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Progression and outcomes of rare kidney diseases Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-26 Susan J. Allison
To describe kidney and patient outcomes for individuals with rare diseases in the UK, Gale and colleagues analysed data from 27,285 patients with 28 different types of rare kidney disease in RaDaR. Over a median follow-up of 9.6 years, RaDaR participants had a significantly higher 5-year cumulative incidence of kidney failure than that of 2.81 million patients with all-cause CKD (28% versus 1%; P < 0
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Applications of SGLT2 inhibitors beyond glycaemic control Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-26 Daniel V. O’Hara, Carolyn S. P. Lam, John J. V. McMurray, Tae Won Yi, Samantha Hocking, Jessica Dawson, Smriti Raichand, Andrzej S. Januszewski, Meg J. Jardine
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Post-translational modifications in kidney diseases and associated cardiovascular risk Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-25 Heidi Noels, Vera Jankowski, Stefan J. Schunk, Raymond Vanholder, Sahir Kalim, Joachim Jankowski
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Not every organ ticks the same Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-24 Khaoula Talbi, Anette Melk
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Immune mechanisms in the pathophysiology of hypertension Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-24 Bianca A. Nguyen, Matthew R. Alexander, David G. Harrison
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Considerations of sex as a binary variable in clinical algorithms Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-23 Dinushika Mohottige, Samira Farouk, Tonia Poteat, Asa Radix, Selma Feldman Witchel
Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary considerations of sex and/or gender might introduce bias due to potentially inaccurate assumptions about sex and gender-specific physiology, hormones and exposures. An equity-focused approach to sex and gender is essential when using clinical algorithms to ensure health equity across
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Calcium signalling and transport in the kidney Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-19 Alexander Staruschenko, R. Todd Alexander, Michael J. Caplan, Daria V. Ilatovskaya
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Thiazides in kidney transplant recipients: skin in the game Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-17 Steven Van Laecke
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Epithelial cell states associated with kidney and allograft injury Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-17 Christian Hinze, Svjetlana Lovric, Philip F. Halloran, Jonathan Barasch, Kai M. Schmidt-Ott
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Time is Money: Protected Time for Fellow Education Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2024-04-17 Alice M. Sheridan
An abstract is unavailable.
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The Clinical Study of Kidney Stone Disease and the Value of Specificity Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2024-04-17 Alan C. Pao, Calyani Ganesan
An abstract is unavailable.
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Did the SCORED Trial Get Extra Points for Kidney Outcomes? If So, It Is Not Obvious Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2024-04-17 Nupur Mistry, George L. Bakris
An abstract is unavailable.
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The key role of altered tubule cell lipid metabolism in kidney disease development Kidney Int. (IF 19.6) Pub Date : 2024-04-16 Lauren E. Lee, Tomohito Doke, Dhanunjay Mukhi, Katalin Susztak
Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and proteinuria, contribute to this excess lipid build-up and exacerbate kidney disease development. Recent
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Effects of SGLT2 inhibitors on cause-specific cardiovascular death in patients with chronic kidney disease: a meta-analysis of CKD progression trials Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2024-04-16 Robert A. Fletcher, William G. Herrington, Rajiv Agarwal, Kaitlin J. Mayne, Clare Arnott, Meg J. Jardine, Kenneth W. Mahaffey, Vlado Perkovic, Natalie Staplin, David C. Wheeler, Glenn M. Chertow, Hiddo J. L. Heerspink, Brendon L. Neuen
An abstract is unavailable. This article is available as a PDF only.
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NELL-1–associated membranous nephropathy linked to skin fairness cream use: insights from an Indian case series Kidney Int. (IF 19.6) Pub Date : 2024-04-12 Ranjit Narayanan, Sajeesh Sivadas, Anila Abraham Kurien
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Association of Inflammatory Bowel Disease with Incident Immunoglobulin A Nephropathy Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2024-04-11 Takashin Nakayama, Hidehiro Kaneko, Akira Okada, Yuta Suzuki, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Norihiko Takeda, Akira Fukui, Takashi Yokoo, Hideo Yasunaga, Masaomi Nangaku, Kaori Hayashi
sing a large-scale epidemiological cohort. Methods We retrospectively analyzed 4,311,393 adults enrolled in the JMDC Claims Database (previously known as the Japan Medical Data Center database), a nationwide epidemiological database in Japan. The definitions of IgA nephropathy and inflammatory bowel disease (ulcerative colitis or Crohn’s disease) were based on International Classification of Diseases-10th
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Deciphering missense coding variants with AlphaMissense Kidney Int. (IF 19.6) Pub Date : 2024-04-10 Zhicheng Pan, Chandra L. Theesfeld
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In Reply to “‘Atypical’ Anti-GBM Disease: Just Atypical, or Not Anti-GBM Disease at All?” Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-04-09 Bertrand Chauveau MD, Jean-Baptiste Gibier MD PhD, Marion Rabant MD PhD
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Implementation science: a tool to narrow know-do gap and widen equity in kidney diseases and transplantation Kidney Int. (IF 19.6) Pub Date : 2024-04-06 Ekamol Tantisattamo
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2024-04-06 Winston W.S. Fung, Valerie A. Luyckx, Katherine R. Tuttle, writing team and the World Kidney Day Joint Steering Committee
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Bridging the knowledge–practice gap in kidney care: insights from a medical student in Thailand Kidney Int. (IF 19.6) Pub Date : 2024-04-06 Abhishet Varama
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2024-04-06 Winston W.S. Fung, Valerie A. Luyckx, Katherine R. Tuttle, writing team and the World Kidney Day Joint Steering Committee
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Kidney disease: a global health priority Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-03
The prevalence of kidney disease and its associated morbidity and mortality continue to rise. This crisis cannot be tackled unless kidney disease is made a global public health priority.
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A new era in the science and care of kidney diseases Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-04 Carmine Zoccali, Francesca Mallamaci, Liz Lightstone, Vivek Jha, Carol Pollock, Katherine Tuttle, Peter Kotanko, Andrzej Wiecek, Hans Joachim Anders, Giuseppe Remuzzi, Kamyar Kalantar-Zadeh, Adeera Levin, Raymond Vanholder
Notable progress in basic, translational and clinical nephrology research has been made over the past five decades. Nonetheless, many challenges remain, including obstacles to the early detection of kidney disease, disparities in access to care and variability in responses to existing and emerging therapies. Innovations in drug development, research technologies, tissue engineering and regenerative
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Time for action: recognizing chronic kidney disease as a major noncommunicable disease driver of premature mortality Kidney Int. (IF 19.6) Pub Date : 2024-04-04 Germaine Wong, Amélie Bernier-Jean, Brad Rovin, Pierre Ronco, Editors of Kidney International
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Combination therapy for kidney disease in people with diabetes mellitus Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-03 Daniël H. van Raalte, Petter Bjornstad, David Z. I. Cherney, Ian H. de Boer, Paola Fioretto, Daniel Gordin, Frederik Persson, Sylvia E. Rosas, Peter Rossing, Jennifer A. Schaub, Katherine Tuttle, Sushrut S. Waikar, Hiddo J. L. Heerspink
Diabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear causes of kidney injury, occurs in approximately 20–40% of patients with diabetes mellitus. As the global prevalence of diabetes has increased, DKD has become highly prevalent and a leading cause of kidney failure, accelerated cardiovascular disease, premature mortality and global
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Chronic kidney disease and the global public health agenda: an international consensus Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-03 Anna Francis, Meera N. Harhay, Albert C. M. Ong, Sri Lekha Tummalapalli, Alberto Ortiz, Agnes B. Fogo, Danilo Fliser, Prabir Roy-Chaudhury, Monica Fontana, Masaomi Nangaku, Christoph Wanner, Charu Malik, Anne Hradsky, Dwomoa Adu, Sunita Bavanandan, Ana Cusumano, Laura Sola, Ifeoma Ulasi, Vivekanand Jha
Early detection is a key strategy to prevent kidney disease, its progression and related complications, but numerous studies show that awareness of kidney disease at the population level is low. Therefore, increasing knowledge and implementing sustainable solutions for early detection of kidney disease are public health priorities. Economic and epidemiological data underscore why kidney disease should
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The global landscape of kidney registries: immense challenges and unique opportunities Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-04-02 Christopher H. Grant, Fergus J. Caskey, M. Razeen Davids, Manisha Sahay, Aminu K. Bello, Dorothea Nitsch, Samira Bell
Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustainable and effective programs for kidney disease prevention and care. Key barriers to implementation of registries at a global scale include funding and data quality. These issues warrant the attention of the global nephrology community.
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CAR T-cell therapy—paving the way for sensitized kidney transplant patients Kidney Int. (IF 19.6) Pub Date : 2024-04-02 Tambi Jarmi, Yan Luo, Rose Mary Attieh, Yaqing Qie, Martha E. Gadd, Tanya Hundal, Shennen Mao, Hemant S. Murthy, Burcin C. Taner, Mohamed A. Kharfan-Dabaja, Hong Qin
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Sex differences in kidney metabolism and DKD Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-03-28 Ellen F. Carney
The epidemiology of diabetic kidney disease (DKD) differs by sex, with a greater risk of kidney failure in men. New data suggest that sex differences in kidney metabolism may contribute to these differing outcomes. In adults with chronic kidney disease, increased plasma levels of TCA cycle metabolites positively associated with male sex, diabetes and all-cause mortality and negatively associated with
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Single-cell lineage tracing approaches to track kidney cell development and maintenance Kidney Int. (IF 19.6) Pub Date : 2024-03-28 Baul Yoon, Hayoung Kim, Su Woong Jung, Jihwan Park
The kidney is a complex organ consisting of various cell types. Previous studies have aimed to elucidate the cellular relationships among these cell types in developing and mature kidneys using Cre-loxP–based lineage tracing. However, this methodology falls short of fully capturing the heterogeneous nature of the kidney, making it less than ideal for comprehensively tracing cellular progression during
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Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy Kidney Int. (IF 19.6) Pub Date : 2024-03-28 Shubha S. Bellur, Stéphan Troyanov, Olga Vorobyeva, Rosanna Coppo, Ian S.D. Roberts, Validation in IgA Nephropathy study group, R. Coppo MD, J. Feehaly MD, S. Troyanov MD, D.C. Cattran MD, H.T. Cook MD, I. Roberts MD, John Radcliffe, M.L. Russo PhD, V. Tesar MD, D. Maixnerova MD, S. Lundberg MD, L. Gesualdo MD, F. Emma MD, L. Fuiano MD, G. Beltrame MD, C. Rollino MD, A. Amore MD, R. Camilla MD, L.
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Clonal haematopoiesis and AKI Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-03-26 Susan J. Allison
Clonal haematopoiesis of indeterminate potential (CHIP) arises from the clonal expansion of a mutated haematopoietic stem cell. CHIP affects 10–20% of individuals aged ≥65 years and is associated with increased mortality, although only a small proportion of patients with CHIP progress to overt haematological cancer. Now, Caitlyn Vlasschaert and colleagues demonstrate that CHIP is associated with the
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Switching off SOX9 for epithelial recovery after AKI Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2024-03-26 Monica Wang
In acute kidney injury (AKI), dysregulated tissue regeneration can promote fibrosis and chronic kidney disease. Sustained SOX9 expression after AKI is a key promoter of fibrosis, according to a new study by Sanjeev Kumar and colleagues. Epigenetic analyses suggest that cells with persistent SOX9 expression have a progenitor cell-like phenotype with patterns of chromatin reorganization that are associated
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A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy Kidney Int. (IF 19.6) Pub Date : 2024-03-27 Richard Lafayette, Sean Barbour, Rubeen Israni, Xuelian Wei, Necmi Eren, Jürgen Floege, Vivekanand Jha, Sung Gyun Kim, Bart Maes, Richard K.S. Phoon, Harmeet Singh, Vladimír Tesař, Celia J.F. Lin, Jonathan Barratt
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Calibration of Priority Points for Sensitization Status of Kidney Transplant Candidates in the United States Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2024-03-21 Jesse. D. Schold, Anat R. Tambur, Sumit Mohan, Bruce Kaplan
uld improve equity in access to transplantation for disadvantaged candidates. We sought to evaluate the effect of these weights using a contemporary cohort of adult US kidney transplant candidates. Methods We used the national Scientific Registry of Transplant Recipients to evaluate factors associated with sensitization using multivariable logistic models and rates of deceased donor transplantation
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A Phase II randomized controlled trial evaluated antithrombotic treatment with fesomersen in patients with kidney failure on hemodialysis Kidney Int. (IF 19.6) Pub Date : 2024-03-26 Wolfgang C. Winkelmayer, Anthonie W.A. Lensing, Ravi I. Thadhani, Kenneth W. Mahaffey, Michael Walsh, Ákos F. Pap, Stefan Willmann, Kirstin Thelen, Sophie Hodge, Alexander Solms, Sheila J.M. Ingham, John Eikelboom, RE-THINC investigators
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Non-Lupus Full House Nephropathy Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2024-03-26 Martina Uzzo, Andreas Kronbichler, Federico Alberici, Ingeborg Bajema
n non-lupus full house nephropathy nomenclature, clinical findings and outcomes. Methods: In a reiterative process, all identified terms for non-lupus full house nephropathy and other MeSH terms were searched in PubMed. Out of 344 results, 57 records published between 1982 and 2022 were included in the analysis. Clinical data of single patients from different reports were collected. Patients were classified
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Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2024-03-26 Ruqi Xu, Qi Gao, Yuping Zhang, Yuxin Lin, Yanqin Li, Licong Su, Shiyu Zhou, Yue Cao, Peiyan Gao, Pingping Li, Fan Luo, Ruixuan Chen, Xiaodong Zhang, Sheng Nie, Xin Xu, the CRDS study Investigators
China Renal Data System (CRDS). We identified and staged AKI using patient-level serum creatinine data according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. We compared the relative risks of hospital acquired AKI among patients treated with different antivirals using Cox proportional hazards models. Results: Among 3273 patients, 1480 (45%), 681 (21%), 489 (15%) and 623 (19%) were
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Transcription factor Nrf2 activation regulates NETosis, endothelial injury, and kidney disease in myeloperoxidase-positive antineutrophil cytoplasmic antibody-associated vasculitis Kidney Int. (IF 19.6) Pub Date : 2024-03-25 Yusho Ueda, Daigo Nakazawa, Saori Nishio, Satoka Shiratori-Aso, Takashi Kudo, Atsuko Miyoshi-Harashima, Kanako Watanabe-Kusunoki, Fumihiko Hattanda, Sari Iwasaki, Takahiro Tsuji, Utano Tomaru, Yasuaki Aratani, Mamiko Yamamoto, Akihiro Ishizu, Tatsuya Atsumi
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Anti-Neuron–Derived Neurotrophic Factor Antibodies in Secondary Membranous Nephropathy Caused by Syphilis: A Case Report Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-03-22 Daisuke Honda, Issei Okunaga, Daichi Omote, Hiroko Inoue, Kaho Yamasaki, Hanae Wakabayashi, Michiko Suzuki, Masashi Aizawa, Shigeki Tomita, Jun-ichiro Ikeda, Katsuhiko Asanuma
We present the case of a 61-year-old man who developed nephrotic syndrome as a result of syphilis-associated secondary membranous nephropathy (MN). The patient showed nephrotic syndrome remission following antibiotic treatment for syphilis alone. Pathologically, the target antigen of immune complexes accumulated on glomerular basement membranes (GBM) in secondary MN caused by syphilis has been reported
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Hypermethylation leads to the loss of HOXA5, resulting in JAG1 expression and NOTCH signaling contributing to kidney fibrosis Kidney Int. (IF 19.6) Pub Date : 2024-03-21 Xiao Xiao, Wei Wang, Chunyuan Guo, Jiazhu Wu, Sheng Zhang, Huidong Shi, Sangho Kwon, Jiankang Chen, Zheng Dong
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Genetic testing in kidney transplantation helped develop a morbidity gene panel for evaluation of kidney transplant recipients Kidney Int. (IF 19.6) Pub Date : 2024-03-21 Becky M. Ma, Naama Elefant, Martina Tedesco, Kelsie Bogyo, Natalie Vena, Sarath K. Murthy, Shiraz A. Bheda, Sandy Yang, Nikita Tomar, Jun Y. Zhang, Syed Ali Husain, Sumit Mohan, Krzysztof Kiryluk, Hila Milo Rasouly, Ali G. Gharavi
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Biomarker use in acute kidney injury: are we there yet? Kidney Int. (IF 19.6) Pub Date : 2024-03-20 T. Alp Ikizler
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Throwing off the keratin chains: a potential therapy for hereditary podocytopathy Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Kálmán Tory
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A toolkit for ISN’s registry initiative, SharE-RR Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Maria Pippias, Rajitha A. Abeysekera, Silvia Arruebo, M. Razeen Davids, Sandrine Damster, Maria C. Gonzales-Bedat, Norio Hanafusa, Junichi Hoshino, Anne Hradsky, Georgina L. Irish, Kitty J. Jager, Sabine Karam, Vivek Kumar, Stephen P. McDonald, Guillermo J. Rosa-Diez, Elliot K. Tannor, James B. Wetmore, Fergus J. Caskey
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Autosomal dominant chronic tubulointerstitial nephropathy: do not forget amyloidosis Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Frank Bridoux, Samih H. Nasr
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Charting new frontiers in IgA nephropathy: a paradigm shift toward precision medicine and early intervention? Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Haresh Selvaskandan, Jonathan Barratt
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Oligonephronia: another piece in the CKDu jigsaw? Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Wendy E. Hoy, John F. Bertram
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Integrating essence of “time” for blood pressure control in nephrology care Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Yejin Mok, Kunihiro Matsushita
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Are biomarkers in acute kidney injury ready for prime time? The time is right for a second look Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Chirag R. Parikh, Steven G. Coca
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Interleukin-37: a new therapeutic target in autosomal dominant polycystic kidney disease Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Bo Yang, Steven D. Crowley
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Biomarker blues: balancing hope and hype in acute kidney injury Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Sushrut S. Waikar
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Back to the future: the uncharted role of T cells in chronic and unexplained microvascular inflammation Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Jasper Callemeyn, Maarten Naesens
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Cytoreductive treatment and kidney vascular damage in patients with chronic myeloproliferative neoplasms Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Ivan Krecak, Marko Lucijanic
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Thibaut d’Izarny-Gargas, Alexandre Karras, Jean-Paul Duong-Van-Huyen
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Lysosomal cystine accumulation activates mTOR signaling in cystinosis: are mTOR inhibitors the cure? Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Salómon Christer, Matias Simons
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Multimodal characterization of sexual dimorphism in the mammalian kidney Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Haikuo Li, Benjamin D. Humphreys
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Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: known knowns and known unknowns Kidney Int. (IF 19.6) Pub Date : 2024-03-20 Adeera Levin, Sofia B. Ahmed, Juan Jesus Carrero, Bethany Foster, Anna Francis, Rasheeda K. Hall, Will G. Herrington, Guy Hill, Lesley A. Inker, Rümeyza Kazancıoğlu, Edmund Lamb, Peter Lin, Magdalena Madero, Natasha McIntyre, Kelly Morrow, Glenda Roberts, Dharshana Sabanayagam, Elke Schaeffner, Michael Shlipak, Rukshana Shroff, Navdeep Tangri, Teerawat Thanachayanont, Ifeoma Ulasi, Germaine Wong, Chih-Wei
The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD) updates the KDIGO 2012 guideline and has been developed with patient partners, clinicians, and researchers around the world, using robust methodology. This update, based on a substantially broader base of evidence than has previously been available, reflects