT examination one month before (pre-infusion) and after (M1) CAR-T infusion were collected and regularly followed up. Maximum
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SA-Seg: Annotation-Efficient Segmentation for Airway Tree Using Saliency-based Annotation IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-12 Kai Zhou, Nan Chen, Zhang Yi, Xiuyuan Xu
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Directional interactions from non-small cell lung cancer to brain glucose metabolism revealed by total-body PET imaging Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-09 Tianzheng Zhong, Yanhua Duan, Kun Li, Jianfeng Qiu, Zhaoping Cheng, Weizhao Lu
Purpose Imaging markers for lung-brain interaction and brain metastasis of non-small cell lung cancer (NSCLC) are lacking. This study aimed to explore the effect of NSCLC on brain glucose metabolism using total-body positron emission tomography (PET) imaging. Methods Fifty-six healthy controls (HCs) and 42 NSCLC patients underwent total-body PET imaging. Concentrations of serum tumor markers were obtained
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[68Ga]Ga-NOTA-T4 ImmunoPET imaging for evaluating TROP2 expression in patients with solid tumors Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-09 Donglang Jiang, Zhaohui Chu, Yanfei Wu, You Zhang, Yao Liu, Qi Ge, Yue Gu, Zunguo Du, Yuanyuan Cheng, Xiwen Xu, Yuan Huang, Dong Xu, Yihui Guan, Weijun Wei, Fang Xie
Purpose Gallium-68 (68Ga)-labeled [68Ga]Ga-NOTA-T4 immuno-positron emission tomography (immunoPET) holds great promise as a non-invasive technique for visualizing the expression of trophoblast cell-surface antigen 2 (TROP2). This approach may potentially assist in making clinical decisions regarding TROP2-targeted therapies. The present study aims to evaluate the utility of [68Ga]Ga-NOTA-T4 PET/CT
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To contrast or not to contrast? Evaluating the diagnostic accuracy of hepatobiliary contrast agents in liver FDG-PET/MR: a prospective study Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-09 Luigi Asmundo, Felipe Furtado, Francis Delaney, Mojtahed Amirkasra, Azadeh Hajati, Abdar Esfahani Shadi, Avinash Kambadakone, Lawrence Blaszkowsky, Jeffrey Clark, David Ryan, Onofrio Antonio Catalano
Purpose The role of hepatobiliary contrast-enhanced imaging in the evaluation of liver malignancies in FDG-PET/MR remains underexplored. The aim of this study was to assess the diagnostic performance of stand-alone FDG-PET, non-contrast-enhanced (NCE) PET/MR, and contrast-enhanced (CE) PET/MR with and without hepatobiliary phase (HBP). Methods This prospective, single-center diagnostic accuracy study
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From Genome to Phenome: Opportunities and Challenges of Molecular Imaging J Nucl. Med. (IF 9.1) Pub Date : 2025-05-08 Mei Tian, Leroy Hood, Arturo Chiti, Markus Schwaiger, Satoshi Minoshima, Yasuyoshi Watanabe, Keon Wook Kang, Hong Zhang
The study of the human phenome is essential for understanding the complexities of wellness and disease and their transitions, with molecular imaging being a vital tool in this exploration. Molecular imaging embodies the 4 principles of human phenomics: precise measurement, accurate calculation or analysis, well-controlled manipulation or intervention, and innovative invention or creation. Its application
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Determination of the Intralesional Distribution of Theranostic 124I-Omburtamab Convection-Enhanced Delivery in Treatment of Diffuse Intrinsic Pontine Glioma J Nucl. Med. (IF 9.1) Pub Date : 2025-05-08 Alexandre França Velo, Alexandra Giantini Larsen, John L. Humm, Pat Zanzonico, Sofia Haque, Mark Souweidane, Neeta Pandit-Taskar
This phase 1, dose-escalation study examined the use of the radiolabeled antibody 124I-Omburtamab delivered directly to brain-stem tumors via convection-enhanced delivery (CED). CED bypasses the blood–brain barrier by injecting the agent under the pressure of a peristaltic pump to convectively drive the therapeutic agent through the brain tissue and tumor compartment, enabling high concentrations at
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Quantitative Total-Body Imaging of Blood Flow with High-Temporal-Resolution Early Dynamic 18F-FDG PET Kinetic Modeling J Nucl. Med. (IF 9.1) Pub Date : 2025-05-08 Kevin J. Chung, Abhijit J. Chaudhari, Lorenzo Nardo, Terry Jones, Moon S. Chen, Ramsey D. Badawi, Simon R. Cherry, Guobao Wang
Visual Abstract
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A Vision for Gastrin-Releasing Peptide Receptor Targeting for Imaging and Therapy: Perspective from Academia and Industry J Nucl. Med. (IF 9.1) Pub Date : 2025-05-08 Clément Morgat, Heying Duan, Simone Dalm, Elif Hindié, Thomas Günther, Bernd J. Krause, Vasko Kramer, Florine Cavelier, Andrew W. Stephens, Stephen Moran, Laura Lamb, Andrei Iagaru
The gastrin-releasing peptide receptor (GRPR) is overexpressed in various cancers, including prostate cancer, breast cancer, small cell and non–small cell lung cancer, uterine and ovarian cancer, colon cancer, and gastrointestinal stromal tumors. This makes GRPR a multicancer target for theranostics, that is, molecular imaging and therapy. Here, we explore the current state of GRPR-targeted theranostics
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[11C]Carfentanil PET Whole-Body Imaging of μ-Opioid Receptors: A First in-Human Study J Nucl. Med. (IF 9.1) Pub Date : 2025-05-08 Jacob G. Dubroff, Chia-Ju Hsieh, Corinde E. Wiers, Hsiaoju Lee, Alexander Schmitz, Elizabeth J. Li, Erin K. Schubert, Robert H. Mach, Henry R. Kranzler
μ-opioid receptors (MORs) are G-coupled receptors widely expressed in the brain and body. MORs have a high affinity for both endogenous opioids such as β-endorphins and exogenous opioids such as fentanyl. They mediate pain and reward and have been implicated in the pathophysiology of opioid, cocaine, and other substance use disorders. Using an instrument with a long axial field of view and the MOR-selective
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[11C]ZTP-1: An Effective Short-Lived Radioligand for PET of Rat and Monkey Brain Phosphodiesterase Type 4 Subtype B J Nucl. Med. (IF 9.1) Pub Date : 2025-05-08 Qunchao Zhao, Jeih-San Liow, Joo Eun Jee, Jose Montero Santamaria, Matilah Pamie-George, Cheryl Morse, Shawn Wu, Sami S. Zoghbi, Sung Won Kim, Robert B. Innis, Victor W. Pike, Sanjay Telu
Phosphodiesterase type 4 subtype B (PDE4B) selectively hydrolyzes cyclic adenosine monophosphate to enact numerous downstream signaling events. PDE4B is widely expressed in the brain and is implicated in several neuropsychiatric disorders. Moreover, PDE4B inhibition shows antiinflammatory and antidepressant-like effects in animal studies. [18F]PF-06445974 has been developed to image human brain PDE4B
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Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis J Nucl. Med. (IF 9.1) Pub Date : 2025-05-08 Randy Yeh, Fresia Pareja, Parnian Shobeiri, Dara Ross, Vetri S. Jayaprakasam, Ali Aria Razmaria, Joshua Z. Drago, Audrey Mauguen, Serge K. Lyashchenko, Brian M. Zeglis, Jason S. Lewis, Gary A. Ulaner
Trastuzumab deruxtecan (T-DXd), a human epidermal growth factor receptor 2 (HER2)–targeted antibody–drug conjugate, demonstrated remarkable efficacy in previously treated patients with HER2-low metastatic breast cancer (mBC), marking a new therapeutic option for this patient population. Prior studies with HER2 PET using 89Zr-radiolabeled antibodies were limited by high rates of imaging false positives
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First-in-Human Study of 18F-Labeled PET Tracer for Glutamate AMPA Receptor [18F]K-40: A Derivative of [11C]K-2 J Nucl. Med. (IF 9.1) Pub Date : 2025-05-08 Sadamitsu Ichijo, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Tomoyuki Miyazaki, Tsuyoshi Eiro, Yuuki Takada, Ryunosuke Iai, Akane Sano, Masaki Sonoda, Yutaro Takayama, Yuichi Kimura, Takuya Takahashi
Visual Abstract
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VesselDiffusion: 3D Vascular Structure Generation Based on Diffusion Model IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-09 Zhanqiang Guo, Zimeng Tan, Jianjiang Feng, Jie Zhou
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Measurement of cyclosporin induced changes in P-glycoprotein function at the human blood-brain barrier using [18F]MC225 and PET Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-08 Pascalle Mossel, Giordana Salvi de Souza, Antoon T. M. Willemsen, Gilles N. Stormezand, Nicola A. Colabufo, Jun Toyohara, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Anna L. Bartels, Gert Luurtsema
Introduction P-glycoprotein (P-gp) or multidrug-resistance protein is one of the most extensively studied efflux transporters at the blood-brain barrier (BBB). Changes in P-gp function are associated with several neurodegenerative and psychiatric diseases, including Alzheimer’s disease, Parkinson’s disease and schizophrenia and with the bioavailability of several pharmaceuticals in the brain, causing
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Cost-utility analysis of 177Lu-PSMA-617 radioligand therapy in second-line and third-line treatment for metastatic castration-resistant prostate cancer (mCRPC) in Germany Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-08 Carolin Brinkmann, Richard P. Baum, Tom Stargardt
Purpose To evaluate the cost-effectiveness of 177Lu-PSMA-617 radioligand therapy (PRLT) in metastatic castration-resistant prostate cancer (mCRPC) in Germany by comparing (I) PRLT plus standard-of-care (SoC) versus SoC alone as third-line treatment and (II) PRLT versus second-line cabazitaxel chemotherapy. Methods Cohort state-transition models were developed with (I) four health states (treatment
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HER2-targeted PET/CT imaging provides potential biomarkers for differentiating HER2-zero, -low, and -positive breast cancer Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-08 Yuan Gao, Lei Yin, Xiaojiang Duan, Zijian Fu, Qian Liu, Jinzhi Chen, Ling Xin, Xiaojuan Zhu, Hongyu Xiang, Ling Xu, Jingming Ye, Meng Liu
Purpose Human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugates (ADCs) in breast cancer is progressing rapidly, asking for precise categorization of HER2 expression. Our aim was to explore the HER2-affibody uptake characteristics in breast cancer and to find potential biomarkers for differentiating HER2 status, in comparison with 18F-FDG PET/CT. Methods In this prospective
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Noninvasive diagnosis and classification of kidney transplantation rejection by 18F-FAPI-04 PET/CT Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-08 Sulin Luo, Mimi Xu, Rongfang Shen, Meifang Wang, Qinyun Wu, Tianlu Zhang, Zhenpeng Jin, Pengpeng Yan, Luying Guo, Jingyi Zhou, Qin Zhou, Huiping Wang, Kui Zhao, Xinhui Su, Rending Wang
Purpose Rejection, especially chronic rejection is a key factor influencing the prognosis of kidney transplantation patients. While 18F-fibroblast activation protein inhibitor (FAPI)-04 PET/CT has been widely utilized for diagnosing various diseases, its diagnostic efficacy in kidney transplant rejection remains unexplored. Methods In this study, 24 kidney transplant recipients were prospectively enrolled
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Head-to-head comparison of peptide-based and nanobody-based radiotracers in detecting PD-L1 expression in non-small cell lung cancer Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-08 Yanfei Wu, Hao Wang, Yue Gu, You Zhang, Guanglei Li, Yuan Huang, Min Cao, Xiaofeng Chen, Yihui Guan, Dong Xu, Weijun Wei, Fang Xie
Background Immunotherapy based on programmed cell death protein receptor 1 and its ligand (PD-1/PD-L1) has become an important method for treating non-small cell lung cancer (NSCLC). Peptide-based and nanobody-based PET tracers offer potential advantages in PD-L1 detection, yet their comparative tumor uptake and biodistribution remain unclear. This study aimed to evaluate and compare [68Ga]Ga-DOTA-WL12
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The predictive value of multiparametric MRI combined with [18F]PSMA-1007 PET/CT for the pathological upgrade in prostate cancer: a multicenter study Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-08 Jian Xu, Haisong Chen, Lixuan Chen, Tiancheng Li, Heng Lin, Shuying Bian, Qi Lin, Yuandi Zhuang, Yingnan Xue, Yunjun Yang, Xinhui Su, Fei Yao
Purpose This study aimed to develop a predictive model that integrates parameters derived from preoperative multiparametric magnetic resonance imaging (mpMRI) and [18F]PSMA-1007 PET/CT for reliably predicting pathological upgrading from systematic biopsy (SB) to radical prostatectomy (RP) specimens. Methods We ultimately retrospectively analyzed 163 patients with biopsy-confirmed localized prostate
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[18F]FDG PET/CT imaging in a patient with diffuse skeletal muscle metastasis of thyroid carcinoma Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-08 Yanwei Wang, Jialin Xiang, Zhaohui Zhu
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Anatomy-Aware Deep Unrolling for Task-Oriented Acceleration of Multi-Contrast MRI IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-08 Yuzhu He, Chunfeng Lian, Ruyi Xiao, Fangmao Ju, Chao Zou, Zongben Xu, Jianhua Ma
Multi-contrast magnetic resonance imaging (MC-MRI) plays a crucial role in clinical practice. However, its performance is hindered by long scanning times and the isolation between image acquisition and downstream clinical diagnoses/treatments. Despite the activated research on accelerated MC-MRI, few existing studies prioritize personalized imaging tailored to individual patient characteristics and
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Organ and tumour dosimetry of 177Lu-rhPSMA-10.1, a novel PSMA-targeted therapy: results from a Phase I trial Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-06 James Nagarajah, Hyun Kim, Luke Nordquist, Vikas Prasad, Nathaniel Scott, Daniel Stevens, Benjamin Fongenie, Joseph Osborne
Purpose To evaluate tumour and normal organ dosimetry of PSMA-targeted RLT 177Lu-rhPSMA-10.1. Methods PSMA-positive mCRPC patients experiencing disease progression following standard-of-care treatment were enrolled and underwent ≤ 3 cycles of 5.55 or 7.40 GBq 177Lu-rhPSMA-10.1 at 6-week intervals. Multi-bed SPECT/CT was conducted 3-, 24-, 48-, and 168-hours post-administration to calculate tumour and
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Metabolic characterization and radiomics-based composite model for breast cancer immune microenvironment types using 18F-FDG PET/CT Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-06 Yuan Gao, Zijian Fu, Xiaojuan Zhu, Hongfeng Li, Lei Yin, Caixia Wu, Jinzhi Chen, Yulong Chen, Li Liang, Jingming Ye, Ling Xu, Meng Liu
Purpose The intricateness of tumor immune microenvironment types (TIMTs) complicates identifying responders to immune checkpoint inhibitors (ICIs). Our purpose was to explore the metabolic characteristics of TIMTs in breast cancer using 18F-fluorodeoxyglucose (FDG) PET/CT and to establish radiomics-based predictive models for TIMTs. Methods Consecutive 207 breast cancer patients (211 primary lesions)
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Evidence for brain glial activity in chronic migraine patients: a [11C] PBR28 PET/MR study Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-06 Yan Chang, Xiwan Zhang, Shaobo Xiao, Jiajin Liu, Yuan Wang, Jingbin Song, Huaping Fu, Yungang Li, Hui Su, Huijie Yi, Wenjie Su, Nan Gao, JinJing Zhao, Ruimin Wang, Ruozhuo Liu
Purpose Although neuroinflammation may play a key role in the pathology of migraine and its progression to chronic migraine (CM), its specific involvement-particularly the role of microglia- remains unclear. We investigated whether neuroinflammation is involved in the pathophysiology of CM and whether pro-inflammatory signals are associated with its clinical features. Methods Nineteen individuals with
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[99mTc]Tc-antigranulocyte scintigraphy for prediction of bone marrow reserve prior to radioligand therapy in patients with metastatic castration resistant prostate cancer Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-06 Sophie Carina Kunte, Astrid Delker, Adrien Holzgreve, Mathias J. Zacherl, Maximilian Scheifele, Jozefina Casuscelli, Franz Josef Gildehaus, Marcus Unterrainer, Harun Ilhan, Rudolf A. Werner, Lena M. Unterrainer
Purpose Radioligand therapy (RLT) targeting PSMA (prostate-specific membrane antigen) has transformed the treatment of metastatic castration-resistant prostate cancer (mCRPC). However, bone marrow depletion remains a common side effect, particularly in patients with extensive bone metastases or prior myelotoxic therapies. This study evaluated [99mTc]Tc-antigranulocyte scintigraphy to assess bone marrow
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Rethinking boundary detection in deep learning-based medical image segmentation Med. Image Anal. (IF 10.7) Pub Date : 2025-05-06 Yi Lin, Dong Zhang, Xiao Fang, Yufan Chen, Kwang-Ting Cheng, Hao Chen
Medical image segmentation is a pivotal task within the realms of medical image analysis and computer vision. While current methods have shown promise in accurately segmenting major regions of interest, the precise segmentation of boundary areas remains challenging. In this study, we propose a novel network architecture named CTO, which combines Convolutional Neural Networks (CNNs), Vision Transformer
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Dino-Reg: Efficient Multimodal Image Registration with Distilled Features IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-06 Xinrui Song, Xuanang Xu, Jiajin Zhang, Diego Machado Reyes, Pingkun Yan
Medical image registration is a crucial process for aligning anatomical structures, enabling applications such as atlas mapping, longitudinal analysis, and multimodal data fusion. This paper introduces DINO-Reg, an adaptation-free registration method leveraging the vision foundation model, DINOv2, to extract features for deformable 3D medical image alignment. Although DINOv2 was originally trained
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Machine Learning Approach to 3×4 Mueller Polarimetry for Complete Reconstruction of Diagnostic Polarimetric Images of Biological Tissues IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-06 Sooyong Chae, Tongyu Huang, Omar Rodríguez-Núñez, Théotim Lucas, Jean-Charles Vanel, Jérémy Vizet, Angelo Pierangelo, Gennadii Piavchenko, Tsanislava Genova, Ajmal Ajmal, Jessica C. Ramella-Roman, Alexander Doronin, Hui Ma, Tatiana Novikova
The translation of imaging Mueller polarimetry to clinical practice is often hindered by large footprint and relatively slow acquisition speed of the existing instruments. Using polarization-sensitive camera as a detector may reduce instrument dimensions and allow data streaming at video rate. However, only the first three rows of a complete 4×4 Mueller matrix can be measured. To overcome this hurdle
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Total-body 11C-PIB PET/CT imaging of systemic amyloidosis: inter-organ connectivity in cardiac amyloidosis for prognostic insights Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-05 Zhihui Hong, Song Xue, Josef Yu, Raffaella Calabretta, David Haberl, Zewen Jiang, Stefan Grünert, Dietrich Beitzke, Andreas Kammerlander, Marcus Hacker, Xiang Li
Background Amyloidosis is a systemic disorder characterized by amyloid fibril deposition in multiple organs, including the heart, brain, liver, kidneys, and lungs, leading to organ dysfunction and affecting survival. In cardiac amyloidosis (CA), where the heart is primarily affected, the broader impact on other organs, particularly the brain, is not fully understood. This study aimed to assess the
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An End-to-End Deep Learning Generative Framework for Refinable Shape Matching and Generation IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-05 Soodeh Kalaie, Andy Bulpitt, Alejandro F. Frangi, Ali Gooya
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Representation learning in PET scans enhanced by semantic and 3D position specific characteristics IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-05 Theodoros P. Vagenas, Maria Vakalopoulou, Christos Sachpekidis, Antonia Dimitrakopoulou-Strauss, George K. Matsopoulos
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Comparison of 18F-DPA714 PET/MRI and 18F-FDG PET/CT in patients with autoimmune encephalitis: a cross-sectional study Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-03 Huanyu Meng, Xiaoyu Chen, Lu He, Hangxing Chunyu, Qinming Zhou, Jin Wang, Qian Qu, Wangxi Hai, Yu Zhang, Biao Li, Sheng Chen, Min Zhang
Background and aim The positive detection rate of MRI in autoimmune encephalitis (AIE) patients is low, often failing to make a rapid and accurate localization diagnosis. Both 18F-DPA714 and 18F-FDG PET imaging techniques have shown their advantages in the diagnosis of AIE. Therefore, the aim of this study was to conduct a head-to-head comparison of the diagnostic value between 18F-DPA714 and 18F-FDG
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PET imaging utilization and trends in Germany: a comprehensive survey Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-03 Adrien Holzgreve, Dirk Hellwig, Henryk Barthel, Ambros J. Beer, Carsten Kobe, Constantin Lapa, Matthias Miederer, Sarah Schwarzenböck, Robert Seifert, Andrei Todica, Ken Herrmann, Frank M. Bengel, Michael Schäfers, Detlef Moka, Markus Luster, Wolfgang P. Fendler
Introduction PET imaging is a key diagnostic procedure in clinical routine worldwide. While public figures on PET volume are available in many countries, until now these numbers were not publicly known for Germany. Methods On behalf of the PET committee of the German Society of Nuclear Medicine, we conducted a comprehensive survey among PET centers in Germany to collect data on PET imaging, including
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XCAT 3.0: A comprehensive library of personalized digital twins derived from CT scans Med. Image Anal. (IF 10.7) Pub Date : 2025-05-03 Lavsen Dahal, Mobina Ghojoghnejad, Liesbeth Vancoillie, Dhrubajyoti Ghosh, Yubraj Bhandari, David Kim, Fong Chi Ho, Fakrul Islam Tushar, Sheng Luo, Kyle J. Lafata, Ehsan Abadi, Ehsan Samei, Joseph Y. Lo, W. Paul Segars
Virtual Imaging Trials (VIT) offer a cost-effective and scalable approach for evaluating medical imaging technologies. Computational phantoms, which mimic real patient anatomy and physiology, play a central role in VITs. However, the current libraries of computational phantoms face limitations, particularly in terms of sample size and heterogeneity. Insufficient representation of the population hampers
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[18F]flutemetamol uptake in the colon of a memory clinic population and its association with brain amyloidosis and the gut microbiota profile: an exploratory study Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-02 Giulia Quattrini, Elena Gatti, Débora Elisa Peretti, Marco Aiello, Claire Chevalier, Aurelien Lathuiliere, Rahel Park, Michela Pievani, Marco Salvatore, Max Scheffler, Annamaria Cattaneo, Giovanni B. Frisoni, Valentina Garibotto, Moira Marizzoni
Purpose Some Alzheimer’s disease (AD) patients report gastro-intestinal symptoms and present alterations in the gut microbiota (GM) composition. Elevated colonic amyloid immunoreactivity has been shown in patients and animal models. We evaluated the colonic uptake of the amyloid positron emission tomography (PET) imaging agent [18F]flutemetamol (FMM) in a memory clinic population and investigated its
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Towards Foundation Models and Few-Shot Parameter-Efficient Fine-Tuning for Volumetric Organ Segmentation Med. Image Anal. (IF 10.7) Pub Date : 2025-05-02 Julio Silva-Rodríguez, Jose Dolz, Ismail Ben Ayed
The recent popularity of foundation models and the pre-train-and-adapt paradigm, where a large-scale model is transferred to downstream tasks, is gaining attention for volumetric medical image segmentation. However, current transfer learning strategies devoted to full fine-tuning for transfer learning may require significant resources and yield sub-optimal results when the labeled data of the target
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TIER-LOC: Visual Query-based Video Clip Localization in fetal ultrasound videos with a multi-tier transformer Med. Image Anal. (IF 10.7) Pub Date : 2025-05-02 Divyanshu Mishra, Pramit Saha, He Zhao, Netzahualcoyotl Hernandez-Cruz, Olga Patey, Aris T. Papageorghiou, J. Alison Noble
In this paper, we introduce the Visual Query-based task of Video Clip Localization (VQ-VCL) for medical video understanding. Specifically, we aim to retrieve a video clip containing frames similar to a given exemplar frame from a given input video. To solve the task, we propose a novel visual query-based video clip localization model called TIER-LOC. TIER-LOC is designed to improve video clip retrieval
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Automatic quality control of brain 3D FLAIR MRIs for a clinical data warehouse Med. Image Anal. (IF 10.7) Pub Date : 2025-05-02 Sophie Loizillon, Simona Bottani, Aurélien Maire, Sebastian Ströer, Lydia Chougar, Didier Dormont, Olivier Colliot, Ninon Burgos, APPRIMAGE Study Group
Clinical data warehouses, which have arisen over the last decade, bring together the medical data of millions of patients and offer the potential to train and validate machine learning models in real-world scenarios. The quality of MRIs collected in clinical data warehouses differs significantly from that generally observed in research datasets, reflecting the variability inherent to clinical practice
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Deep implicit optimization enables robust learnable features for deformable image registration Med. Image Anal. (IF 10.7) Pub Date : 2025-05-02 Rohit Jena, Pratik Chaudhari, James C. Gee
Deep Learning in Image Registration (DLIR) methods have been tremendously successful in image registration due to their speed and ability to incorporate weak label supervision at training time. However, existing DLIR methods forego many of the benefits and invariances of optimization methods. The lack of a task-specific inductive bias in DLIR methods leads to suboptimal performance, especially in the
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Transfontanelle Thermoacoustic Imaging of Intraventricular Brain Hemorrhages in Live Sheep IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-02 Md Tarikul Islam, Juliana Benavides, Ravi Prakash, Mohsin Zafar, Laura McGuire, Fady Charbel, Amanda P. Siegel, Danilo Erricolo, James Lin, Juri G. Gelovani, Kamran Avanaki
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A Dual-Task Synergy-Driven Generalization Framework for Pancreatic Cancer Segmentation in CT Scans IEEE Trans. Med. Imaging (IF 8.9) Pub Date : 2025-05-02 Jun Li, Yijue Zhang, Haibo Shi, Minhong Li, Qiwei Li, Xiaohua Qian
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Should end-to-end deep learning replace handcrafted radiomics? Eur. J. Nucl. Med. Mol. Imaging (IF 8.6) Pub Date : 2025-05-02 Irène Buvat,Joyita Dutta,Abhinav K Jha,Eliot Siegel,Fereshteh Yousefirizi,Arman Rahmim,Tyler Bradshaw
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Radiances of Cerenkov-Emitting Radionuclides on the In Vivo Imaging System J Nucl. Med. (IF 9.1) Pub Date : 2025-05-01 Edwin C. Pratt, Travis M. Shaffer, David Bauer, Jason S. Lewis, Jan Grimm
Cerenkov (or Cherenkov) luminescence occurs when charged particles exceed the phase velocity of a given medium. Cerenkov as a modality has gained interest for visualization of numerous radionuclides. However, reported Cerenkov intensities are limited or provided as theoretic fluence estimates. Here, we present the largest experimental dataset of Cerenkov-emitting radionuclides using the in vivo imaging
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Bioanalytic Hybrid System Merging 3-Dimensional Cell Culture and Chromatographic Precision for Unprecedented Preclinical Insights in Molecular Imaging J Nucl. Med. (IF 9.1) Pub Date : 2025-05-01 Verena Pichler, Verena Schwingenschlögl-Maisetschläger, Irem Duman, Xavier Monforte, Stefanie Ponti, Lukas Zimmermann, Elma Joldic, Monika Dumanic, Chrysoula Vraka, Marcus Hacker, Christian Kraule, Andreas Herbert Teuschl-Woller
We introduce a unique bioanalytic hybrid system for the preclinical assessment of radiotracer candidates, combining a 3-dimensional cell culture on an artificial extracellular matrix functioning as a stationary phase and a chromatographiclike system array. Methods: Silk fibroin sponges were applied to simulate an extracellular matrix and to function as a stationary phase. Different cell lines were
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Reduced Renal Uptake of Various Radiopharmaceuticals with Sodium Paraaminohippurate Coadministration in a Rat Model J Nucl. Med. (IF 9.1) Pub Date : 2025-05-01 Marian Meckel, Stefanie Ehrenberg, Theresa Schmidt, Philipp Ritt, Margret I. Moré, Ralf Bergmann, Domokos Mathe, Konstantin Zhernosekov
The coinfusion of amino acids with targeted radiopharmaceutical therapy aims to reduce renal toxicity. Unfortunately, this requires a prolonged, large-volume infusion and often results in side effects such as nausea, vomiting, and hyperkalemia. Sodium paraaminohippurate is a nontoxic compound that has historically been used to measure renal plasma flow. It is excreted by the kidneys via glomerular
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Measuring Total Metabolic Tumor Volume from 18F-FDG PET: A Reality Check J Nucl. Med. (IF 9.1) Pub Date : 2025-05-01 Ronald Boellaard, Gerben J.C. Zwezerijnen, Irène Buvat, Laurence Champion, Narinée Hovhannisyan-Baghdasarian, Fanny Orlhac, Anne I.J. Arens, Daphne Lobeek, Filiz Celik, Cristina Mitea, Julia E. Huijbregts, Nelleke Tolboom, Bart de Keizer, Roelf Valkema, Floris H.P. van Velden, Petra Dibbets-Schneider, Sanne E. Wiegers, Pieternella J. Lugtenburg, Sally F. Barrington, Josée M. Zijlstra
Measuring total metabolic tumor volume (TMTV) on 18F-FDG PET/CT images in clinical practice requires a fast, reliable, and easy-to-perform multilesional segmentation workflow. We conducted a field test to derive total metabolic volumes using 5 representative baseline 18F-FDG PET/CT scans from patients with diffuse large B-cell lymphoma. The scans were transferred to 10 different sites or readers who
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The Use of Maximum-Intensity Projections and Deep Learning Adds Value to the Fully Automatic Segmentation of Lesions Avid for [18F]FDG and [68Ga]Ga-PSMA in PET/CT J Nucl. Med. (IF 9.1) Pub Date : 2025-05-01 Cláudia S. Constantino, Francisco P.M. Oliveira, Marisa Machado, Susana Vinga, Durval C. Costa
This study investigated the added value of using maximum-intensity projection (MIP) images for fully automatic segmentation of lesions using deep learning (DL) in [18F]FDG and [68Ga]Ga-prostate-specific membrane antigen (PSMA) PET/CT scans. Methods: We used 489 staging [18F]FDG PET/CT scans from patients diagnosed with melanoma, lymphoma, or lung cancer (391 scans for training and 98 for internal testing)
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MHC-I–Driven Antitumor Immunity Counterbalances Low Absorbed Doses of Radiopharmaceutical Therapy J Nucl. Med. (IF 9.1) Pub Date : 2025-05-01 Julie Constanzo, Aliasghar Parach, Timothee David, Joshua Karam, Frank Bruchertseifer, Alfred Morgenstern, Marta Jarlier, Manuel Bardiès, Emmanuel Deshayes, Amelie Gudin-de-Vallerin, Florence Boissière-Michot, Evelyne Lopez-Crapez, Jean-Pierre Pouget
Preclinical and clinical studies increasingly show that the immune response plays a major role in radiotherapy. Here, we investigated the role of major histocompatibility complex class I (MHC-I) molecules recognized by cytotoxic CD8+ T cells in the response to radiopharmaceutical therapy (RPT). Methods: Two murine melanoma cell lines that express low and high MHC-I levels (B16F10 and B16K1, respectively)
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Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning J Nucl. Med. (IF 9.1) Pub Date : 2025-05-01 Carlos Vinícius Gomes, Yizhou Chen, Isabel Rauscher, Song Xue, Andrei Gafita, Jiaxi Hu, Robert Seifert, Lorenzo Mercolli, Julia Brosch-Lenz, Jimin Hong, Marc Ryhiner, Sibylle Ziegler, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Thiago Viana Miranda Lima, Kuangyu Shi
Single-time-point (STP) image-based dosimetry offers a more convenient approach for clinical practice in radiopharmaceutical therapy (RPT) compared with conventional multiple-time-point image-based dosimetry. Despite numerous advancements, current STP methods are limited by the need for strict and late timing in data acquisition, posing challenges in routine clinical settings. This study introduces
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Assessment of [177Lu]Lu-DOTATATE Dosimetry from High-Speed Whole-Body Recordings Provided by a 360° Cadmium–Zinc–Telluride Camera Compared with Results from a Conventional Anger-Camera Protocol J Nucl. Med. (IF 9.1) Pub Date : 2025-05-01 Timothée Zaragori, Elodie Chevalier, Quentin Citerne, Véronique Roch, Gabriela Hossu, Pierre-Yves Marie, Caroline Boursier, Laetitia Imbert
Absorbed doses (ADs) may be calculated through serial conventional SPECT imaging after therapeutic [177Lu]Lu-DOTATATE injection but with recording times too long for clinical routine. The aim of this study was to determine whether activity concentrations and ADs calculated from a high-speed whole-body 360° cadmium–zinc–telluride (CZT) SPECT camera are comparable to those provided by conventional SPECT