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The argument framework is a flexible approach to evidence in healthcare Nat. Med. (IF 82.9) Pub Date : 2024-04-26 Jonathan Fuller, Benjamin Chin-Yee, Ross E. G. Upshur
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Bispecific T cell engager therapy for refractory rheumatoid arthritis Nat. Med. (IF 82.9) Pub Date : 2024-04-26 Laura Bucci, Melanie Hagen, Tobias Rothe, Maria Gabriella Raimondo, Filippo Fagni, Carlo Tur, Andreas Wirsching, Jochen Wacker, Artur Wilhelm, Jean-Philippe Auger, Milena Pachowsky, Markus Eckstein, Stefano Alivernini, Angelo Zoli, Gerhard Krönke, Stefan Uderhardt, Aline Bozec, Maria-Antonietta D’Agostino, Georg Schett, Ricardo Grieshaber-Bouyer
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Audio long read: Why loneliness is bad for your health Nature (IF 64.8) Pub Date : 2024-04-26
Listen to an audio version of a recent Nature Feature.
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Could a rare mutation that causes dwarfism also slow ageing? Nature (IF 64.8) Pub Date : 2024-04-26
People with Laron syndrome have a low risk of heart disease and a number of other age-related disorders, hinting at strategies for new treatments.
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Future of Humanity Institute shuts: what’s next for ‘deep future’ research? Nature (IF 64.8) Pub Date : 2024-04-26
Researchers from several disciplines hope to predict — and prevent — scenarios that pose risks to humanity.
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Garden-variety fungus is an expert at environmental clean-ups Nature (IF 64.8) Pub Date : 2024-04-25
The common fungus Aspergillus niger removes both heavy metals and organic pollutants from its surroundings.
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Air-travel climate-change emissions detailed for nearly 200 nations Nature (IF 64.8) Pub Date : 2024-04-25
Carbon emissions from flights that departed from low- and middle-income countries in 2019 totalled 417 million tonnes.
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Rat neurons repair mouse brains — and restore sense of smell Nature (IF 64.8) Pub Date : 2024-04-25
Scientists develop hybrid mice by filling in missing cells and structures in their brains with rat stem cells.
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Hello puffins, goodbye belugas: changing Arctic fjord hints at our climate future Nature (IF 64.8) Pub Date : 2024-04-25
Stunning images show an ecosystem’s upheaval as it warms at an alarming pace.
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Scientists urged to collect royalties from the ‘magic money tree’ Nature (IF 64.8) Pub Date : 2024-04-25
By joining a collecting society, researchers can ensure they are paid when copyrighted book content and papers are reproduced.
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Daily briefing: How an unlikely friendship with Jung influenced Pauli’s physics Nature (IF 64.8) Pub Date : 2024-04-25
A patient-analyst relationship to psychoanalyst Carl Jung that evolved into a friendship deeply influenced physicist Wolfgang Pauli’s work. Plus, organoids shed light on cancer and other diseases, and medieval graves reveal secrets of a mysterious nomadic people.
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NIH pay raise for postdocs and PhD students could have US ripple effect Nature (IF 64.8) Pub Date : 2024-04-25
Salary increases for the 17,000-plus recipients of an NIH research award could lead to increases in other academic settings.
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Bird flu in US cows: is the milk supply safe? Nature (IF 64.8) Pub Date : 2024-04-25
Pasteurized milk is probably not a threat to people, but fresh milk droplets on milking equipment could be spreading the virus in a herd.
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Judge dismisses superconductivity physicist’s lawsuit against university Nature (IF 64.8) Pub Date : 2024-04-25
Ranga Dias sued his university, in part, for allegedly conducting a biased investigation, which found he had committed extensive scientific misconduct.
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Daily briefing: The origins of bioluminescence in animals date back over half a billion years Nature (IF 64.8) Pub Date : 2024-04-24
Octocorals probably evolved the ability to make light when the first animals developed eyes. Plus, the WHO has redefined ‘airborne transmission’ and how artificial intelligence is changing weapons of war.
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How DNA encodes the start of transcription Science (IF 56.9) Pub Date : 2024-04-26 Jun Wang, Vikram Agarwal
The central dogma of molecular biology outlines the flow of genetic information from DNA to RNA to proteins. With a limited vocabulary of four nucleotides (A, C, G, and T), DNA encodes an extensive instruction set, including the chromosomal positions where RNAs begin to be transcribed and the magnitudes of their expression. This process, known as transcription initiation (1), begins at transcription
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When I use a word . . . The languages of medicines—British Approved Names BMJ (IF 105.7) Pub Date : 2024-04-26 Jeffrey K Aronson
Approved names of medicines, later known as British Approved Names, were introduced in the UK in the 1940s, as part of wartime efforts to ensure the supply of important medicines, including antimalarial drugs manufactured in Germany. Giving them approved names allowed any manufacturer to market a product containing the medicine, which would otherwise only be available as a branded product. Such products
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It’s early days in the collaborative process of reforming medical education and training BMJ (IF 105.7) Pub Date : 2024-04-25 Colin Melville
Oliver and Vaughan outline their concerns about the General Medical Council’s vision for reforming education and training.1 They focused on the areas of change we set out, but ignored the principles that underpin our regulatory approach—patient safety; maintaining standards; outcomes, not time; competency; proportionality; and support for diversity. By not taking these into account they misunderstand
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Medscape caves in on courses funded by tobacco giant Philip Morris, while medics fear global push into medical education BMJ (IF 105.7) Pub Date : 2024-04-26 Hristio Boytchev
Clinic demonstrations, podcasts, and TV shows: Hristio Boytchev reveals how an ambitious deal between a leading medical education provider and the tobacco industry collapsed this week The medical education provider Medscape has bowed to pressure and agreed to permanently remove a series of accredited medical education courses on smoking cessation funded by the tobacco industry giant Philip Morris International
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Stop tobacco industry sponsorship of continuing medical education BMJ (IF 105.7) Pub Date : 2024-04-26 Ruth E Malone
This malign industry must not be allowed to influence clinicians’ learning In a troubling development for tobacco control, Medscape, a continuing education website for health professionals, was recently discovered to be promoting a series on smoking cessation sponsored by tobacco company Philip Morris International (PMI).1 Observers will note the bizarre incongruity of education programmes for doctors
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Achieving more equitable access to assisted reproduction BMJ (IF 105.7) Pub Date : 2024-04-26 Silke J Dyer, G David Adamson, Marcia C Inhorn, Fernando Zegers-Hochschild
Equitable access to fertility care must be recognised as a human right so that it can be better balanced with other societal needs, say Silke Dyer , David Adamson , Marcia Inhorn, and Fernando Zegers-Hochschild Infertility affects one in six people in their lifetime yet remains a neglected global health problem.1 The World Health Organization (WHO) recognises infertility as a disease and has highlighted
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The Public Good on the Docket — The Supreme Court’s Evolving Approach to Public Health N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Joshua M. Sharfstein, and Lawrence O. Gostin From the Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore (J.M.S.), and the O’Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC (L.O.G.).
The Supreme Court has imposed new legal principles that impede the ability of states, Congress, and agencies to use evidence to protect the public. It now has the opportunity to reconsider this app...
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Reproductive rights in the United States: acquiescence is not a strategy Nat. Med. (IF 82.9) Pub Date : 2024-04-25 Laura J. Esserman, Douglas Yee
Scientific and medical conferences should not be held in states that ban abortion, as such bans put the lives of women at risk.
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Large language models for preventing medication direction errors in online pharmacies Nat. Med. (IF 82.9) Pub Date : 2024-04-25 Cristobal Pais, Jianfeng Liu, Robert Voigt, Vin Gupta, Elizabeth Wade, Mohsen Bayati
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Urgent action is needed to confront artemisinin partial resistance in African malaria parasites Nat. Med. (IF 82.9) Pub Date : 2024-04-25
Discover the world’s best science and medicine | Nature.com
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Welcoming the Era of Gene Editing in Medicine N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 George Q. Daley From Boston Children’s Hospital and Harvard Medical School — both in Boston.
Recent approvals of exa-cel for treatment of sickle cell disease and transfusion-dependent β-thalassemia mark the dawn of the era of gene editing in medicine. But ensuring access will be challenging.
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Extending Gene Medicines to All in Need N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Joseph M. McCune, and Hans-Peter Kiem From the Global Health Division, Bill and Melinda Gates Foundation (J.M.M.), and the Fred Hutchinson Cancer Center and University of Washington School of Medicine (H.-P.K.) — all in Seattle.
Sixty years ago, Fessas and Stamatoyannopoulos noticed that patients with hereditary persistence of fetal hemoglobin have a milder course of β-thalassemia than other patients with the condition.1 L...
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Specificity of CRISPR-Cas9 Editing in Exagamglogene Autotemcel N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Angela Yen, Zachary Zappala, Rebecca S. Fine, and Timothy D. Majarian Vertex Pharmaceuticals, Boston, MA, Parin Sripakdeevong CRISPR Therapeutics, Boston, MA, David Altshuler Vertex Pharmaceuticals, Boston, MA
The autologous cellular therapy exagamglogene autotemcel is generated by editing an erythroid-specific enhancer of BCL11A. Could another site be edited unintentionally? This study gauged the likeli...
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Exagamglogene Autotemcel for Severe Sickle Cell Disease N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Haydar Frangoul, Franco Locatelli, Akshay Sharma, Monica Bhatia, Markus Mapara, Lyndsay Molinari, Donna Wall, Robert I. Liem, Paul Telfer, Ami J. Shah, Marina Cavazzana, Selim Corbacioglu, Damiano Rondelli, Roland Meisel, Laurence Dedeken, Stephan Lobitz, Mariane de Montalembert, Martin H. Steinberg, Mark C. Walters, Michael J. Eckrich, Suzan Imren, Laura Bower, Christopher Simard, Weiyu Zhou, Fengjuan
Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis by means of ex vivo clustered regularly interspaced short palindromic repeats (CRISPR...
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Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Franco Locatelli, Peter Lang, Donna Wall, Roland Meisel, Selim Corbacioglu, Amanda M. Li, Josu de la Fuente, Ami J. Shah, Ben Carpenter, Janet L. Kwiatkowski, Markus Mapara, Robert I. Liem, Maria Domenica Cappellini, Mattia Algeri, Antonis Kattamis, Sujit Sheth, Stephan Grupp, Rupert Handgretinger, Puja Kohli, Daoyuan Shi, Leorah Ross, Yael Bobruff, Christopher Simard, Lanju Zhang, Phuong Khanh Morrow
Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis through ex vivo clustered regularly interspaced short palindromic repeats (CRISPR)–Ca...
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Age-Related Hearing Loss N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Patrick G. O’Malley, Frank R. Lin From the Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore.
Hearing progressively declines with age, manifesting initially as difficulty understanding speech in background noise and detrimentally affecting social functioning. Strategies and technologies can...
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CAR T-Cells and Safety Signals N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25
This podcast episode examines CAR T-cell therapy’s early successes, broader promise, and emerging risks, as the FDA considers reports of occasional secondary cancers.
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Case 13-2024: A 27-Year-Old Man with Leg Weakness N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, and Tara Corpuz, Andrew S. Allegretti, Cynthia L. Czawlytko, Nikolaos Stathatos, and Peter M. Sadow From the Departments of Medicine (A.S.A., N.S.), Radiology (C.L.C.), and Pathology (P.M.S.), Massachusetts General Hospital, and the Departments of Medicine
A 27-year-old man presented with weight loss, diarrhea, tremor, and proximal muscle weakness. The blood level of potassium was 1.8 mmol per liter. A diagnosis was made.
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Drug-Induced Oxidative Hemolysis N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Wing Kit Lam, and Sze Fai Yip Tuen Mun Hospital, Hong Kong, China
A 57-year-old woman presented with a 3-day history of shortness of breath and dizziness. Laboratory studies showed severe anemia with hemolysis, along with cellular abnormalities in peripheral blood.
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CAR as Booster to Launch Allogeneic Transplantation in Refractory Leukemia N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Didier Blaise From the Department of Hematology, Transplant and Cellular Immunotherapy Program, Institut Paoli Calmettes, Management Sport Cancer laboratory, Aix-Marseille University, Marseille, France.
Chimeric antigen receptor (CAR) T-cell therapies have revolutionized the treatment landscape for patients with relapsed or refractory B-cell lymphoid cancers.1 With studies showing that more than 5...
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China's Moon atlas is the most detailed ever made Nature (IF 64.8) Pub Date : 2024-04-25
The Geologic Atlas of the Lunar Globe doubles the resolution of Apollo-era maps and will support the space ambitions of China and other countries.
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‘Shut up and calculate’: how Einstein lost the battle to explain quantum reality Nature (IF 64.8) Pub Date : 2024-04-25
By suppressing questions they considered too ‘philosophical’, post-war physicists created an unquestioning orthodoxy that influences science to this day.
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Algorithm ranks peer reviewers by reputation — but critics warn of bias Nature (IF 64.8) Pub Date : 2024-04-25
There are questions about whether the tool, which could be used by editors to find and shortlist peer reviewers, would disadvantage inexperienced candidates or those in certain locations.
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NATO is boosting AI and climate research as scientific diplomacy remains on ice Nature (IF 64.8) Pub Date : 2024-04-25
As the military alliance created to counter the Soviet Union expands, it is prioritizing studies on how climate change affects security, cyber attacks and election interference.
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Are robots the solution to the crisis in older-person care? Nature (IF 64.8) Pub Date : 2024-04-25
Social robots that promise companionship and stimulation for older people and those with dementia are attracting investment, but some question their benefits.
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Structures of human γδ T cell receptor–CD3 complex Nature (IF 64.8) Pub Date : 2024-04-24 Weizhi Xin, Bangdong Huang, Ximin Chi, Yuehua Liu, Mengjiao Xu, Yuanyuan Zhang, Xu Li, Qiang Su, Qiang Zhou
Gamma delta (γδ) T cells, a unique T cell subgroup, are crucial in various immune responses and immunopathology1-3. The γδ T cell receptor (TCR), generated by γδ T cells, recognizes a diverse range of antigens independently of the major histocompatibility complex2. The γδ TCR associates with CD3 subunits, initiating T cell activation and holding great potential in immunotherapy4. Here, we report the
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How gliding marsupials got their ‘wings’ Nature (IF 64.8) Pub Date : 2024-04-24
Hear the biggest stories from the world of science | 24 April 2024
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Should the Maldives be creating new land? Nature (IF 64.8) Pub Date : 2024-04-24
The Maldives are racing to reclaim vast amounts of land to combat rising sea levels. But many are concerned that these efforts risk harming the paradise they aims to protect
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This giant extinct salmon had tusks like a warthog Nature (IF 64.8) Pub Date : 2024-04-24
Scientists initially thought that the outsized teeth were fangs, giving rise to the ‘sabre-toothed salmon’ nickname.
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High-performance fibre battery with polymer gel electrolyte Nature (IF 64.8) Pub Date : 2024-04-24 Chenhao Lu, Haibo Jiang, Xiangran Cheng, Jiqing He, Yao Long, Yingfan Chang, Xiaocheng Gong, Kun Zhang, Jiaxin Li, Zhengfeng Zhu, Jingxia Wu, Jiajia Wang, Yuanyuan Zheng, Xiang Shi, Lei Ye, Meng Liao, Xuemei Sun, Bingjie Wang, Peining Chen, Yonggang Wang, Huisheng Peng
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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers Nature (IF 64.8) Pub Date : 2024-04-24 Stephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler, Rita Andraos-Rey, Stephanie Barbe, Elisabeth Bechter, Jutta Blank, Vincent Bordas, Ernesta Dammassa, Andrea Decker, Noemi Di Nanni, Marion Dourdoigne, Elena Gavioli, Marc Hattenberger, Alisa Heuser, Christelle Hemmerlin, Jürgen Hinrichs, Grainne Kerr, Laurent Laborde, Isabel Jaco, Eloísa Jiménez Núñez, Hans-Joerg Martus, Cornelia
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Antisense oligonucleotide therapeutic approach for Timothy syndrome Nature (IF 64.8) Pub Date : 2024-04-24 Xiaoyu Chen, Fikri Birey, Min-Yin Li, Omer Revah, Rebecca Levy, Mayuri Vijay Thete, Noah Reis, Konstantin Kaganovsky, Massimo Onesto, Noriaki Sakai, Zuzana Hudacova, Jin Hao, Xiangling Meng, Seiji Nishino, John Huguenard, Sergiu P. Pașca
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Multi-project wafers for flexible thin-film electronics by independent foundries Nature (IF 64.8) Pub Date : 2024-04-24 Hikmet Çeliker, Wim Dehaene, Kris Myny
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Growth of diamond in liquid metal at 1 atm pressure Nature (IF 64.8) Pub Date : 2024-04-24 Yan Gong, Da Luo, Myeonggi Choe, Yongchul Kim, Babu Ram, Mohammad Zafari, Won Kyung Seong, Pavel Bakharev, Meihui Wang, In Kee Park, Seulyi Lee, Tae Joo Shin, Zonghoon Lee, Geunsik Lee, Rodney S. Ruoff
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PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells Nature (IF 64.8) Pub Date : 2024-04-24 Sebastian B. Lacher, Janina Dörr, Gustavo P. de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J. Rudolph, Nadine Spranger, Matteo Morotti, Alizee J. Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H. Busch, Veit R. Buchholz
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Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19 N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25
To the Editor: Cao et al. (Jan. 18 issue)1 evaluated changes in log10 copies of SARS-CoV-2 RNA per milliliter in adults with mild-to-moderate Covid-19 receiving simnotrelvir or placebo. However, on...
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A high-density and high-confinement tokamak plasma regime for fusion energy Nature (IF 64.8) Pub Date : 2024-04-24 S. Ding, A. M. Garofalo, H. Q. Wang, D. B. Weisberg, Z. Y. Li, X. Jian, D. Eldon, B. S. Victor, A. Marinoni, Q. M. Hu, I. S. Carvalho, T. Odstrčil, L. Wang, A. W. Hyatt, T. H. Osborne, X. Z. Gong, J. P. Qian, J. Huang, J. McClenaghan, C. T. Holcomb, J. M. Hanson
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Single-cell analysis reveals context-dependent, cell-level selection of mtDNA Nature (IF 64.8) Pub Date : 2024-04-24 Anna V. Kotrys, Timothy J. Durham, Xiaoyan A. Guo, Venkata R. Vantaku, Sareh Parangi, Vamsi K. Mootha
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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase Nature (IF 64.8) Pub Date : 2024-04-24 Kristen A. Baltgalvis, Kelsey N. Lamb, Kent T. Symons, Chu-Chiao Wu, Melissa A. Hoffman, Aaron N. Snead, Xiaodan Song, Thomas Glaza, Shota Kikuchi, Jason C. Green, Donald C. Rogness, Betty Lam, Maria E. Rodriguez-Aguirre, David R. Woody, Christie L. Eissler, Socorro Rodiles, Seth M. Negron, Steffen M. Bernard, Eileen Tran, Jonathan Pollock, Ali Tabatabaei, Victor Contreras, Heather N. Williams, Martha
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A magnetar giant flare in the nearby starburst galaxy M82 Nature (IF 64.8) Pub Date : 2024-04-24 Sandro Mereghetti, Michela Rigoselli, Ruben Salvaterra, Dominik Patryk Pacholski, James Craig Rodi, Diego Gotz, Edoardo Arrigoni, Paolo D’Avanzo, Christophe Adami, Angela Bazzano, Enrico Bozzo, Riccardo Brivio, Sergio Campana, Enrico Cappellaro, Jerome Chenevez, Fiore De Luise, Lorenzo Ducci, Paolo Esposito, Carlo Ferrigno, Matteo Ferro, Gian Luca Israel, Emeric Le Floc’h, Antonio Martin-Carrillo,
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Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25
To the Editor: Baris Feldman et al. (Nov. 2 issue)1 describe two siblings with biallelic loss-of-function (Met229Aspfs*16) variants in CORIN and hypertension, atrial fibrillation, atrial fibrosis, ...
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Whole-cortex in situ sequencing reveals input-dependent area identity Nature (IF 64.8) Pub Date : 2024-04-24 Xiaoyin Chen, Stephan Fischer, Mara C. P. Rue, Aixin Zhang, Didhiti Mukherjee, Patrick O. Kanold, Jesse Gillis, Anthony M. Zador
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Periportal macrophages protect against commensal-driven liver inflammation Nature (IF 64.8) Pub Date : 2024-04-24 Yu Miyamoto, Junichi Kikuta, Takahiro Matsui, Tetsuo Hasegawa, Kentaro Fujii, Daisuke Okuzaki, Yu-chen Liu, Takuya Yoshioka, Shigeto Seno, Daisuke Motooka, Yutaka Uchida, Erika Yamashita, Shogo Kobayashi, Hidetoshi Eguchi, Eiichi Morii, Karl Tryggvason, Takashi Shichita, Hisako Kayama, Koji Atarashi, Jun Kunisawa, Kenya Honda, Kiyoshi Takeda, Masaru Ishii
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Buprenorphine Dispensing after Elimination of the Waiver Requirement N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Kao-Ping Chua, Mark C. Bicket, and Amy S.B. Bohnert University of Michigan Medical School, Ann Arbor, MI, Rena M. Conti Boston University Questrom School of Business, Boston, MA, Pooja Lagisetty University of Michigan Medical School, Ann Arbor, MI, Thuy D. Nguyen University of Michigan School of Public Health, Ann Arbor, MI
In the year after the elimination of a waiver requirement to prescribe buprenorphine, the number of prescribers increased above the anticipated value, but the number of persons who received the dru...
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High carrier mobility along the [111] orientation in Cu2O photoelectrodes Nature (IF 64.8) Pub Date : 2024-04-24 Linfeng Pan, Linjie Dai, Oliver J. Burton, Lu Chen, Virgil Andrei, Youcheng Zhang, Dan Ren, Jinshui Cheng, Linxiao Wu, Kyle Frohna, Anna Abfalterer, Terry Chien-Jen Yang, Wenzhe Niu, Meng Xia, Stephan Hofmann, Paul J. Dyson, Erwin Reisner, Henning Sirringhaus, Jingshan Luo, Anders Hagfeldt, Michael Grätzel, Samuel D. Stranks