当前期刊: The New England Journal of Medicine Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Apgar Score and Risk of Neonatal Death among Preterm Infants
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-07-02
    Sven Cnattingius; Stefan Johansson; Neda Razaz

    New England Journal of Medicine, Volume 383, Issue 1, Page 49-57, July 2020.

    更新日期:2020-07-02
  • Randomized Trial of Amoxicillin for Pneumonia in Pakistan
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-07-02
    Fyezah Jehan; Imran Nisar; Salima Kerai; Benazir Balouch; Nick Brown; Najeeb Rahman; Arjumand Rizvi; Yasir Shafiq; Anita K.M. Zaidi

    Background The World Health Organization (WHO) recommends oral amoxicillin for patients who have pneumonia with tachypnea, yet trial data indicate that not using amoxicillin to treat this condition may be noninferior to using amoxicillin. Methods We conducted a double-blind, randomized, placebo-controlled noninferiority trial involving children at primary health care centers in low-income communities

    更新日期:2020-07-02
  • Amoxicillin for 3 or 5 Days for Chest-Indrawing Pneumonia in Malawian Children
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-07-02
    Amy-Sarah Ginsburg; Tisungane Mvalo; Evangelyn Nkwopara; Eric D. McCollum; Melda Phiri; Robert Schmicker; Jun Hwang; Chifundo B. Ndamala; Ajib Phiri; Norman Lufesi; Susanne May

    Background Evidence regarding the appropriate duration of treatment with antibiotic agents in children with pneumonia in low-resource settings in Africa is lacking. Methods We conducted a double-blind, randomized, controlled, noninferiority trial in Lilongwe, Malawi, to determine whether treatment with amoxicillin for 3 days is less effective than treatment for 5 days in children with chest-indrawing

    更新日期:2020-07-02
  • Multisystem Inflammatory Syndrome in Children in New York State
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-29
    Elizabeth M. Dufort; Emilia H. Koumans; Eric J. Chow; Elizabeth M. Rosenthal; Alison Muse; Jemma Rowlands; Meredith A. Barranco; Angela M. Maxted; Eli S. Rosenberg; Delia Easton; Tomoko Udo; Jessica Kumar; Wendy Pulver; Lou Smith; Brad Hutton; Debra Blog; Howard Zucker

    Background A multisystem inflammatory syndrome in children (MIS-C) is associated with coronavirus disease 2019. The New York State Department of Health (NYSDOH) established active, statewide surveillance to describe hospitalized patients with the syndrome. Methods Hospitals in New York State reported cases of Kawasaki’s disease, toxic shock syndrome, myocarditis, and potential MIS-C in hospitalized

    更新日期:2020-06-30
  • Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-29
    Leora R. Feldstein; Erica B. Rose; Steven M. Horwitz; Jennifer P. Collins; Margaret M. Newhams; Mary Beth F. Son; Jane W. Newburger; Lawrence C. Kleinman; Sabrina M. Heidemann; Amarilis A. Martin; Aalok R. Singh; Simon Li; Keiko M. Tarquinio; Preeti Jaggi; Matthew E. Oster; Sheemon P. Zackai; Jennifer Gillen; Adam J. Ratner; Rowan F. Walsh; Julie C. Fitzgerald; Michael A. Keenaghan; Hussam Alharash;

    Background Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal association with coronavirus disease 2019 (Covid-19) is important, given the clinical and public health implications of the syndrome. Methods We conducted targeted surveillance for MIS-C from March 15 to May 20, 2020, in pediatric health centers across the United States

    更新日期:2020-06-30
  • Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-24
    Klaus F. Rabe; Fernando J. Martinez; Gary T. Ferguson; Chen Wang; Dave Singh; Jadwiga A. Wedzicha; Roopa Trivedi; Earl St. Rose; Shaila Ballal; Julie McLaren; Patrick Darken; Magnus Aurivillius; Colin Reisner; Paul Dorinsky

    New England Journal of Medicine, Ahead of Print.

    更新日期:2020-06-25
  • Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-25
    Chandy C. John; Robert O. Opoka; Teresa S. Latham; Heather A. Hume; Catherine Nabaggala; Phillip Kasirye; Christopher M. Ndugwa; Adam Lane; Russell E. Ware

    Background Hydroxyurea has proven safety, feasibility, and efficacy in children with sickle cell anemia in sub-Saharan Africa, with studies showing a reduced incidence of vaso-occlusive events and reduced mortality. Dosing standards remain undetermined, however, and whether escalation to the maximum tolerated dose confers clinical benefits that outweigh treatment-related toxic effects is unknown. Methods

    更新日期:2020-06-25
  • Effect on Patient Safety of a Resident Physician Schedule without 24-Hour Shifts
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-25
    Christopher P. Landrigan; Shadab A. Rahman; Jason P. Sullivan; Eric Vittinghoff; Laura K. Barger; Amy L. Sanderson; Kenneth P. Wright; Conor S. O’Brien; Salim Qadri; Melissa A. St. Hilaire; Ann C. Halbower; Jeffrey L. Segar; John K. McGuire; Michael V. Vitiello; Horacio O. de la Iglesia; Sue E. Poynter; Pearl L. Yu; Phyllis C. Zee; Steven W. Lockley; Katie L. Stone; Charles A. Czeisler

    New England Journal of Medicine, Volume 382, Issue 26, Page 2514-2523, June 2020.

    更新日期:2020-06-25
  • Effects of Allopurinol on the Progression of Chronic Kidney Disease
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-25
    Sunil V. Badve; Elaine M. Pascoe; Anushree Tiku; Neil Boudville; Fiona G. Brown; Alan Cass; Philip Clarke; Nicola Dalbeth; Richard O. Day; Janak R. de Zoysa; Bettina Douglas; Randall Faull; David C. Harris; Carmel M. Hawley; Graham R.D. Jones; John Kanellis; Suetonia C. Palmer; Vlado Perkovic; Gopala K. Rangan; Donna Reidlinger; Laura Robison; Robert J. Walker; Giles Walters; David W. Johnson

    New England Journal of Medicine, Volume 382, Issue 26, Page 2504-2513, June 2020.

    更新日期:2020-06-25
  • Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-25
    Alessandro Doria; Andrzej T. Galecki; Cathie Spino; Rodica Pop-Busui; David Z. Cherney; Ildiko Lingvay; Afshin Parsa; Peter Rossing; Ronald J. Sigal; Maryam Afkarian; Ronnie Aronson; M. Luiza Caramori; Jill P. Crandall; Ian H. de Boer; Thomas G. Elliott; Allison B. Goldfine; J. Sonya Haw; Irl B. Hirsch; Amy B. Karger; David M. Maahs; Janet B. McGill; Mark E. Molitch; Bruce A. Perkins; Sarit Polsky;

    New England Journal of Medicine, Volume 382, Issue 26, Page 2493-2503, June 2020.

    更新日期:2020-06-25
  • Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-17
    David Ellinghaus,Frauke Degenhardt,Luis Bujanda,Maria Buti,Agustín Albillos,Pietro Invernizzi,Javier Fernández,Daniele Prati,Guido Baselli,Rosanna Asselta,Marit M Grimsrud,Chiara Milani,Fátima Aziz,Jan Kässens,Sandra May,Mareike Wendorff,Lars Wienbrandt,Florian Uellendahl-Werth,Tenghao Zheng,Xiaoli Yi,Raúl de Pablo,Adolfo G Chercoles,Adriana Palom,Alba-Estela Garcia-Fernandez,Francisco Rodriguez-Frias

    Background There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. Methods We conducted a genomewide association study involving

    更新日期:2020-06-18
  • Systematic or Test-Guided Treatment for Tuberculosis in HIV-Infected Adults.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-18
    François-Xavier Blanc,Anani D Badje,Maryline Bonnet,Delphine Gabillard,Eugène Messou,Conrad Muzoora,Sovannarith Samreth,Bang D Nguyen,Laurence Borand,Anaïs Domergue,Delphine Rapoud,Naome Natukunda,Sopheak Thai,Sylvain Juchet,Serge P Eholié,Stephen D Lawn,Serge K Domoua,Xavier Anglaret,Didier Laureillard,

    New England Journal of Medicine, Volume 382, Issue 25, Page 2397-2410, June 2020.

    更新日期:2020-06-18
  • Disseminated Coccidioidomycosis Treated with Interferon-γ and Dupilumab.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-11
    Monica Tsai,Timothy J Thauland,Alden Y Huang,Chantana Bun,Sean Fitzwater,Paul Krogstad,Emilie D Douine,Stanley F Nelson,Hane Lee,Maria I Garcia-Lloret,Manish J Butte

    New England Journal of Medicine, Volume 382, Issue 24, Page 2337-2343, June 2020.

    更新日期:2020-06-11
  • Thrombectomy for Stroke in the Public Health Care System of Brazil.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-11
    Sheila O Martins,Francisco Mont'Alverne,Letícia C Rebello,Daniel G Abud,Gisele S Silva,Fabrício O Lima,Bruno S M Parente,Guilherme S Nakiri,Mário B Faria,Michel E Frudit,João J F de Carvalho,Eduardo Waihrich,José A Fiorot,Fabrício B Cardoso,Raquel C T Hidalgo,Viviane F Zétola,Fernanda M Carvalho,Ana C de Souza,Francisco A Dias,Diego Bandeira,Maramélia Miranda Alves,Mário B Wagner,Leonardo A Carbonera

    New England Journal of Medicine, Volume 382, Issue 24, Page 2316-2326, June 2020.

    更新日期:2020-06-11
  • Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-11
    Manisha Balwani,Eliane Sardh,Paolo Ventura,Paula Aguilera Peiró,David C Rees,Ulrich Stölzel,D Montgomery Bissell,Herbert L Bonkovsky,Jerzy Windyga,Karl E Anderson,Charles Parker,Samuel M Silver,Siobán B Keel,Jiaan-Der Wang,Penelope E Stein,Pauline Harper,Daphne Vassiliou,Bruce Wang,John Phillips,Aneta Ivanova,Janneke G Langendonk,Raili Kauppinen,Elisabeth Minder,Yutaka Horie,Craig Penz,Jihong Chen

    New England Journal of Medicine, Volume 382, Issue 24, Page 2289-2301, June 2020.

    更新日期:2020-06-11
  • Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-04
    Véronique Minard-Colin,Anne Aupérin,Marta Pillon,G A Amos Burke,Donald A Barkauskas,Keith Wheatley,Rafael F Delgado,Sarah Alexander,Anne Uyttebroeck,Catherine M Bollard,József Zsiros,Monika Csoka,Bernarda Kazanowska,Alan K Chiang,Rodney R Miles,Andrew Wotherspoon,Peter C Adamson,Gilles Vassal,Catherine Patte,Thomas G Gross,,

    New England Journal of Medicine, Volume 382, Issue 23, Page 2207-2219, June 2020.

    更新日期:2020-06-04
  • A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-06-03
    David R Boulware,Matthew F Pullen,Ananta S Bangdiwala,Katelyn A Pastick,Sarah M Lofgren,Elizabeth C Okafor,Caleb P Skipper,Alanna A Nascene,Melanie R Nicol,Mahsa Abassi,Nicole W Engen,Matthew P Cheng,Derek LaBar,Sylvain A Lother,Lauren J MacKenzie,Glen Drobot,Nicole Marten,Ryan Zarychanski,Lauren E Kelly,Ilan S Schwartz,Emily G McDonald,Radha Rajasingham,Todd C Lee,Kathy H Hullsiek

    Background Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine. Whether hydroxychloroquine can prevent symptomatic infection after SARS-CoV-2 exposure is unknown. Methods We conducted a randomized, double-blind, placebo-controlled trial across the United

    更新日期:2020-06-03
  • Tepotinib in Non–Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations
    N. Engl. J. Med. (IF 74.699) Pub Date : 
    Paul K. Paik; Enriqueta Felip; Remi Veillon; Hiroshi Sakai; Alexis B. Cortot; Marina C. Garassino; Julien Mazieres; Santiago Viteri; Helene Senellart; Jan Van Meerbeeck; Jo Raskin; Niels Reinmuth; Pierfranco Conte; Dariusz Kowalski; Byoung Chul Cho; Jyoti D. Patel; Leora Horn; Frank Griesinger; Ji-Youn Han; Young-Chul Kim; Gee-Chen Chang; Chen-Liang Tsai; James C.-H. Yang; Yuh-Min Chen; Egbert F. Smit;

    New England Journal of Medicine, Ahead of Print.

    更新日期:2020-05-30
  • Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer
    N. Engl. J. Med. (IF 74.699) Pub Date : 
    Kohei Shitara; Yung-Jue Bang; Satoru Iwasa; Naotoshi Sugimoto; Min-Hee Ryu; Daisuke Sakai; Hyun-Cheol Chung; Hisato Kawakami; Hiroshi Yabusaki; Jeeyun Lee; Kaku Saito; Yoshinori Kawaguchi; Takahiro Kamio; Akihito Kojima; Masahiro Sugihara; Kensei Yamaguchi

    New England Journal of Medicine, Ahead of Print.

    更新日期:2020-05-30
  • Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer
    N. Engl. J. Med. (IF 74.699) Pub Date : 
    Neal D. Shore; Fred Saad; Michael S. Cookson; Daniel J. George; Daniel R. Saltzstein; Ronald Tutrone; Hideyuki Akaza; Alberto Bossi; David F. van Veenhuyzen; Bryan Selby; Xiaolin Fan; Vicky Kang; Jackie Walling; Bertrand Tombal

    New England Journal of Medicine, Ahead of Print.

    更新日期:2020-05-30
  • Enzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate Cancer
    N. Engl. J. Med. (IF 74.699) Pub Date : 
    Cora N. Sternberg; Karim Fizazi; Fred Saad; Neal D. Shore; Ugo De Giorgi; David F. Penson; Ubirajara Ferreira; Eleni Efstathiou; Katarzyna Madziarska; Michael P. Kolinsky; Daniel I. G. Cubero; Bettina Noerby; Fabian Zohren; Xun Lin; Katharina Modelska; Jennifer Sugg; Joyce Steinberg; Maha Hussain

    New England Journal of Medicine, Ahead of Print.

    更新日期:2020-05-30
  • WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-28
    Yu-Ru Lee,Lamis Yehia,Takahiro Kishikawa,Ying Ni,Brandie Leach,Jinfang Zhang,Nivedita Panch,Jing Liu,Wenyi Wei,Charis Eng,Pier Paolo Pandolfi

    New England Journal of Medicine, Volume 382, Issue 22, Page 2103-2116, May 2020.

    更新日期:2020-05-28
  • Remdesivir for 5 or 10 Days in Patients with Severe Covid-19.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-27
    Jason D Goldman,David C B Lye,David S Hui,Kristen M Marks,Raffaele Bruno,Rocio Montejano,Christoph D Spinner,Massimo Galli,Mi-Young Ahn,Ronald G Nahass,Yao-Shen Chen,Devi SenGupta,Robert H Hyland,Anu O Osinusi,Huyen Cao,Christiana Blair,Xuelian Wei,Anuj Gaggar,Diana M Brainard,William J Towner,Jose Muñoz,Kathleen M Mullane,Francisco M Marty,Karen T Tashima,George Diaz,Aruna Subramanian,

    Background Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy in animal models of coronavirus disease 2019 (Covid-19). Methods We conducted a randomized, open-label, phase 3 trial involving hospitalized patients with confirmed SARS-CoV-2 infection, oxygen saturation of 94% or less while they were breathing ambient air, and radiologic evidence of pneumonia

    更新日期:2020-05-27
  • Remdesivir for the Treatment of Covid-19 - Preliminary Report.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-22
    John H Beigel,Kay M Tomashek,Lori E Dodd,Aneesh K Mehta,Barry S Zingman,Andre C Kalil,Elizabeth Hohmann,Helen Y Chu,Annie Luetkemeyer,Susan Kline,Diego Lopez de Castilla,Robert W Finberg,Kerry Dierberg,Victor Tapson,Lanny Hsieh,Thomas F Patterson,Roger Paredes,Daniel A Sweeney,William R Short,Giota Touloumi,David Chien Lye,Norio Ohmagari,Myoung-Don Oh,Guillermo M Ruiz-Palacios,Thomas Benfield,Gerd

    BACKGROUND Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), none have yet been shown to be efficacious. METHODS We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive

    更新日期:2020-05-22
  • Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-21
    Maximilian Ackermann,Stijn E Verleden,Mark Kuehnel,Axel Haverich,Tobias Welte,Florian Laenger,Arno Vanstapel,Christopher Werlein,Helge Stark,Alexandar Tzankov,William W Li,Vincent W Li,Steven J Mentzer,Danny Jonigk

    BACKGROUND Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated morphologic and molecular changes in the peripheral lung of patients who die from Covid-19. METHODS We examined 7 lungs obtained during autopsy from patients who

    更新日期:2020-05-21
  • Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-14
    Jeffrey S Schweitzer,Bin Song,Todd M Herrington,Tae-Yoon Park,Nayeon Lee,Sanghyeok Ko,Jeha Jeon,Young Cha,Kyungsang Kim,Quanzheng Li,Claire Henchcliffe,Michael Kaplitt,Carolyn Neff,Otto Rapalino,Hyemyung Seo,In-Hee Lee,Jisun Kim,Taewoo Kim,Gregory A Petsko,Jerome Ritz,Bruce M Cohen,Sek-Won Kong,Pierre Leblanc,Bob S Carter,Kwang-Soo Kim

    We report the implantation of patient-derived midbrain dopaminergic progenitor cells, differentiated in vitro from autologous induced pluripotent stem cells (iPSCs), in a patient with idiopathic Parkinson's disease. The patient-specific progenitor cells were produced under Good Manufacturing Practice conditions and characterized as having the phenotypic properties of substantia nigra pars compacta

    更新日期:2020-05-14
  • Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-14
    Craig R Cohen,Michael R Wierzbicki,Audrey L French,Sheldon Morris,Sara Newmann,Hilary Reno,Lauri Green,Steve Miller,Jonathan Powell,Thomas Parks,Anke Hemmerling

    BACKGROUND Bacterial vaginosis affects 15 to 50% of women of reproductive age, and recurrence is common after treatment with an antibiotic agent. The high incidence of recurrence suggests the need for new treatments to prevent recurrent bacterial vaginosis. METHODS We conducted a randomized, double-blind, placebo-controlled, phase 2b trial to evaluate the ability of Lactobacillus crispatus CTV-05 (Lactin-V)

    更新日期:2020-05-14
  • Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-14
    Richard S Finn,Shukui Qin,Masafumi Ikeda,Peter R Galle,Michel Ducreux,Tae-You Kim,Masatoshi Kudo,Valeriy Breder,Philippe Merle,Ahmed O Kaseb,Daneng Li,Wendy Verret,Derek-Zhen Xu,Sairy Hernandez,Juan Liu,Chen Huang,Sohail Mulla,Yulei Wang,Ho Yeong Lim,Andrew X Zhu,Ann-Lii Cheng,

    BACKGROUND The combination of atezolizumab and bevacizumab showed encouraging antitumor activity and safety in a phase 1b trial involving patients with unresectable hepatocellular carcinoma. METHODS In a global, open-label, phase 3 trial, patients with unresectable hepatocellular carcinoma who had not previously received systemic treatment were randomly assigned in a 2:1 ratio to receive either atezolizumab

    更新日期:2020-05-14
  • Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-07
    Joshua Geleris,Yifei Sun,Jonathan Platt,Jason Zucker,Matthew Baldwin,George Hripcsak,Angelena Labella,Daniel K Manson,Christine Kubin,R Graham Barr,Magdalena E Sobieszczyk,Neil W Schluger

    BACKGROUND Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use. METHODS We examined the association between hydroxychloroquine use and intubation or death at a large medical center in New York City. Data were obtained regarding consecutive patients hospitalized with Covid-19, excluding those who were intubated, died, or discharged within

    更新日期:2020-05-07
  • Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-07
    Franco Locatelli,Michael B Jordan,Carl Allen,Simone Cesaro,Carmelo Rizzari,Anupama Rao,Barbara Degar,Timothy P Garrington,Julian Sevilla,Maria-Caterina Putti,Franca Fagioli,Martina Ahlmann,Jose-Luis Dapena Diaz,Michael Henry,Fabrizio De Benedetti,Alexei Grom,Genevieve Lapeyre,Philippe Jacqmin,Maria Ballabio,Cristina de Min

    BACKGROUND Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized by immune dysregulation and hyperinflammation. It typically manifests in infancy and is associated with high mortality. METHODS We investigated the efficacy and safety of emapalumab (a human anti-interferon-γ antibody), administered with dexamethasone, in an open-label, single-group, phase 2-3 study involving patients

    更新日期:2020-05-07
  • Infections Associated with Resterilized Pacemakers and Defibrillators.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-07
    Thomas F Khairy,Marie-Andrée Lupien,Santiago Nava,Frank Valdez Baez,Fernando Solares Ovalle,Nery E Linarez Ochoa,Gerardo Sosa Mendoza,Cesar A Carrazco,Christine Villemaire,Richard Cartier,Denis Roy,Mario Talajic,Marc Dubuc,Bernard Thibault,Peter G Guerra,Lena Rivard,Katia Dyrda,Blandine Mondésert,Rafik Tadros,Julia Cadrin-Tourigny,Laurent Macle,Paul Khairy

    BACKGROUND Access to pacemakers and defibrillators is problematic in places with limited resources. Resterilization and reuse of implantable cardiac devices obtained post mortem from patients in wealthier nations have been undertaken, but uncertainty around the risk of infection is a concern. METHODS A multinational program was initiated in 1983 to provide tested and resterilized pacemakers and defibrillators

    更新日期:2020-05-07
  • Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-06
    Pengfei Yang,Yongwei Zhang,Lei Zhang,Yongxin Zhang,Kilian M Treurniet,Wenhuo Chen,Ya Peng,Hongxing Han,Jiyue Wang,Shouchun Wang,Congguo Yin,Sheng Liu,Peng Wang,Qi Fang,Hongchao Shi,Jianhong Yang,Changming Wen,Conghui Li,Changchun Jiang,Jun Sun,Xincan Yue,Min Lou,Meng Zhang,Hansheng Shu,Dianjing Sun,Hui Liang,Tong Li,Fuqiang Guo,Kaifu Ke,Haicheng Yuan,Guoping Wang,Weimin Yang,Huaizhang Shi,Tianxiao

    BACKGROUND In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy. METHODS We conducted a trial at 41 academic tertiary care centers in China to evaluate endovascular thrombectomy with or without intravenous alteplase in patients with acute ischemic stroke. Patients with acute ischemic stroke from large-vessel

    更新日期:2020-05-06
  • Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-01
    Giuseppe Mancia,Federico Rea,Monica Ludergnani,Giovanni Apolone,Giovanni Corrao

    BACKGROUND A potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting-enzyme (ACE) inhibitors and the risk of coronavirus disease 2019 (Covid-19) has not been well studied. METHODS We carried out a population-based case-control study in the Lombardy region of Italy. A total of 6272 case patients in whom infection with severe acute respiratory syndrome

    更新日期:2020-05-01
  • Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-01
    Mandeep R Mehra,Sapan S Desai,SreyRam Kuy,Timothy D Henry,Amit N Patel

    BACKGROUND Coronavirus disease 2019 (Covid-19) may disproportionately affect people with cardiovascular disease. Concern has been aroused regarding a potential harmful effect of angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) in this clinical context. METHODS Using an observational database from 169 hospitals in Asia, Europe, and North America, we evaluated the

    更新日期:2020-05-01
  • Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-05-01
    Harmony R Reynolds,Samrachana Adhikari,Claudia Pulgarin,Andrea B Troxel,Eduardo Iturrate,Stephen B Johnson,Anaïs Hausvater,Jonathan D Newman,Jeffrey S Berger,Sripal Bangalore,Stuart D Katz,Glenn I Fishman,Dennis Kunichoff,Yu Chen,Gbenga Ogedegbe,Judith S Hochman

    BACKGROUND There is concern about the potential of an increased risk related to medications that act on the renin-angiotensin-aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin-converting enzyme 2 (ACE2). METHODS We assessed the relation between previous treatment with ACE inhibitors, angiotensin-receptor blockers, beta-blockers

    更新日期:2020-05-01
  • Association between Mental Disorders and Subsequent Medical Conditions.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-30
    Natalie C Momen,Oleguer Plana-Ripoll,Esben Agerbo,Michael E Benros,Anders D Børglum,Maria K Christensen,Søren Dalsgaard,Louisa Degenhardt,Peter de Jonge,Jean-Christophe P G Debost,Morten Fenger-Grøn,Jane M Gunn,Kim M Iburg,Lars V Kessing,Ronald C Kessler,Thomas M Laursen,Carmen C W Lim,Ole Mors,Preben B Mortensen,Katherine L Musliner,Merete Nordentoft,Carsten B Pedersen,Liselotte V Petersen,Anette

    BACKGROUND Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical conditions. METHODS We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016, for a total of 83.9 million person-years.

    更新日期:2020-04-30
  • Self-Contained Neuromusculoskeletal Arm Prostheses.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-30
    Max Ortiz-Catalan,Enzo Mastinu,Paolo Sassu,Oskar Aszmann,Rickard Brånemark

    We report the use of a bone-anchored, self-contained robotic arm with both sensory and motor components over 3 to 7 years in four patients after transhumeral amputation. The implant allowed for bidirectional communication between a prosthetic hand and electrodes implanted in the nerves and muscles of the upper arm and was anchored to the humerus through osseointegration, the process in which bone cells

    更新日期:2020-04-30
  • Olaparib for Metastatic Castration-Resistant Prostate Cancer.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-28
    Johann de Bono,Joaquin Mateo,Karim Fizazi,Fred Saad,Neal Shore,Shahneen Sandhu,Kim N Chi,Oliver Sartor,Neeraj Agarwal,David Olmos,Antoine Thiery-Vuillemin,Przemyslaw Twardowski,Niven Mehra,Carsten Goessl,Jinyu Kang,Joseph Burgents,Wenting Wu,Alexander Kohlmann,Carrie A Adelman,Maha Hussain

    BACKGROUND Multiple loss-of-function alterations in genes that are involved in DNA repair, including homologous recombination repair, are associated with response to poly(adenosine diphosphate-ribose) polymerase (PARP) inhibition in patients with prostate and other cancers. METHODS We conducted a randomized, open-label, phase 3 trial evaluating the PARP inhibitor olaparib in men with metastatic castration-resistant

    更新日期:2020-04-28
  • Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-24
    Melissa M Arons,Kelly M Hatfield,Sujan C Reddy,Anne Kimball,Allison James,Jesica R Jacobs,Joanne Taylor,Kevin Spicer,Ana C Bardossy,Lisa P Oakley,Sukarma Tanwar,Jonathan W Dyal,Josh Harney,Zeshan Chisty,Jeneita M Bell,Mark Methner,Prabasaj Paul,Christina M Carlson,Heather P McLaughlin,Natalie Thornburg,Suxiang Tong,Azaibi Tamin,Ying Tao,Anna Uehara,Jennifer Harcourt,Shauna Clark,Claire Brostrom-Smith

    BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can spread rapidly within skilled nursing facilities. After identification of a case of Covid-19 in a skilled nursing facility, we assessed transmission and evaluated the adequacy of symptom-based screening to identify infections in residents. METHODS We conducted two serial point-prevalence surveys, 1 week apart, in

    更新日期:2020-04-24
  • Hospitalizations and Deaths Associated with EVALI.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-23
    Angela K Werner,Emilia H Koumans,Kevin Chatham-Stephens,Phillip P Salvatore,Christina Armatas,Paul Byers,Charles R Clark,Isaac Ghinai,Stacy M Holzbauer,Kristen A Navarette,Melissa L Danielson,Sascha Ellington,Erin D Moritz,Emily E Petersen,Emily A Kiernan,Grant T Baldwin,Peter Briss,Christopher M Jones,Brian A King,Vikram Krishnasamy,Dale A Rose,Sarah Reagan-Steiner,

    BACKGROUND As of January 7, 2020, a total of 2558 hospitalized patients with nonfatal cases and 60 patients with fatal cases of e-cigarette, or vaping, product use-associated lung injury (EVALI) had been reported to the Centers for Disease Control and Prevention (CDC). METHODS In a national study, we compared the characteristics of patients with fatal cases of EVALI with those of patients with nonfatal

    更新日期:2020-04-23
  • Management of Coronary Disease in Patients with Advanced Kidney Disease.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-03-30
    Sripal Bangalore,David J Maron,Sean M O'Brien,Jerome L Fleg,Evgeny I Kretov,Carlo Briguori,Upendra Kaul,Harmony R Reynolds,Tomasz Mazurek,Mandeep S Sidhu,Jeffrey S Berger,Roy O Mathew,Olga Bockeria,Samuel Broderick,Radoslaw Pracon,Charles A Herzog,Zhen Huang,Gregg W Stone,William E Boden,Jonathan D Newman,Ziad A Ali,Daniel B Mark,John A Spertus,Karen P Alexander,Bernard R Chaitman,Glenn M Chertow,Judith

    BACKGROUND Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress testing to be treated with an initial invasive strategy consisting of coronary angiography and revascularization

    更新日期:2020-04-23
  • Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-03-30
    John A Spertus,Philip G Jones,David J Maron,Daniel B Mark,Sean M O'Brien,Jerome L Fleg,Harmony R Reynolds,Gregg W Stone,Mandeep S Sidhu,Bernard R Chaitman,Glenn M Chertow,Judith S Hochman,Sripal Bangalore,

    BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia

    更新日期:2020-04-23
  • Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-03-29
    Giancarlo Agnelli,Cecilia Becattini,Guy Meyer,Andres Muñoz,Menno V Huisman,Jean M Connors,Alexander Cohen,Rupert Bauersachs,Benjamin Brenner,Adam Torbicki,Maria R Sueiro,Catherine Lambert,Gualberto Gussoni,Mauro Campanini,Andrea Fontanella,Giorgio Vescovo,Melina Verso,

    BACKGROUND Recent guidelines recommend consideration of the use of oral edoxaban or rivaroxaban for the treatment of venous thromboembolism in patients with cancer. However, the benefit of these oral agents is limited by the increased risk of bleeding associated with their use. METHODS This was a multinational, randomized, investigator-initiated, open-label, noninferiority trial with blinded central

    更新日期:2020-04-23
  • Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-22
    Robert Zeiser,Nikolas von Bubnoff,Jason Butler,Mohamad Mohty,Dietger Niederwieser,Reuven Or,Jeff Szer,Eva M Wagner,Tsila Zuckerman,Bruyère Mahuzier,Judith Xu,Celine Wilke,Kunal K Gandhi,Gérard Socié,

    BACKGROUND Acute graft-versus-host disease (GVHD) remains a major limitation of allogeneic stem-cell transplantation; not all patients have a response to standard glucocorticoid treatment. In a phase 2 trial, ruxolitinib, a selective Janus kinase (JAK1 and JAK2) inhibitor, showed potential efficacy in patients with glucocorticoid-refractory acute GVHD. METHODS We conducted a multicenter, randomized

    更新日期:2020-04-22
  • A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-16
    Kenneth S Koblan,Justine Kent,Seth C Hopkins,John H Krystal,Hailong Cheng,Robert Goldman,Antony Loebel

    BACKGROUND An oral compound, SEP-363856, that does not act on dopamine D2 receptors but has agonist activity at trace amine-associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT1A) receptors, may represent a new class of psychotropic agent for the treatment of psychosis in schizophrenia. METHODS We performed a randomized, controlled trial to evaluate the efficacy and safety of SEP-363856

    更新日期:2020-04-15
  • Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-03-18
    Kausik K Ray,R Scott Wright,David Kallend,Wolfgang Koenig,Lawrence A Leiter,Frederick J Raal,Jenna A Bisch,Tara Richardson,Mark Jaros,Peter L J Wijngaard,John J P Kastelein,

    BACKGROUND Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin-kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing. METHODS We enrolled patients with atherosclerotic cardiovascular disease (ORION-10 trial) and patients with atherosclerotic cardiovascular disease or

    更新日期:2020-04-15
  • Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-16
    Frederick J. Raal; David Kallend; Kausik K. Ray; Traci Turner; Wolfgang Koenig; R. Scott Wright; Peter L.J. Wijngaard; Danielle Curcio; Mark J. Jaros; Lawrence A. Leiter; John J.P. Kastelein

    Background Familial hypercholesterolemia is characterized by an elevated level of low-density lipoprotein (LDL) cholesterol and an increased risk of premature atherosclerotic cardiovascular disease. Monoclonal antibodies directed against proprotein convertase subtilisin–kexin type 9 (PCSK9) have been shown to reduce LDL cholesterol levels by more than 50% but require administration every 2 to 4 weeks

    更新日期:2020-04-15
  • Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-14
    Dan Milea,Raymond P Najjar,Jiang Zhubo,Daniel Ting,Caroline Vasseneix,Xinxing Xu,Masoud Aghsaei Fard,Pedro Fonseca,Kavin Vanikieti,Wolf A Lagrèze,Chiara La Morgia,Carol Y Cheung,Steffen Hamann,Christophe Chiquet,Nicolae Sanda,Hui Yang,Luis J Mejico,Marie-Bénédicte Rougier,Richard Kho,Tran Thi Ha Chau,Shweta Singhal,Philippe Gohier,Catherine Clermont-Vignal,Ching-Yu Cheng,Jost B Jonas,Patrick Yu-Wai-Man

    BACKGROUND Nonophthalmologist physicians do not confidently perform direct ophthalmoscopy. The use of artificial intelligence to detect papilledema and other optic-disk abnormalities from fundus photographs has not been well studied. METHODS We trained, validated, and externally tested a deep-learning system to classify optic disks as being normal or having papilledema or other abnormalities from 15

    更新日期:2020-04-14
  • Spread of SARS-CoV-2 in the Icelandic Population.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-14
    Daniel F Gudbjartsson,Agnar Helgason,Hakon Jonsson,Olafur T Magnusson,Pall Melsted,Gudmundur L Norddahl,Jona Saemundsdottir,Asgeir Sigurdsson,Patrick Sulem,Arna B Agustsdottir,Berglind Eiriksdottir,Run Fridriksdottir,Elisabet E Gardarsdottir,Gudmundur Georgsson,Olafia S Gretarsdottir,Kjartan R Gudmundsson,Thora R Gunnarsdottir,Arnaldur Gylfason,Hilma Holm,Brynjar O Jensson,Aslaug Jonasdottir,Frosti

    BACKGROUND During the current worldwide pandemic, coronavirus disease 2019 (Covid-19) was first diagnosed in Iceland at the end of February. However, data are limited on how SARS-CoV-2, the virus that causes Covid-19, enters and spreads in a population. METHODS We targeted testing to persons living in Iceland who were at high risk for infection (mainly those who were symptomatic, had recently traveled

    更新日期:2020-04-14
  • Compassionate Use of Remdesivir for Patients with Severe Covid-19.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-10
    Jonathan Grein,Norio Ohmagari,Daniel Shin,George Diaz,Erika Asperges,Antonella Castagna,Torsten Feldt,Gary Green,Margaret L Green,François-Xavier Lescure,Emanuele Nicastri,Rentaro Oda,Kikuo Yo,Eugenia Quiros-Roldan,Alex Studemeister,John Redinski,Seema Ahmed,Jorge Bernett,Daniel Chelliah,Danny Chen,Shingo Chihara,Stuart H Cohen,Jennifer Cunningham,Antonella D'Arminio Monforte,Saad Ismail,Hideaki Kato

    BACKGROUND Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2. METHODS We provided remdesivir on a compassionate-use basis to patients hospitalized with Covid-19, the illness caused by infection with SARS-CoV-2. Patients were those with confirmed SARS-CoV-2 infection who had an oxygen saturation of 94% or less while they were

    更新日期:2020-04-10
  • Initial Invasive or Conservative Strategy for Stable Coronary Disease.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-03-30
    David J Maron,Judith S Hochman,Harmony R Reynolds,Sripal Bangalore,Sean M O'Brien,William E Boden,Bernard R Chaitman,Roxy Senior,Jose López-Sendón,Karen P Alexander,Renato D Lopes,Leslee J Shaw,Jeffrey S Berger,Jonathan D Newman,Mandeep S Sidhu,Shaun G Goodman,Witold Ruzyllo,Gilbert Gosselin,Aldo P Maggioni,Harvey D White,Balram Bhargava,James K Min,G B John Mancini,Daniel S Berman,Michael H Picard

    BACKGROUND Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when

    更新日期:2020-04-09
  • Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-03-30
    John A Spertus,Philip G Jones,David J Maron,Sean M O'Brien,Harmony R Reynolds,Yves Rosenberg,Gregg W Stone,Frank E Harrell,William E Boden,William S Weintraub,Khaula Baloch,Kreton Mavromatis,Ariel Diaz,Gilbert Gosselin,Jonathan D Newman,Stavroula Mavromichalis,Karen P Alexander,David J Cohen,Sripal Bangalore,Judith S Hochman,Daniel B Mark,

    BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the

    更新日期:2020-04-09
  • Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-09
    Gail D. Deyle; Chris S. Allen; Stephen C. Allison; Norman W. Gill; Benjamin R. Hando; Evan J. Petersen; Douglas I. Dusenberry; Daniel I. Rhon

    Background Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee. Whether the short-term and long-term effectiveness for relieving pain and improving physical function differ between these two therapies is uncertain. Methods We conducted a randomized trial to compare physical therapy with glucocorticoid

    更新日期:2020-04-09
  • Selumetinib in Children with Inoperable Plexiform Neurofibromas.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-09
    Andrea M Gross,Pamela L Wolters,Eva Dombi,Andrea Baldwin,Patricia Whitcomb,Michael J Fisher,Brian Weiss,AeRang Kim,Miriam Bornhorst,Amish C Shah,Staci Martin,Marie C Roderick,Dominique C Pichard,Amanda Carbonell,Scott M Paul,Janet Therrien,Oxana Kapustina,Kara Heisey,D Wade Clapp,Chi Zhang,Cody J Peer,William D Figg,Malcolm Smith,John Glod,Jaishri O Blakeley,Seth M Steinberg,David J Venzon,L Austin

    Background No approved therapies exist for inoperable plexiform neurofibromas in patients with neurofibromatosis type 1. Methods We conducted an open-label, phase 2 trial of selumetinib to determine the objective response rate among patients with plexiform neurofibromas and to assess clinical benefit. Children with neurofibromatosis type 1 and symptomatic inoperable plexiform neurofibromas received

    更新日期:2020-04-09
  • Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-02
    James Y.W. Lau; Yuanyuan Yu; Raymond S.Y. Tang; Heyson C.H. Chan; Hon-Chi Yip; Shannon M. Chan; Sally W.Y. Luk; Sunny H. Wong; Louis H.S. Lau; Rashid N. Lui; Ting T. Chan; Joyce W.Y. Mak; Francis K.L. Chan; Joseph J.Y. Sung

    Background It is recommended that patients with acute upper gastrointestinal bleeding undergo endoscopy within 24 hours after gastroenterologic consultation. The role of endoscopy performed within time frames shorter than 24 hours has not been adequately defined. Methods To evaluate whether urgent endoscopy improves outcomes in patients predicted to be at high risk for further bleeding or death, we

    更新日期:2020-04-03
  • Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012–2017
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-02
    John A. Jernigan; Kelly M. Hatfield; Hannah Wolford; Richard E. Nelson; Babatunde Olubajo; Sujan C. Reddy; Natalie McCarthy; Prabasaj Paul; L. Clifford McDonald; Alex Kallen; Anthony Fiore; Michael Craig; James Baggs

    Background Multidrug-resistant (MDR) bacteria that are commonly associated with health care cause a substantial health burden. Updated national estimates for this group of pathogens are needed to inform public health action. Methods Using data from patients hospitalized in a cohort of 890 U.S. hospitals during the period 2012–2017, we generated national case counts for both hospital-onset and community-onset

    更新日期:2020-04-03
  • Trends in U.S. Burden of Clostridioides difficile Infection and Outcomes
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-02
    Alice Y. Guh; Yi Mu; Lisa G. Winston; Helen Johnston; Danyel Olson; Monica M. Farley; Lucy E. Wilson; Stacy M. Holzbauer; Erin C. Phipps; Ghinwa K. Dumyati; Zintars G. Beldavs; Marion A. Kainer; Maria Karlsson; Dale N. Gerding; L. Clifford McDonald

    Background Efforts to prevent Clostridioides difficile infection continue to expand across the health care spectrum in the United States. Whether these efforts are reducing the national burden of C. difficile infection is unclear. Methods The Emerging Infections Program identified cases of C. difficile infection (stool specimens positive for C. difficile in a person ≥1 year of age with no positive

    更新日期:2020-04-03
  • KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-04-02
    Michael Wang; Javier Munoz; Andre Goy; Frederick L. Locke; Caron A. Jacobson; Brian T. Hill; John M. Timmerman; Houston Holmes; Samantha Jaglowski; Ian W. Flinn; Peter A. McSweeney; David B. Miklos; John M. Pagel; Marie-Jose Kersten; Noel Milpied; Henry Fung; Max S. Topp; Roch Houot; Amer Beitinjaneh; Weimin Peng; Lianqing Zheng; John M. Rossi; Rajul K. Jain; Arati V. Rao; Patrick M. Reagan

    Background Patients with relapsed or refractory mantle-cell lymphoma who have disease progression during or after the receipt of Bruton’s tyrosine kinase (BTK) inhibitor therapy have a poor prognosis. KTE-X19, an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, may have benefit in patients with relapsed or refractory mantle-cell lymphoma. Methods In a multicenter, phase 2 trial, we evaluated

    更新日期:2020-04-03
  • A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-03-31
    Aaron S Kelly,Pernille Auerbach,Margarita Barrientos-Perez,Inge Gies,Paula M Hale,Claude Marcus,Lucy D Mastrandrea,Nandana Prabhu,Silva Arslanian,

    New England Journal of Medicine, Ahead of Print.

    更新日期:2020-03-31
  • Covid-19 in Critically Ill Patients in the Seattle Region - Case Series.
    N. Engl. J. Med. (IF 74.699) Pub Date : 2020-03-30
    Pavan K Bhatraju,Bijan J Ghassemieh,Michelle Nichols,Richard Kim,Keith R Jerome,Arun K Nalla,Alexander L Greninger,Sudhakar Pipavath,Mark M Wurfel,Laura Evans,Patricia A Kritek,T Eoin West,Andrew Luks,Anthony Gerbino,Chris R Dale,Jason D Goldman,Shane O'Mahony,Carmen Mikacenic

    BACKGROUND Community transmission of coronavirus 2019 (Covid-19) was detected in the state of Washington in February 2020. METHODS We identified patients from nine Seattle-area hospitals who were admitted to the intensive care unit (ICU) with confirmed infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Clinical data were obtained through review of medical records. The data

    更新日期:2020-03-30
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
自然科研论文编辑服务
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
鲁照永
复旦大学
苏州大学
南京工业大学
南开大学
中科大
唐勇
跟Nature、Science文章学绘图
隐藏1h前已浏览文章
中洪博元
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
x-mol收录
广东实验室
南京大学
陈永胜
南科大
刘尊峰
湖南大学
清华大学
王小野
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug