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Orthodontic retention: Rationale and periodontal implications Periodontol. 2000 (IF 18.6) Pub Date : 2024-03-18 Padhraig S. Fleming, Nikolaos Pandis
Post-treatment change in the form of true relapse and physiological and maturational effects is common following orthodontics. The unpredictable nature of these manifestations dictates a conservative, near-universal approach to retention. Both fixed and removable forms of retention are popular with the latter constrained by variable levels of adherence particularly in the medium- to long-term. Fixed
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Differences between first‐ and second‐generation autologous platelet concentrates Periodontol. 2000 (IF 18.6) Pub Date : 2024-03-15 Elena Calciolari, Marina Dourou, Aliye Akcali, Nikolaos Donos
AbstractAutologous platelet concentrates (APCs) applied alone or combined with other biomaterials are popular bioactive factors employed in regenerative medicine. The main biological rationale of using such products is to concentrate blood‐derived growth factors and cells into the wound microenvironment to enhance the body's natural healing capacity. First‐generation APC is represented by platelet‐rich
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The role of viruses in oral mucosal lesions Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-27 Henrik Dommisch, Andrea Maria Schmidt‐Westhausen
The mucosa of the oral cavity is exposed to a large number of different microorganisms such as archaea, bacteria, fungi, parasites, and viruses. Among those, viruses cause specific infections, which can easily be transmitted from one person to another. The infectious route may not only include patients and their relatives but also the dental professional team. Thus, a wide knowledge regarding specific
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Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-27 Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw
Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent clinical studies are described that evaluate how the treatment
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APCs in sinus floor augmentation Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-16 Pascal Valentini, Elena Calciolari, Sebastien Monlezun, Aliye Akcalı, Nikos Donos, Marc Quirynen
After tooth loss in the posterior area of the maxilla, sinus floor elevation is often required to compensate the vertical bone loss due to sinus pneumatization. This narrative review reports on the potential benefits of autologous platelet concentrates (APCs) during this procedure. As for transcrestal approach, APCs have been used as “sole” substitute/graft. However, because of the low number of clinical
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The role of programmed death receptor (PD-)1/PD-ligand (L)1 in periodontitis and cancer Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-13 Sabine Groeger, Joerg Meyle
The programmed-death-ligand-1 (PD-L1) is an immune-modulating molecule that is constitutively expressed on various immune cells, different epithelial cells and a multitude of cancer cells. It is a costimulatory molecule that may impair T-cell mediated immune response. Ligation to the programmed-death-receptor (PD)-1, on activated T-cells and further triggering of the related signaling pathways can
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The development of non-resorbable bone allografts: Biological background and clinical perspectives Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-07 Richard J. Miron, Masako Fujioka-Kobayashi, Michael A. Pikos, Toshiaki Nakamura, Takatomo Imafuji, Yufeng Zhang, Yukiya Shinohara, Anton Sculean, Yoshinori Shirakata
Bone grafts are typically categorized into four categories: autografts, allografts, xenografts, and synthetic alloplasts. While it was originally thought that all bone grafts should be slowly resorbed and replaced with native bone over time, accumulating evidence has in fact suggested that the use of nonresorbable xenografts is favored for certain clinical indications. Thus, many clinicians take advantage
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Etiology, pathogenesis and treatment of peri-implantitis: A European perspective Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-02 Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks
Peri-implantitis is a plaque-associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri-implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri-implantitis has become a major disease burden in dentistry. An understanding of the diagnosis, etiology and pathogenesis, epidemiology, and treatment of peri-implantitis
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The role of the epithelial sentinels, Langerhans cells and γδT cells, in oral squamous cell carcinoma Periodontol. 2000 (IF 18.6) Pub Date : 2024-01-25 Avi-Hai Hovav, Asaf Wilensky
Oral squamous cell carcinoma (OSCC) arises in the oral epithelium, a tissue in which immune surveillance is mediated by its primary resident leukocytes, Langerhans cells (LCs), and γδT cells. Under steady-state conditions, LCs and γδT cells play a critical role in maintaining oral mucosal homeostasis. As antigen-presenting cells of stratified epithelia, LCs respond to various challenges faced by the
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Role of innate host defense proteins in oral cancerogenesis Periodontol. 2000 (IF 18.6) Pub Date : 2024-01-24 Jochen Winter, Søren Jepsen
It is nowadays well accepted that chronic inflammation plays a pivotal role in tumor initiation and progression. Under this aspect, the oral cavity is predestined to examine this connection because periodontitis is a highly prevalent chronic inflammatory disease and oral squamous cell carcinomas are the most common oral malignant lesions. In this review, we describe how particular molecules of the
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Biological processes and factors involved in soft and hard tissue healing Periodontol. 2000 (IF 18.6) Pub Date : 2024-01-20 Mark Bartold, Saso Ivanovski
Wound healing is a complex and iterative process involving myriad cellular and biologic processes that are highly regulated to allow satisfactory repair and regeneration of damaged tissues. This review is intended to be an introductory chapter in a volume focusing on the use of platelet concentrates for tissue regeneration. In order to fully appreciate the clinical utility of these preparations, a
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Disparities and social determinants of periodontal diseases Periodontol. 2000 (IF 18.6) Pub Date : 2024-01-13 Jasim M. Albandar
Periodontal diseases are highly prevalent in populations worldwide and are a major global public health problem, with major negative impacts on individuals and communities. This study investigates evidence of disparities in periodontal diseases by age groups, gender, and socioeconomic factors. There is ample evidence that these diseases disproportionally affect poorer and marginalized groups and are
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Guided bone regeneration in implant dentistry: Basic principle, progress over 35 years, and recent research activities Periodontol. 2000 (IF 18.6) Pub Date : 2024-01-09 Daniel Buser, Istvan Urban, Alberto Monje, Marcel F. Kunrath, Christer Dahlin
Bone augmentation procedures are frequent today in implant patients, since an implant should be circumferentially anchored in bone at completion of bone healing to have a good long-term stability. The best documented surgical technique to achieve this goal is guided bone regeneration (GBR) utilizing barrier membranes in combination with bone fillers. This clinical review paper reflects 35 years of
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Fresh-frozen allogeneic bone blocks grafts for alveolar ridge augmentation: Biological and clinical aspects Periodontol. 2000 (IF 18.6) Pub Date : 2024-01-09 Andreas Stavropoulos, Camila Chierici Marcantonio, Vithor Xavier Resende de Oliveira, Élcio Marcantonio, Guilherme José Pimentel Lopes de Oliveira
The possibilities for oral bone regeneration procedures vary depending on the type of bone defect to be treated, which in turn dictate the type of graft to be used. Atrophic alveolar ridges are non-contained defects and pose a challenging defect morphology for bone regeneration/augmentation. Successful results are regularly obtained with the use of particulate grafts in combination with barrier membranes
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Mechanical plaque removal in step-1 of care Periodontol. 2000 (IF 18.6) Pub Date : 2023-12-26 G. A. (Fridus) Van der Weijden, Cor van Loveren
Maintaining a regular oral hygiene routine is essential for taking care of our mouths, ensuring healthy teeth, and achieving fresh breath. Patient education on oral hygiene is an important component of their overall treatment. Firstly, patients should be informed about the direct connection between bacteria in dental plaque and oral diseases. It is important for patients to understand that these conditions
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Periodontitis and risk of cancer: Mechanistic evidence Periodontol. 2000 (IF 18.6) Pub Date : 2023-12-15 Giacomo Baima, Margherita Minoli, Dominique S. Michaud, Mario Aimetti, Mariano Sanz, Bruno G. Loos, Mario Romandini
This review aims to critically analyze the pathways of interaction and the pathogenic mechanisms linking periodontitis and oral bacteria with the initiation/progression of cancer at different body compartments. A higher risk of head and neck cancer has been consistently associated with periodontitis. This relationship has been explained by the local promotion of dysbiosis, chronic inflammation, immune
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Biological biomarkers of oral cancer Periodontol. 2000 (IF 18.6) Pub Date : 2023-12-10 Allan Radaic, Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo-Chin Hung, Fereshteh Najarzadegan, David T. Wong, Hung Ton-That, Cun-Yu Wang, Yvonne L. Kapila
The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based on histopathological grading of oral dysplasia, it is estimated that severe dysplasia has a malignant transformation rate of 7%–50%. Despite these numbers, oral dysplasia
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Ten years of injectable platelet-rich fibrin Periodontol. 2000 (IF 18.6) Pub Date : 2023-11-30 Richard J. Miron, Reinhard Gruber, Nima Farshidfar, Anton Sculean, Yufeng Zhang
The use of platelet-rich fibrin (PRF) has seen widespread advantages over platelet-rich plasma (PRP) in many fields of medicine. However, until 2014, PRF remained clinically available only in its solid clotted form. Modifications to centrifugation protocols and tube technology have led to the development of a liquid injectable version of PRF (i-PRF). This narrative review takes a look back at the technological
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Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal Periodontol. 2000 (IF 18.6) Pub Date : 2023-11-23 Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard
In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)). Cardiovascular diseases are a group
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Extended platelet-rich fibrin Periodontol. 2000 (IF 18.6) Pub Date : 2023-11-20 Richard J. Miron, Michael A. Pikos, Nathan E. Estrin, Masako Kobayashi-Fujioka, Alan Rene Espinoza, Hussein Basma, Yufeng Zhang
Platelet-rich fibrin (PRF) has been characterized as a regenerative biomaterial that is fully resorbed within a typical 2–3 week period. Very recently, however, a novel heating process was shown to extend the working properties of PRP/PRF from a standard 2–3 week period toward a duration of 4–6 months. Numerous clinicians have now utilized this extended-PRF (e-PRF) membrane as a substitute for collagen
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Indications and surgical technique for distraction osteogenesis of the alveolar bone for augmentation prior to insertion of dental implants Periodontol. 2000 (IF 18.6) Pub Date : 2023-11-08 Hans-Joachim Nickenig, Joachim E. Zöller, Matthias Kreppel
When bone is limited, short, ultra-short, or narrow implants help to restore oral rehabilitation with an acceptable long-term outcome. This becomes more difficult with severe vertical bone loss. Guided bone regeneration, onlay block transplantation, or sandwich osteotomy have been established to build up these defects. The alternative to the alveolar distraction osteogenesis (ADO) has only been established
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Emerging factors affecting peri-implant bone metabolism Periodontol. 2000 (IF 18.6) Pub Date : 2023-10-30 Angel Insua, Pablo Galindo-Moreno, Richard J. Miron, Hom-Lay Wang, Alberto Monje
Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting
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The natural history of periodontal disease—Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP) Periodontol. 2000 (IF 18.6) Pub Date : 2023-10-25 Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter
In this descriptive analysis of the 21-year follow-up data from the SHIP-START cohort and the 7-year follow-up data from the SHIP-TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in SHIP-START and SHIP-TREND, respectively. At the final follow-up
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Membrane barriers for guided bone regeneration: An overview of available biomaterials Periodontol. 2000 (IF 18.6) Pub Date : 2023-10-19 Gabriel Mizraji, Alon Davidzohn, Mervi Gursoy, Ulvi Gursoy, Lior Shapira, Asaf Wilensky
Dental implants revolutionized the treatment options for restoring form, function, and esthetics when one or more teeth are missing. At sites of insufficient bone, guided bone regeneration (GBR) is performed either prior to or in conjunction with implant placement to achieve a three-dimensional prosthetic-driven implant position. To date, GBR is well documented, widely used, and constitutes a predictable
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Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity Periodontol. 2000 (IF 18.6) Pub Date : 2023-10-16 Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto
Noncommunicable diseases (NCDs) are multifactorial, long-term, chronic conditions that represent a burden to health-care systems worldwide as they can only be controlled rather than cured; hence, they require long-term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is also rapidly rising. “Multimorbidity,” defined as the presence
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Do autologous platelet concentrates (APCs) have a role in intra-oral bone regeneration? A critical review of clinical guidelines on decision-making process Periodontol. 2000 (IF 18.6) Pub Date : 2023-10-16 Marc Quirynen, Sam Siawasch, Andy Temmerman, Simone Cortellini, Rutger Dhondt, Wim Teughels, Anna B. Castro
In the past decades, personalized regenerative medicine has gained increased attention. Autologous platelet concentrates (APCs) such as PRP, PRGF, and L-PRF, all serving as a source of a large variety of cells and growth factors that participate in hard and soft tissue healing and regeneration, could play a significant role in regenerative periodontal procedures. This narrative review evaluated the
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Ion incorporation into bone grafting materials Periodontol. 2000 (IF 18.6) Pub Date : 2023-10-12 Qin Zhao, Yueqi Ni, Hongjiang Wei, Yiling Duan, Jingqiu Chen, Qi Xiao, Jie Gao, Yiqian Yu, Yu Cui, Simin Ouyang, Richard J. Miron, Yufeng Zhang, Chengtie Wu
The use of biomaterials in regenerative medicine has expanded to treat various disorders caused by trauma or disease in orthopedics and dentistry. However, the treatment of large and complex bone defects presents a challenge, leading to a pressing need for optimized biomaterials for bone repair. Recent advances in chemical sciences have enabled the incorporation of therapeutic ions into bone grafts
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3D printing for bone regeneration: challenges and opportunities for achieving predictability Periodontol. 2000 (IF 18.6) Pub Date : 2023-10-12 Saso Ivanovski, Omar Breik, Danilo Carluccio, Jamil Alayan, Ruben Staples, Cedryck Vaquette
3D printing offers attractive opportunities for large-volume bone regeneration in the oro-dental and craniofacial regions. This is enabled by the development of CAD-CAM technologies that support the design and manufacturing of anatomically accurate meshes and scaffolds. This review describes the main 3D-printing technologies utilized for the fabrication of these patient-matched devices, and reports
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Less marginal bone loss around bone-level implants restored with long abutments: A systematic review and meta-analysis Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-28 Péter Tajti, Eleonora Solyom, Szilárd Váncsa, Péter Mátrai, Péter Hegyi, Gábor Varga, Péter Hermann, Judit Borbély, Anton Sculean, Krisztina Mikulás
The aim of this study was to investigate the biological outcomes of bone-level implants restored with long vs. short abutments, with regard to the ‘one abutment at one time’ protocol. The systematic search was performed in five databases: MEDLINE (PubMed), EMBASE, Web of Science, Scopus, and CENTRAL for randomized controlled trials up to January 14, 2023. Data were collected for marginal bone loss
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Supra and subgingival application of antiseptics or antibiotics during periodontal therapy Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-28 Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil
Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient's risk factors and the debridement of supra and subgingival
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Efficacy of biomaterials for lateral bone augmentation performed with guided bone regeneration. A network meta-analysis Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-27 Elena Calciolari, Stefano Corbella, Nikolaos Gkranias, Marco Viganó, Anton Sculean, Nikolaos Donos
Bone regeneration is often required concomitant with implant placement to treat a bone fenestration, a dehiscence, and for contouring. This systematic review assessed the impact of different biomaterials employed for guided bone regeneration (GBR) simultaneous to implant placement on the stability of radiographic peri-implant bone levels at ≥12 months of follow-up (focused question 1), as well as on
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Antimicrobial effect of platelet-rich fibrin: A systematic review of in vitro evidence-based studies Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-22 Vittorio Moraschini, Richard J. Miron, Carlos Fernando de Almeida Barros Mourão, Rafael Seabra Louro, Anton Sculean, Luiz Afonso Morgenstern da Fonseca, Monica Diuana Calasans Maia, Jamil Awad Shibli
This systematic review (SR) aimed to evaluate the antimicrobial potential of different types of platelet-rich fibrin (PRF) often used in regenerative treatments. An electronic search was performed in four databases and in Gray literature for articles published until January, 2023. The eligibility criteria comprised in vitro studies that evaluated the antimicrobial effect of different types of PRF.
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Understanding exosomes: Part 1—Characterization, quantification and isolation techniques Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-22 Richard J. Miron, Yufeng Zhang
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with a diameter in the range of 30–150 nm. Their use has gained great momentum recently due to their ability to be utilized as diagnostic tools with a vast array of therapeutic applications. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically
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Lateral augmentation of the jaw by the split expansion ridge technique. A critical review Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-22 Zvi Artzi
Bone augmentation has become a routine procedure to enhance and/or repair a deficient or resorbed alveolar ridge for predictable and successful implant placement. The split expansion ridge i.e., the alveolar ridge splitting (ARS) procedure, is one of the less invasive procedures, and is characterized by minor morbidity. This would allow to widen narrow ridges in order to allow implant reconstruction
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Selecting biomaterials in the reconstructive therapy of peri-implantitis Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-20 Alberto Monje, Ramón Pons, José Nart, Richard J Miron, Frank Schwarz, Anton Sculean
Peri-implantitis is a pathogenic inflammatory condition characterized by progressive bone loss and clinical inflammation that may compromise the stability of dental implants. Therapeutic modalities have been advocated to arrest the disorder and to establish peri-implant health. Reconstructive therapy is indicated for bone defects exhibiting contained/angular components. This therapeutic modality is
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Twenty-five years of recombinant human growth factors rhPDGF-BB and rhBMP-2 in oral hard and soft tissue regeneration Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-08 Maria Elisa Galarraga-Vinueza, Shayan Barootchi, Marc L. Nevins, Myron Nevins, Richard J. Miron, Lorenzo Tavelli
Contemporary oral tissue engineering strategies involve recombinant human growth factor approaches to stimulate diverse cellular processes including cell differentiation, migration, recruitment, and proliferation at grafted areas. Recombinant human growth factor applications in oral hard and soft tissue regeneration have been progressively researched over the last 25 years. Growth factor-mediated surgical
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Optimization of platelet-rich fibrin Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-08 Richard J. Miron, Masako Fujioka-Kobayashi, Anton Sculean, Yufeng Zhang
The use of platelet-rich fibrin (PRF) has gained tremendous popularity in recent years owing to its ability to speed wound healing postsurgery. However, to date, many clinicians are unaware of methods designed to optimize the technology. This overview article will discuss the advancements and improvements made over the years aimed at maximizing cell and growth factor concentrations. First, a general
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Osteoinduction and osteoimmunology: Emerging concepts Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-01 Richard J. Miron, Marc Bohner, Yufeng Zhang, Dieter D. Bosshardt
The recognition and importance of immune cells during bone regeneration, including around bone biomaterials, has led to the development of an entire field termed “osteoimmunology,” which focuses on the connection and interplay between the skeletal system and immune cells. Most studies have focused on the “osteogenic” capacity of various types of bone biomaterials, and much less focus has been placed
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Critical review on bone grafting during immediate implant placement Periodontol. 2000 (IF 18.6) Pub Date : 2023-09-01 Antonio Liñares, José Dopico, Gabriel Magrin, Juan Blanco
In the last 20 years, immediate implant placement has been proposed as a predictable protocol to replace failing teeth. The research conducted in preclinical and clinical studies have focused on soft and hard tissue changes following tooth extraction and immediate implant placement. Different approaches for hard and soft tissue grafting together with provisional restorations have been proposed to compensate
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Bone reconstruction of extensive maxillomandibular defects in adults Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-31 Peer W. Kämmerer, Bilal Al-Nawas
Reconstruction of significant maxillomandibular defects is a challenge that has been much discussed over the last few decades. Fundamental principles were developed decades ago (bone bed viability, graft immobilization). Clinical decision-making criteria are highly relevant, including local/systemic factors and incision designs, the choice of material, grafting technique, and donor site morbidity.
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Is alveolar ridge preservation an overtreatment? Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-25 Nikos Mardas, Neil Macbeth, Nikolaos Donos, Ronald Ernst Jung, Anina Nives Zuercher
The morphology and dimensions of the postextraction alveolar ridge are important for the surgical and restorative phases of implant treatment. Adequate new bone formation and preservation of alveolar ridge dimensions following extraction will facilitate installation of the implant in a restorative position, while preservation of soft tissue contour and volume is essential for an aesthetic and implant-supported
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Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-24 P. A. Miguez, E. Bash, M. L. Musskopf, S. A. Tuin, A. Rivera-Concepcion, I. L. C. Chapple, J. Liu
Proteoglycans are core proteins associated with carbohydrate/sugar moieties that are highly variable in disaccharide composition, which dictates their function. These carbohydrates are named glycosaminoglycans, and they can be attached to proteoglycans or found free in tissues or on cell surfaces. Glycosaminoglycans such as hyaluronan, chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparin/heparan
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Nanocages and cell-membrane display technology as smart biomaterials Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-24 Yulan Wang, Richard J. Miron, Xiaoxin Zhang, Hao Zeng, Yufeng Zhang
Gold nanocages (AuNCs) have been invented and developed over two decades as biomaterial in clinical medicine with great application potential. AuNCs have a characteristic structure of porous walls with hollow interior and a compact size. This makes it possible for them to transport biomolecules or drugs with the advantages of their photothermal effects that could help further destroy germs or tumors
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Bone regeneration in implant dentistry: Which are the factors affecting the clinical outcome? Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-24 Nikolaos Donos, Aliye Akcali, Ninad Padhye, Anton Sculean, Elena Calciolari
The key factors that are needed for bone regeneration to take place include cells (osteoprogenitor and immune-inflammatory cells), a scaffold (blood clot) that facilitates the deposition of the bone matrix, signaling molecules, blood supply, and mechanical stability. However, even when these principles are met, the overall amount of regenerated bone, its stability over time and the incidence of complications
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Optimized bone grafting Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-23 Richard J. Miron
Bone grafting is routinely performed in periodontology and oral surgery to fill bone voids. While autogenous bone is considered the gold standard because of its regenerative properties, allografts and xenografts have more commonly been utilized owing to their availability as well as their differential regenerative/biomechanical properties. In particular, xenografts are sintered at high temperatures
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Can vitamins improve periodontal wound healing/regeneration? Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-17 Karim M. Fawzy El-Sayed, Raluca Cosgarea, Anton Sculean, Christof Doerfer
Periodontitis is a complex inflammatory disorder of the tooth supporting structures, associated with microbial dysbiosis, and linked to a number if systemic conditions. Untreated it can result in an irreversible damage to the periodontal structures and eventually teeth loss. Regeneration of the lost periodontium requires an orchestration of a number of biological events on cellular and molecular level
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Anatomical characteristics of the alveolar process and basal bone that have an effect on socket healing Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-02 Maurício G. Araújo, Debora R. Dias, Flavia Matarazzo
Following tooth extraction, a sequence of events takes place in order to close the wound and restore tissue homeostasis, a process called socket healing. The outcome of socket healing includes a marked reduction of the ridge dimensions. The amount of tissue loss that occurs during healing is influenced by several local and systemic factors. Thus, the aim of the present review was to describe the effect
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Simultaneous or staged lateral ridge augmentation: A clinical guideline on the decision-making process Periodontol. 2000 (IF 18.6) Pub Date : 2023-08-02 Shan-Huey Yu, Muhammad H. A. Saleh, Hom-Lay Wang
Lateral ridge augmentation is a standard surgical procedure that can be performed prior to (staged) or simultaneously with implant placement. The decision between a simultaneous or staged approach involves considering multiple variables. This paper proposed a decision-making process that serves as a guideline for choosing the best treatment choice based on the available evidence and the author's clinical
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Patient-reported outcomes for bone regenerative procedures Periodontol. 2000 (IF 18.6) Pub Date : 2023-07-26 Klaus Gotfredsen
Evidence-based dentistry used for decision-making and assessment of treatment includes three components: evidence from the literature, clinical expertise, and patient expectations. Patient satisfaction embraces affability, availability, and ability and can be examined using questionnaires or structured questions to the patient to evaluate patient perception of the treatment. The questions can be quantified
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Clinical efficacy of guided bone regeneration in peri-implantitis defects. A network meta-analysis Periodontol. 2000 (IF 18.6) Pub Date : 2023-07-25 Ausra Ramanauskaite, Kathrin Becker, Emilio A. Cafferata, Frank Schwarz
Guided bone regeneration (GBR) at peri-implantitis-related bone defects involves the placement of bone-filler particles in the intrabony defects and the application of a barrier membrane. The efficacy of different GBR-supported reconstructive measures as well as their potential superiority compared to non-GBR-supported treatment strategies for bone defects at peri-implantitis sites, however, remains
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Complications following alveolar ridge augmentation procedures Periodontol. 2000 (IF 18.6) Pub Date : 2023-07-25 Binnaz Leblebicioglu, Dimitris N. Tatakis
Oral rehabilitation through implant supported dental restorations often requires a ridge augmentation procedure (RAP) prior to implant fixture placement since tooth extraction/loss results in alveolar ridge deficiencies. Although RAP-related surgical techniques and biomaterials have been in practice for several decades, outcomes are not always predictable. Post-surgical complications experienced during
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Treatment alternatives for the rehabilitation of the posterior edentulous maxilla Periodontol. 2000 (IF 18.6) Pub Date : 2023-07-24 Gustavo Avila-Ortiz, Dániel Vegh, Khaled Mukaddam, Pablo Galindo-Moreno, Bjarni Pjetursson, Michael Payer
Rehabilitation of the edentulous maxilla with implant-supported fixed dental prostheses can represent a significant clinical challenge due to limited bone availability and surgical access, among other factors. This review addresses several treatment options to replace missing teeth in posterior maxillary segments, namely the placement of standard implants in conjunction with maxillary sinus floor augmentation
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Contemporary concepts on periodontal complications from prosthetic and restorative therapies Periodontol. 2000 (IF 18.6) Pub Date : 2023-07-19 Stefano Gracis, Arturo Llobell, Stephen J. Chu
The clinical outcome of every prosthetic and restorative procedure depends on the maintenance of a healthy periodontium. It is, therefore, important that the prosthodontist and restorative dentist cause no harm or permanent damage to the underlying hard and soft tissues when performing clinical procedures necessary to carry out the planned treatment. Several factors involved in these procedures have
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Clinical periodontal diagnosis Periodontol. 2000 (IF 18.6) Pub Date : 2023-07-14 Giovanni E. Salvi, Andrea Roccuzzo, Jean-Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang
Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior to periodontal therapy, following active therapy, and during
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Accuracy and applicability of periodontitis risk assessment tools: A critical appraisal Periodontol. 2000 (IF 18.6) Pub Date : 2023-07-13 Roberto Farina, Rodrigo Lopez, Anna Simonelli, Leonardo Trombelli
Currently, periodontal risk assessment finds application at first visit (to identify individuals at high risk of either disease incidence, if still healthy, or disease progression, if already diseased) as well as at patient monitoring after active treatment and enrolment in a supportive periodontal care program. Although the current case definition of periodontitis embeds a prognostic determination
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Complications and treatment errors related to regenerative periodontal surgery Periodontol. 2000 (IF 18.6) Pub Date : 2023-07-12 Karin Jepsen, Anton Sculean, Søren Jepsen
Regenerative periodontal surgical procedures are an important component in the treatment of advanced periodontitis. They aim to improve the long-term prognosis of teeth that are periodontally compromised by the presence of intrabony and/or furcation defects, resulting biologically in formation of root cementum, periodontal ligament, and alveolar bone and evidenced clinically by reduction of deep pockets
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The natural history of periodontal disease: The Java study—Origin, implementation, and results 35 years on Periodontol. 2000 (IF 18.6) Pub Date : 2023-06-29 Ubele Van der Velden
This review describes the origin and results of the prospective longitudinal study to test potential prognostic indicators for periodontal breakdown in a population deprived of regular dental care. Experimental gingivitis studies in individuals highly susceptible or highly resistant to periodontitis showed that bleeding on probing developed quite differently: 50% versus 18% bleeding, respectively,
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Avoiding errors and complications related to immediate implant placement in the esthetic area with a mucogingival approach Periodontol. 2000 (IF 18.6) Pub Date : 2023-06-26 Martina Stefanini, Alexandra Rendón, Alessandro Zucchelli, Matteo Sangiorgi, Giovanni Zucchelli
Immediate implant placement is considered the treatment of choice for single tooth replacement in the esthetic area. However, this treatment is associated with several critical drawbacks related to the inadequate assessment/management of the soft and hard peri-implant tissues and their subsequent remodeling, resulting in peri-implant soft-tissue defects that can lead to impaired esthetic outcomes in
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Avoiding implant-related complications in medically compromised patients with or without unhealthy lifestyle/Elevated oxidative stress Periodontol. 2000 (IF 18.6) Pub Date : 2023-06-23 Gregorio Guabello, Francesco Zuffetti, Andrea Ravidà, Matteo Deflorian, Giorgio Carta, Muhammad H. A. Saleh, Matteo Serroni, Bernhard Pommer, Georg Watzek, Luca Francetti, Tiziano Testori
Increased human life expectancy broadens the alternatives for missing teeth and played a role in the widespread use of dental implants and related augmentation procedures for the aging population. Though, many of these patients may have one or more diseases. These systemic conditions may directly lead to surgical complications, compromise implant/bone healing, or influence long-term peri-implant health
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How to avoid intraoperative and postoperative complications in maxillary sinus elevation Periodontol. 2000 (IF 18.6) Pub Date : 2023-06-21 Tiziano Testori, Lorenzo Tavelli, Riccardo Scaini, Alberto Maria Saibene, Giovanni Felisati, Shayan Barootchi, Ann Marie Decker, Matteo Antonio Deflorian, Gabriele Rosano, Stephen S. Wallace, Giovanni Zucchelli, Luca Francetti, Hom-Lay Wang
Maxillary sinus floor elevation, via the lateral approach, is one of the most predictable bone augmentation procedures performed in implant dentistry. but both intra‑ and postoperative complications can occur, and some of them are severe. Our aim is as follows: