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Periarticular vasoconstrictor infiltration: a novel technique for chemical vasoconstriction in major orthopaedic surgery Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-13 Vicente Roques Escolar, Pablo Oliver-Fornies, Mario Fajardo Perez
Abstract not available
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Quantitative sensory testing in paediatric patients with chronic pain: a systematic review and meta-analysis Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-13 Daniel E. Schoth, Markus Blankenburg, Julia Wager, Jin Zhang, Philippa Broadbent, Kanmani Radhakrishnan, Oda van Jole, Georgia L. Lyle, Helen Laycock, Boris Zernikow, Christina Liossi
Abstract not available
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Effects of remifentanil on brain responses to noxious stimuli during deep propofol sedation Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-13 Jesus Pujol, Gerard Martínez-Vilavella, Lluís Gallart, Laura Blanco-Hinojo, Susana Pacreu, Vincent Bonhomme, Joan Deus, Víctor Pérez-Sola, Pedro L. Gambús, Juan Fernández-Candil
Background The safety of anaesthesia has improved as a result of better control of anaesthetic depth. However, conventional monitoring does not inform on the nature of nociceptive processes during unconsciousness. A means of inferring the quality of potentially painful experiences could derive from analysis of brain activity using neuroimaging. We have evaluated the dose effects of remifentanil on
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Perioperative cardiovascular pathophysiology in patients undergoing lung resection surgery: a narrative review Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-13 Ben Shelley, Adam Glass, Thomas Keast, James McErlane, Cara Hughes, Brian Lafferty, Nandor Marczin, Philip McCall
Although thoracic surgery is understood to confer a high risk of postoperative respiratory complications, the substantial haemodynamic challenges posed are less well appreciated. This review highlights the influence of cardiovascular comorbidity on outcome, reviews the complex pathophysiological changes inherent in one-lung ventilation and lung resection, and examines their influence on cardiovascular
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Association between long-term opioid use and cancer risk in patients with chronic pain. Comment on Br J Anaesth 2022; 129: 84–91 Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-12 Wei-Min Chu, Paul S.-B. Huang, James C.-C. Wei
Abstract not available
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Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-11 Reena Ellis, Marianna Laviola, Daniel Stolady, Rebecca L. Valentine, Arani Pillai, Jonathan G. Hardman
Background Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to high-flow nasal oxygenation (HFNO), whilst allowing face-mask preoxygenation and rescue. Methods A high-fidelity, computational, physiological model was
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Augmented reality in paediatric oncology patients undergoing surgery: a feasibility randomised controlled trial Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-11 Juan P. Cata, German Corrales, Clinton Fuller, Jae E. Choi, Nicole M. Rosburg, Lei Feng, Jamie W. Sinton
Abstract not available
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Prevalence of pulmonary embolism and deep venous thrombosis during the COVID-19 pandemic in an intensive care unit cohort: a service evaluation Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-11 Nick Barnett, Donald Leith, Darsha Govind, Varsha Ramnani, Hannah Williamson, James Chung, Anya Drebes
Abstract not available
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Intensive care unit versus high dependency care unit admission after emergency surgery: a nationwide in-patient registry study Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-10 Hiroyuki Ohbe, Hiroki Matsui, Ryosuke Kumazawa, Hideo Yasunaga
Background The appropriate level of postoperative critical care for patients undergoing emergency surgery is unknown. We aimed to assess the outcomes of postoperative patients treated in the intensive care unit (ICU) and high dependency care unit (HDU) after emergency surgery. Methods Analysis of national in-patient registry data in Japan from July 2010 to March 2018, including patients undergoing
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Outcomes of dexmedetomidine versus propofol sedation in critically ill adults requiring mechanical ventilation: a systematic review and meta-analysis of randomised controlled trials Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-10 Kiyan Heybati, Fangwen Zhou, Saif Ali, Jiawen Deng, Divyanshu Mohananey, Pedro Villablanca, Harish Ramakrishna
Background Guidelines have recommended the use of dexmedetomidine or propofol for sedation after cardiac surgery, and propofol monotherapy for other patients. Further outcome data are required for these drugs. Methods This systematic review and meta-analysis was prospectively registered on PROSPERO. The primary outcome was ICU length of stay. Secondary outcomes included duration of mechanical ventilation
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A thirst for progress Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-06 Rebecca Sands, Robert Wiltshire, Peter Isherwood
Abstract not available
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Interventions for the prevention or treatment of epidural-related maternal fever: a systematic review and meta-analysis Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-05 Anna Cartledge, Daniel Hind, Mike Bradburn, Marrissa Martyn-St James, Sophie Davenport, Wei Shao Tung, Hwu Yung, Jeyinn Wong, Matthew Wilson
Background Epidural-related maternal fever has consequences for the mother and neonate. There has been no systematic review of preventive strategies. Methods RCTs evaluating methods of preventing or treating epidural-related maternal fever in women in active labour were eligible. We searched MEDLINE, EMBASE, CINAHL, Web of Science, CENTRAL, and grey literature sources were searched from inception to
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Screening validity of quantitative infrared pupillometry for predicting neurological outcomes in patients admitted to intensive care. Response to Br J Anaesth 2022 Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-04 Alex Warren, Alastair Proudfoot
Abstract not available
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Effect of acute pain on the association between preoperative cognitive impairment and postoperative delirium: a secondary analysis of three trials Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-03 Jia-Hui Ma, Ya-Fei Liu, Hong Hong, Chun-Jing Li, Fan Cui, Dong-Liang Mu, Dong-Xin Wang
Background The association between preoperative cognitive impairment, postoperative pain, and postoperative delirium in older patients after noncardiac surgery is not known. Methods This was a secondary analysis of datasets from three previous studies. Patients aged ≥55 yr who underwent elective noncardiac surgery were enrolled. Preoperative cognitive impairment was defined as Mini-Mental State Examination
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Wearable transcutaneous electrical acupoint stimulation bracelet for prevention of postoperative nausea and vomiting in patients undergoing hysteroscopic surgery: a randomised controlled trial Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-03 Na Wang, Peng Ding, Dong-Yu Zheng, Jun Pu, Li-Ye Yang, Yang-Yang Zhou, Dong-Jie Li, Wei Chen, Yong-Hua Li
Abstract not available
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Tracheostomy outcomes in critically ill COVID-19 patients: a systematic review, meta-analysis, and meta-regression Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-03 Denise Battaglini, Lavienraj Premraj, Nicole White, Anna-Liisa Sutt, Chiara Robba, Sung-Min Cho, Ida Di Giacinto, Filippo Bressan, Massimiliano Sorbello, Brian Cuthbertson, Gianluigi Li Bassi, Jacky Suen, John Fraser, Paolo Pelosi
Introduction We performed a systematic review in COVID-19 mechanically ventilated (MV) patients which analysed the effect of tracheostomy timing and technique (surgical vs. percutaneous) on mortality. Secondary outcomes included intensive care unit (ICU)-and hospital-length-of-stay (LOS), decannulation from tracheostomy, duration of MV, and complications. Methods Four databases were screened between
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Translating evidence into practice: still a way to go Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-02 David R. McIlroy
Chiu and colleagues report a retrospective analysis describing the 5-yr trend in both intraoperative fluid and vasopressor administration in 32 250 patients undergoing elective abdominal surgery within the Multicenter Perioperative Outcomes Group (MPOG) database from 2015 to 2019, and exploring the association between these two factors and acute kidney injury. Modelling predicted the lowest risk for
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Screening validity of quantitative infrared pupillometry for predicting neurological outcomes in patients admitted to intensive care. Comment on Br J Anaesth 2022; 128: 849–56 Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-02 Tomoyuki Kawada
Abstract not available
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When will we call time on desflurane? Comment on Br J Anaesth 2022 Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-02 Peter Brooks, Anthony R. Absalom
Abstract not available
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Parallels between our response to COVID-19 and patient safety Br. J. Anaesth. (IF 11.719) Pub Date : 2022-08-01 Jonathan B. Cohen, Sephalie Y. Patel
The response to the COVID-19 pandemic and the approach to patient safety share three important concepts: the challenges of preventing rare events, use of rules, and tolerance for uncertainty. We discuss how each of these ideas can be utilised in perioperative safety to create a high reliability system.
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Trials with ‘non-significant’ results are not insignificant trials: a common significance threshold distorts reporting and interpretation of trial results Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-22 Emily A. Vail, Michael S. Avidan
We discuss a newly published study examining how phrases are used in clinical trials to describe results when the estimated P-value is close to (slightly above or slightly below) 0.05, which has been arbitrarily designated by convention as the boundary for ‘statistical significance’. Terms such as ‘marginally significant’, ‘trending towards significant’, and ‘nominally significant’ are well represented
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How to survive the thyroid storm: what we can learn from case reports Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-21 Nikki de Mul, Rogier V. Immink
Abstract not available
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End the confusion: general anaesthesia improves patient outcomes in endovascular thrombectomy Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-20 Doug Campbell, Elise Butler, P.Alan Barber
Expert physiological and pharmacological care by anaesthetists is required in all stroke endovascular thrombectomy cases. RCTs show clinical benefits in recanalisation rates and functional recovery after endovascular thrombectomy with general anaesthesia compared with sedation. Many stroke centres will require wholesale reorganisation of stroke pathways to ensure anaesthesia services are available
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Linking and unlinking the paediatric brain: age-invariant neural correlates of general anaesthesia Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-19 Michael P. Puglia, George A. Mashour
There is no single electroencephalographic metric for general anaesthesia that is validated for both children and adults. This is, in part, because of the changing electroencephalographic features associated with development. Here, we discuss how alterations in correlated brain activity during general anaesthesia advance our understanding of anaesthetic monitoring and the neurobiology of consciousness
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Impact of enhanced personal protective equipment on safety and logistics of pre-hospital emergency anaesthesia during the COVID-19 pandemic: a retrospective crossover study Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-19 J. Dawson, J. Humphrey, J. Samouelle, P.B. Sherren
Abstract not available
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The drug titration paradox: more drug does not correlate with more effect in individual clinical data Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-19 Thomas W. Schnider, Charles F. Minto, Martin Luginbühl, Talmage D. Egan
Background A fundamental concept in pharmacology is that increasing dose increases drug effect. This is the basis of anaesthetic titration: the dose is increased when increased drug effect is desired and decreased when reduced drug effect is desired. In the setting of titration, the correlation of doses and observed drug effects can be negative, for example increasing dose reduces drug effect. We have
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Live, die, repeat: a simulation-based education perspective. Comment on Br J Anaesth 2022; 129: e12–e13 Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-16 Matthew J. Aldridge, Jeremy Purdell-Lewis
Abstract not available
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Postoperative anaemia and patient-centred outcomes after major abdominal surgery: a retrospective cohort study. Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-15 Paul S Myles,Toby Richards,Andrew Klein,Erica M Wood,Sophie Wallace,Mark A Shulman,Catherine Martin,Rinaldo Bellomo,Tomás B Corcoran,Philip J Peyton,David A Story,Kate Leslie,Andrew Forbes,
BACKGROUND Compared with anaemia before surgery, the underlying pathogenesis and implications of postoperative anaemia are largely unknown. METHODS This retrospective cohort study analysed prospective data obtained from 2983 adult patients across 47 centres enrolled in a clinical trial evaluating restrictive and liberal intravenous fluids. The primary endpoint was persistent disability or death up
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Passive leg raising-induced changes in pulse pressure variation to assess fluid responsiveness in mechanically ventilated patients: a multicentre prospective observational study Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-14 Jihad Mallat, Marc-Olivier Fischer, Maxime Granier, Christophe Vinsonneau, Marie Jonard, Yazine Mahjoub, Fawzi Ali Baghdadi, Sébastien Préau, Fabien Poher, Olivier Rebet, Belaid Bouhemad, Malcolm Lemyze, Mehdi Marzouk, Emmanuel Besnier, Fadi Hamed, Nadeem Rahman, Osama Abou-Arab, Pierre-Grégoire Guinot
Background Passive leg raising-induced changes in cardiac index can be used to predict fluid responsiveness. We investigated whether passive leg raising-induced changes in pulse pressure variation (ΔPPVPLR) can also predict fluid responsiveness in mechanically ventilated patients. Methods In this multicentre prospective observational study, we included 270 critically ill patients on mechanical ventilation
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Perioperative cerebrospinal fluid sorbitol and fructose concentrations in patients undergoing thoracic aortic surgery. Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-14 Mark L van Zuylen,Annemieke M Peters van Ton,Harmke B Duindam,Erik Scholten,Eric P A van Dongen,Werner Ten Hoope,Mark P Plummer,J Hans DeVries,Benedikt Preckel,Gert-Jan Scheffer,Wilson F Abdo,Jeroen Hermanides
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No place for routine use of modified-release opioids in postoperative pain management. Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-14 Jane Quinlan,Nicholas Levy,Dileep N Lobo,Pamela E Macintyre
Modified-release opioid tablets were introduced into surgical practice in the belief that they provided superior pain relief and reduced nursing workload, and they rapidly became embedded into many perioperative pathways. Although national and international guidelines for the management of postoperative pain now advise against the use of modified-release opioids, they continue to be prescribed in many
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Feasibility and outcomes of a real-world regional lung cancer prehabilitation programme in the UK Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-13 Patrick Bradley, Zoe Merchant, Kirsty Rowlinson-Groves, Marcus Taylor, John Moore, Matthew Evison
Background Prehabilitation, or multimodality patient optimisation before major treatment, has demonstrated meaningful improvements in patients' outcomes. In the setting of lung cancer surgery, postoperative complications and length of hospital stay are reduced, but there is currently limited access to prehabilitation. Prehab4Cancer (P4C) is an innovative regional programme serving all areas of Greater
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On the horns of a dilemma: choosing total intravenous anaesthesia or volatile anaesthesia Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-11 Bernhard Riedel, Julia Dubowitz, Joyce Yeung, Shaman Jhanji, Sachin Kheterpal, Michael S. Avidan
There are two established techniques of delivering general anaesthesia: propofol-based total intravenous anaesthesia (TIVA) and volatile agent-based inhaled anaesthesia. Both techniques are offered as standard of care and have an established safety track record lasting more than 30 years. However, it is not currently known whether the choice of anaesthetic technique results in a fundamentally different
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Towards better predictive models of chronic post-surgical pain: fitting to the dynamic nature of the pain itself Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-11 Dominique Fletcher, Patricia Lavand'homme
Chronic post-surgical pain predictive scores exist, but none has yet demonstrated an impact on patient care. Van Driel and colleagues offer an additional perspective on early postoperative detection of patient at risk of chronic post-surgical pain to enable early interventions in prevention and treatment. The authors derived and validated a model based on four easily obtainable predictors that could
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Regional and neuraxial anaesthesia techniques for spinal surgery: a scoping review Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-09 Aisling Ní Eochagáin, Barry N. Singleton, Aneurin Moorthy, Donal J. Buggy
Background Whilst general anaesthesia is commonly used to undertake spine surgery, the use of neuraxial and peripheral regional anaesthesia techniques for intraoperative and postoperative analgesia is an evolving practice. Variations in practice have meant that it is difficult to know which modalities achieve optimal outcomes for patients undergoing spinal surgery. Our objective was to identify available
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Comparative benefits and harms of individual opioids for chronic non-cancer pain: a systematic review and network meta-analysis of randomised trials Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-09 Atefeh Noori, Behnam Sadeghirad, Li Wang, Reed A.C. Siemieniuk, Mostafa Shokoohi, Elena Kum, Mark Jeddi, Luis Montoya, Patrick J. Hong, Edward Zhou, Rachel J. Couban, David N. Juurlink, Lehana Thabane, Mohit Bhandari, Gordon H. Guyatt, Jason W. Busse
Background Most systematic reviews of opioids for chronic pain have pooled treatment effects across individual opioids under the assumption they provide similar benefits and harms. We examined the comparative effects of individual opioids for chronic non-cancer pain through a network meta-analysis of randomised controlled trials. Methods We searched MEDLINE, EMBASE, CINAHL, and the Cochrane Central
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Ultrasound transducer with dynamic visual aid improves out-of-plane vascular access: a feasibility study Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-09 Harm J. Scholten, Yomi Hoever, Elke Kanters, Tamara Hoveling, Marco de Wild, Erik H.M. Korsten, R. Arthur Bouwman
Abstract not available
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Videolaryngoscopy versus direct laryngoscopy for adults undergoing tracheal intubation: a Cochrane systematic review and meta-analysis update Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-09 Jan Hansel, Andrew M. Rogers, Sharon R. Lewis, Tim M. Cook, Andrew F. Smith
Background Tracheal intubation is a commonly performed procedure that can be associated with complications and result in patient harm. Videolaryngoscopy (VL) may decrease this risk as compared with Macintosh direct laryngoscopy (DL). This review evaluates the risk and benefit profile of VL compared with DL in adults. Methods We searched MEDLINE, Embase, CENTRAL, and Web of Science on February 27, 2021
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Videolaryngoscopy as a first-intention technique for tracheal intubation in unselected surgical patients: a before and after observational study Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-08 Audrey De Jong, Thomas Sfara, Yvan Pouzeratte, Joris Pensier, Amélie Rolle, Gérald Chanques, Samir Jaber
Background Using a Macintosh-style videolaryngoscope as a first-intention device for intubating unselected patients in the operating room has not often been studied. We hypothesised that using a Macintosh-style videolaryngoscope as a first-intention device would be associated with an increased proportion of easy tracheal intubation. Methods In a quality improvement project for airway management aimed
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A novel anterior approach for ultrasound-guided lumbar plexus combined with sacral plexus blocks with one-point puncture. Comment on Br J Anaesth 2022; 128: 297-299 Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-08 Ghansham Biyani, Sadik Mohammed
Abstract not available
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Comparison of continuous with single-injection regional analgesia on patient experience after ambulatory orthopaedic surgery: A randomised multicentre trial Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-07 Axel Maurice-Szamburski, Philippe Grillo, Philippe Cuvillon, Thierry Gazeau, Laurent Delaunay, Pascal Auquier, Sophie Bringuier, Xavier Capdevila
Background The optimal approach to improving patient experience and analgesia after ambulatory orthopaedic surgery remains unclear. Methods This multicentre, randomised clinical trial compared single-injection nerve block analgesia with home delivery of continuous nerve block analgesia by remote-controlled electronic pump. The primary outcome was patient-reported satisfaction (Evaluation du Vecu de
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Perioperative risk factors associated with increased incidence of postoperative delirium: systematic review, meta-analysis, and Grading of Recommendations Assessment, Development, and Evaluation system report of clinical literature Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-07 Lior Mevorach, Ali Forookhi, Alessio Farcomeni, Stefano Romagnoli, Federico Bilotta
Background Systematic reviews to date have neglected to exclusively include studies using a validated diagnostic scale for postoperative delirium and monitoring patients for more than 24 h. Evidence on current risk factors is evolving with significantly heterogeneous study designs, inconsistent reporting of results, and a lack of adjustment for bias. Methods This systematic review and meta-analysis
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Lifestyle and chronic pain: double jeopardy? Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-06 Anne-Priscille Trouvin, Nadine Attal, Serge Perrot
Given the often disappointing results of pharmacotherapy, many patients with chronic pain seek to modify their lifestyle. Some lifestyle factors, such as the consumption of alcohol, tobacco, cannabis, or psychostimulants, are deleterious in this context, whereas others, such as physical activity and a balanced diet, are considered beneficial, but these require substantial effort on the part of patients
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Current approaches to acute postoperative pain management after major abdominal surgery: a narrative review and future directions Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-06 Katrina Pirie, Emily Traer, Damien Finniss, Paul S. Myles, Bernhard Riedel
Poorly controlled postoperative pain is associated with increased morbidity, negatively affects quality of life and functional recovery, and is a risk factor for persistent pain and longer-term opioid use. Up to 10% of opioid-naïve patients have persistent opioid use after many types of surgeries. Opioid-related side-effects and the opioid abuse epidemic emphasise the need for alternative, opioid-minimising
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Ultrasound-guided erector spinae plane block improves analgesia after laparoscopic hepatectomy: a randomised controlled trial Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-06 Xin Huang, Jiao Wang, Juntao Zhang, Yi Kang, Bhushan Sandeep, Jing Yang
Background Laparoscopic hepatectomy is associated with trauma and severe pain. We examined whether bilateral, ultrasound-guided, single-injection erector spinae plane block (ESPB) could improve on postoperative analgesia compared with patient-controlled intravenous analgesia in patients undergoing laparoscopic hepatectomy. Methods Fifty adults were randomly allocated to receive patient-controlled intravenous
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Emerging functional connectivity patterns during sevoflurane anaesthesia in the developing human brain Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-06 Adela Desowska, Charles B. Berde, Laura Cornelissen
Background Spectral-based EEG is used to monitor anaesthetic state during surgical procedures in adults. Spectral EEG features that can resemble the patterns seen in adults emerge in children after the age of 10 months and cannot distinguish wakefulness and anaesthesia in the youngest children. There is a need to explore alternative EEG measures. We hypothesise that functional connectivity is one of
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Dexamethasone and clinically significant postoperative nausea and vomiting: a prespecified substudy of the randomised perioperative administration of dexamethasone and infection (PADDI) trial Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-06 Tomás B. Corcoran, Catherine Martin, Edmond O'Loughlin, Kwok M. Ho, Pauline Coutts, Matthew T. Chan, Andrew Forbes, Kate Leslie, Paul Myles
Background Clinically significant postoperative nausea and vomiting (PONV) is a patient-reported outcome which reflects patient experience. Although dexamethasone prevents PONV, it is unknown what impact it has on this experience. Methods In this prespecified embedded superiority substudy of the randomised Perioperative Administration of Dexamethasone and Infection (PADDI) trial, patients undergoing
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Monkeypox and its pandemic potential: what the anaesthetist should know Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-06 Sumit R. Chowdhury, Priyankar K. Datta, Souvik Maitra
Abstract not available
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Corrigendum to ‘Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology’ (Br J Anaesth 2020; 124: e29-e33) Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-06 Siri Leknes, Lauren Y. Atlas
Abstract not available
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Sevoflurane enhances brain glycolysis and lactate production in aged marmosets Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-02 Lei Zhang, Haoli Mao, Jia Yan, Yanyong Cheng, Zhenyu Xue, Zilong Qiu, Hong Jiang
Abstract not available
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Effect of race on opioid drug overdose deaths in the United States: an observational cross-sectional study Br. J. Anaesth. (IF 11.719) Pub Date : 2022-07-02 Austin D. Le, Yuemeng Li, Alicia Zhu, Jaiveer Singh, Jane Y. Xu, Malathi Srinivasan, Latha P. Palaniappan, Jin Long, Eric R. Gross
Abstract not available
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How tired is your anaesthetist? Use of a fatigue risk prediction tool in medical roster analysis Br. J. Anaesth. (IF 11.719) Pub Date : 2022-06-29 Matthew Roche, Rachel Tresman, Daniel Puntis, Alex Hunter, Luke Hodgson
Abstract not available
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Gender representation on editorial boards of anaesthesiology journals from 2010 to 2020 Br. J. Anaesth. (IF 11.719) Pub Date : 2022-06-29 Sabrina Pan, William Zheng, Lisa Q. Rong
Abstract not available
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Protective effects of omega-3 fatty acids in a blood–brain barrier-on-chip model and on postoperative delirium-like behaviour in mice Br. J. Anaesth. (IF 11.719) Pub Date : 2022-06-29 Ting Yang, Ravikanth Velagapudi, Cuicui Kong, Unghyeon Ko, Vardhman Kumar, Paris Brown, Nathan O. Franklin, Xiaobei Zhang, Ana I. Caceres, Hyunjung Min, Anthony J. Filiano, Ramona M. Rodriguiz, William C. Wetsel, Shyni Varghese, Niccolò Terrando
Background Peripheral surgical trauma can trigger neuroinflammation and ensuing neurological complications, such as delirium. The mechanisms whereby surgery contributes to postoperative neuroinflammation remain unclear and without effective therapies. Here, we developed a microfluidic-assisted blood–brain barrier (BBB) device and tested the effects of omega-3 fatty acids on neuroimmune interactions
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Epidemiology of persistent postoperative opioid use after cardiac surgery: a systematic review and meta-analysis Br. J. Anaesth. (IF 11.719) Pub Date : 2022-06-29 Zhengyang Liu, Alexandra D. Karamesinis, Mark Plummer, Reny Segal, Rinaldo Bellomo, Julian A. Smith, Luke A. Perry
Background The epidemiology of persistent postoperative opioid use at least 3 months after cardiac surgery is poorly characterised despite its potential public health importance. Methods We searched MEDLINE, Embase, and Google Scholar from inception to December 2021 and included studies reporting the rate and risk factors of persistent postoperative opioid use after cardiac surgery in opioid-naive
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Impact of cardiopulmonary bypass duration on efficacy of fibrinogen replacement with cryoprecipitate compared with fibrinogen concentrate: a post hoc analysis of the Fibrinogen Replenishment in Surgery (FIBRES) randomised controlled trial Br. J. Anaesth. (IF 11.719) Pub Date : 2022-06-28 Justyna Bartoszko, Selene Martinez-Perez, Jeannie Callum, Keyvan Karkouti
Background Coagulopathy in cardiac surgery is frequently associated with acquired hypofibrinogenaemia, which can be treated with either purified fibrinogen concentrate (FC) or cryoprecipitate. Because the latter is not purified and therefore contains additional coagulation factors, it is thought to be more effective for treatment of coagulopathy that occurs after prolonged cardiopulmonary bypass (CPB)
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Combined proximal or distal nerve blocks for postoperative analgesia after total knee arthroplasty: a randomised controlled trial Br. J. Anaesth. (IF 11.719) Pub Date : 2022-06-28 Philippe Marty, Clément Chassery, Olivier Rontes, Corine Vuillaume, Bertrand Basset, Mehdi Merouani, Constance Marquis, Anne De Lussy, Fabrice Ferré, Cécile Naudin, Girish P. Joshi, Alain Delbos
Background Many regional anaesthetic techniques have been proposed to manage pain after total knee arthroplasty, but the best approach is unclear. We compared opioid consumption in the first 48 h between two different regional anaesthesia strategies in patients undergoing total knee arthroplasty. Methods In this single-centre, prospective study, we randomly allocated 90 patients to a combination of