AimTo assess the impact of active (APT) and supportive periodontal therapy (SPT) on the change in probing depth (PD) and annual tooth loss in partially and fully compliant and drop‐out patients.Material and MethodsData of 280 periodontally treated partially and fully compliant (regular supportive visits, SPT duration 5.5 ± 4.5 years) and 55 drop‐out patients (SPT and drop‐out duration 8.3 ± 3.8 years

Sleep is fundamental for health and well‐being. An adequate amount and quality of sleep is a cardinal component of a healthy lifestyle at the basis of the prevention of many non‐communicable chronic diseases. Recent evidence suggests that sleep disorders, particularly obstructive sleep apnea, represent an emerging risk factor for periodontal health. This review article provides a critical appraisal

Chronic inflammatory periodontal disease and its related condition, peri‐implant disease, are highly prevalent globally and require accurate and speedy diagnosis. The focus of this volume dedicated to diagnostics is to cover modern enhancements in accuracy, simplicity and speed. An international assortment of experts has been tasked with reviewing defined areas of current best practice as well innovation

Following a comprehensive patient examination, including the assessment of periodontal and peri‐implant diseases as well as considering the patient's needs, a pretherapeutic prognosis for each tooth and implant is given. Teeth and implants with a secure pretherapeutic prognosis require simple procedures and may be regarded as secure abutments for function and with a doubtful pretherapeutic prognosis

This review highlights the significance of interactions between the microbiota, immune system, nervous and hormonal systems, and the brain on periodontal health and disease. Microorganisms in the microbiota, immune cells, and neurons communicate via homeostatic nervous and hormonal systems, regulating vital body functions. By modulating pro‐inflammatory and anti‐inflammatory adaptive immune responses

BackgroundPrimary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by hyposalivation. Currently, there is limited evidence for the prognosis of dental implant treatment in Sjögren's syndrome.Aim/HypothesisWe hypothesized comparable clinical outcomes of implant‐supported restorations in pSS‐patients and control subjects, and improvement in oral health‐related quality of

ObjectivesThis study aimed to compare the accuracy of digital complete‐arch implant impressions with prefabricated aids using three intraoral scanners (IOSs) and explore the correlation between virtual deviation measurement and physical framework misfit.Materials and MethodsFour edentulous maxillary master models with four and six parallel and angular implants were fabricated and scanned by a laboratory

AimTo investigate the hypothesis supporting the link between periodontitis and dopaminergic neuron degeneration.Materials and MethodsAdult male Wistar rats were used to induce dopaminergic neuronal injury with 6‐hydroxydopamine (6‐OHDA) neurotoxin and experimental periodontitis via ligature placement. Motor function assessments were conducted before and after periodontitis induction in controls and

AimTo assess the impact of the timing of soft‐tissue augmentation (STA) on mean buccal bone changes following immediate implant placement (IPP) in the anterior maxilla.Materials and MethodsPatients with a failing tooth and intact buccal bone wall in the anterior maxilla (15–25) were enrolled in this randomized controlled trial. Following single IIP and socket grafting, they were randomly allocated

BackgroundThe polarization of macrophages into an anti‐inflammatory phenotype is crucial for resolving periodontal inflammation. It has been reported that B10 cells can regulate the immune response of macrophages during inflammation and are also able to regulate inflammation in periodontitis. However, whether B10 cells’ regulation function in periodontitis is related to macrophage polarization remains

This review aimed to answer the general question of whether autologous platelet concentrates (APCs, an autologous blood‐derivative) can improve the outcome of alveolar bone augmentation. Three clinical scenarios were assessed: horizontal/vertical bone augmentation in combination with implant placement (simultaneous approach), horizontal bone augmentation in a staged approach, and vertical bone augmentation

ObjectiveTo investigate the pull‐off forces on implant‐supported restorations caused by sticky food, to understand how much retention force cemented restorations must have to withstand chewing forces without unintentional retention loss. The influence of food type, restoration design, and surface treatment were investigated.Material and MethodsMonolithic implant‐supported CAD/CAM zirconia crowns were

AimTo investigate the association, as well as to characterize the associated panel of pro‐ and anti‐inflammatory markers, between the different components of the peri‐implant phenotype and the presence of peri‐implantitis/peri‐implant soft‐tissue dehiscence (PISTD).Materials and MethodsA total of 324 implants in 112 patients were included. The following components of the peri‐implant phenotype were

AimTo examine the independent and joint associations of oral microbiome diversity and diet quality with risks of all‐cause and cause‐specific mortality.Materials and MethodsWe included 7,055 eligible adults from the U.S. National Health and Nutrition Examination Survey (NHANES). Oral microbiome diversity was measured with α‐diversity, including the Simpson Index, observed amplicon sequence variants

ObjectivesThe objective of this study is to investigate the outcomes of clinically relevant laboratory studies regarding the cementation of implant‐supported restorations over ti‐bases.Materials and MethodsThe present study has been conducted according to PRISMA statement. An electronic search was performed, including publications up to March 2024, to identify studies investigating the parameters affecting

BackgroundLipocalin‐2 (LCN‐2) is an osteokine that suppresses appetite, stimulates insulin secretion, regulates bone remodeling, and is induced by proinflammatory cytokines. The aim of this work was to investigate the participation of LCN‐2 in periodontitis associated with type 2 diabetes (T2D) by evaluating alveolar bone loss, glycemic control, inflammation, and femur fragility.MethodsA murine model

The average age and obesity prevalence are increasing globally. Both aging and metabolic disease burden increase the risk of oral squamous cell carcinoma (OSCC) through profound effects on the immunological and metabolic characteristics within the OSCC tumor microenvironment. While the mechanisms that link aging and obesity to OSCC remain unclear, there is evidence that the antitumor responses are

In vitro models are invaluable tools for deconstructing the biological complexity of the periodontal ligament (PDL). Model systems that closely reproduce the 3-dimensional (3D) configuration of cell–cell and cell–matrix interactions in native tissue can deliver physiologically relevant insights. However, 3D models of the PDL that incorporate mechanical loading are currently lacking. Hence, we developed

Bone aging and decreased autophagic activity are related but poorly explored in the jawbone. This study aimed to characterize the aging jawbones and jawbone-derived stromal cells (JBSCs) and determine the role of autophagy in jawbone mass decline. We observed that the jawbones of older individuals and mice exhibited similar age-related bone loss. Furthermore, leptin receptor (LepR)–lineage cells served

The association between periodontal diseases and the risk of gastrointestinal cancers, especially site-specific gastrointestinal cancers, remains unclear. Here, we comprehensively searched PubMed, EMBASE, Web of Science, and Google Scholar from inception to April 2024 to identify relevant studies. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with a random-effects

Sleep bruxism (SB) affects a considerable part of the population and is associated with neuroticism, stress, and anxiety in various studies. However, the causal mechanisms between neuroticism and SB have not been examined. Understanding the reasons for SB is important as understanding bruxism may allow improved comprehensive management of the disorders and comorbidities related to it. Previous studies

BackgroundTo assess how the diagnostic reproducibility of the 2018 Classification of Gingival Recession Defects (GRD) could be applied when comparing in‐person chairside measurements with photographic measurements.MethodsThirty‐four GRD were photographed and evaluated by 4 masked operators. For each case, the operators measured twice recession type (RT), recession depth (RD), keratinized tissue width

BackgroundThis study aimed to analyze the influence of concave and cylindrical abutments on peri‐implant soft tissue. Dimensions, collagen fiber orientation, and immunohistochemical data were assessed.MethodsA multicenter, split‐mouth, double‐blind randomized clinical trial was conducted. Two groups were analyzed: cylindrical abutments and concave abutments. After a 12‐week healing period, peri‐implant

BackgroundTo compare the efficacy of combined treatment of Er:YAG laser (ERL) and low‐level laser therapy (LLLT) with single laser applications, and scaling and root planing (SRP) for non‐surgical periodontal treatment.MethodsIn a randomized controlled trial, 25 non‐smoking Stage II or Stage III periodontitis patients were recruited. The four intraoral quadrants were randomly assigned to four different

BackgroundThis study investigated the effect of a 4‐week free‐sugar avoidance on periodontal parameters during periodontal therapy.MethodsTwenty‐one patients with untreated periodontitis and daily free‐sugar intake were allocated to a sugar avoidance group (SAG) and a control group (CG). The SAG received a 45‐min dietary consultation and was instructed to avoid free sugars during the following 4 weeks

ObjectiveThe aim of this non‐inferiority randomized clinical trial was to compare the surgical and healing complications, vertical bone gain, and volumetric bone changes after vertical ridge augmentation using two different approaches: customized Ti‐reinforced d‐PTFE mesh versus customized CAD/CAM Ti‐mesh.Materials and MethodsFifty patients with vertical bone defects were randomly treated with Ti‐reinforced

Chronic inflammation poses challenges to effective cancer treatment. Although anti‐inflammatory therapies have shown short‐term benefits, their long‐term implications may be unfavorable because they fail to initiate the necessary inflammatory responses. Recent research underscores the promise of specialized pro‐resolving mediators, which play a role in modulating the cancer microenvironment by promoting

BackgroundTooth‐ and implant‐supported fixed dental prostheses are well‐documented and aesthetic treatment alternatives, and after a comprehensive periodontal treatment, a protocol with a good long‐term prognosis if the maintenance program is strictly followed.AimTo reexamine a pre‐existing patient cohort in order to obtain estimated long‐term survival and complication outcomes of fixed dental prostheses

Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's esthetic awareness rises. However, adults may already have

ObjectiveThis study aimed to assess clinical efficacy of 4‐mm‐short implants in patients with posterior severe vertical bone atrophy in the medium‐ and long‐term follow‐up.Materials and MethodsPatients rehabilitated with 4‐mm‐short implants in the posterior atrophic jaws, with a minimum follow‐up of 3 years post‐loading, were included in the study. Data were collected for eligible patients, and marginal

ObjectivesTo investigate the effects of alveolar ridge preservation (ARP) on ridge height, sinus pneumatization and the potential need for lateral sinus augmentation following extraction in the posterior maxilla.Materials and MethodsThis randomized controlled pilot study included 28 patients requiring extraction in the posterior maxilla with bone height between 6 and 8 mm. The sites were randomly allocated

ObjectivesCollagen membranes are extensively used for guided bone regeneration procedures, primarily for horizontal bone augmentation. More recently, it has been demonstrated that collagen membranes promote bone regeneration. Present study aimed at assessing if structural modifications of collagen membranes may enhance their osteoconductive capacity.MethodsTwenty‐four adult Wistar rats were used. Bilateral

ObjectivesTo compare marginal bone levels, biological, and technical outcomes of screw‐retained versus cemented all‐ceramic implant‐supported zirconia‐based single crowns after an observation period of 7.5 years.MethodsForty‐four single implants in the esthetic zone in 44 patients (22 females, 22 males) were randomly assigned to two types of restorations: SR (screw‐retained); veneered one‐piece zirconia

BACKGROUND Periodontal diseases are chronic inflammatory conditions that require early screening for effective long-term management. Oral neutrophil counts (ONCs) correlate with periodontal inflammation. This study investigates a point-of-care test using a neutrophil enzyme activity (NEA) colorimetric strip for measuring periodontal inflammation. METHODS This prospective study had two phases. Phase

ObjectiveTo investigate the association between interleukin‐8 (IL‐8) levels in gingival crevicular fluid (GCF) and total oral fluid (TOF) and the responsiveness to steps 1 and 2 of periodontal therapy.Materials and MethodsOne‐hundred and fifty‐nine patients affected by periodontitis received steps 1 and 2 of periodontal therapy. At baseline, TOF and GCF samples were collected and analysed for IL‐8

AimTo investigate whether oral microbiome diversity is associated with all‐cause mortality in the general US population and in individuals with chronic diseases.Materials and MethodsWe included 8224 individuals with oral microbiome diversity data from the National Health and Nutrition Examination Survey (2009–2012), representing 164,000,205 US adults, using a survey‐weighted analysis method. Cox regression

ObjectiveTo describe the evolution and aims of the European Association for Osseointegration (EAO) Junior Committee (JC).Materials and MethodsFormer members of the EAO JC and members of the board were interviewed, and current projects and initiatives were summarized.ResultsThe EAO JC was launched in 2007 as the first young committee in Europe. Despite initial skepticism, it became a famous initiative

ObjectiveDental implants are a considerable financial burden for elderly people and their caregivers. This study aimed to calculate the estimated economic costs of dental implants on the Korean older population.Materials and MethodsThe economic costs of dental implants for adults aged 75 years and older were estimated from a societal perspective, considering both direct and indirect expenditures. We

AimTo assess the possibility of vertical alveolar ridge augmentation by means of activation of the periosteum.Materials and MethodsSix adult male Beagle dogs were used for the study. All premolars and first molars were extracted, and one vertical saucer‐shaped bony defect was created on each side of the mandible. After 3 months of healing, full‐thickness muco‐periosteal flaps were elevated, and one

While autologous platelet concentrates (APCs) have gained traction as promising regenerative materials in recent years, their impact on wound healing and tissue regeneration in periapical hard tissue defects remains controversial. Endodontic microsurgery (EMS) has embraced the potential of platelet concentrates, particularly L‐PRF (Leucocyte‐Platelet‐Rich Fibrin) and PRP (Platelet‐Rich Plasma), as

AimTo investigate the influence of diabetes mellitus (DM) in a murine model of peri‐implantitis (PI).Materials and MethodsTwenty‐seven 4‐week‐old C57BL/6J male mice had their first and second maxillary left molars extracted. Eight weeks later, one machined implant was placed in each mouse. Four weeks after osseointegration, the mice were divided into three groups: (a) control (C), (b) PI and (c) DM

ObjectiveThe use of extracted teeth has been introduced as an option for bone grafting. However, the current method requires special machines and solutions, posing significant time and cost. The aim of this study was to evaluate the clinical performance of autogenous raw tooth particles (RTP), a grafting material made from a ground tooth using basic equipment, for alveolar ridge preservation.Materials

BackgroundIt is unclear whether an intact buccal bony plate is a prerequisite for immediate implant placement in postextraction sockets. The aim of this 10‐year randomized controlled trial was to compare peri‐implant soft and hard tissue parameters, esthetic ratings of, and patient‐reported satisfaction with immediate implant placement in postextraction sockets with buccal bony defects ≥5 mm in the

Understanding patient responses to periodontal regeneration is crucial. This systematic review and meta‐analysis addressed two key questions: (a) the impact of periodontal regeneration on patient‐reported outcome measures (PROMs) for intrabony and furcation involvement and (b) the cost‐effectiveness of periodontal regeneration for treating periodontal defects. Twenty‐four studies were included, with

BackgroundThis study investigated the agreement among dentists in classifying gingival phenotype (GP) through periodontal probe visibility (PPV) assessment with various probe types and the visual method. Additionally, the relationship between GP classifications and gingival thickness (GT) was evaluated.MethodsPhotographs were taken with standard periodontal probe (SPP), color‐coded periodontal probe

AimTo describe the microbiological composition of subgingival dental plaque and molecular profile of gingival crevicular fluid (GCF) of periodontal furcation‐involved defects.Materials and MethodsFifty‐seven participants with periodontitis contributed with a degree II–III furcation involvement (FI), a non‐furcation (NF) periodontal defect and a periodontally healthy site (HS). Subgingival plaque was

AimThe aim of this analysis was to compare a clinical periodontal prognostic system and a developed and externally validated artificial intelligence (AI)‐based model for the prediction of tooth loss in periodontitis patients under supportive periodontal care (SPC) for 10 years.Materials and MethodsClinical and radiographic parameters were analysed to assign tooth prognosis with a tooth prognostic system

BackgroundThis case report demonstrates the effective clinical application of a 3D‐printed, patient‐specific polycaprolactone (PCL) resorbable scaffold for staged alveolar bone augmentation.ObjectiveTo evaluate the effectiveness of a 3D‐printed PCL scaffold in facilitating alveolar bone regeneration and subsequent dental implant placement.Materials and MethodsA 46‐year‐old man with a missing tooth

BackgroundThis study aimed to investigate the relationship between the pan‐immune‐inflammation value (PIV) and periodontitis based on a large national survey.MethodsIn the present cross‐sectional study, data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009–2014, which included a total of 10,300 participants. The categorization of periodontitis was based on the 2017

AimTo identify serum‐ and salivary‐derived inflammatory biomarkers of periodontitis progression and determine their response to non‐surgical treatment.Materials and MethodsPeriodontally healthy (H; n = 113) and periodontitis patients (P; n = 302) were monitored bi‐monthly for 1 year without therapy. Periodontitis patients were re‐examined 6 months after non‐surgical periodontal therapy (NSPT). Participants

Conflicting evidence suggests a link between diabetes-related microvascular complications and periodontitis. Reliable estimates have been hindered by small sample sizes and residual confounding. Moreover, the combined effects of microvascular complications and dyslipidemia on periodontitis have not been explored. Therefore, this study aimed to investigate the association between individual and combined