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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair Bone Res. (IF 12.7) Pub Date : 2024-03-12 Heeseog Kang, Amy L. Strong, Yuxiao Sun, Lei Guo, Conan Juan, Alec C. Bancroft, Ji Hae Choi, Chase A. Pagani, Aysel A. Fernandes, Michael Woodard, Juhoon Lee, Sowmya Ramesh, Aaron W. James, David Hudson, Kevin N. Dalby, Lin Xu, Robert J. Tower, Benjamin Levi
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Machine Learning Did Not Outperform Conventional Competing Risk Modeling to Predict Revision Arthroplasty. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-12 Jacobien H F Oosterhoff, Anne A H de Hond, Rinne M Peters, Liza N van Steenbergen, Juliette C Sorel, Wierd P Zijlstra, Rudolf W Poolman, David Ring, Paul C Jutte, Gino M M J Kerkhoffs, Hein Putter, Ewout W Steyerberg, Job N Doornberg
Estimating the risk of revision after arthroplasty could inform patient and surgeon decision-making. However, there is a lack of well-performing prediction models assisting in this task, which may be due to current conventional modeling approaches such as traditional survivorship estimators (such as Kaplan-Meier) or competing risk estimators. Recent advances in machine learning survival analysis might
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Microwave Ablation of the Pig Growth Plate: Proof of Concept for Minimally Invasive Epiphysiodesis. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-12 Samuel O Noonan, Kyle J Miller, Stephanie Goldstein, Ellen Leiferman, James White, Chris Brace, Kenneth J Noonan
Different surgical methods for epiphysiodesis of limb length discrepancy (LLD) have been described. Although these methods are variably effective, they are associated with morbidity (pain and limp) and potential complications. Microwave ablation is a less-invasive opportunity to halt growth by selectively destroying the growth plate via thermal energy to treat LLD in children.
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Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain Bone Res. (IF 12.7) Pub Date : 2024-03-05 Feng Gao, Qimiao Hu, Wenwei Chen, Jilong Li, Cheng Qi, Yiwen Yan, Cheng Qian, Mei Wan, James Ficke, Junying Zheng, Xu Cao
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Appraisal of quality and analysis of the similarities and differences between osteoarthritis Clinical Practice Guideline recommendations: A systematic review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-05 Bimbi Gray, Alison Gibbs, Jocelyn L Bowden, Jillian P Eyles, Sandra Grace, Kim Bennell, Rinie Geenen, Sharon Kolasinski, Christian Barton, Philip G Conaghan, Timothy McAlindon, Olivier Bruyere, Quentin Géczy, David J Hunter
Clinical Practice Guidelines (CPGs) aim to support management of hip and knee osteoarthritis (OA), but recommendations are often conflicting and implementation is poor, contributing to evidence-to-practice gaps. This systematic review investigated the contextual and methodological factors contributing to conflicting recommendations for hip and knee OA. Our systematic review appraised CPGs for managing
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Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis Bone Res. (IF 12.7) Pub Date : 2024-03-04 Yuhang Liu, Ruihan Hao, Jia Lv, Jie Yuan, Xuelei Wang, Churong Xu, Ding Ma, Zhouyi Duan, Bingjun Zhang, Liming Dai, Yiyun Cheng, Wei Lu, Xiaoling Zhang
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Hip contact forces can be predicted with a neural network using only synthesised key points and electromyography in people with hip osteoarthritis. Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Bradley M. Cornish, Claudio Pizzolato, David J. Saxby, Zhengliang Xia, Daniel Devaprakash, Laura E. Diamond
To develop and validate a neural network to estimate hip contact forces (HCF), and lower body kinematics and kinetics during walking in individuals with hip osteoarthritis (OA) using synthesised anatomical key points and electromyography. To assess the capability of the neural network to detect directional changes in HCF resulting from prescribed gait modifications. A calibrated electromyography-informed
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Modulation of early osteoarthritis by tibiofemoral re-alignment in sheep Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Jan Reinhard, Tamás Oláh, Matthias W. Laschke, Lars K.H. Goebel, Gertrud Schmitt, Susanne Speicher-Mentges, Michael D. Menger, Magali Cucchiarini, Dietrich Pape, Henning Madry
To investigate whether tibiofemoral alignment influences early knee osteoarthritis (OA). We hypothesized that varus overload exacerbates early degenerative osteochondral changes, and that valgus underload diminishes early OA. Normal, over- and underload were induced by altering alignment via high tibial osteotomy in adult sheep (n = 8 each). Simultaneously, OA was induced by partial medial anterior
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Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-01 Katherine M. Arnold, Samantha R. Weaver, Elizabeth L. Zars, Daniel J. Tschumperlin, Jennifer J. Westendorf
Phlpp1 inhibition is a potential therapeutic strategy for cartilage regeneration and prevention of post-traumatic osteoarthritis (PTOA). To understand how Phlpp1 loss affects cartilage structure, cartilage elastic modulus was measured with atomic force microscopy (AFM) in male and female mice after injury. Osteoarthritis was induced in male and female Wildtype (WT) and Phlpp1 mice by destabilization
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Structural validation of the Manchester-Oxford Foot Questionnaire for use in foot and ankle surgery. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Richard Goodall, Kim Borsky, Conrad J Harrison, Matt Welck, Karan Malhotra, Jeremy N Rodrigues
The Manchester-Oxford Foot Questionnaire (MOxFQ) is an anatomically specific patient-reported outcome measure (PROM) currently used to assess a wide variety of foot and ankle pathology. It consists of 16 items across three subscales measuring distinct but related traits: walking/standing ability, pain, and social interaction. It is the most used foot and ankle PROM in the UK. Initial MOxFQ validation
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Future research priorities for soft-tissue knee injuries. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Humza T Osmani, Nicolas Nicolaou, Sanjeev Anand, Jonathan Gower, , Andrew Metcalfe, Stephen McDonnell, Faraz Siddiqui, Hayley Carter, Jonathan Room, Helen Kirbyshire, Liz Hay, Sarah Iqbal, Sushilla Gerleman
To identify unanswered questions about the prevention, diagnosis, treatment, and rehabilitation and delivery of care of first-time soft-tissue knee injuries (ligament injuries, patella dislocations, meniscal injuries, and articular cartilage) in children (aged 12 years and older) and adults.
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Monobloc dual-mobility acetabular component versus a standard single-mobility acetabular component. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Sébastien Lustig, Matthieu Cotte, Constant Foissey, Rhody D Asirvatham, Elvire Servien, Cecile Batailler
The benefit of a dual-mobility acetabular component (DMC) for primary total hip arthroplasties (THAs) is controversial. This study aimed to compare the dislocation and complication rates when using a DMC compared to single-mobility (SM) acetabular component in primary elective THA using data collected at a single centre, and compare the revision rates and survival outcomes in these two groups.
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Metal artifact reduction sequence-MRI abnormalities in asymptomatic patients with dual-mobility hip prostheses. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Nathanael D Heckmann, Brian C Chung, Kevin C Liu, Xiao T Chen, Luke R Lovro, Natalie M Kistler, Eric White, Alexander B Christ, Donald B Longjohn, Daniel A Oakes, Jay R Lieberman
Modular dual-mobility (DM) articulations are increasingly used during total hip arthroplasty (THA). However, concerns remain regarding the metal liner modularity. This study aims to correlate metal artifact reduction sequence (MARS)-MRI abnormalities with serum metal ion levels in patients with DM articulations.
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Environmental and genetic risk factors associated with total knee arthroplasty following cruciate ligament surgery. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Paul M Inclan, Robert H Brophy, Nancy L Saccone, Yinjiao Ma, Vy Pham, Elizabeth L Yanik
The purpose of this study is to determine an individual's age-specific prevalence of total knee arthroplasty (TKA) after cruciate ligament surgery, and to identify clinical and genetic risk factors associated with undergoing TKA.
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Threshold for anterior acetabular component overhang correlated with symptomatic iliopsoas impingement after total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Alexandre Baujard, Pierre Martinot, Xavier Demondion, Julien Dartus, Philippe A Faure, Julien Girard, Henri Migaud
Mechanical impingement of the iliopsoas (IP) tendon accounts for 2% to 6% of persistent postoperative pain after total hip arthroplasty (THA). The most common initiator is anterior acetabular component protrusion, where the anterior margin is not covered by anterior acetabular wall. A CT scan can be used to identify and measure this overhang; however, no threshold exists for determining symptomatic
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Cardiac function may be compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Mark R J Jenkinson, Dominic R M Meek, Rothwelle Tate, Adrian Brady, Sandy MacMillan, Helen Grant, Susan Currie
Elevated blood cobalt levels secondary to metal-on-metal (MoM) hip arthroplasties are a suggested risk factor for developing cardiovascular complications including cardiomyopathy. Clinical studies assessing patients with MoM hips using left ventricular ejection fraction (LVEF) have found conflicting evidence of cobalt-induced cardiomyopathy. Global longitudinal strain (GLS) is an echocardiography measurement
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Excessive posterior pelvic tilt from preoperative supine to postoperative standing after total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Nathanael D Heckmann, Christopher Plaskos, Edgar A Wakelin, Jim W Pierrepont, Jonathan V Baré, Andrew J Shimmin
Excessive posterior pelvic tilt (PT) may increase the risk of anterior instability after total hip arthroplasty (THA). The aim of this study was to investigate the changes in PT occurring from the preoperative supine to postoperative standing position following THA, and identify factors associated with significant changes in PT.
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Registry-based study of survivorship of cemented femoral components versus collared cementless femoral components in total hip arthroplasty in older patients with osteoarthritis. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Aida Orce Rodríguez, Paul N Smith, Paul Johnson, Michael O'Sullivan, Carl Holder, Andrew Shimmin
In recent years, the use of a collared cementless femoral prosthesis has risen in popularity. The design intention of collared components is to transfer some load to the resected femoral calcar and prevent implant subsidence within the cancellous bone of the metaphysis. Conversely, the load transfer for a cemented femoral prosthesis depends on the cement-component and cement-bone interface interaction
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Influence of the type of stem and its fixation on revision and immediate postoperative mortality in elective total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Michael Morlock, Carsten Perka, Oliver Melsheimer, Stephanie M Kirschbaum
Despite higher rates of revision after total hip arthroplasty (THA) being reported for uncemented stems in patients aged > 75 years, they are frequently used in this age group. Increased mortality after cemented fixation is often used as a justification, but recent data do not confirm this association. The aim of this study was to investigate the influence of the design of the stem and the type of
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Factors associated with decreased length of stay following robotic arm-assisted and conventional total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Andreas Fontalis, Warran Wignadasan, Fabio Mancino, Crystallynn S The, Ahmed Magan, Ricci Plastow, Fares S Haddad
Postoperative length of stay (LOS) and discharge dispositions following arthroplasty can be used as surrogate measurements for improvements in patients' pathways and costs. With the increasing use of robotic technology in arthroplasty, it is important to assess its impact on LOS. The aim of this study was to identify factors associated with decreased LOS following robotic arm-assisted total hip arthroplasty
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The size of the femoral head does not influence metal ion levels after metal-on-polyethylene total hip arthroplasty: a five-year report from a randomized controlled trial. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Kristine I Bunyoz, Georgios Tsikandylakis, Kristian Mortensen, Kirill Gromov, Maziar Mohaddes, Henrik Malchau, Anders Troelsen
In metal-on-polyethylene (MoP) total hip arthroplasty (THA), large metal femoral heads have been used to increase stability and reduce the risk of dislocation. The increased size of the femoral head can, however, lead to increased taper corrosion, with the release of metal ions and adverse reactions. The aim of this study was to investigate the relationship between the size of the femoral head and
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Clinical and radiological outcomes with an augmented baseplate for superior glenoid wear in reverse shoulder arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Jong H Park, Jong H Lee, Dae Y Kim, Hyun G Kim, Jae S Kim, Sang M Lee, Su C Kim, Jae C Yoo
This study aimed to assess the impact of using the metal-augmented glenoid baseplate (AGB) on improving clinical and radiological outcomes, as well as reducing complications, in patients with superior glenoid wear undergoing reverse shoulder arthroplasty (RSA).
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Orthopaedic management of children with spinal dysraphism. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Deepika Pinto, Sabba Hussain, Donato G Leo, Anna Bridgens, Deborah Eastwood, Yael Gelfer
Children with spinal dysraphism can develop various musculoskeletal deformities, necessitating a range of orthopaedic interventions, causing significant morbidity, and making considerable demands on resources. This systematic review aimed to identify what outcome measures have been reported in the literature for children with spinal dysraphism who undergo orthopaedic interventions involving the lower
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Changing practice to a new-generation triple-taper collared femoral component reduces periprosthetic fracture rates after primary total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Robert G Ricotti, Dimitrios A Flevas, Ruba Sokrab, Jonathan M Vigdorchik, David J Mayman, Seth A Jerabek, Thomas P Sculco, Peter K Sculco
Periprosthetic femoral fracture (PPF) is a major complication following total hip arthroplasty (THA). Uncemented femoral components are widely preferred in primary THA, but are associated with higher PPF risk than cemented components. Collared components have reduced PPF rates following uncemented primary THA compared to collarless components, while maintaining similar prosthetic designs. The purpose
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Arthroscopic suture in the management of palmar midcarpal instability. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Jean-Baptiste de Villeneuve Bargemon, Romain Mari, Christophe Mathoulin, Clément Prenaud, Lorenzo Merlini
Patients with midcarpal instability are difficult to manage. It is a rare condition, and few studies have reported the outcomes of surgical treatment. No prospective or retrospective study has reported the results of arthroscopic palmar capsuloligamentous suturing. Our aim was to report the results of a prospective study of arthroscopic suture of this ligament complex in patients with midcarpal instability
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Should high-risk patients seek out care from high-volume surgeons? Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Jeremiah Thomas, Itay Ashkenazi, Kyle W Lawrence, Roy I Davidovitch, Joshua C Rozell, Ran Schwarzkopf
Patients with a high comorbidity burden (HCB) can achieve similar improvements in quality of life compared with low-risk patients, but greater morbidity may deter surgeons from operating on these patients. Whether surgeon volume influences total hip arthroplasty (THA) outcomes in HCB patients has not been investigated. This study aimed to compare complication rates and implant survivorship in HCB patients
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Metal levels and glomerular filtration rate after unilateral Birmingham Hip Resurfacing. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Charles A Engh, Vinay Bhal, Robert H Hopper
The first aim of this study was to evaluate whether preoperative renal function is associated with postoperative changes in whole blood levels of metal ions in patients who have undergone a Birmingham Hip Resurfacing (BHR) arthroplasty with a metal-on-metal bearing. The second aim was to evaluate whether exposure to increased cobalt (Co) and chromium (Cr) levels for ten years adversely affected renal
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Long-term follow-up of an uncemented proximally hydroxyapatite-coated femoral stem in total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Andy H F Yee, Vincent W K Chan, Henry Fu, Ping-Keung Chan, Kwong Y Chiu
The aim of this study was to evaluate the survival of a collarless, straight, hydroxyapatite-coated femoral stem in total hip arthroplasty (THA) at a minimum follow-up of 20 years.
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The failure of subcategorization of cauda equina syndrome. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Nicholas V Todd, Adrian Casey, Nick C Birch
The diagnostic sub-categorization of cauda equina syndrome (CES) is used to aid communication between doctors and other healthcare professionals. It is also used to determine the need for, and urgency of, MRI and surgery in these patients. A recent paper by Hoeritzauer et al (2023) in this journal examined the interobserver reliability of the widely accepted subcategories in 100 patients with cauda
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Low rate of periprosthetic femoral fracture with the Hueter anterior approach using stems cemented according to the 'French paradox'. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Pierre Laboudie, Aurélien Hallé, Philippe Anract, Moussa Hamadouche
The aim of this retrospective study was to assess the incidence of early periprosthetic femoral fracture (PFF) associated with Charnley-Kerboull (CK) femoral components cemented according to the 'French paradox' principles through the Hueter anterior approach (HAA) in patients older than 70 years.
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The use of medial joint opening rather than mechanical axis deviation to determine the clinical outcomes after high tibial osteotomy. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Sung E Kim, Junpyo Kwak, Du H Ro, Myung C Lee, Hyuk-Soo Han
The aim of this study was to evaluate whether achieving medial joint opening, as measured by the change in the joint line convergence angle (∆JLCA), is a better predictor of clinical outcomes after high tibial osteotomy (HTO) compared with the mechanical axis deviation, and to find individualized targets for the redistribution of load that reflect bony alignment, joint laxity, and surgical technique
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Survival of cemented short Exeter femoral components in primary total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Mirthe H W van Veghel, Remy E van der Koelen, Gerjon Hannink, B W Schreurs, Wim H C Rijnen
The aim of this study was to report the long-term follow-up of cemented short Exeter femoral components when used in primary total hip arthroplasty (THA).
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Long-term polyethylene wear rates and clinical outcomes of oxidized zirconium femoral heads on highly cross-linked polyethylene in total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Brandt C Buckner, Nathanael D Urban, Kevin M Cahoy, Elizabeth R Lyden, Christopher F Deans, Kevin L Garvin
Oxidized zirconium (OxZi) and highly cross-linked polyethylene (HXLPE) were developed to minimize wear and risk of osteolysis in total hip arthroplasty (THA). However, retrieval studies have shown that scratched femoral heads may lead to runaway wear, and few reports of long-term results have been published. The purpose of this investigation is to report minimum ten-year wear rates and clinical outcomes
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Magnetically driven antegrade intramedullary lengthening nails for tibial lengthening. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Bjoern Vogt, Milena Lueckingsmeier, Georg Gosheger, Andrea Laufer, Gregor Toporowski, Carina Antfang, Robert Roedl, Adrien Frommer
As an alternative to external fixators, intramedullary lengthening nails (ILNs) can be employed for distraction osteogenesis. While previous studies have demonstrated that typical complications of external devices, such as soft-tissue tethering, and pin site infection can be avoided with ILNs, there is a lack of studies that exclusively investigated tibial distraction osteogenesis with motorized ILNs
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Optimal hip capsular release for joint exposure in hip resurfacing via the direct anterior approach. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Kabelan J Karunaseelan, Rima Nasser, Jonathan R T Jeffers, Justin P Cobb
Surgical approaches that claim to be minimally invasive, such as the direct anterior approach (DAA), are reported to have a clinical advantage, but are technically challenging and may create more injury to the soft-tissues during joint exposure. Our aim was to quantify the effect of soft-tissue releases on the joint torque and femoral mobility during joint exposure for hip resurfacing performed via
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Effectiveness of bracing to achieve curve regression in adolescent idiopathic scoliosis. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Shiyu Tang, Jason P Y Cheung, Prudence W H Cheung
To systematically evaluate whether bracing can effectively achieve curve regression in patients with adolescent idiopathic scoliosis (AIS), and to identify any predictors of curve regression after bracing.
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Accuracy of femoral component anteversion in robotic total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Nobuhiko Sugano, Yuki Maeda, Haruka Fuji, Kazunori Tamura, Nobuo Nakamura, Kazuma Takashima, Keisuke Uemura, Hidetoshi Hamada
Femoral component anteversion is an important factor in the success of total hip arthroplasty (THA). This retrospective study aimed to investigate the accuracy of femoral component anteversion with the Mako THA system and software using the Exeter cemented femoral component, compared to the Accolade II cementless femoral component.
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Clinical outcomes and return to dance after total hip arthroplasty or hip resurfacing in professional dancers. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Scott M LaValva, Drake G LeBrun, Haley G Canoles, Renee Ren, Douglas E Padgett, Edwin P Su
Professional dancers represent a unique patient population in the setting of hip arthroplasty, given the high degree of hip strength and mobility required by their profession. We sought to determine the clinical outcomes and ability to return to professional dance after total hip arthroplasty (THA) or hip resurfacing arthroplasty (HRA).
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Patient attitudes towards day-case hip and knee arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Caroline H Halken, Christian Bredgaard Jensen, Cecilie Henkel, Kirill Gromov, Anders Troelsen
This study aimed to investigate patients' attitudes towards day-case hip and knee arthroplasty and to describe patient characteristics associated with different attitudes, with the purpose of providing an insight into the information requirements for patients that surgeons should address when informing patients about day-case surgery.
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Can the Sterilization Protocol Be Improved to Enhance the Healing of Allograft Tendons? An In Vivo Study in Rabbit Tendons. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-01 Haoran Zhang, Mingyou Xu, Yiwei Zhao, Zhiyi Li, Bingtai Han, Shengru Wang, Jingyu Zhang, Jianguo Zhang, Yongcheng Hu
Peracetic acid and irradiation are common sterilization methods for allograft tendons; however, under some conditions, both methods adversely affect the fiber arrangement and ultimate load of the tendon. An in vitro study showed that low-dose peracetic acid combined with irradiation may be less detrimental to allograft tendon structure and properties, possibly because the breakdown of peracetic acid
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A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis Bone Res. (IF 12.7) Pub Date : 2024-02-29 Yong Li, Zhengwen Cai, Wenjuan Ma, Long Bai, En Luo, Yunfeng Lin
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Evolution and advancements in genomics and epigenomics in OA research: How far we have come Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-28 Yolande Ramos, Sarah J. Rice, Shabana Amanda Ali, Chiara Pastrello, Igor Jurisica, Muhammad Farooq Rai, Kelsey H. Collins, Annemarie Lang, Tristan Maerz, Jeroen Geurts, Cristina Ruiz-Romero, Ronald K. June, C. Thomas Appleton, Jason S. Rockel, Mohit Kapoor
Osteoarthritis (OA) is the most prevalent musculoskeletal disease affecting articulating joint tissues, resulting in local and systemic changes that contribute to increased pain and reduced function. Diverse technological advancements have culminated in the advent of high throughput “omic” technologies, enabling identification of comprehensive changes in molecular mediators associated with the disease
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How Much Bullying and Discrimination Are Reported by Sexual and Gender Minorities in Orthopaedics? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-02-28 Yogesh Kumaran, Jaime Bellamy, Ryann Maciejewski, Kirsten Tulchin-Francis, Julie Balch Samora
Discriminatory practices against minority populations are prominent, especially in the workplace. In particular, lesbian, gay, bisexual, transgender, and queer or questioning (LGBTQ+) individuals experience several barriers and stressors more often than individuals who do not identify as LGBTQ+. Mistreatment is common among these individuals in their personal and professional lives. However, representation
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High Expectations Among Patients Who Have Undergone TKA Do Not Correlate With Satisfaction. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-02-28 Nicole Vogel, Raphael Kaelin, Thomas Rychen, Séverin Wendelspiess, Magdalena Müller-Gerbl, Markus P Arnold
One of five patients is dissatisfied with the outcome of TKA. With the increasing number of TKAs, this affects many patients. It has been suggested that high expectations may influence satisfaction, but the relationship between preoperative patient expectations and postoperative patient satisfaction remains poorly understood.
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Hip Arthroscopy Improves Sexual Function in Receptive Partners with Femoroacetabular Impingement Syndrome. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-02-27 Nicole D Rynecki, Matthew T Kingery, Brittany DeClouette, Michael Buldo-Licciardi, Taylor Jazrawi, Jordan Eskenazi, Rae Lan, Thomas Youm
Hip pain due to femoroacetabular impingement (FAI) is thought to adversely impact sexual satisfaction because of exacerbation of symptoms with hip ROM. However, the effect of FAI on sexual satisfaction and improvement after surgery to treat FAI is largely absent from published studies, despite patients' apparent interest in it as registered by the frequent appearance of these topics on online anonymous
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Aging impairs the osteocytic regulation of collagen integrity and bone quality Bone Res. (IF 12.7) Pub Date : 2024-02-26 Charles A. Schurman, Serra Kaya, Neha Dole, Nadja M. Maldonado Luna, Natalia Castillo, Ryan Potter, Jacob P. Rose, Joanna Bons, Christina D. King, Jordan B. Burton, Birgit Schilling, Simon Melov, Simon Tang, Eric Schaible, Tamara Alliston
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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development Bone Res. (IF 12.7) Pub Date : 2024-02-23 Laura J. Brylka, Assil-Ramin Alimy, Miriam E. A. Tschaffon-Müller, Shan Jiang, Tobias Malte Ballhause, Anke Baranowsky, Simon von Kroge, Julian Delsmann, Eva Pawlus, Kian Eghbalian, Klaus Püschel, Astrid Schoppa, Melanie Haffner-Luntzer, David J. Beech, Frank Timo Beil, Michael Amling, Johannes Keller, Anita Ignatius, Timur A. Yorgan, Tim Rolvien, Thorsten Schinke
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A missed opportunity: A scoping review of the effect of sex and age on osteoarthritis using large animal models Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-24 Holly L. Stewart, Derek Gilbert, Darko Stefanovski, Zoe Garman, Michael B. Albro, Manish Bais, Mark W. Grinstaff, Brian D. Snyder, Thomas P. Schaer
The objective was to critically analyze the published literature accounting for sex differences and skeletal age (open vs. closed physis) in preclinical animal models of OA, including the disaggregation of data by sex and skeletal maturity when data is generated from combined sex and/or multi-aged cohorts without proper confounding. A scoping literature review of PubMed, Web of Science, EMBASE, and
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Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles Bone Res. (IF 12.7) Pub Date : 2024-02-22 Weicheng Lu, Jianfei Yan, Chenyu Wang, Wenpin Qin, Xiaoxiao Han, Zixuan Qin, Yu Wei, Haoqing Xu, Jialu Gao, Changhe Gao, Tao Ye, Franklin R. Tay, Lina Niu, Kai Jiao
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Reflections on 30 years of publishing osteoarthritis research: Where we’ve been and where we’re going Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Michelle S. Yau, Stephanie R. Filbay, Joel A. Block, L. Stefan Lohmander
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miR-708–5p deficiency involves the degeneration of mandibular condylar chondrocytes via the TLR4/NF-κB pathway Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Lingfeng Xu, Yuejiao Zhang, Jia Yu, Wanqiu Huo, Jiali Xu, Hongxu Yang, Mian Zhang, Shibing Yu, Yaoping Wu, Meiqing Wang
Ageing and aberrant biomechanical stimulation are two major risk factors for osteoarthritis (OA). One of the main characteristics of aged cartilage is cellular senescence. One of the main characteristics of osteoarthritic joints is cartilage degeneration. The cells in the temporomandibular joint (TMJ) cartilage are zonally arranged. The deep zone cells are differentiated from the superficial zone cells
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Alterations in compositional and cellular properties of the subchondral bone are linked to cartilage degeneration in hip osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Julian Delsmann, Julian Eissele, Alexander Simon, Assil-Ramin Alimy, Simon von Kroge, Herbert Mushumba, Klaus Püschel, Björn Busse, Christian Ries, Michael Amling, Frank Timo Beil, Tim Rolvien
The subchondral bone is an emerging regulator of osteoarthritis (OA). However, knowledge of how specific subchondral alterations relate to cartilage degeneration remains incomplete. Femoral heads were obtained from 44 patients with primary OA during total hip arthroplasty and from 30 non-OA controls during autopsy. A multiscale assessment of the central subchondral bone region comprising histomorphometry
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Assessing the degree to which randomized control trials align with the core outcome set for osteoarthritis of knee and hip: A cross-sectional analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-23 Trevon Jelinek, Alec Young, Garrett Jones, Kimberly Magana, Trevor Magee, Shaelyn Ward, Jay Modi, Kyle Fitzgerald, Griffin Hughes, Alicia Ito Ford, Matt Vassar
To assess the degree of core outcome set alignment and identify issues with alignment to the 2019 COS among clinical trial registrations focused on knee and/or hip osteoarthritis (OA). Our search was performed on registered knee and hip OA randomized controlled trials (RCTs) available on ClinicalTrials.gov and WHO International Clinical Trials Registry Platform. The screening process considered trials
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Do Women and Minority Orthopaedic Residents Report Experiencing Worse Well-being and More Mistreatment Than Their Peers? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-02-23 Katherine M Gerull, Sandra E Klein, Anna N Miller, Cara A Cipriano
Despite the increased risk of attrition for women and minority residents during orthopaedic residency, there is currently a paucity of research examining the training environment of these residents. To address this, we examined how well-being constructs may differ for women or minority residents compared with their peers, and whether these residents report experiencing more mistreatment during residency
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RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia Bone Res. (IF 12.7) Pub Date : 2024-02-20 Luis F. de Castro, Jarred M. Whitlock, Zachary Michel, Kristen Pan, Jocelyn Taylor, Vivian Szymczuk, Brendan Boyce, Daniel Martin, Vardit Kram, Rebeca Galisteo, Kamran Melikov, Leonid V. Chernomordik, Michael T. Collins, Alison M. Boyce
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Psoriasis Is a Risk Factor for Surgical Site Infection After Primary TKA. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-02-20 Caleb Durst, Lily Rajaee, Kenny Chang, Anderson Lee, Sean Rajaee
The relationship between psoriasis and complications after primary TKA is not well defined. Current studies are limited to small, single-center studies evaluating fewer than 150 patients with psoriasis, with some studies reporting an increased risk of surgical site infection (SSI) and another reporting no associated risk. There is a need to reevaluate the risk of psoriasis and postoperative complications
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Insights and implications of sexual dimorphism in osteoporosis Bone Res. (IF 12.7) Pub Date : 2024-02-18 Yuan-Yuan Zhang, Na Xie, Xiao-Dong Sun, Edouard C. Nice, Yih-Cherng Liou, Canhua Huang, Huili Zhu, Zhisen Shen
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Importance of IL-6 trans-signaling and high autocrine IL-6 production in human osteoarthritic chondrocyte metabolism Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-16 Annett Eitner, Christian König, Felix C. Kohler, Gunther O. Hofmann, Britt Wildemann, Matthias Aurich, Hans-Georg Schaible
Neutralization of Interleukin (IL)-6-signaling by antibodies is considered a promising tool for the treatment of osteoarthritis (OA). To gain further insight into this potential treatment, this study investigated the effects of IL-6-signaling and IL-6 neutralization on chondrocyte metabolism and the release of IL-6-signaling-releated mediators by human chondrocytes. Chondrocytes were collected from
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Progress in rehabilitation-related exercise for knee OA at OARSI over the past 30 years Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-13 Daniel K. White, Louise M. Thoma
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Obesity and body mass index: Past and future considerations in osteoarthritis research Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-02-12 Kristine Godziuk, Gillian A. Hawker
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties and limitations. These include an inability to discern fat and muscle mass, account for sex-differences in fat distribution, or identify adiposityrelated health impairments. A focus on BMI in OA research