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AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2024-03-16 S. Yang, Y. Yin, Y. Sun, D. Ai, X. Xia, X. Xu, J. Song
Periodontal tissue destruction in periodontitis is a consequence of the host inflammatory response to periodontal pathogens, which could be aggravated in the presence of type 2 diabetes mellitus (T2DM). Accumulating evidence highlights the intricate involvement of macrophage-mediated inflammation in the pathogenesis of periodontitis under both normal and T2DM conditions. However, the underlying mechanism
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Neighborhood Deprivation and Changes in Oral Health in Older Age: A Longitudinal Population-Based Study J. Dent. Res. (IF 7.6) Pub Date : 2024-02-28 S.G. Ganbavale, E. Papachristou, J.C. Mathers, A.O. Papacosta, L.T. Lennon, P.H. Whincup, S.G. Wannamethee, S.E. Ramsay
The aim of this study was to examine the extent to which neighborhood-level socioeconomic factors (objective and perceived) are associated with poor oral health in older adults over time, independent of individual socioeconomic position. Data for this cross-sectional and longitudinal observation study came from a socially and geographically representative cohort of men aged 71 to 92 y in 2010–12 (
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IL-36 Regulates Neutrophil Chemotaxis and Bone Loss at the Oral Barrier J. Dent. Res. (IF 7.6) Pub Date : 2024-02-28 J. Liu, H. Meng, Y. Mao, L. Zhong, W. Pan, Q. Chen
Tissue-specific mechanisms regulate neutrophil immunity at the oral barrier, which plays a key role in periodontitis. Although it has been proposed that fibroblasts emit a powerful neutrophil chemotactic signal, how this chemotactic signal is driven has not been clear. The objective of this study was to investigate the site-specific regulatory mechanisms by which fibroblasts drive powerful neutrophil
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Injectable Tissue-Specific Hydrogel System for Pulp–Dentin Regeneration J. Dent. Res. (IF 7.6) Pub Date : 2024-02-27 Y. Han, J. Xu, H. Chopra, Z. Zhang, N. Dubey, W.L. Dissanayaka, J.E. Nör, M.C. Bottino
The quest for finding a suitable scaffold system that supports cell survival and function and, ultimately, the regeneration of the pulp–dentin complex remains challenging. Herein, we hypothesized that dental pulp stem cells (DPSCs) encapsulated in a collagen-based hydrogel with varying stiffness would regenerate functional dental pulp and dentin when concentrically injected into the tooth slices. Collagen
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Exploring Recent Decreases in First Molar Sealants among US Children J. Dent. Res. (IF 7.6) Pub Date : 2024-02-27 M. Lin, S. O. Griffin, C. H. Li, L. Wei, L. Espinoza, C. Y. Wang, G. Thornton-Evans
Analyses of National Health and Nutrition Examination Survey (NHANES) data suggested a significant decrease in sealant prevalence among children between 2011 to 2014 and 2015 to 2018. We explore whether this decrease could be associated with possible changes in 1) clinical sealant delivery, 2) dental materials (i.e., increased use of glass ionomer [GI] sealants resulting in an inability to detect sealant
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A Bilayer Method for Measuring Toughness and Strength of Dental Ceramics J. Dent. Res. (IF 7.6) Pub Date : 2024-02-27 H. Chai, J. Russ, S. Vardhaman, C.H. Lim, Y. Zhang
The ever-increasing usage of ceramic materials in restorative dentistry necessitates a simple and effective method to evaluate flexural strength σF and fracture toughness KC. We propose a novel method to determine these quantities using a bilayer specimen composed of a brittle plate adhesively bonded onto a transparent polycarbonate substrate. When this bilayer structure is placed under spherical indentation
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Single-Cell Transcriptomic Analysis of Salivary Gland Endothelial Cells J. Dent. Res. (IF 7.6) Pub Date : 2024-02-27 A.L. Altrieth, J. Kenney, D.A. Nelson, E.G. Suarez, V. Gellatly, S. Gabunia, M. Larsen
Vascular endothelial cells have important tissue-specific functions in fibrosis and regeneration. In the salivary gland, endothelial cells are required for proper development, but their roles within adult glands are largely unknown. To identify ligand–receptor interactions between endothelial cells and other cell types that may be important during fibrosis and regeneration, we used a reversible ductal
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The Essential Role of Proteoglycans and Glycosaminoglycans in Odontogenesis J. Dent. Res. (IF 7.6) Pub Date : 2024-02-26 J. Chen, T. Sun, B. Lin, B. Wu, J. Wu
Tooth development and regeneration are regulated through a complex signaling network. Previous studies have focused on the exploration of intracellular signaling regulatory networks, but the regulatory roles of extracellular networks have only been revealed recently. Proteoglycans, which are essential components of the extracellular matrix (ECM) and pivotal signaling molecules, are extensively involved
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Response to Letter, “Autophagy Plays a Crucial Role in Ameloblast Differentiation” J. Dent. Res. (IF 7.6) Pub Date : 2024-02-21 C. Iwaya, J. Iwata
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Biological Properties of 3D-Printed Zirconia Implants with p-Cell Structures J. Dent. Res. (IF 7.6) Pub Date : 2024-02-20 W. Qin, MH. Shen, N. Gan, BH. Xing, J. Sun, Z. Zhao, T. Jiao
Research on 3-dimensional (3D) printed porous zirconia-based dental implants is still in its infancy. This study aimed to evaluate the biological responses of novel zirconia implants with p-cell structures fabricated by 3D printing. The solid zirconia samples exhibited comparable density, 3-point flexural strength, and accelerated aging properties compared to specimens prepared previously by conventional
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Intelligently Quantifying the Entire Irregular Dental Structure J. Dent. Res. (IF 7.6) Pub Date : 2024-02-19 H. Liu, J. Duan, P. Zeng, M. Shi, J. Zeng, S. Chen, Z. Gong, Z. Chen, J. Qin, Z. Chen
Quantitative analysis of irregular anatomical structures is crucial in oral medicine, but clinicians often typically measure only several representative indicators within the structure as references. Deep learning semantic segmentation offers the potential for entire quantitative analysis. However, challenges persist, including segmentation difficulties due to unclear boundaries and acquiring measurement
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Effect of Periodontitis and Periodontal Therapy on Oral and Gut Microbiota J. Dent. Res. (IF 7.6) Pub Date : 2024-02-16 G. Baima, I. Ferrocino, V. Del Lupo, E. Colonna, V. Thumbigere-Math, G.P. Caviglia, I. Franciosa, G.M. Mariani, M. Romandini, D.G. Ribaldone, F. Romano, M. Aimetti
Mounting evidence indicates that periodontitis-related oral bacteria may contribute to gut microbial dysbiosis. This clinical study aimed to explore the oral–gut microbial signatures associated with periodontitis and to longitudinally evaluate the effect of periodontal treatment on the oral and gut microbial composition. Stool and saliva samples from generalized stage III/IV periodontitis patients
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Salivary Glands and Viral Pathogenesis J. Dent. Res. (IF 7.6) Pub Date : 2024-02-12 N. Atyeo, J.O. Maldonado, B.M. Warner, J.A. Chiorini
The oral cavity is an epidemiologically relevant route of viral transmission due to the shedding of viruses in saliva. With advancements in salivary diagnostics, an increasing number of viruses have been detected. However, the anatomic source of virus in saliva is still largely unknown. Some viruses have a well-established tropism for the salivary glands (SGs), and recent studies have emphasized the
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Murine IRF8 Mutation Offers New Insight into Osteoclast and Root Resorption J. Dent. Res. (IF 7.6) Pub Date : 2024-02-12 A. Das, S.K. Yesupatham, D. Allison, H. Tanwar, J. Gnanasekaran, B. Kear, X. Wang, S. Wang, C. Zachariadou, Y. Abbasi, M.K. Chung, K. Ozato, C. Liu, B.L. Foster, V. Thumbigere-Math
Interferon regulatory factor 8 (IRF8), a transcription factor expressed in immune cells, functions as a negative regulator of osteoclasts and helps maintain dental and skeletal homeostasis. Previously, we reported that a novel mutation in the IRF8 gene increases susceptibility to multiple idiopathic cervical root resorption (MICRR), a form of tooth root resorption mediated by increased osteoclast activity
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P. gingivalis–Induced TLR2 Interactome Analysis Reveals Association with PARP9 J. Dent. Res. (IF 7.6) Pub Date : 2024-02-12 K. Pandi, S. Angabo, H. Makkawi, H. Benyamini, S. Elgavish, G. Nussbaum
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium strongly associated with periodontal disease. Toll-like receptor 2 (TLR2) is indispensable for the host response to P. gingivalis, but P. gingivalis escapes from immune clearance via TLR2-dependent activation of phosphoinositide-3-kinase (PI3K). To probe the TLR2-dependent escape pathway of P. gingivalis, we analyzed the TLR2 interactome
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In Situ Photo-Crosslinkable Protein Bioadhesive for Bone Graft Fixation J. Dent. Res. (IF 7.6) Pub Date : 2024-02-06 J. Yun, I.H. Nam, H. Lee, Y.K. Jo, H. Lee, S.H. Jun, H.J. Cha
Bone grafting is a fundamental dental surgery procedure widely used for implant placement and periodontal disease management treatments. Despite its broad applications, vertical bone augmentation presents unique challenges, including the risk of graft displacement due to gravitational and masticatory forces. Traditional physical stabilization methods introduce additional complexities and risks, underscoring
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Gli1+ Periodontal Mesenchymal Stem Cells in Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2024-01-29 Y. Deng, Q. Li, K.K.H. Svoboda, L.A. Opperman, L.B. Ruest, X. Liu
Periodontal mesenchymal stem cells (MSCs) play a crucial role in maintaining periodontium homeostasis and in tissue repair. However, little is known about how periodontal MSCs in vivo respond under periodontal disease conditions, posing a challenge for periodontium tissue regeneration. In this study, Gli1 was used as a periodontal MSC marker and combined with a Gli1-cre ERT2 mouse model for lineage
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Sjögren’s Disease and Oral Health: A Genetic Instrumental Variable Analysis J. Dent. Res. (IF 7.6) Pub Date : 2024-01-29 S.L. Reckelkamm, Z. Alayash, B. Holtfreter, M. Nolde, S.E. Baumeister
Epidemiological studies have consistently shown that Sjögren’s disease (SjD) increases the risk of dental caries. Despite similar evidence indicating an elevated risk of periodontitis, SjD remains a disputed risk factor for this disease. The risk of bias in observational research is a major impediment to confirming this link. Within an instrumental variable framework, genetic variants associated with
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Composite Containing Calcium Phosphate Particles Functionalized with 10-MDP J. Dent. Res. (IF 7.6) Pub Date : 2024-01-29 R.A.A. da Silva, R.B. Trinca, H.S. Vilela, R.R. Braga
The phosphate ester monomer 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) is capable of bonding to hydroxyapatite and, for this reason, is a key component of several self-etch adhesives. In this study, dicalcium phosphate dihydrate particles (DCPD; CaHPO4.2H2O) were functionalized with 10-MDP and used to formulate an experimental composite with 50 vol% inorganic content (3:1 DCPD:silanated
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Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation J. Dent. Res. (IF 7.6) Pub Date : 2024-01-18 K. Amano, D. Okuzaki, Y. Kitaoka, S. Kato, M. Fujiwara, S. Tanaka, S. Iida
Neural crest cells (NCC) arise from the dorsal margin of the neural plate border and comprise a unique cell population that migrates to and creates the craniofacial region. Although factors including Shh, Fgf8, and bone morphogenetic proteins have been shown to regulate these biological events, the role of parathyroid hormone 1 receptor (Pth1r) has been less studied. We generated an NCC-specific mouse
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Copy Number Alterations Predict Development of OSCC from Oral Leukoplakia J. Dent. Res. (IF 7.6) Pub Date : 2024-01-13 X. Cai, J. Zhang, L. Li, L. Liu, M. Tang, X. Zhou, C. Peng, X. Li, X. Chen, M. Xu, H. Zhang, J. Wang, Y. Huang, T. Li
Oral leukoplakia (OLK) is a common type of potentially malignant disorder. Early identification of the malignancy potential leads to a better management of OLK and prediction of development of oral squamous cell carcinoma (OSCC). However, there has been no effective biomarker to assess the risk of malignancy in OLK. Genomic copy number alteration (CNA) is a complex chromosomal structural variation
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Casp11 Deficiency Alters Subgingival Microbiota and Attenuates Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2024-01-10 S.L. Fu, Y.Y. Qian, A.N. Dai, H.Y. Li, X.H. Jin, W.T. He, S. Kang, P.H. Ding
Periodontitis (PD) is the primary cause of tooth loss in adults. Porphyromonas gingivalis ( P.g), a keystone pathogen, has been identified as a crucial contributor to this process. Pyroptosis activation in PD is acknowledged, with accumulating evidence underscoring the crucial role of Caspase-11 (described as Caspase-4/5 in humans)–mediated noncanonical pyroptosis. However, the mechanism behind its
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Lacticaseibacillus rhamnosus GG Improves Periodontal Bone Repair via Gut–Blood Axis in Hyperlipidemia J. Dent. Res. (IF 7.6) Pub Date : 2024-01-10 Y. Huang, R. Ge, J. Qian, J. Lu, D. Qiao, R. Chen, H. Jiang, D. Cui, T. Zhang, N. Wang, S. He, M. Wang, F. Yan
Periodontal bone regeneration remains a clinical challenge, and hyperlipidemia can aggravate alveolar bone resorption. Probiotics have recently been reported to improve bone mass. We aimed to determine the role of Lacticaseibacillus rhamnosus GG (LGG) in periodontal bone regeneration improvement within the context of periodontitis with hyperlipidemia. A Sprague Dawley rat model for periodontitis, hyperlipidemia
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Impact of Periodontitis on the Leakage of Oral Bacteria to the Gut J. Dent. Res. (IF 7.6) Pub Date : 2024-01-09 E. Buetas, M. Jordán-López, A. López-Roldán, A. Mira, M. Carda-Diéguez
Colorectal cancer (CRC) and periodontitis have recently been related due to the higher incidence of CRC in periodontal patients and the involvement of periodontal pathogens in carcinogenesis, suggesting that leakage from the oral cavity to the gut occurs. However, the magnitude of this pass-through in healthy individuals is controversial, and the effect that periodontitis could play in it is understudied
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Dual Role of IGF2BP2 in Osteoimmunomodulation during Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2024-01-09 X.X. Ma, X.Y. Zhou, M.G. Feng, Y.T. Ji, F.F. Song, Q.C. Tang, Q. He, Y.F. Zhang
Periodontitis is a complex disease characterized by distinct inflammatory stages, with a peak of inflammation in the early phase and less prominent inflammation in the advanced phase. The insulin-like growth factor 2-binding proteins 2 (IGF2BP2) has recently been identified as a new m6A reader that protects m6A-modified messenger RNAs (mRNAs) from decay, thus participating in multiple biological processes
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Electrolyzed Saline Targets Biofilm Periodontal Pathogens In Vitro J. Dent. Res. (IF 7.6) Pub Date : 2024-01-08 N. Zayed, H. Munjaković, M.K. Aktan, K. Simoens, K. Bernaerts, N. Boon, A. Braem, F. Pamuk, M. Saghi, W. Van Holm, A. Fidler, R. Gašperšič, W. Teughels
Preventing the development and recurrence of periodontal diseases often includes antimicrobial mouthrinses to control the growth of the periodontal pathogens. Most antimicrobials are nonselective, targeting the symbiotic oral species as well as the dysbiosis-inducing ones. This affects the overall microbial composition and metabolic activity and consequently the host–microbe interactions, which can
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Intestinal Translocation of Live Porphyromonas gingivalis Drives Insulin Resistance J. Dent. Res. (IF 7.6) Pub Date : 2024-01-08 C. Niu, W. Lv, X. Zhu, Z. Dong, K. Yuan, Q. Jin, P. Zhang, P. Li, M. Mao, T. Dong, Z. Chen, J. Luo, L. Hou, C. Zhang, K. Hao, S. Chen, Z. Huang
Periodontitis has been emphasized as a risk factor of insulin resistance–related systemic diseases. Accumulating evidence has suggested a possible “oral–gut axis” linking oral infection and extraoral diseases, but it remains unclear whether periodontal pathogens can survive the barriers of the digestive tract and how they play their pathogenic roles. The present study established a periodontitis mouse
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Redefining Mucosal Inflammation with Spatial Genomics J. Dent. Res. (IF 7.6) Pub Date : 2024-01-03 A.J. Caetano, P.T. Sharpe
The human oral mucosa contains one of the most complex cellular systems that are essential for normal physiology and defense against a wide variety of local pathogens. Evolving techniques and experimental systems have helped refine our understanding of this complex cellular network. Current single-cell RNA sequencing methods can resolve subtle differences between cell types and states, thus providing
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Rapid Intrafibrillar Mineralization Strategy Enhances Adhesive-Dentin Interface. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-22 X Gao,Z Wang,H Yang,C Huang
Biomimetic mineralization of dentin collagen appears to be a promising strategy to optimize dentin bonding durability. However, traditional postbonding mineralization strategies based on Ca/P ion release still have some drawbacks, such as being time-consuming, having a spatiotemporal mismatch, and having limited intrafibrillar minerals. To tackle these problems, a prebonding rapid intrafibrillar mineralization
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ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates Amelogenesis. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-21 X Zhu,Z Ma,F Xie,J Wang
Histone methylation assumes a crucial role in the intricate process of enamel development. Our study has illuminated the substantial prevalence of H3K4me3 distribution, spanning from the cap stage to the late bell stage of dental germs. In order to delve into the role of H3K4me3 modification in amelogenesis and unravel the underlying mechanisms, we performed a conditional knockout of Ash2l, a core
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Single-Cell Transcriptomic Analysis of Dental Pulp and Periodontal Ligament Stem Cells. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-20 Y Yang,T Alves,M Z Miao,Y C Wu,G Li,J Lou,H Hasturk,T E Van Dyke,A Kantarci,D Wu
The regeneration of periodontal, periapical, and pulpal tissues is a complex process requiring the direct involvement of cells derived from pluripotent stem cells in the periodontal ligament and dental pulp. Dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) are spatially distinct with the potential to differentiate into similar functional and phenotypic cells. We aimed to
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Letter to the Editor, "Autophagy Plays a Crucial Role in Ameloblast Differentiation". J. Dent. Res. (IF 7.6) Pub Date : 2023-11-15 S Sukseree,R Gruber,E Tschachler,L Eckhart
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Endochondral Repair of Jawbone Defects Using Periosteal Cell Spheroids. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-15 J Zhu,S Zhang,S Jin,C Huang,B Shi,Z Chen,W Ji
Recapitulation of the natural healing process is receiving increasing recognition as a strategy to induce robust tissue regeneration. Endochondral ossification has been recognized as an essential reparative approach in natural jawbone defect healing. However, such an approach has been overlooked in the recent development of cell-based therapeutics for jawbone repair. Therefore, this study aimed to
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Sex-Related Effect of Aging in Gingival Gamma-Delta T Cells. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-15 V Tubero Euzebio Alves,M E C Bruno,S Mukherjee,L Wang,R J Danaher,L Su,M E Starr,O A Gonzalez
Aging affects the number and function of gamma-delta (γδ) T cells in a tissue-specific manner, modifying the risk for inflammatory disease. These aging-related γδT-cell variations in gingival tissues that could increase the risk for inflammation and periodontal disease remain unknown. Here we sought to identify quantitative and qualitative variations in gingival γδT cells associated with aging that
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Clinically Oriented CBCT Periapical Lesion Evaluation via 3D CNN Algorithm. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-15 W T Fu,Q K Zhu,N Li,Y Q Wang,S L Deng,H P Chen,J Shen,L Y Meng,Z Bian
Apical periodontitis (AP) is one of the most prevalent disorders in dentistry. However, it can be underdiagnosed in asymptomatic patients. In addition, the perioperative evaluation of 3-dimensional (3D) lesion volume is of great clinical relevance, but the required slice-by-slice manual delineation method is time- and labor-intensive. Here, for quickly and accurately detecting and segmenting periapical
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Systemic Metabolic Signatures of Oral Diseases. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-15 A Salminen,A M Määttä,P Mäntylä,J Leskelä,M Pietiäinen,K Buhlin,A L Suominen,S Paju,W Sattler,J Sinisalo,P J Pussinen
Systemic metabolic signatures of oral diseases have been rarely investigated, and prospective studies do not exist. We analyzed whether signs of current or past infectious/inflammatory oral diseases are associated with circulating metabolites. Two study populations were included: the population-based Health-2000 (n = 6,229) and Parogene (n = 452), a cohort of patients with an indication to coronary
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Sex as a Biological Variable in Oral Diseases: Evidence and Future Prospects. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-15 L Sangalli,L C Souza,A Letra,L Shaddox,E Ioannidou
The interest of the scientific community on sex and gender differences in health and disease has increased substantially over the past 25 to 30 y as a result of a long process of events and policies in the biomedical field. This is crucial as compelling evidence from human and animal model studies has demonstrated that sex and gender influence health, molecular and cellular processes, and response
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Enhanced Bonding to Caries-Affected Dentin Using an Isocyanate-Based Primer. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-10 K Tang,F Wang,S Q Dai,Z Y Yang,L Y Duan,M L Luo,F R Tay,L N Niu,W Zhou,J H Chen
Dental caries is the most common oral disease and the most common cause of resin restorations. In minimally invasive dentistry, the principle behind cavity preparation is to remove external caries-infected dentin (CID) and preserve internal caries-affected dentin (CAD) and sound dentin (SD). The cavity floor is mainly composed of CAD, but the poor bonding performance of CAD has become a widespread
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Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-10 B He,V Kram,T Furusawa,O Duverger,E Y Chu,R Nanduri,M Ishikawa,P Zhang,B A Amendt,J S Lee,M Bustin
Dental enamel formation is coordinated by ameloblast differentiation, production of enamel matrix proteins, and crystal growth. The factors regulating ameloblast differentiation are not fully understood. Here we show that the high mobility group N (HMGN) nucleosomal binding proteins modulate the rate of ameloblast differentiation and enamel formation. We found that HMGN1 and HMGN2 proteins are downregulated
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Preinterventional Third-Molar Assessment Using Robust Machine Learning. J. Dent. Res. (IF 7.6) Pub Date : 2023-11-09 J S Carvalho,M Lotz,L Rubi,S Unger,T Pfister,J M Buhmann,B Stadlinger
Machine learning (ML) models, especially deep neural networks, are increasingly being used for the analysis of medical images and as a supporting tool for clinical decision-making. In this study, we propose an artificial intelligence system to facilitate dental decision-making for the removal of mandibular third molars (M3M) based on 2-dimensional orthopantograms and the risk assessment of such a procedure
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Gestational Serum Retinol Deficiency Is Associated with Enamel Hypoplasia. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-29 S R Samuel,C W M Lai,M M Khan,M G Mathew,M S Kramer,C-Y S Hsu
Enamel hypoplasia (EH) is a prevalent developmental defect of teeth that can result from various insults, including prenatal nutrient deficiencies. This study aimed to evaluate the association between prenatal serum retinol deficiency and EH in the deciduous teeth of offspring at 2-y of age. A cohort of 1,450 pregnant women was enrolled, and their prenatal nutritional status was assessed between 12
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Triple Function of Amelogenin Peptide-Chitosan Hydrogel for Dentin Repair. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-26 J Cai,J Moradian-Oldak
Biomimetic strategies like peptide-guided collagen mineralization promise to enhance the effectiveness of dentin remineralization. We recently reported that rationally designed amelogenin-derived peptides P26 and P32 promoted apatite nucleation, mineralized collagen, and showed potential in enamel regrowth and dentin remineralization. To facilitate the clinical application of amelogenin-derived peptides
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Circulating Metabolites and Dental Traits: A Mendelian Randomization Study. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-21 Q Zheng,W Li,Y Zhang,X Liu,Y Fu,S Luo,X Deng,C Zeng
It is of great importance to uncover causal biomarkers to gain insight into the pathogenesis of oral diseases and identify novel treatment targets for prevention and treatment thereof. This study aimed to systematically evaluate the causal effects of hundreds of metabolites on 10 dental traits using a 2-sample Mendelian randomization (MR) approach. Genetic variants from genome-wide association studies
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Designing Calcium Silicate Cements with On-Demand Properties for Precision Endodontics. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-20 A Cahyanto,P Rath,T X Teo,S S Tong,R Malhotra,B N Cavalcanti,L Z Lim,K S Min,D Ho,W F Lu,V Rosa
Calcium silicate (C3S) cements are available in kits that do not account for patients' specific needs or clinicians' preferences regarding setting time, radiopacity, mechanical, and handling properties. Moreover, slight variations in powder components and liquid content affect cement's properties and bioactivity. Unfortunately, it is virtually impossible to optimize several cement properties simultaneously
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RvE1 Promotes Axin2+ Cell Regeneration and Reduces Bacterial Invasion. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-13 Y-C Wu,N Yu,C A Rivas,N Mehrnia,A Kantarci,T E Van Dyke
Vital pulp therapy and root canal therapy (RCT) are the dominant treatment for irreversible pulpitis. While the success rate of these procedures is favorable, they have some limitations. For instance, RCT leads to removing significant dentin in the coronal third of the tooth that increases root-fracture risk, which forces tooth removal. The ideal therapeutic goal is dental pulp regeneration, which
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miRNAs from Inflamed Gingiva Link Gene Signaling to Increased MET Expression. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-11 L Zheng,A Chopra,J Weiner,D Beule,H Dommisch,A S Schaefer
Several array-based microRNA (miRNA) expression studies independently showed increased expression of miRNAs hsa-miR-130a-3p, -142-3p, -144-3p, -144-5p, -223-3p, -17-5p, and -30e-5p in gingiva affected by periodontal inflammation. We aimed to determine direct target genes and signaling pathways regulated by these miRNAs to identify processes relevant to gingival inflammatory responses and tissue homeostasis
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Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-10 X Pan,Z Zhao,X Huang,X Cen
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with the cessation of matrix anabolism and aggravation of inflammation, which results in severe pain and impaired joint function. However, the mechanisms are not well understood. Circular RNAs (circRNAs) are reported to have various biological functions and participate in the development, diagnosis, prognosis, and treatment of
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Omics-Based Mathematical Modeling Unveils Pathogenesis of Periodontitis in an Experimental Murine Model. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-06 C Fujihara,K Murakami,S Magi,D Motooka,T Nantakeeratipat,A Canela,R J Tanaka,M Okada,S Murakami
Periodontitis is a multifactorial disease that progresses via dynamic interaction between bacterial and host-derived genetic factors. The recent trend of omics analyses has discovered many periodontitis-related risk factors. However, how much the individual factor affects the pathogenesis of periodontitis is still unknown. This article aims to identify multiple key factors related to the pathogenesis
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Occlusal Force Maintains Alveolar Bone Homeostasis via Type H Angiogenesis. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-03 Y Chen,Y Yin,M Luo,J Wu,A Chen,L Deng,L Xie,X Han
Physiologically, teeth and periodontal tissues are exposed to occlusal forces throughout their lifetime. Following occlusal unloading, unbalanced bone remodeling manifests as a net alveolar bone (AB) loss. This phenomenon is termed alveolar bone disuse osteoporosis (ABDO), the underlying mechanism of which remains unclear. Type H vessels, a novel capillary subtype tightly coupled with osteogenesis
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Quantitative Assessment of Systematic Bias: A Guide for Researchers. J. Dent. Res. (IF 7.6) Pub Date : 2023-10-03 J C Bond,M P Fox,L A Wise,B Heaton
Observational research provides valuable opportunities to advance oral health science but is limited by vulnerabilities to systematic bias, including unmeasured confounding, errors in variable measurement, or bias in the creation of study populations and/or analytic samples. The potential influence of systematic biases on observed results is often only briefly mentioned among the discussion of limitations
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Butyrate Inhibits Dendritic Cell Activation and Alleviates Periodontitis. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-29 L Wu,Z Luo,Y Chen,Z Yan,J Fu,Y Jiang,J Xu,Y Liu
Dendritic cells (DCs) can mediate inflammation-related bone resorption that is crucial in the development of periodontitis. Butyrate is a critical by-product of microbes with antibacterial and anti-inflammatory properties. Here, we found that butyrate inhibited the activation of lipopolysaccharide (LPS)-induced DCs and generation of inflammatory cytokines by DCs. Moreover, butyrate regulated glycolysis
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Force-Loaded Cementocytes Regulate Osteoclastogenesis via S1P/S1PR1/Rac1 Axis. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-21 H Wang,T Li,Y Jiang,S Chen,S Zou,L F Bonewald,P Duan
Orthodontically induced inflammatory root resorption (OIIRR) is the major iatrogenic complication of orthodontic treatment, seriously endangering tooth longevity and impairing masticatory function. Osteoclasts are thought to be the primary effector cells that initiate the pathological process of OIIRR; however, the cellular and molecular mechanisms responsible for OIIRR remain unclear. Our previous
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Biogeographical Impacts of Dental, Oral, and Craniofacial Microbial Reservoirs. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-20 Q T Easter,B Fernandes Matuck,B M Warner,K M Byrd
The human mouth, or oral cavity, is at the crossroads of our external and internal environments, and it is increasingly evident that local colonization of dental, oral, and craniofacial (DOC) tissues and cells by bacteria and viruses may also have systemic effects across myriad diseases and disorders. Better understanding of this phenomenon will require a holistic understanding of host-microbial interactions
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The Pathogenesis of COVID-19-Related Taste Disorder and Treatments. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-20 J Wang,R Liu,H Ma,W Zhang
COVID-19, mainly manifested as acute respiratory distress syndrome, has afflicted millions of people worldwide since 2019. Taste dysfunction is a common early-stage symptom of COVID-19 infection that burdens patients for weeks or even permanently in some cases. Owing to its subjectivity and complexity, the mechanism of taste disorder is poorly studied. Previous studies have reported that the COVID-19
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A Remineralizing and Antibacterial Coating for Arresting Caries. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-12 D Lu,F Li,C Zhao,Y Ye,X Zhang,P Yang,X Zhang
Dental caries is a dynamic disease induced by the unbalance between demineralization of dental hard tissues caused by biofilm and remineralization of them; however, although various effective remineralization methods have been well documented, it is a challenge to reestablish the balance by enhancing remineralization alone while ignoring the antibacterial therapy. Therefore, the integration of remineralizing
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Increased STAT3 Activation in Periodontitis Drives Inflammatory Bone Loss. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-12 M Arce,M Rodriguez-Peña,J Espinoza-Arrue,R A Godoy,M Reyes,T Kajikawa,T Greenwell-Wild,G Hajishengallis,L Abusleme,N Moutsopoulos,N Dutzan
Periodontitis is one of the most prevalent human inflammatory diseases. It is characterized by periodontal tissue destruction, progressively driven by the host response. In this regard, cytokines associated with tissue destruction, such as interleukin (IL)-6 and IL-23, use a common signaling pathway mediated by STAT3. This transcription factor is also needed for IL-17A production, a key mediator in
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Determinants of Microscale pH in In Situ-Grown Dental Biofilms. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-12 M F Kristensen,M B Lund,A Schramm,E Frandsen Lau,S Schlafer
Dental biofilm pH is the most important determinant of virulence for the development of caries lesions. Confocal microscopy-based pH ratiometry allows monitoring biofilm pH with high spatial resolution. Experiments performed on simplified biofilm models under static conditions identified steep pH gradients as well as localized acidogenic foci that promote enamel demineralization. The present work used
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Antibacterial Activity of a Lysin LysP53 against Streptococcus mutans. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-12 X Zhao,C Li,H Yang,H Wei,Y Li
Dental caries is a common disease affecting quality of life globally. In the present study, we found that a bacteriophage lysin LysP53 against Acinetobacter baumannii possesses selective activity on Streptococcus mutans, the main etiological agent of dental caries, even in low pH caries microenvironments, whereas only minor LysP53 activity was detected against Streptococcus sanguinis, Streptococcus
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Osteoprotective Role of the Mir338 Cluster Ablation during Periodontitis. J. Dent. Res. (IF 7.6) Pub Date : 2023-09-08 H S Zhang,C X Jiang,Y T Ji,Y F Zhang,Z Chen,Z G Cao,H Liu
Periodontitis is a chronic inflammatory disease that compromises the integrity of the supporting tissues of the teeth and leads to the loss of the alveolar bone. The Mir338 cluster has been proven to be a potential target for the treatment of osteoporosis and is also enriched in gingival tissues with periodontitis; however, its role in periodontitis remains unknown. Here, we aimed to use periodontitis
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Analysis of Hepatitis D Virus in Minor Salivary Gland of Sjögren's Disease. J. Dent. Res. (IF 7.6) Pub Date : 2023-08-14 M C Hesterman,S V Furrer,B S Fallon,M L Weller
Hepatitis delta virus (HDV) has been detected in the minor salivary gland (MSG) tissue of Sjögren's disease (SjD) patients in the absence of a hepatitis B virus (HBV) coinfection. Previous research has shown that HDV antigen (HDAg) expression can trigger an SjD-like phenotype in vivo, demonstrating a potential cause-and-effect relationship. We hypothesize that if HDV plays a role in the development