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Bridging the Gap: Assessing Nephrology Transition Practices in Pediatric and Adult Medical Centers Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2025-02-05 Andrew Vissing, Priya S Verghese, Angelina Dixon, Cybele Ghossein
cols in academic medical centers, however, is currently unknown. Methods: General nephrology and transplant nephrology programs were surveyed at both pediatric and adult medical centers to explore the current state of nephrology transition practices. Programs without transition clinics were asked to identify obstacles preventing the establishment of a transition clinic. Results: Overall, there were
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Sex and Gender in Science, Medicine, and Nephrology: Where Are We and Why Does It Matter? Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2025-02-05 Farah Wehbe, Adeera Levin
An abstract is unavailable. This article is available as a PDF only.
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Effects of Clazakizumab on Anemia and Iron Metabolism in Patients with Kidney Failure. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-05 Brendon L Neuen,Benjamin Catanese,Annamarie Chang,Mark Heise,Pierluigi Tricoci,G Michael Felker,Kenneth W Mahaffey,Myles Wolf,Glenn M Chertow,
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Publisher Correction: Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2025-02-04 Dieter Haffner, Francesco Emma, Lothar Seefried, Wolfgang Högler, Kassim M. Javaid, Detlef Bockenhauer, Justine Bacchetta, Deborah Eastwood, Martin Biosse Duplan, Dirk Schnabel, Philippe Wicart, Gema Ariceta, Elena Levtchenko, Pol Harvengt, Martha Kirchhoff, Oliver Gardiner, Federico Di Rocco, Catherine Chaussain, Maria Luisa Brandi, Lars Savendahl, Karine Briot, Peter Kamenický, Lars Rejnmark, Agnès
Correction to: Nature Reviews Nephrology https://doi.org/10.1038/s41581-024-00926-x, published online 15 January 2025.
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Why Is C5a Inflammatory Complement Inhibition Not Enough to Improve C3 Glomerulopathy? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-04 Peter F Zipfel,Christine Skerka
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Increasing the Removal of Large Solutes by Kidney Replacement Therapy. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-04 Timothy W Meyer
Solutes that accumulate when the kidneys fail range in size from about 40 to 40,000 Da. Their dialytic clearance tends to decrease as their size increases. Disproportionate accumulation of large solutes has therefore long been considered a potential contributor to residual illness in dialysis patients. Early efforts focused on the removal of "middle molecules" with mass from 300 to 2000 Da. The identification
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Artificial intelligence approaches to enable early detection of CKD Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2025-02-03 Navdeep Tangri, Charumathi Sabanayagam
The late diagnosis of chronic kidney disease (CKD) is a global problem that limits the opportunity to initiate disease-modifying therapies. Artificial intelligence approaches using imaging or laboratory-based models can facilitate the early detection and risk stratification of CKD and thereby enable optimal treatment to reduce the burden of the disease.
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Genotype-Based Molecular Mechanisms in Alport Syndrome. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-03 Emine Bilge Caparali,Vanessa De Gregorio,Moumita Barua
Alport syndrome (AS) is an inherited disorder characterized by kidney disease, sensorineural hearing loss and ocular abnormalities. AS is caused by pathogenic variants in COL4A3, COL4A4 or COL4A5, which encode the α3, α4 and α5 chains of type IV collagen that forms a heterotrimer expressed in the glomerular basement membrane. Knowledge of its genetic basis has informed the development of different
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Characterization of the Cystic Phenotype Associated with Monoallelic ALG8 and ALG9 Pathogenic Variants. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-03 Tabinda Jawaid,Doaa E Elbarougy,Sravanthi Lavu,Guillaume Buia,Sarah R Senum,Eric Olinger,Hana Yang,Shannon K McDonnell,Joshua T Bublitz,Jun Ma,Marie-Pierre Audrézet,Charles D Madsen,Rachel S Schauer,Tracy A Baker,Adriana V Gregory,Sarah G Orr,Miguel Barroso-Gil,Ruxandra Neatu,Giancarlo Joli,Neera K Dahl,Timothy L Kline,Valentine Gillion,Karin Dahan,Francois Jouret,Ronald D Perrone,Theodore I Steinman
BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD) is a common, inherited nephropathy often resulting in kidney failure. It is genetically heterogeneous; along with the major genes, PKD1 and PKD2, at least 8 others have been suggested. ALG8 pathogenic variants have been associated with autosomal dominant polycystic liver disease and implicated in ADPKD, while ALG9 has been suggested as
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What Are Baskets, Umbrellas, and Platforms Doing in Nephrology Clinical Trials? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-02-03 Julie Lin,Jai Radhakrishnan
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Performance of Creatinine and Cystatin-Based Equations on Estimating Measured Glomerular Filtration Rate in People with Hematological and Solid Cancers Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2025-01-28 Silvia M Titan, John C Lieske, Jeffrey W Meeusen, Stacy Thorson, Yi Lin, Grzegorz S Nowakowski, Jason N Barreto, Erin F Barreto, Kathryn J Ruddy, Nelson Leung, Andrew D Rule, Sandra M Herrmann
ine and cystatin C-based equations in comparison to measured GFR (mGFR) in people with cancer. Methods: We retrieved data for all adult patients who had mGFR by urinary iothalamate clearance between 2011 and 2023 at Mayo Clinic and use of an electronic health record diagnosis code for cancer within two years prior to mGFR. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), European Kidney
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Impact of Race on Transplantation in Autosomal Dominant Polycystic Kidney Disease Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2025-01-28 Sambhavi Krishnamoorthy, Niveditha Girimaji Satishchandra, Arlene Chapman, Rita McGill
ined long-term outcomes of ADPKD-ESKD patients by self-reported race, with attention to the trajectory of Estimated Post-Transplant Survival (EPTS) scores over time. Methods: United Network for Organ Sharing Standard Transplant Analysis and Research files were used to identify 32,611 ADPKD transplant recipients between 1/2000-12/2022. EPTS scores were calculated from the date of waitlisting until transplantation
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Health Equity and Artificial Intelligence in Nephrology Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2025-01-28 Adam Engel Hercz, Susanne B. Nicholas, Alex A. T. Bui, Keith C. Norris
An abstract is unavailable. This article is available as a PDF only.
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Favourable Living Donor Kidney Transplantation Outcomes within a National Kidney Exchange Program: A Propensity Score Matching Analysis. Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2025-01-29 Stijn C. van de Laar, Annelies E. de Weerd, Frederike J. Bemelman, Mirza M. Idu, Aiko P.J. de Vries, Ian P.J. Alwayn, Stefan P. Berger, Robert A. Pol, Arjan D. van Zuilen, Raechel J. Toorop, Luuk B. Hilbrands, Paul P. Poyck, Maarten H.L. Christiaans, Jorinde H.H. van Laanen, Jacqueline van de Wetering, Hendrikus J.A.N. Kimenai, Marlies E.J. Reinders, Robert J. Porte, Frank J.M.F. Dor, Robert C. Minnee
t outcomes and risk factors for both KEP and non-KEP living donor kidney transplants. Methods: All LDKTs performed in the Netherlands between 2004-2021 were included. The primary outcome measures were one-, five- and 10-year death censored graft survival (DCGS). The secondary outcome measures were delayed graft function (DGF), graft function, rejection rates and patient survival. We used a propensity
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Treatment of patients with IgA nephropathy: a call for a new paradigm Kidney Int. (IF 14.8) Pub Date : 2025-01-31 Jürgen Floege, Amelie Bernier-Jean, Jonathan Barratt, Brad Rovin
IgA nephropathy (IgAN), the world’s most common primary glomerular disease, carries a significant lifetime risk for kidney failure as well as an enormous socioeconomic burden. In the past, studies in patients with IgAN largely focused on optimizing so-called supportive care, that is, blockade of the renin-angiotensin system, blood pressure control, and lifestyle modifications. The effectiveness of
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Genome-Wide Association Study of Plasma Sodium Concentrations with and without Exposure to Thiazide Diuretics. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-31 Niklas Worm Andersson,Xiaoping Wu,Frank Geller,Jan Wohlfahrt,Mads Melbye,Anders Hviid,Michael Schwinn,Christina Mikkelsen,Joseph Dowsett,Mie Topholm Bruun,Bitten Aagaard,Henrik Ullum,Christian Erikstrup,Daniel Fannar Gudbjartsson,Kári Stefánsson,Jonas Ghouse,Ole Birger Pedersen,Erik Sørensen,Sisse Rye Ostrowski,Henning Bundgaard,Marie Lund,Bjarke Feenstra,
BACKGROUND Abnormal plasma sodium concentration represents an imbalance of total body water relative to electrolyte content. Hyponatremia is a common and potentially severe adverse event, and thiazide diuretics constitute a leading cause of drug-induced hyponatremia. METHODS We conducted genome-wide association study analyses of plasma sodium concentration, thiazide-induced decrease in sodium concentration
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Authors' Reply: Competing Risk Models Should Be Considered When Estimating Kidney Allograft Failure. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-31 Agathe Truchot,Marc Raynaud,Alexandre Loupy
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Pathogenesis of Organ Damage in Fabry Disease: The AGALopathy Pathogenetic Pathway. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-31 Paula Rozenfeld,Sandro Feriozzi
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Competing Risk Models Should Be Considered When Estimating Kidney Allograft Failure. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-31 Jan H Lindeman,Hein Putter,Ian P J Alwayn,Esther Bastiaannet
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Association of Urinary Prostaglandin E2 with Plasma Potassium in Patients with Chronic Kidney Disease and the General Population Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2025-01-31 Frank Geurts, Martin Gritter, Dominique M. Bovée, Rosa D. Wouda, Liffert Vogt, Layal Chaker, Robert A. Fenton, Ewout J. Hoorn
An abstract is unavailable. This article is available as a PDF only.
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The Kinetics of Cystatin C and Serum Creatinine in Acute Kidney Injury Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2025-01-31 Levi Hooper, Michael Heung, Michael Kenes, Kathleen A. Stringer, Bruce Mueller, Manjunath P. Pai
ent. Serum cystatin C (sCys) has characteristics that can overcome the limitations of sCr, but head-to-head comparisons of these biomarkers is difficult to study prospectively. A quantitative assessment of the kinetics of sCys and sCr during AKI is necessary to support clinical workflow implementation for AKI diagnosis and management. Methods: A quantitative systems pharmacology (QSP) model was developed
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The kidney harbours a microbiota that may influence lithogenesis Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2025-01-30 Ellen F. Carney
A new study provides evidence of an antibiotic-responsive kidney microbiota that may influence the formation of kidney stones. Jose Agudelo and colleagues identified bacteria in mouse kidney samples, with a higher density in the medulla than in the cortex. Using RNA fluorescence in situ hybridization analysis, they also found bacterial DNA in human kidney samples; species richness was greater in the
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Risk-directed management of chronic kidney disease Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2025-01-30 Matthew F. Blum, Brendon L. Neuen, Morgan E. Grams
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Autoantibodies in the Pathogenesis of Podocytopathies. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-30 Lukas Blume,Catherine Meyer-Schwesinger
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KidneyintelX.dkd: An Innovation in Precision Medicine for Diabetic Kidney Disease. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-30 Steven G Coca,Girish N Nadkarni
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Anti-slit Antibodies against Podocin and Kirrel1 in Pediatric and Adult Podocytopathies. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-30 Valentina Raglianti,Maria Lucia Angelotti,Letizia De Chiara,Marco Allinovi,Luigi Cirillo,Anna Manonelles Montero,Josep Maria Cruzado,Maria Elena Melica,Giulia Antonelli,Carolina Conte,Anna Julie Peired,Laura Lasagni,Bärbel Lange-Sperandio,Hans-Joachim Anders,Francesca Becherucci,Elena Lazzeri,Benedetta Mazzinghi,Paola Romagnani
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Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula via YAP1 Signaling. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-30 Yongdong Wu,Tae Hoon Lee,Owen H Cheng,Eric Peden,Qingtian Li,Jun Wang,Fengzhang Huang,Marites P Melancon,David Sheikh-Hamad,Tao Wang,Luan Truong,William Mitch,Ming Liang,Jizhong Cheng
BACKGROUND Arteriovenous (AV) fistulas are the preferred access for dialysis but have a high incidence of failure. This study aims to understand the crosstalk between skeletal muscle catabolism and AV fistula maturation failure. METHODS Skeletal muscle metabolism and AV fistula maturation were evaluated in mice with chronic kidney disease (CKD). The roles of myostatin and YAP1 in regulating the transdifferentiation
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Revisiting Protein Restriction in Early CKD: Did We Get it Wrong? Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-30 Biruh T Workeneh,Linda W Moore,William E Mitch
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Surveying the Medical Education Landscape: Perspectives on Nephrology Education Among Internal Medicine Residents. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-30 Christina L Tamargo,C John Sperati,Christiana M Zhang,Paul D O'Rourke,Stephen M Sozio
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The End Stage Kidney Disease Discussion of Patient Life Goals Survey. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-30 Claudia Dahlerus,Noelle E Carlozzi,Jonathan H Segal,Joseph M Messana
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In Reply to "The End Stage Kidney Disease Discussion of Patient Life Goals Survey". Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-30 Samantha L Gelfand
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Machine Perfusion in Deceased Donor Kidney Transplantation: Promises of Improved Outcomes But Gaps in Implementation. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-30 Elizabeth M Sonnenberg,James F Markmann
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Loss of B cell protection in uraemic kidney disease Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2025-01-29 Monica Wang
The mechanisms that drive impaired immunity in people with kidney disease remain unclear. A study by Partha Biswas and colleagues now links a uraemic toxin to defective germinal centre (GC) B cell responses in mice. Gene-expression analysis and cell staining suggested reduced proliferation and increased apoptosis in GC B cells from KD mice compared with controls. In vitro, exposing plasmablasts to
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Insights into the burden of CKDu Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2025-01-28 Susan J. Allison
Chronic kidney disease of undetermined cause (CKDu) is a progressive form of chronic kidney disease (CKD) that is not associated with common risk factors for CKD and mainly affects adults in low- and middle-income countries (LMICs). Researchers from the disadvantaged populations estimated glomerular filtration rate (eGFR) epidemiology (DEGREE) study now report initial insights into the burden of CKDu
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MAIT Cell-Mediated Immune Mechanisms of Dialysis-Induced Peritoneal Fibrosis and Therapeutic Targeting. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-28 Yuxiang Sun,Qiang Huang,Juan Sun,Hu Zhou,Dandan Guo,Long Peng,Hongchun Lin,Canming Li,Hongli Shang,Tongtong Wang,Yanxu Chen,Yong Huang,Cheng Hu,Zhaoyong Hu,Yan Lu,Hui Peng
BACKGROUND Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD) and abdominal surgeries, yet effective treatments remain elusive. Given the known roles of mucosal-associated invariant T (MAIT) cells in immune responses and fibrotic diseases, we investigated their involvement in PD-induced peritoneal fibrosis to identify potential therapeutic targets. METHODS We employed
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Mechanotransduction and the Integrity of the Slit Diaphragm. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-28 Rose Z Hill
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Integrin Trafficking, Fibronectin Architecture, and Glomerular Injury upon AdipoR1 Depletion. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-28 Sonja Lindfors,Constanze Schmotz,Dominik Lewandowski,Annika Hau,Leena Saikko,Eero Lehtonen,Ville Majaniemi,Minna Karhe,Jette-Britt Naams,Harry Nisen,Jukka Tienari,Moin A Saleem,Katharina Pfeil,Heiko Bugger,Kirsi H Pietiläinen,Tuomas Mirtti,Krzysztof Palczewski,Sanna Lehtonen
BACKGROUND Deficiency of adiponectin and its downstream signaling may contribute to the pathogenesis of kidney injury in type 2 diabetes. Adiponectin activates intracellular signaling via adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2), but the role of AdipoR-mediated signaling in glomerular injury in type 2 diabetes remains unknown. METHODS The expression of AdipoR1 in the kidneys of people with
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Testing Interventions that Address Kidney Health Disparities. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-12-23 Keisha Bentley-Edwards,LáShauntá Glover,Amber E Johnson,Dinushika Mohottige,Joy E Obayemi,Stefany Olague,Melvin Thompson,Sri Lekha Tummalapalli,Megan Urbanski,Huiman Barnhart,Christina M Wyatt,
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Kaposi sarcoma and its rare presentation in a kidney transplant recipient. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Zeynep Dilara Selcuk,Dilek Barutcu Atas,Gizem Menetlioglu,Volkan Dericioglu,Ebru Asicioglu,Serhan Tuglular,Arzu Velioglu
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Amelogenesis imperfecta in familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Inès Vanderheyden,Adeline Jacquinet,Vinciane Dideberg,François Jouret
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Kidney function as a predictor of relapse in ANCA-associated vasculitis. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Khin Zar Li Lwin,Shi Yun Tan,Cynthia C Lim
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The Case | A rare cause of acute kidney injury and proteinuria. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Siarhei Dzedzik,Frank Cortazar,Dominick Santoriello
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Filgrastim-associated extramedullary hematopoiesis in the allograft kidney. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Miroslav Sekulic,Joseph U Singh
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The mitochondrial choline transporter, SLC25A48, regulates urine and blood choline levels in humans. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Soumya Maity,Kumar Sharma
Choline is an essential nutrient for the biosynthesis of phospholipids and neurotransmitters and controls several physiological functions in mammals. It is metabolized in the organelles within cells, including mitochondria. However, its subcellular distribution and mode of mitochondrial transport remain poorly understood. Patil et al. identified SLC25A48 as a mitochondrial choline transporter, and
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KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Vicente E Torres,Curie Ahn,Thijs R M Barten,Godela Brosnahan,Melissa A Cadnapaphornchai,Arlene B Chapman,Emilie Cornec-Le Gall,Joost P H Drenth,Ron T Gansevoort,Peter C Harris,Tess Harris,Shigeo Horie,Max C Liebau,Michele Liew,Andrew J Mallett,Changlin Mei,Djalila Mekahli,Dwight Odland,Albert C M Ong,Luiz F Onuchic,York P-C Pei,Ronald D Perrone,Gopala K Rangan,Brian Rayner,Roser Torra,Ethan M Balk
The Kidney Disease: Improving Global Outcomes (KDIGO) 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) represents the first KDIGO guideline on this subject. Its scope includes nomenclature, diagnosis, prognosis, and prevalence; kidney manifestations; chronic kidney disease (CKD) management and progression, kidney
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Do the Cil/Dex/H-Dot nanoparticles possess potential anti-inflammatory effects? Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Heng Wang,Keyi Fan,Honglin Dong,Guoping Zheng
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Can you have a cake and eat it? Comparing reducing mycophenolate versus switching to everolimus for kidney transplants with new-onset BKPyV-DNAemia. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Hans H Hirsch
BK polyomavirus remains a vexing issue in kidney transplantation. There are no antiviral drugs, and solely reducing immunosuppression is recommended for management. However, evidence from randomized controlled studies lacks defining clearance of BK polyomavirus-DNAemia and/or nephropathy as a primary outcome. In this arena of strong opinions, hesitancy, and poor industry interest, Caillard et al. from
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When two signals cross paths: cGAS-STING and ER stress in kidney disease progression. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Ryo Yamada,Motoko Yanagita
Previous reports have suggested that both the endoplasmic reticulum (ER) stress and cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathways contribute to the progression of chronic kidney disease; however, the relationship between these 2 pathways in kidney injury has not been fully elucidated. Andrade-Silva et al. revealed that the cyclic guanosine
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Shaking it off: loss of NHE3-mediated calcium reabsorption is compensated by the distal nephron. Kidney Int. (IF 14.8) Pub Date : 2025-02-01 Emma H Ulrich,R Todd Alexander
Sodium reabsorption is tightly coupled to calcium reabsorption in the proximal tubule via the action of the Na+/H+ exchanger isoform 3 (NHE3). Poulsen et al. provide evidence of reduced proximal calcium reabsorption in kidney tubule-specific NHE3-deficient mice that is compensated distally, unaltered phosphate homeostasis, and NHE3 involvement in the hypocalciuric effect of thiazides. These results
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Tubular Epithelial Cells are the Genetic Epicenter for Kidney Function. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-24 Cassianne Robinson-Cohen,Joachim H Ix
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Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies. Kidney Int. (IF 14.8) Pub Date : 2025-01-23 Bohan Chen,Mengxuan Chen,Mingyang Chang,Yan Ge,William Gunning,Ragheb Assaly,Lance D Dworkin,Ying Jin Qiao,Rujun Gong
Melanocortin therapeutics, exemplified by adrenocorticotropic hormone, have a proven steroidogenic-independent anti-proteinuric and glomerular protective effect. The biological functions of melanocortins are mediated by melanocortin receptors (MCR), including MC1R, which recent studies have shown to protect against glomerular disease. However, the role of other MCRs like MC5R is unknown. Here, MC5R
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Many strategies enabling us to optimize kidney care may also be planet-friendly. Kidney Int. (IF 14.8) Pub Date : 2025-01-23 Piccoli Giorgina Barbara,Garcia-Garcia Guillermo,Salomone Mario,Chavez-Iñiguez Jonathan Samuel,Gómez-Fregoso Juan Alberto,Torreggiani Massimo
Kidney replacement therapy (KRT) is one of the most energy-consuming and waste-producing medical treatments. Reducing the need of dialysis is therefore an environmentally friendly choice. However, preferring prevention, lifestyle-related interventions and patient education to drugs is time consuming and most physicians are already overburdened by the many demands of routine clinical practice. In this
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Six-month safety and efficacy outcomes from the randomized-controlled arm of the WRAPSODY Arteriovenous Access Efficacy (WAVE) trial. Kidney Int. (IF 14.8) Pub Date : 2025-01-23 Mahmood K Razavi,Saravanan Balamuthusamy,Angelo N Makris,Jeffrey G Hoggard,Leonardo O Harduin,Prabir Roy-Chaudhury,Robert G Jones,
Stenosis within the arteriovenous fistula (AVF) of hemodialysis patients leads to vascular access dysfunction and inadequate hemodialysis. Percutaneous transluminal angioplasty (PTA) is the standard therapy for stenosis. However, rates of restenosis and loss of access patency remain high. Outcomes of a novel cell-impermeable endoprosthesis (CIE) have not been investigated in this setting. Therefore
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N-acetyl-tryptophan in Acute Kidney Injury after Cardiac Surgery. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-23 Ning Shi,Ji-Wen Wang,Gengchen Su,Gaoxiang Ma,Feng-Qing Huang,Si-Jia Jin,Hua-Mei Xie,Wen-Xin Ge,Jiang-Ping Song,Xiaodong Luan,Lei Zhang,Lian-Wen Qi
BACKGROUND Cardiac surgery-associated acute kidney injury is a common serious complication after cardiac surgery. Currently, there are no specific pharmacological therapies. Our understanding of its pathophysiology remains preliminary. METHODS A total of 2504 patients with and without acute kidney injury (AKI) following cardiac surgery were enrolled. High-performance liquid chromatography coupled with
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Tuberculosis in the US Kidney Failure Population. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2025-01-23 Kimberly R Schildknecht,Molly Deutsch-Feldman,Jason Cummins,Divia P Forbes,Maryam B Haddad,Ibironke W Apata,Jonathan M Wortham
BACKGROUND People with chronic kidney disease (CKD) have a higher risk for progression to tuberculosis disease following infection with Mycobacterium tuberculosis. We produced a nationwide incidence estimate and description of tuberculosis among people with kidney failure. METHODS We completed a cross-sectional descriptive analysis of people with a reported case of tuberculosis in the United States
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Renal Tubular Acidosis: Core Curriculum 2025. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-23 Ryan Bonner,Gerald Hladik
Renal tubular acidoses (RTAs) are a subset of non-anion gap metabolic acidoses that result from complex disturbances in renal acid excretion. Net acid excretion is primarily accomplished through the reclamation of sodium bicarbonate and the buffering of secreted protons with ammonia or dibasic phosphate, all of which require a series of highly complex and coordinated processes along the renal tubule
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Development of a Patient Reported Outcome Measure of Side Effects for Patients Taking Calcineurin Inhibitors: The FACIT-CNI-Ntx. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-23 Courtney N Hurt,George J Greene,John Friedewald,Amy D Waterman,Daniela Ladner,Xiaodan Tang,Kevin Fowler,Karen Kaiser,David Cella,John Devin Peipert
RATIONALE & OBJECTIVE Valid measures of side effects are important to inform clinical use of calcineurin inhibitors (CNIs). This study sought to develop and establish the content validity of a PRO measure to capture side effects among kidney transplant recipients taking CNIs. STUDY DESIGN Qualitative interviews for concept elicitation and cognitive debriefing. SETTING & PARTICIPANTS Participants enrolled
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Differences in Postoperative Disposition by Kidney Disease Severity: A Population-Based Cohort Study. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-23 Tyrone G Harrison,Tayler D Scory,Brenda R Hemmelgarn,Mary E Brindle,Oluwatomilayo O Daodu,Michelle M Graham,Matthew T James,Ngan N Lam,Pavel Roshanov,Khara M Sauro,Paul E Ronksley
RATIONALE & OBJECTIVE People with advanced kidney disease undergo more non-cardiac operations compared to the general population, with a higher risk of perioperative cardiac events and death. However, little is known about the associations between severity of preoperative kidney dysfunction with postoperative length of hospitalization and discharge disposition; these were the focus of this study. STUDY
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Arterial Stiffness and Subsequent Incidence of CKD and Kidney Function Decline in a Large Longitudinal Community Cohort: The Atherosclerosis in Communities (ARIC) Study. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2025-01-23 Zhiqi Yao,Junichi Ishigami,Esther Kim,Shoshana H Ballew,Yingying Sang,Hirofumi Tanaka,Michelle L Meyer,Josef Coresh,Kunihiro Matsushita
RATIONALE & OBJECTIVE Arterial stiffness is associated with prevalent chronic kidney disease (CKD). Whether arterial stiffness is prospectively associated with incident CKD is inconclusive. STUDY DESIGN Longitudinal cohort study. SETTING & PARTICIPANTS Using data from the Atherosclerosis Risk in Communities (ARIC) Study, the primary analysis included 3,161 participants without prevalent CKD at visit