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Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse. J. Dent. Res. (IF 7.6) Pub Date : 2023-07-14 P Nag,T Inubushi,J I Sasaki,T Murotani,S Kusano,Y Nakanishi,Y Shiraishi,H Kurosaka,S Imazato,Y Yamaguchi,T Yamashiro
Teeth consist of 3 mineralized tissues: enamel, dentin, and cementum. Tooth malformation, the most common craniofacial anomaly, arises from complex genetic and environmental factors affecting enamel structure, size, shape, and tooth eruption. Hyaluronic acid (HA), a primary extracellular matrix component, contributes to structural and physiological functions in periodontal tissue. Transmembrane protein
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Fibulin-1 Regulates Initiation of Successional Dental Lamina. J. Dent. Res. (IF 7.6) Pub Date : 2023-07-14 G Li,Q Li,Z Shen,X Lin,X Li,J Wang,B Zhao,Y Feng,L Feng,W Guo,L Hu,J Wang,C Zhang,Z Fan,S Wang,X Wu
In humans, teeth are replaced only once, and the successional dental lamina (SDL) of the permanent tooth is maintained in a quiescent state until adolescence. Recently, we showed that biomechanical stress generated by the rapid growth of the deciduous tooth inhibits SDL development via integrin β1-RUNX2 signaling at embryonic day 60 (E60) in miniature pigs. However, the mechanism by which RUNX2 regulates
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Endothelial Insulin Resistance Exacerbates Experimental Periodontitis. J. Dent. Res. (IF 7.6) Pub Date : 2023-07-14 T Zeze,T Shinjo,K Sato,Y Nishimura,M Imagawa,S Chen,A-K Ahmed,M Iwashita,A Yamashita,T Fukuda,T Sanui,K Park,G L King,F Nishimura
Epidemiological studies suggest that the severity of periodontitis is higher in people with diabetes than in healthy individuals. Insulin resistance might play a crucial role in the pathogenesis of multiple diabetic complications and is reportedly induced in the gingiva of rodents with type 2 diabetes; however, the molecular mechanisms underlying the pathogenesis of diabetes-related periodontitis remain
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Fatigue Threshold R-Curves for Dental Lithium Disilicate Glass-Ceramics. J. Dent. Res. (IF 7.6) Pub Date : 2023-07-14 J Lubauer,U Lohbauer,R Belli
Chemical and mechanical fatigue degradation in ceramic materials is generally inconspicuous yet ubiquitous, to the effect that clinical fractures still consist of the main cause of failure in all-ceramic restorations. Implications of this span wide, from a reduced survival prognosis for the affected teeth, including more frequent and increasingly invasive procedural interventions, to the financial
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An Appreciation of a Giant in Orofacial Sciences Research-John Greenspan. J. Dent. Res. (IF 7.6) Pub Date : 2023-07-14 S J Challacombe,O D Klein
Professor John S. Greenspan died on March 31, 2023. He was a renowned and accomplished academic, dentist/scientist, pathologist, and administrator who made sustained and significant international impacts on numerous fields over half a century. John was arguably best known for his work with his wife, Dr. Deborah Greenspan, on the oral aspects of AIDS and the role of viruses in oral epithelial and salivary
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Co-occurrence of Periodontitis and Diabetes-Related Complications. J. Dent. Res. (IF 7.6) Pub Date : 2023-07-14 F V Bitencourt,G G Nascimento,S A Costa,A Andersen,A Sandbæk,F R M Leite
Periodontitis is a common finding among people with diabetes mellitus (DM) and has been cited as a DM complication. Whether and how periodontitis relates to other diabetes-related complications has yet to be explored. This study aims to examine the clustering of periodontitis with other diabetes-related complications and explore pathways linking diabetes-related complications with common risk factors
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The Oral Microbiome and Cross-Kingdom Interactions during Pregnancy. J. Dent. Res. (IF 7.6) Pub Date : 2023-07-11 C Gilbert Klaczko,N Alkhars,Y Zeng,M E Klaczko,A L Gill,D T Kopycka-Kedzierawski,T A Jusko,M B Sohn,J Xiao,S R Gill
Pregnancy initiates a temporary transition in the maternal physiological state, with a shift in the oral microbiome and a potential increase in frequency of oral diseases. The risk of oral disease is higher among populations of Hispanic and Black women and those with lower socioeconomic status (low SES), demonstrating a need for intervention within these high-risk populations. To further our understanding
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A Tribute to Dr. William D. McHugh (May 8, 1929-October 6, 2022). J. Dent. Res. (IF 7.6) Pub Date : 2023-07-07 E Eliav,K E Black
The 12th president of the American Association for Dental Research (now the American Association for Dental, Oral, and Craniofacial Research) and the 65th president of the International Association for Dental Research, Dr. William D. McHugh was one of the longest-serving directors of the Eastman Institute for Oral Health in Rochester, New York. His exceptional leadership was evident throughout his
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Aging and Oral Health: Biological and Sociobehavioral Perspectives. J. Dent. Res. (IF 7.6) Pub Date : 2023-07-01 A P Colombo,B Wu
As the life expectancy and growth of the aging population increase globally, efforts to promote healthy longevity become more important. Holistic policy guidelines and actions have been designed to advocate and fortify healthy aging at multiple levels. Oral health, a fundamental contributor of overall health and well-being, forms a core part of the noncommunicable disease agenda within the sustainable
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Ten-Year Performance of Posterior 6-mm Implants with Single-Tooth Restorations: A Randomized Controlled Trial. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-30 P Sahrmann,N Naenni,R E Jung,C H F Hämmerle,T Attin,P R Schmidlin
The aim of the study was to compare the clinical and radiographic outcomes of short dental implants (6-mm test group, TG) to longer implants (10-mm control group, CG) with single crown restorations after 10 y of loading. Patients requiring single-tooth replacement in the posterior jaws were randomly assigned to TG or CG. Implants were loaded with screw-retained single crowns after a healing period
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PRRX1+MSCs Enhance Mandibular Regeneration during Distraction Osteogenesis. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-30 W D Jiang,P Q Zhu,T Zhang,F C Liao,P P Jiang,N Zhou,X D Wang,X P Huang
Bone defect (BD) caused by trauma, infection, congenital defects, or neoplasia is a major cause of physical limitation. Distraction osteogenesis (DO) is a highly effective procedure for bone regeneration, while the concrete mechanism remains unknown. In this study, canine DO and BD models of the mandible were established. The results of micro-computed tomography and histological staining revealed that
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Does Periodontitis Affect the Association of Biological Aging with Mortality? J. Dent. Res. (IF 7.6) Pub Date : 2023-06-26 Y Liu,S Xu,Q Cai,Y Chen,P Zhu,M Du,A Visser,A Li
The prevalence of periodontitis is increasing with the aging of the global population. Periodontitis has been suggested to accelerate aging and increase mortality. The present nationwide prospective cohort study aimed to determine whether periodontitis could modify the association of biological aging with all-cause and cause-specific mortality in middle-aged and older adults. Participants ≥40 y of
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Inhibition of Mertk Signaling Enhances Bone Healing after Tooth Extraction. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-22 A M Decker,M Matsumoto,J T Decker,A Roh,N Inohara,J Sugai,K Martin,R Taichman,D Kaigler,L D Shea,G Núñez
Regeneration of alveolar bone is an essential step in restoring healthy function following tooth extraction. Growth of new bone in the healing extraction socket can be variable and often unpredictable when systemic comorbidities are present, leading to the need for additional therapeutic targets to accelerate the regenerative process. One such target is the TAM family (Tyro3, Axl, Mertk) of receptor
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Predicting Dental Caries in Young Children in Primary Health Care Settings. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-16 M Fontana,G J Eckert,B P Katz,M A Keels,B T Levy,S M Levy,A R Kemper,E Yanca,R Jackson,J Warren,J L Kolker,J M Daly,S Kelly,J Talbert,P McKnight
Young children need increased access to dental prevention and care. Targeting high caries risk children first helps meet this need. The objective of this study was to develop a parent-completed, easy-to-score, short, accurate caries risk tool for screening in primary health care settings to identify children at increased risk for cavities. A longitudinal, prospective, multisite, cohort study enrolled
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Salivary Cortisol and Anxiety in Canadian Dentists over 1 Year of COVID-19. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-15 R J Kolbe,S A Madathil,L M Marin,R Seth,N Faraj,P J Allison,C Quiñonez,M Glogauer,W L Siqueira,M F Siqueira
The dental profession has endured unprecedented disruption amid COVID-19. Novel stressors have included a high risk of occupational exposure to COVID-19, financial losses, and stricter infection prevention and control requirements. The present study investigated the longitudinal impact of COVID-19 on the stress and anxiety levels of a cohort of Canadian dentists (N = 222) between September 2020 and
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Rethinking Oral Health in Aging: Ecosocial Theory and Intersectionality. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-14 L Slack-Smith,T Ng,M E Macdonald,A Durey
Poor oral health affects the health and well-being of older adults in many ways. Despite years of international research investigating poor oral health among older adults, it has remained a largely unresolved problem. The aim of this article is to explore the combination of 2 key frameworks, ecosocial theory and intersectionality, to guide our exploration and understanding of oral health and aging
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Edentulism Predicts Cognitive Decline in the US Health and Retirement Cohort Study. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-14 J A Jones,K Moss,T L Finlayson,J S Preisser,J A Weintraub
This longitudinal cohort study examines if 1) cognitive decline varies by birth cohort, adjusting for covariates, and 2) edentulism and nonuse of dental care predict 10-y cognitive decline (2008-2018). The Health and Retirement Study (HRS) features a representative sample of US adults over age 50. Eligibility criteria included having cognitive interview data available and responding to the question
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Dental Anomalies and Genetic Polymorphisms as Predictors of Maxillofacial Growth in Individuals Born with Cleft Lip and Palate. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-12 R H W Lacerda,A R Vieira
Cleft lip and palate have a complex inheritance, and 90% of its variation in the population is due to genetic contributors. The impact of surgical procedures on maxillofacial growth is well known, but the interference of intrinsic factors in these growth outcomes is not elucidated. The present study aimed to analyze genetic polymorphisms and frequency of dental anomalies as predictors of maxillofacial
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Disaggregated Nano-Hydroxyapatite (DnHAP) with Inhibitory Effects on Biofilms and Demineralization. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-07 Y Huang,Q Han,X Peng,B Ren,J Li,X Zhou,M Li,L Cheng
Nano-hydroxyapatite (nHAP) is considered a biocompatible agent that promotes the remineralization of dental hard tissue; however, its antibacterial efficacy is under scientific discussion. Therefore, this investigation aimed to specify the inhibitory effects of disaggregated nano-hydroxyapatite (DnHAP) on regrown biofilms and demineralization. Regrown biofilm models of single-species (Streptococcus
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The Challenges of the Present Rooted in the Past. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-07 A R Vieira
The speech of the AADOCR President-Elect Alexandre R. Vieira given at the opening ceremony of the 52nd Annual Meeting and Exhibition in Portland, March 15, 2023.
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Effect of Tooth Loss on Cognitive Function among Older Adults in Singapore. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-06 S Kiuchi,U Cooray,J Aida,K Osaka,A Chan,R Malhotra,M A Peres
Evidence suggests a longitudinal association between tooth loss and cognitive function. However, the temporality of this association is not well understood. We investigated the effect of several emulated tooth loss prevention scenarios on cognitive function. We used data from 3 waves (baseline: 2009, second wave: 2011-2012, and third wave: 2015) of the Panel on Health and Ageing of Singaporean Elderly
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Oral Biofilm Cryotherapy as a Novel Ecological Modulation Approach. J. Dent. Res. (IF 7.6) Pub Date : 2023-06-06 N Zayed,J Ghesquière,N H N Kamarudin,K Bernaerts,N Boon,A Braem,W Van Holm,W Teughels
Oral cryotherapy is used in dentistry as a safe, simple, and low-cost treatment for a variety of oral lesions. It is well known for its ability to aid in the healing process. However, its effect on oral biofilms is unknown. As a result, the purpose of this study was to assess the effects of cryotherapy on in vitro oral biofilms. In vitro multispecies oral biofilms were grown on the surface of hydroxyapatite
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Autophagy Plays a Crucial Role in Ameloblast Differentiation. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-30 C Iwaya,A Suzuki,J Shim,C G Ambrose,J Iwata
Tooth enamel is generated by ameloblasts. Any failure in amelogenesis results in defects in the enamel, a condition known as amelogenesis imperfecta. Here, we report that mice with deficient autophagy in epithelial-derived tissues (K14-Cre;Atg7F/F and K14-Cre;Atg3F/F conditional knockout mice) exhibit amelogenesis imperfecta. Micro-computed tomography imaging confirmed that enamel density and thickness
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Factors of Dental Care Utilization in Foreign-Born Older Chinese Americans. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-30 W Mao,B Wu,W Yang,I Chi
Good oral health is essential for healthy aging. Regular dental care utilization is instrumental to good oral health. Older immigrants tend to experience poorer oral health and less dental care use as compared with their native-born counterparts in the host country. Older immigrants are particularly vulnerable to interrupted or lost social ties and acculturation challenges after immigration to a new
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HOCl Rapidly Kills Corona, Flu, and Herpes to Prevent Aerosol Spread. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-29 H Guan,M Nuth,S R Weiss,A Fausto,Y Liu,H Koo,M S Wolff,R P Ricciardi
The COVID-19 pandemic has escalated the risk of SARS-CoV-2 transmission in the dental practice, especially as droplet-aerosol particles are generated by high-speed instruments. This has heightened awareness of other orally transmitted viruses, including influenza and herpes simplex virus 1 (HSV1), which are capable of threatening life and impairing health. While current disinfection procedures commonly
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Early Childhood Predictors for Dental Caries: A Machine Learning Approach. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-29 L Toledo Reyes,J K Knorst,F R Ortiz,B Brondani,B Emmanuelli,R Saraiva Guedes,F M Mendes,T M Ardenghi
We aimed to develop and validate caries prognosis models in primary and permanent teeth after 2 and 10 y of follow-up through a machine learning (ML) approach, using predictors collected in early childhood. Data from a 10-y prospective cohort study conducted in southern Brazil were analyzed. Children aged 1 to 5 y were first examined in 2010 and reassessed in 2012 and 2020 regarding caries development
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Mental Health and Oral Health in a Nationally Representative Cohort. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-29 A Kalaigian,B W Chaffee
Evidence connects mental illness to other adverse health conditions, including oral health. However, longitudinal associations between mental and oral health remain understudied. We aimed to examine mental health-oral health associations prospectively in a nationally representative US cohort. Data were from the Population Assessment of Tobacco and Health (PATH) Study. The Global Appraisal of Individual
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PD-1 Carried on Small Extracellular Vesicles Leads to OSCC Metastasis. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-29 L-Z Zhang,J-G Yang,H-F Xia,J Huang,H-M Liu,M Wu,B Liu,W-M Wang,G Chen
Immune checkpoint molecule PD-1, expressed on the cell surface, impairs antigen-driven activation of T cells and thus plays a critical role in tumorigenesis, progression, and the poor prognosis of oral squamous cell carcinoma (OSCC). In addition, increasing evidence indicates that PD-1 carried on small extracellular vesicles (sEVs) also mediates tumor immunity, although their contributions to OSCC
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Cuspal Shape Alterations by Bmp4 Directing Cell Proliferation and Apoptosis. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-29 E-J Kim,H-Y Kim,L Li,Q Tang,K-H Kim,H Ohshima,H-S Jung
The enamel knot (EK), located at the center of cap stage tooth germs, is a transitory cluster of nondividing epithelial cells. The EK acts as a signaling center that provides positional information for tooth morphogenesis and regulates the growth of tooth cusps. To identify species-specific cuspal patterns, this study analyzed the cellular mechanisms in the EK that were related to bone morphogenetic
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Sex and Age Effects on Healthy Gingival Transcriptomic Patterns. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-26 J L Ebersole,S S Kirakodu,L M Nguyen,O A Gonzalez
Many chronic inflammatory diseases demonstrate demographic associations such as sex, age, and race-ethnicity. Periodontitis has been found to be increased with age and in males. This study used nonhuman primates representing a human-like model for periodontitis and examined the gingival transcriptome stratified on sex and age. Thirty-six Macaca mulatta in 4 age groups-young (<3 y), adolescent (3-7
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Change in Geographic Accessibility to Dental Clinics Affects Access to Care. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-19 T Yamamoto,M Hanazato,H Hikichi,K Kondo,K Osaka,I Kawachi,J Aida
Access to dental clinics is a feature of the neighborhood service environment that may influence oral health care utilization. However, residential selection poses a challenge to causal inference. By studying the involuntary relocation of survivors of the 2011 Great East Japan Earthquake and Tsunami (GEJE), we examined the association between changes in geographic distance to dental clinics and dental
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High-Resolution Detection of Translocation of Oral Bacteria to the Gut. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-19 S Kageyama,S Sakata,J Ma,M Asakawa,T Takeshita,M Furuta,T Ninomiya,Y Yamashita
Ectopic enrichment of oral microbes in the gut is a notable alteration in gut microbial balance. These microbes are likely delivered from the oral cavity with saliva and food; however, evidence of oral-gut microbial transmission is insufficient and needs further investigation. In this observational study, we examined 144 pairs of saliva and stool samples collected from community-dwelling adults to
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FoxO1/NLRP3 Inflammasome Promotes Age-Related Alveolar Bone Resorption. J. Dent. Res. (IF 7.6) Pub Date : 2023-05-18 Z Wang,F Zhou,X Feng,H Li,C Duan,Y Wu,Y Xiong
Periodontitis is the utmost common chronic oral disease that exhibits intense susceptibility to aging. Aging is characterized by persistent sterile low-grade inflammation, leading to age-related periodontal complications represented by alveolar bone loss. Currently, forkhead transcription factor O1 (FoxO1) is generally believed to have a significant role in body development, senescence, cell viability
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A Variant in the IRF6 Promoter Associated with the Risk for Orofacial Clefting J. Dent. Res. (IF 7.6) Pub Date : 2023-05-09 M.-J. Li, P. Kumari, Y.-S. Lin, M.-L. Yao, B.-H. Zhang, B. Yin, S.-J. Duan, R.A. Cornell, M.L. Marazita, B. Shi, Z.-l. Jia
The single-nucleotide polymorphism (SNP) rs2235371 (IRF6 V274I) is associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in Han Chinese and other populations but appears to b...
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ScRNA-Seq Reveals a Distinct Osteogenic Progenitor of Alveolar Bone J. Dent. Res. (IF 7.6) Pub Date : 2023-05-06 A. Jin, H. Xu, X. Gao, S. Sun, Y. Yang, X. Huang, X. Wang, Y. Liu, Y. Zhu, Q. Dai, Q. Bian, L. Jiang
The metabolism and remodeling of alveolar bone are the most active among the whole skeletal system, which is related to the biological characteristics and heterogeneity of the bone mesenchymal stro...
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Mucoadhesive Vaccine Delivery Systems for the Oral Mucosa J. Dent. Res. (IF 7.6) Pub Date : 2023-05-06 K. Mokabari, M. Iriti, E.M. Varoni
Vaccine technology has evolved continuously since its beginning, and mucosal vaccination, including intranasal, sublingual, and oral administrations, has recently gained great scientific interest. ...
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Impact of Teeth on Social Participation: Modified Treatment Policy Approach J. Dent. Res. (IF 7.6) Pub Date : 2023-04-21 U. Cooray, G. Tsakos, A. Heilmann, R.G. Watt, K. Takeuchi, K. Kondo, K. Osaka, J. Aida
Social participation prevents social isolation and loneliness among older adults while having numerous positive effects on their health and well-being in rapidly aging societies. We aimed to estima...
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Identification of Dental Implant Systems Using a Large-Scale Multicenter Data Set J. Dent. Res. (IF 7.6) Pub Date : 2023-04-21 W. Park, F. Schwendicke, J. Krois, J.-K. Huh, J.-H. Lee
This study aimed to evaluate the efficacy of deep learning (DL) for the identification and classification of various types of dental implant systems (DISs) using a large-scale multicenter data set....
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Mechanistic Insights into Bioengineered Antibiofilm Enamel Pellicles J. Dent. Res. (IF 7.6) Pub Date : 2023-04-21 D.G. Moussa, R.W. Kung, J.S. Tse, W.L. Siqueira
Dental caries remains the most widespread chronic disease worldwide. Basically, caries originates within biofilms accumulated on dental enamel. Despite the nonrenewable nature of the enamel tissue,...
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B-Cell–Derived TGF-β1 Inhibits Osteogenesis and Contributes to Bone Loss in Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2023-04-21 Y. Chen, H. Wang, Q. Ni, T. Wang, C. Bao, Y. Geng, Y. Lu, Y. Cao, Y. Li, L. Li, Y. Xu, W. Sun
B cells play a vital role in the elimination of periodontal pathogens, the regulation of the immune response, and the induction of tissue destruction. However, the role of B cells in the dysfunctio...
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Integrating Oral Health into Primary Care: Perspectives for Older Adults. J. Dent. Res. (IF 7.6) Pub Date : 2023-04-21 S Nelson,E G R Kim,D C Kaelber
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Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries J. Dent. Res. (IF 7.6) Pub Date : 2023-04-11 D. Kahharova, V.Y. Pappalardo, M.J. Buijs, R.X. de Menezes, M. Peters, R. Jackson, A.T. Hara, G. Eckert, B. Katz, M.A. Keels, S.M. Levy, E. Zaura, B.W. Brandt, M. Fontana
Dental caries lesions are a clinical manifestation of disease, preceded by microbial dysbiosis, which is poorly characterized and thought to be associated with saccharolytic taxa. Here, we assessed...
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A 2-Stage Root Analog Implant with Compact Structure, Uniform Roughness, and High Accuracy J. Dent. Res. (IF 7.6) Pub Date : 2023-04-10 X. Yu, B. Feng, Y. Lan, J. Li, G. Ye, Q. Li, F. Zhao, Y. Gu, D. You, Y. Zhu, M. Yu, H. Wang, H. Yang
Immediate implant placement has the advantages of shortening the operation time, reducing the treatment cycle and cost. At present, this technology has been used widely, but the indications of imme...
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Osteoblastic RAR Inhibition Causes VAD-Like Craniofacial Skeletal Deformity J. Dent. Res. (IF 7.6) Pub Date : 2023-04-10 Q. Dai, S. Sun, A. Jin, X. Gong, H. Xu, Y. Yang, X. Huang, X. Wang, Y. Liu, J. Gao, X. Gao, J. Liu, Q. Bian, Y. Wu, L. Jiang
Retinoid signaling disorders cause craniofacial deformity, among which infants with maternal vitamin A deficiency (VAD) exhibited malformation of the eye, nose, palate, and parietal and jaw bone. P...
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Cyclic di-AMP Rescues Porphyromonas gingivalis–Aggravated Atherosclerosis J. Dent. Res. (IF 7.6) Pub Date : 2023-04-08 Q. Wu, Z. Li, Y. Zhang, K. Luo, X. Xu, J. Li, X. Peng, X. Zhou
Growing evidence demonstrates the relationship between periodontitis and atherosclerotic cardiovascular diseases. The periodontal pathogen Porphyromonas gingivalis (Pg) has been shown to contribute...
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Release of Interface Confined Water Significantly Improves Dentin Bonding J. Dent. Res. (IF 7.6) Pub Date : 2023-04-08 M. Pan, Z. Li, J. Xu, Y. Lei, C. Shu, W. Lao, Y. Chen, X. Li, H. Liao, Q. Luo, X. Li
Water residue and replacement difficulty cause insufficient adhesive infiltration in demineralized dentin matrix (DDM), which produces a defective hybrid layer and thus a bonding durability problem...
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Nonpublication and Selective Outcome Reporting of Oral Health Trials J. Dent. Res. (IF 7.6) Pub Date : 2023-03-30 H. Diakonoff, G. Khalil, S. Jungo, J.M. Treluyer, H. Fron-Chabouis, V. Smaïl-Faugeron
Less than one-quarter of oral health trials are registered in a public registry. However, no study has assessed the extent of study publication and selective outcome reporting bias in the field of ...
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Unequal Impact of COL1A1 and COL1A2 Variants on Dentinogenesis Imperfecta J. Dent. Res. (IF 7.6) Pub Date : 2023-03-23 P.M. Yamaguti, M. de La Dure-Molla, S. Monnot, Y.J. Cardozo-Amaya, G. Baujat, C. Michot, B.P.J. Fournier, M.C. Riou, E.C.C. Caldas Rosa, Y. Soares de Lima, P.A.C. dos Santos, G. Alcaraz, E.N.S. Guerra, L.C. Castro, S.F. de Oliveira, R. Pogue, A. Berdal, L.M. de Paula, J.F. Mazzeu, V. Cormier-Daire, A.C. Acevedo
Dentinogenesis imperfecta (DI) is the main orodental manifestation of osteogenesis imperfecta (OI) caused by COL1A1 or COL1A2 heterozygous pathogenic variants. Its prevalence varies according to th...
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Ligature-Induced Periodontitis Drives Colorectal Cancer: An Experimental Model in Mice J. Dent. Res. (IF 7.6) Pub Date : 2023-03-21 Y.T. Shi, J.M. He, Z.A. Tong, Y.J. Qian, Q.W. Wang, D.J.C. Jia, W.J. Zhu, Y.X. Zhao, B.B. Cai, S.J. Chen, M.S. Si
Periodontitis is a prevalent inflammatory oral disease associated with an increased risk of colorectal cancer. Experimental animal models are critical tools to investigate the effects and mechanism...
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Efficacy of a Mouthwash Containing CHX and CPC in SARS-CoV-2–Positive Patients: A Randomized Controlled Clinical Trial J. Dent. Res. (IF 7.6) Pub Date : 2023-03-21 E.L. Bonn, A. Rohrhofer, F.X. Audebert, H. Lang, D.L. Auer, K.J. Scholz, P. Schuster, J.J. Wenzel, K.-A. Hiller, W. Buchalla, J.M. Gottsauner, V. Vielsmeier, B. Schmidt, F. Cieplik
Soon after the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, preprocedural mouthwashes were recommended for temporarily reducing intraoral viral load and infectivity of individuals ...
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Development of Rat Caries-Induced Pulpitis Model for Vital Pulp Therapy J. Dent. Res. (IF 7.6) Pub Date : 2023-03-13 H. Huang, M. Okamoto, M. Watanabe, S. Matsumoto, K. Moriyama, S. Komichi, M. Ali, S. Matayoshi, R. Nomura, K. Nakano, Y. Takahashi, M. Hayashi
Rodent animal models for vital pulp therapy are commonly used in dental research because their tooth anatomy and cellular processes are similar to the anatomy and processes in humans. However, most...
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Chronological and Replicative Aging of CD51+/PDGFR-α+ Pulp Stromal Cells J. Dent. Res. (IF 7.6) Pub Date : 2023-03-15 L. Yao, F. Li, C. Yu, H. Wang, Y. Wang, L. Ye, F. Yu
As a crucial source of mesenchymal stromal cells, CD51+/PDGFR-α+ human dental pulp stromal cells (hDPSCs) are promising seeding cells for regenerative medicine. Cellular senescence hinders the tran...
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International Delphi Study to Optimize the Oral Health Section in interRAI J. Dent. Res. (IF 7.6) Pub Date : 2023-03-15 E. Schoebrechts, J. de Almeida Mello, P. Vandenbulcke, E. Palmers, A. Declercq, D. Declerck, J. Duyck, Oral Health Section Working Group
Introduction: The oral health (OH) of care-dependent older people is generally poor. Since caregivers are mainly responsible for older people’s daily care, they can be considered important intermed...
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Reduced Autophagy in Aged Trigeminal Neurons Causes Amyloid β Diffusion J. Dent. Res. (IF 7.6) Pub Date : 2023-03-15 R. Sonoda, E. Kuramoto, S. Minami, S.E. Matsumoto, Y. Ohyagi, T. Saito, T. Saido, K. Noguchi, T. Goto
The relationship between oral health and the development of Alzheimer’s disease (AD) in the elderly is not yet well understood. In this regard, the association between aging or neurodegeneration of...
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Plasticity of Dental Cell Types in Development, Regeneration, and Evolution J. Dent. Res. (IF 7.6) Pub Date : 2023-03-15 J. Krivanek, M. Buchtova, K. Fried, I. Adameyko
Recent years have improved our understanding of the plasticity of cell types behind inducing, building, and maintaining different types of teeth. The latest efforts were aided by progress in single...
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Prediction of Future Caries in 1-Year-Old Children via the Salivary Microbiome J. Dent. Res. (IF 7.6) Pub Date : 2023-03-15 R. Raksakmanut, P. Thanyasrisung, S. Sritangsirikul, K. Kitsahawong, A.L. Seminario, W. Pitiphat, O. Matangkasombut
Dental caries is the most common chronic disease in children that causes negative effects on their health, development, and well-being. Early preventive interventions are key to reduce early childh...
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Diabetes, Edentulism, and Cognitive Decline: A 12-Year Prospective Analysis J. Dent. Res. (IF 7.6) Pub Date : 2023-03-12 B. Wu, H. Luo, C. Tan, X. Qi, F.A. Sloan, A.R. Kamer, M.D. Schwartz, M. Martinez, B.L. Plassman
Diabetes mellitus (DM) is a recognized risk factor for dementia, and increasing evidence shows that tooth loss is associated with cognitive impairment and dementia. However, the effect of the co-oc...
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The Emerging Role of Accelerated Cellular Senescence in Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2023-03-12 R. Aquino-Martinez
Accelerated cellular senescence may be a crucial process for periodontitis progression because it integrates the damaging effects of major periodontitis risk factors. Cellular senescence is a manif...
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The Role of Gingival Fibroblasts in the Pathogenesis of Periodontitis. J. Dent. Res. (IF 7.6) Pub Date : 2023-03-08 A Wielento,K B Lagosz-Cwik,J Potempa,A M Grabiec
Gingival fibroblasts (GFs) are essential components of the periodontium, which are responsible for the maintenance of tissue structure and integrity. However, the physiological role of GFs is not restricted to the production and remodeling of the extracellular matrix. GFs also act as sentinel cells that modulate the immune response to oral pathogens invading the gingival tissue. As an important "nonclassical"
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Tough Adhesive Hydrogel for Intraoral Adhesion and Drug Delivery J. Dent. Res. (IF 7.6) Pub Date : 2023-03-08 D.T. Wu, B.R. Freedman, K.H. Vining, D.L. Cuylear, F.P.S. Guastaldi, Y. Levin, D.J. Mooney
Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are common chronic inflammatory conditions, manifesting as painful oral lesions that negatively affect patients’ quality of life. Cu...