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VV116 versus Nirmatrelvir–Ritonavir for Oral Treatment of Covid-19 N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-28 Zhujun Cao, Weiyi Gao, Hong Bao, Haiyan Feng, Shuya Mei, Peizhan Chen, Yueqiu Gao, Zhilei Cui, Qin Zhang, Xianmin Meng, Honglian Gui, Weijing Wang, Yimei Jiang, Zijia Song, Yiqing Shi, Jing Sun, Yifei Zhang, Qing Xie, Yiping Xu, Guang Ning, Yuan Gao, Ren Zhao
Background Nirmatrelvir–ritonavir has been authorized for emergency use by many countries for the treatment of coronavirus disease 2019 (Covid-19). However, the supply falls short of the global demand, which creates a need for more options. VV116 is an oral antiviral agent with potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We conducted a phase 3, noninferiority
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Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-21 Rona Yaeger, Jared Weiss, Meredith S. Pelster, Alexander I. Spira, Minal Barve, Sai-Hong I. Ou, Ticiana A. Leal, Tanios S. Bekaii-Saab, Cloud P. Paweletz, Grace A. Heavey, James G. Christensen, Karen Velastegui, Thian Kheoh, Hirak Der-Torossian, Samuel J. Klempner
New England Journal of Medicine, Ahead of Print.
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Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-21 John H. Strickler, Hironaga Satake, Thomas J. George, Rona Yaeger, Antoine Hollebecque, Ignacio Garrido-Laguna, Martin Schuler, Timothy F. Burns, Andrew L. Coveler, Gerald S. Falchook, Mark Vincent, Yu Sunakawa, Laetitia Dahan, David Bajor, Sun-Young Rha, Charlotte Lemech, Dejan Juric, Marko Rehn, Gataree Ngarmchamnanrith, Pegah Jafarinasabian, Qui Tran, David S. Hong
New England Journal of Medicine, Ahead of Print.
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Recombinant ADAMTS13 for Hereditary Thrombotic Thrombocytopenic Purpura N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-22 Lars M. Asmis, Andreas Serra, Alexander Krafft, Abraham Licht, Elke Leisinger, Jana Henschkowski-Serra, Michael T. Ganter, Steffen Hauptmann, Marianne Tinguely, Johanna A. Kremer Hovinga
New England Journal of Medicine, Volume 387, Issue 25, Page 2356-2361, December 2022.
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Lentiviral Gene Therapy for Artemis-Deficient SCID N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-22 Morton J. Cowan, Jason Yu, Janelle Facchino, Carol Fraser-Browne, Ukina Sanford, Misako Kawahara, Jasmeen Dara, Janel Long-Boyle, Jess Oh, Wendy Chan, Shivali Chag, Lori Broderick, Deepak Chellapandian, Hélène Decaluwe, Catherine Golski, Diana Hu, Caroline Y. Kuo, Holly K. Miller, Aleksandra Petrovic, Robert Currier, Joan F. Hilton, Divya Punwani, Christopher C. Dvorak, Harry L. Malech, R. Scott McIvor
New England Journal of Medicine, Volume 387, Issue 25, Page 2344-2355, December 2022.
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Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-22 Evan S. Dellon, Marc E. Rothenberg, Margaret H. Collins, Ikuo Hirano, Mirna Chehade, Albert J. Bredenoord, Alfredo J. Lucendo, Jonathan M. Spergel, Seema Aceves, Xian Sun, Matthew P. Kosloski, Mohamed A. Kamal, Jennifer D. Hamilton, Bethany Beazley, Eilish McCann, Kiran Patel, Leda P. Mannent, Elizabeth Laws, Bolanle Akinlade, Nikhil Amin, Wei Keat Lim, Matthew F. Wipperman, Marcella Ruddy, Naimish
New England Journal of Medicine, Volume 387, Issue 25, Page 2317-2330, December 2022.
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Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-14 Areef Ishani, William C. Cushman, Sarah M. Leatherman, Robert A. Lew, Patricia Woods, Peter A. Glassman, Addison A. Taylor, Cynthia Hau, Alison Klint, Grant D. Huang, Mary T. Brophy, Louis D. Fiore, Ryan E. Ferguson
New England Journal of Medicine, Ahead of Print.
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Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-14 David Pellerin, Matt C. Danzi, Carlo Wilke, Mathilde Renaud, Sarah Fazal, Marie-Josée Dicaire, Carolin K. Scriba, Catherine Ashton, Christopher Yanick, Danique Beijer, Adriana Rebelo, Clarissa Rocca, Zane Jaunmuktane, Joshua A. Sonnen, Roxanne Larivière, David Genís, Laura Molina Porcel, Karine Choquet, Rawan Sakalla, Sylvie Provost, Rebecca Robertson, Xavier Allard-Chamard, Martine Tétreault, Sarah
New England Journal of Medicine, Ahead of Print.
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Randomized Trial of Vaccines for Zaire Ebola Virus Disease N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-14 PREVAC Study Team
Background Questions remain concerning the rapidity of immune responses and the durability and safety of vaccines used to prevent Zaire Ebola virus disease. Methods We conducted two randomized, placebo-controlled trials — one involving adults and one involving children — to evaluate the safety and immune responses of three vaccine regimens against Zaire Ebola virus disease: Ad26.ZEBOV followed by MVA-BN-Filo
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Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-13 Jennifer R. Brown, Barbara Eichhorst, Peter Hillmen, Wojciech Jurczak, Maciej Kaźmierczak, Nicole Lamanna, Susan M. O’Brien, Constantine S. Tam, Lugui Qiu, Keshu Zhou, Martin Simkovic, Jiri Mayer, Amanda Gillespie-Twardy, Alessandra Ferrajoli, Peter S. Ganly, Robert Weinkove, Sebastian Grosicki, Andrzej Mital, Tadeusz Robak, Anders Osterborg, Habte A. Yimer, Tommi Salmi, Megan-Der-Yu Wang, Lina Fu
New England Journal of Medicine, Ahead of Print.
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Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-11 Michael J. Dickinson, Carmelo Carlo-Stella, Franck Morschhauser, Emmanuel Bachy, Paolo Corradini, Gloria Iacoboni, Cyrus Khan, Tomasz Wróbel, Fritz Offner, Marek Trněný, Shang-Ju Wu, Guillaume Cartron, Mark Hertzberg, Anna Sureda, David Perez-Callejo, Linda Lundberg, James Relf, Mark Dixon, Emma Clark, Kathryn Humphrey, Martin Hutchings
New England Journal of Medicine, Ahead of Print.
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Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-08 Jonas Hugosson, Marianne Månsson, Jonas Wallström, Ulrika Axcrona, Sigrid V. Carlsson, Lars Egevad, Kjell Geterud, Ali Khatami, Kimia Kohestani, Carl-Gustaf Pihl, Andreas Socratous, Johan Stranne, Rebecka Arnsrud Godtman, Mikael Hellström
New England Journal of Medicine, Volume 387, Issue 23, Page 2126-2137, December 2022.
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Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-08 Maartje W. Rohaan, Troels H. Borch, Joost H. van den Berg, Özcan Met, Rob Kessels, Marnix H. Geukes Foppen, Joachim Stoltenborg Granhøj, Bastiaan Nuijen, Cynthia Nijenhuis, Inge Jedema, Maaike van Zon, Saskia Scheij, Jos H. Beijnen, Marten Hansen, Carlijn Voermans, Inge M. Noringriis, Tine J. Monberg, Rikke B. Holmstroem, Lidwina D.V. Wever, Marloes van Dijk, Lindsay G. Grijpink-Ongering, Ludy H.M
New England Journal of Medicine, Volume 387, Issue 23, Page 2113-2125, December 2022.
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Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-06 Tim Hundscheid, Wes Onland, Elisabeth M.W. Kooi, Daniel C. Vijlbrief, Willem B. de Vries, Koen P. Dijkman, Anton H. van Kaam, Eduardo Villamor, André A. Kroon, Remco Visser, Susanne M. Mulder-de Tollenaer, Barbara De Bisschop, Peter H. Dijk, Daniela Avino, Catheline Hocq, Alexandra Zecic, Marisse Meeus, Tessa de Baat, Frank Derriks, Tine B. Henriksen, Kasper J. Kyng, Rogier Donders, Debbie H.G.M. Nuytemans
New England Journal of Medicine, Ahead of Print.
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Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy N. Engl. J. Med. (IF 176.079) Pub Date : 2022-12-01 Elizabeth A. Suarez, Krista F. Huybrechts, Loreen Straub, Sonia Hernández-Díaz, Hendrée E. Jones, Hilary S. Connery, Jonathan M. Davis, Kathryn J. Gray, Barry Lester, Mishka Terplan, Helen Mogun, Brian T. Bateman
New England Journal of Medicine, Volume 387, Issue 22, Page 2033-2044, December 2022.
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Lecanemab in Early Alzheimer’s Disease N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-30 Christopher H. van Dyck, Chad J. Swanson, Paul Aisen, Randall J. Bateman, Christopher Chen, Michelle Gee, Michio Kanekiyo, David Li, Larisa Reyderman, Sharon Cohen, Lutz Froelich, Sadao Katayama, Marwan Sabbagh, Bruno Vellas, David Watson, Shobha Dhadda, Michael Irizarry, Lynn D. Kramer, Takeshi Iwatsubo
New England Journal of Medicine, Ahead of Print.
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Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-09 Tori L. Cowger, Eleanor J. Murray, Jaylen Clarke, Mary T. Bassett, Bisola O. Ojikutu, Sarimer M. Sánchez, Natalia Linos, Kathryn T. Hall
Background In February 2022, Massachusetts rescinded a statewide universal masking policy in public schools, and many Massachusetts school districts lifted masking requirements during the subsequent weeks. In the greater Boston area, only two school districts — the Boston and neighboring Chelsea districts — sustained masking requirements through June 2022. The staggered lifting of masking requirements
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In Utero Enzyme-Replacement Therapy for Infantile-Onset Pompe’s Disease N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-09 Jennifer L. Cohen, Pranesh Chakraborty, Karen Fung-Kee-Fung, Marisa E. Schwab, Deeksha Bali, Sarah P. Young, Michael H. Gelb, Hamid Khaledi, Alicia DiBattista, Stacey Smallshaw, Felipe Moretti, Derek Wong, Catherine Lacroix, Dina El Demellawy, Kyle C. Strickland, Jane Lougheed, Anita Moon-Grady, Billie R. Lianoglou, Paul Harmatz, Priya S. Kishnani, Tippi C. MacKenzie
New England Journal of Medicine, Ahead of Print.
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Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-08 Man-Fung Yuen, Seng-Gee Lim, Robert Plesniak, Keiji Tsuji, Harry L.A. Janssen, Cristina Pojoga, Adrian Gadano, Corneliu P. Popescu, Tatyana Stepanova, Tarik Asselah, Gheorghe Diaconescu, Hyung Joon Yim, Jeong Heo, Ewa Janczewska, Alexander Wong, Nevin Idriz, Michio Imamura, Giuliano Rizzardini, Koichi Takaguchi, Pietro Andreone, Manuela Arbune, Jinlin Hou, Sung Jae Park, Andrei Vata, Jennifer Cremer
New England Journal of Medicine, Ahead of Print.
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Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-07 Mason W. Freeman, Yuan-Di Halvorsen, William Marshall, Mackenzie Pater, Jon Isaacsohn, Catherine Pearce, Brian Murphy, Nicholas Alp, Ajay Srivastava, Deepak L. Bhatt, Morris J. Brown
New England Journal of Medicine, Ahead of Print.
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Progression of Atrial Fibrillation after Cryoablation or Drug Therapy N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-07 Jason G. Andrade, Marc W. Deyell, Laurent Macle, George A. Wells, Matthew Bennett, Vidal Essebag, Jean Champagne, Jean-Francois Roux, Derek Yung, Allan Skanes, Yaariv Khaykin, Carlos Morillo, Umjeet Jolly, Paul Novak, Evan Lockwood, Guy Amit, Paul Angaran, John Sapp, Stephan Wardell, Sandra Lauck, Julia Cadrin-Tourigny, Simon Kochhäuser, Atul Verma
New England Journal of Medicine, Ahead of Print.
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Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-07 Alik Farber, Matthew T. Menard, Michael S. Conte, John A. Kaufman, Richard J. Powell, Niteesh K. Choudhry, Taye H. Hamza, Susan F. Assmann, Mark A. Creager, Mark J. Cziraky, Michael D. Dake, Michael R. Jaff, Diane Reid, Flora S. Siami, George Sopko, Christopher J. White, Max van Over, Michael B. Strong, Maria F. Villarreal, Michelle McKean, Ezana Azene, Amir Azarbal, Andrew Barleben, David K. Chew
New England Journal of Medicine, Ahead of Print.
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Methylprednisolone for Heart Surgery in Infants — A Randomized, Controlled Trial N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-06 Kevin D. Hill, Prince J. Kannankeril, Jeffrey P. Jacobs, H. Scott Baldwin, Marshall L. Jacobs, Sean M. O’Brien, David P. Bichel, Eric M. Graham, Brian Blasiole, Ashraf Resheidat, Adil S. Husain, S. Ram Kumar, Jerry L. Kirchner, Dianne S. Gallup, Joseph W. Turek, Mark Bleiweis, Bret Mettler, Alexis Benscoter, Eric Wald, Tara Karamlou, Andrew H. Van Bergen, David Overman, Pirooz Eghtesady, Ryan Butts
New England Journal of Medicine, Ahead of Print.
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Duration of Device-Based Fever Prevention after Cardiac Arrest N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-06 Christian Hassager, Henrik Schmidt, Jacob E. Møller, Johannes Grand, Simon Mølstrøm, Rasmus P. Beske, Søren Boesgaard, Britt Borregaard, Ditte Bekker-Jensen, Jordi S. Dahl, Martin S. Frydland, Dan E. Høfsten, Yusuf A. Isse, Jakob Josiassen, Vibeke R. Lind Jørgensen, Daniel Kondziella, Matias G. Lindholm, Emil Moser, Benjamin C. Nyholm, Laust E.R. Obling, Laura Sarkisian, Frederik T. Søndergaard, Jakob
New England Journal of Medicine, Ahead of Print.
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Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-06 Michelle L. O’Donoghue, Robert S. Rosenson, Baris Gencer, J. Antonio G. López, Norman E. Lepor, Seth J. Baum, Elmer Stout, Daniel Gaudet, Beat Knusel, Julia F. Kuder, Xinhui Ran, Sabina A. Murphy, Huei Wang, You Wu, Helina Kassahun, Marc S. Sabatine
New England Journal of Medicine, Ahead of Print.
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Defibrillation Strategies for Refractory Ventricular Fibrillation N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-06 Sheldon Cheskes, P. Richard Verbeek, Ian R. Drennan, Shelley L. McLeod, Linda Turner, Ruxandra Pinto, Michael Feldman, Matthew Davis, Christian Vaillancourt, Laurie J. Morrison, Paul Dorian, Damon C. Scales
New England Journal of Medicine, Ahead of Print.
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Trial of an Intervention to Improve Acute Heart Failure Outcomes N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-05 Douglas S. Lee, Sharon E. Straus, Michael E. Farkouh, Peter C. Austin, Monica Taljaard, Alice Chong, Christine Fahim, Stephanie Poon, Peter Cram, Stuart Smith, Robert S. McKelvie, Liane Porepa, Michael Hartleib, Peter Mitoff, Robert M. Iwanochko, Andrea MacDougall, Steven Shadowitz, Howard Abrams, Esam Elbarasi, Jiming Fang, Jacob A. Udell, Michael J. Schull, Susanna Mak, Heather J. Ross
New England Journal of Medicine, Ahead of Print.
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Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-05 Aruna Das Pradhan, Robert J. Glynn, Jean-Charles Fruchart, Jean G. MacFadyen, Elaine S. Zaharris, Brendan M. Everett, Stuart E. Campbell, Ryu Oshima, Pierre Amarenco, Dirk J. Blom, Eliot A. Brinton, Robert H. Eckel, Marshall B. Elam, João S. Felicio, Henry N. Ginsberg, Assen Goudev, Shun Ishibashi, Jacob Joseph, Tatsuhiko Kodama, Wolfgang Koenig, Lawrence A. Leiter, Alberto J. Lorenzatti, Boris Mankovsky
New England Journal of Medicine, Ahead of Print.
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Empagliflozin in Patients with Chronic Kidney Disease N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-04 The EMPA-KIDNEY Collaborative Group
New England Journal of Medicine, Ahead of Print.
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Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-03 Sunil Bhandari, Samir Mehta, Arif Khwaja, John G.F. Cleland, Natalie Ives, Elizabeth Brettell, Marie Chadburn, Paul Cockwell
New England Journal of Medicine, Ahead of Print.
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Covid-19 Vaccine Protection among Children and Adolescents in Qatar N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-02 Hiam Chemaitelly, Sawsan AlMukdad, Houssein H. Ayoub, Heba N. Altarawneh, Peter Coyle, Patrick Tang, Hadi M. Yassine, Hebah A. Al-Khatib, Maria K. Smatti, Mohammad R. Hasan, Zaina Al-Kanaani, Einas Al-Kuwari, Andrew Jeremijenko, Anvar H. Kaleeckal, Ali N. Latif, Riyazuddin M. Shaik, Hanan F. Abdul-Rahim, Gheyath K. Nasrallah, Mohamed G. Al-Kuwari, Hamad E. Al-Romaihi, Adeel A. Butt, Mohamed H. Al-Thani
Background The BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) has been authorized for use in children 5 to 11 years of age and adolescents 12 to 17 years of age but in different antigen doses. Methods We assessed the real-world effectiveness of the BNT162b2 vaccine against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children and adolescents in Qatar
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Once-Weekly Semaglutide in Adolescents with Obesity N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-02 Daniel Weghuber, Timothy Barrett, Margarita Barrientos-Pérez, Inge Gies, Dan Hesse, Ole K. Jeppesen, Aaron S. Kelly, Lucy D. Mastrandrea, Rasmus Sørrig, Silva Arslanian
New England Journal of Medicine, Ahead of Print.
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Early Amino Acids in Extremely Preterm Infants and Neurodisability at 2 Years N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-03 Frank H. Bloomfield, Yannan Jiang, Jane E. Harding, Caroline A. Crowther, Barbara E. Cormack
New England Journal of Medicine, Volume 387, Issue 18, Page 1661-1672, November 2022.
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Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin’s Lymphoma N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-03 Sharon M. Castellino, Qinglin Pei, Susan K. Parsons, David Hodgson, Kathleen McCarten, Terzah Horton, Steve Cho, Yue Wu, Angela Punnett, Hema Dave, Tara O. Henderson, Bradford S. Hoppe, Anne-Marie Charpentier, Frank G. Keller, Kara M. Kelly
New England Journal of Medicine, Volume 387, Issue 18, Page 1649-1660, November 2022.
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Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-03 Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Peter C. Arden, Annie Baker, James C. Bennett, Catherine Bird, Renske E. Blom, Christine Brennan, Donna Brusch, Lisa Burke, Kete Campbell-Coker, Robin Carhart-Harris, Joseph Cattell, Aster Daniel, Charles DeBattista, Boadie W. Dunlop, Katherine Eisen, David Feifel, MacKenzie Forbes, Hannah M. Haumann, David J. Hellerstein, Astrid I. Hoppe, Muhammad
New England Journal of Medicine, Volume 387, Issue 18, Page 1637-1648, November 2022.
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Safety and Efficacy of a Monoclonal Antibody against Malaria in Mali N. Engl. J. Med. (IF 176.079) Pub Date : 2022-11-01 Kassoum Kayentao, Aissata Ongoiba, Anne C. Preston, Sara A. Healy, Safiatou Doumbo, Didier Doumtabe, Abdrahamane Traore, Hamadi Traore, Adama Djiguiba, Shanping Li, Mary E. Peterson, Shinyi Telscher, Azza H. Idris, Neville K. Kisalu, Kevin Carlton, Leonid Serebryannyy, Sandeep Narpala, Adrian B. McDermott, Martin Gaudinski, Siriman Traore, Hamidou Cisse, Mamadou Keita, Jeff Skinner, Zonghui Hu, Amatigué
New England Journal of Medicine, Ahead of Print.
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Haloperidol for the Treatment of Delirium in ICU Patients N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-26 Nina C. Andersen-Ranberg, Lone M. Poulsen, Anders Perner, Jørn Wetterslev, Stine Estrup, Johanna Hästbacka, Matt Morgan, Giuseppe Citerio, Jesus Caballero, Theis Lange, Maj-Brit N. Kjær, Bjørn H. Ebdrup, Janus Engstrøm, Markus H. Olsen, Marie Oxenbøll Collet, Camilla B. Mortensen, Sven-Olaf Weber, A. Sofie Andreasen, Morten H. Bestle, Bülent Uslu, Helle Scharling Pedersen, Louise Gramstrup Nielsen
New England Journal of Medicine, Ahead of Print.
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Early Active Mobilization during Mechanical Ventilation in the ICU N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-26 The TEAM Study Investigators and the ANZICS Clinical Trials Group
New England Journal of Medicine, Ahead of Print.
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Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-26 Arnaud W. Thille, Arnaud Gacouin, Rémi Coudroy, Stephan Ehrmann, Jean-Pierre Quenot, Mai-Anh Nay, Christophe Guitton, Damien Contou, Guylaine Labro, Jean Reignier, Gael Pradel, Gaëtan Beduneau, Laurence Dangers, Clement Saccheri, Gwénaël Prat, Guillaume Lacave, Nicholas Sedillot, Nicolas Terzi, Béatrice La Combe, Jean-Paul Mira, Antoine Romen, Marie-Ange Azais, Anahita Rouzé, Jérôme Devaquet, Agathe
New England Journal of Medicine, Ahead of Print.
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Protection against Omicron from Vaccination and Previous Infection in a Prison System N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-26 Elizabeth T. Chin, David Leidner, Lauren Lamson, Kimberley Lucas, David M. Studdert, Jeremy D. Goldhaber-Fiebert, Jason R. Andrews, Joshua A. Salomon
Background Information regarding the protection conferred by vaccination and previous infection against infection with the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited. Methods We evaluated the protection conferred by mRNA vaccines and previous infection against infection with the omicron variant in two high-risk populations: residents and staff
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Neonatal Docosahexaenoic Acid in Preterm Infants and Intelligence at 5 Years N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-27 Jacqueline F. Gould, Maria Makrides, Robert A. Gibson, Thomas R. Sullivan, Andrew J. McPhee, Peter J. Anderson, Karen P. Best, Mary Sharp, Jeanie L.Y. Cheong, Gillian F. Opie, Javeed Travadi, Jana M. Bednarz, Peter G. Davis, Karen Simmer, Lex W. Doyle, Carmel T. Collins
New England Journal of Medicine, Volume 387, Issue 17, Page 1579-1588, October 2022.
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Racial and Ethnic Differences in Bystander CPR for Witnessed Cardiac Arrest N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-27 R. Angel Garcia, John A. Spertus, Saket Girotra, Brahmajee K. Nallamothu, Kevin F. Kennedy, Bryan F. McNally, Khadijah Breathett, Marina Del Rios, Comilla Sasson, Paul S. Chan
Background Differences in the incidence of cardiopulmonary resuscitation (CPR) provided by bystanders contribute to survival disparities among persons with out-of-hospital cardiac arrest. It is critical to understand whether the incidence of bystander CPR in witnessed out-of-hospital cardiac arrests at home and in public settings differs according to the race or ethnic group of the person with cardiac
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Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-24 Matthew W. Semler, Jonathan D. Casey, Bradley D. Lloyd, Pamela G. Hastings, Margaret A. Hays, Joanna L. Stollings, Kevin G. Buell, John H. Brems, Edward T. Qian, Kevin P. Seitz, Li Wang, Christopher J. Lindsell, Robert E. Freundlich, Jonathan P. Wanderer, Jin H. Han, Gordon R. Bernard, Wesley H. Self, Todd W. Rice
New England Journal of Medicine, Ahead of Print.
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Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-19 Evan J. Anderson, C. Buddy Creech, Vladimir Berthaud, Arin Piramzadian, Kimball A. Johnson, Marcus Zervos, Fredric Garner, Carl Griffin, Khozema Palanpurwala, Mark Turner, Jeffrey Gerber, Richard L. Bennett, Kashif Ali, Madhavi Ampajwala, Gary Berman, Jennifer Nayak, Carey Chronis, Barbara Rizzardi, William J. Muller, Christopher A. Smith, George Fuchs, Daniel Hsia, Joanne E. Tomassini, Dianne DeLucia
Background The safety, reactogenicity, immunogenicity, and efficacy of the mRNA-1273 coronavirus disease 2019 (Covid-19) vaccine in young children are unknown. Methods Part 1 of this ongoing phase 2–3 trial was open label for dose selection; part 2 was an observer-blinded, placebo-controlled evaluation of the selected dose. In part 2, we randomly assigned young children (6 months to 5 years of age)
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Two Phase 3, Randomized, Controlled Trials of Ruxolitinib Cream for Vitiligo N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-20 David Rosmarin, Thierry Passeron, Amit G. Pandya, Pearl Grimes, John E. Harris, Seemal R. Desai, Mark Lebwohl, Mireille Ruer-Mulard, Julien Seneschal, Albert Wolkerstorfer, Deanna Kornacki, Kang Sun, Kathleen Butler, Khaled Ezzedine
New England Journal of Medicine, Volume 387, Issue 16, Page 1445-1455, October 2022.
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Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-13 Rebecca D. Ganetzky, Andrew L. Markhard, Irene Yee, Sheila Clever, Alan Cahill, Hardik Shah, Zenon Grabarek, Tsz-Leung To, Vamsi K. Mootha
New England Journal of Medicine, Volume 387, Issue 15, Page 1395-1403, October 2022.
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Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-13 Tudor G. Jovin, Chuanhui Li, Longfei Wu, Chuanjie Wu, Jian Chen, Changchun Jiang, Zhonghua Shi, Zongen Gao, Cunfeng Song, Wenhuo Chen, Ya Peng, Chen Yao, Ming Wei, Tong Li, Liping Wei, Guodong Xiao, Hua Yang, Ming Ren, Jiangang Duan, Xinfeng Liu, Qingwu Yang, Yuxiu Liu, Qingfeng Zhu, Wanchao Shi, Qiyi Zhu, Xiaobo Li, Zaiyu Guo, Qi Yang, Chengbei Hou, Wenbo Zhao, Qingfeng Ma, Yunzhou Zhang, Liqun Jiao
New England Journal of Medicine, Volume 387, Issue 15, Page 1373-1384, October 2022.
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Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-13 Chunrong Tao, Raul G. Nogueira, Yuyou Zhu, Jun Sun, Hongxing Han, Guangxiong Yuan, Changming Wen, Peiyang Zhou, Wenhuo Chen, Guoyong Zeng, Yuwen Li, Zhengfei Ma, Chuanqing Yu, Junfeng Su, Zhiming Zhou, Zhongjun Chen, Geng Liao, Yaxuan Sun, Youquan Ren, Hui Zhang, Jie Chen, Xincan Yue, Guodong Xiao, Li Wang, Rui Liu, Wenhua Liu, Yong Liu, Li Wang, Chao Zhang, Tianlong Liu, Jianlong Song, Rui Li, Pengfei
New England Journal of Medicine, Volume 387, Issue 15, Page 1361-1372, October 2022.
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Liquefied Petroleum Gas or Biomass for Cooking and Effects on Birth Weight N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-10 Thomas F. Clasen, Howard H. Chang, Lisa M. Thompson, Miles A. Kirby, Kalpana Balakrishnan, Anaité Díaz-Artiga, John P. McCracken, Ghislaine Rosa, Kyle Steenland, Ashley Younger, Vigneswari Aravindalochanan, Dana B. Barr, Adly Castañaza, Yunyun Chen, Marilú Chiang, Maggie L. Clark, Sarada Garg, Stella Hartinger, Shirin Jabbarzadeh, Michael A. Johnson, Dong-Yun Kim, Amy E. Lovvorn, Eric D. McCollum,
New England Journal of Medicine, Ahead of Print.
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Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-09 Michael Bretthauer, Magnus Løberg, Paulina Wieszczy, Mette Kalager, Louise Emilsson, Kjetil Garborg, Maciej Rupinski, Evelien Dekker, Manon Spaander, Marek Bugajski, Øyvind Holme, Ann G. Zauber, Nastazja D. Pilonis, Andrzej Mroz, Ernst J. Kuipers, Joy Shi, Miguel A. Hernán, Hans-Olov Adami, Jaroslaw Regula, Geir Hoff, Michal F. Kaminski
New England Journal of Medicine, Ahead of Print.
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Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-05 Lalantha Leelarathna, Mark L. Evans, Sankalpa Neupane, Gerry Rayman, Sarah Lumley, Iain Cranston, Parth Narendran, Katharine Barnard-Kelly, Christopher J. Sutton, Rachel A. Elliott, Vicky P. Taxiarchi, Georgios Gkountouras, Matthew Burns, Womba Mubita, Naresh Kanumilli, Maisie Camm, Hood Thabit, Emma G. Wilmot
New England Journal of Medicine, Ahead of Print.
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Trial of Intravenous Immune Globulin in Dermatomyositis N. Engl. J. Med. (IF 176.079) Pub Date : 2022-10-06 Rohit Aggarwal, Christina Charles-Schoeman, Joachim Schessl, Zsuzsanna Bata-Csörgő, Mazen M. Dimachkie, Zoltan Griger, Sergey Moiseev, Chester Oddis, Elena Schiopu, Jiri Vencovský, Irene Beckmann, Elisabeth Clodi, Olga Bugrova, Katalin Dankó, Floranne Ernste, Namita A. Goyal, Marvin Heuer, Marie Hudson, Yessar M. Hussain, Chafic Karam, Nina Magnolo, Ronald Nelson, Nataliia Pozur, Liudmyla Prystupa
New England Journal of Medicine, Volume 387, Issue 14, Page 1264-1278, October 2022.
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GPRC5D-Targeted CAR T Cells for Myeloma N. Engl. J. Med. (IF 176.079) Pub Date : 2022-09-29 Sham Mailankody, Sean M. Devlin, Jonathan Landa, Karthik Nath, Claudia Diamonte, Elizabeth J. Carstens, Douglas Russo, Romany Auclair, Lisa Fitzgerald, Briana Cadzin, Xiuyan Wang, Devanjan Sikder, Brigitte Senechal, Vladimir P. Bermudez, Terence J. Purdon, Kinga Hosszu, Devin P. McAvoy, Tasmin Farzana, Elena Mead, Jessica A. Wilcox, Bianca D. Santomasso, Gunjan L. Shah, Urvi A. Shah, Neha Korde, Alexander
New England Journal of Medicine, Volume 387, Issue 13, Page 1196-1206, September 2022.
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Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes N. Engl. J. Med. (IF 176.079) Pub Date : 2022-09-29 Bionic Pancreas Research Group
New England Journal of Medicine, Volume 387, Issue 13, Page 1161-1172, September 2022.
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Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS N. Engl. J. Med. (IF 176.079) Pub Date : 2022-09-22 Timothy M. Miller, Merit E. Cudkowicz, Angela Genge, Pamela J. Shaw, Gen Sobue, Robert C. Bucelli, Adriano Chiò, Philip Van Damme, Albert C. Ludolph, Jonathan D. Glass, Jinsy A. Andrews, Suma Babu, Michael Benatar, Christopher J. McDermott, Thos Cochrane, Sowmya Chary, Sheena Chew, Han Zhu, Fan Wu, Ivan Nestorov, Danielle Graham, Peng Sun, Manjit McNeill, Laura Fanning, Toby A. Ferguson, Stephanie
New England Journal of Medicine, Volume 387, Issue 12, Page 1099-1110, September 2022.
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Glycemia Reduction in Type 2 Diabetes — Microvascular and Cardiovascular Outcomes N. Engl. J. Med. (IF 176.079) Pub Date : 2022-09-22 The GRADE Study Research Group
New England Journal of Medicine, Volume 387, Issue 12, Page 1075-1088, September 2022.
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Glycemia Reduction in Type 2 Diabetes — Glycemic Outcomes N. Engl. J. Med. (IF 176.079) Pub Date : 2022-09-22 The GRADE Study Research Group
New England Journal of Medicine, Volume 387, Issue 12, Page 1063-1074, September 2022.
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Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement N. Engl. J. Med. (IF 176.079) Pub Date : 2022-09-17 Samir R. Kapadia, Raj Makkar, Martin Leon, Mohamed Abdel-Wahab, Thomas Waggoner, Steffen Massberg, Wolfgang Rottbauer, Samuel Horr, Lars Sondergaard, Juhana Karha, Robert Gooley, Lowell Satler, Robert C. Stoler, Steven R. Messé, Suzanne J. Baron, Julia Seeger, Susheel Kodali, Amar Krishnaswamy, Vinod H. Thourani, Katherine Harrington, Stuart Pocock, Rodrigo Modolo, Dominic J. Allocco, Ian T. Meredith
New England Journal of Medicine, Ahead of Print.
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A Bivalent Omicron-Containing Booster Vaccine against Covid-19 N. Engl. J. Med. (IF 176.079) Pub Date : 2022-09-16 Spyros Chalkias, Charles Harper, Keith Vrbicky, Stephen R. Walsh, Brandon Essink, Adam Brosz, Nichole McGhee, Joanne E. Tomassini, Xing Chen, Ying Chang, Andrea Sutherland, David C. Montefiori, Bethany Girard, Darin K. Edwards, Jing Feng, Honghong Zhou, Lindsey R. Baden, Jacqueline M. Miller, Rituparna Das
Background The safety and immunogenicity of the bivalent omicron-containing mRNA-1273.214 booster vaccine are not known. Methods In this ongoing, phase 2–3 study, we compared the 50-μg bivalent vaccine mRNA-1273.214 (25 μg each of ancestral Wuhan-Hu-1 and omicron B.1.1.529 [BA.1] spike messenger RNAs) with the previously authorized 50-μg mRNA-1273 booster. We administered mRNA-1273.214 or mRNA-1273
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Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis N. Engl. J. Med. (IF 176.079) Pub Date : 2022-09-15 Enrique de-Madaria, James L. Buxbaum, Patrick Maisonneuve, Ana García García de Paredes, Pedro Zapater, Lucía Guilabert, Alicia Vaillo-Rocamora, Miguel Á. Rodríguez-Gandía, Jesús Donate-Ortega, Edgard E. Lozada-Hernández, Alan J.R. Collazo Moreno, Alba Lira-Aguilar, Laura P. Llovet, Rajiv Mehta, Raj Tandel, Pablo Navarro, Ana M. Sánchez-Pardo, Claudia Sánchez-Marin, Marina Cobreros, Idaira Fernández-Cabrera
New England Journal of Medicine, Volume 387, Issue 11, Page 989-1000, September 2022.
更新日期：2022-12-29
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