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What can we learn from kidney organoids? Kidney Int. (IF 18.998) Pub Date : 2022-08-13 Aude Dorison, Thomas A. Forbes, Melissa H. Little
The ability to generate 3D models of the developing human kidney via the directed differentiation of pluripotent stem cells – termed kidney organoids - has been hailed as a major advance in experimental nephrology. While these provide an opportunity to interrogate human development, model specific kidney diseases, facilitate drug screening and even deliver bioengineered tissue, most of these prophetic
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Correction of Hypokalemia in Peritoneal Dialysis Patients May Decrease Peritonitis Risk Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-13 Beth M. Piraino
Abstract not available
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Clinical Trial Considerations in Developing Treatments for Early Stages of Common, Chronic Kidney Diseases: A Scientific Workshop Cosponsored by the National Kidney Foundation and the US Food and Drug Administration Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-13 Lesley A. Inker, Morgan E. Grams, Hrefna Guðmundsdóttir, Phil McEwan, Robert Friedman, Aliza Thompson, Daniel E. Weiner, Kerry Willis, Hiddo J.L. Heerspink
In the past decade, advances in the validation of surrogate end points for chronic kidney disease (CKD) progression have heightened interest in evaluating therapies in early CKD. In December 2020, the National Kidney Foundation sponsored a scientific workshop in collaboration with the US Food and Drug Administration (FDA) to explore patient, provider, and payor perceptions of the value of treating
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Adult-Onset Focal Segmental Glomerulosclerosis With Steroid-Dependent Nephrotic Syndrome Caused by a Novel TBC1D8B Variant: A Case Report and Literature Review Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-12 Zhengying Fang, Chunli Zhang, Yuanmeng Jin, Jun Tong, Jian Liu, Xu Hao, Qinjie Weng, Shuwen Yu, Wen Du, Yikai Cai, Qimin Zheng, Li Yang, Hong Ren, Xiaoxia Pan, Jingyuan Xie
Focal and segmental glomerulosclerosis (FSGS) is a histological lesion due to many causes including rare mutations of podocyte related genes. Recently, it has been found that TBC1D8B mutations can lead to early-onset FSGS and steroid-resistant nephrotic syndrome (NS) by influencing endocytic and recycling of nephrin. Here, we report a 19-year-old Chinese patient with NS and normal renal function. He
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Calciphylaxis and Kidney Disease: A Review Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-12 Benjamin Gallo Marin, Ghazal Aghagoli, Susie L. Hu, Cathy M. Massoud, Leslie Robinson-Bostom
Calciphylaxis is a life-threatening complication most often associated with chronic kidney disease that occurs due to the deposition of calcium in dermal and adipose microvasculature. However, this condition may also be seen in patients with acute kidney injury. The high morbidity and mortality associated with calciphylaxis highlight the importance to correctly diagnose and treat this condition. However
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KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-12 Gyuyeong Rah, Hwayeon Cha, Joohee Kim, Jieun Song, Hyunho Kim, Yun Kyu Oh, Curie Ahn, Minyong Kang, Jongmin Kim, Kyung Hyun Yoo, Min Jung Kim, Hyuk Wan Ko, Je Yeong Ko, Jong Hoon Park
Background Ciliogenesis-associated kinase 1 (CILK1) is a ciliary gene that localizes in primary cilia and regulates ciliary transport. Mutations in CILK1 cause various ciliopathies. However, the pathogenesis of CILK1-deficient kidney disease is unknown.Methods To examine whether CILK1 deficiency causes PKD accompanied by abnormal cilia, we generated mice with deletion of Cilk1 in cells of the renal
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Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins Leading to Secondary Hyperparathyroidism J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-12 Alia Hassan, Yael E. Pollak, Rachel Kilav-Levin, Justin Silver, Nir London, Morris Nechama, Iddo Z. Ben-Dov, Tally Naveh-Many
Background Secondary hyperparathyroidism (SHP) is a common complication of CKD that increases morbidity and mortality. In experimental SHP, increased parathyroid hormone (PTH) expression is due to enhanced PTH mRNA stability, mediated by changes in its interaction with stabilizing AUF1 and destabilizing KSRP. The isomerase Pin1 leads to KSRP dephosphorylation, but in SHP parathyroid Pin1 activity is
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Incidence and Risk Factors for Dialysis Reinitiation among Patients with a History of Dialysis Dependency Clin. J. Am. Soc. Nephrol. (IF 10.614) Pub Date : 2022-08-11 Elaine Ku, Raymond K. Hsu, Charles E. McCulloch, Lowell Lo, Timothy Copeland, Salpi Siyahian, Barbara Grimes, Kirsten L. Johansen
Background and objectives Recovery of kidney function after the start of maintenance dialysis can occur, but data on the incidence and risk factors for restarting dialysis after recovery of kidney function in this population are limited.Design, setting, participants, & measurements We conducted a retrospective study of adult Medicare beneficiaries who started dialysis between 2005 and 2015 according
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Acute Kidney Injury in Patients Receiving Pembrolizumab Combination Therapy versus Pembrolizumab Monotherapy for Advanced Lung Cancer Kidney Int. (IF 18.998) Pub Date : 2022-08-11 Shruti Gupta, Ian A. Strohbehn, Qiyu Wang, Paul E. Hanna, Rituvanthikaa Seethapathy, Jason M. Prosek, Sandra M. Herrmann, Ala Abudayyeh, A. Bilal Malik, Sebastian Loew, Christopher A. Carlos, Wei-Ting Chang, Pazit Beckerman, Zain Mithani, Chintan V. Shah, Amanda D. Renaghan, Sophie De Seigneux, Luca Campedel, Meghan E. Sise
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The effectiveness and safety of mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines among individuals with chronic kidney diseases Kidney Int. (IF 18.998) Pub Date : 2022-08-11 Franco Wing Tak Cheng, Min Fan, Carlos King Ho Wong, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Sydney Chi Wai Tang, Esther W. Chan, Ian Chi Kei Wong
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USE OF REMDESIVIR IN KIDNEY TRANSPLANT RECIPIENTS WITH SARS-COV-2 OMICRON INFECTION Kidney Int. (IF 18.998) Pub Date : 2022-08-11 Judit Cacho, David Nicolás, Marta Bodro, Elena Cuadrado-Payán, Verónica Torres-Jaramillo, Ángela Gonzalez-Rojas, Pedro Ventura-Aguiar, Enrique Montagud-Marrahi, Sabina Herrera, Veronica Rico, Frederic Cofàn, Frederic Oppenheimer, Ignacio Revuelta, Fritz Diekmann, David Cucchiari
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Clinicopathologic and Proteomic Characteristics of Intratubular Cytoplasmic AL-Amyloidosis Kidney Int. (IF 18.998) Pub Date : 2022-08-11 Vincent Javaugue, Alejandro Best Rocha, Samar M. Said, Dominick Santoriello, Jean Hou, Surendra Dasari, Jason D. Theis, Julie A. Vrana, Ibrahim Batal, Christopher Larsen, Glen S. Markowitz, Vivette D. D'Agati, Ellen D. McPhail, Nelson Leung, Samih H. Nasr
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Integrating basic science with translational research: the 13th International Podocyte Conference 2021 Kidney Int. (IF 18.998) Pub Date : 2022-08-11 Franziska Lausecker, Sybille Koehler, Maryline Fresquet, Richard Naylor, Pinyuan Tian, Nicola Wanner, Fabian Braun, Linus Butt, Tobias B. Huber, Rachel Lennon
The 13th International Podocyte Conference was held in Manchester and Online from the 28th-30th of July 2021. Originally planned for 2020, this biannual meeting was postponed by a year due to the COVID-19 pandemic and proceeded as an innovative hybrid meeting. In addition to in-person attendance, online registration was offered, and this attracted 490 conference registrations in total. As a Podocyte
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How does diabetes cause susceptibility to COVID in the kidney: new clues provided by organoids Kidney Int. (IF 18.998) Pub Date : 2022-08-10 Yun Xia, P. Toby Coates, Masaomi Nangaku
Abstract not available
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Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis Clin. J. Am. Soc. Nephrol. (IF 10.614) Pub Date : 2022-08-10 Hannah Melchinger, Frida Calderon-Gutierrez, Wassim Obeid, Leyuan Xu, Melissa M. Shaw, Randy L. Luciano, Michael Kuperman, Gilbert W. Moeckel, Michael Kashgarian, F. Perry Wilson, Chirag R. Parikh, Dennis G. Moledina
Visual Abstract
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A polygenic score predicts CKD across ancestries Nat. Rev. Nephrol. (IF 42.439) Pub Date : 2022-08-11 Inga Steinbrenner, Anna Köttgen
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Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Mariavittoria D’Acierno, Roberta Resaz, Anna Iervolino, Rikke Nielsen, Donato Sardella, Sabrina Siccardi, Vincenzo Costanzo, Luciano D’Apolito, Yoko Suzumoto, Daniela Segalerba, Simonetta Astigiano, Alessandra F. Perna, Giovambattista Capasso, Alessandra Eva, Francesco Trepiccione
Background Mutations in SLC37A4, which encodes the intracellular glucose transporter G6PT, cause the rare glycogen storage disease type 1b (GSD1b). A long-term consequence of GSD1b is kidney failure, which requires KRT. The main protein markers of proximal tubule function, including NaPi2A, NHE3, SGLT2, GLUT2, and AQP1, are downregulated as part of the disease phenotype.Methods We utilized an inducible
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Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Lin Dang, Xinyi Cao, Tianye Zhang, Yongzhan Sun, Shanshan Tian, Tianyu Gong, Hui Xiong, Peipei Cao, Yuhao Li, Shengqiang Yu, Li Yang, Lirong Zhang, Tong Liu, Kai Zhang, Jing Liang, Yupeng Chen
Background Emerging evidence indicates that epigenetic modulation of gene expression plays a key role in the progression of autosomal dominant polycystic kidney disease (ADPKD). However, the molecular basis for how the altered epigenome modulates transcriptional responses, and thereby disease progression in ADPKD, remains largely unknown.Methods Kidneys from control and ADPKD mice were examined for
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Description and Outcomes of an Innovative Concurrent Hospice-Dialysis Program J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Natalie C. Ernecoff, Alexandra E. Bursic, Erica M. Motter, Keith Lagnese, Robert Taylor, Jane O. Schell
Background Compared with the general Medicare population, patients with ESKD have worse quality metrics for end-of-life care, including a higher percentage experiencing hospitalizations and in-hospital deaths and a lower percentage referred to hospice. We developed a Concurrent Hospice and Dialysis Program in which patients may receive palliative dialysis alongside hospice services. The Program aims
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Prognostic Implications of a Morphometric Evaluation for Chronic Changes on All Diagnostic Native Kidney Biopsies J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Aleksandar Denic, Marija Bogojevic, Aidan F. Mullan, Moldovan Sabov, Muhammad S. Asghar, Sanjeev Sethi, Maxwell L. Smith, Fernando C. Fervenza, Richard J. Glassock, Musab S. Hommos, Andrew D. Rule
Visual Abstract
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Too bright for two dimensions: recent progress in advanced three-dimensional microscopy of the kidney Kidney Int. (IF 18.998) Pub Date : 2022-08-10 Rui Santos, Max Bürgi, Jose Maria Mateos, Alessandro Luciani, Johannes Loffing
The kidney is a structurally and functionally complex organ responsible for the control of water, ion and other solutes homeostasis. Moreover, the kidneys excrete metabolic waste products and produce hormones such as renin and erythropoietin. The functional unit of the kidney is the nephron, which is composed by a serial arrangement of a filter unit called the renal corpuscle and several tubular segments
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Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology Clin. J. Am. Soc. Nephrol. (IF 10.614) Pub Date : 2022-08-09 Michael W. Holliday, Qingtian Li, Edlyn G. Bustamante, Jingbo Niu, Luping Huang, Ilse M. Espina, Jose R. Dominguez, Luan Truong, Kristy O. Murray, Lei Fan, Samaya J. Anumudu, Maulin Shah, Rebecca S.B. Fischer, Chandan Vangala, Sreedhar Mandayam, Jose Perez, Jenny S. Pan, Sehrish Ali, Ahmed A. Awan, David Sheikh-Hamad
Background and objectives The etiology of chronic kidney disease of unclear etiology, also known as Mesoamerican nephropathy, remains unclear. We investigated potential etiologies for Mesoamerican nephropathy in an immigrant dialysis population.Design, setting, participants, & measurements Migrants with Mesoamerican nephropathy kidney failure (n=52) were identified by exclusion of known causes of kidney
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Authors' Reply: Anti-Hinge Antibodies Are Likely to Be of Minor Importance. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Mårten Segelmark,Christian Kjellman
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Endopeptidase Therapy for Anti-Glomerular Basement Membrane Disease: Beware of Anti-Hinge Antibodies! J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-10 Dorin-Bogdan Borza,Pallavi Manral
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Genome-Wide Epistatic Interaction between DEF1B and APOL1 High-Risk Genotypes for Chronic Kidney Disease. Clin. J. Am. Soc. Nephrol. (IF 10.614) Pub Date : 2022-08-10 Ha My T Vy,Bridget M Lin,Faris F Gulamali,Charles Kooperberg,Mariaelisa Graff,Jenny Wong,Kirk N Campbell,Tara C Matise,Josef Coresh,Fridtjof Thomas,Alexander P Reiner,Rami Nassir,Peter F Schnatz,Tanya Johns,Steven Buyske,Christopher Haiman,Richard Cooper,Ruth J F Loos,Carol R Horowitz,Orlando M Gutierrez,Ron Do,Nora Franceschini,Girish N Nadkarni
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Kidney outcomes in patients with diabetes mellitus did not differ between individual sodium-glucose cotransporter-2 inhibitors Kidney Int. (IF 18.998) Pub Date : 2022-08-09 Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Masaomi Nangaku, Hideo Yasunaga, Issei Komuro
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Unraveling the Mysteries of CKD of Uncertain Etiology. Clin. J. Am. Soc. Nephrol. (IF 10.614) Pub Date : 2022-08-09 Pablo Garcia,Shuchi Anand
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Psychosocial Distress in Patients With Advanced CKD by Racial Group and Immigrant Status: A Canadian Cross-sectional Study Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-07 Navneet Singh, Punithan Thiagalingam, Junayd Hussain, Vishva Shah, Nathaniel Edwards, Eric Lui, Gihad Nesrallah, Charmaine E. Lok, Abdul Aziz Walele, Marta Novak, Carl E. James, Istvan Mucsi
Rationale & Objective Patients with advanced chronic kidney disease (CKD) have been reported to experience profound psychosocial distress. Other work has established that patients with CKD from marginalized populations (including individuals who on the basis of race often face racism and related discrimination, termed “racialization”) experience health care inequities. Given limited information on
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Effect of Long-term Exercise Training on Physical Performance and Cardiorespiratory Function in Adults With CKD: A Randomized Controlled Trial Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-06 Daniel E. Weiner, Christine K. Liu, Shiyuan Miao, Roger Fielding, Leslie I. Katzel, Jamie Giffuni, Andrew Well, Stephen L. Seliger
Rationale and Objective The safety and efficacy of long-term exercise training in reducing physical functional loss in older adults with advanced CKD and co-morbidity is uncertain. Study Design Multi-center, parallel group, randomized controlled trial. Settings and Participants Adults 55 years and older with CKD stage G3b-4 enrolled from centers in Baltimore and Boston. Intervention Twelve months of
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Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-04 Martin Gritter, Rosa D. Wouda, Stanley M.H. Yeung, Michiel L.A. Wieërs, Frank Geurts, Maria A.J. de Ridder, Christian R.B. Ramakers, Liffert Vogt, Martin H. de Borst, Joris I. Rotmans, Ewout J. Hoorn
Background Observational studies suggest that adequate dietary potassium intake (90–120 mmol/day) may be renoprotective, but the effects of increasing dietary potassium and the risk of hyperkalemia are unknown.Methods This is a prespecified analysis of the run-in phase of a clinical trial in which 191 patients (age 68±11 years, 74% males, 86% European ancestry, eGFR 31±9 ml/min per 1.73 m2, 83% renin-angiotensin
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Angiopoietin-2 inhibition attenuates kidney fibrosis by hindering chemokine C-C motif ligand 2 expression and apoptosis of endothelial cells. Kidney Int. (IF 18.998) Pub Date : 2022-08-04 Fan-Chi Chang, Chia-Hao Liu, An-Jie Luo, Thomas Tao-Min Huang, Ming-Hsuan Tsai, Yu-Jhen Chen, Chun-Fu Lai, Chih-Kang Chiang, Tzu-Hung Lin, Wen-Chih Chiang, Yung-Ming Chen, Tzong-Shinn Chu, Shuei-Liong Lin
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Persistent DNA damage underlies tubular cell polyploidization and progression to chronic kidney disease in kidneys deficient in the DNA repair protein FAN1. Kidney Int. (IF 18.998) Pub Date : 2022-08-02 Merlin Airik, Yu Leng Phua, Amy B. Huynh, Blake T. McCourt, Brittney M. Rush, Roderick J. Tan, Jerry Vockley, Susan L. Murray, Anthony Dorman, Peter J. Conlon, Rannar Airik
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Searching for the Risk-Benefit Profile of Higher Potassium Intake in CKD: Primum Non Nocere. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-04 Murilo Guedes,Roberto Pecoits-Filho
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Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients: ASCEND-TD: A Phase 3 Randomized, Double-Blind, Noninferiority Trial Clin. J. Am. Soc. Nephrol. (IF 10.614) Pub Date : 2022-08-02 Daniel W. Coyne, Ajay K. Singh, Renato D. Lopes, Christine K. Bailey, Tara L. DiMino, Chun Huang, Jeffrey Connaire, Anjay Rastogi, Sung-Gyun Kim, Marcelo Orias, Sapna Shah, Vickas Patel, Alexander R. Cobitz, Christoph Wanner
Background and objectives Daprodustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) being investigated for the treatment of anemia of CKD. In this noninferiority trial, we compared daprodustat administered three times weekly with epoetin alfa (epoetin) in patients on prevalent hemodialysis switching from a prior erythropoiesis-stimulating agent (ESA).Design, setting, participants
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Cellular senescence: the good, the bad and the unknown Nat. Rev. Nephrol. (IF 42.439) Pub Date : 2022-08-03 Weijun Huang, LaTonya J. Hickson, Alfonso Eirin, James L. Kirkland, Lilach O. Lerman
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Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Keri A. Drake, Christopher Chaney, Mohita Patel, Amrita Das, Julia Bittencourt, Martin Cohn, Thomas J. Carroll
Background The embryonic renal stroma consists of multiple molecularly distinct cell subpopulations, the functional significance of which is largely unknown. Previous work has demonstrated that the transcription factors YAP and TAZ play roles in the development and morphogenesis of the nephrons, collecting ducts, and nephron progenitor cells.Methods In embryonic mouse kidneys, we identified a subpopulation
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Emerging Insights into Glomerular Vascular Pole and Microcirculation J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Michael S. Goligorsky
The glomerular vascular pole is the gate for the afferent and efferent arterioles and mesangial cells and a frequent location of peripolar cells with an unclear function. It has been studied in definitive detail for >30 years, and functionally interrogated in the context of signal transduction from the macula densa to the mesangial cells and afferent arteriolar smooth muscle cells from 10 to 20 years
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Early Molecular Events Mediating Loss of Aquaporin-2 during Ureteral Obstruction in Rat J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Chih-Chien Sung, Brian Poll, Shih-Hua Lin, Adrian Murillo-de-Ozores, Chung-Lin Chou, Lihe Chen, Chin-Rang Yang, Min-Hsiu Chen, Yu-Juei Hsu, Mark Knepper
Background: Ureteral obstruction is marked by disappearance of the vasopressin-dependent water channel aquaporin-2 (AQP2) in the renal collecting duct and polyuria upon reversal. Most studies of unilateral ureteral obstruction (UUO) models have examined late time points, obscuring the early signals that trigger loss of AQP2. Methods: We performed RNA-Seq on microdissected rat cortical collecting ducts
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Ensuring Equitable Access to Dialysis: The Medicare Secondary Payer Act in Marietta Memorial Hospital Employee Health Benefit Plan v. DaVita, Inc. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-03 George Maliha,Joel D Glickman,Matthew S McCoy
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Authors' Reply: Understanding the Multiple Roles of Extracellular Histones in Mediating Endothelial Dysfunction. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-03 Lara Zafrani,Marine Arnaud,Nuala Mooney
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Understanding the Multiple Roles of Extracellular Histones in Mediating Endothelial Dysfunction. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-03 Tinghang Yang,Yupei Li,Baihai Su
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The Potential for Pragmatic Trials to Reduce Racial and Ethnic Disparities in Kidney Disease. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-03 Laura M Dember
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Proliferative Glomerulonephritis With Hidden Monotypic IgG3κ Deposits: A Case Report Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-02 Satoru Kudose, Ibrahim Batal, John Lucia, Purvi Patel, Rajesh K. Soni, Glen S. Markowitz, Vivette D. D’Agati, M. Barry Stokes
Rare cases of IgG-dominant immune complex mediated GN (ICGN) demonstrate immunoglobulin (Ig) subclass restriction without light chain restriction. Some of these cases may represent proliferative glomerulonephritis with monotypic immunoglobulin deposits (PGNMID) in which monotypic Ig is obscured by coexisting polytypic Ig. However, rigorous demonstration of this possibility is lacking to date. Here
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Vitamin D and Parathyroid Hormone Levels in CKD Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-02 Sangeet Dhillon-Jhattu, Rita L. McGill, Jennifer L. Ennis, Elaine M. Worcester, Anna L. Zisman, Fredric L. Coe
Abstract not available
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Prednisone for Steroid-Sensitive Nephrotic Syndrome: Can We Use Lower Doses for the First Presentation in Children? Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-01 Elisabeth Hodson, Deirdre Hahn, Jonathan C. Craig
Abstract not available
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Dying of Cancer With Kidney Disease Am. J. Kidney Dis. (IF 11.072) Pub Date : 2022-08-01 Jeremy R. Chapman
Abstract not available
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Survey of Salary and Job Satisfaction of Transplant Nephrologists in the United States Clin. J. Am. Soc. Nephrol. (IF 10.614) Pub Date : 2022-08-01 Neeraj Singh, Mona D. Doshi, Jesse D. Schold, Luke Preczewski, Christina Klein, Enver Akalin, Nicolae Leca, Kimberly Nicoll, Todd Pesavento, Darshana M. Dadhania, John Friedewald, Milagros Samaniego-Picota, Roy D. Bloom, Alexander C. Wiseman
Background and objectives There are no standardized benchmarks to measure productivity and compensation of transplant nephrologists in the United States, and consequently, criteria set for general nephrologists are often used.Design, setting, participants, & measurements A web-based survey was sent to 809 nephrologists who were members of the American Society of Transplantation to gather data on measures
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Kidney disease as a medical complication of eating disorders Nat. Rev. Nephrol. (IF 42.439) Pub Date : 2022-08-02 Leah Puckett, Shoshana Mehler, Philip Mehler
Kidney disease is an underappreciated medical complication of anorexia nervosa. Further research is needed to clarify the mechanisms that drive kidney disease in patients who restrict caloric intake or engage in purging. Education and awareness are also needed, because kidney disease is often under-recognized by these patients and their clinicians.
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The Advancing American Kidney Health Initiative: Do Not Let 80% Distract Us from the Fact that We Can Do Better. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Mallika L Mendu,Scott D Bieber,Suzanne G Watnick,Daniel E Weiner
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Decorating Histones in Polycystic Kidney Disease. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Harini Ramalingam,Vishal Patel
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Response to "The Advancing American Kidney Health Initiative: The Challenge of Overcoming the Status Quo" and "The Advancing American Kidney Health Initiative: Do Not Let 80% Distract Us from the Fact that We Can Do Better". J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Robert R Quinn,Ngan N Lam,Pietro Ravani,Matthew J Oliver,Peter G Blake,Marcello Tonelli
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The Case for Prioritizing Diversity in the Transplantation Workforce to Advance Kidney Health Equity. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Thomas Butler,Lee Cummings,Tanjala Purnell
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The Advancing American Kidney Health Initiative: The Challenge of Overcoming the Status Quo. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-02 Paul T Conway,Nieltje Gedney,Shuvo Roy,William H Fissell
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How I Treat Rituximab in the Frail and Elderly with Severe ANCA-Associated Glomerulonephritis. Clin. J. Am. Soc. Nephrol. (IF 10.614) Pub Date : 2022-08-02 Silke Brix,Vladimír Tesař
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Implementation strategies for high impact nephrology trials Kidney Int. (IF 18.998) Pub Date : 2022-08-01 Donna M. Reidlinger, David W. Johnson, Jonathan C. Craig, Stephen P. McDonald, Alistair R. Mallard, Laura E. Robison, Germaine Wong, Carmel M. Hawley
Abstract not available
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Restrictive fluid therapy and high-dose vitamin C in sepsis Nat. Rev. Nephrol. (IF 42.439) Pub Date : 2022-08-01 Mark Philip Plummer, Rinaldo Bellomo
Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictive fluid therapy has no mortality benefit compared to a standard regimen in patients with septic shock, whereas the LOVIT trial reports that high-dose intravenous vitamin C might be harmful in patients with severe sepsis.
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A pathway of osmotic stress-induced necroptosis Nat. Rev. Nephrol. (IF 42.439) Pub Date : 2022-08-01 Alberto Ortiz, Ana B. Sanz
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Authors' Reply: Serum Protein-induced Tubular Injury. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Kevin Lidberg,Jonathan Himmelfarb,Edward Kelly,Shreeram Akilesh
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Polycystin-2 in the Endoplasmic Reticulum: Bending Ideas about the Role of the Cilium. J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Michael J Caplan
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Identifying Antigen-Specific T Cells in ANCA-Associated Vasculitis: A Glimpse of the Future? J. Am. Soc. Nephrol. (IF 14.978) Pub Date : 2022-08-01 Lani Shochet,A Richard Kitching