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End-to-end donor screening and manufacturing controls: complementary quality-based strategies to minimize patient risk for donor-derived microbiome therapeutics. Gut Microbes (IF 12.2) Pub Date : 2024-09-18 Jason Goldsmith,Sarah Tomkovich,John G Auniņš,Barbara H McGovern,Jennifer C Mahoney,Brooke R Hasson,Christopher W J McChalicher,David S Ege
Advances in microbiome therapeutics have been motivated by a deeper understanding of the role that the gastrointestinal microbiome plays in human health and disease. The FDA approval of two stool-derived live biotherapeutic products (LBPs), REBYOTA® 150 mL enema (fecal microbiota, live-jslm; formerly RBX2660) and VOWST® oral capsules (fecal microbiota spores, live-brpk; formerly SER-109), for the prevention
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Molecular serotyping of diarrheagenic Escherichia coli with a MeltArray assay reveals distinct correlation between serotype and pathotype. Gut Microbes (IF 12.2) Pub Date : 2024-09-18 Chen Du,Yiqun Liao,Congcong Ding,Jiayu Huang,Shujuan Zhou,Yiyan Xu,Zhaohui Yang,Xiaolu Shi,Yinghui Li,Min Jiang,Le Zuo,Minxu Li,Shengzhe Bian,Na Xiao,Liqiang Li,Ye Xu,Qinghua Hu,Qingge Li
Diarrheagenic Escherichia coli serotypes are associated with various clinical syndromes, yet the precise correlation between serotype and pathotype remains unclear. A major barrier to such studies is the reliance on antisera-based serotyping, which is culture-dependent, low-throughput, and cost-ineffective. We have established a highly multiplex PCR-based serotyping assay, termed the MeltArray E. coli
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Gut microbiota-derived butyrate selectively interferes with growth of carbapenem-resistant Escherichia coli based on their resistance mechanism. Gut Microbes (IF 12.2) Pub Date : 2024-09-18 Eva Happ,Kora Schulze,Zinia Afrin,Sabrina Woltemate,Pia Görner,Stefan Ziesing,Dirk Schlüter,Robert Geffers,Volker Winstel,Marius Vital
We investigated consequences of resistance acquisition in Escherichia coli clinical isolates during anaerobic (continuous culture) growth and examined their sensitivity to butyrate, a hallmark metabolite of healthy gut microbiota. Strains were stratified based on carrying either a carbapenemase (CARB) or displaying porin malfunctioning (POR). POR displayed markedly altered growth efficiencies, lower
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ADP-heptose attenuates Helicobacter pylori-induced dendritic cell activation. Gut Microbes (IF 12.2) Pub Date : 2024-09-17 Theresa Neuper,Tobias Frauenlob,Hieu-Hoa Dang,Peter W Krenn,Gernot Posselt,Christof Regl,Nikolaus Fortelny,Veronika Schäpertöns,Michael S Unger,Gunda Üblagger,Daniel Neureiter,Iris Mühlbacher,Michael Weitzendorfer,Franz Singhartinger,Klaus Emmanuel,Christian G Huber,Silja Wessler,Fritz Aberger,Jutta Horejs-Hoeck
Sophisticated immune evasion strategies enable Helicobacter pylori (H. pylori) to colonize the gastric mucosa of approximately half of the world's population. Persistent infection and the resulting chronic inflammation are a major cause of gastric cancer. To understand the intricate interplay between H. pylori and host immunity, spatial profiling was used to monitor immune cells in H. pylori infected
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Empowering probiotics with high xanthine transport for effective hyperuricemia management. Gut Microbes (IF 12.2) Pub Date : 2024-09-17 Zhen-Ping Zou,Ju-Ling Li,Yi-Fan Zhang,Ying Zhou,Bang-Ce Ye
Hyperuricemia, a prevalent metabolic disorder, poses a susceptibility to various complications. The conventional pharmacotherapeutic approaches for hyperuricemia often entail notable adverse effects, posing substantial clinical challenges. Hence, the imperative lies in the development of novel, safe and effective strategies for preventing and treating hyperuricemia. Here, we developed a probiotic Escherichia
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Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids. Gut Microbes (IF 12.2) Pub Date : 2024-09-17 Ning Li,Xinyan Han,Ming Ruan,Fei Huang,Liu Yang,Tianhao Xu,Huijun Wang,Hui Wu,Songshan Shi,Yongjun Wang,Xiaojun Wu,Shunchun Wang
Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination occurring in the central nervous system (CNS). Inulin is a common prebiotic that can improve metabolic disorders by modulating the gut microbiota. However, its capacity to affect CNS autoimmunity is poorly recognized. Experimental autoimmune encephalomyelitis (EAE) is a classical mouse model of MS. Herein,
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Gut microbe-host interactions in post-COVID syndrome: a debilitating or restorative partnership? Gut Microbes (IF 12.2) Pub Date : 2024-09-17 Torsten P M Scheithauer,Roy C Montijn,Arnout Mieremet
Post-COVID syndrome (PCS) patients have reported a wide range of symptoms, including fatigue, shortness of breath, and diarrhea. Particularly, the presence of gastrointestinal symptoms has led to the hypothesis that the gut microbiome is involved in the development and severity of PCS. The objective of this review is to provide an overview of the role of the gut microbiome in PCS by describing the
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Effect of diet on the gut mycobiome and potential implications in inflammatory bowel disease. Gut Microbes (IF 12.2) Pub Date : 2024-09-17 J Buttar,E Kon,A Lee,G Kaur,G Lunken
The gut microbiome is a complex, unique entity implicated in the prevention, pathogenesis, and progression of common gastrointestinal diseases. While largely dominated by bacterial populations, advanced sequencing techniques have identified co-inhabiting fungal communities, collectively referred to as the mycobiome. Early studies identified that gut inflammation is associated with altered microbial
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Enterotoxigenic Escherichia coli heat labile enterotoxin affects neutrophil effector functions via cAMP/PKA/ERK signaling. Gut Microbes (IF 12.2) Pub Date : 2024-09-16 Jinglin Ma,Leen Hermans,Matthias Dierick,Hans Van der Weken,Eric Cox,Bert Devriendt
Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in humans and animals, induced by enterotoxins produced by these pathogens. Despite the crucial role of neutrophils in combatting bacterial infections, our understanding of how enterotoxins impact neutrophil function is limited. To address this knowledge gap, we used heat-labile enterotoxin (LT) and heat-stable enterotoxin
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The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease. Gut Microbes (IF 12.2) Pub Date : 2024-09-16 Kallie E Hays,Jacob M Pfaffinger,Rebecca Ryznar
Short-chain fatty acids (SCFAs) - acetate, propionate, and butyrate - are important bacterial fermentation metabolites regulating many important aspects of human physiology. Decreases in the concentrations of any or multiple SCFAs are associated with various detrimental effects to the host. Previous research has broadly focused on gut microbiome produced SCFAs as a group, with minimal distinction between
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Gut microbiota mediate early life stress-induced social dysfunction and anxiety-like behaviors by impairing amino acid transport at the gut Gut Microbes (IF 12.2) Pub Date : 2024-09-11 Jiushuang Zhu, Zhuoting Zhong, Lijie Shi, Ling Huang, Chunqiao Lin, Yan He, Xiuwen Xia, Tiane Zhang, Weijun Ding, Youjun Yang
Early life stress alters gut microbiota and increases the risk of neuropsychiatric disorders, including social deficits and anxiety, in the host. However, the role of gut commensal bacteria in earl...
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Gut microbiota-mediated C-sulfonate metabolism impairs the bioavailability and anti-cholestatic efficacy of andrographolide. Gut Microbes (IF 12.2) Pub Date : 2024-09-12 Dafu Tang,Wanyu Hu,Bingxuan Fu,Xiaojie Zhao,Guoquan You,Cong Xie,Hong Yu Wang,Xueni Guo,Qianbing Zhang,Zhongqiu Liu,Ling Ye
Cholestatic liver injury results from the accumulation of toxic bile acids in the liver, presenting a therapeutic challenge with no effective treatment available to date. Andrographolide (AP) has exhibited potential as a treatment for cholestatic liver disease. However, its limited oral bioavailability poses a significant obstacle to harnessing its potent therapeutic properties and restricts its clinical
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Fecal microbiota transplantation derived from mild cognitive impairment individuals impairs cerebral glucose uptake and cognitive function in wild-type mice: Bacteroidetes and TXNIP-GLUT signaling pathway. Gut Microbes (IF 12.2) Pub Date : 2024-09-12 Tao Wang,Ling Hao,Kexin Yang,Wenjing Feng,Zhiting Guo,Miao Liu,Rong Xiao
Gut microbiome dysbiosis has been widely implicated in cognitive impairment, but the identity of the specific bacterial taxa and mechanisms are not fully elucidated. Brain glucose hypometabolism coincides with the cognitive decline. This study explored the link among cognition, gut microbiota and glucose uptake based on the fecal microbiota transplantation from mild cognitive impairment individuals
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The hidden base of the iceberg: gut peptidoglycome dynamics is foundational to its influence on the host Gut Microbes (IF 12.2) Pub Date : 2024-09-06 Richard Wheeler, Ivo Gomperts Boneca
The intestinal microbiota of humans includes a highly diverse range of bacterial species. All these bacteria possess a cell wall, composed primarily of the macromolecule peptidoglycan. As such, the...
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Microbiome 2.0: lessons from the 2024 Gut Microbiota for Health World Summit Gut Microbes (IF 12.2) Pub Date : 2024-09-10 Sushrut Jangi, Gail Hecht
This Meeting Summary highlights the key insights from the 12th meeting of the Gut Microbiota for Health World Summit, held in Washington, DC, organized by the American Gastroenterological Associati...
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Segmental patterning of microbiota and immune cells in the murine intestinal tract. Gut Microbes (IF 12.2) Pub Date : 2024-09-10 Harithaa Anandakumar,Ariana Rauch,Moritz I Wimmer,Alex Yarritu,Gudrun Koch,Victoria McParland,Hendrik Bartolomaeus,Nicola Wilck
The intestine exhibits distinct characteristics along its length, with a substantial immune cell reservoir and diverse microbiota crucial for maintaining health. This study investigates how anatomical location and regional microbiota influence intestinal immune cell abundance. Using conventionally colonized and germ-free mice, segment-specific immune cell composition and microbial communities were
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Inflammation promotes stomach epithelial defense by stimulating the secretion of antimicrobial peptides in the mucus. Gut Microbes (IF 12.2) Pub Date : 2024-09-08 Megi Vllahu,Antonia Voli,Valerio Licursi,Claudia Zagami,Antonella D'Amore,Jan Traulsen,Sara Woelffling,Monika Schmid,Robbie Crickley,Richard Lisle,Alexander Link,Alessandra Tosco,Thomas F Meyer,Francesco Boccellato
The mucus serves as a protective barrier in the gastrointestinal tract against microbial attacks. While its role extends beyond merely being a physical barrier, the extent of its active bactericidal properties remains unclear, and the mechanisms regulating these properties are not yet understood. We propose that inflammation induces epithelial cells to secrete antimicrobial peptides, transforming mucus
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Protection against fibrosis by a bacterial consortium in metabolic dysfunction-associated steatohepatitis and the role of amino acid metabolism Gut Microbes (IF 12.2) Pub Date : 2024-09-06 Suet-Ying Kwan, Kristyn A. Gonzales, Mohamed A. Jamal, Heather L. Stevenson, Lin Tan, Philip L. Lorenzi, P. Andrew Futreal, Ernest T. Hawk, Joseph B. McCormick, Susan P. Fisher-Hoch, Robert R. Jenq, Laura Beretta
The gut microbiota drives progression to liver fibrosis, the main determinant of mortality in metabolic dysfunction-associated steatohepatitis (MASH). In this study, we aimed to identify bacterial ...
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Bile acids impact the microbiota, host, and C. difficile dynamics providing insight into mechanisms of efficacy of FMTs and microbiota-focused therapeutics Gut Microbes (IF 12.2) Pub Date : 2024-09-03 Arthur S. McMillan, Casey M. Theriot
Clostridioides difficile is a major nosocomial pathogen, causing significant morbidity and mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection (CDI), d...
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MRGM: an enhanced catalog of mouse gut microbial genomes substantially broadening taxonomic and functional landscapes Gut Microbes (IF 12.2) Pub Date : 2024-09-04 Nayeon Kim, Chan Yeong Kim, Junyeong Ma, Sunmo Yang, Dong Jin Park, Sang-Jun Ha, Peter Belenky, Insuk Lee
Mouse gut microbiome research is pivotal for understanding the human gut microbiome, providing insights into disease modeling, host-microbe interactions, and the dietary influence on the gut microb...
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Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain Gut Microbes (IF 12.2) Pub Date : 2024-09-04 Luca Falzone, Alessandro Lavoro, Saverio Candido, Mario Salmeri, Antonino Zanghì, Massimo Libra
Recently, the mounting integration of probiotics into human health strategies has gathered considerable attention. Although the benefits of probiotics have been widely recognized in patients with g...
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Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation. Gut Microbes (IF 12.2) Pub Date : 2024-09-03 Maite Casado-Bedmar,Maryline Roy,Louis Berthet,Jean-Pierre Hugot,Chunhua Yang,Hana Manceau,Katell Peoc'h,Benoit Chassaing,Didier Merlin,Emilie Viennois
Inflammatory bowel diseases (IBD) etiology is multifactorial. Luminal microRNAs (miRNAs) have been suspected to play a role in the promotion of chronic inflammation, but the extent to which fecal miRNAs are interacting with the intestinal ecosystem in a way that contribute to diseases, including IBD, remains unknown. Here, fecal let-7b and miR-21 were found elevated, associated with inflammation, and
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Ethanol-induced changes to the gut microbiome compromise the intestinal homeostasis: a review. Gut Microbes (IF 12.2) Pub Date : 2024-09-03 Konrad Sosnowski,Adam Przybyłkowski
The intestine is the largest organ in terms of surface area in the human body. It is responsible not only for absorbing nutrients but also for protection against the external world. The gut microbiota is essential in maintaining a properly functioning intestinal barrier, primarily through producing its metabolites: short-chain fatty acids, bile acids, and tryptophan derivatives. Ethanol overconsumption
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Prevention and cure of murine C. difficile infection by a Lachnospiraceae strain Gut Microbes (IF 12.2) Pub Date : 2024-08-27 Juan Noriega Tejada, William A. Walters, Yanling Wang, Melissa Kordahi, Benoit Chassaing, Joseph Pickard, Gabriel Nunez, Ruth Ley, Andrew T. Gewirtz
We sought to better understand how intestinal microbiota confer protection against Clostridioides difficile (C. difficile) infection (CDI). We utilized gnotobiotic altered Schaedler flora (ASF) mic...
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Consistent signatures in the human gut microbiome of longevous populations Gut Microbes (IF 12.2) Pub Date : 2024-08-28 Shu Chen, Zhao Zhang, Sanxin Liu, Tao Chen, Zhengqi Lu, Wenjing Zhao, Xiangyu Mou, Sheng Liu
Gut microbiota of centenarians has garnered significant attention in recent years, with most studies concentrating on the analysis of microbial composition. However, there is still limited knowledg...
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Gut microbiome profiles to exclude the diagnosis of hepatic encephalopathy in patients with cirrhosis Gut Microbes (IF 12.2) Pub Date : 2024-08-27 Jasmohan S Bajaj, Jacqueline G O’Leary, Sofia S Jakab, Andrew Fagan, Masoumeh Sikaroodi, Patrick M Gillevet
Patients with cirrhosis who have cognitive complaints are presumed to have hepatic encephalopathy (HE), which leads to unwarranted medications while ignoring the underlying disease process causing ...
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Microbiota–gut–brain axis: interplay between microbiota, barrier function and lymphatic system Gut Microbes (IF 12.2) Pub Date : 2024-08-25 Miaomiao Zhuang, Xun Zhang, Jun Cai
The human gastrointestinal tract, boasting the most diverse microbial community, harbors approximately 100 trillion microorganisms comprising viruses, bacteria, fungi, and archaea. The profound gen...
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Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice Gut Microbes (IF 12.2) Pub Date : 2024-08-25 Paula M. Chilton, Smita S. Ghare, Benjamin T. Charpentier, Scott A. Myers, Aakarsha V. Rao, Joseph F. Petrosino, Kristi L. Hoffman, John C. Greenwell, Neetu Tyagi, Jyotirmaya Behera, Yali Wang, Lucy J. Sloan, JingWen Zhang, Christopher B. Shields, Gregory E. Cooper, Leila Gobejishvili, Scott R. Whittemore, Craig J. McClain, Shirish S. Barve
Alterations in the gut-microbiome-brain axis are increasingly being recognized to be involved in Alzheimer’s disease (AD) pathogenesis. However, the functional consequences of enteric dysbiosis lin...
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Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion Gut Microbes (IF 12.2) Pub Date : 2024-08-29 Lingyi Wu, Jianchun Zhou, An Zhou, Yuanyuan Lei, Li Tang, Shiping Hu, Sumin Wang, Xu Xiao, Qiao Chen, Dianji Tu, Cheng Lu, Yi Lai, Yiding Li, Xiao Zhang, Bo Tang, Shiming Yang
Gut microbiota dysbiosis is involved in cholestatic liver diseases. However, the mechanisms remain to be elucidated. The purpose of this study was to examine the effects and mechanisms of Lactobaci...
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Synergism of Fusobacterium periodonticum and N-nitrosamines promote the formation of EMT subtypes in ESCC by modulating Wnt3a palmitoylation Gut Microbes (IF 12.2) Pub Date : 2024-08-28 Mingjun Sun, Zhenyan Peng, Weitao Shen, Xinxin Guo, Yinghao Liao, Yang Huang, Ping Ye, Mohan Hu, Qiang Lin, Ran Liu
N-Nitrosamine disinfection by-products (NAs-DBPs) have been well proven for its role in esophageal carcinogenesis. However, the role of intratumoral microorganisms in esophageal squamous cell carci...
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Gut microbiota mediates anxiety-like behaviors induced by chronic infection of Toxoplasma gondii in mice Gut Microbes (IF 12.2) Pub Date : 2024-08-25 Xiaotong Luo, Xiaoying Yang, Shimin Tan, Yongsheng Zhang, Yunqiu Liu, Xiaokang Tian, Yingting Huang, Yuying Zhou, Cheng He, Kun Yin, Daxiang Xu, Xiangyang Li, Fenfen Sun, Renxian Tang, Jianping Cao, Kuiyang Zheng, Yinghua Yu, Wei Pan
Chronic infection with the neurotropic parasite Toxoplasma gondii (T. gondii) can cause anxiety and gut microbiota dysbiosis in hosts. However, the potential role of gut microbiota in anxiety induc...
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Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity Gut Microbes (IF 12.2) Pub Date : 2024-08-25 Kelly M. Jardon, Gijs H. Goossens, Jasper Most, Gianluca Galazzo, Koen Venema, John Penders, Ellen E. Blaak
Polyphenols exert beneficial effects on host metabolism, which may be mediated by the gut microbiota. We investigated sex-specific differences in microbiota composition and interactions with cardio...
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Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27 Gut Microbes (IF 12.2) Pub Date : 2024-08-27 Kaitlyn Grando, Shingo Bessho, Kayla Harrell, Kathrine Kyrylchuk, Alejandro M. Pantoja, Sophia Olubajo, Francisco J. Albicoro, Andres Klein-Szanto, Çagla Tükel
Salmonella enterica serovar Typhimurium (STm) causes gastroenteritis and can progress to reactive arthritis (ReA). STm forms biofilms in the gut that secrete the amyloid curli, which we previously ...
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Microbiota and glioma: a new perspective from association to clinical translation Gut Microbes (IF 12.2) Pub Date : 2024-08-26 Wenhui Wang, Zihao Ou, Xixin Huang, Jingyu Wang, Qianbei Li, Minghui Wen, Lei Zheng
Gliomas pose a significant challenge in oncology due to their malignant nature, aggressive growth, frequent recurrence, and complications posed by the blood-brain barrier. Emerging research has rev...
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Gut virome and microbiome dynamics before and after SARS-CoV-2 infection in women living with HIV and their infants Gut Microbes (IF 12.2) Pub Date : 2024-08-26 Rabia Maqsood, LaRinda A. Holland, Lily I. Wu, Emily R. Begnel, Judith Adhiambo, Prestone Owiti, Bhavna H. Chohan, Soren Gantt, John Kinuthia, Dalton Wamalwa, Ednah Ojee, Barbra A. Richardson, Jennifer Slyker, Dara A. Lehman, Efrem S. Lim
Microbiome perturbations can have long-term effects on health. The dynamics of the gut microbiome and virome in women living with HIV (WLHIV) and their newborn infants is poorly understood. Here, w...
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Effects of postbiotics on chronic diarrhea in young adults: a randomized, double-blind, placebo-controlled crossover trial assessing clinical symptoms, gut microbiota, and metabolite profiles. Gut Microbes (IF 12.2) Pub Date : 2024-08-27 Shuai Guo,Teng Ma,Lai-Yu Kwok,Keyu Quan,Bohai Li,Huan Wang,Heping Zhang,Bilige Menghe,Yongfu Chen
Chronic diarrhea has a considerable impact on quality of life. This randomized, double-blind, placebo-controlled crossover intervention trial was conducted with 69 participants (36 in Group A, 33 in Group B), aiming to investigate the potential of postbiotics in alleviating diarrhea-associated symptoms. Participants received postbiotic Probio-Eco® and placebo for 21 days each in alternating order,
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Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling Gut Microbes (IF 12.2) Pub Date : 2024-08-18 Ruijia Feng, Wenchao Yang, Weiqi Feng, Xiuyi Huang, Meifeng Cen, Guiyan Peng, Wenrui Wu, Zhecun Wang, Yexiang Jing, Ting Long, Yunchong Liu, Zilun Li, Guangqi Chang, Kan Huang
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in N...
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Fecal virus-like particles are sufficient to reduce necrotizing enterocolitis Gut Microbes (IF 12.2) Pub Date : 2024-08-22 Simone Margaard Offersen, Xiaotian Mao, Malene Roed Spiegelhauer, Frej Larsen, Viktoria Rose Li, Dennis Sandris Nielsen, Lise Aunsholt, Thomas Thymann, Anders Brunse
Fecal filtrate transfer (FFT) is emerging as a safer alternative to traditional fecal microbiota transplantation (FMT) – particularly in the context of necrotizing enterocolitis (NEC), a severe gas...
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Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2 Gut Microbes (IF 12.2) Pub Date : 2024-08-22 Liam Emile Rondeau, Bruna Barbosa Da Luz, Alba Santiago, Miriam Bermudez-Brito, Amber Hann, Giada De Palma, Jennifer Jury, Xuanyu Wang, Elena Francisca Verdu, Heather Jean Galipeau, Corinne Rolland, Celine Deraison, Wolfram Ruf, Premysl Bercik, Nathalie Vergnolle, Alberto Caminero
Imbalances in proteolytic activity have been linked to the development of inflammatory bowel diseases (IBD) and experimental colitis. Proteases in the intestine play important roles in maintaining ...
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Limited predictive value of the gut microbiome and metabolome for response to biological therapy in inflammatory bowel disease Gut Microbes (IF 12.2) Pub Date : 2024-08-21 Femke M. Prins, Iwan J. Hidding, Marjolein A.Y. Klaassen, Valerie Collij, Johannes P.D. Schultheiss, Werna T.C. Uniken Venema, Amber Bangma, Jurne B. Aardema, Bernadien H. Jansen, Wout G.N. Mares, Ben J.M. Witteman, Eleonora A.M. Festen, Gerard Dijkstra, Marijn C. Visschedijk, Herma H. Fidder, Arnau Vich Vila, Bas Oldenburg, Ranko Gacesa, Rinse K. Weersma
Emerging evidence suggests the gut microbiome’s potential in predicting response to biologic treatments in patients with inflammatory bowel disease (IBD). In this prospective study, we aimed to pre...
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Role of bacteriophages in shaping gut microbial community Gut Microbes (IF 12.2) Pub Date : 2024-08-21 Md. Rayhan Mahmud, Sanjida Khanam Tamanna, Sharmin Akter, Lincon Mazumder, Sumona Akter, Md. Rakibul Hasan, Mrityunjoy Acharjee, Israt Zahan Esti, Md. Saidul Islam, Md. Maksudur Rahman Shihab, Md. Nahian, Rubaiya Gulshan, Sadia Naser, Anna Maria Pirttilä
Phages are the most diversified and dominant members of the gut virobiota. They play a crucial role in shaping the structure and function of the gut microbial community and consequently the health ...
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Machine learning-causal inference based on multi-omics data reveals the association of altered gut bacteria and bile acid metabolism with neonatal jaundice Gut Microbes (IF 12.2) Pub Date : 2024-08-21 Wanling Chen, Peng Zhang, Xueli Zhang, Tiantian Xiao, Jianhai Zeng, Kaiping Guo, Huixian Qiu, Guoqiang Cheng, Zhangxing Wang, Wenhao Zhou, Shujuan Zeng, Mingbang Wang
Early identification of neonatal jaundice (NJ) appears to be essential to avoid bilirubin encephalopathy and neurological sequelae. The interaction between gut microbiota and metabolites plays an i...
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Dietary fiber for the prevention of childhood obesity: a focus on the involvement of the gut microbiota Gut Microbes (IF 12.2) Pub Date : 2024-08-20 Zhongmin Yang, Mingyue Yang, Edward C. Deehan, Chenxi Cai, Karen L. Madsen, Eytan Wine, Guiling Li, Jian Li, Jingwen Liu, Zhengxiao Zhang
Given the worldwide epidemic of overweight and obesity among children, evidence-based dietary recommendations are fundamentally important for obesity prevention. Although the significance of the hu...
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Disentangle beneficial effects of strain engraftment after fecal microbiota transplantation in subjects with MetSyn Gut Microbes (IF 12.2) Pub Date : 2024-08-20 Eduard W. J. van der Vossen, Mark Davids, Bas Voermans, Koen Wortelboer, Annick V. Hartstra, Annefleur M. Koopen, Pieter de Groot, Evgeni Levin, Max Nieuwdorp
Fecal Microbiota Transplantation (FMT) has emerged as a potential modality for mitigating microbiome-associated diseases. Despite this potential, the precise causal pathways by which specific gut m...
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Chronic binge drinking-induced susceptibility to colonic inflammation is microbiome-dependent Gut Microbes (IF 12.2) Pub Date : 2024-08-20 Diogo Fonseca-Pereira, Sena Bae, Monia Michaud, Jonathan N. Glickman, Wendy S. Garrett
Alterations in intestinal permeability and the gut microbiome caused by alcohol abuse are associated with alcoholic liver disease and with worsening of inflammatory bowel diseases (IBD) symptoms. T...
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Quercetin activates energy expenditure to combat metabolic syndrome through modulating gut microbiota-bile acids crosstalk in mice Gut Microbes (IF 12.2) Pub Date : 2024-08-20 Xiaoqiang Zhu, Xiaojuan Dai, Lijun Zhao, Jing Li, Yanhong Zhu, Wenjuan He, Xinlei Guan, Tao Wu, Li Liu, Hongping Song, Liang Lei
Abdominal obesity-related metabolic syndrome (MetS) has emerged as a significant global public health issue that affects human health. Flavonoids, such as quercetin, have been reported to exert obv...
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Microbiota and plasticity of antigen-presenting ILC3s: impact on antitumor immune response Gut Microbes (IF 12.2) Pub Date : 2024-08-19 Alessia Calabrò, Fabiana Drommi, Claudia De Pasquale, Giuseppe Navarra, Paolo Carrega, Irene Bonaccorsi, Guido Ferlazzo, Stefania Campana
Growing evidence highlights the pivotal role of RORγt-innate lymphoid cells (ILCs) in the establishment of antitumor immune response and in enhancing tumor sensitivity to immunotherapy. Noteworthy,...
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Microbiota during pregnancy and early life: role in maternal−neonatal outcomes based on human evidence Gut Microbes (IF 12.2) Pub Date : 2024-08-19 Alessio Fasano, Benoit Chassaing, Dirk Haller, Eduard Flores Ventura, Maria Carmen-Collado, Nitida Pastor, Omry Koren, Roberto Berni Canani
Here, we explored the vast potential of microbiome-based interventions in preventing and managing non-communicable diseases including obesity, diabetes, allergies, celiac disease, inflammatory bowe...
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Microbial metabolism marvels: a comprehensive review of microbial drug transformation capabilities Gut Microbes (IF 12.2) Pub Date : 2024-08-16 Filippo Martinelli, Ines Thiele
This comprehensive review elucidates the pivotal role of microbes in drug metabolism, synthesizing insights from an exhaustive analysis of over two hundred papers. Employing a structural classifica...
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Deciphering internal and external factors influencing intestinal junctional complexes Gut Microbes (IF 12.2) Pub Date : 2024-08-16 Zachary Markovich, Adriana Abreu, Yi Sheng, Sung Min Han, Rui Xiao
The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the intricate exchange between internal and external environments. Anchored by evolutionarily conserved juncti...
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Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion Gut Microbes (IF 12.2) Pub Date : 2024-08-12 Angélica Díaz-Basabe, Georgia Lattanzi, Federica Perillo, Chiara Amoroso, Alberto Baeri, Andrea Farini, Yvan Torrente, Giuseppe Penna, Maria Rescigno, Michele Ghidini, Elisa Cassinotti, Ludovica Baldari, Luigi Boni, Maurizio Vecchi, Flavio Caprioli, Federica Facciotti, Francesco Strati
The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences the anti-tu...
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Gene content, phage cycle regulation model and prophage inactivation disclosed by prophage genomics in the Helicobacter pylori Genome Project Gut Microbes (IF 12.2) Pub Date : 2024-08-12 Filipa F. Vale, Richard J. Roberts, Ichizo Kobayashi, M. Constanza Camargo, Charles S. Rabkin
Prophages can have major clinical implications through their ability to change pathogenic bacterial traits. There is limited understanding of the prophage role in ecological, evolutionary, adaptive...
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The early life exposome and autism risk: a role for the maternal microbiome? Gut Microbes (IF 12.2) Pub Date : 2024-08-09 Claudia M. Di Gesù, Shelly A. Buffington
Autism spectrum disorders (ASD) are highly heritable, heterogeneous neurodevelopmental disorders characterized by clinical presentation of atypical social, communicative, and repetitive behaviors. ...
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Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa Gut Microbes (IF 12.2) Pub Date : 2024-08-12 Amanda Mandarino Alves, Chiara Lecchi, Sharon Lopez, Alessia Stornetta, Prince P. Mathai, Peter W. Villalta, Satoshi Ishii, Emily P. Balskus, Silvia Balbo, Alexander Khoruts
Colibactin is a recently characterized pro-carcinogenic genotoxin produced by pks+ Escherichia coli. We hypothesized that cystic fibrosis (CF)-associated dysfunctional mucus structure increases the...
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Comparison of gnotobiotic communities reveals milk-adapted metabolic functions and unexpected amino acid metabolism by the pre-weaning microbiome Gut Microbes (IF 12.2) Pub Date : 2024-08-12 Jean-Bernard Lubin, Michael A. Silverman, Paul J. Planet
The intestinal microbiome during infancy and childhood has distinct metabolic functions and microbial composition compared to adults. We recently published a gnotobiotic mouse model of the pre-wean...
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Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin Gut Microbes (IF 12.2) Pub Date : 2024-08-12 Jingpeng Yang, Wen Rui, Saiwei Zhong, Xiaoqian Li, Wenzheng Liu, Lingtong Meng, Yanan Li, He Huang
Vancomycin (VAN) treatment in Clostridioides difficile infection (CDI) suffers from a relatively high rate of recurrence, with a variety of reasons behind this, including biofilm-induced recurrent ...
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The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC Gut Microbes (IF 12.2) Pub Date : 2024-08-06 Huiyong Jiang, Ying Yu, Xiaoxiang Hu, Bingbing Du, Yini Shao, Feiyu Wang, Lifeng Chen, Ren Yan, Lanjuan Li, Longxian Lv
The role of the gut microbiota in the occurrence and progression of primary biliary cholangitis (PBC) is not fully understood. First, the fecal microbiota of patients with PBC (n = 4) (PBC-FMT) or ...
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Supplier-origin gut microbiomes affect host body weight and select autism-related behaviors Gut Microbes (IF 12.2) Pub Date : 2024-08-06 Zachary L McAdams, Kevin L Gustafson, Amber L Russell, Rachel Self, Amy L Petry, Teresa E Lever, Aaron C Ericsson
Autism spectrum disorders (ASD) are complex human neurodiversities increasing in prevalence within the human population. In search of therapeutics to improve quality-of-life for ASD patients, the g...
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Pseudocin 196, a novel lantibiotic produced by Bifidobacterium pseudocatenulatum elicits antimicrobial activity against clinically relevant pathogens Gut Microbes (IF 12.2) Pub Date : 2024-08-06 Rocio Sanchez-Gallardo, Paula M. O’Connor, Ian J. O’Neill, Brian McDonnell, Ciaran Lee, Rebecca L. Moore, Fionnuala M. McAuliffe, Paul D. Cotter, Douwe van Sinderen
Bacteriocins are broad or narrow-spectrum antimicrobial compounds that have received significant scientific attention due to their potential to treat infections caused by antibiotic-resistant patho...
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Game of microbes: the battle within – gut microbiota and multiple sclerosis Gut Microbes (IF 12.2) Pub Date : 2024-08-08 Ti-Ara Turner, Peter Lehman, Sudeep Ghimire, Shailesh K. Shahi, Ashutosh Mangalam
Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the dise...