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Missing the Mark? American College of Rheumatology 2019 Guidelines for Intraarticular Hyaluronic Acid Injection and Osteoarthritis Knee Pain. J. Rheumatol. (IF 5.346) Pub Date : 2022-08-01 Roy D Altman,Robert W Ike,Max I Hamburger,David A McLain,Michael J Daley,Thomas C Adamson
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Early abnormal nailfold capillary changes are predictive of calcinosis development in juvenile dermatomyositis. J. Rheumatol. (IF 5.346) Pub Date : 2022-08-01 Tomo Nozawa, Audrey Bell-Peter, Jo-Anne Marcuz, Kristi Whitney, Ophir Vinik, Rachel Shupak, Saunya Dover, Brian M Feldman
The long-term outcomes of juvenile dermatomyositis (JDM) are more favorable in recent years. However, calcinosis is still among the complications that can cause serious functional impairment. Little is known about the pathogenesis and risk factors of calcinosis. The aim of this study is to determine risk factors for the development of calcinosis in JDM.
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Timing and Predictors of Incident Cardiovascular Disease in Systemic Lupus Erythematosus: Risk Occurs Early and Highlights Racial Disparities. J. Rheumatol. (IF 5.346) Pub Date : 2022-08-01 Shivani Garg, Christie M Bartels, Gaobin Bao, Charles G Helmick, Cristina Drenkard, S Sam Lim
Systemic lupus erythematosus (SLE) affects Black people two to three times more frequently than non-Black people and is associated with higher morbidity and mortality. Four predominantly non-Black SLE cohorts highlighted that cardiovascular disease (CVD) is no longer primarily a late complication of SLE. This study assessed the timing and predictors of incident CVD in a predominantly Black population-based
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Pediatric to Adult Transition Literature: Scoping Review and Rheumatology Research Prioritization Survey Results. J. Rheumatol. (IF 5.346) Pub Date : 2022-08-01 Nicole Bitencourt, Erica Lawson, John Bridges, Kristine Carandang, Ela Chintagunta, Peter Chiraseveenuprapund, Kimberly DeQuattro, Y Ingrid Goh, Tzielan C Lee, Katharine F Moore, Rosemary G Peterson, Jordan E Roberts, Tova Ronis, Rebecca E Sadun, Emily A Smitherman, Elizabeth Stringer, Patience H White, Joyce C Chang
The transition from pediatric to adult care is the focus of growing research. It is important to identify how to direct future research efforts for maximum impact. Our goals were to perform a scoping review of the transition literature, highlight gaps in transition research, and offer stakeholder guidance on the importance and feasibility of research questions designed to fill identified gaps.The transition
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A Rare Case of Subcutaneous Sarcoidosis in Patient With Psoriatic Arthritis. J. Rheumatol. (IF 5.346) Pub Date : 2022-08-01 Pedro Bernardo Santos, Maria Manuela Loureiro, Anabela Barcelos
Sarcoidosis is a multisystem chronic inflammatory disorder of unknown etiology characterized by noncaseating granulomas.1 In the literature, we found a few cases of sarcoidosis combined with psoriasis and psoriatic arthritis (PsA), in patients treated with anti-tumor necrosis factor inhibitors2 and secukinumab.3 However, the coexistence of isolated cutaneous sarcoidosis and PsA is rare.4,5.
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Chilblains After SARS-CoV-2 Vaccination: Coincidence or Real Association? J. Rheumatol. (IF 5.346) Pub Date : 2022-08-01 Anastasios Karamanakos, Gerasimos Evangelatos, Maria Pappa, Kalliopi Fragiadaki, Antonis Fanouriakis, George E Fragoulis
We read with great interest the article of Meara et al1 in your journal describing a case of chilblain-like lesions after vaccination against SARS-CoV-2. Since the start of the coronavirus disease 2019 (COVID-19) pandemic, millions of vaccine doses have been administered and their safety has been generally confirmed.
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The sensitivity to change of the ASAS Health Index in an observational real-life cohort study. J. Rheumatol. (IF 5.346) Pub Date : 2022-08-01 Anne Constanze Regierer, Anja Weiß, Uta Kiltz, Joachim Sieper, Ilka Schwarze, Martin Bohl-Bühler, Herbert Kellner, Denis Poddubnyy, Angela Zink, Jürgen Braun, Joachim Listing, Anja Strangfeld
The ASAS health index (ASAS-HI) measures global functioning and health in axSpA patients covering domains of physical, emotional and social functioning. Main aim was to investigate the sensitivity to change of ASAS-HI in comparison with established parameters of disease activity, function, and mental health.
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Trajectory of Damage Accrual in Systemic Lupus Erythematosus based on Ethnicity and Socioeconomic Factors. J. Rheumatol. (IF 5.346) Pub Date : 2022-08-01 Romy Kallas, Jessica Li, Daniel W Goldman, Laurence S Magder, Michelle Petri
The Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI) is associated with increased healthcare cost and mortality. We compared the trajectory of total and individual damage items of the SLICC/ACR DI in African-American vs Caucasian ethnicities in a large prospective SLE cohort. We also estimated the association between ethnicity and individual
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Taking the Long View: Patients Perceive Benefits and Risks of Treatment as Multidimensional. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Shilpa Venkatachalam, W Benjamin Nowell
As a chronic and systemic inflammatory condition, rheumatoid arthritis (RA) affects people's quality of life (QOL), with symptoms ranging from pain and fatigue to stiffness and restricted physical mobility. The availability of a number of longstanding and newer RA therapeutic options has helped combat troublesome aspects of the disease, including progressive joint erosion and damage.
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Differentially expressed inflammation-regulating microRNAs in oligoarticular juvenile idiopathic arthritis. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Sarah M McAlpine, Sarah E Roberts, Breanna K V Hargreaves, Claire Bullock, Suzanne Ramsey, Elizabeth Stringer, Bianca Lang, Adam Huber, Bence György, Fruzsina Erdélyi, Thomas B Issekutz, Beáta Dérfalvi
To evaluate microRNA expression in synovial fluid (SF), plasma and leukocytes from patients with juvenile idiopathic arthritis (JIA).
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Risk Factors for Dementia in Patients with Incident Rheumatoid Arthritis: A Population-based Cohort Study. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Chanakya Kodishala, Cassondra A Hulshizer, Vanessa L Kronzer, John M Davis, Vijay K Ramanan, Maria Vassilaki, Michelle M Mielke, Cynthia S Crowson, Elena Myasoedova
Growing evidence suggests that patients with rheumatoid arthritis (RA) have increased risk for dementia. We assessed risk factors for incident dementia in an inception cohort of RA.
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Narrative review of machine learning in rheumatic and musculoskeletal diseases for clinicians and researchers: biases, goals, and future directions. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Amanda E Nelson, Liubov Arbeeva
There has been rapid growth in the use of artificial intelligence analytics in medicine in recent years, including in rheumatic and musculoskeletal diseases (RMDs). Such methods represent a challenge to clinicians, patients, and researchers given the "black box" nature of most algorithms and the unfamiliarity of the terms and lack of awareness of potential issues around these analyses. Therefore, this
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Dual Energy CT Has Additional Prognostic Value over Clinical Measures in Gout Including Tophi: A Systematic Literature Review. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Sally K Stauder, Paul M Peloso
This Systematic Literature Review determined whether there is clinical utility for Dual Energy CT (DECT) to inform on prognosis for gout patients. With DECT, individualized treatment plans could be developed based on the patient's unique urate burden, with DECT used as a clinical outcome measure in gout management.
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Development and validation of a self-administered questionnaire measuring essential knowledge in patients with axial spondyloarthritis. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Catherine Beauvais, Bruno Pereira, Thao Pham, Christelle Sordet, Pascal Claudepierre, Françoise Fayet, Daniel Wendling, Félicie Costantino, Laurence Carton, Laurent Grange, Martin Soubrier, Nathalie Legoupil, Aleth Perdriger, Isabel Tavares, Emmanuelle Dernis, Laure Gossec, Malory Rodère
To develop and validate a patient knowledge questionnaire regarding axial spondyloarthritis (axSpA).
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Relationship between inflammation and radiographic progression in patients with ankylosing spondylitis attaining a BASDAI of <4 during TNF inhibitor treatment. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Bon San Koo, Ji Seon Oh, Seo Young Park, Ji Hui Shin, Bora Nam, Seunghun Lee, Kyung Bin Joo, Tae-Hwan Kim
To determine the relationship between inflammation and radiographic progression over time in patients with ankylosing spondylitis (AS) attaining a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) of <4 during tumor necrosis factor inhibitor (TNFi) treatment.
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Impact of Fatigue on Health-Related Quality of Life and Work Productivity in Psoriatic Arthritis: Findings From a Real-World Survey. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Laure Gossec, Jessica A Walsh, Kaleb Michaud, Elizabeth Holdsworth, Steve Peterson, Sophie Meakin, Feifei Yang, Nicola Booth, Soumya D Chakravarty, James Piercy, Natalie Dennis, Alexis Ogdie
To evaluate fatigue frequency and severity among patients with psoriatic arthritis (PsA) and assess the impact of fatigue severity on patient-reported outcome measures (PROMs) assessing quality of life, function, and work productivity.
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Canadian Rheumatology Association living guidelines for the pharmacological management of rheumatoid arthritis with disease-modifying anti-rheumatic drugs. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Glen S Hazlewood, Jordi Pardo Pardo, Cheryl Barnabe, Orit Schieir, Claire E H Barber, Laurie Proulx, Dawn P Richards, Peter Tugwell, Nick Bansback, Pooneh Akhavan, Claire Bombardier, Vivian Bykerk, Shahin Jamal, Majed Khraishi, Regina Taylor-Gjevre, Carter Thorne, Arnav Agarwal, Janet E Pope
To provide the initial installment of a living guideline that will provide up-to-date guidance on the pharmacological management of patients with rheumatoid arthritis (RA) in Canada.
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An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Maria L Taylor, Kacie J Hoyt, Joseph Han, Leslie Benson, Siobhan Case, Mia T Chandler, Margaret H Chang, Craig Platt, Ezra M Cohen, Megan Day-Lewis, Fatma Dedeoglu, Mark Gorman, Jonathan S Hausmann, Erin Janssen, Pui Y Lee, Jeffrey Lo, Gregory P Priebe, Mindy S Lo, Esra Meidan, Peter A Nigrovic, Jordan E Roberts, Mary Beth F Son, Robert P Sundel, Maria Alfieri, Jenny Chan Yeun, Damilola M Shobiye,
To compare clinical outcomes in children with hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) who were managed before and after implementation of an evidence-based guideline (EBG).
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Simplified Ankylosing Spondylitis Disease Activity Score (SASDAS) Versus ASDAS: A Post Hoc Analysis of a Randomized Controlled Trial. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Emilce E Schneeberger, Gustavo Citera, Dario Ponce de Leon, Annette E Szumski, Kenneth Kwok, Mariel Cutri, Maxime Dougados
To compare the Simplified Ankylosing Spondylitis Disease Activity Score (SASDAS) against the Ankylosing Spondylitis Disease Activity Score (ASDAS) for measuring and categorizing disease activity using data from the EMBARK trial (ClinicalTrials.gov: NCT01258738), a randomized controlled trial of etanercept (ETN) for axial spondyloarthritis (axSpA).
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ANCA-Associated Vasculitides Valvular Impairment: Multicenter Retrospective Study and Systematic Review of the Literature. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-15 Lina Jeantin, Tiphaine Lenfant, Pierre Bataille, Hubert de Boysson, Pascal Cathébras, Christian Agard, Stanislas Faguer, Vincent Poindron, Marc Ruivard, Nicolas Martin Silva, Matthieu Monge, Loic Guillevin, Xavier Puéchal, Benjamin Terrier, Agnès Dechartres, Pierre Charles
While myocardial impairment is a predictor of poor prognosis in ANCA-associated vasculitides (AAV), little is known about valvular involvement. This study aims at describing the clinical presentation, management and outcome of endocarditis associated with AAV.
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Dr. Trefond et al reply: Giant Cell Arteritis After SARS-CoV-2 Vaccination-Coincidence or Trigger? J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Ludovic Trefond,Agathe Sauret,Julien Stievenart,Louis Olagne,Benedicte Guelon,Perrine Smets,Olivier Aumaître,Marc André
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Getting the Diagnosis Right: What's in a Name? J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Soumya Chatterjee
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The risk of inflammatory bowel disease in patients with axial spondyloarthritis treated with biologic agents: BSRBR-AS and meta-analysis. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Gary J Macfarlane,Renke Biallas,Linda E Dean,Gareth T Jones,Nicola J Goodson,Ovidiu Rotariu
OBJECTIVE To determine, amongst patients with axial spondyloarthritis (axSpA), whether the risk of inflammatory bowel disease (IBD) varies between patients treated with biologic and other therapies, and whether specifically the risk is higher in patients treated with etanercept. METHODS The British Society for Rheumatology Biologics Register in Ankylosing Spondylitis (BSRBRAS) was used to determine
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Physical Activity Associates with Lower Systemic Inflammatory Gene Expression in Rheumatoid Arthritis. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Sarah L Patterson,Shenghuan Sun,Dmitry Rychkov,Patricia Katz,Alexandra Tsitsiklis,Mary C Nakamura,Paula Hayakawa Serpa,Charles R Langelier,Marina Sirota
OBJECTIVE While general population studies have shown inverse associations between physical activity and common inflammatory biomarkers, the effects of physical activity on inflammatory gene expression and signaling pathways in rheumatoid arthritis (RA) remain unknown. We aimed to determine whether physical activity independently associates with expression of inflammatory genes among people with RA
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Unveiling Deficiency of Adenosine Deaminase 2: An Adult Patient With Recurrent Strokes, Vasculitic Ulcers, and Bowel Perforation. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Francesca Trentin,Linda Carli,Chiara Tani,Marta Mosca
Here we describe the case of a 38-year-old man with a history of ischemic transient attacks and strokes from the age of 9 years, livedo reticularis, asymmetrical sensorimotor neuropathy, optic neuritis, testicular ischemia, digital ulcers, ulcerative colitis, and diastolic hypertension. Disease course was characterized by severe disease bouts treated with high-dose intravenous (IV) glucocorticoid (GC)
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A Case of Rowell Syndrome Manifested on Hands: Targetoid-like Lesions and Nailfold Capillaries. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Wenting Hu,Yangyang Ma,Ping Wang,Ai-E Xu
Rowell syndrome is the occurrence of erythema multiforme-like lesions in patients with cutaneous lesions of lupus erythematosus.1 We present a young female patient with systemic lupus erythematosus (SLE), whose hand lesions exhibited both connective tissue disease-related periungual angiotelectasis and the typical erythema multiforme.
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COVID-19 vaccine uptake among patients with systemic lupus erythematosus in the American Midwest: The Lupus Midwest Network (LUMEN). J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Baptiste Chevet,Gabriel Figueroa-Parra,Jeffrey X Yang,Cassondra A Hulshizer,Tina M Gunderson,Stephanie Q Duong,Michael S Putman,Kamil E Barbour,Cynthia S Crowson,Alí Duarte-García
OBJECTIVE Systemic lupus erythematosus (SLE) patients are at higher risk of poor outcomes from coronavirus disease 2019 (COVID-19). The vaccination rate among such patients is unknown. We aimed to assess COVID-19 vaccine uptake among SLE patients. METHODS We included 342 SLE patients from the Lupus Midwest Network and 350 age, sex, race, and county matched comparators. Vaccination uptake for influenza
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Could Sampling Bias Be to Blame for Apparent Association Among Rheumatic Diseases? J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Pei-Yu Liao,Chun Hsien Wu,Yu-Chen Guo,Je-Kuei Yang,James Cheng-Chung Wei
We have read with great interest the recent study by Meer et al on novel methods to identify risk factors for psoriatic arthritis (PsA), psoriasis, rheumatoid arthritis (RA), and ankylosing spondylitis.1 In that article, we appreciate that age, sex, BMI (calculated as weight in kilograms divided by height in meters squared), and time observed between the experimental group and control group were highly
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Long-term follow-up of a randomised controlled trial of allopurinol dose escalation to achieve target serum urate in people with gout. J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 George B Coleman,Nicola Dalbeth,Chris Frampton,Janine Haslett,Jill Drake,Isabel Su,Anne M Horne,Lisa K Stamp
OBJECTIVE To determine long-term use of and adherence with urate lowering therapy (ULT), serum urate (SU) control, and self-reported flares in participants from a randomised controlled trial of allopurinol dose escalation to achieve target SU (<0.36 mmol/L) in people with gout. METHODS For surviving study participants, ULT dispensing and SU testing within the preceding 12 months was obtained by medical
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Is It Good to Simplify Clinimetry in Chronic Inflammatory Joint Diseases? J. Rheumatol. (IF 5.346) Pub Date : 2022-07-01 Marco Di Carlo,Fausto Salaffi
The measurement of disease activity in chronic inflammatory joint diseases represents a challenge that rheumatologists have faced head-on over the past decades. Disease activity is a complex phenomenon that, necessarily, must consider multiple domains of health.
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Novel Biomarker of Collagen Degradation can Identify Patients Affected with both Axial Spondyloarthritis and Crohn's Disease. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Signe Holm Nielsen, Andrew Stahly, Emilie H Regner, Anne-Christine Bay-Jensen, Morten Karsdal, Kristine A Kuhn
Chronic inflammatory arthritis is a hallmark of axial spondyloarthritis (axSpA), where co-existence of Crohn's Disease (CD) is prominent. We investigated the association between biomarkers of collagen degradation in healthy controls (HC) and patients with axSpA, CD and CD-axSpA overlap, with the aim to investigate the biomarkers' ability to identify patients with CD-axSpA overlap.
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Impact of a Wearable Activity Tracker on Disease Flares in Spondyloarthritis: A Randomized Controlled Trial. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Guillaume Labat, Meggy Hayotte, Laurent Bailly, Roxane Fabre, Olivier Brocq, Pauline Gerus, Véronique Breuil, Manuella Fournier-Mehouas, Raphaël Zory, Fabienne D'Arripe-Longueville, Christian H Roux
To evaluate the impact of a wearable activity tracker used to encourage physical activity, on disease flares in spondyloarthritis patients.
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Coexisting of anti-Ro52 autoantibodies on anti-MDA5 autoantibodies-positive dermatomyositis is highly associated with rapidly progressive interstitial lung disease and mortality risk. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Chengyin Lv, Hanxiao You, Lingxiao Xu, Lei Wang, Fenghong Yuan, Ju Li, Min Wu, Shiliang Zhou, Zhanyun Da, Jie Qian, Hua Wei, Wei Yan, Lei Zhou, Yan Wang, Songlou Yin, Dongmei Zhou, Jian Wu, Yan Lu, Dinglei Su, Zhichun Liu, Lin Liu, Longxin Ma, Xiaoyan Xu, Yinshan Zang, Huijie Liu, Tianli Ren, Fang Wang, Miaojia Zhang, Wenfeng Tan
Interstitial lung disease (ILD) is a common extramuscular complication contributing to significant morbidity and mortality in anti-melanoma differentiation associated gene 5 positive dermatomyositis (anti-MDA5+ DM). We conducted this study to investigate the association of anti-Ro52 antibodies with clinical characteristics and prognosis in anti-MDA5+ DM patients.
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Dr. Deng et al reply. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Hao Deng, Xiu Hong Yang, Hui Min Jin
We sincerely appreciate Dr. Kawada's comments in response to our metaanalysis.1 We agree with most of these opinions and would like to clarify our views here.
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Long-term behavioral changes during the COVID-19 pandemic and impact of vaccination in patients with inflammatory rheumatic diseases. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Bente Glintborg, Dorte Vendelbo Jensen, Lene Terslev, Oliver Hendricks, Mikkel Østergaard, Simon Horskjær Rasmussen, Mogens Pfeiffer Jensen, Thomas Adelsten, Ada Colic, Kamilla Danebod, Malene Kildemand, Anne Gitte Loft, Heide Lausten Munk, Jens Kristian Pedersen, René Drage Østgård, Christian Møller Sørensen, Niels Steen Krogh, Jette Nørgaard Agerbo, Connie Ziegler, Merete Lund Hetland
To explore anxiety and self-isolation 15 months into the COVID-19 pandemic including attitudes towards and impact of SARS-CoV-2 vaccination in patients with inflammatory rheumatic disease (IRD).
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Extravascular Necrotizing Granuloma: A Diagnostic Clue for Eosinophilic Granulomatosis With Polyangiitis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Naoki Tanomogi, Mana Kubota, Miyuki Kato
Extravascular necrotizing granuloma is pathologically one of the most characteristic findings of eosinophilic granulomatosis with polyangiitis (EGPA). A 46-year-old man presented to the rheumatology clinic with a 2-week history of arthralgia and 4-day history of dysesthesia of the feet.
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Evaluation of patients with rheumatoid arthritis in teleconsultation during the first wave of the COVID-19 pandemic. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Jérôme Avouac, Anna Molto, Camélia Frantz, Sarah Wanono, Elise Descamps, Olivier Fogel, Alice Combier, Lucile Poiroux, Corinne Miceli-Richard, Yannick Allanore
To describe which parameters were collected by rheumatologists to monitor patients with rheumatoid arthritis (RA) during teleconsultation and identify which ones have more impact on clinician intervention.
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Melorheostosis or "Dripping Candle Wax" Bone Disease. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Solène Remize, Benoit De Courtivron, Médéric Jeanne
Melorheostosis, also known as Leri-Joanny disease,1 is a very rare skeletal dysplasia manifesting as regions of bone sclerosis with a characteristic flowing candle wax appearance in the classical form of the disease. In addition to this classical pattern, 3 other types of melorheostosis have been described: osteoma-like, osteopathia striata-like, and myositis ossificans-like.
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Follow-up contrast-enhanced ultrasonography of the carotidartery in patients with Takayasu arteritis: A retrospective study. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Jin Ding, Dangjie Wu, Qing Han, Kui Zhang, Zhaohui Zheng, Ping Zhu
The literature describing follow-up carotid contrast-enhanced ultrasonography (CEUS) is limited. We report our experience with monitoring CEUS performed in patients with Takayasu arteritis (TAK).
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Clinical Heterogeneity of Patients With Antinuclear Matrix Protein 2 Antibody-Positive Myositis: A Retrospective Cohort Study in China. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Shanshan Li, Chao Sun, Ling Zhang, Junfeng Han, Hanbo Yang, Suhao Gao, Linrong He, Peiyao Zhang, Xin Lu, Xiaoming Shu, Guochun Wang
Heterogeneity exists among patients with myositis who have antinuclear matrix protein 2 (anti-NXP2) antibodies, although they usually present with severe muscle weakness. This study aimed to investigate the differences in phenotypes and prognoses among adult patients with myositis who have anti-NXP2 antibodies.
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A Novel Antineutrophil Extracellular Trap Antibody Targeting Myosin Light Chain 6 in Microscopic Polyangiitis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Miku Yoshinari, Fumihiko Hattanda, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by ANCA production in the serum. This disease entity includes microscopic polyangiitis (MPA). Previous studies have revealed that neutrophils excessively activated by ANCA and other serum factors are critically involved in AAV pathogenesis1.
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Febuxostat Use and Safety in Patients With Hyperuricemia. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Tomoyuki Kawada
I read the paper by Deng et al,1 in which the authors conducted a metaanalysis to evaluate whether febuxostat use increased the risk of developing cardiovascular (CV) events, cardiac death, and all-cause mortality. The adjusted relative risk (RR) of febuxostat use for all-cause mortality was 0.87 (95% CI 0.57-1.32).
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The Patient Experience of Drug Side Effects in Rheumatoid Arthritis: Intriguing Data From an Exploratory Online Survey. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 John M Davis
Understanding adverse events (AEs) of disease-modifying antirheumatic drugs (DMARDs) for treatment of rheumatoid arthritis (RA) is critical to both patients and clinicians. AEs-"side effects" from the patient perspective-contribute significantly to patients' disease experience by interfering with activities of daily living and quality of life (QOL).1.
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Anti-melanoma differentiation-associated gene 5 antibody-positive interstitial lung disease after vaccination with COVID-19 mRNA vaccines. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Takamasa Kitajima, Atsushi Funauchi, Toshiki Nakajima, Satoshi Marumo, Yoshitaka Imura, Motonari Fukui
Melanoma differentiation-associated gene 5 (MDA5) is a viral RNA sensor induced by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Similarities have been reported between the clinical presentations of coronavirus disease 2019 (COVID-19) pneumonia and anti-MDA5 antibody-positive interstitial lung disease (anti-MDA5-ILD). However, it is unknown whether COVID-19 mRNA vaccines are associated
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IgG4-related Disease Mimicking a Paratesticular Tumor and Pelvic Lymph Node Metastasis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Eri Sugawara, Taiki Sato, Kazuaki Katsumata
IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory disease characterized by tumor-like mass with infiltration of IgG4-positive plasma cells.1.
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The association of index-to-ring finger ratio with trapeziometacarpal joint osteoarthritis in an elderly Korean population. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-15 Ji Sup Hwang, Sanghoon Lee, Jung Wook Shin, Ki Woong Kim, Hyun Sik Gong
Index-to-ring finger ratio (IRFR) has been reported to be associated with joint osteoarthritis (OA). We aimed to evaluate the association between IRFR and trapeziometacarpal joint (TMCJ) OA in an elderly Korean population.
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Any Given Monday: Association Between Desk Rejections and Weekend Manuscript Submissions to Rheumatology Journals. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Michael Putman,Jilaine Bolek Berquist,Eric M Ruderman,Jeffrey A Sparks
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Canadian Rheumatology Association Meeting Virtual Conference, February 2-5, 2022. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01
The 76th Annual Meeting of the Canadian Rheumatology Association was held virtually on February 2-5, 2022. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2022 Award Winners: Distinguished Rheumatologist, John G. Hanly and Lori B. Tucker; Distinguished Teacher- Educator, Stephen Aaron; Emerging Investigator
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Apremilast Use in Oligoarticular Psoriatic Arthritis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Vicenç Torrente-Segarra, Maria Bonet
We read with interest the article published in The Journal of Rheumatology by Ogdie et al1 in which apremilast monotherapy showed more benefit in a specific subset of the psoriatic arthritis (PsA) population (oligoarticular pattern), compared to methotrexate (MTX) and biologic disease-modifying antirheumatic drugs (bDMARDs). The authors collected baseline and follow-up data (6-month period) regarding
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Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset SLE with Macrophage Activation Syndrome. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M Levy, Melissa Misztal, Lawrence W K Ng, Linda T Hiraki
Macrophage activation syndrome (MAS), a life-threatening complication of SLE, resembles familial hemophagocytic lymphohistiocytosis (fHLH), an inherited disorder of hyperinflammation. We compared the proportion of childhood-onset SLE (cSLE) patients with and without MAS, who carried low-frequency HLH non-synonymous variants.
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Effectiveness of Disease Modifying Anti-Rheumatic Drugs for Enthesitis in a Prospective Longitudinal Psoriatic Arthritis Cohort. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Ashish Jacob Mathew, Mitchell Sutton, Daniel Pereira, Dafna D Gladman, Vinod Chandran
Our objective was to assess the effectiveness of conventional and targeted disease modifying anti-rheumatic drugs (cDMARDs and tDMARDs, respectively) in treating enthesitis in PsA.
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Fear of the Unknown: Can We Help Individuals With a Systemic Autoimmune Rheumatic Disease Deal With Uncertainty? J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Gwenda Simons, Marie Falahee
Unfortunately, not much is certain in systemic autoimmune rheumatic diseases (SARDs). People with a SARD such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are dealing with a chronic, inflammatory, and often unpredictable autoimmune condition that might cause them to experience illness-related uncertainty.1,2.
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Patient acceptable symptom state for burden from appearance changes in people with systemic sclerosis: a cross-sectional survey. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Myrianne-Fleur Le Ralle, Camille Daste, François Rannou, Linda Kwakkenbos, Marie-Eve Carrier, Marie-Martine Lefèvre-Colau, Alexandra Roren, Brett D Thombs, Luc Mouthon, Christelle Nguyen
People with systemic sclerosis (SSc) often report substantial burden from appearance changes. We aimed to estimate the patient acceptable symptom state (PASS) for burden from appearance changes in people with SSc.
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A practical guide for assessment of skin burden in patients with psoriatic arthritis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Fazira R Kasiem, Annelieke Pasma, Jolanda J Luime, Ilja Tchetverikov, Kim Wervers, Lindy-Anne Korswagen, Natasja Denissen, Yvonne P M Goekoop-Ruiterman, Maikel van Oosterhout, Faouzia Fodili, Johanna M W Hazes, Martijn B A van Doorn, Marc R Kok, Marijn Vis
Rheumatologists play a pivotal role in the management of patients with Psoriatic Arthritis (PsA). Due to time constraints, the skin may not receive the attention that is needed for optimal patient outcome. Therefore, the aim of this study was to select a set of core questions that can help rheumatologists to identify PsA patients with a high skin burden in daily rheumatology clinical practice.
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Mammalian Target of Rapamycin Pathway Assessment in Antiphospholipid Antibody Positive Patients with Livedo. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Ecem Sevim, Salma Siddique, Madhavi Latha S Chalasani, Susan Chyou, William Shipman, Orla O'Shea, Joanna Harp, Oral Alpan, Stéphane Zuily, Theresa Lu, Doruk Erkan
In antiphospholipid antibody (aPL) nephropathy, activation of the mammalian target of rapamycin (mTOR) contributes to endothelial cell proliferation, a key finding of aPL microvascular disease. Here, we examined mTOR activation in the skin of aPL-positive patients with livedo.
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Active Disease in Psoriatic Arthritis: An Assessment of Spondyloarthritis International Society Health Index (ASAS-HI)-based Analysis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Rubén Queiro, Isla Morante, Ignacio Braña
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that affects one-third of patients with psoriasis (PsO). PsA is a relatively common condition in rheumatology clinics. In fact, the prevalence of PsA increased to approximately 0.6% of the general population in a recent epidemiological study carried out in Spain.1.
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The role of sural nerve biopsy in diagnosis of vasculitis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Karl Gisslander, Lars B Dahlin, Rona Smith, David Jayne, Dominic G O'Donovan, Aladdin J Mohammad
The diagnostic yield of sural nerve biopsy (SNB) in vasculitis is uncertain. Our aim was to document relevant characteristics of patients undergoing sural nerve biopsy in the investigation of vasculitis; determine the diagnostic yield; relate positive biopsy findings to patient demographic, laboratory, and clinical parameters; and to calculate the rate of surgical complications.
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Correlation of fibromyalgia survey questionnaire and quantitative sensory testing among patients with active rheumatoid arthritis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Meriah N Moore, Beth I Wallace, Jing Song, Lutfiyya N Muhammad, Andrew C Heisler, Daniel J Clauw, Marcy B Bolster, Wendy Marder, Tuhina Neogi, Alyssa Wohlfahrt, Dorothy D Dunlop, Yvonne C Lee
Patients with rheumatoid arthritis (RA) commonly demonstrate disordered pain processing, associated with high pain sensitization. Pain sensitization is often assessed using quantitative sensory testing (QST), which is burdensome to patients. The self-administered fibromyalgia survey questionnaire (FSQ) has been proposed as a low-burden, surrogate measure of central pain sensitization. We examined the
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The Use of Mobile Health Apps in Clinical Practice Remains Challenging. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Astrid van Tubergen, Kasper Hermans
According to several international recommendations, disease activity should be regularly monitored with validated outcome measures in patients with axial spondyloarthritis (axSpA), and therapy should be adapted accordingly.1-3 Increasingly, healthcare providers are encouraged to also use patient-reported outcomes (PROs) for this purpose, to capture valuable data from the patient's perspective.
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Development of an Item Bank for a health-related quality of life Measure in Spondyloarthritis. J. Rheumatol. (IF 5.346) Pub Date : 2022-06-01 Yu Heng Kwan, Warren Fong, Ting Hui Woon, Jie Kie Phang, Kelly Png, Jia Qi Lau, Ying Ying Leung, Chuen Seng Tan, Truls Østbye, Julian Thumboo
Health-related quality of life (HRQOL) is an important aspect in the management of chronic diseases such as spondyloarthritis (SpA). A promising approach to reduce respondent burden when measuring HRQOL is the use of shorter patient-reported outcome measures (PROMs) delivered using computer-adaptive tests (CATs). However, the lack of an item bank which covers the entire continuum of the HRQOL domain