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Orthodontic retention: Rationale and periodontal implications Periodontol. 2000 (IF 18.6) Pub Date : 2024-03-18 Padhraig S. Fleming, Nikolaos Pandis
Post-treatment change in the form of true relapse and physiological and maturational effects is common following orthodontics. The unpredictable nature of these manifestations dictates a conservative, near-universal approach to retention. Both fixed and removable forms of retention are popular with the latter constrained by variable levels of adherence particularly in the medium- to long-term. Fixed
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AZGP1 Aggravates Macrophage M1 Polarization and Pyroptosis in Periodontitis J. Dent. Res. (IF 7.6) Pub Date : 2024-03-16 S. Yang, Y. Yin, Y. Sun, D. Ai, X. Xia, X. Xu, J. Song
Periodontal tissue destruction in periodontitis is a consequence of the host inflammatory response to periodontal pathogens, which could be aggravated in the presence of type 2 diabetes mellitus (T2DM). Accumulating evidence highlights the intricate involvement of macrophage-mediated inflammation in the pathogenesis of periodontitis under both normal and T2DM conditions. However, the underlying mechanism
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Leukemia inhibitory factor protects against experimental periodontitis through immuno‐modulations of both macrophages and periodontal ligament fibroblasts J. Periodontol. (IF 4.3) Pub Date : 2024-03-16 Yanjing Ou, Le Fan, Xiaoqi Wang, Haibin Xia, Mengwen Cheng, Jing Huang, Youde Liang, Yining Wang, Yi Zhou
BackgroundTo explore the role of leukemia inhibitory factor (LIF) in periodontitis via in vivo and in vitro experiments.MethodsThe second upper molar of LIF knockout mice and their wild‐type littermates were ligated for 8 days. Micro‐computed tomography (micro‐CT), histological analysis, and quantitative real‐time polymerase chain reaction (qRT‐PCR) were performed. The expression levels of proinflammatory
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Differences between first‐ and second‐generation autologous platelet concentrates Periodontol. 2000 (IF 18.6) Pub Date : 2024-03-15 Elena Calciolari, Marina Dourou, Aliye Akcali, Nikolaos Donos
AbstractAutologous platelet concentrates (APCs) applied alone or combined with other biomaterials are popular bioactive factors employed in regenerative medicine. The main biological rationale of using such products is to concentrate blood‐derived growth factors and cells into the wound microenvironment to enhance the body's natural healing capacity. First‐generation APC is represented by platelet‐rich
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A multi‐centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the buccal aspect of single implants: 3‐Year results J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-15 Lenz Surdiacourt, Véronique Christiaens, Thomas De Bruyckere, Stefanie De Buyser, Aryan Eghbali, Stijn Vervaeke, Faris Younes, Jan Cosyn
AimTo compare connective tissue graft (CTG) with collagen matrix (CMX) in terms of increase in buccal soft tissue profile (BSP) when applied at single implant sites.Materials and MethodsPatients with a single tooth gap in the anterior maxilla and horizontal mucosa defect were enrolled in a multi‐centre randomized controlled trial. All were fully healed sites with a bucco‐palatal bone dimension of at
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A Wnt10a-Notch signaling axis controls Hertwig’s epithelial root sheath cell behaviors during root furcation patterning Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-03-13 Kai Sun, Miao Yu, Jiayu Wang, Hu Zhao, Haochen Liu, Hailan Feng, Yang Liu, Dong Han
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Effects of implant placement timing and type of soft‐tissue grafting on histological and histomorphometric outcomes in a preclinical canine model J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-14 Hyun‐Chang Lim, Kwang‐Seok Lee, Seung‐Yun Shin, Ronald E. Jung, Ui‐Won Jung, Daniel S. Thoma
AimTo determine the effects of implant timing and type of soft‐tissue grafting on histological and histomorphometric outcomes in a preclinical model.Materials and MethodsFour implant placement protocols were randomly applied at the mesial root sites of the third and fourth mandibular premolars in 10 mongrel dogs: immediate placement (group IP), early placement (group EP), delayed placement with/without
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Promising dawn in tumor microenvironment therapy: engineering oral bacteria Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-03-13 Zifei Wang, Wansu Sun, Ruixue Hua, Yuanyin Wang, Yang Li, Hengguo Zhang
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Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals J. Periodontol. (IF 4.3) Pub Date : 2024-03-13 Sungeun Stephanie Koo, Jussara G. Fernandes, Lu Li, Hong Huang, Ikramuddin Aukhil, Peter Harrison, Patricia I. Diaz, Luciana M. Shaddox
BackgroundThe aim of the present study was to evaluate the subgingival microbiome in patients with grade C molar‐incisor pattern periodontitis (C‐MIP) affecting the primary or permanent dentitions.MethodsDNA was isolated from subgingival biofilm samples from diseased and healthy sites from 45 C‐MIP patients and subjected to phylogenetic microarray analysis. C‐MIP sites were compared between children
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Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-12 Sam Asher, Anna Liisa Suominen, Ruth Stephen, Tiia Ngandu, Seppo Koskinen, Alina Solomon
AimEmerging evidence suggests association of tooth loss with impaired cognition. However, the differential effects of anterior versus posterior tooth loss, occlusal support loss and chewing ability are not considered comprehensively.Materials and MethodsWe conducted cross‐sectional (N = 4036) and longitudinal analyses (N = 2787) on data from Health 2000 and 2011 Surveys for associations of posterior
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Effect of non‐surgical periodontal therapy on salivary histone deacetylases expression: A prospective clinical study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-12 Andrew Liaw, Chun Liu, Mark Bartold, Sašo Ivanovski, Pingping Han
AimTo evaluate the effect of non‐surgical periodontal therapy (NSPT) on salivary histone deacetylases (HDACs) gene expression in patients with Stage III–IV periodontitis at baseline and at 3 and 6 months post NSPT treatment.Materials and MethodsTwenty patients completed the study. Periodontitis (as well as the corresponding staging and grading) was diagnosed according to the 2017 World Workshop Classification
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Guided bone regeneration for peri‐implant augmentation: A retrospective study comparing two surgical techniques with a mean follow‐up of 26 months Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-03-12 Yeyu Liu, Dongping Lan, Jiayu Gao, Chen Deng, Yi Man
ObjectivesTo introduce a modified guided bone regeneration (GBR) technique using intact periosteum and deproteinized bovine bone mineral (DBBM) for peri‐implant augmentation and compare the clinical outcomes with those of conventional GBR.Materials and MethodsPatients who received peri‐implant augmentation in posterior sites between 2015 and 2021 were reviewed in this study. Group A was treated with
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Enhanced immunomodulation and periodontal regeneration efficacy of subgingivally delivered progranulin‐loaded hydrogel as an adjunct to non‐surgical treatment for Class II furcation involvement in dogs J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-11 Wenchuan Liu, Aimei Song, Yixi Wu, Pizhang Gong, Jingjing Zhao, Liguo Zhang, Xinyang Liu, Ruwei Wang, Hongmei Guo, Pishan Yang
AimTo evaluate the effect of subgingival delivery of progranulin (PGRN)/gelatin methacryloyl (GelMA) complex as an adjunct to scaling and root planing (SRP) on an experimental periodontitis dog model with Class II furcation involvement (FI).Materials and MethodsA Class II FI model was established, and the defects were divided into four treatment groups: (a) no treatment (control); (b) SRP; (c) SRP
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Sugar‐sweetened beverage consumption and periodontitis among adults: A population‐based cross‐sectional study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-08 Silas Alves‐Costa, Gustavo G. Nascimento, Marco A. Peres, Huihua Li, Susilena Arouche Costa, Cecilia Claudia Costa Ribeiro, Fábio Renato Manzolli Leite
AimInvestigating the association between sugar‐sweetened beverages (SSBs) and periodontitis and whether the awareness of diabetes modifies this relationship.Materials and MethodsCross‐sectional analysis was conducted using the National Health and Nutrition Examination Survey (NHANES III) data involving US adults aged 30–50. Periodontitis was classified according to the Centers for Disease Control and
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Immediate implant placement with immediate or delayed provisionalization in the maxillary aesthetic zone: A 10‐year randomized trial J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-08 Vincent J. J. Donker, Gerry M. Raghoebar, Kirsten W. Slagter, Diederik F. M. Hentenaar, Arjan Vissink, Henny J. A. Meijer
AimTo compare the marginal bone level of immediately placed implants, with either immediate or delayed provisionalization (IP or DP), in the maxillary aesthetic zone after 10 years of function.Materials and MethodsParticipants with a failing tooth in the maxillary aesthetic zone were randomly assigned to immediate implant placement with either IP (n = 20) or DP (n = 20) after primary wound closure
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Improvement of periodontal parameters following intensive diabetes care and supragingival dental prophylaxis in patients with type 2 diabetes: A prospective cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-07 Koji Mizutani, Isao Minami, Risako Mikami, Daisuke Kido, Kohei Takeda, Keita Nakagawa, Shu Takemura, Natsumi Saito, Hiromi Kominato, Eri Sakaniwa, Kuniha Konuma, Yuichi Izumi, Yoshihiro Ogawa, Takanori Iwata
AimThis study aimed to investigate the effects of diabetes care on periodontal inflammation.Materials and MethodsThis prospective cohort study included 51 Japanese patients with type 2 diabetes who underwent intensive diabetes care including educational hospitalization and regular outpatient treatment for 6 months. Dental prophylaxis without subgingival scaling was provided three times during the observational
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Regeneration of alveolar bone defects in the experimental pig model: A systematic review and meta‐analysis Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-03-07 Siddharth Shanbhag, Carina Kampleitner, Javier Sanz‐Esporrin, Stein‐Atle Lie, Reinhard Gruber, Kamal Mustafa, Mariano Sanz
ObjectivePigs are emerging as a preferred experimental in vivo model for bone regeneration. The study objective was to answer the focused PEO question: in the pig model (P), what is the capacity of experimental alveolar bone defects (E) for spontaneous regeneration in terms of new bone formation (O)?MethodsFollowing PRISMA guidelines, electronic databases were searched for studies reporting experimental
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Prevalence of self‐reported severe periodontitis: Data from the population‐based CONSTANCES cohort J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-02 Emmanuel Wiernik, Adeline Renuy, Sofiane Kab, Philippe Gabriel Steg, Marcel Goldberg, Marie Zins, Giuseppina Caligiuri, Philippe Bouchard, Maria Clotilde Carra
AimTo assess the prevalence of severe periodontitis based on the population‐based CONSTANCES cohort using a validated self‐reported questionnaire.Materials and MethodsIndividuals were selected from the adult population in France using a random sampling scheme. Analyses were restricted to those invited in 2013–2014 who completed the periodontal health questionnaire at the 2017 follow‐up. The risk of
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Expert consensus on difficulty assessment of endodontic therapy Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-03-01 Dingming Huang, Xiaoyan Wang, Jingping Liang, Junqi Ling, Zhuan Bian, Qing Yu, Benxiang Hou, Xinmei Chen, Jiyao Li, Ling Ye, Lei Cheng, Xin Xu, Tao Hu, Hongkun Wu, Bin Guo, Qin Su, Zhi Chen, Lihong Qiu, Wenxia Chen, Xi Wei, Zhengwei Huang, Jinhua Yu, Zhengmei Lin, Qi Zhang, Deqin Yang, Jin Zhao, Shuang Pan, Jian Yang, Jiayuan Wu, Yihuai Pan, Xiaoli Xie, Shuli Deng, Xiaojing Huang, Lan Zhang, Lin Yue
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy (RCT). Recent research, encompassing
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Expert consensus on irrigation and intracanal medication in root canal therapy Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-03-01 Xiaoying Zou, Xin Zheng, Yuhong Liang, Chengfei Zhang, Bing Fan, Jingping Liang, Junqi Ling, Zhuan Bian, Qing Yu, Benxiang Hou, Zhi Chen, Xi Wei, Lihong Qiu, Wenxia Chen, Wenxi He, Xin Xu, Liuyan Meng, Chen Zhang, Liming Chen, Shuli Deng, Yayan Lei, Xiaoli Xie, Xiaoyan Wang, Jinhua Yu, Jin Zhao, Song Shen, Xuedong Zhou, Lin Yue
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. Additionally, ambiguous clinical indications for root canal
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Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-29 Gan Xiong, Nan Xie, Min Nie, Rongsong Ling, Bokai Yun, Jiaxiang Xie, Linlin Ren, Yaqi Huang, Wenjin Wang, Chen Yi, Ming Zhang, Xiuyun Xu, Caihua Zhang, Bin Zou, Leitao Zhang, Xiqiang Liu, Hongzhang Huang, Demeng Chen, Wei Cao, Cheng Wang
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Periodontitis is associated with decreased experimental pressure pain tolerance: The Tromsø Study 2015–2016 J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-03-01 Elin Hadler‐Olsen, Natalia Petrenya, Birgitta Jönsson, Ólöf Anna Steingrímsdóttir, Audun Stubhaug, Christopher Sivert Nielsen
AimTo assess the relationship between periodontitis and experimental pain tolerance.Materials and MethodsParticipants from the population‐based seventh survey of the Tromsø Study with data on periodontitis were included (n = 3666, 40–84 years old, 51.6% women). Pain tolerance was assessed through (i) pressure pain tolerance (PPT) test with a computerized cuff pressure algometry on the leg, and (ii)
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Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-28 Ziming Wang, Hao Zeng, Can Wang, Jiaolong Wang, Jing Zhang, Shuyuan Qu, Yue Han, Liu Yang, Yueqi Ni, Wenan Peng, Huan Liu, Hua Tang, Qin Zhao, Yufeng Zhang
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The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-28 Wenhao Zheng, Xiaofeng Lu, Guangjin Chen, Yufeng Shen, Xiaofei Huang, Jinfeng Peng, Jiajia Wang, Ying Yin, Wencheng Song, Mengru Xie, Shaoling Yu, Lili Chen
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Accuracy of edentulous full‐arch implant impression: An in vitro comparison between conventional impression, intraoral scan with and without splinting, and photogrammetry Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-02-29 Jing Cheng, Haidong Zhang, Hailin Liu, Junying Li, Hom‐Lay Wang, Xian Tao
ObjectivesThe purpose of this in vitro study was to compare the trueness and precision of complete arch implant impressions using conventional impression, intraoral scanning with and without splinting, and stereophotogrammetry.Materials and MethodsAn edentulous model with six implants was used in this study. Four implant impression techniques were compared: the conventional impression (CI), intraoral
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Neighborhood Deprivation and Changes in Oral Health in Older Age: A Longitudinal Population-Based Study J. Dent. Res. (IF 7.6) Pub Date : 2024-02-28 S.G. Ganbavale, E. Papachristou, J.C. Mathers, A.O. Papacosta, L.T. Lennon, P.H. Whincup, S.G. Wannamethee, S.E. Ramsay
The aim of this study was to examine the extent to which neighborhood-level socioeconomic factors (objective and perceived) are associated with poor oral health in older adults over time, independent of individual socioeconomic position. Data for this cross-sectional and longitudinal observation study came from a socially and geographically representative cohort of men aged 71 to 92 y in 2010–12 (
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IL-36 Regulates Neutrophil Chemotaxis and Bone Loss at the Oral Barrier J. Dent. Res. (IF 7.6) Pub Date : 2024-02-28 J. Liu, H. Meng, Y. Mao, L. Zhong, W. Pan, Q. Chen
Tissue-specific mechanisms regulate neutrophil immunity at the oral barrier, which plays a key role in periodontitis. Although it has been proposed that fibroblasts emit a powerful neutrophil chemotactic signal, how this chemotactic signal is driven has not been clear. The objective of this study was to investigate the site-specific regulatory mechanisms by which fibroblasts drive powerful neutrophil
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Gingipains may be one of the key virulence factors of Porphyromonas gingivalis to impair cognition and enhance blood–brain barrier permeability: An animal study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-28 Fulong Li, Chunliang Ma, Shuang Lei, Yaping Pan, Li Lin, Chunling Pan, Qian Li, Fengxue Geng, Dongyu Min, Xiaolin Tang
AimBlood–brain barrier (BBB) disorder is one of the early findings in cognitive impairments. We have recently found that Porphyromonas gingivalis bacteraemia can cause cognitive impairment and increased BBB permeability. This study aimed to find out the possible key virulence factors of P. gingivalis contributing to the pathological process.Materials and MethodsC57/BL6 mice were infected with P. gingivalis
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Mechanical stability of posterior implant‐supported monolithic zirconia cantilever on titanium‐base abutments. An in vitro study Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-02-28 Carme Riera, Duygu Karasan, Irena Sailer, Phillipe Mojon, Vincent Fehmer, João Pitta
PurposeInvestigate survival and technical complications of two‐unit posterior implant‐supported cantilever made of monolithic zirconia on titanium‐base abutments (Zr‐TiB) vs. porcelain‐fused‐to‐metal on castable gold abutments (PFM‐GA) using two different implant connections, internal butt‐joint (IBJ) and internal conical (IC).Materials and MethodsForty‐eight implants (4.3 mm diameter) were divided
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The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-27 Yutaro Ando, Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Akira Yamaguchi, Kazuyuki Ishihara, Hiroshi Takayanagi
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The role of viruses in oral mucosal lesions Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-27 Henrik Dommisch, Andrea Maria Schmidt‐Westhausen
The mucosa of the oral cavity is exposed to a large number of different microorganisms such as archaea, bacteria, fungi, parasites, and viruses. Among those, viruses cause specific infections, which can easily be transmitted from one person to another. The infectious route may not only include patients and their relatives but also the dental professional team. Thus, a wide knowledge regarding specific
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Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-27 Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw
Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent clinical studies are described that evaluate how the treatment
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Injectable Tissue-Specific Hydrogel System for Pulp–Dentin Regeneration J. Dent. Res. (IF 7.6) Pub Date : 2024-02-27 Y. Han, J. Xu, H. Chopra, Z. Zhang, N. Dubey, W.L. Dissanayaka, J.E. Nör, M.C. Bottino
The quest for finding a suitable scaffold system that supports cell survival and function and, ultimately, the regeneration of the pulp–dentin complex remains challenging. Herein, we hypothesized that dental pulp stem cells (DPSCs) encapsulated in a collagen-based hydrogel with varying stiffness would regenerate functional dental pulp and dentin when concentrically injected into the tooth slices. Collagen
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Exploring Recent Decreases in First Molar Sealants among US Children J. Dent. Res. (IF 7.6) Pub Date : 2024-02-27 M. Lin, S. O. Griffin, C. H. Li, L. Wei, L. Espinoza, C. Y. Wang, G. Thornton-Evans
Analyses of National Health and Nutrition Examination Survey (NHANES) data suggested a significant decrease in sealant prevalence among children between 2011 to 2014 and 2015 to 2018. We explore whether this decrease could be associated with possible changes in 1) clinical sealant delivery, 2) dental materials (i.e., increased use of glass ionomer [GI] sealants resulting in an inability to detect sealant
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A Bilayer Method for Measuring Toughness and Strength of Dental Ceramics J. Dent. Res. (IF 7.6) Pub Date : 2024-02-27 H. Chai, J. Russ, S. Vardhaman, C.H. Lim, Y. Zhang
The ever-increasing usage of ceramic materials in restorative dentistry necessitates a simple and effective method to evaluate flexural strength σF and fracture toughness KC. We propose a novel method to determine these quantities using a bilayer specimen composed of a brittle plate adhesively bonded onto a transparent polycarbonate substrate. When this bilayer structure is placed under spherical indentation
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Single-Cell Transcriptomic Analysis of Salivary Gland Endothelial Cells J. Dent. Res. (IF 7.6) Pub Date : 2024-02-27 A.L. Altrieth, J. Kenney, D.A. Nelson, E.G. Suarez, V. Gellatly, S. Gabunia, M. Larsen
Vascular endothelial cells have important tissue-specific functions in fibrosis and regeneration. In the salivary gland, endothelial cells are required for proper development, but their roles within adult glands are largely unknown. To identify ligand–receptor interactions between endothelial cells and other cell types that may be important during fibrosis and regeneration, we used a reversible ductal
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Tooth loss during supportive periodontal care: A prospective study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-27 Fatemah Hasan, Antonio Magan‐Fernandez, Aliye Akcalı, Chuanming Sun, Nikos Donos, Luigi Nibali
AimTo assess periodontal stability and the association between tooth‐ and patient‐related factors and tooth loss during supportive periodontal care (SPC).Materials and MethodsA prospective observational study was carried out on previously treated periodontitis patients followed up for 5 years in SPC. The risk profile (low, moderate, high) of each patient based on periodontal risk assessment (PRA) scoring
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Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-26 Xiao Yang, Hui Zhao, Rui Li, Yang Chen, Zhi Xu, Zhengjun Shang
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Digital pathology-based artificial intelligence models for differential diagnosis and prognosis of sporadic odontogenic keratocysts Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-26 Xinjia Cai, Heyu Zhang, Yanjin Wang, Jianyun Zhang, Tiejun Li
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The Essential Role of Proteoglycans and Glycosaminoglycans in Odontogenesis J. Dent. Res. (IF 7.6) Pub Date : 2024-02-26 J. Chen, T. Sun, B. Lin, B. Wu, J. Wu
Tooth development and regeneration are regulated through a complex signaling network. Previous studies have focused on the exploration of intracellular signaling regulatory networks, but the regulatory roles of extracellular networks have only been revealed recently. Proteoglycans, which are essential components of the extracellular matrix (ECM) and pivotal signaling molecules, are extensively involved
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Critical appraisal of YouTube videos regarding peri‐implant diseases and conditions: A cross‐sectional analysis Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-02-24 Amit Gaikwad, Pranidhipurnima Rachh, Kaustubh Raut, Jyoti Nadgere
PurposeTo critically appraise the quality and reliability of YouTube videos regarding peri‐implant diseases and conditions as a source of information for patients, students, and young clinicians.Materials and MethodsIn March 2023, electronic searches were performed on YouTube website to identify videos related to peri‐implant diseases and conditions. We considered only the relevant 250 English‐language
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LIGHT protein: A novel gingival crevicular fluid biomarker associated with increased probing depth after periodontal surgery J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-23 Anders Esberg, Elin Kindstedt, Catrine Isehed, Susanne Lindquist, Anders Holmlund, Pernilla Lundberg
AimTo evaluate the protein profiles in gingival crevicular fluid (GCF) in relation to clinical outcomes after periodontal surgery and examine if any selected proteins affect the mRNA expression of pro‐inflammatory cytokines in human gingival fibroblasts.Materials and MethodsThis exploratory study included 21 consecutive patients with periodontitis. GCF was collected, and the protein pattern (n = 92)
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Periodontal pockets: Predictors for site‐related worsening after non‐surgical therapy—A long‐term retrospective cohort study J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-22 Marco M. Herz, Nina Hoffmann, Sandra Braun, Stefan Lachmann, Valentin Bartha, Hari Petsos
AimTo evaluate site‐related changes in periodontal pocket depth (PPD) after non‐surgical periodontal therapy and to identify predictors for PPD changes in a retrospective patient data analysis.Materials and MethodsPPD, clinical attachment level, bleeding on probing, tooth mobility (TM), furcation involvement (FI), abutment status, adherence to supportive periodontal care (SPC) and SPC follow‐ups were
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ACES: A new framework for the application of the 2018 periodontal status classification scheme to epidemiological survey data J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-22 Birte Holtfreter, Kathrin Kuhr, Katrin Borof, Maurizio S. Tonetti, Mariano Sanz, Kenneth Kornman, Søren Jepsen, Ghazal Aarabi, Henry Völzke, Thomas Kocher, Joachim Krois, Panos N. Papapanou
AimTo propose a framework for consistently applying the 2018 periodontal status classification scheme to epidemiological surveys (Application of the 2018 periodontal status Classification to Epidemiological Survey data, ACES).Proposed FrameworkWe specified data requirements and workflows for either completed or planned epidemiological surveys, utilizing commonly collected measures of periodontal status
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Response to Letter, “Autophagy Plays a Crucial Role in Ameloblast Differentiation” J. Dent. Res. (IF 7.6) Pub Date : 2024-02-21 C. Iwaya, J. Iwata
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Isolation, identification and osteogenic capability analysis of mesenchymal stem cells derived from different layers of human maxillary sinus membrane J. Clin. Periodontol. (IF 6.7) Pub Date : 2024-02-21 Huixin Lv, Jing Xu, Yihan Wang, Xiuyu Liu, Sheng Chen, Jingxia Chen, Jingjie Zhai, Yanmin Zhou
AimTo discover the populations of mesenchymal stem cells (MSCs) derived from different layers of human maxillary sinus membrane (hMSM) and evaluate their osteogenic capability.Materials and MethodshMSM was isolated into a monolayer using the combined method of physical separation and enzymatic digestion. The localization of MSCs in hMSM was performed by immunohistological staining and other techniques
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APCs in sinus floor augmentation Periodontol. 2000 (IF 18.6) Pub Date : 2024-02-16 Pascal Valentini, Elena Calciolari, Sebastien Monlezun, Aliye Akcalı, Nikos Donos, Marc Quirynen
After tooth loss in the posterior area of the maxilla, sinus floor elevation is often required to compensate the vertical bone loss due to sinus pneumatization. This narrative review reports on the potential benefits of autologous platelet concentrates (APCs) during this procedure. As for transcrestal approach, APCs have been used as “sole” substitute/graft. However, because of the low number of clinical
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A novel saliva-based miRNA profile to diagnose and predict oral cancer Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-18 Jaikrishna Balakittnen, Chameera Ekanayake Weeramange, Daniel F. Wallace, Pascal H. G. Duijf, Alexandre S. Cristino, Gunter Hartel, Roberto A. Barrero, Touraj Taheri, Liz Kenny, Sarju Vasani, Martin Batstone, Omar Breik, Chamindie Punyadeera
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Biological Properties of 3D-Printed Zirconia Implants with p-Cell Structures J. Dent. Res. (IF 7.6) Pub Date : 2024-02-20 W. Qin, MH. Shen, N. Gan, BH. Xing, J. Sun, Z. Zhao, T. Jiao
Research on 3-dimensional (3D) printed porous zirconia-based dental implants is still in its infancy. This study aimed to evaluate the biological responses of novel zirconia implants with p-cell structures fabricated by 3D printing. The solid zirconia samples exhibited comparable density, 3-point flexural strength, and accelerated aging properties compared to specimens prepared previously by conventional
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Evaluation of the effect of Er,Cr:YSGG laser application on peri‐implant crevicular fluid receptor activator of nuclear factor‐kappa B ligand and osteoprotegerin levels in the non‐surgical treatment of peri‐implantitis: A randomized clinical trial J. Periodontol. (IF 4.3) Pub Date : 2024-02-20 Nazli Zeynep Alpaslan, Dicle Altindal, Damla Akbal, Ahmet Cemil Talmac, Serap Keskin Tunc, Abdullah Seckin Ertugrul
BackgroundThis study aimed to investigate the effect of erbium, chromium doped:yttrium,scandium,gallium,garnet (Er,Cr:YSGG) laser application combined with non‐surgical mechanical debridement (MD) on clinical parameters and peri‐implant crevicular fluid receptor activator of nuclear factor‐kappa B ligand (RANKL) and osteoprotegerin (OPG) levels in the treatment of peri‐implantitis.MethodsA total of
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PRX1-positive mesenchymal stem cells drive molar morphogenesis Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-19 Xiaoqiao Xu, Xuyan Gong, Lei Zhang, Han Zhang, Yao Sun
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Genomic alterations in oral multiple primary cancers Int. J. Oral Sci. (IF 14.9) Pub Date : 2024-02-18 Xuan Zhou, Xinjia Cai, Fengyang Jing, Xuefen Li, Jianyun Zhang, Heyu Zhang, Tiejun Li
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Intelligently Quantifying the Entire Irregular Dental Structure J. Dent. Res. (IF 7.6) Pub Date : 2024-02-19 H. Liu, J. Duan, P. Zeng, M. Shi, J. Zeng, S. Chen, Z. Gong, Z. Chen, J. Qin, Z. Chen
Quantitative analysis of irregular anatomical structures is crucial in oral medicine, but clinicians often typically measure only several representative indicators within the structure as references. Deep learning semantic segmentation offers the potential for entire quantitative analysis. However, challenges persist, including segmentation difficulties due to unclear boundaries and acquiring measurement
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Radiographic evaluation of marginal bone levels around implants supporting splinted fixed bridges: A retrospective study on 412 implants Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-02-19 Mattia Manfredini, Pier Paolo Poli, Mario Beretta, Federico Rossi, Marta Rigoni, Valentina Veronesi, Carlo Maiorana
ObjectivesThe effect of the implant position within the prosthesis on bone remodeling is scarcely documented so far. Thus, the aim of the present study was to investigate whether central implants may suffer higher peri‐implant marginal bone levels (MBL) compared to laterals in case of fixed splinted bridges supported by ≥ three implants.Materials and MethodsPartially edentulous subjects rehabilitated
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Hard and soft tissue alterations using dual‐zone concept versus connective tissue graft at maxillary immediate implant placement: A 1‐year randomized clinical and volumetric trial Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-02-19 Ahmed Ibrahim Aboul Fettouh, Noha A. Ghallab, Nael Adel Mina, Mariam Samy Abdelmalak, Abdelrahman Ali Gamaleldin Abdelrahman, Ahmed Fouad Shalaby, Nesma Shemais
ObjectivesTo evaluate the esthetic outcome, as well as clinical, radiographic, and volumetric tissue alterations 1 year after immediate implant placement (IIP) with connective tissue grafting (CTG) versus dual‐zone concept (DZ) at sites with thin labial bone in the esthetic zone.Materials and MethodsThis randomized clinical trial included 30 patients treated with IIP simultaneous with either CTG or
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Clinical and radiographic outcomes of lateral sinus floor elevation with simultaneous hydrophilic implants placement: A retrospective study of 2–5 years Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-02-17 Yinjie Qian, Yuxin Zhao, Yifan Lu, Siqi Bao, Weijun Zhu, Qianming Chen, Misi Si
To investigate the clinical and radiographic outcomes of a chemically modified sandblasted large-grit acid-etched implant (hydrophilic) in lateral sinus floor elevation (LSFE), compared with a conventional one (hydrophobic).
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Survival time analysis of remaining teeth following replacement of unilateral free-end missing teeth: A comparison between fixed implant-supported prostheses and removable partial dentures Clin. Oral. Implants Res. (IF 4.3) Pub Date : 2024-02-16 Yoshitaka Tsujioka, Tomoaki Mameno, Suzuna Akema, Daisuke Hasegawa, Yoshie Okada, Eri Seto, Tomoya Gonda, Tsung-Chieh Yang, Masahiro Wada, Kazunori Ikebe
This retrospective study aimed to investigate the differences in tooth loss rate between fixed implant-supported prostheses (FISPs) and removable partial dentures (RPDs) in cases of unilateral free-end missing teeth.
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Effect of Periodontitis and Periodontal Therapy on Oral and Gut Microbiota J. Dent. Res. (IF 7.6) Pub Date : 2024-02-16 G. Baima, I. Ferrocino, V. Del Lupo, E. Colonna, V. Thumbigere-Math, G.P. Caviglia, I. Franciosa, G.M. Mariani, M. Romandini, D.G. Ribaldone, F. Romano, M. Aimetti
Mounting evidence indicates that periodontitis-related oral bacteria may contribute to gut microbial dysbiosis. This clinical study aimed to explore the oral–gut microbial signatures associated with periodontitis and to longitudinally evaluate the effect of periodontal treatment on the oral and gut microbial composition. Stool and saliva samples from generalized stage III/IV periodontitis patients