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The immune response to pig-to-human kidney xenografts Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2023-09-27 Ellen F. Carney
A recent study has characterized the early immune response to xenotransplantation. The researchers used a multimodal approach to phenotype two α-1,3-galactosyltransferase-knockout pig kidney xenografts that were transplanted into brain-dead human recipients. The xenografts remained functional and produced urine throughout the 54-h study period, with no evidence of hyperacute rejection.
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Acute kidney injury in patients with burns Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2023-09-27 Matthieu Legrand, Audra T. Clark, Javier A. Neyra, Marlies Ostermann
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Biomolecular condensates in kidney physiology and disease Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2023-09-26 Guoming Gao, Emily S. Sumrall, Sethuramasundaram Pitchiaya, Markus Bitzer, Simon Alberti, Nils G. Walter
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Should I Take a Transplant Kidney from a Person with COVID Infection? Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2023-09-22 Faizan Awan
An abstract is unavailable.
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The spectrum of glomerular and vascular kidney pathology associated with myeloproliferative neoplasms. Kidney Int. (IF 19.6) Pub Date : 2023-09-26 Thibaut d’Izarny-Gargas, Pierre Isnard, Idris Boudhabhay, David Buob, Anissa Moktefi, Charel Linster, Aurélie Hummel, Emmanuel Esteve, Vincent Audard, Hélène Lazareth, Nadine Maroun, Alexandre Hertig, Clément Gosset, Charlotte Jouzel, Sarah Permal, Camille Domenger, Olivier Kosmider, Marion Rabant, Alexandre Karras, Jean-Paul Duong-Van-Huyen
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Gene therapy in a model of nephrotic syndrome Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2023-09-25 Susan J. Allison
Mutations in NPHS2 — which encodes the slit diaphragm protein, podocin — are the most common genetic cause of steroid-resistant nephrotic syndrome. Using genetic models of nephrotic syndrome, Ding et al. now demonstrate that adeno-associated virus (AAV)-mediated delivery of podocin can rescue defects in NPHS2.
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The role of complement in kidney disease Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2023-09-21 Vojtech Petr, Joshua M. Thurman
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The conclusion that myeloperoxidase inhibition is not protective against anti-neutrophil cytoplasmic autoantibody–associated vasculitis is premature Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Tomoki Taniguchi, Ryosuke Hiwa, Akio Morinobu
Abstract not available
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The Treatment of Primary IgA Nephropathy: Change, Change, Change Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-23 Dawn J. Caster, Richard A. Lafayette
IgA nephropathy (IgAN) is the most common glomerular disease in the world. However, the approach to treatment remains controversial. There has been an explosion of clinical trials over the past decade both further examining corticosteroid use and ushering in additional treatment considerations, including two newly approved therapies for IgAN. Sodium glucose cotransporter-2 inhibitors are proving to
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Kidney Transplantation in Patients With AA Amyloidosis: Outcomes in a French Multicenter Cohort Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-22 Chloë Schwarz, Sophie Georgin-Lavialle, Yannis Lombardi, Olivier Marion, Frédéric Jambon, Christophe Legendre, David Marx, Charlène Levi, Fatouma Toure, Moglie Le Quintrec, Mickael Bobot, Marie Matignon, Amaury Dujardin, Mehdi Maanaoui, Sébastien Cuozzo, Arwa Jalal-Eddine, Kévin Louis, Inna Mohamadou, François Brazier, Tristan De Nattes, Yosu Luque
Rationale & Objective Outcomes of kidney transplantation for patients with renal AA amyloidosis are uncertain, with reports of poor survival and high rates of disease recurrence. However, data are inconclusive and mostly based on studies from the early 2000s and earlier. Study Design Retrospective multicenter cohort study. Setting & Participants We searched the French national transplant database to
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Apathy Symptoms, Physical and Cognitive Function, Health-Related Quality of Life, and Mortality in Older Patients With CKD: A Longitudinal Observational Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-22 Carlijn GN. Voorend, Marjolijn van Buren, Noeleen C. Berkhout-Byrne, Angèle PM. Kerckhoffs, Mathijs van Oevelen, Jacobijn Gussekloo, Edo Richard, Willem Jan W Bos, Simon P. Mooijaart
Rationale & Objective Apathy reflects diminished motivation, goal-directed behavior, and emotions, as well as less engagement in social interactions. Apathy overlaps with depression and is associated with cognitive decline. In the older individuals with chronic kidney disease (CKD), both depression and cognitive impairments are common, but apathy symptoms have been underreported. We investigated the
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OpenAI’s ChatGPT and Its Potential Impact on Narrative and Scientific Writing in Nephrology Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-22 John T. Daugirdas
Abstract not available
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Brain Natriuretic Peptide Monitoring in CKD: Ready for Prime Time? Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-21 Alexander J. Kula, Nisha Bansal
Abstract not available
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Intussusception as a complication of idiopathic nephrotic syndrome Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Fanny Dreant, Benedicte Sautenet, Christelle Barbet, Jean-Michel Halimi
Abstract not available
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Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-21 Mary Hannan, Jinsong Chen, Jesse Hsu, Xiaoming Zhang, Milda R. Saunders, Julia Brown, Mara McAdams-DeMarco, Madhumita Jena Mohanty, Rahul Vyas, Zahraa Hajjiri, Eunice Carmona-Powell, Natalie Meza, Anna C. Porter, Ana C. Ricardo, James P. Lash
Rationale & Objective Frailty is common in individuals with chronic kidney disease (CKD) and increases the risk of adverse outcomes in adults with kidney failure requiring dialysis. However, this relationship has not been thoroughly evaluated among those with non-dialysis dependent CKD. Study Design Prospective cohort study. Setting & Participants: 2,539 adults in the Chronic Renal Insufficiency Cohort
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The Association of Class I and II Human Leukocyte Antigen Serotypes With End-Stage Kidney Disease Due to Membranoproliferative Glomerulonephritis and Dense Deposit Disease Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Halimat Afolabi, Bing M. Zhang, Michelle O’Shaughnessy, Glenn M. Chertow, Richard Lafayette, Vivek Charu
Rationale & Objective Membranoproliferative glomerulonephritis (MPGN), encompassing several distinct diseases, is a rare but significant cause of kidney failure in the US. Potential etiologies of MPGN are unclear, but prior studies have suggested dysregulation of the alternative complement pathway, and recently, autoimmunity as potential mechanisms driving MPGN pathogenesis. In this study, we examined
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Processes of Care After Hospital Discharge for Survivors of Acute Kidney Injury: A Population-Based Cohort Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-19 Sandeep Brar, Feng Ye, Matthew T. James, Tyrone G. Harrison, Neesh Pannu
Rationale & Objective Survivors of acute kidney injury (AKI) are at high risk of adverse outcomes. Monitoring of kidney function, screening for proteinuria, use of statins and renin-angiotensin-aldosterone system inhibitors (RAASi), and nephrology follow-up among survivors have not been fully characterized. We sought to examine these processes of care after discharge in survivors of hospitalized AKI
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Outcomes of Hospital-Acquired Hypernatremia Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2023-09-18 Soraya Arzhan, Maria-Eleni Roumelioti, Igor Litvinovich, Cristian G. Bologa, Mark L Unruh
y disease. Methods We conducted an observational retrospective cohort study, and we analyzed the data of 1,728,141 million patients extracted from the Cerner Health Facts database (January 1st 2000- June 30th 2018). In this report we investigated the association between hospital-acquired hypernatremia (serum sodium (Na) levels>145 mEq/L) and in-hospital mortality or discharge dispositions with kidney
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Nurse Practitioner Care Compared to Primary Care or Nephrologist Care in Early CKD Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2023-09-18 James, Matthew T., Scory, Tayler D., Novak, Ellen, Manns, Braden J., Hemmelgarn, Brenda R., Bello, Aminu K., Ravani, Pietro, Kahlon, Bhavneet, MacRae, Jennifer M., Ronksley, Paul E.
Background: Early interventions in chronic kidney disease (CKD) have been shown to improve health outcomes; however, gaps in access to nephrology care remain common. Nurse practitioners can improve access to care; however, the quality and outcomes of nurse practitioner care for CKD are uncertain. Methods: In this propensity score matched cohort study, patients with CKD meeting criteria for nurse practitioner
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Use of kidneys from SARS-CoV-2 infected donors Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2023-09-21 Monica Wang
Transplantation of kidneys from donors with detectable SARS-CoV-2 RNA is generally deemed safe. In a new study, Miklos Molnar and colleagues investigated whether transplanting organs from deceased infected donors, including those who died from COVID-19, can affect transplant outcomes.
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Using causal directed acyclic graphs (DAGs) to select patient-important outcomes in transplantation trials—interventions to treat polyomavirus infection as an example Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Yue Wu, Michael Dymock, Ryan Gately, Julie A. Marsh, Carmel Hawley, Germaine Wong, Thomas L. Snelling
Abstract not available
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Linking donor-specific antibody generation with natural killer cells in antibody-mediated kidney graft rejection Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Griffith B. Perkins, Robert L. Fairchild
Natural killer (NK) cell infiltration of kidney allografts is a distinguishing feature of antibody-mediated rejection. Bailly et al. identify a distinct population of cytotoxic CD160+ interleukin-21 receptor+ CD56dimCD16bright NK cells that are uniquely found in the peripheral blood of donor-specific antibody–positive kidney transplant recipients and are present in kidney allografts with active antibody-mediated
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Suppressing succinate accumulation during ischemia protects the kidney from IRI Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Nobuaki Nishima, Shinji Tanaka
Previous studies have indicated that succinate accumulation during kidney ischemia, and its oxidation during reperfusion, results in the production of excessive reactive oxygen species, mitochondrial dysfunction, and kidney injury. In this issue, Oh et al. have reported that pyruvate dehydrogenase kinase 4 (PDK4) inhibition in proximal tubules ameliorates kidney ischemia/reperfusion injury via suppressed
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Autoregulatory mission impossible: when afferent arterioles lose contractility Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Jing Wu, Thu H. Le
The myogenic response of afferent arterioles is a key autoregulatory mechanism that protects the glomeruli from barotrauma. Afferent arteriolar smooth muscle cells contract to increased intraluminal pressure through mechanosensitive cation channels and interactions between integrin and extracellular matrix that trigger calcium-dependent actomyosin contraction. The study by Feng et al. provides evidence
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A first small step toward personalized immunosuppression Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Klemens Budde, Lionel Rostaing
Lloberas et al. provide further evidence for the benefits of an individualized tacrolimus dosing algorithm based on population pharmacokinetics and pharmacogenetics. Better tacrolimus dosing could prevent underexposure and overexposure and potentially save costs. Most important, this could be the start of precision medicine in kidney transplantation, incorporating improved immunologic and donor quality
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Fernanda Florez-Barros, Siobhan Bearder, Bengt Kull, Adrian Freeman, Attila Mócsai, Michael G. Robson
Abstract not available
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Prioritizing water stewardship in kidney replacement therapies Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Caroline E. Stigant, Katherine A. Barraclough, Mark Harber, Nigel S. Kanagasundaram, David S. Goldfarb, Charu Malik, Vivekanand Jha, Raymond C. Vanholder
Abstract not available
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The authors reply Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Mohamed Ben Hmida, Tahar Mechichi, Giorgina Barbara Piccoli, Mohamed Ksibi
Abstract not available
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Corrigendum to “International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology.” Kidney International, 2023;104:36–45 Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Masaomi Nangaku, A. Richard Kitching, Peter Boor, Alessia Fornoni, Jürgen Floege, P. Toby Coates, Jonathan Himmelfarb, Rachel Lennon, Hans-Joachim Anders, Benjamin D. Humphreys, Fergus J. Caskey, Agnes B. Fogo
Abstract not available
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Cryofibrinogen-associated membranoproliferative glomerulonephritis Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Minah Kim, Sung Sun Kim, Hoon-In Choi, Hong Sang Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim, Chang Seong Kim
Abstract not available
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The Case | Acute kidney injury following infective endocarditis Kidney Int. (IF 19.6) Pub Date : 2023-09-20 Cyril Mousseaux, Ellie Tang, Maxime Tristant, Yosu Luque, Vincent Frochot, Laurent Mesnard, Dominique Bazin, Cédric Rafat, David Buob, Emmanuel Letavernier
Abstract not available
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A Case of Autosomal Dominant Polycystic Kidney Disease With Resolution of Massive Pericardial Effusion After Renal Transcatheter Artery Embolization Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Kumi Nitta, Yuki Oba, Daisuke Ikuma, Hiroki Mizuno, Akinari Sekine, Eiko Hasegawa, Masayuki Yamanouchi, Tatsuya Suwabe, Masahide Tokue, Masanori Shiba, Naoki Sawa, Yoshifumi Ubara
A 68-year-old woman with autosomal dominant polycystic kidney disease (ADPKD) on hemodialysis was admitted for progressive dyspnea over 6 months. On chest X-ray, her cardiothoracic ratio (CTR) had increased from 52.2% 6 months prior, to 71%, and echocardiography revealed diffuse pericardial effusion and right ventricular diastolic insufficiency. A resultant pericardial tamponade was thought to be the
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Etiologic and Diagnostic Implications of Morbidity and Mortality Associations When Cystatin C–Based Estimated GFR Is Lower Than Creatinine-Based Estimated GFR Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Anders O. Grubb, Martin Magnusson, Anders Christensson
Abstract not available
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Advance Care Planning and Palliative Care Consultation in Kidney Transplantation Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Marlena C. Fisher, Xiaomeng Chen, Deidra C. Crews, Lyndsay DeGroot, Nwamaka D. Eneanya, Nidhi Ghildayal, Marshall Gold, Yi Liu, Justin J. Sanders, Jennifer S. Scherer, Dorry L. Segev, Mara A. McAdams-DeMarco
Rationale & Objective Due to the high risk of waitlist mortality and post-transplant complications, kidney transplant (KT) patients may benefit from advance care planning (ACP) and palliative care consultation (PCC). We quantified the prevalence and racial disparities in ACP and PCC among KT candidates and recipients. Study Design Prospective cohort study Setting & Participants 2,575 adult KT candidates
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Cryoglobulinemic Vasculitis in Disguise: Cryofibrinogenemia as Variant of Monoclonal Gammopathy of Renal Significance Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-19 Christina M. Gant, Carin A. Koelman, Tri Q. Nguyen TQ, Alferso C. Abrahams, Jack F.M. Wetzels, Caroline Duineveld, Margot Jak, Monique C. Minnema, Saskia K. Klein, Joannes F.M. Jacobs, Renate J. Bosma
Monoclonocal gammopathy with cryoactivity (i.e. cryoglobulins) that causes glomerulonephritis is considered within the spectrum of monoclonal gammopathy of renal significance (MGRS). Cryofibrinogenemia (cryoactivity of coagulation factors) is very rarely associated with glomerulonephritis. We present a 39 year old woman with a relapsing nephrotic syndrome. Laboratory investigation detected cryofibrinogen
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Experiences of Indigenous Patients Receiving Dialysis: Systematic Review of Qualitative Studies Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-18 Marianne Kerr, Allison Jaure, Jacqueline H. Stephens, Siah Kim, Richard Cutler, Brydee Cashmore, Michelle Dickson, Nicole Evangelidis, Jaquelyne T. Hughes, Ieyesha Roberts, Nicole Scholes-Robertson, Victoria Sinka, GradDip, Jonathan C. Craig
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A Young Man With Chronic Refractory Hypokalemia: A Quiz Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Mohamad Hanouneh, Carmen Elena Cervantes
Abstract not available
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The Significance of Hematuria in Podocytopathies Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2023-09-21 Dorota Marchel, Howard Trachtman, Maria Larkina, Margaret Helmuth, Jennifer Y. Lai Yee, Damian Fermin, Andrew S. Bomback, Pietro A. Canetta, Debbie S. Gipson, Amy K. Mottl, Rulan S. Parekh, Manish K. Saha, Matthew G. Sampson, Richard A. Lafayette, Laura H. Mariani, Nephrotic Syndrome Study Network (NEPTUNE), Cure Glomerulonephropathy (CureGN), Nephrotic Syndrome Study Network (NEPTUNE), Cure Glomerulonephropathy
Hematuria was assessed at the initial urinalysis in participants with the following podocytopathies, membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis, in the Nephrotic Syndrome Study Network (NEPTUNE) and Cure Glomerulonephropathy (CureGN) cohorts with >24 months of follow-up. Multivariable Cox proportional hazards models were fit for time to composite outcome
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Polycystic Kidney Disease Diet: What Is Known and What Is Safe Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2023-09-20 Fouad T. Chebib, Kristen L. Nowak, Michel B. Chonchol, Kristen Bing, Ahmad Ghanem, Frederic F. Rahbari-Oskoui, Neera K. Dahl, Michal Mrug
induce metabolic reprogramming and slow ADPKD progression. We review the available evidence supporting the efficacy and safety of these interventions in ADPKD. Dietary interventions show promise in managing ADPKD by improving metabolic health and reducing oxidative stress. However, while preclinical studies have shown favorable outcomes, limited clinical evidence supports their effectiveness. Also
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Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2023-09-20 Gonzalez Sepulveda, Juan M., Mehrotra, Sanjay, Yang, Jui-Chen, Schantz, Karolina J., Becker, Yolanda, Formica, Richard, Ladner, Daniela P., Kaufman, Dixon, Friedewald, John
Background In the US, over 50% of kidneys in the lowest 15% quality range (those with kidney donor profile index>85) are discarded. Studies suggest that utilizing more of these kidneys could benefit patients waiting for a transplant. This study assesses the tradeoffs physicians make when selecting recipients for lower quality kidneys. Methods A discrete-choice experiment (DCE) was administered to surgeons
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Performance of GFR Estimating Equations in Young Adults Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Lesley A. Inker, Hocine Tighiouart, Ogechi M. Adingwupu, Derek K. Ng, Michelle M. Estrella, David Maahs, Wei Yang, Marc Froissart, Michael Mauer, Roberto Kalil, Vicente Torres, Martin de Borst, Goran Klintmalm, Emilio D. Poggio, Jesse C. Seegmiller, Peter Rossing, Susan L. Furth, Bradley A. Warady, George J. Schwartz, Ruben Velez, Andrew Levey
Abstract not available
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Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical Trials Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Elizabeth A. Kiernan, David Hu, Heather Thiessen Philbrook, Joachim H. Ix, Joseph V. Bonventre, Steven G. Coca, Dennis G. Moledina, Linda F. Fried, Michael G. Shlipak, Chirag R. Parikh
Rationale & Objective Urinary biomarkers of injury, inflammation and repair may help phenotype observed AKI in clinical trials. We evaluated differences in biomarkers between those randomized to monotherapy or to combination RAAS blockade in VA NEPHRON-D, acknowledging an increased proportion of observed AKI in the combination arm. Study Design Longitudinal analysis. Setting & Participants: A sub-study
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Kidney Transplant Clinicians’ Perceptions of Palliative Care for Patients With Failing Allografts in the US: A Mixed Methods Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Naoka Murakami, Amanda J. Reich, Katherine He, Samantha L. Gelfand, Richard E. Leiter, Kate Sciacca, Joel T. Adler, Emily Lu, Song C. Ong, Beatrice P. Concepcion, Neeraj Singh, Haris Murad, Prince Anand, Sarah J. Ramer, Darshana Dadhania, Krista L. Lentine, Joshua R. Lakin, Tarek Alhamad
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Factors Associated With Non-Vaccination for Influenza Among Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Junichi Ishigami, Bernard G. Jaar, Jeanne B. Charleston, James P. Lash, Julia Brown, Jing Chen, Katherine T. Mills, Jonathan Taliercio, Sheru Kansal, Deidra C. Crews, Kristin A. Riekert, David W. Dowdy, Lawrence J. Appel, Kunihiro Matsushita
Rationale & Objective Vaccination for influenza is strongly recommended for people with chronic kidney disease (CKD) due to their immunocompromised state. Identifying risk factors for not receiving an influenza vaccine (“non-vaccination”) could inform strategies for improving vaccine uptake in this high-risk population. Study Design Longitudinal observational study. Setting & Participants: 3,692 Chronic
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The Status of Kidney Transplant Fellowship in the United States: A Survey of Program Directors Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Shilpi Shah, Vishnu S. Potluri, Roy D. Bloom, Mary Ann Lim
Abstract not available
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Vitamin D in CKD: An Unfinished Story Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-16 Simon Hsu, Marc G. Vervloet, Ian H. de Boer
Abstract not available
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Genetic Markers Among the Israeli Druze Minority Population With End-Stage Kidney Disease Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-15 Omer Shlomovitz, Danit Atias-Varon, Dina Yagel, Ortal Barel, Hadas Shasha-Lavsky, Karl Skorecki, Aviva Eliyahu, Younes Bathish, Victor Frajewicki, Daniel Kushnir, Rinat Zaid, Tamar Paperna, Ayala Ofir, Marina Tchirkov, Kamal Hassan, Etty Kruzel, Khaled Khazim, Ronit Geron, Irit Weisman, Anaam Hanut, Asaf Vivante
Rationale & Objective Genetic etiologies have been identified among approximately 10% of adults with chronic kidney disease. However, data are lacking regarding the prevalence of monogenic etiologies especially among members of minority groups. The objective of this study was to characterize the genetic markers among members of an Israeli minority group with end-stage kidney disease (ESKD). Study Design
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Building Towards Clinical Translation: New Study Refines Genetic Architecture of IgA Nephropathy Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-15 Andrew O. Kearney, Edgar Lerma, Jennie Lin
Abstract not available
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Efficacy and Safety of Upacicalcet in Hemodialysis Patients with Secondary Hyperparathyroidism: A Randomized Placebo-Controlled Trial Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2023-09-11 Takashi Shigematsu, Fumihiko Koiwa, Yoshitaka Isaka, Masafumi Fukagawa, Keiko Hagita, Yukihisa S. Watanabe, Daisuke Honda, Tadao Akizawa
ts with secondary hyperparathyroidism receiving HD. Methods In this phase 3, double-blind, placebo-controlled study, we randomized Japanese patients undergoing HD with serum intact PTH (iPTH) concentrations >240 pg/ml and corrected calcium concentrations ≥8.4 mg/dl. Either upacicalcet or placebo was administered after each HD session for 24 weeks. The primary outcome was the percentage of participants
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How I Manage Anticoagulation of Kidney Replacement Therapy in Patients with Acute-on-Chronic Liver Failure Clin. J. Am. Soc. Nephrol. (IF 9.8) Pub Date : 2023-09-12 Thomas Demuyck, Alexander Wilmer, Bjorn Meijers
An abstract is unavailable. This article is available as a PDF only.
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Lymph vessels, Na+ and the teleological science of hypertension Nat. Rev. Nephrol. (IF 41.5) Pub Date : 2023-09-15 Jens M. Titze
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Secrets and myths between tubules – new insights on erythropoietin production from single cell technology Kidney Int. (IF 19.6) Pub Date : 2023-09-14 Kai-Uwe Eckardt, Armin Kurtz
Abstract not available
更新日期：2023-09-27
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