Letter to the Editor

Objective To review evidence from randomised trials assessing the effectiveness of strategies to deprescribe benzodiazepines and closely related sedative hypnotics (BSH). Design Systematic review and meta-analysis of randomised controlled trials. Data sources MEDLINE, Embase, CINAHL, PsycInfo, and CENTRAL, searched from inception to August 2024, and reference lists of included studies and similar systematic

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Letter to the Editor

New draconian police guidance reflects how outdated our abortion laws really are, says Sarah Salkeld As UK parliament prepares to vote on landmark reforms that would finally remove the threat of criminal investigation from women who end their own pregnancies, a directive from the National Police Chiefs’ Council (NPCC) is a stark illustration of what is at stake. Under the updated guidance on “child

Letter to the Editor

Letter to the Editor

After decades of pioneering institutional change in Chinese research, neuroscientist Rao Yi explains why US hesitation might offer China an opportunity to catch up internationally.

Genomic analyses of mother–father–fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants.

Julian Kirchherr craved a role with real-world impact. A career that straddles academia and management consultancy helped him to achieve his goal.

Research is revealing the cellular mechanisms that link mental well-being and longevity.

A toolkit outlines how academia can prevent various forms of misconduct.

Researchers in both countries are feeling the effects of a string of missile attacks exchanged between them.

Premenopausal women are more likely than men to develop certain cancers. Pathways activated by the sex hormone responsible could be targeted in cancer therapies.

Long (>200 nucleotides) non-coding RNAs (lncRNAs) play important roles in diverse aspects of life. Over 20 classes of lncRNAs have been identified in bacteria and bacteriophages through comparative genomics analyses, but their biological functions remain largely unexplored1-3. Due to the large sizes, the structural determinants of most lncRNAs also remain uncharacterized. Here we report the structures

Models suggest that human-caused global warming would have been detectable in the nineteenth century with today’s know-how.

The decision means that the US biomedical agency has to restore funding to hundreds of research projects, but the government will likely appeal.

Fifty countries have now ratified the UN High Seas Treaty, an agreement to put 30% of the ocean into protected areas. Plus, researchers have grown hearts containing human cells in pig embryos for the first time and the mysterious link between Earth’s magnetism and oxygen.

Simpson and colleagues’ article on widening access to medical school is the latest reminder of our education system’s (missed) opportunity to improve medical care by increasing the number of doctors from deprived backgrounds.1 Expanding diversity has established benefits to healthcare provision, specifically for those most in need. As a resident doctor from a deprived background, I agree that national

Unseen toll of conflicts on sexual and reproductive health and rights Women bear a disproportionate and often overlooked burden of war. In today’s conflict zones, women are not only deliberately targeted through gender based violence but also suffer intensely from the collapse of vital systems that support their health and wellbeing. The consequences for their sexual and reproductive health and rights

In our 2008 paper (Shankar, G. M. et al. Nat. Med. 14, 837–842; 2008), we moved beyond cellular and animal models to isolate pathogenic forms of amyloid-β directly from human brains and apply them to reproduce key features of AD: synaptic dysfunction, loss of dendritic spines, and impaired memory per se. We identified stable dimers of amyloid-β in Alzheimer’s cerebral cortex and their dose-dependent

### What you need to know A 73 year old man is brought to the emergency department following a ground level fall a few hours earlier. His physiological observations are normal, but he cannot remember any events for an hour preceding the fall. Examination reveals an occipital scalp haematoma, but no focal neurological deficit. His Glasgow coma scale (GCS) score is 15. His has a history of atrial fibrillation

Welfare cuts will hit the most deprived areas and the north of England hardest, with long term health and economic harms, write Clare Bambra and colleagues In her Spring Statement in March 2025, the UK Chancellor Rachel Reeves announced several changes to personal independence payments (PIP)—a non-means tested benefit to help with the additional costs of living with a disability or long term health

The NHS must reduce demand for healthcare with spending increases nearing their limits News reports that the NHS is one of the main beneficiaries of the spending review conceal some inconvenient truths. The uplift in budgets of around 3 per cent a year is welcome, but below the long term average of 3.6 per cent a year. It also requires the NHS to deliver implausible productivity improvements of 2 per

This interviewee rehabilitates illegally traded pangolins that fetch a high price on the black market.

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

Human cells injected into amniotic fluid find their way into fetal mouse organs.

Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach.

The first US woman to fly in space said little about her personal life in public. A candid film discloses the pressures she endured.

A competition to develop computational approaches to detect ‘novelty’ in published papers will help metascientists to study how out-of-the-box research changes the scientific landscape.

Each person’s breathing pattern could be used to identify them, or reveal their physical or mental characteristics. Plus, rings of bubbles might be a humpback whale’s attempt to communicate with us and who RFK Jr has appointed to his new vaccine panel.

We strongly agree with Byworth and colleagues that any reorganisation of the NHS must strengthen public health.1 The NHS has a budget of around £192bn, and there is little performance measurement of how population outcomes are impacted by this investment. Using expert public health input to help reduce health inequalities through the actions of health and care services is an important addition to the

In the age of telemedicine, house calls remain a vital part of primary care—and are in fact on the rise. Indira Subramanian reports House calls might seem to be a relic of the past, but they are thriving in an age where virtual care is a buzzword. Medicaid data show that spending on home and community based services increased from 1% of total Medicaid expenditure on long term services and supports

Decriminalisation needed to protect women from persecution Correspondence to: J Lord j.lord@exeter.ac.uk Abortion is still a criminal offence in England and Wales, with access to abortion permitted under specific circumstances defined in the Abortion Act 1967. One of us (Nicola Packer) was recently acquitted after standing trial in England having been accused of an illegal abortion.1 The high profile

Getting your introduction right can make a real difference, Elisabeth Mahase hears Anna Harvey Bluemel, academic clinical fellow in obstetrics and gynaecology, says, “Understanding names, roles, and levels of training in medicine are important—both to resident doctors, who represent a wide range of experience across all specialties, and to patients. The complexities of medical hierarchies and changes

In this Viewpoint, former members of the Advisory Committee on Immunization Practices (ACIP) caution that the sudden change in the ACIP may reverse the achievements of US immunization policy, including impeding access to lifesaving vaccines and putting US families at risk of dangerous and preventable illnesses.

This Viewpoint discusses a recent FDA-commissioned joint clinical practice guideline to help clinicians decide when and how to reduce or discontinue benzodiazepine prescriptions in a way that supports patient safety and optimal outcomes.

This Viewpoint discusses the US Centers for Disease Control and Prevention’s Healthcare Infection Control Practices Advisory Committee and how its termination could affect infection prevention standards in the future.

Importance Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD). Objective To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes. Design, Setting, and Participants Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample of 6514

This JAMA Guide to Statistics and Methods explains tipping point analysis, which assesses how a range of hypothetical patterns in missing outcome data in a randomized clinical trial (RCT) would affect the study’s conclusions, and examines its use in an RCT of treatment for hypertension.

ImportanceAdrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal insufficiency is common.ObservationsPrimary adrenal insufficiency, which involves deficiency of all adrenocortical hormones

ImportanceMortality of American Indian and Alaska Native (AI/AN) persons is known to be high but may be underreported in routine vital statistics.ObjectiveTo estimate age-specific mortality rates and life expectancy for non-Hispanic AI/AN individuals and other racial and ethnic groups, using self-identified race and ethnicity data in a national cohort, circumventing errors due to racial misclassification

BACKGROUND An interim analysis of progression-free survival in this trial showed that ibrutinib-venetoclax was superior to fludarabine-cyclophosphamide-rituximab (FCR) among patients with chronic lymphocytic leukemia (CLL). Whether ibrutinib-venetoclax is more effective than ibrutinib alone is unclear. METHODS In this phase 3, multicenter, open-label trial, we randomly assigned patients with CLL to

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Trafficking of scales for traditional medicine plays a relatively small part in the hunting of pangolins in Nigeria.

Earth’s magnetic field seems to correlate with conditions that helped complex life to thrive — a discovery that could aid the search for life on distant exoplanets.

Managing stocks of pharmaceutical products is a difficult business, for both hospitals and community pharmacies. In the 1950s the Japanese car manufacturers Toyota introduced a just-in-time system, by which only enough cars were manufactured at any time to satisfy actual or expected demand. In doing so they reduced stocks to near zero, thus reducing costs. Since then, just-in-time systems have been

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