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Evaluation of Weight Loss Counsel for Osteoarthritis Patients: A Cross-Sectional Analysis of NHANES 2011-2018 Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-28 Steven R. Carlson, Nareena Imam, Ari Seidenstein, Gregg Klein
Objective Though health care providers (HCPs) know the importance of weight loss counsel for Osteoarthritis (OA), little is known about how frequently it is practiced and even less of its effectiveness. Thus, we analyzed the prevalence and effectiveness of weight counsel receipt in overweight/obese OA patients. Design Using 2011-2018 National Health and Nutrition Examination Survey (NHANES) data, we
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Defining Patient-relevant Thresholds and Change Scores for the HOOS JR and KOOS JR Anchored on the Patient-acceptable Symptom State Question. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-29 Mihir S Dekhne, Mark A Fontana, Sohum Pandey, Daniel A Driscoll, Stephen Lyman, Alexander S McLawhorn, Catherine H MacLean
When evaluating the results of clinical research studies, readers need to know that patients perceive effect sizes, not p values. Knowing the minimum clinically important difference (MCID) and the patient-acceptable symptom state (PASS) threshold for patient-reported outcome measures helps us to ascertain whether our interventions result in improvements that are large enough for patients to care about
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Are Dental Procedures Associated With Pyogenic Vertebral Osteomyelitis? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-28 Soichiro Masuda, Toshiki Fukasawa, Masato Takeuchi, Korenori Arai, Shunsuke Fujibayashi, Bungo Otsuki, Koichi Murata, Takayoshi Shimizu, Shuichi Matsuda, Koji Kawakami
Dental procedures can lead to bacteremia and have been considered a potential risk factor for pyogenic vertebral osteomyelitis (PVO). However, data on the association between dental procedures and PVO are limited.
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Loss of Notch signaling in skeletal stem cells enhances bone formation with aging Bone Res. (IF 12.7) Pub Date : 2023-09-27 Lindsey H. Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V. Nayak, Paulo El Parente, Margaux Sambon, Pablo J. Atria, Mohamed A. E. Ali, Lukasz Witek, Alesha B. Castillo, Christopher Y, Park, Ralf H. Adams, Aristotelis Tsirigos, Sophie M. Morgani, Philipp Leucht
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Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-27 Dylan C Dean, Wenlong Feng, Robert L Walker, Pichaya Thanindratarn, H Thomas Temple, Jonathan C Trent, Andrew E Rosenberg, Francis J Hornicek, Zhenfeng Duan
Liposarcoma is the most commonly diagnosed subtype of soft tissue sarcoma. As these tumors often arise near vital organs and neurovascular structures, complete resection can be challenging; consequently, recurrence rates are high. Additionally, available chemotherapeutic agents have shown limited benefit and substantial toxicities. There is, therefore, a clear and unmet need for novel therapeutics
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Microscopic and transcriptomic changes in porcine synovium one year following disruption of the anterior cruciate ligament Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-22 Jonah I. Donnenfield, Braden C. Fleming, Benedikt L. Proffen, Archana Podury, Martha M. Murray
Objective There is no disease-modifying treatment for posttraumatic osteoarthritis (PTOA). This may be partly due to an incomplete understanding of synovitis, which has been causally linked to PTOA progression. The microscopic and transcriptomic changes in synovium seen in early- to mid-stage PTOA were evaluated to better characterize this knowledge gap. Methods Seventy-two Yucatan minipigs underwent
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Serum Proteomic Biomarkers Diagnostic of Knee Osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-19 Virginia Byers Kraus, Alexander Reed, Erik J Soderblom, Yvonne M. Golightly, Amanda E. Nelson, Yi-Ju Li
Objective To better understand the pathogenesis of knee osteoarthritis (OA) through identification of serum diagnostics. Design We conducted multiple reaction monitoring mass spectrometry analysis of 107 peptides in baseline sera of two cohorts: the Foundation for NIH (n=596 Kellgren-Lawrence (KL) grade 1-3 knee OA participants); and the Johnston County Osteoarthritis Project (n=127 multi-joint controls
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Osteomodulin downregulation is associated with osteoarthritis development Bone Res. (IF 12.7) Pub Date : 2023-09-20 Jérémie Zappia, Qiao Tong, Renée Van der Cruyssen, Frederique M. F. Cornelis, Cécile Lambert, Tiago Pinto Coelho, Juliane Grisart, Erika Kague, Rik J. Lories, Marc Muller, Dirk Elewaut, Chrissy L. Hammond, Christelle Sanchez, Yves Henrotin
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Intracluster correlation coefficients in osteoarthritis cluster randomized trials: a systematic review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-17 Lauren K. King, Nicolas S. Bodmer, Pakeezah Saadat, Pavlos Bobos, Gillian A. Hawker, Bruno R. da Costa
Objectives The design, analysis and interpretation of cluster randomized clinical trials (RCTs) requires accounting for potential correlation of observations on individuals within the same cluster. Reporting of observed intracluster correlation coefficients (ICCs) in cluster RCTs, as recommended by CONSORT, facilitates sample size calculation of future cluster RCTs and understanding of the trial statistical
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Streamlining quantitative joint-wide medial femoro-tibial histopathological scoring of mouse post-traumatic knee osteoarthritis models Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-15 Patrick Haubruck, Raban Heller, Carina L. Blaker, Elizabeth C. Clarke, Susan M. Smith, Daniel Burkhardt, Yolanda Liu, Shihani Stoner, Sanaa Zaki, Cindy C. Shu, Christopher B. Little
Objective Histological scoring remains the gold-standard for quantifying post-traumatic osteoarthritis (ptOA) in animal models, allowing concurrent evaluation of numerous joint tissues. Available systems require scoring multiple sections/joint making analysis laborious and expensive. We investigated if a single section allowed equivalent quantitation of pathology in different joint tissues and disease
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Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-15 Rachel F. Bergman, Lindsey Lammlin, Lucas Junginger, Easton Farrell, Sam Goldman, Rose Darcy, Cody Rasner, Alia M. Obeidat, Anne-Marie Malfait, Rachel E. Miller, Tristan Maerz
Objective Osteoarthritis is a disease with sex-dependent prevalence and severity in both humans and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (ACLR) mouse model of post-traumatic osteoarthritis (PTOA). Design Male and female 12-week-old C57/BL6J
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Metabolic Phenotypes Reflect Patient Sex and Injury Status: A Cross-Sectional Analysis of Human Synovial Fluid Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-15 Hope D. Welhaven, Avery H. Welfley, Prayag Pershad, James Satalich, Robert O'Connell, Brian Bothner, Alexander R. Vap, Ronald K. June
Objective Osteoarthritis is a heterogeneous disease. The objective was to compare differences in underlying cellular mechanisms and endogenous repair pathways between synovial fluid from male and female participants with different injuries to improve current understanding of the pathophysiology of downstream post-traumatic osteoarthritis. Design Synovial fluid from n=33 knee arthroscopy patients between
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Advanced glycation end products promote intervertebral disc degeneration by transactivation of matrix metallopeptidase genes Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-15 Changchun Tseng, Bin Chen, Yingchao Han, Kun Wang, Qingxin Song, Hongxing Shen, Zhi Chen
Objective Examine the mechanism by which advanced glycation end products (AGEs) induce intervertebral disc (IVD) degeneration (IDD) in C57BL/6J mice. Methods Matrix metallopeptidase (MMP) gene mRNA levels were assessed using RT-qPCR. Immunoprecipitation and co-immunoprecipitation were performed to identify the transcriptional complex regulating MMP expression due to AGEs. The preventive effects of
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Hip geometric parameters are associated with radiographic and clinical hip osteoarthritis: findings from a cross-sectional study in UK Biobank Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-11 SV Heppenstall, R Ebsim, FR Saunders, C Lindner, JS Gregory, RM Aspden, NC Harvey, T Cootes, JH Tobias, M Frysz, BG Faber
Objectives To examine the extent to which geometric parameters derived from dual-energy x-ray absorptiometry (DXA) scans in the UK Biobank study are related to hip osteoarthritis (HOA) independently of sex, age and body size. Design Femoral neck width (FNW), diameter of the femoral head (DFH) and hip axis length (HAL) were derived automatically from left hip DXA scans in UK Biobank using outline points
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Minimal important change and difference in health outcome: an overview of approaches, concepts, and methods Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-14 Joost Dekker, Michiel de Boer, Raymond Ostelo
Objective To provide an overview of approaches, concepts and methods used to define and assess minimal important change and difference in health outcome. Method A narrative review of the literature, guided by a conceptual framework. Results We distinguish between (i) interpretation of health outcome in individuals versus groups, (ii) change within individuals or groups versus difference between change
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Exploring Different Models of Pain Phenotypes and Their Association with Pain Worsening in People with Early Knee Osteoarthritis: The MOST Cohort Study Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-13 Y V Raghava Neelapala, Tuhina Neogi, Deepak Kumar, Mohamed Jarraya, Luciana Macedo, Dylan Kobsar, Steven Hanna, Laura A Frey-Law, Cora E Lewis, Michael Nevitt, Tom Appleton, Trevor Birmingham, Lisa Carlesso
Objectives To determine i) pain phenotypes (PP) in people with early-stage knee osteoarthritis (EKOA); ii) the longitudinal association between the phenotypes and pain worsening at two years. Design We studied participants with EKOA from the Multicenter Osteoarthritis Study defined as: pain intensity ≤3/10, Kellgren and Lawrence grade ≤2, intermittent pain none to sometimes and no constant pain. Two
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Which Knee Phenotypes Exhibit the Strongest Correlation With Cartilage Degeneration? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-13 Farouk Khury, Moritz Oltmanns, Theresa Unseld, Michael Fuchs, Heiko Reichel, Martin Faschingbauer
Although articular wear has been thoroughly investigated, the effects of abnormal limb alignment on cartilage degeneration over time remain poorly understood. An exact assessment of the correlation between lower limb alignment abnormalities and MRI-observed articular degradation may be helpful for understanding the progression of osteoarthritis and planning future treatment.
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Forecasting the future burden of primary total shoulder replacement in Australia Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-09 Connor Fisher, Sze-Ee Soh, Richard S Page, Richard de Steiger, Alana R Cuthbert, Ilana N Ackerman
Objective To forecast the number of primary total shoulder replacements (TSR) in Australia to the year 2035, and associated costs. Methods De-identified TSR data for 2009-2019 were obtained from the Australian Orthopaedic Association National Joint Replacement Registry. Population data, including population projections to 2035, were obtained from the Australian Bureau of Statistics. Three forecasting
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OARSI Year in Review 2023: Rehabilitation and Outcomes Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-09-04 EM Macri, RW Selles, JJ Stefanik, M Reijman
Objective We systematically reviewed the literature to identify comparative studies of core treatments (exercise, education, or weight management), adjunct treatments (e.g. electrotherapeutical modalities, bracing), or multimodal treatments (core plus other treatments), for treating osteoarthritis (OA) complaints, published between 1 March 2022 and 1 March 2023. Design We searched three electronic
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Variations in 1-year Trajectories of Levels of Pain and Capability After Shoulder Arthroplasty Are Associated with Baseline Mental Health. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-07 Melle Martijn Broekman, Niels Brinkman, Daniel Swanson, David Ring, Michel van den Bekerom, Andrew Jawa
There is variability in the trajectories of pain intensity and magnitude of incapability after shoulder arthroplasty. A better understanding of the degree to which variation in recovery trajectories relates to aspects of mental health can inform the development of comprehensive biopsychosocial care strategies.
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Is Tension Band Wire Fixation Superior to Plate Fixation for Simple Displaced Olecranon Fractures? A Randomized Trial With Median Follow-up of 7.5 Years. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-07 Erez Avisar, Ahmad Essa, Adva Gutman-Tirosh, Moshe Dahan, Eran Assaraf, Jonathan Persitz
Surgeons disagree about the best surgical treatment for simple, displaced olecranon fractures. Although the tension band wiring technique and plate fixation are the most common surgical options for fixation, studies comparing both are limited. To date, there have been no randomized trials comparing patient-reported outcomes and complications at more than 5 years of follow-up.
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Is a Novel Fluoroscopic Intraoperative Reference System Superior to Conventional Management for Distal Radius Fracture Reduction? A Propensity-matched Comparative Study. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-06 Sho Kohyama, Yuichi Yoshii, Akira Ikumi, Takeshi Ogawa, Tomoo Ishii
Preoperative planning is generally performed to simulate the process of reduction as well as to determine the size and placement of implants in patients undergoing distal radius fracture surgery. We previously described a three-dimensional (3D) digital preoperative planning system for the osteosynthesis of distal radius fractures, and we have developed a novel intraoperative referencing system that
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Interoceptive regulation of skeletal tissue homeostasis and repair Bone Res. (IF 12.7) Pub Date : 2023-09-05 Yao Xiao, Changhao Han, Yunhao Wang, Xinshu Zhang, Rong Bao, Yuange Li, Huajiang Chen, Bo Hu, Shen Liu
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No Difference Between One-shot Co-injection of Corticosteroids and Hyaluronic Acid in a Three-injection Regimen for Knee Osteoarthritis: A Randomized, Double-blind Trial. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-05 Ru-Lan Hsieh, Wen-Chung Lee
Although many guidelines now recommend against hyaluronic acid (HA) injections alone for the nonoperative management of knee osteoarthritis (OA), prior studies have disagreed about whether adding an intra-articular corticosteroid to HA results in sufficient benefit to justify the potential dose-dependent and time-dependent chondrotoxicity of corticosteroids.
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What Are the Mortality, Infection, and Nonunion Rates After Periprosthetic Femoral Fractures in the United States? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-05 Nike Walter, Dominik Szymski, Steven M Kurtz, Volker Alt, David W Lowenberg, Edmund C Lau, Markus Rupp
Periprosthetic femoral fractures are a serious complication that put a high burden on patients. However, comprehensive analyses of their incidence, mortality, and complication rates based on large-registry data are scarce.
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Allograft or Synthetic Mesh Extensor Mechanism Reconstruction After TKA Carries a High Risk of Infection, Revision, and Extensor Lag. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-09-05 Colin M Baker, Graham S Goh, Qudratullah Qadiri, Saad Tarabichi, Peter A Gold, P Maxwell Courtney
Extensor mechanism disruption is a devastating complication after TKA. Extensor mechanism reconstruction can be performed using an allograft or synthetic mesh. Recent studies have disagreed about the durability of these reconstructions. Evaluating a larger series of reconstructions that use current popular techniques and principles provides information to guide patient and surgeon expectations while
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Can CT-based gap and step-off displacement predict outcome after nonoperative treatment of acetabular fractures? Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Neeltje M Trouwborst, Kaj Ten Duis, Hester Banierink, Job N Doornberg, Sven H van Helden, Erik Hermans, Esther M M van Lieshout, Robert Nijveldt, Tjarda Tromp, Vincent M A Stirler, Michael H J Verhofstad, Jean Paul P M de Vries, Mathieu M E Wijffels, Inge H F Reininga, Frank F A IJpma
The aim of this study was to investigate the association between fracture displacement and survivorship of the native hip joint without conversion to a total hip arthroplasty (THA), and to determine predictors for conversion to THA in patients treated nonoperatively for acetabular fractures.
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Four weeks versus six weeks of immobilization in a cast following closed reduction for displaced distal radial fractures in adult patients: a multicentre randomized controlled trial. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Eva A K van Delft, Suus G J van Bruggen, Karlijn J van Stralen, Frank W Bloemers, Nico L Sosef, Niels W L Schep, Jefrey Vermeulen
There is no level I evidence dealing with the optimal period of immobilization for patients with a displaced distal radial fracture following closed reduction. A shorter period might lead to a better functional outcome due to less stiffness and pain. The aim of this study was to investigate whether this period could be safely reduced from six to four weeks.
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Delaying anterior cruciate ligament reconstruction increases the rate and severity of medial chondral injuries. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Nicolas Cance, Julien Erard, Jobe Shatrov, Gaspard Fournier, Stanislas Gunst, Guillaume L Martin, Sébastien Lustig, Elvire Servien
The aim of this study was to evaluate the association between chondral injury and interval from anterior cruciate ligament (ACL) tear to surgical reconstruction (ACLr).
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Standardization of global hip fracture audit could facilitate learning, improve quality, and guide evidence-based practice. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Antony Johansen, Andrew J Hall, Cristina Ojeda-Thies, Arwel T Poacher, Matthew L Costa
National hip fracture registries audit similar aspects of care but there is variation in the actual data collected; these differences restrict international comparison, benchmarking, and research. The Fragility Fracture Network (FFN) published a revised minimum common dataset (MCD) in 2022 to improve consistency and interoperability. Our aim was to assess compatibility of existing registries with the
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Robotic Arm-assisted versus Manual (ROAM) total knee arthroplasty: a randomized controlled trial. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Nick D Clement, Steven Galloway, Y Jenny Baron, Karen Smith, David J Weir, David J Deehan
The primary aim was to assess whether robotic total knee arthroplasty (rTKA) had a greater early knee-specific outcome when compared to manual TKA (mTKA). Secondary aims were to assess whether rTKA was associated with improved expectation fulfilment, health-related quality of life (HRQoL), and patient satisfaction when compared to mTKA.
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Birmingham Hip Resurfacing at 20 years. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Rohit Dhawan, David A Young, Anthony Van Eemeren, Andrew Shimmin
The Birmingham Hip Resurfacing (BHR) arthroplasty has been used as a surgical treatment of coxarthrosis since 1997. We present 20-year results of 234 consecutive BHRs performed in our unit.
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Anterosuperior versus deltopectoral approach for primary reverse total shoulder arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Arno A Macken, Arnela Haagmans-Suman, Anneke van Spekenbrink-Spooren, Arthur van Noort, Michel P J van den Bekerom, Denise Eygendaal, Geert A Buijze
The current evidence comparing the two most common approaches for reverse total shoulder arthroplasty (rTSA), the deltopectoral and anterosuperior approach, is limited. This study aims to compare the rate of loosening, instability, and implant survival between the two approaches for rTSA using data from the Dutch National Arthroplasty Registry with a minimum follow-up of five years.
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Time to return to work by occupational class after total hip or knee arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Tamara Kamp, Maaike G J Gademan, Sander K R van Zon, Rob G H H Nelissen, Thea P M Vliet Vlieland, Martin Stevens, Sandra Brouwer
For the increasing number of working-age patients undergoing total hip or total knee arthroplasty (THA/TKA), return to work (RTW) after surgery is crucial. We investigated the association between occupational class and time to RTW after THA or TKA.
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Cauda equina syndrome. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Ingrid Hoeritzauer, Mhairi Paterson, Aimun A B Jamjoom, Nisaharan Srikandarajah, Hamzah Soleiman, Michael T C Poon, Phillip C Copley, Catriona Graves, Sinead MacKay, Charis Duong, Andraay H C Leung, Niall Eames, Patrick F X Statham, Stacey Darwish, Philip J Sell, Paul Thorpe, Himanshu Shekhar, Holly Roy, Julie Woodfield
Patients with cauda equina syndrome (CES) require emergency imaging and surgical decompression. The severity and type of symptoms may influence the timing of imaging and surgery, and help predict the patient's prognosis. Categories of CES attempt to group patients for management and prognostication purposes. We aimed in this study to assess the inter-rater reliability of dividing patients with CES
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Annual incidence and assessment of risk factors for early-onset deep surgical site infection following primary total knee arthroplasty in osteoarthritis. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Jonathan Bourget-Murray, Sophie Piroozfar, Christopher Smith, Jennifer Ellison, Rohit Bansal, Rajrishi Sharma, Nathan Evaniew, Andrew Johnson, James N Powell
This study aims to determine difference in annual rate of early-onset (≤ 90 days) deep surgical site infection (SSI) following primary total knee arthroplasty (TKA) for osteoarthritis, and to identify risk factors that may be associated with infection.
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Patient-related risk factors associated with poorer outcomes following total ankle arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2023-09-01 Zaki Arshad, Ibrahim I Haq, Maneesh Bhatia
This scoping review aims to identify patient-related factors associated with a poorer outcome following total ankle arthroplasty (TAA).
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Does a Commercially Available Augmented Reality-based Portable Hip Navigation System Improve Cup Positioning During THA Compared With the Conventional Technique? A Randomized Controlled Study. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-31 Hiromasa Tanino, Ryo Mitsutake, Kenichi Takagi, Hiroshi Ito
Portable hip navigation systems have been developed to combine the accuracy of cup positioning by large console navigation systems with the ease of use and convenience of conventional surgical techniques. Although a novel augmented reality-based portable hip navigation system using a smartphone (AR navigation) has become available recently, no studies, to our knowledge, have compared commercially available
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Separating friend from foe; inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-29 Nathalie G.M. Thielen, Arjan P.M. van Caam, Henk M. v. Beuningen, Elly L. Vitters, Martijn H.J. van den Bosch, Marije I. Koenders, Fons A.J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan
Objective Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial to control cartilage homeostasis. However, TGF-β can also have detrimental effects by signaling via SMAD1/5/9 and thereby contribute to diseases like osteoarthritis (OA). In this study we aimed to block TGF-β-induced SMAD1/5/9 signaling in primary human OA chondrocytes, while maintaining functional SMAD2/3 signaling. Design
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Krüppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-28 Kemmei Ikuta, Shinya Hayashi, Kenichi Kikuchi, Masahiro Fujita, Kensuke Anjiki, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Tomoyuki Matsumoto, Tetsuya Hosooka, Wataru Ogawa, Ryosuke Kuroda
Objective Krüppel-like zinc finger transcription factors (KLFs) play diverse roles in mammalian cell differentiation and development. In this study, we investigated the function of KLF15 in the progression of osteoarthritis (OA). Methods Destabilization of the medial meniscus (DMM) surgery was performed in 10-week-old male wild-type control (WT) mice and cartilage-specific KLF15 knockout (KO) mice
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How Are Age, Gender, and Country Differences Associated With PROMIS Physical Function, Upper Extremity, and Pain Interference Scores? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-30 Constantin Yves Plessen, Gregor Liegl, Claudia Hartmann, Marilyn Heng, Alexander Joeris, Aaron J Kaat, Benjamin D Schalet, Felix Fischer, Matthias Rose
The interpretation of patient-reported outcomes requires appropriate comparison data. Currently, no patient-specific reference data exist for the Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF), Upper Extremity (UE), and Pain Interference (PI) scales for individuals 50 years and older.
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Characterization of adverse joint outcomes in patients with osteoarthritis treated with subcutaneous tanezumab Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-29 John A. Carrino, Timothy E McAlindon, Tom J. Schnitzer, Ali Guermazi, Marc C. Hochberg, Philip G. Conaghan, Mark T. Brown, Aimee Burr, Robert J. Fountaine, Glenn C. Pixton, Lars Viktrup, Kenneth M. Verburg, Christine West
Objective Due to the risk of rapidly progressive osteoarthritis (RPOA), the phase III studies of subcutaneous (SC) tanezumab in patients with moderate to severe hip or knee osteoarthritis (OA) included comprehensive joint safety surveillance. This pooled analysis summarizes these findings. Method Joint safety events in the phase III studies of SC tanezumab (2 placebo- and 1- nonsteroidal anti-inflammatory
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What Is the Likelihood of Union and Frequency of Complications After Parallel Plating and Supplemental Bone Grafting for Resistant Distal Femoral Nonunions? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-28 Ashok S Gavaskar, Naveen C Tummala, C Rajasekara Reddy, Hitesh Gopalan, Parthasarathy Srinivasan
Management of resistant distal femur nonunions is challenging because patients not only have disability from an unhealed fracture, but also often have a shortened femur, stiff knee, deformities, and bone defects to address during revision surgery. Dual plating of the distal femur in such a setting can maintain stability that allows the nonunion to heal while also addressing bone defects and correcting
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Does "Hoarding" Impact Interview Distribution Among Orthopaedic Surgery Residency Applicants? A Modeling Study Based on a Large Database. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-28 Catherine E Hutchison, Jason I Reminick, Ephy R Love, Suzanne Karan, Kenneth R Gundle
"Interview hoarding" is commonly used to refer to the concentration of interview offers among a small number of high-performing residency applicants. Theoretically, if the same applicants interview at every program, fewer rank lists will be submitted than open residency positions, leading to a "match crisis" with unfilled positions after the match. There are no published studies we are aware of that
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Do Orthopaedic Virtual Clinic Visits Demonstrate Cost and Time Efficiencies Compared With In-person Visits? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-25 Nicholas Livingston, Alex Lindahl, Jack McConnell, Ahmad Chouman, Charles S Day
There are numerous reasons for the increased use of telemedicine in orthopaedic surgery, one of which is the perception that virtual visits are more cost-effective than in-person visits. However, to our knowledge, no studies have compared the cost and time investment of virtual versus in-person visits using the time-driven activity-based costing (TDABC) method. Unlike methods that estimate cost based
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Immature bovine cartilage wear is due to fatigue failure from repetitive compressive forces and not reciprocating frictional forces Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-24 C.A. Petersen, C.V. Sise, J.X. Dewing, J. Yun, B.K. Zimmerman, X.E. Guo, C.T. Hung, G.A. Ateshian
Objective Wear of articular cartilage is not well understood. We hypothesize that cartilage wears due to fatigue failure in repetitive compression instead of reciprocating friction. Design This study compares reciprocating sliding of immature bovine articular cartilage against glass in two testing configurations: (1) a stationary contact area configuration (SCA), which results in static compression
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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5 Bone Res. (IF 12.7) Pub Date : 2023-08-24 Cassandra R. Diegel, Ina Kramer, Charles Moes, Gabrielle E. Foxa, Mitchell J. McDonald, Zachary B. Madaj, Sabine Guth, Jun Liu, Jennifer L. Harris, Michaela Kneissel, Bart O. Williams
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Strengthening the case for BMP inhibition as a point of intervention for osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-23 Karen M. Lyons, Vicki Rosen
Abstract not available
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Associations between weight change, knee subcutaneous fat and cartilage thickness in overweight and obese individuals: 4-Year data from the osteoarthritis initiative Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-22 Gabby B. Joseph, Melia Takakusagi, Gino Arcilla, John A. Lynch, Valentina Pedoia, Sharmila Majumdar, Nancy E. Lane, Michael C. Nevitt, Charles E. McCulloch, Thomas M. Link
Objective To assess (i) the impact of changes in body weight on changes in joint-adjacent subcutaneous fat (SCF) and cartilage thickness over 4 years and (ii) the relation between changes in joint-adjacent SCF and knee cartilage thickness. Design Individuals from the Osteoarthritis Initiative (total=399) with > 10% weight gain (n=100) and > 10% weight loss (n=100) over 4 years were compared to a matched
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Development and Validation of a Convolutional Neural Network Model to Predict a Pathologic Fracture in the Proximal Femur Using Abdomen and Pelvis CT Images of Patients With Advanced Cancer. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-23 Min Wook Joo, Taehoon Ko, Min Seob Kim, Yong-Suk Lee, Seung Han Shin, Yang-Guk Chung, Hong Kwon Lee
Improvement in survival in patients with advanced cancer is accompanied by an increased probability of bone metastasis and related pathologic fractures (especially in the proximal femur). The few systems proposed and used to diagnose impending fractures owing to metastasis and to ultimately prevent future fractures have practical limitations; thus, novel screening tools are essential. A CT scan of
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Osteoarthritis year in review 2023: metabolite and protein biomarkers Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-21 Ming Liu, Nafiza Haque, Jingyi Huang, Guangju Zhai
Objective To highlight the advances over the past year in metabolite/protein biomarkers for osteoarthritis (OA). Method A literature search of five databases including PubMed, Web of Science, Scopus, Ovid Medline, and Embase was performed for studies on metabolite/protein/peptide/biochemical markers for OA published between April 01, 2022 and March 31, 2023. Records were then screened to include only
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α-parvin controls chondrocyte column formation and regulates long bone development Bone Res. (IF 12.7) Pub Date : 2023-08-22 Jifan Yuan, Ling Guo, Jiaxin Wang, Zhongjun Zhou, Chuanyue Wu
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Intravenous Cefazolin Achieves Sustained High Interstitial Concentrations in Open Lower Extremity Fractures. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-22 Taylor J Bates, Matthew B Burgess, Gerardo R Garcia, Kevin S Akers, Lee C Mangum, Thomas B Lynch, Joseph C Wenke, Sarah N Pierrie
Infection remains a serious clinical concern in patients with open fractures, despite timely antibiotic administration and surgical debridement. Soft tissue and periosteal stripping may alter local tissue homeostasis and antibiotic pharmacokinetics in the injured limb. The tissue (interstitial) concentration of intravenously administered antibiotics at an open fracture site has not been characterized
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Whole Blood Metal Levels in the Setting of an Oncologic Endoprosthesis: Is There Cause for Concern? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-21 Matthew T Houdek, Cory G Couch, Cody C Wyles, Michael J Taunton, Peter S Rose, Hilal Maradit Kremers, David G Lewallen, Daniel J Berry
Massive modular endoprostheses have become a primary means of reconstruction after oncologic resection of a lower extremity tumor. These implants are commonly made with cobalt-chromium alloys that can undergo wear and corrosion, releasing cobalt and chromium ions into the surrounding tissue and blood. However, there are few studies about the blood metal levels in these patients.
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Mg-Zn-Ca Alloy (ZX00) Screws Are Resorbed at a Mean of 2.5 Years After Medial Malleolar Fracture Fixation: Follow-up of a First-in-humans Application and Insights From a Sheep Model. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-21 Viktor Labmayr, Omer Suljevic, Nicole Gabriele Sommer, Uwe Yacine Schwarze, Romy Linda Marek, Iva Brcic, Ines Foessl, Andreas Leithner, Franz Josef Seibert, Valentin Herber, Patrick Lukas Holweg
In the ongoing development of bioresorbable implants, there has been a particular focus on magnesium (Mg)-based alloys. Several Mg alloys have shown promising properties, including a lean, bioresorbable magnesium-zinc-calcium (Mg-Zn-Ca) alloy designated as ZX00. To our knowledge, this is the first clinically tested Mg-based alloy free from rare-earth elements or other elements. Its use in medial malleolar
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Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-19 Jinchi Tang, Michiel M.A. van Buuren, Noortje S. Riedstra, Fleur Boel, Jos. Runhaar, Sita. Bierma-Zeinstra, Rintje Agricola
Objective To determine the association between cam morphology and the development of radiographic hip osteoarthritis (RHOA) at four time points within 10-year follow-up. Design The nationwide prospective Cohort Hip and Cohort Knee (CHECK) study includes 1002 participants aged 45-65 years with 2-, 5-, 8-, and 10-year follow-ups. The associations of cam morphology (alpha angle >60°) and large cam morphology
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FACTORS ASSOCIATED WITH MENISCUS VOLUME IN KNEES FREE OF DEGENERATIVE FEATURES Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-19 Dawei Xu, Dieuwke Schiphof, Jukka Hirvasniemi, Stefan Klein, Edwin H.G. Oei, Sebastia Bierma-Zeinstra, Jos Runhaar
Objectives To explore factors that were associated with meniscus volume in knees free of radiographic OA features and symptoms of OA. Methods In the third Rotterdam Study cohort, clinical, radiographic, and MR data were obtained at baseline (BL) and after 5 years of follow-up. Meniscus volumes and their change over time were calculated after semi-automatic segmentation on MRI. Knees with radiographic
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Joint-adjacent subcutaneous adipose tissue — an obesity-related imaging biomarker associated with structural osteoarthritis progression? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-18 Wolfgang Wirth
Abstract not available
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Does Preoperative Pharmacogenomic Testing of Patients Undergoing TKA Improve Postoperative Pain? A Randomized Trial. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2023-08-18 Molly B Kraus, Joshua S Bingham, Adrijana Kekic, Colby Erickson, Christopher B Grilli, David P Seamans, David P Upjohn, Joseph G Hentz, Henry D Clarke, Mark J Spangehl
Pharmacogenomics is an emerging and affordable tool that may improve postoperative pain control. One challenge to successful pain control is the large interindividual variability among analgesics in their efficacy and adverse drug events. Whether preoperative pharmacogenomic testing is worthwhile for patients undergoing TKA is unclear.
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Is synovitis inevitable after ACL injury? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2023-08-17 Tristan Maerz
Abstract not available