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BaiJ and BaiB are key enzymes in the chenodeoxycholic acid 7α-dehydroxylation pathway in the gut microbe Clostridium scindens ATCC 35704 Gut Microbes (IF 12.2) Pub Date : 2024-03-11 Karin Lederballe Meibom, Solenne Marion, Colin Volet, Théo Nass, Eduard Vico-Oton, Laure Menin, Rizlan Bernier-Latmani
Bile acid transformation is a common gut microbiome activity that produces secondary bile acids, some of which are important for human health. One such process, 7α-dehydroxylation, converts the pri...
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Stress in the microbiome-immune crosstalk Gut Microbes (IF 12.2) Pub Date : 2024-03-15 Eléonore Beurel
The gut microbiota exerts a mutualistic interaction with the host in a fragile ecosystem and the host intestinal, neural, and immune cells. Perturbations of the gastrointestinal track composition a...
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Long- and short-term effects of fecal microbiota transplantation on antibiotic resistance genes: results from a randomized placebo-controlled trial Gut Microbes (IF 12.2) Pub Date : 2024-03-13 Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, David Kazadi, Hossam Halaweish, Mohammad H. Khan, Andrea Hoeschen, Qing Cao, Xianghua Luo, Amanda J. Kabage, Sharon Lopez, Shernan G. Holtan, Daniel J. Weisdorf, Chang Liu, Satoshi Ishii, Alexander Khoruts, Christopher Staley
In small series, third-party fecal microbiota transplantation (FMT) has been successful in decolonizing the gut from clinically relevant antibiotic resistance genes (ARGs). Less is known about the ...
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ZntA maintains zinc and cadmium homeostasis and promotes oxidative stress resistance and virulence in Vibrio parahaemolyticus Gut Microbes (IF 12.2) Pub Date : 2024-03-11 Chengkun Zheng, Yimeng Zhai, Jun Qiu, Mengxian Wang, Zhengzhong Xu, Xiang Chen, Xiaohui Zhou, Xinan Jiao
Although metals are essential for life, they are toxic to bacteria in excessive amounts. Therefore, the maintenance of metal homeostasis is critical for bacterial physiology and pathogenesis. Vibri...
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Modulation of chronic obstructive pulmonary disease progression by antioxidant metabolites from Pediococcus pentosaceus: enhancing gut probiotics abundance and the tryptophan-melatonin pathway Gut Microbes (IF 12.2) Pub Date : 2024-03-06 Yiting Liu, Longjie Li, Jing Feng, Bing Wan, Qiang Tu, Wei Cai, Fa Jin, Guiying Tang, Lígia R. Rodrigues, Xiuwei Zhang, Jia Yin, Yunlei Zhang
Chronic obstructive pulmonary disease (COPD), a condition primarily linked to oxidative stress, poses significant health burdens worldwide. Recent evidence has shed light on the association between...
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A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms Gut Microbes (IF 12.2) Pub Date : 2024-03-06 Gwoncheol Park, Saurabh Kadyan, Nathaniel Hochuli, Julie Pollak, Bo Wang, Gloria Salazar, Paramita Chakrabarty, Philip Efron, Julia Sheffler, Ravinder Nagpal
Alzheimer’s disease (AD) is a debilitating brain disorder with rapidly mounting prevalence worldwide, yet no proven AD cure has been discovered. Using a multi-omics approach in a transgenic AD mous...
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Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection Gut Microbes (IF 12.2) Pub Date : 2024-03-06 Séverine Heumel, Vinícius de Rezende Rodovalho, Charlotte Urien, Florian Specque, Patrícia Brito Rodrigues, Cyril Robil, Lou Delval, Valentin Sencio, Amandine Descat, Lucie Deruyter, Stéphanie Ferreira, Marina Gomes Machado, Adeline Barthelemy, Fabiola Silva Angulo, Joel. T Haas, Jean François Goosens, Isabelle Wolowczuk, Corinne Grangette, Yves Rouillé, Ghjuvan Grimaud, Marie Lenski, Benjamin Hennart
The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolo...
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Bifidobacterium alleviate metabolic disorders via converting methionine to 5’-methylthioadenosine Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Qiang Lyu, Rou-An Chen, Hsiao-Li Chuang, Hsin-Bai Zou, Lihong Liu, Li-Kang Sung, Po-Yu Liu, Hsin-Yi Wu, Hsin-Yuan Chang, Wan-Ju Cheng, Wei-Kai Wu, Ming-Shiang Wu, Cheng-Chih Hsu
Dietary patterns and corresponding gut microbiota profiles are associated with various health conditions. A diet rich in polyphenols, primarily plant-based, has been shown to promote the growth of ...
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IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Wenjie Tang, Yusen Wei, Zhixiang Ni, Kangwei Hou, Xin M. Luo, Haifeng Wang
The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-me...
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Bile acid profiling as an effective biomarker for staging in pediatric inflammatory bowel disease Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Wei Chen, Daosheng Wang, Xing Deng, Hong Zhang, Danfeng Dong, Tongxuan Su, Qiuya Lu, Cen Jiang, Qi Ni, Yingchao Cui, Qianli Zhao, Xuefeng Wang, Yuan Xiao, Yibing Peng
Rapid and accurate clinical staging of pediatric patients with inflammatory bowel disease (IBD) is crucial to determine the appropriate therapeutic approach. This study aimed to identify effective,...
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A metagenomic prospective cohort study on gut microbiome composition and clinical infection in small bowel transplantation Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Archana Madhav, Rachel Bousfield, Joana Pereira-Dias, Claire Cormie, Sally Forrest, Jacqueline Keane, Leanne Kermack, Ellen Higginson, Gordon Dougan, Harry Spiers, Dunecan Massey, Lisa Sharkey, Charlotte Rutter, Jeremy Woodward, Neil Russell, Irum Amin, Andrew Butler, Kayleigh Atkinson, Tom Dymond, Josefin Bartholdson Scott, Stephen Baker, Effrossyni Gkrania-Klotsas
Two-thirds of small-bowel transplantation (SBT) recipients develop bacteremia, with the majority of infections occurring within 3 months post-transplant. Sepsis-related mortality occurs in 31% of p...
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Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Lei Zhang, Ziyan Liu, Wei Zhang, Jingyu Wang, Huiwen Kang, Jiaru Jing, Lin Han, Ai Gao
Due to the annual increase in its production and consumption in occupational environments, the adverse blood outcomes caused by benzene are of concern. However, the mechanism of benzene-induced hem...
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Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity Gut Microbes (IF 12.2) Pub Date : 2024-03-04 Ye Peng, Hein M Tun, Siew C Ng, Hogan Kok-Fung Wai, Xi Zhang, Jaclyn Parks, Catherine J Field, Piush Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, Jeffrey R Brook, Tim K Takaro, James A Scott, Francis KL Chan, Anita L Kozyrskyj
Childhood obesity is linked to maternal smoking during pregnancy. Gut microbiota may partially mediate this association and could be potential targets for intervention; however, its role is underst...
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A metatranscriptomics strategy for efficient characterization of the microbiome in human tissues with low microbial biomass Gut Microbes (IF 12.2) Pub Date : 2024-02-29 Joana Pereira-Marques, Rui M. Ferreira, Ceu Figueiredo
The high background of host RNA poses a major challenge to metatranscriptome analysis of human samples. Hence, metatranscriptomics has been mainly applied to microbe-rich samples, while its applica...
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Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation Gut Microbes (IF 12.2) Pub Date : 2024-02-27 Bozhong Shi, Haoyu Li, Xiaomin He
The gut microbiome is known as the tenth system of the human body that plays a vital role in the intersection between health and disease. The considerable inter-individual variability in gut microb...
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The colibactin-producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance Gut Microbes (IF 12.2) Pub Date : 2024-02-28 Nilmara de Oliveira Alves, Guillaume Dalmasso, Darja Nikitina, Amaury Vaysse, Richard Ruez, Lea Ledoux, Thierry Pedron, Emma Bergsten, Olivier Boulard, Lora Autier, Sofian Allam, Laurence Motreff, Pierre Sauvanet, Diane Letourneur, Pragya Kashyap, Johan Gagnière, Denis Pezet, Catherine Godfraind, Michel Salzet, Emmanuel Lemichez, Mathilde Bonnet, Imène Najjar, Christophe Malabat, Marc Monot, Denis
Intratumoral bacteria flexibly contribute to cellular and molecular tumor heterogeneity for supporting cancer recurrence through poorly understood mechanisms. Using spatial metabolomic profiling te...
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Multi-omics reveals deoxycholic acid modulates bile acid metabolism via the gut microbiota to antagonize carbon tetrachloride-induced chronic liver injury Gut Microbes (IF 12.2) Pub Date : 2024-02-28 Li Zhang, Zhiyi Zheng, Huanhuan Huang, Ya Fu, Tianbin Chen, Can Liu, Qiang Yi, Caorui Lin, Yongjun Zeng, Qishui Ou, Yongbin Zeng
Deoxycholic acid (DCA) serves essential functions in both physiological and pathological liver processes; nevertheless, the relationship among DCA, gut microbiota, and metabolism in chronic liver i...
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The intestinal microbiome of inflammatory bowel disease across the pediatric age range Gut Microbes (IF 12.2) Pub Date : 2024-02-25 Máire A. Conrad, Kyle Bittinger, Yue Ren, Kelly Kachelries, Jennifer Vales, Hongzhe Li, Gary D. Wu, Frederic D. Bushman, Marcella Devoto, Robert N Baldassano, Judith R. Kelsen
Dysbiosis is associated with pediatric and adult-onset inflammatory bowel disease (IBD), but the role of dysbiosis and the microbiome in very early onset IBD (VEO-IBD) has not yet been described. H...
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Regulation of colonic neuropeptide Y expression by the gut microbiome in patients with ulcerative colitis and its association with anxiety- and depression-like behavior in mice Gut Microbes (IF 12.2) Pub Date : 2024-02-25 Min-Kyung Joo, Jae-Won Lee, Jeong-Hwa Woo, Hyo-Jong Kim, Dong-Hyun Kim, Jung-Hye Choi
Patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC), show an increased incidence of anxiety and depression; however, the association between UC-associated psychiatric ...
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Roles of microbiota in pancreatic cancer development and treatment Gut Microbes (IF 12.2) Pub Date : 2024-02-27 Mariana Santos Cruz, Joseph Tintelnot, Nicola Gagliani
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This is due to the fact that most cases are only diagnosed at an advanced and palliative disease stage, and the...
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The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk Gut Microbes (IF 12.2) Pub Date : 2024-02-23 Sirena C. Tran, Kaeli N. Bryant, Timothy L. Cover
Helicobacter pylori strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the cag pathogenicity island (cag PAI). Colonization of the...
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A tailored series of engineered yeasts for the cell-dependent treatment of inflammatory bowel disease by rational butyrate supplementation Gut Microbes (IF 12.2) Pub Date : 2024-02-21 Jiahao Wu, He Huang, Lina Wang, Mengxue Gao, Shuxian Meng, Shaolan Zou, Yuanhang Feng, Zeling Feng, Zhixin Zhu, Xiaocang Cao, Bingzhi Li, Guangbo Kang
Intestinal microbiota dysbiosis and metabolic disruption are considered essential characteristics in inflammatory bowel disorders (IBD). Reasonable butyrate supplementation can help patients regula...
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S-amlodipine induces liver inflammation and dysfunction through the alteration of intestinal microbiome in a rat model Gut Microbes (IF 12.2) Pub Date : 2024-02-24 Xinxin Liu, Hui Fang, Liuzhu Pan, Peng Zhang, Huai Lin, Huihui Gao, Chaolin Ye, Daqing Mao, Yi Luo
S-amlodipine, a commonly prescribed antihypertensive agent, is widely used in clinical settings to treat hypertension. However, the potential adverse effects of long-term S-amlodipine treatment on ...
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Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages Gut Microbes (IF 12.2) Pub Date : 2024-02-24 Zhen He, Hongyu Xie, Haoyang Xu, Jinjie Wu, Wanyi Zeng, Qilang He, Christian Jobin, Sanqing Jin, Ping Lan
The gut microbiota has been shown to influence the efficacy and toxicity of chemotherapy, thereby affecting treatment outcomes. Understanding the mechanism by which microbiota affects chemotherapeu...
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B. longum CKD1 enhances the efficacy of anti-diabetic medicines through upregulation of IL- 22 response in type 2 diabetic mice Gut Microbes (IF 12.2) Pub Date : 2024-02-23 Won Jun Kim, Bum Ju Kil, Chaewon Lee, Tae Young Kim, Goeun Han, Yukyung Choi, Kyunghwan Kim, Chang Hun Shin, Seung-Young Park, Heebal Kim, Myunghoo Kim, Chul Sung Huh
The gut microbiota plays a pivotal role in metabolic disorders, notably type 2 diabetes mellitus (T2DM). In this study, we investigated the synergistic potential of combining the effects of Bifidob...
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Colibactin-producing Escherichia coli enhance resistance to chemotherapeutic drugs by promoting epithelial to mesenchymal transition and cancer stem cell emergence Gut Microbes (IF 12.2) Pub Date : 2024-02-19 Guillaume Dalmasso, Antony Cougnoux, Tiphanie Faïs, Virginie Bonnin, Benoit Mottet-Auselo, Hang TT Nguyen, Pierre Sauvanet, Nicolas Barnich, Marine Jary, Denis Pezet, Julien Delmas, Richard Bonnet
Human colorectal cancers (CRCs) are readily colonized by colibactin-producing E. coli (CoPEC). CoPEC induces DNA double-strand breaks, DNA mutations, genomic instability, and cellular senescence. I...
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The biotherapeutic Clostridium butyricum MIYAIRI 588 strain potentiates enterotropism of Rorγt+Treg and PD-1 blockade efficacy Gut Microbes (IF 12.2) Pub Date : 2024-02-22 Thomas Paz Del Socorro, Kentaro Oka, Olivier Boulard, Motomichi Takahashi, Lionel Franz Poulin, Atsushi Hayashi, Mathias Chamaillard
Immune checkpoint inhibitors (ICI) have been positioned as a standard of care for patients with advanced non-small-cell lung carcinomas (NSCLC). A pilot clinical trial has reflected optimistic asso...
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Dietary resistant starch supplementation increases gut luminal deoxycholic acid abundance in mice Gut Microbes (IF 12.2) Pub Date : 2024-02-20 Melanie A. Reuter, Madelynn Tucker, Zara Marfori, Rahaf Shishani, Jessica Miranda Bustamante, Rosalinda Moreno, Michael L. Goodson, Allison Ehrlich, Ameer Y. Taha, Pamela J. Lein, Nikhil Joshi, Ilana Brito, Blythe Durbin-Johnson, Renu Nandakumar, Bethany P. Cummings
Bile acids (BA) are among the most abundant metabolites produced by the gut microbiome. Primary BAs produced in the liver are converted by gut bacterial 7-α-dehydroxylation into secondary BAs, whic...
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Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons Gut Microbes (IF 12.2) Pub Date : 2024-02-19 Shuk-Man Ho, Wan-Hua Tsai, Chih-Ho Lai, Meng-Hsuan Chiang, Wang-Po Lee, Hui-Yu Wu, Pei-Yi Bai, Tony Wu, Chia-Lin Wu
Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the ...
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Gut microbiota regulates host melatonin production through epithelial cell MyD88 Gut Microbes (IF 12.2) Pub Date : 2024-02-14 Bingnan Liu, Lijuan Fan, Youxia Wang, Hao Wang, Yuqi Yan, Shuai Chen, Ifen Hung, Chunxue Liu, Hong Wei, Liangpeng Ge, Wenkai Ren
Melatonin has various physiological effects, such as the maintenance of circadian rhythms, anti-inflammatory functions, and regulation of intestinal barriers. The regulatory functions of melatonin ...
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Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults Gut Microbes (IF 12.2) Pub Date : 2024-02-15 Paige E. Jamieson, Eli B. Smart, John A. Bouranis, Jaewoo Choi, Robert E. Danczak, Carmen P. Wong, Ines L. Paraiso, Claudia S. Maier, Emily Ho, Thomas J. Sharpton, Thomas O. Metz, Ryan Bradley, Jan F. Stevens
Xanthohumol (XN), a polyphenol found in the hop plant (Humulus lupulus), has antioxidant, anti-inflammatory, prebiotic, and anti-hyperlipidemic activity. Preclinical evidence suggests the gut micro...
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From a hunger-regulating hormone to an antimicrobial peptide: gastrointestinal derived circulating endocrine hormone-peptide YY exerts exocrine antimicrobial effects against selective gut microbiota Gut Microbes (IF 12.2) Pub Date : 2024-02-14 Yuchen Xiao, Lingjing Jin, Chao Zhang
Published in Gut Microbes (Vol. 16, No. 1, 2024)
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Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia Gut Microbes (IF 12.2) Pub Date : 2024-02-13 Jiayi Wang, Yajie Gao, Shuaijun Ren, Jialin Li, Siqian Chen, Jiating Feng, Bing He, Yuping Zhou, Rongrong Xuan
Pre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens the health and safety of the mother and child. Studies have shown that an imbalance in gut microbiota can aff...
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Salmonella enterica serovar Typhimurium remodels mitochondrial dynamics of macrophages via the T3SS effector SipA to promote intracellular proliferation Gut Microbes (IF 12.2) Pub Date : 2024-02-14 Xingmei Liu, Yutao Liu, Xinyu Zhao, Xueping Li, Ting Yao, Ruiying Liu, Qian Wang, Qiushi Wang, Dan Li, Xintong Chen, Bin Liu, Lu Feng
Mitochondrial dynamics are critical in cellular energy production, metabolism, apoptosis, and immune responses. Pathogenic bacteria have evolved sophisticated mechanisms to manipulate host cells’ m...
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The IBS bug-pain connection Gut Microbes (IF 12.2) Pub Date : 2024-02-08 Elena F Verdu, Stephen Vanner
Published in Gut Microbes (Vol. 16, No. 1, 2024)
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Weizmannia coagulans BCF-01: a novel gastrogenic probiotic for Helicobacter pylori infection control Gut Microbes (IF 12.2) Pub Date : 2024-02-09 Zhenhui Chen, Ziyu Tang, Wendan Li, Xiaoshi Deng, Lu Yu, Jixiang Yang, Jiaxin Liu, Yunshui Cheng, Wanwen Huang, Xiaotong Guo, Jiamin Shan, Daixuan Zhou, Weisen Zeng, Yang Bai, Hongying Fan
The widespread prevalence of Helicobacter pylori infection, particularly in China, contributes to the development of gastrointestinal diseases. Antibiotics have limitations, including adverse react...
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Vancomycin relieves tacrolimus-induced hyperglycemia by eliminating gut bacterial beta-glucuronidase enzyme activity Gut Microbes (IF 12.2) Pub Date : 2024-02-08 Peixia Li, Rui Zhang, Jinping Zhou, Pengpeng Guo, Yani Liu, Shaojun Shi
Up to 40% of transplant recipients treated long-term with tacrolimus (TAC) develop post-transplant diabetes mellitus (PTDM). TAC is an important risk factor for PTDM, but is also essential for immu...
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Prescription opioids induced microbial dysbiosis worsens severity of chronic pancreatitis and drives pain hypersensitivity Gut Microbes (IF 12.2) Pub Date : 2024-02-08 Kousik Kesh, Junyi Tao, Nillu Ghosh, Richa Jalodia, Salma Singh, Rajinder Dawra, Sabita Roy
Opioids, such as morphine and oxycodone, are widely used for pain management associated with chronic pancreatitis (CP); however, their impact on the progression and pain sensitivity of CP has never...
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Repeated (S)-ketamine administration ameliorates the spatial working memory impairment in mice with chronic pain: role of the gut microbiota–brain axis Gut Microbes (IF 12.2) Pub Date : 2024-02-08 Yubin Jiang, Xingming Wang, Jiawei Chen, Yibao Zhang, Kenji Hashimoto, Jian-Jun Yang, Zhiqiang Zhou
Chronic pain is commonly linked with diminished working memory. This study explores the impact of the anesthetic (S)-ketamine on spatial working memory in a chronic constriction injury (CCI) mouse ...
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Gut microbiota modulate CD8+ T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX Gut Microbes (IF 12.2) Pub Date : 2024-02-06 Xiang Yu, Jinzhou Ou, Lingzhi Wang, Zhenyuan Li, Yingxin Ren, Lang Xie, Zhian Chen, Junxian Liang, Guodong Shen, Zhaowei Zou, Cuiyin Zhao, Guoxin Li, Yanfeng Hu
The gut microbiota and Short-chain fatty acids (SCFAs) can influence the progression of diseases, yet the role of these factors on gastric cancer (GC) remains uncertain. In this work, the analysis ...
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Lack of gut microbiome recovery with spinal cord injury rehabilitation Gut Microbes (IF 12.2) Pub Date : 2024-02-07 Ayelet Gur Arie, Tamar Toren, Rotem Hadar, Tzipi Braun, Gilat Efroni, Efrat Glick Saar, Zecharia Madar, Amnon Amir, Gabriel Zeilig, Yael Haberman
Spinal cord injury (SCI) is a devastating event that significantly changes daily function and quality of life and is linked to bowel and bladder dysfunction and frequent antibiotic treatment. We ai...
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Phocaeicola vulgatus alleviates diet-induced metabolic dysfunction-associated steatotic liver disease progression by downregulating histone acetylation level via 3-HPAA Gut Microbes (IF 12.2) Pub Date : 2024-02-05 Shengxi Jin, Peng Chen, Jing Yang, Duguang Li, Xiaolong Liu, Yiyin Zhang, Qiming Xia, Yiling Li, Guoqiao Chen, Yixuan Li, Yifan Tong, Weihua Yu, Xiaoxiao Fan, Hui Lin
Diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder with limited effective interventions available. A novel approach to address this issu...
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Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy responses to anti-α4β7-integrin in Crohn’s disease Gut Microbes (IF 12.2) Pub Date : 2024-02-05 Bing Han, Daiyuan Tang, Xiaodan Lv, Junhua Fan, Shiquan Li, Hui Zhu, Jiatong Zhang, Shang Xu, Xiaofang Xu, Ziqian Huang, Zhixi Huang, Guangfu Lin, Lingling Zhan, Xiaoping Lv
Gut microbiota and related metabolites are both crucial factors that significantly influence how individuals with Crohn’s disease respond to immunotherapy. However, little is known about the interp...
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Gut microbiota-derived indole compounds attenuate metabolic dysfunction-associated steatotic liver disease by improving fat metabolism and inflammation Gut Microbes (IF 12.2) Pub Date : 2024-02-01 Byeong Hyun Min, Shivani Devi, Goo Hyun Kwon, Haripriya Gupta, Jin-Ju Jeong, Satya Priya Sharma, Sung-Min Won, Ki-Kwang Oh, Sang Jun Yoon, Hee Jin Park, Jung A Eom, Min Kyo Jeong, Ji Ye Hyun, Nattan Stalin, Tae-Sik Park, Jieun Choi, Do Yup Lee, Sang Hak Han, Dong Joon Kim, Ki Tae Suk
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, and its prevalence has increased worldwide in recent years. Additionally, there is a close...
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Effects of breastfeeding on children’s gut colonization with multidrug-resistant Enterobacterales in peri-urban Lima, Peru Gut Microbes (IF 12.2) Pub Date : 2024-02-01 Maya L. Nadimpalli, Luismarcelo Rojas Salvatierra, Subhra Chakraborty, Jenna M. Swarthout, Lilia Z. Cabrera, Amy J. Pickering, Maritza Calderon, Mayuko Saito, Robert H. Gilman, Monica J. Pajuelo
Children living in low-resource settings are frequently gut-colonized with multidrug-resistant bacteria. We explored whether breastfeeding may protect against children’s incident gut colonization w...
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Direct evidence of host-mediated glycosylation of NleA and its dependence on interaction with the COPII complex Gut Microbes (IF 12.2) Pub Date : 2024-02-01 Lindsay Burns, François Le Mauff, Samantha Gruenheid
Non-LEE-encoded Effector A (NleA) is a type III secreted effector protein of enterohaemorrhagic and enteropathogenic Escherichia coli as well as the related mouse pathogen Citrobacter rodentium. Nl...
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Fungal signature differentiates alcohol-associated liver disease from nonalcoholic fatty liver disease Gut Microbes (IF 12.2) Pub Date : 2024-02-01 Greta Viebahn, Phillipp Hartmann, Sonja Lang, Münevver Demir, Xinlian Zhang, Derrick E. Fouts, Peter Stärkel, Bernd Schnabl
The fungal microbiota plays an important role in the pathogenesis of alcohol-associated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). In this study, we aimed to compare changes ...
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A universe of human gut-derived bacterial prophages: unveiling the hidden viral players in intestinal microecology Gut Microbes (IF 12.2) Pub Date : 2024-02-01 Zhangming Pei, Yufei Liu, Yutao Chen, Tong Pan, Xihao Sun, Hongchao Wang, R. Paul Ross, Wenwei Lu, Wei Chen
Prophages, which are an existing form of temperate phages that integrate into host genomes, have been found extensively present in diverse bacterial species. The human gut microbiome, characterized...
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Microbiome function and neurodevelopment in Black infants: vitamin B12 emerges as a key factor Gut Microbes (IF 12.2) Pub Date : 2024-02-01 Kaitlyn Oliphant, Wilfredo Cruz Ayala, Rimma Ilyumzhinova, Kimberley Mbayiwa, Anna Sroka, Bingqing Xie, Bree Andrews, Kate Keenan, Erika C. Claud
The early life gut microbiome affects the developing brain, and therefore may serve as a target to support neurodevelopment of children living in stressful and under-resourced environments, such as...
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Exploring substrate–microbe interactions: a metabiotic approach toward developing targeted synbiotic compositions Gut Microbes (IF 12.2) Pub Date : 2024-02-01 Bodo Speckmann, Ellen Ehring, Jiaying Hu, Ana Rodriguez Mateos
Gut microbiota is an important modulator of human health and contributes to high inter-individual variation in response to food and pharmaceutical ingredients. The clinical outcomes of intervention...
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Citrobacter rodentium possesses a functional type II secretion system necessary for successful host infection Gut Microbes (IF 12.2) Pub Date : 2024-02-01 Z Krekhno, SE Woodward, A Serapio-Palacios, J Peña-Díaz, KM Moon, LJ Foster, BB Finlay
Infectious diarrheal diseases are the third leading cause of mortality in young children, many of which are driven by Gram-negative bacterial pathogens. To establish successful host infections thes...
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Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome Gut Microbes (IF 12.2) Pub Date : 2024-01-31 Nadia Andrea Andreani, Arunabh Sharma, Brigitte Dahmen, Hannah E. Specht, Nina Mannig, Vanessa Ruan, Lara Keller, John F. Baines, Beate Herpertz-Dahlmann, Astrid Dempfle, Jochen Seitz
There is mounting evidence regarding the role of gut microbiota in anorexia nervosa (AN). Previous studies have reported that patients with AN show dysbiosis compared to healthy controls (HCs); how...
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A gut aging clock using microbiome multi-view profiles is associated with health and frail risk Gut Microbes (IF 12.2) Pub Date : 2024-01-30 Hongchao Wang, Yutao Chen, Ling Feng, Shourong Lu, Jinlin Zhu, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu
Age-related changes in the microbiome have been reported in previous studies; however, direct evidence for their association with frailty is lacking. Here, we introduce biological age based on gut ...
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Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology Gut Microbes (IF 12.2) Pub Date : 2024-01-30 Lise Hunault, Emile Auria, Patrick England, Julien Deschamps, Romain Briandet, Vanessa Kremer, Bruno Iannascoli, Léo Vidal-Maison, Chunguang Guo, Lynn Macdonald, Séverine Péchiné, Cécile Denève-Larrazet, Bruno Dupuy, Guy Gorochov, Pierre Bruhns, Delphine Sterlin
Clostridioides difficile (C. difficile), a gram-positive anaerobic and spore-forming bacterium, is the leading cause of nosocomial antibiotic-associated diarrhea in adults which is characterized by...
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Antibiotic-induced gut dysbiosis elicits gut-brain axis relevant multi-omic signatures and behavioral and neuroendocrine changes in a nonhuman primate model Gut Microbes (IF 12.2) Pub Date : 2024-01-29 Shivdeep S. Hayer, Mackenzie Conrin, Jeffrey A. French, Andrew K. Benson, Sophie Alvarez, Kathryn Cooper, Anne Fischer, Zahraa Wajih Alsafwani, William Gasper, Mallory J. Suhr Van Haute, Haley R. Hassenstab, Shayda Azadmanesh, Missy Briardy, Skyler Gerbers, Aliyah Jabenis, Jennifer L. Thompson, Jonathan B. Clayton
Emerging evidence indicates that antibiotic-induced dysbiosis can play an etiological role in the pathogenesis of neuropsychiatric disorders. However, most of this evidence comes from rodent models...
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Microbial stars: shedding light on gut microbes’ role in insulin resistance and innovative diabetes therapies Gut Microbes (IF 12.2) Pub Date : 2024-01-26 Jinwei Zhang
The role of gut microbiota in insulin resistance (IR), Metabolic Syndrome (MetS), and Type 2 Diabetes Mellitus (T2DM) is rapidly gaining recognition. However, the mechanisms and implications of gut...
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Bacteroides thetaiotaomicron ameliorates mouse hepatic steatosis through regulating gut microbial composition, gut-liver folate and unsaturated fatty acids metabolism Gut Microbes (IF 12.2) Pub Date : 2024-01-26 Hu Li, Xue-Kai Wang, Mei Tang, Lei Lei, Jian-Rui Li, Han Sun, Jing Jiang, Biao Dong, Hong-Ying Li, Jian-Dong Jiang, Zong-Gen Peng
Gut microbiota plays an essential role in the progression of nonalcoholic fatty liver disease (NAFLD), making the gut-liver axis a potential therapeutic strategy. Bacteroides genus, the enriched gu...
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Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift Gut Microbes (IF 12.2) Pub Date : 2024-01-24 Deep Chanda, Debojyoti De
The majority of cohort-specific studies associating gut microbiota with obesity are often contradictory; thus, the replicability of the signature remains questionable. Moreover, the species that dr...
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B. thetaiotaomicron-derived acetic acid modulate immune microenvironment and tumor growth in hepatocellular carcinoma Gut Microbes (IF 12.2) Pub Date : 2024-01-25 Hongbin Ma, Liang Yang, Yingchao Liang, Fenghua Liu, Jinxiang Hu, Rui Zhang, Yong Li, Lei Yuan, Feiling Feng
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and emerging evidence suggests that the gut microbiota may play a role in its development and progression. In t...
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Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model mice Gut Microbes (IF 12.2) Pub Date : 2024-01-23 Yijing Chen, Yinhu Li, Yingying Fan, Shuai Chen, Li Chen, Yuewen Chen, Yu Chen
The gut microbiota (GM) and its metabolites affect the host nervous system and are involved in the pathogeneses of various neurological diseases. However, the specific GM alterations under pathogen...