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Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-17 Amit Kumar Chakraborty, Rajnikant Dilip Raut, Kisa Iqbal, Chumki Choudhury, Thabet Alhousami, Sami Chogle, Alexa S. Acosta, Lana Fagman, Kelly Deabold, Marilia Takada, Bikash Sahay, Vikas Kumar, Manish V. Bais
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Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-17 Feilong Ren, Shize Zheng, Huanyu Luo, Xiaoyi Yu, Xianjing Li, Shaoyi Song, Wenhuan Bu, Hongchen Sun
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Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via NF-κB activation Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-17 Shengjie Cui, Yanning Guo, Yu Fu, Ting Zhang, Jieni Zhang, Yehua Gan, Yanheng Zhou, Yan Gu, Eileen Gentleman, Yan Liu, Xuedong Wang
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Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-17 Yanyi Liu, Yuhao Peng, Lanhui Chen, Yangfan Xiang, Ximu Zhang, Jinlin Song
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NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-17 Xiping Wang, Li Wang, Linxi Zhou, Lu Chen, Jiayi Shi, Jing Ge, Sha Tian, Zihan Yang, Yuqiong Zhou, Qihao Yu, Jiacheng Jin, Chen Ding, Yihuai Pan, Duohong Zou
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Dimethyl fumarate modulates M1/M2 macrophage polarization to ameliorate periodontal destruction by increasing TUFM-mediated mitophagy Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-17 Liang Chen, Pengxiao Hu, Xinhua Hong, Bin Li, Yifan Ping, ShuoMin Chen, Tianle Jiang, Haofu Jiang, Yixin Mao, Yang Chen, Zhongchen Song, Zhou Ye, Xiaoyu Sun, Shufan Zhao, Shengbin Huang
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Programmed death-ligand 1 regulates ameloblastoma growth and recurrence Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-16 Linzhou Zhang, Hao Lin, Jiajie Liang, Xuanhao Liu, Chenxi Zhang, Qiwen Man, Ruifang Li, Yi Zhao, Bing Liu
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Soft-tissue volume augmentation during early, delayed, and late dental implant therapy: A systematic review and meta-analysis on professionally determined esthetics and self-reported patient satisfaction on esthetics. Periodontol. 2000 (IF 17.5) Pub Date : 2025-04-16 Ausra Ramanauskaite,Sofya Sadilina,Frank Schwarz,Emilio A Cafferata,Franz J Strauss,Daniel S Thoma
The objective of the study was to assess the effect of soft-tissue volume augmentation during early, delayed, and late dental implant therapy in terms of professionally determined esthetics and self-reported patient satisfaction on esthetics. For this, a comprehensive electronic literature search was performed to identify randomized clinical trials (RCTs) and controlled clinical trials (CCTs) reporting
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Patient‐Centred Preferences for Autonomy and Information‐Seeking Among Periodontal Patients in Dental Decision Making J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-16 Ji‐Young Jung, Kyung‐A Ko, Franz J. Strauss, Jae‐Hong Lee, Jun‐Hewk Kim, Jung‐Seok Lee
Background and AimManaging periodontal disease often involves complex decisions involving multiple treatment options, and patient autonomy significantly influences this decision‐making process. This study aimed to characterise the autonomy and information‐seeking preferences among patients diagnosed with stage III/IV periodontitis, and to identify the factors influencing these preferences.Materials
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Macrophage Depletion Reduces Bone Loss and Alters Inflammatory Responses: A Mouse Peri‐Implantitis Model J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-16 Ofir Ginesin, Benjamin R. Coyac, Ofri Doppelt‐Flikshtain, Yaniv Mayer, Eran Gabay, Tal Berg, Yotam Bar‐On, Hadar Zigdon‐Giladi
AimTo evaluate the impact of macrophage depletion on bone loss and inflammatory responses in a mouse model of peri‐implantitis, assessing macrophage depletion potential as a therapeutic strategy.Materials and MethodsUsing 6‐week‐old male C57BL/6 mice, peri‐implantitis was induced by placing a silk ligature around osteointegrated dental implants. Mice were divided into three groups: Healthy control
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Early Buccal Bone Resorption in Areas With or Without Keratinized Tissue and Different Mucosal Thickness at Implants in Healed Sites: An Experimental Animal Study J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-16 Antonio Liñares, Hong Jin Tan, Fernando Muñoz, Dragana Rakasevic, Yago Leira, Juan Blanco
AimTo evaluate early buccal bone resorption (BBR) in areas with or without buccal keratinized tissue (KT), and different mucosal thickness (MT) following implant placement at healed sites.Materials and MethodsIn 9 beagle dogs, three months following the hemimaxilla third and fourth premolars extraction, full‐thickness flaps were elevated and two tissue‐level implants were inserted. Before suturing
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A New Method for Volumetric Analysis of Soft‐Tissue Changes Using Three‐Dimensional Imaging in Patients With Periodontitis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-16 Aleksandar Pupovac, Davor Kuiš, Ivana Mišković, Stjepan Špalj, Alexei Zhurov, Jelena Prpić
AimsTo quantify changes in soft‐tissue volume induced by non‐surgical periodontal therapy (NSPT) in patients with periodontitis and correlate them with clinical parameters and smoking. A new digital approach is investigated because standard periodontal clinical assessment methods are unable to accurately capture volumetric changes.Materials and MethodsThirty‐nine subjects with periodontitis aged 27–70
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Peri‐implant inflammation increases the risk of osteonecrosis in mice treated with bisphosphonate J. Periodontol. (IF 4.2) Pub Date : 2025-04-15 Ana Bujila, Davi N. A. Silva, Sepehr Monajemzadeh, Taciane M. da Silveira, Naseim Elzakra, Maísa Casarin, Kimberly Flores, Clara Magyar, Julie Marchesan, Reuben Kim, Sotirios Tetradis, Flavia Q. Pirih
BackgroundBisphosphonates (BPs) are effective in managing bone diseases due to their anti‐resorptive properties but are linked to medication‐related osteonecrosis of the jaw (MRONJ), particularly concerning dental implants. This study explored the combined impact of ligature‐induced peri‐implant inflammation and zoledronic acid (ZA), a BP, using a murine model.MethodsTwenty‐four mice underwent bilateral
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Accuracy of Digital Impression Methods for Capturing the Peri‐Implant Emergence Profile: A Systematic Review Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-04-12 Krisztina Mikulás, Xinyi Qian, Péter Tajti, Gergely Agócs, German O. Gallucci, Ignacio Pedrinaci, Péter Hermann
BackgroundAccurately replicating the emergence profile (EP) of conditioned soft tissue is pivotal for the success of implant‐supported restorations. In the field of digital technology, various methods have emerged to capture EP. This review aims to critically assess current digital methodologies for capturing peri‐implant EP.Material and MethodsProspective interventional or observational clinical studies
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Efficacy of Injectable Bone Fillers for Alveolar Ridge Preservation: A Histomorphometrical Analysis J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-11 Frank Schwarz, Ausra Ramanauskaite, Karina Obreja, Jonas Lorenz, Robert Sader, Puria Parvini
AimTo assess the efficacy of injectable bone fillers for alveolar ridge preservation (ARP).Materials and MethodsThe mandibular premolars (P2, P3, P4) were bilaterally assigned to ARP in a total of n = 9 beagle dogs. Each P was decapitated and hemisected under preservation of the mesial (i.e., devitalization and filling with calcium hydroxide) and removal of the distal root. The resulting 6 extraction
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Knowledge and use of digital technologies in periodontal practices in the United States: A survey study J. Periodontol. (IF 4.2) Pub Date : 2025-04-10 Mina Youssef, Dimitris N. Tatakis, Catherine Demko, Gian Pietro Schincaglia
BackgroundThe widespread adoption of digital technologies in dentistry has transformed workflows and practices. However, limited, if any, information is available on the extent of digital workflow integration in periodontics. This study aims to evaluate literacy, utilization, and knowledge of digital technologies, specifically implant navigation systems, among American board‐certified periodontists
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Influence of soft tissue thickness, blade type, and guide design, on computer‐assisted esthetic crown lengthening J. Periodontol. (IF 4.2) Pub Date : 2025-04-10 Panagiotis Ntovas, Lorenzo Tavelli, Basir A. Barmak, Ronald E. Jung, Maria‐Elisa Galarraga‐Vinueza
BackgroundThe aim of this study was to evaluate the effect of surgical guide design and type of blade, in relation to soft tissue thickness, on the accuracy of computer‐assisted crown lengthening.MethodsA set of fully dentate anatomic maxilla models was implemented, using 2 types of soft‐tissue masks with a mean thickness of 1.5 and 3.5 mm, respectively, to simulate a clinical scenario of altered passive
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AI‐Driven Detection and Measurement of Keratinized Gingiva in Dental Photographs: Validation Using Reference Retainers J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-08 Ya‐Chi Chen, Ling Chen, Yu‐Lin Lai, Wei‐Ting Chang, Shyh‐Yuan Lee
AimTo evaluate a deep learning (DL) model for detecting keratinized gingiva (KG) in dental photographs and validate its clinical applicability using reference retainers for calibration.Materials and MethodsA total of 576 sextant photographs were selected from 32 subjects, each with three sets of photographs: iodine‐stained, unstained and line‐marked retainers. Relative keratinized gingiva width (rKGW)
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Genetic Biomarkers for Periodontal Diseases: A Systematic Review J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-08 H. Dommisch, D. Hoedke, E. M.‐C. Lu, A. Schäfer, G. Richter, J. Kang, L. Nibali
AimsTo identify genetic biomarkers that may be used in the diagnosis, prevention or management of different forms of periodontal disease.Materials and MethodsFollowing protocol registration and PICOTS (patient, intervention, comparison, outcome, time, studies) questions, a systematic search of the literature was conducted (PudMed, Ovid), resulting in 1592 papers screened by two reviewers. Diagnostic
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Clinical Performance of Immediately Placed and Restored Implants With a Novel Design in the Esthetic Zone. A 3‐Year Follow‐Up of Prospective Case Series Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-04-07 Frank Schwarz, Georgina Trimpou, Alexa Montada, Karina Obreja, Puria Parvini, Amira Begić
AimTo assess the medium‐term implant success and survival rates of immediately placed and restored implants with a novel design in the esthetic zone.Materials and MethodsA total of n = 20 patients had received immediately placed tapered, two‐part implants with a progressive thread design (PL) (n = 20) and an immediate “non full‐functional” loading (patient‐specific abutments) for single tooth replacements
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Dental Implant Therapy in Patients With Autoimmune Diseases: A Scoping Review Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-04-05 Emil Hyldahl, Henning Schliephake, Simon Storgård Jensen
ObjectivesThe aim of this scoping review is to determine the effects of autoimmune diseases (ADs) and the agents used for treatment on dental implant survival and biologic outcomes.Material and MethodsAn electronic database search was performed in MEDLINE (PubMed), The Cochrane Library, and Embase on 29‐04‐2024. Clinical studies in English on implant therapy in patients with ADs were potentially eligible
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Genomic and Transcriptomic Adaptation to Chlorhexidine in Streptococcus spp. J. Dent. Res. (IF 5.7) Pub Date : 2025-04-04 B. Daller, D.L. Auer, W. Buchalla, S. Bartsch, A. Gessner, N.S. Jakubovics, A. Al-Ahmad, A. Hiergeist, F. Cieplik
Antiseptics such as chlorhexidine digluconate (CHX) are widely used in clinical dental practice, but their potential risks, particularly regarding antimicrobial resistance (AMR), are not yet known. This study explores the genomic and transcriptomic mechanisms of CHX adaptation in 3 clinical isolates of Streptococcus spp. and their adapted counterparts. The genomic analysis revealed mutations in genes
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Evaluation of Image Clarity in Smartglass‐Supported Dynamic Computer‐Assisted Implant Surgery: A Clinical Pilot Trial Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-04-04 Poyuan Hsueh, Yoko Yamaguchi, Yiwen Wang, Takao Kasahara, Daisuke Higuchi, Yasutomo Yajima
ObjectivesThis study evaluated the image quality of smartglass‐supported Dynamic Computer‐Assisted Implant Surgery (dCAIS) by testing discernibility with a Landolt ring chart reproduced with smartglasses and on the dCAIS monitor.Materials and Methods15 participants’ discernibility was measured under four conditions using Landolt rings. Each condition measured 13 visual acuity levels, with each level
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Metformin reverses periodontal destruction caused by experimental periodontitis by inhibiting interleukin‐1β activity J. Periodontol. (IF 4.2) Pub Date : 2025-04-04 Zhao Wang, Ju Han Song, Jung‐Woo Kim, Seung‐Hee Kwon, Xianyu Piao, Sin‐Hye Oh, Suk‐Gyun Park, Sun‐Hun Kim, Je‐Hwang Ryu, Ok‐Su Kim, Jeong‐Tae Koh
BackgroundPeriodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first‐line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients. However, its potential for repairing periodontal tissue remains unclear. Therefore, this study aimed to
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Comparison of four bone substitute types in sinus augmentation with perforated Schneiderian membrane: An experimental study J. Periodontol. (IF 4.2) Pub Date : 2025-04-04 Jung‐Tae Lee, Seok Hyun Lee, Baek Sun Choi, Sungtae Kim
BackgroundCollagenated bovine bone mineral (CBBM) is used for maxillary sinus elevation‐based augmentation. We compared collagen degradation in cross‐linked (CL) CBBM and non‐cross‐linked (NCL) CBBM (in vitro) and preclinical results in CBBM‐CL, CBBM‐NCL, deproteinized bovine bone mineral (DBBM), and DBBM with fibrin sealant grafts (in vivo) after repair of perforated Schneiderian membrane (SM).Me
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Expert consensus on orthodontic treatment of patients with periodontal disease Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-03 Wenjie Zhong, Chenchen Zhou, Yuanyuan Yin, Ge Feng, Zhihe Zhao, Yaping Pan, Yuxing Bai, Zuolin Jin, Yan Xu, Bing Fang, Yi Liu, Hong He, Faming Chen, Weiran Li, Shaohua Ge, Ang Li, Yi Ding, Lili Chen, Fuhua Yan, Jinlin Song
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A Real‐World Evidence Study Evaluating Oral‐Health‐Related Quality of Life Following the Use of Anti‐Sensitivity Toothpaste for Self‐Reported Dentine Hypersensitivity Management J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-04-03 Roberta Grimaldi, Sarah R. Baker, Parth Shah, Edwin Sanchez, Gilbert Shanga, Paola R. Gomez‐Pereira, Charlie R. Parkinson
AimsTo evaluate the impact of an anti‐sensitivity toothpaste on the oral‐health‐related quality of life (OHrQoL) in a real‐world (RW) setting.Materials and MethodsThis was a decentralised, prospective, 24‐week, open‐label study in participants with self‐reported dentine hypersensitivity (DH). A total of 655 enrolled participants used a 5% potassium nitrate toothpaste per label instructions and completed
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Exploring the mechanical and biological interplay in the periodontal ligament Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-02 Xinyu Wen, Fang Pei, Ying Jin, Zhihe Zhao
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Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnfα transcription Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-01 Zhichun Jin, Hao Xu, Weiye Zhao, Kejia Zhang, Shengnan Wu, Chuanjun Shu, Linlin Zhu, Yan Wang, Lin Wang, Hanwen Zhang, Bin Yan
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Expert consensus on early orthodontic treatment of class III malocclusion Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-01 Xin Zhou, Si Chen, Chenchen Zhou, Zuolin Jin, Hong He, Yuxing Bai, Weiran Li, Jun Wang, Min Hu, Yang Cao, Yuehua Liu, Bin Yan, Jiejun Shi, Jie Guo, Zhihua Li, Wensheng Ma, Yi Liu, Huang Li, Yanqin Lu, Liling Ren, Rui Zou, Linyu Xu, Jiangtian Hu, Xiuping Wu, Shuxia Cui, Lulu Xu, Xudong Wang, Songsong Zhu, Li Hu, Qingming Tang, Jinlin Song, Bing Fang, Lili Chen
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Expert consensus on imaging diagnosis and analysis of early correction of childhood malocclusion Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-04-01 Zitong Lin, Chenchen Zhou, Ziyang Hu, Zuyan Zhang, Yong Cheng, Bing Fang, Hong He, Hu Wang, Gang Li, Jun Guo, Weihua Guo, Xiaobing Li, Guangning Zheng, Zhimin Li, Donglin Zeng, Yan Liu, Yuehua Liu, Min Hu, Lunguo Xia, Jihong Zhao, Yaling Song, Huang Li, Jun Ji, Jinlin Song, Lili Chen, Tiemei Wang
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Peri‐implantitis reconstructive treatment implementing a titanium brush: 5‐year extension results from a randomized clinical trial J. Periodontol. (IF 4.2) Pub Date : 2025-03-31 Beatriz de Tapia, Tiago Ribeiro‐Amaral, Carolina Mor, José Nart, Cristina Valles
BackgroundPeri‐implantitis has become an important health issue in implant dentistry in the past years. Despite the magnitude of this problem and the potential grave consequences, the predictability and long‐term stability of its treatment is still a matter of controversy. The aim of this study was to assess clinical and radiographic results 5 years after the peri‐implantitis reconstructive treatment
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Prior chronic periodontitis is associated with chronic rhinosinusitis: A population‐based case‐control study J. Periodontol. (IF 4.2) Pub Date : 2025-03-31 Tzong‐Hann Yang, Yen‐Fu Cheng, Herng‐Ching Lin, Chin‐Shyan Chen
BackgroundChronic rhinosinusitis (CRS) and chronic periodontitis (CP) are prevalent inflammatory conditions with significant impacts on health. Previous research has suggested a potential link between these diseases, primarily through odontogenic sources, but comprehensive population‐based studies are scarce. This study aimed to explore the association of CRS with prior CP.MethodsWe performed a case‐control
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Immediate postoperative anesthesia with either lidocaine or bupivacaine: A short‐term clinical response J. Periodontol. (IF 4.2) Pub Date : 2025-03-31 Jessica D. Koster, David E. Deas, Archontia Palaiologou, David J. Lasho, Anibal Diogenes
BackgroundThe purpose of this randomized, three‐armed clinical trial is to determine if a postoperative injection of 0.5% bupivacaine is more effective than 2% lidocaine in controlling pain after periodontal flap surgery.MethodsSeventy‐six patients planned for similar periodontal surgeries were included. Prior to surgery, patients were randomized to receive one cartridge (1.7 mL) of either 2% lidocaine
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Taurine levels in periodontitis: A pilot study J. Periodontol. (IF 4.2) Pub Date : 2025-03-31 Mehmet Fatih Dönmez, Nur Balci, Aslı Ergene Sunkar, Hilal Toygar, Alpdoğan Kantarcı
BackgroundPeriodontitis is a chronic inflammatory condition that affects the supporting structures of the teeth. It is closely associated with oxidative stress and inflammation. Taurine, a semi‐essential amino acid recognized for its antioxidant and anti‐inflammatory properties, has not been extensively investigated in the context of periodontitis. This pilot study sought to evaluate the levels of
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Cover Image J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-30 Istvan A. Urban, Matteo Serroni, Debora R. Dias, Zoltán Baráth, Andras Forster, Tiago G. Araújo, Muhammad H. A. Saleh, Alessandro Cucchi, Andrea Ravidà
The cover image is based on the article Impact of Collagen Membrane in Vertical Ridge Augmentation Using Ti‐Reinforced PTFE Mesh: A Randomised Controlled Trial by Istvan A. Urban et al., https://doi.org/10.1111/jcpe.14129. image
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Manufacturing and Application Precision Changes in Three‐Dimensional Printed Surgical Guides for Dental Implants: An In Vitro Study Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-03-29 Mengxi Yang, Ruikun Li, Xueyuan Li, Shibo Liu, Songhang Li
ObjectivesTo assess the reproduction accuracy of a surgical guide during both the manufacturing phase (from designed files to manufactured surgical guides) and the application phase (from manufactured surgical guides to post‐plasma sterilization) across four three‐dimensional (3D) printing technologies.Materials and MethodsTwenty‐four surgical guides were designed and categorized into four groups (six
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Force Feedback Implant Robot With Osseodensification Drilling for Transcrestal Sinus Floor Elevation: A Retrospective Case Series Study Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-03-29 YaXin Bai, Yuan Chen, MinXue Yang, YuanDing Huang, Peng Xu, Tao Chen
ObjectivesThis study evaluated the effectiveness of force‐feedback–based autonomous dental implant robotic systems combined with osseodensification (OD) for transcrestal sinus floor elevation (TSFE), to understand patterns of force‐feedback curves, visualize the TSFE process through mechanical vision, and offer new perspectives on surgical strategies.Materials and MethodsThe included patients required
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Impact of Multimedia Information on Patients' Knowledge, Anxiety and Decision‐Making Regarding Computer‐Assisted and Freehand Dental Implant Surgery: A Randomised Clinical Trial Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-03-29 Veerawit Lukkanasomboon, Nikos Mattheos, Sappasith Panya, Pagaporn Pantuwadee Pisarnturakit, Atiphan Pimkhaokham, Keskanya Subbalekha
ObjectiveThis randomised clinical trial aimed to compare the effects of multimedia information and verbal explanations on patients' knowledge and anxiety as primary outcomes and decision‐making as a secondary outcome.Materials and MethodsOne hundred patients needing dental replacement were randomly assigned (1:1) to either a multimedia group (n = 50) or a verbal group (n = 50). They completed self‐administered
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Author Correction: LIMP-2 enhances cancer stem-like cell properties by promoting autophagy-induced GSK3β degradation in head and neck squamous cell carcinoma Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-03-28 Yuantong Liu, Shujin Li, Shuo Wang, Qichao Yang, Zhizhong Wu, Mengjie Zhang, Lei Chen, Zhijun Sun
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Abnormal collagen deposition mediated by cartilage oligomeric matrix protein in the pathogenesis of oral submucous fibrosis Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-03-27 Yafei Xiong, Xuechun Li, Bincan Sun, Jie Zhang, Xiaoshan Wu, Feng Guo
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Advantages of horizontal centrifugation of platelet‐rich fibrin in regenerative medicine and dentistry Periodontol. 2000 (IF 17.5) Pub Date : 2025-03-27 Nima Farshidfar, Karol Alí Apaza Alccayhuaman, Nathan E. Estrin, Paras Ahmad, Anton Sculean, Yufeng Zhang, Richard J. Miron
The aim of this comprehensive review was to evaluate comparative studies on horizontal and fixed‐angle centrifugation methods for preparing platelet‐rich fibrin (PRF). Furthermore, additional studies utilizing horizontal PRF (H‐PRF) were systematically investigated. This overview review article offers deeper insights into the advantages of H‐PRF when compared to fixed‐angle methods across a wide range
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DNMTi@ZIF-8 Enhances Biomimetic Pulp Regeneration via Epigenetic Regulation J. Dent. Res. (IF 5.7) Pub Date : 2025-03-27 Z. Li, M. Wan, D. Cui, Q. Tian, Y. Li, S. Yu, L. Zheng, L. Ye
Regenerating the functional dentin–pulp complex remains a significant challenge in endodontics. Conventional regenerative endodontic therapies often result in the formation of non–pulp-like tissue due to the uncontrolled induction of stem cells and cytokines. Mimicking developmental processes to promote regeneration represents a promising yet challenging approach in regenerative medicine. This study
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Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells Int. J. Oral Sci. (IF 10.8) Pub Date : 2025-03-26 Meijun Hu, Zhipeng Fan
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Mechanisms Tackling Salivary Gland Diseases with Extracellular Vesicle Therapies J. Dent. Res. (IF 5.7) Pub Date : 2025-03-26 P. Sawutdeechaikul, S. Hwang, J. Klangprapan, T.V. Phan, C. Buu Lam, Y.-J. Yoon, S. Seo, S. Hong, J.-Y. Lim, J.N. Ferreira
Extracellular vesicles (EVs) are lipid-enclosed particles released from cells, containing lipids, DNA, RNA, metabolites, and cytosolic and cell surface proteins. EVs support intercellular communication and orchestrate organogenesis by transferring bioactive molecules in between cells. Mesenchymal stem cells are known to produce EVs, which exhibit immunomodulatory and regenerative capabilities in many
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Platelet‐rich plasma (PRP) versus injectable platelet‐rich fibrin (i‐PRF): A systematic review across all fields of medicine Periodontol. 2000 (IF 17.5) Pub Date : 2025-03-25 Nima Farshidfar, Mohammad Amin Amiri, Nathan E. Estrin, Paras Ahmad, Anton Sculean, Yufeng Zhang, Richard J. Miron
This systematic review aimed to evaluate all available evidence across all fields of medicine regarding the comparative effectiveness of platelet‐rich plasma (PRP) versus injectable platelet‐rich fibrin (i‐PRF). A comprehensive search was conducted in PubMed, Scopus, and Web of Science up to September 30, 2024. Following a thorough screening process, studies were divided into in vitro, in vivo, and
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Dental‐implant inflamed surface area: A quantification and simulation study J. Periodontol. (IF 4.2) Pub Date : 2025-03-25 Yumeng Yan, Praveen Sharma, Jeanie Suvan, Carlota Blanco, Antonio Linares, Yago Leira, Juan Blanco, Francesco D'Aiuto
BackgroundPeri‐implantitis is an oral inflammatory disease with increased incidence across the population as linked to the wide use of dental implants to replace missing teeth. While the recent World Workshop Classifications provided a framework for clinicians to diagnose and assess the severity of peri‐implantitis, an objective assessment of the mucosal inflammatory burden around the dental implant
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Treatment of peri‐implantitis with diode laser or mucosal flap surgery: A clinical randomized controlled trial J. Periodontol. (IF 4.2) Pub Date : 2025-03-25 Sebastian Malmqvist, Talat Qadri, Ronaldo Lira‐Junior, Elisabeth A. Boström, Anders Gustafsson, Georgios N. Belibasakis, Angelika Silbereisen, Gunnar Johannsen, Annsofi Johannsen
BackgroundPeri‐implantitis poses a major challenge as contemporary nonsurgical treatments show dissatisfactory results and mucosal flap surgery is often needed. Diode lasers can remove granulation tissue and submucosal bacteria, and if it achieves similar clinical results, then it could be used as a less invasive first approach. The aim was to compare the healing of peri‐implantitis lesions 6 months
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Systemic Azithromycin as an Adjunct to Non‐Surgical Subgingival Instrumentation in the Treatment of Stage III/IV, Grade C Periodontitis: 12‐Month Clinical, Microbiological and Cytokine Results of a Randomised Controlled Trial J. Clin. Periodontol. (IF 5.8) Pub Date : 2025-03-24 Srinivas Sulugodu Ramachandra, Valerie Woodford, Pingping Han, Ryan S. B. Lee, Sašo Ivanovski
AimTo evaluate the clinical, microbial and cytokine changes following the use of oral azithromycin as an adjunct to non‐surgical subgingival instrumentation (NSI) in stage III/IV, grade C periodontitis through a triple‐blind, parallel‐armed, randomised controlled trial.Material and MethodsA total of 52 patients with stage III/IV grade C periodontitis were randomly allocated to two groups receiving
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Corrigendum to MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery J. Dent. Res. (IF 5.7) Pub Date : 2025-03-24
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Particulate Versus Cross‐Linked Collagenated Bone Substitutes for Guided Bone Regeneration: A Randomized Controlled Trial Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-03-24 Ji‐Young Jung, Seung‐Hyun Park, Kwan‐Jung Kim, Kyung‐A Ko, Dong‐Woon Lee, Jung‐Seok Lee
AimTo compare the dimensional outcomes of horizontal augmentation with the retentive‐flap technique using particulate and cross‐linked collagenated bone substitutes.Materials and MethodsThis two‐centre, two‐arm randomized clinical trial investigated 69 subjects: 34 in the particulate group and 35 in the collagenated group. Patients were randomly assigned to receive single implant placement with simultaneous
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Premature Bone Resorption in Vertical Ridge Augmentation: A Systematic Review and Network Meta‐Analysis of Randomised Clinical Trials Clin. Oral. Implants Res. (IF 4.8) Pub Date : 2025-03-23 Faisal Faihan Alotaibi, Jacopo Buti, Isabella Rocchietta, Nor Shafina Mohamed Nazari, Rawan Almujaydil, Francesco D'Aiuto
ObjectivesTo systematically appraise the evidence on premature ridge resorption following various vertical ridge augmentation (VRA) techniques in healthy adult patients undergoing staged VRA procedures. The study aimed to identify VRA techniques resulting in the least premature bone resorption and to rank them using Bayesian Network Meta‐Analysis (NMA).Material and MethodsSearches were conducted in
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Fighting the Antimicrobial Resistance Global Emergency: The Lifesaving Role of Dentistry J. Dent. Res. (IF 5.7) Pub Date : 2025-03-20 W. Thompson, F. Cieplik, L. Teoh, N. Jakubovics, H. Benzian