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Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections Bone Res. (IF 12.7) Pub Date : 2024-05-14 Leilei Qin, Shuhao Yang, Chen Zhao, Jianye Yang, Feilong Li, Zhenghao Xu, Yaji Yang, Haotian Zhou, Kainan Li, Chengdong Xiong, Wei Huang, Ning Hu, Xulin Hu
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Response to: You et al., ‘Comment on: How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis’ Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-09 Matthew G. King, Mark J. Scholes, Iryoung Fan, Dhruv Govil, Adam I. Semciw
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Clinical practice guidelines for osteoarthritis: Caveats related to discrepancies in recommendations Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-09 Robin Christensen, Amanda E. Nelson
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Do Hounsfield Units From Intraoperative CT Scans Correlate With Preoperative Values? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-05-09 Brendan M Striano, Alexander M Crawford, Harry M Lightsey, Chierika Ukogu, Jose I Acosta Julbe, Daniel C Gabriel, Andrew J Schoenfeld, Andrew K Simpson
There is increasing interest in forecasting postoperative complications using bone density metrics. Vertebral Hounsfield unit measurements obtained from CT scans performed for surgical planning or other purposes, known as opportunistic CTs, have shown promise for their ease of measurement and the ability to target density measurement to a particular region of interest. Concomitant with the rising interest
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Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration Bone Res. (IF 12.7) Pub Date : 2024-05-07 Xinshu Zhang, Yao Xiao, Bo Hu, Yanhao Li, Shaoyang Zhang, Jian Tian, Shuo Wang, Zaijin Tao, Xinqi Zeng, Ning-Ning Liu, Baojie Li, Shen Liu
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Pannexins in the musculoskeletal system: new targets for development and disease progression Bone Res. (IF 12.7) Pub Date : 2024-05-06 Yan Luo, Shengyuan Zheng, Wenfeng Xiao, Hang Zhang, Yusheng Li
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Collaborative model of care between orthopaedics and allied healthcare professionals (CONNACT) in knee osteoarthritis: Effectiveness-implementation hybrid randomized controlled trial of a community-based, multidisciplinary, stratified intervention Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-06 Bryan Y. TAN, Yang Su-Yin, Michelle J. Pereira, Tan C. Yue, LIM C. Joo, NG Julia Poh-Hwee, Lee K. Thiam, Pua Y. Hao, Andrew M. Briggs, David J. Hunter, Soren T. Skou, Julian Thumboo, Josip Car
To compare the clinical and cost effectiveness of the Collaborative Model of Care between Orthopaedics and Allied Healthcare Professionals (CONNACT), a community-based, stratified, multidisciplinary intervention consisting of exercise, education, psychological and nutrition delivered through a chronic care model to usual hospital care in adults with knee osteoarthritis (OA). Pragmatic, parallel-arm
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DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-06 Chang Yang, Wei Dong, Yan Wang, Xiaofei Dong, Xiaoxiao Xu, Xijie Yu, Jiawei Wang
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Impact of depressive symptoms on direct medical cost among medicare recipients with knee osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-06 Heidi Y. Yang, Zoey S. Song, Jamie E. Collins, Elena Losina
Depressive symptoms are prevalent among knee osteoarthritis (KOA) patients and may lead to additional medical costs. We compared medical costs in Medicare Current Beneficiary Survey (MCBS) respondents with KOA with and without self-reported depressive symptoms. We identified a KOA cohort using ICD-9/10 diagnostic codes in both Part A and Part B claims among community-dwelling MCBS respondents from
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Unraveling sex-specific risks of knee osteoarthritis before menopause: Do sex differences start early in life? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-05-02 Paula A. Hernandez, John Churchill Bradford, Priyanka Brahmachary, Sophia Ulman, Jennifer L. Robinson, Ronald K. June, Magali Cucchiarini
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Controversies in orthopaedic oncology. Bone Joint J. (IF 4.6) Pub Date : 2024-05-01 Lee M Jeys, Joachim Thorkildsen, Vineet Kurisunkal, Ajay Puri, Pietro Ruggieri, Matthew T Houdek, Richard A Boyle, Walid Ebeid, Eduardo Botello, Guy V Morris, , Minna K Laitinen, , Adesegun Abudu, Keisuke Ae, Manish Agarwal, Vivek Ajit Singh, Toru Akiyama, Jose I Albergo, John Alexander, Bugra Alpan, Ahmed Aoude, Apichat Asavamongkolkul, William Aston, Thomas Baad-Hansen, Tessa Balach, Joseph Benevenia
Chondrosarcoma is the second most common surgically treated primary bone sarcoma. Despite a large number of scientific papers in the literature, there is still significant controversy about diagnostics, treatment of the primary tumour, subtypes, and complications. Therefore, consensus on its day-to-day treatment decisions is needed. In January 2024, the Birmingham Orthopaedic Oncology Meeting (BOOM)
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Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-30 Yu-Yang Lin, Elias H. Jbeily, Priscilla M. Tjandra, Michael C. Pride, Michael Lopez-Torres, Seif B. Elmankabadi, Connor M. Delman, Kristin K. Biris, Heejung Bang, Jill L. Silverman, Cassandra A. Lee, Blaine A. Christiansen
People who sustain joint injuries such as anterior cruciate ligament (ACL) rupture often develop post-traumatic osteoarthritis (PTOA). In human patients, ACL injuries are often treated with ACL reconstruction. However, it is still unclear how effective joint restabilization is for reducing the progression of PTOA. The goal of this study was to determine how surgical restabilization of a mouse knee
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Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-30 Elisabeth Mulrooney, Tuhina Neogi, Hanne Dagfinrud, Hilde B. Hammer, Pernille S. Pettersen, Tore K. Kvien, Karin Magnusson, Ida K. Haugen
Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored Latent class analysis determined classes of participants with hand OA from the Nor-Hand study baseline examination (2016–17) based on a biopsychosocial framework. Outcomes were hand and overall bodily pain intensity
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The efficacy and safety of a fixed-dose combination of apocynin and paeonol, APPA, in symptomatic knee OA: A double-blind, randomized, placebo-controlled, clinical trial Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-30 Asger R. Bihlet, Inger Byrjalsen, Jeppe R. Andersen, Alan Reynolds, Nicholas Larkins, Peter Alexandersen, Helene Rovsing, Robert Moots, Philip G. Conaghan
Apocynin (AP) and paeonol (PA) are low molecular weight phenolic compounds with a broad array of anti-inflammatory and immunoregulatory effects. This study assessed of a fixed-dose combination of APPA in people with symptomatic knee osteoarthritis (OA). A multi-center, randomized, placebo-controlled, double-blind phase 2a trial enrolled participants with radiographic knee OA (Kellgren-Lawrence, KL
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Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-29 Rebecca Amesbury, Hedieh Ragati-Haghi, Alexander Mathiessen, Todd Laffaye, Rebekkah I. Stein, Jamie E. Collins, C. Kent Kwoh, Jeffrey Duryea
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HSP70—A key regulator in chondrocyte homeostasis under naturally coupled hydrostatic pressure-thermal stimuli Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-26 Yanheng Guo, Theofanis Stampoultzis, Peyman Karami, Naser Nasrollahzadeh, Vijay K. Rana, Dominique P. Pioletti
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Non-invasive electroarthrography measures cartilage in live horses and correlates to direct measurements of cartilage streaming potentials in weight bearing regions of equine metacarpophalangeal joints Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-26 Adele Changoor, Martin Garon, Eric Quenneville, Pierre Savard, Michael D. Buschmann, Mark B. Hurtig
To perform non-invasive Electroarthrography (EAG) on live horses and establish relationships between EAG and direct measurements of cartilage streaming potentials in weight bearing areas of the equine metacarpophalangeal joint. EAG was performed bilaterally on the metacarpophalangeal joints of live horses (n = 3). Separate experiments used metacarpophalangeal joint explants (n = 11) to measure EAG
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Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-26 Ida Maria Balsby, Sabrina M. Nielsen, Robin Christensen, Marius Henriksen, Louise Ulff-Møller Dahl, Johannes Iuel Berg, Simon Tarp, Féline Kroon, Margreet Kloppenburg, Weiya Zhang, David J. Hunter, Henning Bliddal, Anna Døssing
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Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-26 Arman Vahabi, Hüseyin Kaya, Hakan Koray Tosyalı, Burçin Keçeci, Dündar Sabah
Malignancies involving the pelvic ring present numerous challenges, especially in the periacetabular area. Extensive resection of the pelvic region without reconstruction can lead to severe functional impairment. Numerous reconstructive options exist, but all have drawbacks. Extracorporeally irradiated autografts are one option for reconstruction after periacetabular resections; they offer the potential
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Comment on: How effective are exercises delivered digitally (requiring internet), amongst patients with hip or knee osteoarthritis? A systematic review and meta-analysis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-25 Yingang You, Qiufang Wei, Yuepeng Teng, Miaomiao Miao
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Static Versus Articulating Spacer: Does Infectious Pathogen Type Affect Treatment Success? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-25 Caitlin Grant, Jerry Chang, Emily Poehlein, Cynthia L Green, Jessica Seidelman, William Jiranek
Treatment with a static or an articulating antibiotic-containing spacer is a common strategy for treating periprosthetic joint infection (PJI), yet many patients have persistent infections after spacer treatment. Although previous studies have compared the efficacy of a static and articulating spacer for treating PJI, few studies have assessed infection control from the time of spacer implantation
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Very Few ACGME-accredited Orthopaedic Surgery Residency Programs Have Web-accessible Leave Policies Dedicated to Parental Leave for Residents, Despite ACGME Requirements. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-25 Angela M Mercurio, Olivia L Lynch, Beth E Shubin Stein, Elizabeth G Matzkin, Jo A Hannafin, Dawn LaPorte, Brittany M Ammerman
The Accreditation Council for Graduate Medical Education (ACGME) requires that all graduate medical education (GME) programs provide at least 6 paid weeks off for medical, parental, and caregiver leave to residents. However, it is unclear whether all orthopaedic residency programs have adapted to making specific parental leave policies web-accessible since the ACGME's mandate in 2022. This gap in policy
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Chondrocyte Invasion May Be a Mechanism for Persistent Staphylococcus Aureus Infection In Vitro. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-23 Jerry Chang, David Kerr, Megan Zheng, Thorsten Seyler
Recurrent bone and joint infection with Staphylococcus aureus is common. S. aureus can invade and persist in osteoblasts and fibroblasts, but little is known about this mechanism in chondrocytes. If S. aureus were able to invade and persist within chondrocytes, this could be a difficult compartment to treat.
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Corrigendum to ‘Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases’ Osteoarthritis Cartilage 30 (2022) 1050-1061 Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-21 L. Banh, K.K. Cheung, M.W.Y. Chan, E.W.K. Young, S. Viswanathan
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Association between hip muscle strength/function and hip cartilage defects in sub-elite football players with hip/groin pain Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-20 S.L. Coburn, K.M. Crossley, J.L. Kemp, F. Gassert, J. Luitjens, S.J. Warden, A.G. Culvenor, M.J. Scholes, M.G. King, P. Lawrenson, T.M. Link, J.J. Heerey
To explore associations between hip muscle strength and cartilage defects (presence and severity) on magnetic resonance imaging (MRI) in young adults with hip/groin pain participating in sub-elite football. Sub-elite football players with hip/groin pain (>6 months) completed assessments of isometric hip strength and functional task performance. Hip cartilage defects were assessed using the Scoring
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Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-20 James Turnbull, Rakesh R. Jha, Peter R.W. Gowler, Rose Ferrands-Bentley, Dong-Hyun Kim, David A. Barrett, Aliya Sarmanova, Gwen S. Fernandes, Michael Doherty, Weiya Zhang, David A. Walsh, Ana M. Valdes, Victoria Chapman
To examine associations between serum oxylipins, which regulate tissue repair and pain signalling, and knee pain/radiographic osteoarthritis (OA) at baseline and knee pain at 3 year follow-up. Baseline, and 3 year follow-up, knee pain phenotypes were assessed from 154 participants in the Knee Pain in the Community (KPIC) cohort study. Serum and radiographic Kellgren and Lawrence (KL) and Nottingham
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Contralateral Neck-shaft Angle Lower Than 130° Is Associated With Clinical Failure in Nongeriatric Individuals: Analysis of the National Femoral Neck Fracture Database of 1066 Patients. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-19 Dajun Jiang, Hongyi Zhu, Jiaqing Cao, Qianying Cai, Feng Wu, Xiaolin Li, Kaifu Wang, Weitao Jia
Treatment of femoral neck fractures in patients who are nongeriatric (≤ 60 years) is challenging because of high failure rates. Anatomic parameters influence the biomechanical environment for fracture healing, but their associations with clinical prognosis remains unclear.
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Human Infrapatellar Fat Pad Mesenchymal Stem Cell-derived Extracellular Vesicles Purified by Anion Exchange Chromatography Suppress Osteoarthritis Progression in a Mouse Model. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-19 Qisong Liu, Jianqun Wu, Hua Wang, Zhaofeng Jia, Guangheng Li
Extracellular vesicles derived from mesenchymal stem cells (MSCs) show great promise in treating osteoarthritis (OA). However, studies from the perspective of clinical feasibility that consider an accessible cell source and a scalable preparation method for MSC-extracellular vesicles are lacking.
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Mild exercise expedites joint clearance and slows joint degradation in a joint instability model of osteoarthritis in male rats Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-18 Jarred M. Kaiser, Fabrice C. Bernard, Krishna Pucha, Sarvgna K. Raval, Tracy Eng, Travis Fulton, Shannon E. Anderson, Kyle D. Allen, J. Brandon Dixon, Nick J. Willett
Exercise remains a hallmark treatment for post-traumatic osteoarthritis (PTOA) and may maintain joint homeostasis in part by clearing inflammatory cytokines, cells, and particles. It remains largely unknown whether exercise-induced joint clearance can provide therapeutic relief of PTOA. In this study, we hypothesized that exercise could slow the progression of preclinical PTOA in part by enhancing
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Osteochondral fluid transport in an ex vivo system Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-15 Brady David Hislop, Ara K. Mercer, Alexandria G. Whitley, Erik P. Myers, Marie Mackin, Chelsea M. Heveran, Ronald K. June
Alterations to bone-to-cartilage fluid transport may contribute to the development of osteoarthritis (OA). Larger biological molecules in bone may transport from bone-to-cartilage ( insulin, 5 kDa). However, many questions remain about fluid transport between these tissues. The objectives of this study were to (1) test for diffusion of 3 kDa molecular tracers from bone-to-cartilage and (2) assess potential
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Adiposity and cartilage lesions following ACL reconstruction Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-15 Harvi F. Hart, Kay M. Crossley, Brooke E. Patterson, Ali Guermazi, Trevor B. Birmingham, Chris Koskoletos, Amélie Michaud, Alysha De Livera, Adam G. Culvenor
To determine if global, central, or peripheral adiposity is associated with prevalent and worsening cartilage lesions following anterior cruciate ligament reconstruction (ACLR). In 107 individuals one-year post-ACLR, adiposity was assessed globally (body mass index), centrally (waist circumference), and peripherally (knee subcutaneous adipose tissue thickness) from magnetic resonance imaging (MRI)
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Assessing the efficacy of the Stop OsteoARthritis (SOAR) program: A randomized delayed-controlled trial in persons at increased risk of early onset post-traumatic knee osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-12 Justin M. Losciale, Linda K. Truong, Kexin Zhang, Trish Silvester-Lee, Maxi Miciak, Andrea Pajkic, Christina Y. Le, Hui Xie, Alison M. Hoens, Amber D. Mosewich, Michael A. Hunt, Linda C. Li, Ewa M. Roos, Jackie L. Whittaker
Assess the efficacy of an 8-week virtual, physiotherapist (PT)-guided knee health program (Stop OsteoARthritis (SOAR)) to improve knee extensor strength in individuals at risk of post-traumatic knee osteoarthritis (PTOA). In this superiority, randomized delayed-control trial, persons aged 16–35 years, 1–4 years after a self-reported knee joint injury were randomly assigned (1:1) to receive the SOAR
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Elevated nutrient availability enhances chondrocyte metabolism and biosynthesis in tissue-engineered cartilage Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-12 Roberto Tarantino, Halie Mei Jensen, Stephen D. Waldman
Chondrocytes, which typically rely on anaerobic metabolism, exhibit upregulated biosynthetic activity when subjected to conditions that elicit mixed aerobic-anaerobic metabolism. Previously, we observed that increasing media volume resulted in the transition from anaerobic to mixed aerobic-anaerobic metabolism. Maximal extracellular matrix (ECM) accumulation occurred at this transition as a result
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Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization Bone Res. (IF 12.7) Pub Date : 2024-04-10 Longqing Wang, Wenhao Jiang, Siyuan Zhao, Dong Xie, Qing Chen, Qi Zhao, Hao Wu, Jian Luo, Lili Yang
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Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration Bone Res. (IF 12.7) Pub Date : 2024-04-09 Dandan Wang, Yaru Guo, Boon Chin Heng, Xuehui Zhang, Yan Wei, Ying He, Mingming Xu, Bin Xia, Xuliang Deng
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Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-09 Min Kyu Mark Kim, Matthew Lawrence, Diana Quinonez, Courtney Brooks, Rithwik Ramachandran, Cheryle A. Séguin
Transient receptor potential vanilloid 4 (TRPV4) is a multi-modally activated cation channel that mediates mechanotransduction pathways by which musculoskeletal tissues respond to mechanical load and regulate tissue health. Using conditional knockout mice, we investigated the role of in regulating intervertebral disc (IVD) health and injury-induced IVD degeneration. ( KO) mice were used to knockout
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Sex differences in osteoarthritis prevalence, pain perception, physical function and therapeutics Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-06 Neil A. Segal, Jeannine M. Nilges, Win Min Oo
Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses than men. However, the underlying factors and therapeutic outcomes of these sex-specific differences are incompletely researched. This review examines the current state of knowledge regarding sex differences in OA prevalence, risk factors, pain severity, functional outcomes, and use and response to therapeutics. PubMed
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Pioneering a chick embryo model to explore the intrauterine etiology of developmental dysplasia of the hip in oligohydramnios conditions Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-06 Shaoting Luo, Yufan Chen, Weizheng Zhou, Federico Canavese, Lianyong Li
To explore the impact of oligohydramnios on fetal movement and hip development, given its association with developmental dysplasia of the hip (DDH) but unclear mechanisms. Chick embryos were divided into four groups based on the severity of oligohydramnios induced by amniotic fluid aspiration (control, 0.2 mL, 0.4 mL, 0.6 mL). Fetal movement was assessed by detection of movement and quantification
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How Did Black and Hispanic Orthopaedic Applicants and Residents Compare to General Surgery Between 2015 and 2022? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-04 Alisha J Williams, Julia I Malewicz, John M Pum, David Zurakowski, Charles S Day
Despite the heavy demand for and knowledge of the benefits of diversity, there is a persistent lack of racial, ethnic, and gender diversity in orthopaedic surgery. Since the implementation of diversity initiatives, data have shown that general surgery has been one of the top competitive surgical fields and has demonstrated growth in racial, ethnic, and gender diversity, making general surgery a good
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High Area Deprivation Index is Associated With Not Achieving the Patient-acceptable Symptom State After TKA. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-03 Matthew J Hadad, Ignacio Pasqualini, Alison K Klika, Yuxuan Jin, Matthew E Deren, Viktor E Krebs, Trevor G Murray, Nicolas S Piuzzi
The Area Deprivation Index (ADI) approximates a patient's relative socioeconomic deprivation. The ADI has been associated with increased healthcare use after TKA, but it is unknown whether there is an association with patient-reported outcome measures (PROMs). Given that a high proportion of patients are dissatisfied with their results after TKA, and the large number of these procedures performed,
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Exploring the association of gender role expectations of pain and measures of pain sensitization in people with knee osteoarthritis: A cross-sectional study Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-02 Y.V. Raghava Neelapala, Saurab Sharma, Lisa C. Carlesso
First, we explored the association between Gender Role Expectations of Pain (GREP), and psychophysical measures of sensitization in people with knee osteoarthritis (OA). Second, we explored whether the association differed by level of GREP items (high vs low scores). We conducted secondary analyses of a cohort study. Those who were (i) age of ≥40, English or French speaking, ii) diagnosed with knee
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Post-traumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: Secondary analysis of a randomized controlled trial Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-02 Sabine J.A. van der Graaff, Edwin H.G. Oei, Max Reijman, Lars Steenbekkers, Marienke van Middelkoop, Rianne A. van der Heijden, Duncan E. Meuffels, STARR Study Group
To assess the presence of early degenerative changes on Magnetic Resonance Imaging (MRI) 24 months after a traumatic meniscal tear and to compare these changes in patients treated with arthroscopic partial meniscectomy or physical therapy plus optional delayed arthroscopic partial meniscectomy. We included patients aged 18–45 years with a recent onset, traumatic, MRI verified, isolated meniscal tear
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The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice Bone Res. (IF 12.7) Pub Date : 2024-04-01 Han Wang, Xiumin Chen, Xiaolu Meng, Yixuan Cao, Shirui Han, Keqiang Liu, Ximeng Zhao, Xiuli Zhao, Xue Zhang
Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifth metacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) of HOXD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlying pathogenic mechanism
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Skeletal interoception in osteoarthritis Bone Res. (IF 12.7) Pub Date : 2024-04-01 Dinglong Yang, Jiawen Xu, Ke Xu, Peng Xu
The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the organism. Among its various forms, skeletal interoception specifically regulates the metabolic homeostasis of bones. Osteoarthritis (OA) is a complex joint disorder involving cartilage, subchondral bone, and synovium. The subchondral
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Development and validation of a trauma frailty scale in severely injured patients: the Nottingham Trauma Frailty Index. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Abdullah G Alqarni, Jessica Nightingale, Alan Norrish, John R F Gladman, Benjamin Ollivere
Frailty greatly increases the risk of adverse outcome of trauma in older people. Frailty detection tools appear to be unsuitable for use in traumatically injured older patients. We therefore aimed to develop a method for detecting frailty in older people sustaining trauma using routinely collected clinical data.
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The rate of nonunion in the MRI-detected occult scaphoid fracture. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Benjamin J F Dean, Nicholas Riley, Christopher Little, Warren Sheehan, Sam Gidwani, Mark Brewster, Paula Dhiman, Matt L Costa
There is a lack of published evidence relating to the rate of nonunion seen in occult scaphoid fractures, diagnosed only after MRI. This study reports the rate of delayed union and nonunion in a cohort of patients with MRI-detected acute scaphoid fractures.
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Prognostic factors for clinical outcomes after arthroscopic treatment of traumatic central tears of the triangular fibrocartilage complex. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Jae-Yong Cho, Sung-Woo Lee, Do-Hyun Kim, Won-Taek Oh, Il-Hyun Koh, Yong-Min Chun, Yun-Rak Choi
The study aimed to assess the clinical outcomes of arthroscopic debridement and partial excision in patients with traumatic central tears of the triangular fibrocartilage complex (TFCC), and to identify prognostic factors associated with unfavourable clinical outcomes.
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Unveiling the learning curve of periacetabular osteotomy. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Marco Haertlé, Nils Becker, Henning Windhagen, Sufian S Ahmad
Periacetabular osteotomy (PAO) is widely recognized as a demanding surgical procedure for acetabular reorientation. Reports about the learning curve have primarily focused on complication rates during the initial learning phase. Therefore, our aim was to assess the PAO learning curve from an analytical perspective by determining the number of PAOs required for the duration of surgery to plateau and
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Two-stage revision for periprosthetic joint infection after hip and knee arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Jennifer Straub, Kevin Staats, Klemens Vertesich, Lars Kowalscheck, Reinhard Windhager, Christoph Böhler
Histology is widely used for diagnosis of persistent infection during reimplantation in two-stage revision hip and knee arthroplasty, although data on its utility remain scarce. Therefore, this study aims to assess the predictive value of permanent sections at reimplantation in relation to reinfection risk, and to compare results of permanent and frozen sections.
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Acetabular Fractures in older patients Intervention Trial (AceFIT): a feasibility triple-arm randomized controlled study. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Andrew Carrothers, Ronan O'Leary, Peter Hull, Daud Chou, Joseph Alsousou, Joseph Queally, Simon J Bond, Matthew L Costa
To assess the feasibility of a randomized controlled trial (RCT) that compares three treatments for acetabular fractures in older patients: surgical fixation, surgical fixation and hip arthroplasty (fix-and-replace), and non-surgical treatment.
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Cemented dual-mobility constructs in uncemented revision acetabular components. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Jacob M Wilson, Robert T Trousdale, Nicholas A Bedard, David G Lewallen, Daniel J Berry, Matthew P Abdel
Dislocation remains a leading cause of failure following revision total hip arthroplasty (THA). While dual-mobility (DM) bearings have been shown to mitigate this risk, options are limited when retaining or implanting an uncemented shell without modular DM options. In these circumstances, a monoblock DM cup, designed for cementing, can be cemented into an uncemented acetabular shell. The goal of this
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A prospective randomized controlled trial comparing CT-based planning with conventional total hip arthroplasty versus robotic arm-assisted total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Andreas Fontalis, Babar Kayani, Ricci Plastow, Dia E Giebaly, Jenni Tahmassebi, Isabella C Haddad, Alastair Chambers, Fabio Mancino, Sujith Konan, Fares S Haddad
Achieving accurate implant positioning and restoring native hip biomechanics are key surgeon-controlled technical objectives in total hip arthroplasty (THA). The primary objective of this study was to compare the reproducibility of the planned preoperative centre of hip rotation (COR) in patients undergoing robotic arm-assisted THA versus conventional THA.
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Do breast cancer patients have increased risk of complications after primary total hip and total knee arthroplasty? Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Cameron K Ledford, Matthew B Shirley, Mark J Spangehl, Daniel J Berry, Matthew P Abdel
Breast cancer survivors have known risk factors that might influence the results of total hip arthroplasty (THA) or total knee arthroplasty (TKA). This study evaluated clinical outcomes of patients with breast cancer history after primary THA and TKA.
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Revision total hip arthroplasty using a modular fluted, tapered revision femoral component and interlocking screws in Vancouver B3 periprosthetic fractures with insufficient bone at the isthmus. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Bernd Fink, Arman Ahmadian, Florian H Sax, Philipp Schuster
Revision total hip arthroplasty in patients with Vancouver type B3 fractures with Paprosky type IIIA, IIIB, and IV femoral defects are difficult to treat. One option for Paprovsky type IIIB and IV defects involves modular cementless, tapered, revision femoral components in conjunction with distal interlocking screws. The aim of this study was to analyze the rate of reoperations and complications and
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Bone support of a custom triflange acetabular component over time. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Erim Özdemir, Bram de Lange, Constantinus F M Buckens, Wim H C Rijnen, Jetze Visser
To investigate the extent of bone development around the scaffold of custom triflange acetabular components (CTACs) over time.
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How modular porous metal augments have changed the management of acetabular bone loss at primary or revision total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Neil P Sheth, Stephen A Jones, Sahil A Sanghavi, Andrew Manktelow
The advent of modular porous metal augments has ushered in a new form of treatment for acetabular bone loss. The function of an augment can be seen as reducing the size of a defect or reconstituting the anterosuperior/posteroinferior columns and/or allowing supplementary fixation. Depending on the function of the augment, the surgeon can decide on the sequence of introduction of the hemispherical shell
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Patient-reported outcome measures in hip fracture patients. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Cato Kjærvik, Jan-Erik Gjertsen, Eva Stensland, Eva H Dybvik, Odd Soereide
The aims of this study were to assess quality of life after hip fractures, to characterize respondents to patient-reported outcome measures (PROMs), and to describe the recovery trajectory of hip fracture patients.
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Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx Bone Res. (IF 12.7) Pub Date : 2024-03-29 Ziqian Xiang, Pengfei Zhang, Chunwang Jia, Rongkun Xu, Dingren Cao, Zhaoning Xu, Tingting Lu, Jingwei Liu, Xiaoxiong Wang, Cheng Qiu, Wenyang Fu, Weiwei Li, Lei Cheng, Qiang Yang, Shiqing Feng, Lianlei Wang, Yunpeng Zhao, Xinyu Liu
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Studies on postoperative outcome prognostic factors reveal intrinsic nature of osteoarthritis as a systemic disease: Comment on Osteoarthritis and Cartilage 2023;24(1):98–107 Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-29 E.V. Tchetina, E.A. Taskina
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What is the Long-term Wear of a 5-Mrad Highly Crosslinked Polyethylene Liner? A 14-year RSA Study. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-28 Stuart A Callary, Deepti K Sharma, Taisha M D'Apollonio, Owain Critchley, Graham Mercer, Christopher Wilson, David G Campbell
Lower doses of irradiation (≤ 5 Mrad) during the manufacture of highly crosslinked polyethylene acetabular liners may result in less crosslinking and an increased wear rate. Radiostereometric analysis (RSA) studies have found that wear of more highly irradiated highly crosslinked polyethylene liners (7 to 10 Mrad) decreases at longer-term follow-up compared with earlier reports of the same cohorts