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Social Epigenomics: Conceptualizations and Considerations for Oral Health. J. Dent. Res. (IF 8.924) Pub Date : 2022-08-03 N Gomaa
Advances in high-throughput technologies and the generation of multiomics, such as genomic, epigenomic, transcriptomic, and metabolomic data, are paving the way for the biological risk stratification and prediction of oral diseases. When integrated with electronic health records, survey, census, and/or epidemiologic data, multiomics are anticipated to facilitate data-driven precision oral health, or
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Bio-based Non-estrogenic Dimethacrylate Dental Composite from Cloves. J. Dent. Res. (IF 8.924) Pub Date : 2022-08-03 Y Sun,L Sun,L Hong,J Li,S Tang,C Zhao
Bisphenol A (BPA), as an endocrine disruptor derived from petroleum-based chemicals, has been prohibited by several regulatory agencies for use in a wide variety of consumer products. For the sake of reducing human exposure to BPA derivatives and in the context of sustainability, it is far-reaching to develop high-performance and low-toxic materials from bountiful biomass sources. The objective of
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TLR9 Mediates Periodontal Aging by Fostering Senescence and Inflammaging. J. Dent. Res. (IF 8.924) Pub Date : 2022-08-02 E Albuquerque-Souza,K E Crump,K Rattanaprukskul,Y Li,B Shelling,X Xia-Juan,M Jiang,S E Sahingur
TLR9 is a critical nucleic acid sensing receptor in mediating periodontitis and periodontitis-associated comorbidities. Emerging evidence implicates TLR9 as a key sensor during aging, although its participation in periodontal aging is unexplored. Here, we investigated whether TLR9-mediated host responses can promote key hallmarks of aging, inflammaging, and senescence, in the course of periodontitis
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FaceBase: A Community-Driven Hub for Data-Intensive Research J. Dent. Res. (IF 8.924) Pub Date : 2022-07-31 R.E. Schuler, A. Bugacov, J.G. Hacia, T.V. Ho, J. Iwata, L. Pearlman, B.D. Samuels, C. Williams, Z. Zhao, C. Kesselman, Y. Chai
The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial Research of the National Institutes of Health, was established in 2009 with the recognition that dental and craniofacial research are increasingly data-intensive disciplines. Data sharing is critical for the validation and reproducibility of results as well as to enable reuse of data. In service of these goals, data
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HIF-2α Inhibits Ameloblast Differentiation via Hey2 in Tooth Development J. Dent. Res. (IF 8.924) Pub Date : 2022-07-31 S. Kimura, N. Takeshita, T. Oyanagi, D. Seki, W. Jiang, K. Hidaka, S. Fukumoto, I. Takahashi, T. Takano-Yamamoto
Enamel is the highly mineralized outer layer of teeth; the cells responsible for enamel formation are ameloblasts. Local hypoxia and hypoxia inducible factor (HIF) in embryonic tissues are important to promote normal organogenesis. However, hypoxic state in tooth germs and the roles of HIF in ameloblast differentiation have not been understood. The aim of this study is to clarify the role of HIF in
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Federated Learning in Dentistry: Chances and Challenges J. Dent. Res. (IF 8.924) Pub Date : 2022-07-31 R. Rischke, L. Schneider, K. Müller, W. Samek, F. Schwendicke, J. Krois
Building performant and robust artificial intelligence (AI)–based applications for dentistry requires large and high-quality data sets, which usually reside in distributed data silos from multiple sources (e.g., different clinical institutes). Collaborative efforts are limited as privacy constraints forbid direct sharing across the borders of these data silos. Federated learning is a scalable and privacy-preserving
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IADR President Address J. Dent. Res. (IF 8.924) Pub Date : 2022-07-27 B. O’Connell
Dear friends, colleagues, and supporters of IADR—dia dhaoibh agus fáilte. It is a great honor for me to speak to you as the incoming president of IADR and I hope that in the coming year we will have the opportunity to meet, discuss, and enjoy the research of our fellow members once again. I want to especially thank our President Eric Reynolds for his leadership, wisdom, and kindness over the past year
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Preprocedural Mouthwashes for Reduction of SARS-CoV-2 Viral Load and Infectivity J. Dent. Res. (IF 8.924) Pub Date : 2022-07-27 F. Cieplik, N.S. Jakubovics
Following the emergence of SARS-CoV-2 and the outbreak of the COVID-19 pandemic in early 2020, specific infection control regimens were introduced to protect health care workers and patients in dental practices (Meng et al. 2020; Peng et al. 2020). Among other measures, the use of antiseptic mouthwashes prior to dental procedures has been specifically recommended to temporarily reduce intraoral viral
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The Global Need for Easy and Valid Assessment Tools for Orofacial Pain J. Dent. Res. (IF 8.924) Pub Date : 2022-07-26 F. Lobbezoo, G. Aarab, F.P. Kapos, A.F. Dayo, Z. Huang, M. Koutris, M.A. Peres, M. Thymi, B. Häggman-Henrikson
The World Health Organization recently adopted a historic resolution (WHA74.5) on the urgent need for global oral health improvement. This resolution is particularly relevant in the perspective of the high prevalence of untreated oral diseases. However, one important aspect has been mentioned only in passing, namely that poor oral health often leads to orofacial pain, which is the most common reason
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Public Valuation of Direct Restorations: A Discrete Choice Experiment J. Dent. Res. (IF 8.924) Pub Date : 2022-07-25 O. Bailey, S. Stone, L. Ternent, C.R. Vernazza
Direct posterior dental restorations are commonly provided following management of dental caries. Amalgam use has been phased down and the feasibility of a phase-out by 2030 is being explored. Alternative direct restorative materials differ in their outcomes and provision. This research aimed to elicit the UK population’s preferences for different attributes of restorations and their willingness to
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HIF-1α Stabilization Boosts Pulp Regeneration by Modulating Cell Metabolism J. Dent. Res. (IF 8.924) Pub Date : 2022-07-07 Y. Han, M. Koohi-Moghadam, Q. Chen, L. Zhang, H. Chopra, J. Zhang, W.L. Dissanayaka
Stem cell–based therapeutics is a promising strategy in dental pulp regeneration. However, low cell viability after transplantation in vivo due to the ischemic microenvironment is still a critical challenge for future clinical application. With the aim of improving postimplantation cell survival and pulp tissue regeneration, stem cells from human exfoliated deciduous teeth (SHED) were preconditioned
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Gli1+-PDL Cells Contribute to Alveolar Bone Homeostasis and Regeneration J. Dent. Res. (IF 8.924) Pub Date : 2022-07-04 N. Shalehin, Y. Seki, H. Takebe, S. Fujii, T. Mizoguchi, H. Nakamura, N. Yoshiba, K. Yoshiba, M. Iijima, T. Shimo, K. Irie, A. Hosoya
The periodontal ligament (PDL) contains mesenchymal stem cells (MSCs) that can differentiate into osteoblasts, cementoblasts, and fibroblasts. Nevertheless, the distribution and characteristics of these cells remain uncertain. Gli1, an essential hedgehog signaling transcription factor, functions in undifferentiated cells during embryogenesis. Therefore, in the present study, the differentiation ability
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Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation J. Dent. Res. (IF 8.924) Pub Date : 2022-07-04 G. Hajishengallis, T. Chavakis
Neutrophils are abundant, short-lived myeloid cells that are readily recruitable to sites of inflammation, where they serve as first-line defense against infection and other types of insult to the host. In recent years, there has been increased understanding on the involvement of neutrophils in chronic inflammatory diseases, where they may act as direct effectors of destructive inflammation. However
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Spatiotemporal MicroRNA-Gene Expression Network Related to Orofacial Clefts J. Dent. Res. (IF 8.924) Pub Date : 2022-06-30 F. Yan, L.M. Simon, A. Suzuki, C. Iwaya, P. Jia, J. Iwata, Z. Zhao
Craniofacial structures change dynamically in morphology during development through the coordinated regulation of various cellular molecules. However, it remains unclear how these complex mechanisms are regulated in a spatiotemporal manner. Here we applied natural cubic splines to model gene and microRNA (miRNA) expression from embryonic day (E) 10.5 to E14.5 in the proximal and distal regions of the
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Periodontitis and COVID-19: Biological Mechanisms and Meta-analyses of Epidemiological Evidence J. Dent. Res. (IF 8.924) Pub Date : 2022-06-30 G. Baima, C. Marruganti, M. Sanz, M. Aimetti, M. Romandini
Since the beginning of 2020, the entire global health care system has been severely challenged by the outbreak of coronavirus 2019 disease (COVID-19). Robust evidence has demonstrated a more severe course of COVID-19 in the presence of several comorbidities, such as cardiovascular diseases, diabetes mellitus, and obesity. Here, we critically appraise the recent research discoveries linking periodontitis
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Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes J. Dent. Res. (IF 8.924) Pub Date : 2022-06-30 Y. Zhou, D.W. McNeil, S. Haworth, T. Dudding, J.M. Chernus, C. Liu, D. Liu, C.D. Wright, J. Brumbaugh, C.L. Randall, R.J. Weyant, R.J. Crout, B. Foxman, S. Reis, N.J. Timpson, M.L. Marazita, J.R. Shaffer
Dental care–related fear and anxiety (DFA) is prevalent, affects oral health care utilization, and is related to poor oral health and decreased quality of life. In addition to learned and cultural factors, genetics is hypothesized to contribute to DFA. Therefore, we performed a genome-wide association study to identify genetic variants contributing to DFA. Adult and adolescent participants were from
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Deep Learning–Based Prediction of the 3D Postorthodontic Facial Changes J. Dent. Res. (IF 8.924) Pub Date : 2022-06-30 Y.S. Park, J.H. Choi, Y. Kim, S.H. Choi, J.H. Lee, K.H. Kim, C.J. Chung
With the increase of the adult orthodontic population, there is a need for an accurate and evidence-based prediction of the posttreatment face in 3 dimensions (3D). The objectives of this study are 1) to develop a 3D postorthodontic face prediction method based on a deep learning network using the patient-specific factors and orthodontic treatment conditions and 2) to validate the accuracy and clinical
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Cetylpyridinium Chloride Mouthwash to Reduce Shedding of Infectious SARS-CoV-2: A Double-Blind Randomized Clinical Trial J. Dent. Res. (IF 8.924) Pub Date : 2022-06-21 A. Alemany, D. Perez-Zsolt, D. Raïch-Regué, J. Muñoz-Basagoiti, D. Ouchi, C. Laporte-Villar, B. Baro, N. Henríquez, N. Prat, M. Ochoa Gianinetto, M. Viaplana Gutiérrez, M. Garcia Sánchez-Paniagua, N. Larrosa Henríquez, J. Moreno Vicente, J. Ara, M.A. Rodriguez-Arias, J. Puig, I. Blanco, C. Casañ Lopez, Á. Hernández, A.E. Bordoy, C. Esteban Redondo, V. González Soler, M. Giménez, V. Blanc, R. León,
The airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via respiratory fluids and droplets suggests that mouthwashes containing substances with virucidal activity can help reduce viral spread. We conducted a multicenter, double-blind, placebo-controlled, randomized trial to assess the virucidal activity of cetylpyridinium chloride (CPC) mouthwashes. Outpatients who
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Nanomechanical and Nonlinear Optical Properties of Glycated Dental Collagen J. Dent. Res. (IF 8.924) Pub Date : 2022-06-19 D. Haluszka, S. Aminmansour, P. Tóth, S. Aminmansour, M. Kellermayer
Nonenzymatic glycation is a multistep, slow reaction between reducing sugars and free amino groups of long-lived proteins, which affects the structural and mechanical properties of collagen-rich tissues via accumulation of advanced glycation end products (AGEs). Dental collagen is exposed to glycation as part of the natural aging process. However, in case of chronically high blood glucose, the process
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Matrix Vesicle–Mediated Mineralization and Potential Applications J. Dent. Res. (IF 8.924) Pub Date : 2022-06-19 T. Iwayama, P. Bhongsatiern, M. Takedachi, S. Murakami
Hard tissues, including the bones and teeth, are a fundamental part of the body, and their formation and homeostasis are critically regulated by matrix vesicle–mediated mineralization. Matrix vesicles have been studied for 50 y since they were first observed using electron microscopy. However, research progress has been hampered by various technical barriers. Recently, there have been great advancements
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Towards Trustworthy AI in Dentistry J. Dent. Res. (IF 8.924) Pub Date : 2022-06-23 J. Ma, L. Schneider, S. Lapuschkin, R. Achtibat, M. Duchrau, J. Krois, F. Schwendicke, W. Samek
Medical and dental artificial intelligence (AI) require the trust of both users and recipients of the AI to enhance implementation, acceptability, reach, and maintenance. Standardization is one strategy to generate such trust, with quality standards pushing for improvements in AI and reliable quality in a number of attributes. In the present brief review, we summarize ongoing activities from research
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Assembly of Ultralong Hydroxyapatite Nanowires into Enamel-like Materials J. Dent. Res. (IF 8.924) Pub Date : 2022-06-16 Q.Q. Wang, L.P. Wu, S. Zhang, Y. Tao, Y.Z. Li, Q.L. Zhou, S.L. Zheng, C.Y. Cao, Z. Zhou, Q.L. Li
To develop dental restorative materials with enamel-like structures, ultralong hydroxyapatite (HA) nanowires were synthesized by a hydrothermal method, followed by functionalization with 3-methacryloxypropyltrimethoxysilane (KH-570). The mixture of HA nanowires, KH-570, and light initiator was stirred and centrifuged. The precipitate was vacuum filtered to remove excessive KH-570 and then pressured
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Chronic Pain–Related Jaw Muscle Motor Load and Sensory Processing J. Dent. Res. (IF 8.924) Pub Date : 2022-06-16 J.C. Nickel, Y.M. Gonzalez, Y. Wu, Y. Liu, H. Liu, L.R. Iwasaki
Chronic pain associated with temporomandibular disorders (TMDs) may reflect muscle mechanoreceptor afferent barrage and dysregulated sensory processing. This observational study tested for associations between Characteristic Pain Intensity (CPI), physical symptoms (Patient Health Questionnaire–15 [PHQ-15]), and cumulative jaw muscle motor load (mV*s). In accordance with institutional review board oversight
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Vitronectin-Derived Peptide Promotes Reparative Dentin Formation J. Dent. Res. (IF 8.924) Pub Date : 2022-06-16 C. Park, M. Song, S.Y. Kim, B.M. Min
Exposed dental pulp can maintain its vitality through a pulp-capping procedure with biocompatible materials, followed by reparative dentin formation. Our previous study demonstrated that a vitronectin-derived peptide (VnP-16) promotes osteoblast differentiation and concomitantly restrains osteoclast differentiation and resorptive function. In this study, we aimed to demonstrate that VnP-16 promotes
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Neuroinflammation: A Distal Consequence of Periodontitis J. Dent. Res. (IF 8.924) Pub Date : 2022-06-16 X. Li, M. Kiprowska, T. Kansara, P. Kansara, P. Li
Periodontitis, a chronic, inflammatory disease, induces systemic inflammation and contributes to the development of neurodegenerative diseases. The precise etiology of the most common neurodegenerative disorders, such as sporadic Alzheimer’s, Parkinson’s diseases and multiple sclerosis (AD, PD, and MS, respectively), remains to be revealed. Chronic neuroinflammation is a well-recognized component of
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Retention of Intrafibrillar Minerals Improves Resin–Dentin Bond Durability J. Dent. Res. (IF 8.924) Pub Date : 2022-06-16 T. Shan, L. Huang, F.R. Tay, L. Gu
The concept of extrafibrillar demineralization involves selective removal of apatite crystallites from the extrafibrillar spaces of mineralized dentin without disturbing the intrafibrillar minerals within collagen. This helps avoiding activation of endogenous proteases and enables air-drying of partially demineralized dentin without causing collapse of completely demineralized collagen matrix that
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Multicompartmental Scaffolds for Coordinated Periodontal Tissue Engineering J. Dent. Res. (IF 8.924) Pub Date : 2022-06-10 Y. Yao, J.E. Raymond, F. Kauffmann, S. Maekawa, J.V. Sugai, J. Lahann, W.V. Giannobile
Successful periodontal repair and regeneration requires the coordinated responses from soft and hard tissues as well as the soft tissue–to–bone interfaces. Inspired by the hierarchical structure of native periodontal tissues, tissue engineering technology provides unique opportunities to coordinate multiple cell types into scaffolds that mimic the natural periodontal structure in vitro. In this study
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Dentistry and Interoperability J. Dent. Res. (IF 8.924) Pub Date : 2022-06-10 N.M.R. Rajkumar, M.R. Muzoora, S. Thun
Information has become the vital commodity of exchange in recent decades. Medicine is no exception; the importance of patient information in the digital form has been recognized by organizations and health care facilities. Almost all patient information, including medical history, radiographs, and feedback, can be digitally recorded synchronously and asynchronously. Nevertheless, patient information
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ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling J. Dent. Res. (IF 8.924) Pub Date : 2022-06-10 X. Liu, J. Zhao, H. Jiang, H. Li, Y. Feng, J. Ke, X. Long
Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease without effective intervention strategies. Previous research implied that alpha-kinase 1 (ALPK1) is involved in the inflammatory responses of gout, a chronic arthritis. Herein, we found the main distribution of ALPK1 in a proliferative layer of condylar cartilage and marrow cavity of subchondral bone, as well as a
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Strain Measurement within an Intact Swine Periodontal Ligament J. Dent. Res. (IF 8.924) Pub Date : 2022-06-10 K.P. Houg, A.M. Camarillo, M.R. Doschak, P.W. Major, T. Popowics, C.R. Dennison, D.L. Romanyk
The periodontal ligament (PDL) provides support, proprioception, nutrition, and protection within the tooth–PDL–bone complex (TPBC). While understanding the mechanical behavior of the PDL is critical, current research has inferred PDL mechanics from finite element models, from experimental measures on complete TPBCs, or through direct measurement of isolated PDL sections. Here, transducers are used
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Exploring Ductility in Dental Ceramics J. Dent. Res. (IF 8.924) Pub Date : 2022-06-10 L.M.M. Alves, C.S. Rodrigues, S. Vardhaman, C. Saunders, J.M. Schneider, B.R. Lawn, Y. Zhang
Two damage regimes—“brittle” and “ductile”—have been identified in the literature on ceramic grinding, machining, grit blasting, and wear. In the brittle regime, the damage mechanism is essentially crack formation, while in the ductile region, it is quasiplasticity. Onset of the brittle mode poses the greater threat to strength, so it becomes important to understand the mechanics of ductile–brittle
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New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies J. Dent. Res. (IF 8.924) Pub Date : 2022-06-10 J. Nguyen, P.S. Saffari, A.S. Pollack, S. Vennam, X. Gong, R.B. West, J.R. Pollack
Ameloblastoma (AB) is an odontogenic tumor that arises from ameloblast-lineage cells. Although relatively uncommon and rarely metastatic, AB tumors are locally invasive and destructive to the jawbone and surrounding structures. Standard-of-care surgical resection often leads to disfigurement, and many tumors will locally recur, necessitating increasingly challenging surgeries. Recent genomic studies
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The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development J. Dent. Res. (IF 8.924) Pub Date : 2022-06-09 K. Nagasaki, M.B. Chavez, A. Nagasaki, J.M. Taylor, M.H. Tan, M. Ma, E. Ralston, M.E. Thew, D.-G. Kim, M.J. Somerman, B.L. Foster
Bone sialoprotein (gene: Ibsp; protein: BSP) is a multifunctional extracellular matrix protein present in bone, cementum, and dentin. Accumulating evidence supports BSP as a key regulator of mineralized tissue formation via evolutionarily conserved functional domains, including a C-terminal integrin-binding Arg-Gly-Asp (RGD) domain implicated in extracellular matrix–cell signaling. Ablation of Ibsp
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Benchmarking Deep Learning Models for Tooth Structure Segmentation J. Dent. Res. (IF 8.924) Pub Date : 2022-06-09 L. Schneider, L. Arsiwala-Scheppach, J. Krois, H. Meyer-Lueckel, K.K. Bressem, S.M. Niehues, F. Schwendicke
A wide range of deep learning (DL) architectures with varying depths are available, with developers usually choosing one or a few of them for their specific task in a nonsystematic way. Benchmarking (i.e., the systematic comparison of state-of-the art architectures on a specific task) may provide guidance in the model development process and may allow developers to make better decisions. However, comprehensive
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Systemic Multimorbidity Clusters in People with Periodontitis J. Dent. Res. (IF 8.924) Pub Date : 2022-06-09 H. Larvin, J. Kang, V.R. Aggarwal, S. Pavitt, J. Wu
This study aimed to identify systemic multimorbidity clusters in people with periodontitis via a novel artificial intelligence–based network analysis and to explore the effect of associated factors. This study utilized cross-sectional data of 3,736 participants across 3 cycles of the National Health and Nutrition Examination Survey (2009 to 2014). Periodontal examination was carried out by trained
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Evidence of Decrease in the Prevalence of Dental Caries in New Zealand J. Dent. Res. (IF 8.924) Pub Date : 2022-06-08 R.H. Brown
Evidence of a substantial decrease in dental caries in New Zealand schoolchildren is available from a number of surveys extending over a period of 30 years; the decrease has been particularly apparent over the past five years. Fluoridation of public water supplies and the widespread use of fluoride toothpastes are considered to be having a major influence on caries prevalence. Coinciding with this
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AADOCR: Science First and Collective, Joyful Effervescence J. Dent. Res. (IF 8.924) Pub Date : 2022-06-08 J.A. Weintraub
Esteemed leaders, distinguished guests, members, and friends.
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Single-Cell Transcriptomic Atlas of Gingival Mucosa in Type 2 Diabetes J. Dent. Res. (IF 8.924) Pub Date : 2022-06-02 Q. Wang, W. Lin, X. Zhou, K. Lei, R. Xu, X. Zhang, Q. Xiong, R. Sheng, W. Song, W. Liu, Q. Wang, Q. Yuan
The oral gingival barrier is a constantly stimulated and dynamic environment where homeostasis is often disrupted, resulting in inflammatory periodontal diseases. Type 2 diabetes (T2D) has been reported to be associated with gingival barrier dysfunction, but the effect and underlying mechanism are inconclusive. Herein, we performed single-cell RNA sequencing (scRNA-seq) of gingiva from leptin receptor-deficient
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Dental Research Data Availability and Quality According to the FAIR Principles J. Dent. Res. (IF 8.924) Pub Date : 2022-06-02 S.E. Uribe, A. Sofi-Mahmudi, E. Raittio, I. Maldupa, B. Vilne
According to the FAIR principles, data produced by scientific research should be findable, accessible, interoperable, and reusable—for instance, to be used in machine learning algorithms. However, to date, there is no estimate of the quantity or quality of dental research data evaluated via the FAIR principles. We aimed to determine the availability of open data in dental research and to assess compliance
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Noma: A Neglected Area for Research J. Dent. Res. (IF 8.924) Pub Date : 2022-05-27 K.U.E. Ogbureke
Noma, a debilitating and destructive orofacial gangrene, remains endemic in the poor countries of sub-Saharan Africa and other noma hotbeds across the globe, mainly in countries characterized as underdeveloped economies with significant impoverished populations. Noma mostly affects children and infants. This is in spite of the universally held notion that noma is a preventable disease. Indeed, the
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RUNX2 Regulates Osteoblast Differentiation via the BMP4 Signaling Pathway J. Dent. Res. (IF 8.924) Pub Date : 2022-05-26 D. Liu, C. Zhang, Y. Liu, J. Li, Y. Wang, S. Zheng
RUNX2 is a master osteogenic transcription factor, and mutations in RUNX2 cause the inherited skeletal disorder cleidocranial dysplasia (CCD). Studies have revealed that RUNX2 is not only a downstream target of the bone morphogenetic protein (BMP) pathway but can also regulate the expression of BMPs. However, the underlying mechanism of the regulation of BMPs by RUNX2 remains unknown. In this project
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Dissecting B/Plasma Cells in Periodontitis at Single-Cell/Bulk Resolution J. Dent. Res. (IF 8.924) Pub Date : 2022-05-26 L. Liu, Y. Chen, L. Wang, F. Yang, X. Li, S. Luo, L. Yang, T. Wang, D. Song, D. Huang
In recent decades, our understanding of periodontitis has evolved from that based on a gross/histologic level to one on a cellular/molecular level. Previous landscape studies have explored molecular subtyping, diagnosis, and gingival tissue cell decomposition in periodontitis, and meaningful results have been obtained at a transcriptomic level. However, current periodontitis transcriptomic studies
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Finding Knowledge to Improve Oral Health for All. J. Dent. Res. (IF 8.924) Pub Date : 2022-05-25 B A Dye,J Albino
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Translating Science into Improved Health for All J. Dent. Res. (IF 8.924) Pub Date : 2022-05-25 L.K. McCauley, M. Robinson, R.N. D’Souza
Our world is at a turning point with biological and social pathogens wreaking havoc at the same time that science and technology are exploding with new discoveries. It is a pivotal time for the new report Oral Health in America: Advances and Challenges to be released and a pivotal time for our profession to take action and lead. The art, science, and practice of dentistry is very different from 20
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Pathways between Social Capital and Oral Health from Childhood to Adolescence J. Dent. Res. (IF 8.924) Pub Date : 2022-05-20 J.K. Knorst, B. Brondani, M.V. Vettore, D. Hesse, F.M. Mendes, T.M. Ardenghi
This study aimed to evaluate the theoretical pathways by which social capital can influence dental caries and oral health–related quality of life (OHRQoL) of children over time. This 10-y prospective cohort started in 2010 with a sample of 639 preschoolers aged 1 to 5 y from the southern Brazil. Community and individual social capital were assessed at baseline through the presence of formal institutions
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Root Canal Treatment Survival Analysis in National Dental PBRN Practices J. Dent. Res. (IF 8.924) Pub Date : 2022-05-12 T. Thyvalikakath, M. LaPradd, Z. Siddiqui, W.D. Duncan, G. Eckert, J.K. Medam, D.B. Rindal, M. Jurkovich, G.H. Gilbert, National Dental PBRN Collaborative Group
Few studies have examined the longevity of endodontically treated teeth in nonacademic clinical settings where most of the population receives its care. This study aimed to quantify the longevity of teeth treated endodontically in general dentistry practices and test the hypothesis that longevity significantly differed by the patient’s age, gender, dental insurance, geographic region, and placement
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Waterline Disinfectants Reduce Dental Bioaerosols: A Multitracer Validation J. Dent. Res. (IF 8.924) Pub Date : 2022-05-01 J.R. Allison, C. Dowson, N.S. Jakubovics, C. Nile, J. Durham, R. Holliday
Oral microbes are dispersed during dental treatment and reduction methods have been proposed, but dental unit waterline (DUWL) disinfectants have received little attention; specifically, the effect on viruses has not been studied. This study aims to 1) investigate the effect of DUWL disinfectants on viral dispersion in dental bioaerosols and 2) establish a dual-tracer system using live bacteriophage
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Areca Nut and Oral Cancer: Evidence from Studies Conducted in Humans J. Dent. Res. (IF 8.924) Pub Date : 2022-04-22 S. Warnakulasuriya, T.H.H. Chen
Areca nut chewing is one of the major risk factors for oral cancer, with large-magnitude risks reported in studies comparing betel quid chewers and never users, and it has been evaluated as a group 1 carcinogen by the International Agency for Research on Cancer. Data from a high-quality meta-analysis examining risk estimates are presented in summary form with additional information from more recent
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Dual Functions of MDP Monomer with De- and Remineralizing Ability J. Dent. Res. (IF 8.924) Pub Date : 2022-04-21 H. Zheng, Y. Shi, L. Bi, Z. Zhang, Z. Zhou, C. Shao, D. Cui, X. Cheng, R. Tang, H. Pan, Z. Wu, B. Fu
Methacryloyloxydecyl dihydrogen phosphate (MDP) has been speculated to induce mineralization, but there has been no convincing evidence of its ability to induce intrafibrillar mineralization. Polymers play a critical role in biomimetic mineralization as stabilizers/inducers of amorphous precursors. Hence, MDP-induced biomimetic mineralization without polymer additives has not been fully verified or
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Microrobotics for Precision Biofilm Diagnostics and Treatment J. Dent. Res. (IF 8.924) Pub Date : 2022-04-21 A. Babeer, M.J. Oh, Z. Ren, Y. Liu, F. Marques, A. Poly, B. Karabucak, E. Steager, H. Koo
Advances in small-scale robotics and nanotechnology are providing previously unimagined opportunities for new diagnostic and therapeutic approaches with high precision, control, and efficiency. We designed microrobots for tetherless biofilm treatment and retrieval using iron oxide nanoparticles (NPs) with dual catalytic-magnetic functionality as building blocks. We show 2 distinct microrobotic platforms
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Histopathology-Based Diagnosis of Oral Squamous Cell Carcinoma Using Deep Learning J. Dent. Res. (IF 8.924) Pub Date : 2022-04-21 S.Y. Yang, S.H. Li, J.L. Liu, X.Q. Sun, Y.Y. Cen, R.Y. Ren, S.C. Ying, Y. Chen, Z.H. Zhao, W. Liao
Oral squamous cell carcinoma (OSCC) is prevalent around the world and is associated with poor prognosis. OSCC is typically diagnosed from tissue biopsy sections by pathologists who rely on their empirical experience. Deep learning models may improve the accuracy and speed of image classification, thus reducing human error and workload. Here we developed a custom-made deep learning model to assist pathologists
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Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3 J. Dent. Res. (IF 8.924) Pub Date : 2022-04-15 A. Rakian, R. Rakian, A.E. Shay, C.N. Serhan, T.E. Van Dyke
Periodontal disease is a significant public health problem worldwide. Excess unresolved chronic inflammation destroys the periodontal tissues that surround and support the teeth, and efforts to control inflammation by removal of bacterial deposits on the teeth have limited long-term impact. Likewise, procedures aimed at regeneration of the periodontal tissues have shown limited success. Recent advances
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Oral Health and Academic Achievement of Children in Low-Income Families J. Dent. Res. (IF 8.924) Pub Date : 2022-04-15 G.L. Wehby
Low-income children have higher rates of unmet oral health needs. Prior research suggests that poor oral health is associated with lower academic performance but uses cross-sectional and mostly parent-reported measures. This study examined the association between oral health during the first 5 y of life and subsequent academic achievement for low-income children. Birth certificates of children born
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Interpretable AI Explores Effective Components of CAD/CAM Resin Composites J. Dent. Res. (IF 8.924) Pub Date : 2022-04-15 H. Li, T. Sakai, A. Tanaka, M. Ogura, C. Lee, S. Yamaguchi, S. Imazato
High flexural strength of computer-aided manufacturing resin composite blocks (CAD/CAM RCBs) are required in clinical scenarios. However, the conventional in vitro approach of modifying materials’ composition by trial and error was not efficient to explore the effective components that contribute to the flexural strength. Machine learning (ML) is a powerful tool to achieve the above goals. Therefore
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COVID-19 Pandemic Impact on US Childhood Caries and Potential Mitigation J. Dent. Res. (IF 8.924) Pub Date : 2022-04-15 C. Scherrer, S. Naavaal, M. Lin, S.O. Griffin
Non-Hispanic Black (NHB) and Hispanic and low-income US children have a higher prevalence of untreated caries than their higher-income and non-Hispanic White (NHW) counterparts. Due to the COVID-19 pandemic, many dental offices and school sealant programs closed beginning March 2020. We examine the effect of reduced access to restorative care and sealants on the oral health of children from low-income
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Advances in Head and Neck Cancer Pain J. Dent. Res. (IF 8.924) Pub Date : 2022-04-13 Y. Ye, D.D. Jensen, C.T. Viet, H.L. Pan, W.M. Campana, M. Amit, M.D. Boada
Head and neck cancer (HNC) affects over 890,000 people annually worldwide and has a mortality rate of 50%. Aside from poor survival, HNC pain impairs eating, drinking, and talking in patients, severely reducing quality of life. Different pain phenotype in patients (allodynia, hyperalgesia, and spontaneous pain) results from a combination of anatomical, histopathological, and molecular differences between
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Visible Occlusal Plaque Index Predicting Caries Lesion Activity J. Dent. Res. (IF 8.924) Pub Date : 2022-04-12 J.C. Carvalho, H.D. Mestrinho, N.R. Aimée, A. Bakhshandeh, V. Qvist
This study was undertaken to appraise the predictive validity of the Visible Occlusal Plaque Index (VOPI) in assessing occlusal caries lesion activity in adolescents. A total of 618 adolescents aged 10 to 15 y were examined at the beginning of the trial and 511 (82.7%) at the 2-y follow-up. Adolescents and parents answered questionnaires about demographics, oral health behavior, and family sociodemographic
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Odontogenic Differentiation Induced by TGF-β1 Binding Peptide–Modified Bioglass J. Dent. Res. (IF 8.924) Pub Date : 2022-04-12 J. Wu, S. Mao, L. Xu, D. Qiu, S. Wang, Y. Dong
Emerging evidence suggests that growth factors are crucial in regenerative endodontic therapy. To achieve the desired effects, the systematic administration of supraphysiologic concentrations of exogenous growth factors is commonly performed, but this is usually associated with high costs, technique, and safety issues. Here, we describe a novel biomaterial that can manipulate endogenous growth factors
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Transdisciplinary Research: The Virtuous Cycle of Research Translation to Improve Oral Health. J. Dent. Res. (IF 8.924) Pub Date : 2022-04-11 E C Reynolds
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CGRP and Shh Mediate the Dental Pulp Cell Response to Neuron Stimulation J. Dent. Res. (IF 8.924) Pub Date : 2022-04-11 E.R. Moore, B. Michot, O. Erdogan, A. Ba, J.L. Gibbs, Y. Yang
Dental pain is a persistent, detrimental public health issue that requires a better understanding of the mechanisms of tooth pain and inflammation in order to develop more effective treatments. Calcitonin gene-related peptide (CGRP) and dental pulp cells are promising candidates for mediating tooth pain and generating reparative dental tissues, respectively, but their behavior in the context of pulpitis