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Risk factors, clinical features and treatment of Behçet's disease uveitis Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-09-19 Zhenyu Zhong, Guannan Su, Peizeng Yang
Behçet's disease is a systemic vasculitis frequently associated with intraocular inflammation. Recent findings identified independent clinical clusters in Behçet's disease, each involving distinct combinations of affected organs. Ocular Behçet's disease, mainly manifested as uveitis, is characterized as an independent cluster with a low likelihood of association with other system involvements, such
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Identification of novel biomarkers for retinopathy of prematurity in preterm infants by use of innovative technologies and artificial intelligence Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-08-21 Sandra Hoyek, Natasha F.S. da Cruz, Nimesh A. Patel, Hasenin Al-Khersan, Kenneth C. Fan, Audina M. Berrocal
Retinopathy of prematurity (ROP) is a leading cause of preventable vision loss in preterm infants. While appropriate screening is crucial for early identification and treatment of ROP, current screening guidelines remain limited by inter-examiner variability in screening modalities, absence of local protocol for ROP screening in some settings, a paucity of resources and an increased survival of younger
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Latest advances in white spot syndromes: New findings and interpretations Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-08-12 Maria Vittoria Cicinelli, Prithvi Ramtohul, Alessandro Marchese, Francesco Bandello, K. Bailey Freund, Elisabetta Miserocchi, Lee M. Jampol
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Optical coherence tomography angiography in diabetic retinopathy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-26 Nadia K. Waheed, Richard B. Rosen, Yali Jia, Marion R. Munk, David Huang, Amani Fawzi, Victor Chong, Quan Dong Nguyen, Yasir Sepah, Elizabeth Pearce
There remain many unanswered questions on how to assess and treat the pathology and complications that arise from diabetic retinopathy (DR). Optical coherence tomography angiography (OCTA) is a novel and non-invasive three-dimensional imaging method that can visualize capillaries in all retinal layers. Numerous studies have confirmed that OCTA can identify early evidence of microvascular changes and
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Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-15
Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ that has one of the highest metabolic rates body-wide and is constantly exposed to photooxidative damage and external stressors. Mitophagy is the selective autophagic degradation of mitochondria within lysosomes, and can be triggered by distinct stimuli such as mitochondrial damage or hypoxia. Here, we review
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Neville Osborne - Editor-in-Chief of Progress in Retinal and Eye Research for 40 years Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-19
Abstract not available
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Female carriers of X-linked inherited retinal diseases – Genetics, diagnosis, and potential therapies Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-03 Sena A. Gocuk, Jasleen K. Jolly, Thomas L. Edwards, Lauren N. Ayton
Inherited retinal diseases (IRDs) are a group of heterogeneous conditions that cause progressive vision loss, typically due to monogenic mutations. Female carriers of X-linked IRDs have a single copy of the disease-causing gene, and therefore, may exhibit variable clinical signs that vary from near normal retina to severe disease and vision loss. The relationships between individual genetic mutations
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Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO) Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-07-01 Mohammad Javed Ali
Primary acquired nasolacrimal duct obstruction, or PANDO, is a common adult lacrimal drainage disorder. The current treatment modality of dacryocystorhinostomy to bypass the obstructed nasolacrimal duct has excellent outcomes. However, the understanding of the disease etiopathogenesis needs to be revisited. There are not many studies that specifically assessed any hypothesis or ones that convincingly
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Posterior corneoscleral limbus: Architecture, stem cells, and clinical implications Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-06-29 Gary Hin-Fai Yam, Shaohua Pi, Yiqin Du, Jodhbir S. Mehta
The limbus is a transition from the cornea to conjunctiva and sclera. In human eyes, this thin strip has a rich variation of tissue structures and composition, typifying a change from scleral irregularity and opacity to corneal regularity and transparency; a variation from richly vascularized conjunctiva and sclera to avascular cornea; the neural passage and drainage of aqueous humor. The limbal stroma
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Familial normal tension glaucoma genetics Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-06-22 Austin R. Fox, John H. Fingert
Glaucoma is defined by characteristic optic nerve damage and corresponding visual field defects and is the leading cause of irreversible blindness in the world. Elevated intraocular pressure (IOP) is a strong risk factor for developing glaucoma. However, glaucoma can occur at any IOP. Normal tension glaucoma (NTG) arises with IOPs that are within what has been defined as a normal range, i.e., 21 mm
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The immune response in tubercular uveitis and its implications for treatment: From anti-tubercular treatment to host-directed therapies Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-05-25 Ikhwanuliman Putera, Benjamin Schrijver, Josianne C.E.M. ten Berge, Vishali Gupta, Rina La Distia Nora, Rupesh Agrawal, P. Martin van Hagen, Saskia M. Rombach, Willem A. Dik
Tubercular uveitis (TB-uveitis) remains a conundrum in the uveitis field, which is mainly related to the diverse clinical phenotypes of TB-uveitis. Moreover, it remains difficult to differentiate whether Mycobacterium tuberculosis (Mtb) is present in the ocular tissues, elicits a heightened immune response without Mtb invasion in ocular tissues, or even induces an anti-retinal autoimmune response.
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The multifunctional human ocular melanocortin system Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-05-20 Chieh-Lin (Stanley) Wu, Adrian V. Cioanca, Maria C. Gelmi, Li Wen, Nick Di Girolamo, Ling Zhu, Riccardo Natoli, R Max Conway, Constantinos Petsoglou, Martine J. Jager, Peter J. McCluskey, Michele C. Madigan
Immune privilege in the eye involves physical barriers, immune regulation and secreted proteins that together limit the damaging effects of intraocular immune responses and inflammation. The neuropeptide alpha-melanocyte stimulating hormone (α-MSH) normally circulates in the aqueous humour of the anterior chamber and the vitreous fluid, secreted by iris and ciliary epithelium, and retinal pigment epithelium
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Myocilin misfolding and glaucoma: A 20-year update Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-05-20 Emily G. Saccuzzo, Hannah A. Youngblood, Raquel L. Lieberman
Mutations in the gene MYOC account for approximately 5% of cases of primary open angle glaucoma (POAG). MYOC encodes for the protein myocilin, a multimeric secreted glycoprotein composed of N-terminal coiled-coil (CC) and leucine zipper (LZ) domains that are connected via a disordered linker to a 30 kDa olfactomedin (OLF) domain. More than 90% of glaucoma-causing mutations are localized to the OLF
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Elucidating glial responses to products of diabetes-associated systemic dyshomeostasis Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-04-05 Dolly Ann Padovani-Claudio, Carla J. Ramos, Megan E. Capozzi, John S. Penn
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. DR has non-proliferative stages, characterized in part by retinal neuroinflammation and ischemia, and proliferative stages, characterized by retinal angiogenesis. Several systemic factors, including poor glycemic control, hypertension, and hyperlipidemia, increase the risk of DR progression to vision-threatening stages
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From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-02-12 Grazyna Palczewska, Maciej Wojtkowski, Krzysztof Palczewski
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The novel role of lymphatic vessels in the pathogenesis of ocular diseases Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-02-08 Thomas Clahsen, Karina Hadrian, Maria Notara, Simona L. Schlereth, Antonia Howaldt, Verena Prokosch, Thomas Volatier, Deniz Hos, Falk Schroedl, Alexandra Kaser-Eichberger, Ludwig M. Heindl, Philipp Steven, Jacobus J. Bosch, Alexander Steinkasserer, Alexander C. Rokohl, Hanhan Liu, Mert Mestanoglu, Hamid Kashkar, Björn Schumacher, Friedemann Kiefer, Claus Cursiefen
Historically, the eye has been considered as an organ free of lymphatic vessels. In recent years, however, it became evident, that lymphatic vessels or lymphatic-like vessels contribute to several ocular pathologies at various peri- and intraocular locations. The aim of this review is to outline the pathogenetic role of ocular lymphatics, the respective molecular mechanisms and to discuss current and
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Amblyopia and the whole child Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-02-01
Amblyopia is a disorder of neurodevelopment that occurs when there is discordant binocular visual experience during the first years of life. While treatments are effective in improving visual acuity, there are significant individual differences in response to treatment that cannot be attributed solely to difference in adherence. In this considerable variability in response to treatment, we argue that
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Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-02-01
Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons, are well involved into retinal ganglion cell (RGC) degeneration in experimental glaucoma animal models generated by elevated IOP. In response to elevated IOP, mGluR I is first activated and Kir4.1 channels are subsequently
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Shedding light on myopia by studying complete congenital stationary night blindness Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-01-19 Christina Zeitz, Jérome E. Roger, Isabelle Audo, Christelle Michiels, Nuria Sánchez-Farías, Juliette Varin, Helen Frederiksen, Baptiste Wilmet, Jacques Callebert, Marie-Laure Gimenez, Nassima Bouzidi, Frederic Blond, Xavier Guilllonneau, Stéphane Fouquet, Thierry Léveillard, Vasily Smirnov, Ajoy Vincent, Elise Héon, José-Alain Sahel, Barbara Kloeckener-Gruissem, Serge Picaud
Myopia is the most common eye disorder, caused by heterogeneous genetic and environmental factors. Rare progressive and stationary inherited retinal disorders are often associated with high myopia. Genes implicated in myopia encode proteins involved in a variety of biological processes including eye morphogenesis, extracellular matrix organization, visual perception, circadian rhythms, and retinal
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The pre-Descemet's layer (Dua's layer, also known as the Dua-Fine layer and the pre-posterior limiting lamina layer): Discovery, characterisation, clinical and surgical applications, and the controversy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-01-14 Harminder S. Dua, Rui Freitas, Imran Mohammed, Darren S.J. Ting, Dalia G. Said
The pre-Descemet's layer/Dua's layer, also termed the Dua-Fine layer and the pre-posterior limiting lamina layer, lies anterior to the Descemet's membrane in the cornea, is 10 μm (range 6–16) thick, made predominantly of type I and some type VI collagen with abundant elastin, more than any other layer of the cornea. It has high tensile strength (bursting pressure up to 700 mm of Hg), is impervious
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The genetics and disease mechanisms of rhegmatogenous retinal detachment Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-01-06 Birgit M. Govers, Ramon A.C. van Huet, Susanne Roosing, Sander Keijser, Leonoor I. Los, Anneke I. den Hollander, B. Jeroen Klevering
Rhegmatogenous retinal detachment (RRD) is a sight threatening condition that warrants immediate surgical intervention. To date, 29 genes have been associated with monogenic disorders involving RRD. In addition, RRD can occur as a multifactorial disease through a combined effect of multiple genetic variants and non-genetic risk factors. In this review, we provide a comprehensive overview of the spectrum
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Endpoints for clinical trials in ophthalmology Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2023-01-02 Leopold Schmetterer, Hendrik Scholl, Gerhard Garhöfer, Lucas Janeschitz-Kriegl, Federico Corvi, SriniVas R. Sadda, Felipe A. Medeiros
With the identification of novel targets, the number of interventional clinical trials in ophthalmology has increased. Visual acuity has for a long time been considered the gold standard endpoint for clinical trials, but in the recent years it became evident that other endpoints are required for many indications including geographic atrophy and inherited retinal disease. In glaucoma the currently available
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Myopia: Histology, clinical features, and potential implications for the etiology of axial elongation Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-28 Jost B. Jonas, Rahul A. Jonas, Mukharram M. Bikbov, Ya Xing Wang, Songhomitra Panda-Jonas
Myopic axial elongation is associated with various non-pathological changes. These include a decrease in photoreceptor cell and retinal pigment epithelium (RPE) cell density and retinal layer thickness, mainly in the retro-equatorial to equatorial regions; choroidal and scleral thinning pronounced at the posterior pole and least marked at the ora serrata; and a shift in Bruch's membrane opening (BMO)
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Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-28 Yang Pan, Yingbin Fu, Paul N. Baird, Robyn H. Guymer, Taraprasad Das, Takeshi Iwata
Age-related macular degeneration (AMD) is the leading cause of severe irreversible central vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) have shown that the region at chromosome 10q26, where the age-related maculopathy susceptibility (ARMS2/LOC387715) and HtrA serine peptidase 1 (HTRA1) genes are located, represents one of the strongest associated loci for AMD
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10q26 – The enigma in age-related macular degeneration Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-10 David A. Merle, Merve Sen, Angela Armento, Chloe M. Stanton, Eric F. Thee, Magda A. Meester-Smoor, Markus Kaiser, Simon J. Clark, Caroline C.W. Klaver, Pearse A. Keane, Alan F. Wright, Michael Ehrmann, Marius Ueffing
Despite comprehensive research efforts over the last decades, the pathomechanisms of age-related macular degeneration (AMD) remain far from being understood. Large-scale genome wide association studies (GWAS) were able to provide a defined set of genetic aberrations which contribute to disease risk, with the strongest contributors mapping to distinct regions on chromosome 1 and 10. While the chromosome
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Cellular and subcellular optogenetic approaches towards neuroprotection and vision restoration Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-08 Edward H. Wood, Alexander Kreymerman, Tia Kowal, David Buickians, Yang Sun, Stephanie Muscat, Mark Mercola, Darius M. Moshfeghi, Jeffrey L. Goldberg
Optogenetics is defined as the combination of genetic and optical methods to induce or inhibit well-defined events in isolated cells, tissues, or animals. While optogenetics within ophthalmology has been primarily applied towards treating inherited retinal disease, there are a myriad of other applications that hold great promise for a variety of eye diseases including cellular regeneration, modulation
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Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-08 Jacob D. Bhoi, Manvi Goel, Christophe P. Ribelayga, Stuart C. Mangel
Circadian (24-h) clocks are cell-autonomous biological oscillators that orchestrate many aspects of our physiology on a daily basis. Numerous circadian rhythms in mammalian and non-mammalian retinas have been observed and the presence of an endogenous circadian clock has been demonstrated. However, how the clock and associated rhythms assemble into pathways that support and control retina function
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Secondary outcomes of lens and cataract surgery: More than just “best-corrected visual acuity” Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-05 Idan Hecht, Piotr Kanclerz, Raimo Tuuminen
Most studies evaluating cataract surgery focus on the primary outcome of early, central, best-corrected visual acuity. However, cataract surgery and intraocular lens (IOL) design have other secondary visual outcomes as well as impacts on various ocular tissues, the visual function, and quality of life. Some of these aspects are more difficult to quantify, or are historically neglected, but might be
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Regulation of lens water content: Effects on the physiological optics of the lens Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-12-05 Paul J. Donaldson, Yadi Chen, Rosica S. Petrova, Angus C. Grey, Julie C. Lim
The lens is an important determinant of overall vision quality whose refractive and transparent properties change throughout life. Alterations to the refractive properties of the lens contribute to the process of emmetropisation in early childhood, and then the gradual loss in lens power that occurs throughout adulthood. In parallel to these changes to lens refractive power, age-dependent increases
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Non-canonical Wnt signaling in the eye Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-25 Ruchi Shah, Cynthia Amador, Steven T. Chun, Sean Ghiam, Mehrnoosh Saghizadeh, Andrei A. Kramerov, Alexander V. Ljubimov
Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (β-catenin-dependent) or non-canonical (β-catenin-independent). Most previous studies in the eye have focused
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Cell identity changes in ocular surface Epithelia Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-20 Nick Di Girolamo, Mijeong Park
Corneal and conjunctival epithelia arise from a common ancestral ectoderm cell, then diverge into distinct lineages. The former develops into a multilayered stratified squamous epithelium, the latter into an expansive mucous membrane that stretches the eyelid margin to the cornea's outskirts. The limbus, which intersects these epithelia, is purported to harbor corneal stem cells. Intrinsic programs
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Retinal dystrophins and the retinopathy of Duchenne muscular dystrophy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-18 Mirella Telles Salgueiro Barboni, Anneka Joachimsthaler, Michel J. Roux, Zoltán Zsolt Nagy, Dora Fix Ventura, Alvaro Rendon, Jan Kremers, Cyrille Vaillend
Duchenne muscular dystrophy (DMD) is caused by X-linked inherited or de novo DMD gene mutations predominantly affecting males who develop early-onset muscle degeneration, severely affecting their quality of life and leading to reduced life expectancy. DMD patients may also develop proliferative retinopathy, cataract, ERG abnormalities, altered contrast sensitivity, color vision losses, and elevated
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Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-16 Won-Kyu Ju, Guy A. Perkins, Keun-Young Kim, Tonking Bastola, Woo-Young Choi, Soo-Ho Choi
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their axons, resulting in vision loss. Despite its high prevalence in individuals 60 years of age and older, the causing factors contributing to glaucoma progression are currently not well characterized. Intraocular pressure
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Advances in understanding the molecular structure of retinoschisin while questions remain of biological function Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-16 J Bernard Heymann, Camasamudram Vijayasarathy, Robert N. Fariss, Paul A. Sieving
Retinoschisin (RS1) is a secreted protein that is essential for maintaining integrity of the retina. Numerous mutations in RS1 cause X-linked retinoschisis (XLRS), a progressive degeneration of the retina that leads to vision loss in young males. A key manifestation of XLRS is the formation of cavities (cysts) in the retina and separation of the layers (schisis), disrupting synaptic transmission. There
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The OCT angular sign of Henle fiber layer (HFL) hyperreflectivity (ASHH) and the pathoanatomy of the HFL in macular disease Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-11-01 Prithvi Ramtohul, Diogo Cabral, SriniVas Sadda, K. Bailey Freund, David Sarraf
The Henle fiber layer (HFL) is comprised of bundles of unmyelinated photoreceptor axons intermingled with outer Müller cell processes. The photoreceptor axons extend from the cell bodies located in the outer nuclear layer and radially project toward the outer plexiform layer, the inner third of which includes the synaptic junctional complexes and the outer two-thirds of which includes the HFL. The
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Studies of the retinal microcirculation using human donor eyes and high-resolution clinical imaging: Insights gained to guide future research in diabetic retinopathy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-10-29 Chandrakumar Balaratnasingam, Dong An, Martin Hein, Paula Yu, Dao-Yi Yu
The microcirculation plays a key role in delivering oxygen to and removing metabolic wastes from energy-intensive retinal neurons. Microvascular changes are a hallmark feature of diabetic retinopathy (DR), a major cause of irreversible vision loss globally. Early investigators have performed landmark studies characterising the pathologic manifestations of DR. Previous works have collectively informed
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Congenital aniridia beyond black eyes: From phenotype and novel genetic mechanisms to innovative therapeutic approaches Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-10-22 Alejandra Daruich, Melinda Duncan, Matthieu P. Robert, Neil Lagali, Elena V. Semina, Daniel Aberdam, Stefano Ferrari, Vito Romano, Cyril Burin des Roziers, Rabia Benkortebi, Nathalie De Vergnes, Michel Polak, Frederic Chiambaretta, Ken K. Nischal, Francine Behar-Cohen, Sophie Valleix, Dominique Bremond-Gignac
Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively been shown to be associated with other developmental ocular abnormalities and systemic features making congenital aniridia a complex syndromic disorder rather than a simple isolated disease of the iris. Moreover, foveal hypoplasia is now recognized as a more frequent feature than complete iris hypoplasia
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Rhodopsin, light-sensor of vision Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-10-21 Klaus Peter Hofmann, Trevor D. Lamb
The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that exhibits remarkable physicochemical properties. This photopigment is extremely stable in the dark, yet its chromophore isomerises upon photon absorption with 70% efficiency, enabling the activation of its G-protein, transducin
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A paradigm shift in retinal detachment repair: The concept of integrity Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-10-14 Rajeev H. Muni, Wei Wei Lee, Aditya Bansal, Arun Ramachandran, Roxane J. Hillier
The management of rhegmatogenous retinal detachment has rapidly evolved over recent decades. A range of surgical techniques exist, all of which can achieve retinal reattachment in most cases. In recent years there have also been vast technical advances in retinal imaging that have introduced novel ways of visualizing and studying the retinal macro and microstructural anatomy following retinal detachment
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Homeostatic plasticity in the retina Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-10-13 Michael J. Fitzpatrick, Daniel Kerschensteiner
Vision begins in the retina, whose intricate neural circuits extract salient features of the environment from the light entering our eyes. Neurodegenerative diseases of the retina (e.g., inherited retinal degenerations, age-related macular degeneration, and glaucoma) impair vision and cause blindness in a growing number of people worldwide. Increasing evidence indicates that homeostatic plasticity
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In vivo application of base and prime editing to treat inherited retinal diseases Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-10-12 Dong Hyun Jo, Sangsu Bae, Hyongbum Henry Kim, Jin-Soo Kim, Jeong Hun Kim
Inherited retinal diseases (IRDs) are vision-threatening retinal disorders caused by pathogenic variants of genes related to visual functions. Genomic analyses in patients with IRDs have revealed pathogenic variants which affect vision. However, treatment options for IRDs are limited to nutritional supplements regardless of genetic variants or gene-targeting approaches based on antisense oligonucleotides
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Potential therapeutic targets for age-related macular degeneration: The nuclear option Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-10-08 Mayur Choudhary, Goldis Malek
The functions and activities of nuclear receptors, the largest family of transcription factors in the human genome, have classically focused on their ability to act as steroid and hormone sensors in endocrine organs. However, they are responsible for a diverse array of physiological functions, including cellular homeostasis and metabolism, during development and aging. Though the eye is not a traditional
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Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-09-24 David Križaj, Soenke Cordeiro, Olaf Strauß
Transient receptor potential (TRP) channels are a widely expressed family of 28 evolutionarily conserved cationic ion channels that operate as primary detectors of chemical and physical stimuli and secondary effectors of metabotropic and ionotropic receptors. In vertebrates, the channels are grouped into six related families: TRPC, TRPV, TRPM, TRPA, TRPML, and TRPP. As sensory transducers, TRP channels
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Therapy with voretigene neparvovec. How to measure success? Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-09-10 Krunoslav Stingl, Melanie Kempf, Ronja Jung, Friederike Kortüm, Giulia Righetti, Milda Reith, Spyridon Dimopoulos, Saskia Ott, Susanne Kohl, Katarina Stingl
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Heparan sulfate proteoglycans (HSPGs) of the ocular lens Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-09-06 Tayler F.L. Wishart, Frank J. Lovicu
Heparan sulfate proteoglycans (HSPGs) reside in most cells; on their surface, in the pericellular milieu and/or extracellular matrix. In the eye, HSPGs can orchestrate the activity of key signalling molecules found in the ocular environment that promote its development and homeostasis. To date, our understanding of the specific roles played by individual HSPG family members, and the heterogeneity of
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The role of the gut microbiome in eye diseases Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-09-06 Denise C. Zysset-Burri, Sophia Morandi, Elio L. Herzog, Lieselotte E. Berger, Martin S. Zinkernagel
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The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-08-31 Zhenzhen Liu, Shan Huang, Yingfeng Zheng, Tian Zhou, Leyi Hu, Lang Xiong, David Wan-cheng Li, Yizhi Liu
The crystalline lens is a transparent and refractive biconvex structure formed by lens epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading cause of blindness in the world. LECs are the principal cells of lens throughout human life, exhibiting different physiological properties and functions. During the embryonic stage, LECs proliferate and differentiate into
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Towards a better understanding of non-exudative choroidal and macular neovascularization Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-08-13 Riccardo Sacconi, Serena Fragiotta, David Sarraf, SriniVas R. Sadda, K. Bailey Freund, Mariacristina Parravano, Giulia Corradetti, Diogo Cabral, Vittorio Capuano, Alexandra Miere, Eliana Costanzo, Francesco Bandello, Eric Souied, Giuseppe Querques
Non-exudative macular and choroidal neovascularization (MNV and CNV) usually refers to the entity of treatment-naïve type 1 neovascularization in the absence of associated signs of exudation. Histopathological studies, dating back in the early 70s, identified the presence of non-exudative MNV, but the first clinical report of this finding was in the late 90s using indocyanine green angiography in eyes
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Quantitative approaches in multimodal fundus imaging: State of the art and future perspectives Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-08-04 Alessandro Arrigo, Emanuela Aragona, Maurizio Battaglia Parodi, Francesco Bandello
When it first appeared, multimodal fundus imaging revolutionized the diagnostic workup and provided extremely useful new insights into the pathogenesis of fundus diseases. The recent addition of quantitative approaches has further expanded the amount of information that can be obtained. In spite of the growing interest in advanced quantitative metrics, the scientific community has not reached a stable
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Non-vasogenic cystoid maculopathies Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-08-01 Alain Gaudric, Isabelle Audo, Catherine Vignal, Aude Couturier, Élise Boulanger-Scemama, Ramin Tadayoni, Salomon Yves Cohen
Besides cystoid macular edema due to a blood-retinal barrier breakdown, another type of macular cystoid spaces referred to as non-vasogenic cystoid maculopathies (NVCM) may be detected on optical coherence tomography but not on fluorescein angiography. Various causes may disrupt retinal cell cohesion or impair retinal pigment epithelium (RPE) and Müller cell functions in the maintenance of retinal
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Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-07-19 Mengliang Wu, Lisa J. Hill, Laura E. Downie, Holly R. Chinnery
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with their important roles in the maintenance of nerves in both homeostasis and inflammation. Using in vivo confocal microscopy in humans, and ex vivo immunostaining and fluorescent reporter mice to visualize corneal sensory nerves and immune cells, remarkable progress has been made to advance our understanding
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Bioengineering approaches for modelling retinal pathologies of the outer blood-retinal barrier Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-07-13 Blanca Molins, Marina Mesquida, Alfredo Adan
Alterations of the junctional complex of the outer blood-retinal barrier (oBRB), which is integrated by the close interaction of the retinal pigment epithelium, the Bruch's membrane, and the choriocapillaris, contribute to the loss of neuronal signalling and subsequent vision impairment in several retinal inflammatory disorders such as age-related macular degeneration and diabetic retinopathy. Reductionist
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RNA-targeting strategies as a platform for ocular gene therapy Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-07-13 Satheesh Kumar, Lewis E. Fry, Jiang-Hui Wang, Keith R. Martin, Alex W. Hewitt, Fred K. Chen, Guei-Sheung Liu
Genetic medicine is offering hope as new therapies are emerging for many previously untreatable diseases. The eye is at the forefront of these advances, as exemplified by the approval of Luxturna® by the United States Food and Drug Administration (US FDA) in 2017 for the treatment of one form of Leber Congenital Amaurosis (LCA), an inherited blindness. Luxturna® was also the first in vivo human gene
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Cell fate decisions, transcription factors and signaling during early retinal development Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-07-08 Raven Diacou, Prithviraj Nandigrami, Andras Fiser, Wei Liu, Ruth Ashery-Padan, Ales Cvekl
The development of the vertebrate eyes is a complex process starting from anterior-posterior and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye field. Symmetrical separation of the eye field at the anterior neural plate is followed by two symmetrical evaginations to generate a pair of optic vesicles. Next, reciprocal invagination of the optic vesicles with
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Zebrafish and inherited photoreceptor disease: Models and insights Prog. Retin. Eye. Res. (IF 17.8) Pub Date : 2022-07-08 Nicole C.L. Noel, W.Ted Allison, Ian M. MacDonald, Jennifer C. Hocking
Photoreceptor dysfunctions and degenerative diseases are significant causes of vision loss in patients, with few effective treatments available. Targeted interventions to prevent or reverse photoreceptor-related vision loss are not possible without a thorough understanding of the underlying mechanism leading to disease, which is exceedingly difficult to accomplish in the human system. Cone diseases